GB772808A - Chloral derivatives and methods for their preparation - Google Patents

Chloral derivatives and methods for their preparation

Info

Publication number
GB772808A
GB772808A GB21396/55A GB2139655A GB772808A GB 772808 A GB772808 A GB 772808A GB 21396/55 A GB21396/55 A GB 21396/55A GB 2139655 A GB2139655 A GB 2139655A GB 772808 A GB772808 A GB 772808A
Authority
GB
United Kingdom
Prior art keywords
glucose
chloral
hemiacetal
lactose
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB21396/55A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of GB772808A publication Critical patent/GB772808A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms

Abstract

The invention comprises a hemiacetal of chloral with glucose, 3-methyl-glucose or lactose, said hemiacetal containing at least four chloral groups per molecule. Such hermiacetals, which contain 4 or 5 chloral groups per molecule in the case of glucose or 3-methyl glucose and 4 chloral groups in the case of lactose are obtained by heating a mixture of the sugar and the required number of equivalents of chloral under anhydrous conditions at the temperature of reflux of chloral from the mixture until the point of constant reflux rate (i.e. the stage at which reflux is at a minimum) is reached and then cooling the mixture. In Example (1), glucose pentachloral hemiacetal is prepared by refluxing glucose with 5 molecular proportions of chloral at about 120 DEG C. until the point of constant reflux rate is reached. Similarly produced are (2) 3-methyl glucose pentachloral hemiacetal; (3) lactose tetrachloral hemiacetal; (4) glucose tetrachloral hemiacetal.ALSO:A therapeutic sedative and hypnotic composition comprises a carrier and a hemicetal of chloral with glucose, 3 - methyl-glucose or lactose, the hemiacetal containing at least four chloral groups per molecule. The composition may be in the form of capsules, tablets and suppositories with carriers, binders and excipients. The preparation of the hemiacetals is described (see Group IV(b)).
GB21396/55A 1954-07-27 1955-07-25 Chloral derivatives and methods for their preparation Expired GB772808A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US772808XA 1954-07-27 1954-07-27

Publications (1)

Publication Number Publication Date
GB772808A true GB772808A (en) 1957-04-17

Family

ID=22137149

Family Applications (1)

Application Number Title Priority Date Filing Date
GB21396/55A Expired GB772808A (en) 1954-07-27 1955-07-25 Chloral derivatives and methods for their preparation

Country Status (1)

Country Link
GB (1) GB772808A (en)

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