GB728383A - Ion exchange resin indicator compounds - Google Patents

Ion exchange resin indicator compounds

Info

Publication number
GB728383A
GB728383A GB4675/51A GB467551A GB728383A GB 728383 A GB728383 A GB 728383A GB 4675/51 A GB4675/51 A GB 4675/51A GB 467551 A GB467551 A GB 467551A GB 728383 A GB728383 A GB 728383A
Authority
GB
United Kingdom
Prior art keywords
ion
resin
indicator
ions
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4675/51A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SECURITY TRUST CO OF ROCHESTER
Original Assignee
SECURITY TRUST CO OF ROCHESTER
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SECURITY TRUST CO OF ROCHESTER filed Critical SECURITY TRUST CO OF ROCHESTER
Publication of GB728383A publication Critical patent/GB728383A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/04—Processes using organic exchangers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A non-toxic ion-exchange resin indicator compound, for determining whether the pH of gastric juice in a stomach is above or below a predetermined value, comprises an ion-exchange complex synthetic polymer resin having associated therewith 0.04-0.5 millimoles of displaceable and readily identifiable ions per dose, the amount of indicator ion per gram of ion-exchange resin being less than the total capacity of the resin. The dose is administered orally and if the hydrochloric acid concentration is above a certain value, the ions are displaced and appear in body fluids, for example, urine, blood, saliva or sweat. The concentration of ion in the resin varies depending on the size of the dose, which may be from 1-50 grams. Suitable cation or anion exchange resins are those available under the Registered Trade Marks "Amberlite" and "Permutit." The displaceable ions may be cations or anions; in examples, indicator compounds are prepared by treating resins with (1) quinine hydrochloride; (2) tetramethylaminophenothiazinium chloride (methylene blue); (3) 2, 4-diamino-41-ethoxyazobenzene monohydrochloride (serenium); (4) sodium fluorescein (uranin); (5) potassium iodide or potassium thiocyanate. Tests are described in which the indicator compounds are mixed with solutions of hydrochloric acid and gastric juice of varying pH values.
GB4675/51A 1950-02-25 1951-02-26 Ion exchange resin indicator compounds Expired GB728383A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US316613XA 1950-02-25 1950-02-25
CH303819T 1951-02-26

Publications (1)

Publication Number Publication Date
GB728383A true GB728383A (en) 1955-04-20

Family

ID=25734676

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4675/51A Expired GB728383A (en) 1950-02-25 1951-02-26 Ion exchange resin indicator compounds

Country Status (3)

Country Link
CH (1) CH316613A (en)
FR (1) FR1041630A (en)
GB (1) GB728383A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3449080A (en) * 1964-10-29 1969-06-10 Johnson & Johnson Device for determining sodium or chloride concentration in body fluids
WO2007144048A2 (en) * 2006-06-12 2007-12-21 Dsm Fine Chemicals Austria Nfg Gmbh & Co. Kg Presentation form for the oral administration of phenothiazine dyes, its production and use
WO2009007376A1 (en) * 2007-07-09 2009-01-15 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Pharmaceutical compositions for peroral administration of phenothiazine dyestuffs

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988008137A1 (en) * 1987-04-10 1988-10-20 The Flinders University Of South Australia Determination of ions in fluids

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3449080A (en) * 1964-10-29 1969-06-10 Johnson & Johnson Device for determining sodium or chloride concentration in body fluids
WO2007144048A2 (en) * 2006-06-12 2007-12-21 Dsm Fine Chemicals Austria Nfg Gmbh & Co. Kg Presentation form for the oral administration of phenothiazine dyes, its production and use
WO2007144048A3 (en) * 2006-06-12 2008-12-24 Dsm Fine Chem Austria Gmbh Presentation form for the oral administration of phenothiazine dyes, its production and use
WO2009007376A1 (en) * 2007-07-09 2009-01-15 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Pharmaceutical compositions for peroral administration of phenothiazine dyestuffs

Also Published As

Publication number Publication date
FR1041630A (en) 1953-10-26
CH316613A (en) 1956-10-15

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