GB687556A - Salts of riboflavin phosphate and the manufacture thereof - Google Patents
Salts of riboflavin phosphate and the manufacture thereofInfo
- Publication number
- GB687556A GB687556A GB21143/51A GB2114351A GB687556A GB 687556 A GB687556 A GB 687556A GB 21143/51 A GB21143/51 A GB 21143/51A GB 2114351 A GB2114351 A GB 2114351A GB 687556 A GB687556 A GB 687556A
- Authority
- GB
- United Kingdom
- Prior art keywords
- salts
- riboflavin
- phosphate
- manufacture
- fractional crystallization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- FVTCRASFADXXNN-SCRDCRAPSA-N flavin mononucleotide Chemical class OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-SCRDCRAPSA-N 0.000 title 1
- 229950001574 riboflavin phosphate Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 4
- 229910019142 PO4 Inorganic materials 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- -1 riboflavin phosphates Chemical class 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- 238000001640 fractional crystallisation Methods 0.000 abstract 2
- 239000010452 phosphate Substances 0.000 abstract 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 abstract 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 abstract 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 abstract 1
- 150000002169 ethanolamines Chemical class 0.000 abstract 1
- 235000021317 phosphate Nutrition 0.000 abstract 1
- 235000019192 riboflavin Nutrition 0.000 abstract 1
- 229960002477 riboflavin Drugs 0.000 abstract 1
- 239000002151 riboflavin Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65618—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system, e.g. flavins or analogues
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises morpholine and ethanolamine salts of riboflavin-51-phosphate and their production from aqueous mixtures of isomeric riboflavin phosphates by reacting said mixtures with morpholine or diethanolamine and separating the resulting corresponding amine salt of riboflavin-51-phosphate from the corresponding amine-salts of its isomers by fractional crystallization. The pH of the mixture of amine salts obtained as a result of the reaction is adjusted between 4 and 10, and fractional crystallization effected by adding a water-miscible solvent, e.g. ethanol, acetone or isopropanol.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US687556XA | 1950-11-08 | 1950-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB687556A true GB687556A (en) | 1953-02-18 |
Family
ID=22084512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB21143/51A Expired GB687556A (en) | 1950-11-08 | 1951-09-07 | Salts of riboflavin phosphate and the manufacture thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB687556A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4987229A (en) * | 1988-03-31 | 1991-01-22 | Basf Aktiengesellschaft | Purification of salts of riboflavin 5'-phosphate, in particular of monosodium riboflavin 5'-phosphate |
-
1951
- 1951-09-07 GB GB21143/51A patent/GB687556A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4987229A (en) * | 1988-03-31 | 1991-01-22 | Basf Aktiengesellschaft | Purification of salts of riboflavin 5'-phosphate, in particular of monosodium riboflavin 5'-phosphate |
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