GB781456A - A new hydrazine compound and a process for making it - Google Patents

A new hydrazine compound and a process for making it

Info

Publication number
GB781456A
GB781456A GB22638/53A GB2263853A GB781456A GB 781456 A GB781456 A GB 781456A GB 22638/53 A GB22638/53 A GB 22638/53A GB 2263853 A GB2263853 A GB 2263853A GB 781456 A GB781456 A GB 781456A
Authority
GB
United Kingdom
Prior art keywords
acids
dimercaptopyridazine
reacting
salts
heating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB22638/53A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba AG filed Critical Ciba AG
Publication of GB781456A publication Critical patent/GB781456A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/18—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises 3 : 6-dihydrazinopyridazine and salts thereof, together with a process for their preparation by reacting 3 : 6-dimercaptopyridazine with hydrazine and, if desired, converting the product into a salt. The products are pharmaceutically useful for reducing the blood pressure. In an example, 3 : 6-dimercaptopyridazine is refluxed with hydrazine hydrate in ethanol, and the product is converted to its acid sulphate or its mononitrate. Other acids specified for the formation of salts are hydrohalic acids, phosphoric, thiocyanic, acetic, propionic, oxalic, malonic and succinic acids, hydroxyethane-, benzene- and toluene-sulphonic acids, and therapeutically active acids. Starting material. 3 : 6-Dimercaptopyridazine is prepared by heating 3 : 6-dihydroxypyridazine with POCl3 and reacting the resulting 3 : 6-dichlorpyridazine with potassium sulphide (e.g. by heating in a bomb tube in ethanolic solution).
GB22638/53A 1952-08-20 1953-08-17 A new hydrazine compound and a process for making it Expired GB781456A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH781456X 1952-08-20

Publications (1)

Publication Number Publication Date
GB781456A true GB781456A (en) 1957-08-21

Family

ID=4536249

Family Applications (1)

Application Number Title Priority Date Filing Date
GB22638/53A Expired GB781456A (en) 1952-08-20 1953-08-17 A new hydrazine compound and a process for making it

Country Status (1)

Country Link
GB (1) GB781456A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3205230A (en) * 1962-09-14 1965-09-07 Olin Mathieson 3-substituted-5, 6, 7, 8, 9, 10-hexahydro-cycloocta[c] pyridazines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3205230A (en) * 1962-09-14 1965-09-07 Olin Mathieson 3-substituted-5, 6, 7, 8, 9, 10-hexahydro-cycloocta[c] pyridazines

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