GB803062A - Improved method for preparation of 3, 4-dimethyl-5-sulfanilamido-isoxazole - Google Patents

Improved method for preparation of 3, 4-dimethyl-5-sulfanilamido-isoxazole

Info

Publication number
GB803062A
GB803062A GB3602/57A GB360257A GB803062A GB 803062 A GB803062 A GB 803062A GB 3602/57 A GB3602/57 A GB 3602/57A GB 360257 A GB360257 A GB 360257A GB 803062 A GB803062 A GB 803062A
Authority
GB
United Kingdom
Prior art keywords
dimethyl
isoxazole
chlorosulphonylphenyl
water
amidophosphoryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3602/57A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ISITUTO DE ANGELI SpA
Original Assignee
ISITUTO DE ANGELI SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ISITUTO DE ANGELI SpA filed Critical ISITUTO DE ANGELI SpA
Publication of GB803062A publication Critical patent/GB803062A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C07D261/16—Benzene-sulfonamido isoxazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)

Abstract

3 : 4 - Dimethyl - 5 - sulphanilamido - isoxazole (p - chlorosulphonylphenyl) - amidophosphoryldichloride, ClSO2.C6H4.NH.POCl2, with 3 : 4-dimethyl - 5 - amino - isoxazole, in the presence of water and hydrolysing the product by heating in an acid medium. The condensation reaction is preferably carried out in the presence of a tertiary organic base and in the presence of a water-miscible solvent. In examples: (1) 3 : 4 - dimethyl - 5 - aminoisoxazole, dissolved in acetone containing a minor amount of water, is treated with moist (p-chlorosulphonylphenyl) amidophosphoryl dichloride and the reaction product is heated with hydrochloric acid to give 3 : 4 - dimethyl - 5 - sulphanilamido - isoxazole; and (2) the process of (1) is carried out using pyridine as a condensing agent in the first stage. Starting materials. p-(Chlorosulphonylphenyl)-amidophosphoryl dichloride is made by the action of phosphorus pentachloride on sulphanilic acid.
GB3602/57A 1956-12-22 1957-02-01 Improved method for preparation of 3, 4-dimethyl-5-sulfanilamido-isoxazole Expired GB803062A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT803062X 1956-12-22

Publications (1)

Publication Number Publication Date
GB803062A true GB803062A (en) 1958-10-15

Family

ID=11316915

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3602/57A Expired GB803062A (en) 1956-12-22 1957-02-01 Improved method for preparation of 3, 4-dimethyl-5-sulfanilamido-isoxazole

Country Status (1)

Country Link
GB (1) GB803062A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5226952A (en) * 1991-05-17 1993-07-13 Pechiney Electrometallurgie Nitride process for refining calcium

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5226952A (en) * 1991-05-17 1993-07-13 Pechiney Electrometallurgie Nitride process for refining calcium

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