GB751437A - A method of increasing the vitamin e biological activity of -a-tocopherol - Google Patents
A method of increasing the vitamin e biological activity of -a-tocopherolInfo
- Publication number
- GB751437A GB751437A GB19978/54A GB1997854A GB751437A GB 751437 A GB751437 A GB 751437A GB 19978/54 A GB19978/54 A GB 19978/54A GB 1997854 A GB1997854 A GB 1997854A GB 751437 A GB751437 A GB 751437A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tocopherol
- hydrogen chloride
- per cent
- total
- normality
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The Vitamin E activity of b -tocopherol is increased by chloromethylating it in a tocopherolcontaining phase, the hydrogen chloride normality of which is from 0.8 N to 1.0 N, and reducing the chloromethylated product. The chloromethylation may be effected by means of formaldehyde, paraformaldehyde or dimethyl formal in conjunction with the hydrogen chloride, or by means of chloromethyl ether. The desired hydrogen chloride normality during this step is advantageously achieved by treating the b -tocopherol in a non-aqueous organic solvent phase in contact with an aqueous acid phase, the total hydrogen chloride normality in the mixed phases being adjusted to 4-5 N, e.g. by passing in gaseous hydrogen chloride. The reduction step may be effected by hydrogenation in the presence of Raney nickel at moderate pressures or by adding zinc dust to the acidic reaction mixture. The process is applicable especially to the treatment of compositions containing at least 50 per cent of b -tocopherol, e.g. the product obtained from a composition containing a substantial amount of d -tocopherol by converting said d -tocopherol to a mixture of b - and a -tocopherols and separating the former from the latter. Examples describe the treatment of (1) a concentrate in which 76.5 per cent of the total tocopherol content is b -tocopherol, dissolved in diethyl ether; (2) a concentrate in which 86 per cent of the total tocopherol content is b -tocopherol, dissolved in isopropyl ether. Specifications 639,011, 676,853 and 681,508 are referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US751437XA | 1953-07-13 | 1953-07-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB751437A true GB751437A (en) | 1956-06-27 |
Family
ID=22123831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB19978/54A Expired GB751437A (en) | 1953-07-13 | 1954-07-08 | A method of increasing the vitamin e biological activity of -a-tocopherol |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB751437A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107935980A (en) * | 2017-11-24 | 2018-04-20 | 宁波大红鹰生物工程股份有限公司 | A kind of production technology of D alpha tocopherols |
-
1954
- 1954-07-08 GB GB19978/54A patent/GB751437A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107935980A (en) * | 2017-11-24 | 2018-04-20 | 宁波大红鹰生物工程股份有限公司 | A kind of production technology of D alpha tocopherols |
| CN107935980B (en) * | 2017-11-24 | 2021-06-18 | 宁波大红鹰生物工程股份有限公司 | Production process of D-alpha-tocopherol |
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