GB760114A - Improvements in and relating to compositions for lowering the cholesterol level in the blood serum - Google Patents

Improvements in and relating to compositions for lowering the cholesterol level in the blood serum

Info

Publication number
GB760114A
GB760114A GB1707753A GB1707753A GB760114A GB 760114 A GB760114 A GB 760114A GB 1707753 A GB1707753 A GB 1707753A GB 1707753 A GB1707753 A GB 1707753A GB 760114 A GB760114 A GB 760114A
Authority
GB
United Kingdom
Prior art keywords
group
alkyl
lowering
sodium
blood serum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1707753A
Inventor
Jean Cottet
Joseph Redel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chimie et Atomistique SA
Original Assignee
Chimie et Atomistique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chimie et Atomistique SA filed Critical Chimie et Atomistique SA
Priority to GB1707753A priority Critical patent/GB760114A/en
Publication of GB760114A publication Critical patent/GB760114A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/126—Acids containing more than four carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/126—Acids containing more than four carbon atoms
    • C07C53/128—Acids containing more than four carbon atoms the carboxylic group being bound to a carbon atom bound to at least two other carbon atoms, e.g. neo-acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A composition for lowering the cholesterol level in the blood serum comprises a compound of formula <FORM:0760114/VI/1> where R represents an alkyl or aryl radical, R1 represents hydrogen or an alkyl radical. R2 represents an alkyl or alkylene radical, m is 0 or 1 and X is an OH group, a group OMn where M is an alkali metal, an alkaline earth metal, aluminium or magnesium and n such that nx (valency of M) = 1, and OB group, B being the cation of an organic base, or an NH2 group, together with a therapeutically inactive and non-toxic solid or semi-solid vehicle, an isotonic solution or a fatty oil. Specified compounds include sodium phenylethyl acetate, phenylethylacetamide, sodium phenyl methylacetate, and sodium phenylethyl propionate. The active compound may be mixed with starch, magnesium stearate or talc to form tablets, with cocoa butter to form suppositories or isotonic solutions or fatty oils for parenteral injection. In an example tablets are prepared from a composition comprising phenylethylacetamide, starch, magnesium stearate and talc.
GB1707753A 1953-06-19 1953-06-19 Improvements in and relating to compositions for lowering the cholesterol level in the blood serum Expired GB760114A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1707753A GB760114A (en) 1953-06-19 1953-06-19 Improvements in and relating to compositions for lowering the cholesterol level in the blood serum

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1707753A GB760114A (en) 1953-06-19 1953-06-19 Improvements in and relating to compositions for lowering the cholesterol level in the blood serum

Publications (1)

Publication Number Publication Date
GB760114A true GB760114A (en) 1956-10-31

Family

ID=10088836

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1707753A Expired GB760114A (en) 1953-06-19 1953-06-19 Improvements in and relating to compositions for lowering the cholesterol level in the blood serum

Country Status (1)

Country Link
GB (1) GB760114A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3061634A (en) * 1959-02-17 1962-10-30 Francesco Angelini Halo and phenyl substituted phenyl lower alkyl carbinol mono esters of succinic, glutaric, and maleic acids
FR2209555A1 (en) * 1972-12-11 1974-07-05 Labaz
US3969508A (en) * 1974-11-27 1976-07-13 Smithkline Corporation Lowering the concentration of plasma triglycerides
EP0005422A2 (en) * 1978-05-03 1979-11-14 Sanofi S.A. Derivatives of omega-dialkylalkanoic acids, processes for their preparation and their therapeutical use
US4246282A (en) 1979-06-07 1981-01-20 Labaz ω-Dialkylalkanoic acid derivatives used to induce antianoxic activity
US5017613A (en) * 1983-07-20 1991-05-21 Sanofi, S. A. Valproic acid preparations

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3061634A (en) * 1959-02-17 1962-10-30 Francesco Angelini Halo and phenyl substituted phenyl lower alkyl carbinol mono esters of succinic, glutaric, and maleic acids
FR2209555A1 (en) * 1972-12-11 1974-07-05 Labaz
US3969508A (en) * 1974-11-27 1976-07-13 Smithkline Corporation Lowering the concentration of plasma triglycerides
EP0005422A2 (en) * 1978-05-03 1979-11-14 Sanofi S.A. Derivatives of omega-dialkylalkanoic acids, processes for their preparation and their therapeutical use
EP0005422A3 (en) * 1978-05-03 1979-12-12 Sanofi, Societe Anonyme Derivatives of omega-dialkylalkanoic acids, processes for their preparation and their therapeutical use
US4246282A (en) 1979-06-07 1981-01-20 Labaz ω-Dialkylalkanoic acid derivatives used to induce antianoxic activity
US5017613A (en) * 1983-07-20 1991-05-21 Sanofi, S. A. Valproic acid preparations

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