GB683409A - Salts of penicillin with antihistamine organic bases - Google Patents

Salts of penicillin with antihistamine organic bases

Info

Publication number
GB683409A
GB683409A GB317150A GB317150A GB683409A GB 683409 A GB683409 A GB 683409A GB 317150 A GB317150 A GB 317150A GB 317150 A GB317150 A GB 317150A GB 683409 A GB683409 A GB 683409A
Authority
GB
United Kingdom
Prior art keywords
penicillin
salts
phenyl
salt
penicillins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB317150A
Inventor
Wallace Frank Short
Charles Isaac Brodrick
Margaret Lorimer Donaldson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boots Pure Drug Co Ltd
Original Assignee
Boots Pure Drug Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Pure Drug Co Ltd filed Critical Boots Pure Drug Co Ltd
Priority to GB317150A priority Critical patent/GB683409A/en
Publication of GB683409A publication Critical patent/GB683409A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Abstract

A salt of penicillin with an organic base possessing antihistamine activity is prepared by reacting the penicillin and the said base in an organic solvent or mixture of solvents. Alternatively, a soluble salt of penicillin and a soluble salt of the said base may be used. According to one example an aqueous solution of potassium penicillin G is brought to a pH2 by the addition of phosphoric acid, the penicillin extracted with ether and the ether extract dried over magnesium sulphate. The extract is added to a solution of 2-(N-phenyl-N-benzylaminomethyl) - 4 : 5 - dihydroglyoxaline in a mixture of ether and chloroform, allowed to stand at 0 DEG C. and the precipitated salt filtered off. Other specified salts of penicillin G are those of a -(N-phenyl-N-benzylamino) acetamidine, N - (2 - dimethylaminopropyl) phenothiazine, 2 - (N - p - methoxybenzyl-N-beta - dimethylaminoethyl) aminopyrimidine, 2 - (N - p - methoxybenzyl - N - beta dimethylaminoethyl) aminopyridine and dl-1-(41-chlorobenzhydryl) - 4 - methylpiperazine. The salts may be formed with solvent of crystallization e.g. chloroform and acetone of crystallization. Penicillins other than penicillin G are included, e.g. penicillin X and K.ALSO:Penicillin preparations for parenteral administration comprise a suspension in an oily medium e.g. arachis oil, of a penicillin salt of an organic base having antihistamine activity (see Group IV (b)), with or without the further addition of aluminium monostearate. Specified salts of penicillin G are those of a -(N-phenyl-N-benzylamino) acetamidine, N-(2-dimethylaminopropyl) phenothiazine, 2(N-p-methoxybenzyl-N-beta-dimethylaminoethyl)- -aminopyrimidine or -aminopyridine, 2-(N-phenyl-W-benzylaminomethyl)-4:5 dihydroglyoxaline, and a l-l-41 chlorobenzhydryl)4-methylpiperazine. Penicillins other than penicillin G e.g. penicillins X and K may also be used. The salts may have solvent of crystallisation e.g. chloroform and acetone of crystallisation. Preparations for oral administration may be formulated.
GB317150A 1950-02-07 1950-02-07 Salts of penicillin with antihistamine organic bases Expired GB683409A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB317150A GB683409A (en) 1950-02-07 1950-02-07 Salts of penicillin with antihistamine organic bases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB317150A GB683409A (en) 1950-02-07 1950-02-07 Salts of penicillin with antihistamine organic bases

Publications (1)

Publication Number Publication Date
GB683409A true GB683409A (en) 1952-11-26

Family

ID=9753271

Family Applications (1)

Application Number Title Priority Date Filing Date
GB317150A Expired GB683409A (en) 1950-02-07 1950-02-07 Salts of penicillin with antihistamine organic bases

Country Status (1)

Country Link
GB (1) GB683409A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE940830C (en) * 1953-12-25 1956-03-29 Josef Dr Vonkennel Process for the preparation of penicillin salts

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE940830C (en) * 1953-12-25 1956-03-29 Josef Dr Vonkennel Process for the preparation of penicillin salts

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