GB682691A - Manufacture of therapeutically active salts of camphor sulphonic acids - Google Patents

Abstract

Salts of non-halogenated comphorsulphonic acids (active and racemic) with 1-phenyl and 1-monohydroxyphenyl-2-aminoethanols and N-alkyl derivatives thereof (l- and dl-forms) are prepared by (1) reacting the base with the acid, (2) reacting a salt of the base with a salt of the acid, or (3) reacting the corresponding aryl aminomethyl ketone with the camphorsulphonic acid and reducing the product to the aminoethanol salt. In method (3), reduction is carried out by catalytic hydrogenation in aqueous solution at ordinary temperatures using palladium or nickel. The salt of the ketone may be made by direct neutralization or double decomposition. Examples show the reaction (1) l-l-(m-hydroxyphenyl)-2-methylamino-ethanol with d-camphor-b -sulphonic acid, (2) the same base with dl-camphor-a -sulphonic acid and (3) dl-l-(p-hydroxyphenyl)-2-aminoethanol hydrochloride with sodium dl-camphor-b -sulphonate. A further example describes the preparation of phenyl aminomethyl camphor-p -sulphonate and hydrogenation of the product. The Specification as open to inspection under Sect. 91 referes in general to the preparation of camphorsulphonates of aromatic ethanolamines and ethanolalkylamines, and to therapeutic compositions containing such salts. This subject-matter does not appear in the Specification as accepted.