GB798147A - Improvements in or relating to therapeutic compositions and the manufacture thereof - Google Patents

Improvements in or relating to therapeutic compositions and the manufacture thereof

Info

Publication number
GB798147A
GB798147A GB28660/56A GB2866056A GB798147A GB 798147 A GB798147 A GB 798147A GB 28660/56 A GB28660/56 A GB 28660/56A GB 2866056 A GB2866056 A GB 2866056A GB 798147 A GB798147 A GB 798147A
Authority
GB
United Kingdom
Prior art keywords
frozen
freeze
layers
therapeutic compositions
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB28660/56A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB798147A publication Critical patent/GB798147A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Solutions of e.g. therapeutic compositions containing components which if mixed in the presence of the residuum of solvent evaporated in freeze drying are gradually inactivated, are successively frozen in layers and the frozen layers are freeze-dried. An insulating layer of solvent only or a solution of an inert material such as lactose, salt or a buffer for H ions may be interposed between the layers. According to an example, an aqueous solution containing riboflavin, nicotinamide, and pantothenyl alcohol is frozen in a vial at - 40 DEG C. To the frozen product there is added an aqueous solution, at a temperature of + 5 DEG C. containing riboflavin, nicotinamide, pyridoxine hydrochloride, thiamine hydrochloride, and Vitamin B12 and the vial is again cooled to - 40 DEG C. to freeze the second solution. The frozen layered cake is freeze-dried using temperatures within the range - 30 DEG C. and + 30 DEG C. and between 50 and 200 microns of mercury pressure.
GB28660/56A 1955-09-22 1956-09-19 Improvements in or relating to therapeutic compositions and the manufacture thereof Expired GB798147A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US798147XA 1955-09-22 1955-09-22

Publications (1)

Publication Number Publication Date
GB798147A true GB798147A (en) 1958-07-16

Family

ID=22152990

Family Applications (1)

Application Number Title Priority Date Filing Date
GB28660/56A Expired GB798147A (en) 1955-09-22 1956-09-19 Improvements in or relating to therapeutic compositions and the manufacture thereof

Country Status (1)

Country Link
GB (1) GB798147A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3249504A (en) * 1962-03-13 1966-05-03 Becton Dickinson Co Multiple unit tissue culture preparation and method of preparing same
US8813955B2 (en) 2008-06-19 2014-08-26 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Container for medical products and method for production of said container

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3249504A (en) * 1962-03-13 1966-05-03 Becton Dickinson Co Multiple unit tissue culture preparation and method of preparing same
US8813955B2 (en) 2008-06-19 2014-08-26 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Container for medical products and method for production of said container

Similar Documents

Publication Publication Date Title
GB798147A (en) Improvements in or relating to therapeutic compositions and the manufacture thereof
US2135054A (en) Treatment of milk and milk preparations
GB917456A (en) Suppository composition and preparation thereof
GB1178059A (en) A process for producing Dosage Units of Medicines in Solid Form
US1658078A (en) Process of desiccation
AU204741B2 (en) Improvements in or relating tothe production of cooling arrangements for electron discharge devices, and to electron discharge devices employing such cooling arrangements
AU797755A (en) Improvements in or relating tothe production of cooling arrangements for electron discharge devices, and to electron discharge devices employing such cooling arrangements
AU1225819A (en) An improved composition substance particularly adapted for forming shaped articles such as bootheels and soles cricket balls andthe like and method of manufacturing same
GB727949A (en) Improvements in or relating to the production of selenium rectifier plates
AU212814B2 (en) "Ran improved method of manufacturing heat exchangers such as refrigerator evaporators andthe like
CA462733A (en) Composition for and method of producing phosphate films
AU128676B2 (en) Improved method and means of cooling by evaporation
AU1047155A (en) "Ran improved method of manufacturing heat exchangers such as refrigerator evaporators andthe like
CA525612A (en) Process for the manufacture of riboflavin phosphoric acid derivatives
CA525614A (en) Process for the manufacture of riboflavin phosphoric acid derivatives
CA525613A (en) Process for the manufacture of riboflavin phosphoric acid derivatives
CA525615A (en) Process for the manufacture of riboflavin phosphoric acid derivatives
AU125623B2 (en) Improvements in or relating to methods of and apparatus for depositing certain substances by thermal evaporation ina vacuum chamber
CA520152A (en) Stabilization of adenosine polyphosphoric acids
GB597158A (en) Improvements in or relating to therapeutic agents or compositions
GB732521A (en) Process for the manufacture of new dihydrazino compounds
CA520586A (en) Process for the manufacture of riboflavin phosphate
GB728688A (en) Process for the stabilisation of adenosine polyphosphoric acids
AU208243B2 (en) Method of, and composition for, treating soled materials to reduce particle adherence characteristics
ES236350A1 (en) Procedure for the manufacture of mosaic tiles or metalized analogs (Machine-translation by Google Translate, not legally binding)