GB785270A - Improvements in or relating to amide bases and salts thereof - Google Patents

Improvements in or relating to amide bases and salts thereof

Info

Publication number
GB785270A
GB785270A GB4118/56A GB411856A GB785270A GB 785270 A GB785270 A GB 785270A GB 4118/56 A GB4118/56 A GB 4118/56A GB 411856 A GB411856 A GB 411856A GB 785270 A GB785270 A GB 785270A
Authority
GB
United Kingdom
Prior art keywords
bis
diamine
referred
salts
hexamethylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4118/56A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of GB785270A publication Critical patent/GB785270A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula R2NCH2CONH(CH2)nNHCOCH2NR2, wherein R2N represents a piperidino or pyrrolidino radical, and n is an integer from 2 to 6, and acid addition salts thereof, and the preparation thereof by reacting chloroacetyl chloride with the required alkylenediamine to form a bis chloroacetyl alkylenediamine which is then reacted with an excess of piperidine or pyrrolidine at least sufficient to combine with the hydrogen chloride formed. The acid addition salts may be derived from hydrochloric, hydrobromic, phosphoric, sulphuric, lactic, acetic, succinic, fumaric and malic acids. The bismethiodide salts of compounds of the above general formula are also referred to. In the examples, N, N1-bis-chloroacetylamides are prepared from chloroacetyl chloride and ethylene-, trimethylene-, tetramethylene- and hexamethylene-diamine, the second stage of the process being exemplified by the preparation of N,N1-bis-(piperidinoacetyl) ethylene diamine, N,N1 - bis - (piperidinoacetyl) trimethylene diamine and hexamethylene diamine, the bis-methiodides of which are referred to, and N,N1-bis-(pyrrolidinoacetyl) ethylene diamine and hexamethylene diamine, the bis-methiodides thereof being referred to. Specification 701,209 also is referred to.
GB4118/56A 1955-02-24 1956-02-09 Improvements in or relating to amide bases and salts thereof Expired GB785270A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US785270XA 1955-02-24 1955-02-24

Publications (1)

Publication Number Publication Date
GB785270A true GB785270A (en) 1957-10-23

Family

ID=22144593

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4118/56A Expired GB785270A (en) 1955-02-24 1956-02-09 Improvements in or relating to amide bases and salts thereof

Country Status (1)

Country Link
GB (1) GB785270A (en)

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