GB754687A - New carbamic acid esters and their production - Google Patents
New carbamic acid esters and their productionInfo
- Publication number
- GB754687A GB754687A GB26644/54A GB2664454A GB754687A GB 754687 A GB754687 A GB 754687A GB 26644/54 A GB26644/54 A GB 26644/54A GB 2664454 A GB2664454 A GB 2664454A GB 754687 A GB754687 A GB 754687A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbamic acid
- amine
- acid esters
- phenyl
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises carbamic acid esters of the formula <FORM:0754687/IV(a)/1> wherein Ar is phenyl or alkyl substituted phenyl, R1 is a hydrogen atom or alkyl group, R2 is an alkylene group containing at most 4 carbon atoms and Am is a dialkylamino group or the radical of a saturated heterocyclic amine attached to R2 at a ring nitrogen atom, and their salts with inorganic and organic acids; and their preparation by reacting an amine <FORM:0754687/IV(a)/2> with a halogeno carbonic acid halogenoalkyl ester <FORM:0754687/IV(a)/3> (wherein X and X1 are halogen atoms) in the presence of a tertiary amine and reacting the thus obtained carbamic acid ester with an amine AmH at elevated temperature. The conversion to salts can be carried out by dissolving the carbamic acid esters in an organic solvent such as alcohol, ether or acetone and then treating them with an etheric, alcoholic or acetonic solution of the desired acid. Examples describe the preparation of compounds of the above general formula in which Ar is phenyl, o-tolyl, 3 : 5-xylyl or mesityl, R1 is hydrogen, methyl or ethyl, R2 is ethylene or propylene and Am is diethylamino, piperidino, pyrrolidino, morpholino or a -pipecolino, the tertiary amine reagent in each case being triethylamine. The products are useful as local anaesthetics.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE754687X | 1954-06-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB754687A true GB754687A (en) | 1956-08-08 |
Family
ID=6659410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB26644/54A Expired GB754687A (en) | 1954-06-11 | 1954-09-14 | New carbamic acid esters and their production |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB754687A (en) |
-
1954
- 1954-09-14 GB GB26644/54A patent/GB754687A/en not_active Expired
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