GB767777A - "composition for combating trichuris infection of mammals" - Google Patents
"composition for combating trichuris infection of mammals"Info
- Publication number
- GB767777A GB767777A GB29636/54A GB2963654A GB767777A GB 767777 A GB767777 A GB 767777A GB 29636/54 A GB29636/54 A GB 29636/54A GB 2963654 A GB2963654 A GB 2963654A GB 767777 A GB767777 A GB 767777A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- pentyn
- phthalate
- acid
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
3-Methyl-1-pentyn-3-ol is reacted with phthalic anhydride in the presence of pyridine. The cooled reaction mixture is diluted with water, acidified with hydrochloric acid and allowed to crystallize to give 3-methyl-1-pentyn-3-yl acid phthalate <FORM:0767777/IV(b)/1> This compound may be reacted with sodium carbonate, potassium carbonate, calcium carbonate, ammonia, monoethanolamine, diethanolamine and ethylene diamine to give the respective salts. The acid phthalate and/or its salts may be used as anthelminthics in medicine (see Group VI).ALSO:Compositions for combating Trichuris infection of mammals comprise 3 - methyl-1 - pentyn - 3 - yl phthalate <FORM:0767777/VI/1> and/or non toxic salts thereof. A non-toxic pharmaceutical carrier which may be water, glycerol, non-toxic glycols, alcohol or mixtures thereof: or talc, lactose, corn starch, stearic acid, magnesium stearate, methyl cellulose and vegetable gums may also be present. The preparation may be in the form of a solution, suspension, tincture, elixir or emulsion or tablet, capsule, powder, soft pill or coated granule. In an example 3 - methyl - 1 - pentyn - 3 - yl acid phthalate is granulated with starch and acacia, the granules mixed with starch, talc and magnesium stearate and the mixture tabletted.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US767777XA | 1953-11-19 | 1953-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB767777A true GB767777A (en) | 1957-02-06 |
Family
ID=22134120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB29636/54A Expired GB767777A (en) | 1953-11-19 | 1954-10-14 | "composition for combating trichuris infection of mammals" |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE533428A (en) |
| GB (1) | GB767777A (en) |
| NL (1) | NL88696C (en) |
-
0
- BE BE533428D patent/BE533428A/xx unknown
-
1954
- 1954-10-14 GB GB29636/54A patent/GB767777A/en not_active Expired
- 1954-11-05 NL NL192118A patent/NL88696C/xx active
Also Published As
| Publication number | Publication date |
|---|---|
| BE533428A (en) | |
| NL88696C (en) | 1958-07-15 |
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