GB795977A - Method of preparing medicines in doses - Google Patents

Method of preparing medicines in doses

Info

Publication number
GB795977A
GB795977A GB32188/55A GB3218855A GB795977A GB 795977 A GB795977 A GB 795977A GB 32188/55 A GB32188/55 A GB 32188/55A GB 3218855 A GB3218855 A GB 3218855A GB 795977 A GB795977 A GB 795977A
Authority
GB
United Kingdom
Prior art keywords
solution
dispersion
medicine
oil
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB32188/55A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medica Oy AB
Original Assignee
Medica Oy AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medica Oy AB filed Critical Medica Oy AB
Publication of GB795977A publication Critical patent/GB795977A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A61K9/5057—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)

Abstract

A method of making medicinal capsules comprising medicines in predetermined doses dispersed in a carrier comprises preparing a solution or dispersion of the medicine in an aqueous solution of a swellable colloid, e.g., gelatin, agar-agar, gum acacia, pectin, starch, tragacanth or casein, warming the solution, e.g., to 50 DEG C. and adding dropwise to a water immiscible liquid of lower density than the solution or dispersion and which is contained in a tall cylinder, the top part of which is maintained at a temperature akin to the solution and the bottom of which is maintained at a temperature at which the colloidal carrier is solid. The droplets, as they descend the cylinder congeal to form solid "pearls" containing an amount of medicine determined by the size of each droplet. Specification 708,160 [Group VI] is referred to.ALSO:A method of preparing medicines in doses dispersed in a carrier, comprises preparing a solution or dispersion of the medicine in an aqueous solution of a swellable colloid, e.g. gelatin, agar-agar, gum acacia, pectin, starch, tragacanth or casein. This solution or dispersion is then added dropwise, after warming, e.g. to 50 DEG C., to a water-immiscible liquid of lower density than the solution or dispersion and which is also a non-solvent for the medicine, e.g. paraffin oil, or an animal or vegetable oil. This liquid is contained in a tall vertical vessel, the top part of which is maintained at a temperature similar to the colloidal dispersion or solution, e.g. 50 DEG C., and the bottom of which is at a lower temperature, e.g. 20 DEG C. On descending the vessel the drops congeal forming "pearls," containing the medicine dispersed in the carrier. The "pearls" are incompletely washed with benzene to remove part of the adhering oil, dried and washed free of all oil. Water may be removed with a water-miscible solvent, e.g. acetone, methanol, ethanol, propanol or dioxan. The colloidal solution may also contain a plasticizing agent, e.g. glucose, sorbitol, glycol or hevey. If the medicine has been incorporated in an oil form and clear "pearls" are required, resin may be added to the oil phase of the dispersion to equalize the refractive indices of the two phases. The pH of the colloidal solution or dispersion is adjusted closely to the isoelectric point of the swellable colloid used, before pouring dropwise into the congealing medium. If a cellulose derivative, e.g. carboxymethyl cellulose, is used as the carrier, the coagulating vessel may contain an aqueous solution of an acid, or an organic solvent. The example given is for a multivitamin preparation. Specification 708,160 is referred to.
GB32188/55A 1954-11-11 1955-11-10 Method of preparing medicines in doses Expired GB795977A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI795977X 1954-11-11

Publications (1)

Publication Number Publication Date
GB795977A true GB795977A (en) 1958-06-04

Family

ID=8556276

Family Applications (1)

Application Number Title Priority Date Filing Date
GB32188/55A Expired GB795977A (en) 1954-11-11 1955-11-10 Method of preparing medicines in doses

Country Status (2)

Country Link
DE (1) DE1059624B (en)
GB (1) GB795977A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3092553A (en) * 1959-01-30 1963-06-04 Jr Carl E Fisher Pharmaceutical preparations and method and apparatus for making same
DE1256194B (en) * 1961-09-05 1967-12-14 Ncr Co Manufacture of small capsules with walls made of waxy material
US3415758A (en) * 1960-03-09 1968-12-10 Ncr Co Process of forming minute capsules en masse
US3516942A (en) * 1966-09-27 1970-06-23 Ncr Co Process for drying capsule walls of hydrophilic polymeric material
US3516943A (en) * 1966-12-06 1970-06-23 Ncr Co Replacement of capsule contents by diffusion
FR2415967A1 (en) * 1978-02-06 1979-08-31 Ispytatelny Inst Med Feed-concentrate powder polymer coating - to protect against atmospheric moisture, formed by dispersing concentrate in polymer soln. and subsequently removing solvent
US4666641A (en) * 1984-06-05 1987-05-19 Universite Paris-Sud (Paris Xi) Preparation of biodegradable microcapsules based on serum albumin
US4713249A (en) * 1981-11-12 1987-12-15 Schroeder Ulf Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof
DE19537415A1 (en) * 1995-10-09 1997-04-10 New Standard Gmbh Use of drop-like vesicles to compartmentalise active components

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH630257A5 (en) * 1975-03-17 1982-06-15 Hoffmann La Roche Sustained release formulation
DE4140192C2 (en) * 1991-12-05 1996-02-29 Alfatec Pharma Gmbh Sol-controlled gelatin-based thermocolloid matrix for peroral sustained release forms
DE4221835C1 (en) * 1992-07-03 1994-03-03 Alfatec Pharma Gmbh Solid and liquid solutions of Ginkgo biloba extract

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE454386C (en) * 1924-05-27 1928-01-06 Chemische Produkte Vormals H S Process for the production of pharmaceutical and dietetic preparations in spherical form
GB402611A (en) * 1932-12-15 1933-12-07 Ferrosan As Improvements in methods and apparatus for the transformation of molten material into the form of solid round bodies
US2643209A (en) * 1951-05-16 1953-06-23 Pfizer & Co C Vitamin a acetate gelatin beadlets

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3092553A (en) * 1959-01-30 1963-06-04 Jr Carl E Fisher Pharmaceutical preparations and method and apparatus for making same
US3415758A (en) * 1960-03-09 1968-12-10 Ncr Co Process of forming minute capsules en masse
DE1256194B (en) * 1961-09-05 1967-12-14 Ncr Co Manufacture of small capsules with walls made of waxy material
US3516942A (en) * 1966-09-27 1970-06-23 Ncr Co Process for drying capsule walls of hydrophilic polymeric material
US3516943A (en) * 1966-12-06 1970-06-23 Ncr Co Replacement of capsule contents by diffusion
FR2415967A1 (en) * 1978-02-06 1979-08-31 Ispytatelny Inst Med Feed-concentrate powder polymer coating - to protect against atmospheric moisture, formed by dispersing concentrate in polymer soln. and subsequently removing solvent
US4713249A (en) * 1981-11-12 1987-12-15 Schroeder Ulf Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof
US4666641A (en) * 1984-06-05 1987-05-19 Universite Paris-Sud (Paris Xi) Preparation of biodegradable microcapsules based on serum albumin
DE19537415A1 (en) * 1995-10-09 1997-04-10 New Standard Gmbh Use of drop-like vesicles to compartmentalise active components

Also Published As

Publication number Publication date
DE1059624B (en) 1959-06-18

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