GB789369A - Mercuric-n-propylurea derivatives - Google Patents
Mercuric-n-propylurea derivativesInfo
- Publication number
- GB789369A GB789369A GB22939/56A GB2293956A GB789369A GB 789369 A GB789369 A GB 789369A GB 22939/56 A GB22939/56 A GB 22939/56A GB 2293956 A GB2293956 A GB 2293956A GB 789369 A GB789369 A GB 789369A
- Authority
- GB
- United Kingdom
- Prior art keywords
- urea
- chloromercuri
- pyrrolidinopropyl
- compounds
- mercuri
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 hydroxy-purine radical Chemical class 0.000 abstract 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- 235000013877 carbamide Nutrition 0.000 abstract 2
- 229910017464 nitrogen compound Inorganic materials 0.000 abstract 2
- 150000002830 nitrogen compounds Chemical class 0.000 abstract 2
- VPJDULFXCAQHRC-UHFFFAOYSA-N prop-2-enylurea Chemical compound NC(=O)NCC=C VPJDULFXCAQHRC-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- VXGWAWGQKJMAMN-UHFFFAOYSA-N (carbamoylamino) acetate Chemical compound CC(=O)ONC(N)=O VXGWAWGQKJMAMN-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 230000000855 fungicidal effect Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- ZQZJKHIIQFPZCS-UHFFFAOYSA-N propylurea Chemical compound CCCNC(N)=O ZQZJKHIIQFPZCS-UHFFFAOYSA-N 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- 150000003672 ureas Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/10—Mercury compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises substituted mercuripropyl ureas of formula: NH2.CO.NH.(C3H5)(Y)(HgX) where X represents an acid radical (including a hydroxy-purine radical) and Y represents -NR2, said group having a molecular weight not over 125, R being an alkyl group containing less than six carbon atoms or the two R's completing a heterocyclic ring together with the nitrogen atom. Specified "Y" groups include dimethylamino, diethylamino, dipropylamino, pyrrolidino, piperidino, morpholino, hexamethyleneimino and 4-methyl-piperazino. The compounds may be prepared by mixing or dissolving allyl urea in the nitrogen compound and the selected mercuric salt HgX2, preferably finely divided, added slowly while maintaining the reaction mixture at room temperature. Alternatively the allyl urea and nitrogen compound may be diluted with a solvent such as ethyl acetate or isopropanol and the mercuric salt also dissolved in the same solvent before addition to the other components. The compounds have diuretic, bactericidal and fungicidal properties. The examples describe the preparation of the following compounds: g -chloromercuri - b - pyrrolidino propyl urea, g -chloromercuri - b - morpholinopropyl urea, g -chloromercuri - b - piperidinopropyl urea, g -chloromercuri - b - dimethylaminopropyl urea, g - chloromercuri - b - di - n - propylaminopropyl urea, g - chloromercuri - b - hexamethyleneiminopropyl urea, g - chloromercuri - b - (1-methyl - 4 - piperazino) propyl urea, g - bromomercuri - b - pyrrolidinopropyl urea, g - sulphato - bis(mercuri - b - pyrrolidinopropyl urea) sulphate, g - acetoxymercuri - b - pyrorlidinopropyl urea acetate, g - chloromercuri - b -pyrrolidinopropyl urea theophyllinate and g -acetoxy - mercuri - b - piperidinopropyl urea.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US789369XA | 1955-08-25 | 1955-08-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB789369A true GB789369A (en) | 1958-01-22 |
Family
ID=22147124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB22939/56A Expired GB789369A (en) | 1955-08-25 | 1956-07-25 | Mercuric-n-propylurea derivatives |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE1115254B (en) |
| GB (1) | GB789369A (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2635983A (en) * | 1949-08-31 | 1953-04-21 | Lakeside Lab Inc | Propylurea-mercury compounds as diuretics |
| US2635982A (en) * | 1951-01-18 | 1953-04-21 | Lakeside Lab Inc | Mercurated allylurea derivatives and diuretics containing the same |
-
1956
- 1956-07-25 GB GB22939/56A patent/GB789369A/en not_active Expired
- 1956-08-20 DE DEA25515A patent/DE1115254B/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE1115254B (en) | 1961-10-19 |
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