GB796512A - Process for recovering an antibiotic nystatin - Google Patents

Process for recovering an antibiotic nystatin

Info

Publication number
GB796512A
GB796512A GB31091/55A GB3109155A GB796512A GB 796512 A GB796512 A GB 796512A GB 31091/55 A GB31091/55 A GB 31091/55A GB 3109155 A GB3109155 A GB 3109155A GB 796512 A GB796512 A GB 796512A
Authority
GB
United Kingdom
Prior art keywords
solvent
recovering
broth
nystatia
adjust
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB31091/55A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olin Corp
Original Assignee
Olin Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olin Corp filed Critical Olin Corp
Publication of GB796512A publication Critical patent/GB796512A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nystatin is recovered from an aqueous streptomyces noursei fermentation broth by adding to the whole broth a water-miscible organic solvent which is isopropanol, n-propanol, ethanol, methanol, or acetone, filtering the resulting mixture, removing the water-miscible solvent from the filtrate and recovering the resulting nystatia precipitate. After adding the solvent to the broth, it is preferred to adjust the pH to 4 to 6 and especially 4.5 to 5.5 by acids such as phosphoric to assist the solubilization of the nystatia in the aqueous solvent and then to adjust the pH to 6.5 to 7.5 and especially 7 by means of alkali such as sodium hydroxide in order to precipitate impurities which are filtered off. It is preferred to remove the solvent under vacuum at a temperature of up to substantially 30 DEG C. Specification 714,189 is referred to.
GB31091/55A 1954-11-04 1955-10-31 Process for recovering an antibiotic nystatin Expired GB796512A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US796512XA 1954-11-04 1954-11-04

Publications (1)

Publication Number Publication Date
GB796512A true GB796512A (en) 1958-06-11

Family

ID=22151916

Family Applications (1)

Application Number Title Priority Date Filing Date
GB31091/55A Expired GB796512A (en) 1954-11-04 1955-10-31 Process for recovering an antibiotic nystatin

Country Status (1)

Country Link
GB (1) GB796512A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103755758A (en) * 2014-01-21 2014-04-30 北京安汀医药生物科技有限公司 Preparation method of nystatin

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103755758A (en) * 2014-01-21 2014-04-30 北京安汀医药生物科技有限公司 Preparation method of nystatin
CN103755758B (en) * 2014-01-21 2016-04-27 北京安汀医药生物科技有限公司 A kind of preparation method of nystatin

Similar Documents

Publication Publication Date Title
KR940009194A (en) Method for preparing clavulanate potassium salt
GB796512A (en) Process for recovering an antibiotic nystatin
US2786781A (en) Process of recovering nystatin
GB1280729A (en) Process of recovering ammonium sulphate from an aqueous solution containing ammonium sulphate and methionine
GB1453063A (en) Method for purifying 3,5-cyclic-adenylic acid or 3,5-cyclic- deoxy-adenylic acid
GB1028921A (en) New antibiotic
GB769239A (en) Process for separating tetracycline from chlortetracycline
GB1324052A (en) Preparation of prostanoic derivatives
NL151436B (en) PROCESS FOR PREPARING AN ANTIBIOTIC BY A STREPTOMYCETE, OF THE SPECIES STREPTOMYCES RIMOSUS.
US2957864A (en) Erythromycin recovery and upgrading process
GB1294422A (en) A process for recovering pure manganese salts from manganese salt solutions containing organic impurities
GB850325A (en) Production of a new antibiotic flavensomycin
GB936314A (en) Tetracycline and chlortetracycline complexes
GB869948A (en) Process for producing glutamic acid from fermentation broth
GB758276A (en) A new antibiotic totomycin
GB883330A (en) Lysergic acid-alkaloids
GB626469A (en) Purification of antibiatic substances
GB1291948A (en) Antibiotic cp-21,635
GB1155310A (en) Process for Increasing the Yield of Tylosin Produced by Fermentation of Microorganisms.
GB712514A (en) Process for the preparation of tuberculin
GB821820A (en) Isolation and purification of the antibiotic novobiocin
ES376380A1 (en) Procedure for obtaining a new derivative of erythromycin. (Machine-translation by Google Translate, not legally binding)
GB785982A (en) Improvements in or relating to the isolation of the antibiotic neomycin
BG61266B1 (en) Method for the preparation of20-dehydro-20-deoxy-20-=(cis-3,5-dimethylpiperidine-1-il)-desmycosin
GB742634A (en) Improvements relating to the recovery of fumagillin