GB768778A - Chloral derivatives and methods for their preparation - Google Patents
Chloral derivatives and methods for their preparationInfo
- Publication number
- GB768778A GB768778A GB11041/55A GB1104155A GB768778A GB 768778 A GB768778 A GB 768778A GB 11041/55 A GB11041/55 A GB 11041/55A GB 1104155 A GB1104155 A GB 1104155A GB 768778 A GB768778 A GB 768778A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hemiacetal
- chloral
- tetrachloral
- hexachloral
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
Abstract
The invention comprises a hemiacetal of chloral with a non-toxic polyhydric alcohol having the formula R(OH)n, where R represents a saturated aliphatic hydrocarbon group having from 3 to 6 carbon atoms and n represents an integer from 3 to 6, said hemiacetal having the formula <FORM:0768778/IV(b)/1> where x represents an integer from 3 to 6 which is never greater than n. Such compounds are obtained by heating a mixture of the alcohol and x equivalents of chloral under anhydrous conditions at the temperature of reflux of chloral from the mixture until the point of constant reflux rate is reached and then cooling the mixture. Examples describe the preparation by such a method of (1) pentaerythritol tetrachloral hemiacetal; (2) mannitol tetrachloral hemiacetal; (3) sorbitol tetrachloral hemiacetal; (4) mannitol hexachloral hemiacetal; (5) sorbitol hexachloral hemiacetal; (6) glycerol trichloral hemiacetal; (7) pentaerythritol trichloral hemiacetal.ALSO:A therapeutic sedative and hypnotic composition comprises a hemiacetal of chloral with a non-toxic polyhydric alcohol having the formula R(OH)n, where R represents a saturated aliphatic hydrocarbon group having 3 to 6 carbon atoms and n represents an integer from 3 to 6, said hemiacetal having the formula:- <FORM:0768778/VI/1> where x represents an integer from 3 to 6 which is never greater than n, together with a carrier. The compounds can be formed into dosage forms such as tablets, capsules or suppositories with carriers, binders and excipients. Specific compounds, the preparation of which is described (see Group IV(b)) are pentaerythritol tri- and tetrachloral hemiacetals, mannitol tetra- and hexachloral hemiacetals, sorbitol tetra- and hexachloral hemiacetals, and glycerol trichloral hemiacetal.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US768778XA | 1954-06-16 | 1954-06-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB768778A true GB768778A (en) | 1957-02-20 |
Family
ID=22134712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB11041/55A Expired GB768778A (en) | 1954-06-16 | 1955-04-18 | Chloral derivatives and methods for their preparation |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB768778A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4394306A (en) * | 1980-05-23 | 1983-07-19 | Imi (Tami) Institute For Research & Development Ltd. | Bromine containing fire retardant compositions of matter |
-
1955
- 1955-04-18 GB GB11041/55A patent/GB768778A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4394306A (en) * | 1980-05-23 | 1983-07-19 | Imi (Tami) Institute For Research & Development Ltd. | Bromine containing fire retardant compositions of matter |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES468325A1 (en) | Process for the preparation of low molecular weight polyhydroxyl compounds | |
ES371463A1 (en) | 2-thiopyrimidine nucleosides | |
FR2401126A1 (en) | VAPOR PHASE DEHYDRATION PROCESS OF ALKYLBENZYL ALCOHOLS | |
GB768778A (en) | Chloral derivatives and methods for their preparation | |
ES390895A1 (en) | Esters of phenylalanine | |
ES399873A1 (en) | 1-phenoxy-2-hydroxy-3-hydroxyalkylamino-propanes an processes for their preparation | |
ES391993A1 (en) | Basically substituted alkyl theophyllines | |
ES394137A1 (en) | Process for the production of alkylated n,n.-diphenyl-oxamides | |
FR1019552A (en) | Method for preparing streptomycin fatty acid salts | |
ES396174A1 (en) | Phenylethanolamine derivatives | |
ES397037A1 (en) | Method of preparation of purine sugar derivatives | |
ES358130A1 (en) | A procedure for the preparation of nitrofurilnitronas. (Machine-translation by Google Translate, not legally binding) | |
ES399200A1 (en) | Procedure for preparation of new tetrahydropirimidinic compounds. (Machine-translation by Google Translate, not legally binding) | |
GB772808A (en) | Chloral derivatives and methods for their preparation | |
ES281441A1 (en) | A procedure for the manufacture of pharmaceutical compounds (Machine-translation by Google Translate, not legally binding) | |
FR876816A (en) | Process for the preparation of cyclic acetals derived from ketosteroids | |
ES284285A1 (en) | Procedure for preparation of 6- (5-nitro-2-furil) -uracilo (Machine-translation by Google Translate, not legally binding) | |
ES282864A1 (en) | Procedure for the preparation of 4-isoxazolin-3-onas (Machine-translation by Google Translate, not legally binding) | |
ES210272A1 (en) | A procedure for the purification of cimethylformamide (Machine-translation by Google Translate, not legally binding) | |
GB1047009A (en) | A process for the manufacture of oxazoles | |
GB928637A (en) | Process for the preparation of dialkyl isocyanurates | |
ES294010A2 (en) | A procedure for the preparation of pharmaceutical compounds (Machine-translation by Google Translate, not legally binding) | |
ES353506A1 (en) | Procedure for preparing cicloalcanofenoxialcanolaminas. (Machine-translation by Google Translate, not legally binding) | |
ES408237A1 (en) | 1,2-diphenyl-3,6-dioxo-4-hydroxy-5-n-butyl-tetrahydropyridazine | |
FR1269053A (en) | Process for preparing 9-halogenated derivatives of delta1.4-3.20-diketo-17-hydroxy-11.21-bis-oxy-pregnadiene compounds |