GB715424A - Improvements in n-acyl derivatives of iminodibenzyl and in their preparation - Google Patents
Improvements in n-acyl derivatives of iminodibenzyl and in their preparationInfo
- Publication number
- GB715424A GB715424A GB17383/52A GB1738352A GB715424A GB 715424 A GB715424 A GB 715424A GB 17383/52 A GB17383/52 A GB 17383/52A GB 1738352 A GB1738352 A GB 1738352A GB 715424 A GB715424 A GB 715424A
- Authority
- GB
- United Kingdom
- Prior art keywords
- iminodibenzyl
- propionyl
- butyryl
- carbon atoms
- dimethylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Hydrogenated Pyridines (AREA)
Abstract
The invention comprises N-acyl derivatives of iminodibenzyl of the formula: <FORM:0715424/IV (b)/1> or salts thereof with organic or inorganic acids, wherein X represents a divalent saturated aliphatic radical containing not more than five carbon atoms and Am represents the radical of a secondary amine consisting of NH and two aliphatic hydrocarbon radicals, each containing not more than five carbon atoms, the radical of a tri-(lower alkyl)-ethylene-diamine, the lower alkyl radical containing not more than three carbon atoms, or the radical of an alkylene imine having five or six ring members. The compounds are prepared by reacting an N-(halogenalkanoyl)-iminodibenzyl, produced by acylating iminodibenzyl with reactive halogen fatty acid derivatives, with a secondary amine consisting of NH and two aliphatic hydrogen radicals, each containing not more than five carbon atoms, with a tri-(lower alkyl)-ethylene diamine, the lower alkyl radical containing not more than three carbon atoms, or with an alkylene imine having five or six ring members, in an inert solvent (e.g. benzene or homologues thereof) and in presence of an acid-binding agent such as an organic tertiary base (e.g. dimethyl aniline or pyridine), a suitable inorganic binding agent (e.g. sodium or potassium carbonate) or an excess of the amine used for the reaction. Lists of suitable starting materials are specified. The examples describe the preparation of N-(a -diethylamino-propionyl) - iminodibenzyl, N - (a - piperidino-propionyl) - iminodibenzyl, N - [a - (N1 - di-methylaminoethyl - N1 - methyl - amino)-propionyl] - iminodibenzyl, N - a - (pyrrolidino-propionyl) - iminodibenzyl, N - (a - dimethyl-amino - butyryl) - iminodibenzyl, N - [a - (di-ethylaminoethyl - N1 - ethyl - amino) - butyryl]-iminodibenzyl, N - (a - piperidino - butyryl)-iminodibenzyl, N - (dimethylamino - acetyl)-iminodibenzyl, N - (diethylamino - acetyl)-iminodibenzyl, N - (N1 - diethylaminoethyl-N1-ethylamino - acetyl) - iminodibenzyl, N - di-allyl - aminoacetyl - iminodibenzyl, N - dibutylaminoacetyl - iminodibenzyl, N - piperidinoacetyl - iminodibenzyl, N - (a - dimethylamino-propionyl) - iminodibenzyl, N - (b - dimethylamino - propionyl) - iminodibenzyl, N - (b -diethylamino - propionyl) - iminodibenzyl, N-(b - piperidino - propionyl) - iminodibenzyl, N - (b - diallylamino - propionyl) - iminodibenzyl, N - [b - (N1 - diethylaminoethyl - N1-ethylamino) - propionyl] - iminodibenzyl, N-(b - dimethylamino - butyryl) - iminodibenzyl, N - (b - pyrrolidino - butyryl) - iminodibenzyl, and N - [b - (N1 - dimethylaminoethyl - N1-methylamino) - butyryl] - iminodibenzyl. N - (halogen - alkanoyl) - iminodibenzyls are prepared by acylating iminodibenzyl with halogen fatty acid halides or the corresponding anhydrides in the presence or absence of, for example, pyridine or dimethyl aniline. The following are prepared or employed as starting materials in the examples: N-chloracetyl-, N-a - bromopropionyl -, N - a - bromobutyryl -, N - b - bromopropionyl -, and N - b - bromobutyryl-iminodibenzyl. Others are mentioned as suitable starting materials.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH715424X | 1951-07-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB715424A true GB715424A (en) | 1954-09-15 |
Family
ID=4531065
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB17383/52A Expired GB715424A (en) | 1951-07-11 | 1952-07-10 | Improvements in n-acyl derivatives of iminodibenzyl and in their preparation |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB715424A (en) |
-
1952
- 1952-07-10 GB GB17383/52A patent/GB715424A/en not_active Expired
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