GB807115A - New nicotinic acid esters and process of making the same - Google Patents
New nicotinic acid esters and process of making the sameInfo
- Publication number
- GB807115A GB807115A GB32994/56A GB3299456A GB807115A GB 807115 A GB807115 A GB 807115A GB 32994/56 A GB32994/56 A GB 32994/56A GB 3299456 A GB3299456 A GB 3299456A GB 807115 A GB807115 A GB 807115A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nicotinic acid
- pyridine
- making
- reacting
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises nicotinoyl-7-hydroxyethyl theophylline and dinicotinoylmorphine, and their preparation by reacting the appropriate hydroxy compound with nicotinic acid in the presence of a dehydrating agent, for example phosphorus oxychloride, or with a functional derivative of nicotinic acid, for example nicotinic acid anhydride or nicotinic acid halide (in the form of the hydrohalide salt). In examples, nicotinoyl 7-hydroxy-theophylline is prepared by reacting 7-hydroxytheophylline with (1) nicotinic acid anhydride and (2) nicotinic acid chloride-hydrochloride in pyridine; dinicotinoylmorphine is obtained by reacting anhydrous morphine hydrochloride with (3) nicotinic acid anhydride, (4) nicotinic acid chloride-hydrochloride in pyridine and (5) nicotinic acid in pyridine in the presence of phosphorus oxychloride.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT807115X | 1955-12-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB807115A true GB807115A (en) | 1959-01-07 |
Family
ID=3681253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB32994/56A Expired GB807115A (en) | 1955-12-14 | 1956-10-29 | New nicotinic acid esters and process of making the same |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB807115A (en) |
-
1956
- 1956-10-29 GB GB32994/56A patent/GB807115A/en not_active Expired
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