GB818519A - Protein complexes - Google Patents
Protein complexesInfo
- Publication number
- GB818519A GB818519A GB26481/55A GB2648155A GB818519A GB 818519 A GB818519 A GB 818519A GB 26481/55 A GB26481/55 A GB 26481/55A GB 2648155 A GB2648155 A GB 2648155A GB 818519 A GB818519 A GB 818519A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atoms
- alcohol
- acids
- fluorinated
- perfluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Proteinaceous materials are protected from heat or chemical denaturation by adding a completely or partially fluorinated aliphatic acid, amine, alcohol or alcohol derivative, having at least two carbon atoms or a salt thereof, which provides an anion or cation with a non-polar group when in aqueous solution, to a solution of proteinaceous material to form a fluoro compound-protein complex, the resulting solution having a pH such that the fluorinated compound and the proteinaceous material carry like charges, i.e. above the isoelectric point when a fluorinated acid or alcohol is used, and below the isoelectric point when a fluorinated amine is used, and being capable of being heated to an elevated temperature, e.g. to sterilize the protein, or to which a potentially denaturing substance may be added without denaturation of the protein. The proteinaceous material, e.g. ovalbumin, gelatin, human serum albumin, fibrinogen, bovine gamma globulin, beta lactoglobulin, viruses, antitoxins or enzymes such as urease, may be extracted from the complex by dilution, dialysis or ion exchange procedure. Specified fluoro-compounds are perfluoro-butyric, -caproic, -caprylic, -capric, and -lauric acids and the corresponding acids in which the omega fluorine atom is replaced by hydrogen, together with omega hydro perfluoro-pelorganic, -undecoic, and -tridecoic acids and salts thereof; alpha-dihydroperfluoro aliphatic acids having four to twelve carbon atoms and alphadihydro perfluoro aliphatic amines having from two to twelve carbon atoms and their salts, e.g. hydrochloride, hydrobromide, sulphate, and phosphate. The term "alcohol derivative" is defined as a partially fluorinated aliphatic alcohol of formul (i) ROSO3H, (ii) ROSO2X, and (iii) RSO3H and their salts, where X is a metal or ammonium, R is a fluoroalkyl radical containing at least two carbon atoms, e.g. fluoro-butyric, -caproic, -caprylic, -capric or -lauric radical. Specification 818,520 is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US818519XA | 1954-09-15 | 1954-09-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB818519A true GB818519A (en) | 1959-08-19 |
Family
ID=22166806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB26481/55A Expired GB818519A (en) | 1954-09-15 | 1955-09-15 | Protein complexes |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB818519A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3190869A (en) * | 1959-02-17 | 1965-06-22 | Hoechst Ag | Process for n-trifluoracetylating amino acids and peptides |
-
1955
- 1955-09-15 GB GB26481/55A patent/GB818519A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3190869A (en) * | 1959-02-17 | 1965-06-22 | Hoechst Ag | Process for n-trifluoracetylating amino acids and peptides |
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