GB716700A - A new and improved analgesic and process for its production - Google Patents
A new and improved analgesic and process for its productionInfo
- Publication number
- GB716700A GB716700A GB28522/52A GB2852252A GB716700A GB 716700 A GB716700 A GB 716700A GB 28522/52 A GB28522/52 A GB 28522/52A GB 2852252 A GB2852252 A GB 2852252A GB 716700 A GB716700 A GB 716700A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- ester
- group
- benzilic
- treated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000000202 analgesic effect Effects 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 10
- 229940087675 benzilic acid Drugs 0.000 abstract 6
- UKXSKSHDVLQNKG-UHFFFAOYSA-N benzilic acid Chemical compound C=1C=CC=CC=1C(O)(C(=O)O)C1=CC=CC=C1 UKXSKSHDVLQNKG-UHFFFAOYSA-N 0.000 abstract 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 5
- 150000002148 esters Chemical class 0.000 abstract 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 4
- 235000019441 ethanol Nutrition 0.000 abstract 4
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- -1 1 - dimethylaminoethyl ester Chemical class 0.000 abstract 2
- UJRMHFPTLFNSTA-UHFFFAOYSA-N 2-chloro-2,2-diphenylacetic acid Chemical compound C=1C=CC=CC=1C(Cl)(C(=O)O)C1=CC=CC=C1 UJRMHFPTLFNSTA-UHFFFAOYSA-N 0.000 abstract 2
- WQMAANNAZKNUDL-UHFFFAOYSA-N 2-dimethylaminoethyl chloride Chemical compound CN(C)CCCl WQMAANNAZKNUDL-UHFFFAOYSA-N 0.000 abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 2
- UEEJHVSXFDXPFK-UHFFFAOYSA-N N-dimethylaminoethanol Chemical compound CN(C)CCO UEEJHVSXFDXPFK-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 abstract 2
- 239000007795 chemical reaction product Substances 0.000 abstract 2
- 229960002887 deanol Drugs 0.000 abstract 2
- 230000032050 esterification Effects 0.000 abstract 2
- 238000005886 esterification reaction Methods 0.000 abstract 2
- 238000006266 etherification reaction Methods 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 150000001447 alkali salts Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 238000010533 azeotropic distillation Methods 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 125000006267 biphenyl group Chemical group 0.000 abstract 1
- 229910000019 calcium carbonate Inorganic materials 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000002739 metals Chemical class 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 150000002902 organometallic compounds Chemical class 0.000 abstract 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000005809 transesterification reaction Methods 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE313875X | 1951-11-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB716700A true GB716700A (en) | 1954-10-13 |
Family
ID=6142940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB28522/52A Expired GB716700A (en) | 1951-11-14 | 1952-11-12 | A new and improved analgesic and process for its production |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE515454A (enrdf_load_stackoverflow) |
| CH (1) | CH313875A (enrdf_load_stackoverflow) |
| FR (1) | FR1078375A (enrdf_load_stackoverflow) |
| GB (1) | GB716700A (enrdf_load_stackoverflow) |
| NL (1) | NL84813C (enrdf_load_stackoverflow) |
-
0
- BE BE515454D patent/BE515454A/xx unknown
- NL NL84813D patent/NL84813C/xx active
-
1952
- 1952-11-11 CH CH313875D patent/CH313875A/de unknown
- 1952-11-12 GB GB28522/52A patent/GB716700A/en not_active Expired
- 1952-11-12 FR FR1078375D patent/FR1078375A/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH313875A (de) | 1956-05-15 |
| BE515454A (enrdf_load_stackoverflow) | |
| NL84813C (enrdf_load_stackoverflow) | |
| FR1078375A (fr) | 1954-11-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3716583A (en) | Phenoxy carboxylic acid derivative | |
| US3586713A (en) | Amides and n-hydroxyamides of substituted arylacetic acids and corresponding salts | |
| MX3174E (es) | Procedimiento para la preparacion de amidas de acido 2 , 4 , 6 - tri yodo - isoftalico , facilmente solubles en el agua | |
| GB799271A (en) | Production of intermediates for the synthesis of reserpine and allied compounds | |
| CN109970580B (zh) | 一种r-3-氨基丁醇的提取制备方法 | |
| ES408180A1 (es) | Un procedimiento para la preparacion de esteres de alcaloi-des del tipo de la eburnamina. | |
| GB716700A (en) | A new and improved analgesic and process for its production | |
| Walborsky et al. | Reaction of Ezo-norbornylene Oxide with Hydrogen Bromide | |
| US2653955A (en) | Cortisone esters and process | |
| US3075997A (en) | 3, 5-dihydroxy-3-fluoro-methylpentanoic acid and the delta lactone thereof | |
| US2153591A (en) | Process for the production of salts of beta-methylcholine and acyl derivatives thereof | |
| US2897206A (en) | Dialkylamides of alpha-(4-antipyrylamino)-fatty acids and their n-alkyl derivatives | |
| US3014925A (en) | Unsaturated mevalonic acid | |
| US3168552A (en) | 3-(2-isopentenyl)-4-hydroxy benzoic acid and derivatives and preparation thereof | |
| US3852333A (en) | New anthranilic acid{60 -monoglycerides | |
| GB560081A (en) | A process for the manufacture of new unsaturated alcohols | |
| GB553317A (en) | Improvements in the production of alkaline earth metal pantothenates | |
| US2537868A (en) | Water-soluble salts of diethyl-stilbestrol di-(sulfoacetate) and process for the manufacture thereof | |
| SU622395A3 (ru) | Способ получени аминов или их солей | |
| US2915522A (en) | N-tbeta-methyl-mercapto-ethyl | |
| US3139434A (en) | 10-substituted yohimbanes | |
| US3055937A (en) | Substituted glycineamides | |
| SU459461A1 (ru) | Способ получени диэтаноламиноэтилового эфира алкилен нтарной кислоты | |
| JPS5813539B2 (ja) | チカンテトラゾ−ルシボウサンルイノ セイゾウホウ | |
| JPS6052710B2 (ja) | ７−メトキシセフアロスポリン誘導体の製造法 |