GB801536A - Antibiotically active derivatives of spiramycins - Google Patents
Antibiotically active derivatives of spiramycinsInfo
- Publication number
- GB801536A GB801536A GB37877/56A GB3787756A GB801536A GB 801536 A GB801536 A GB 801536A GB 37877/56 A GB37877/56 A GB 37877/56A GB 3787756 A GB3787756 A GB 3787756A GB 801536 A GB801536 A GB 801536A
- Authority
- GB
- United Kingdom
- Prior art keywords
- spiramycins
- neospiramycins
- per
- neospiramycin
- spiramycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
Neospiramycins having in general greater antibacterial properties than the spiramycins are prepared by adjusting aqueous, alcoholic or aqueous alcoholic solutions of the corresponding spiramycins (spiramycin, spiramycins I, II and III or their mixtures) to a pH of 3 to 5 with an acid such as sulphuric acid and maintaining said solutions at a temperature between 20 DEG and 50 DEG C. until their antibacterial activity remains constant when tested against B. subtilis ATCC 6633. The reaction solution is made alkaline, e.g. to pH 10, with sodium hydroxide, extracted with a water-immiscible solvent and the neospiramycin isolated by evaporating the solvent at below 50 DEG C. It is further purified by recrystallization. Suitable water-immiscible solvents are aromatic hydrocarbons such as benzene, chlorinated hydrocarbons, e.g. chloroform or dichloroethane, ketones, e.g. methylisobutyl ketone, esters, e.g. ethyl or amyl acetate, and ethers, e.g. diisopropyl or diethyl ether. An inactive substance containing 51.8 per <FORM:0801536/IV (b)/1> <FORM:0801536/IV (b)/2> <FORM:0801536/IV (b)/3> cent carbon, 8.90 per cent hydrogen and 39.35 per oxygen remains after the removal of the neospiramycin. Neospiramycins I, II and III may be prepared directly from the correspinding spiramycins, or from (a) spiramycin complex, and (b) a mixture of spiramycins. In the case of (a) and (b) individual neospiramycins are obtained from the mixtures of neospiramycins by countercurrent distribution or chromatography on alumina. The properties of the neospiramycins are as follows: <TABS:0801536/IV (b)/1> <TABS:0801536/IV (b)/2>
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR801536X | 1956-01-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB801536A true GB801536A (en) | 1958-09-17 |
Family
ID=9244072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB37877/56A Expired GB801536A (en) | 1956-01-11 | 1956-12-11 | Antibiotically active derivatives of spiramycins |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB801536A (en) |
-
1956
- 1956-12-11 GB GB37877/56A patent/GB801536A/en not_active Expired
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