GB785387A - Therapeutic fat products and the manufacture thereof - Google Patents
Therapeutic fat products and the manufacture thereofInfo
- Publication number
- GB785387A GB785387A GB23994/55A GB2399455A GB785387A GB 785387 A GB785387 A GB 785387A GB 23994/55 A GB23994/55 A GB 23994/55A GB 2399455 A GB2399455 A GB 2399455A GB 785387 A GB785387 A GB 785387A
- Authority
- GB
- United Kingdom
- Prior art keywords
- oils
- ethylene oxide
- c2h4o
- lecithin
- peanut
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 229920001451 polypropylene glycol Polymers 0.000 abstract 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 2
- 244000105624 Arachis hypogaea Species 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
- 235000019483 Peanut oil Nutrition 0.000 abstract 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 abstract 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 2
- 239000003240 coconut oil Substances 0.000 abstract 2
- 235000019864 coconut oil Nutrition 0.000 abstract 2
- -1 ethylene oxide-polypropylene Chemical group 0.000 abstract 2
- 239000000787 lecithin Substances 0.000 abstract 2
- 229940067606 lecithin Drugs 0.000 abstract 2
- 235000010445 lecithin Nutrition 0.000 abstract 2
- 239000003921 oil Substances 0.000 abstract 2
- 235000019198 oils Nutrition 0.000 abstract 2
- 239000000312 peanut oil Substances 0.000 abstract 2
- 235000000346 sugar Nutrition 0.000 abstract 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 abstract 1
- QSHVAZMOLNGWSY-UHFFFAOYSA-N 3-butyl-4-methoxyphenol Chemical group CCCCC1=CC(O)=CC=C1OC QSHVAZMOLNGWSY-UHFFFAOYSA-N 0.000 abstract 1
- 244000060011 Cocos nucifera Species 0.000 abstract 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 abstract 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 abstract 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
- 229930091371 Fructose Natural products 0.000 abstract 1
- 239000005715 Fructose Substances 0.000 abstract 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 abstract 1
- 244000068988 Glycine max Species 0.000 abstract 1
- 235000010469 Glycine max Nutrition 0.000 abstract 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 abstract 1
- 240000007817 Olea europaea Species 0.000 abstract 1
- 244000000231 Sesamum indicum Species 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 239000010775 animal oil Substances 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 239000008135 aqueous vehicle Substances 0.000 abstract 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000007859 condensation product Substances 0.000 abstract 1
- 239000002285 corn oil Substances 0.000 abstract 1
- 235000005687 corn oil Nutrition 0.000 abstract 1
- 239000002385 cottonseed oil Substances 0.000 abstract 1
- 235000012343 cottonseed oil Nutrition 0.000 abstract 1
- 239000008367 deionised water Substances 0.000 abstract 1
- 229910021641 deionized water Inorganic materials 0.000 abstract 1
- 239000008121 dextrose Substances 0.000 abstract 1
- 150000002016 disaccharides Chemical class 0.000 abstract 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 235000019197 fats Nutrition 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 125000005456 glyceride group Chemical group 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000002772 monosaccharides Chemical class 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000000346 nonvolatile oil Substances 0.000 abstract 1
- 239000004006 olive oil Substances 0.000 abstract 1
- 125000000963 oxybis(methylene) group Chemical group [H]C([H])(*)OC([H])([H])* 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 239000000473 propyl gallate Substances 0.000 abstract 1
- 229940075579 propyl gallate Drugs 0.000 abstract 1
- 235000010388 propyl gallate Nutrition 0.000 abstract 1
- 239000008159 sesame oil Substances 0.000 abstract 1
- 235000011803 sesame oil Nutrition 0.000 abstract 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 abstract 1
- 239000004299 sodium benzoate Substances 0.000 abstract 1
- 235000010234 sodium benzoate Nutrition 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
- 150000008163 sugars Chemical class 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/14—Derivatives of phosphoric acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
A therapeutic fat product suitable for oral or intravenous use comprises a metabolizable, non-toxic, fixed oil with or without a sugar emulsified in an aqueous vehicle with a minor proportion of an ethylene oxide-polypropylene glycol condensation product. Oils specified are naturally occurring animal and vegetable oils as well as synthetic glyceride oils such as olive, peanut, coconut, sesame, cotton seed and corn oils. Suitable sugars are monosaccharides such as glucose and fructose and disaccharides such as sucrose and maltose. The emulsifier is a compound of formula HO(C2H4O)a(C3H6O)b (C2H4O)cH where a, b and c are positive integers. Preferably the hydrophobic polypropylene oxide portion has a molecular weight of about 1500 to about 1800 (i.e. b equals between about 25 and about 32) and the molecule contains between about 80 and about 90 per cent of ethylene oxide (a+c equals between about 136 and about 368). Soybean phosphatides (lecithin) may also be added to improve the suspension and stability characteristics. Additional ingredients include edible antioxidants such as tert.-butyl-4-hydroxy anisole, propylgallate and citric acid, and preservatives. In an example an emulsion for oral use is prepared by dissolving dextrose, lecithin, sodium benzoate, disodium ethylene diamine tetra-acetate and the ethylene oxide-polypropylene glycol condensate in deionized water heated to 95 DEG C. Tertiary butyl-4-hydroxy anisole is dissolved in a mixture of peanut and coconut oils and the two solutions mixed and homogenized. U.S.A. Specification 2,646,354 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US785387XA | 1954-09-16 | 1954-09-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB785387A true GB785387A (en) | 1957-10-30 |
Family
ID=22144673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB23994/55A Expired GB785387A (en) | 1954-09-16 | 1955-08-19 | Therapeutic fat products and the manufacture thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB785387A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3085939A (en) * | 1959-05-11 | 1963-04-16 | Upjohn Co | Oil-in-water emulsion for oral administration, and process for preparation |
| JPS5793910A (en) * | 1980-12-02 | 1982-06-11 | Hayashibara Biochem Lab Inc | Preparation of emulsion for intravenous injection |
| GB2139889A (en) * | 1983-03-18 | 1984-11-21 | Terumo Corp | Transfusion emulsion |
-
1955
- 1955-08-19 GB GB23994/55A patent/GB785387A/en not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3085939A (en) * | 1959-05-11 | 1963-04-16 | Upjohn Co | Oil-in-water emulsion for oral administration, and process for preparation |
| JPS5793910A (en) * | 1980-12-02 | 1982-06-11 | Hayashibara Biochem Lab Inc | Preparation of emulsion for intravenous injection |
| JPS5924132B2 (en) * | 1980-12-02 | 1984-06-07 | 株式会社 林原生物化学研究所 | Manufacturing method for nutritional supplement emulsion |
| US4486417A (en) * | 1980-12-02 | 1984-12-04 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Flurocarbon-water emulsion for hyperalimentation containing maltose |
| GB2139889A (en) * | 1983-03-18 | 1984-11-21 | Terumo Corp | Transfusion emulsion |
| US5034414A (en) * | 1983-03-18 | 1991-07-23 | Terumo Kabushiki Kaisha | Liquid emulsion for transfusion |
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