GB656228A - The manufacture of analgesics from pyridazone and pyridazine derivatives - Google Patents
The manufacture of analgesics from pyridazone and pyridazine derivativesInfo
- Publication number
- GB656228A GB656228A GB3348248A GB3348248A GB656228A GB 656228 A GB656228 A GB 656228A GB 3348248 A GB3348248 A GB 3348248A GB 3348248 A GB3348248 A GB 3348248A GB 656228 A GB656228 A GB 656228A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyridazone
- methyl
- pyridyl
- amino
- pyridazones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Amino- and substituted amino-pyridazines and pyridazones having other hydrocarbon substituents are obtained by treating the corresponding 3-halogen-pyridazines, and 4- or 5-halogen-pyridazones with ammonia or substituted amines. In examples, 3-dimethylamino - 6 - phenylpyridazine, 4-mononomethylamino and 4 - diethylamino - 2 - phenyl - 6 - methyl - 3 - pyridazone, 4 - amino - 2 - m - tolyl - 6 - methyl - 3 - pyridazone, 4 - amino and 4 - dimethylamino-2 : 21 - pyridyl - 6 - methyl - 3 - pyridazone, and 5-amino - 2 : 6 - dimethyl - 3 - pyridazones are obtained by treating the corresponding chloro-compounds with ammonia or the corresponding amine in alcoholic solution. In the pyridazines the 6-position may be aryl and the remaining 4- and 5-positions may be methyl and in the pyridazones the 4- and 5- or 4- and 6-positions may be methyl. The products are analgesic. 5-Chloro-2 : 6-dimethyl pyridazone is obtained by chlorinating 2 : 6 - dimethyl - 3 - pyridazone. The 4 : 5-dichloro-compound is also formed. 2-m-Tolyl- and pyridyl-6-methyl-3-pyridazinones are obtained by heating levulinic acid m-tolyl hydrazone, and the corresponding mixture of the acid with 2-pyridyl-hydrazine. 4 - Chloro - 2 - m - tolyl - 6 - methyl - 3 - pyridazone is obtained by the action of phosphorus pentachloride/phosphoryl chloride mixture on the above. 4 - Chloro - 2 : 21 - pyridyl - 6 - methyl - 3 - pyridazone is obtained by the action of phosphorus pentachloride/phosphoryl chloride on the pyridyl derivative of the corresponding pyridazinone. Specifications 600,532 and 631,755 are referred to.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3348248A GB656228A (en) | 1948-12-30 | 1948-12-30 | The manufacture of analgesics from pyridazone and pyridazine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3348248A GB656228A (en) | 1948-12-30 | 1948-12-30 | The manufacture of analgesics from pyridazone and pyridazine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB656228A true GB656228A (en) | 1951-08-15 |
Family
ID=10353533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3348248A Expired GB656228A (en) | 1948-12-30 | 1948-12-30 | The manufacture of analgesics from pyridazone and pyridazine derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB656228A (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE950287C (en) * | 1952-06-20 | 1956-10-04 | Ciba Geigy | Process for the preparation of 6-halo-2-aryl-3-oxo-2, 3-dihydro-pyridazines |
DE953800C (en) * | 1952-06-20 | 1956-12-06 | Ciba Geigy | Process for the production of new pyridazones |
DE1000822B (en) * | 1954-04-02 | 1957-01-17 | Hoffmann La Roche | Process for the preparation of pyridazone compounds |
DE959095C (en) * | 1955-05-07 | 1957-02-28 | Basf Ag | Process for the preparation of pyridazone derivatives |
DE1008738B (en) * | 1954-01-20 | 1957-05-23 | Ciba Geigy | Process for the preparation of new pyridazone (3) compounds |
US2798869A (en) * | 1952-06-20 | 1957-07-09 | Ciba Pharm Prod Inc | Pyridazones and process for manufacture thereof |
US2824873A (en) * | 1958-02-25 | Production of pyridazone derivatives | ||
US3012032A (en) * | 1958-05-07 | 1961-12-05 | Norwich Pharma Co | 2-[2-(4-pyridyl)-ethyl]-6-methyl-4, 5-dihydro-3-pyridazinone |
DE1166786B (en) * | 1959-08-05 | 1964-04-02 | Ciba Geigy | Process for the preparation of 2,3-diazaphenthiazine derivatives |
JP2007510689A (en) * | 2003-11-10 | 2007-04-26 | ラボラトリオス・アルミラル・ソシエダッド・アノニマ | Novel pyridazine-3 (2H) -one derivatives |
-
1948
- 1948-12-30 GB GB3348248A patent/GB656228A/en not_active Expired
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2824873A (en) * | 1958-02-25 | Production of pyridazone derivatives | ||
DE950287C (en) * | 1952-06-20 | 1956-10-04 | Ciba Geigy | Process for the preparation of 6-halo-2-aryl-3-oxo-2, 3-dihydro-pyridazines |
DE953800C (en) * | 1952-06-20 | 1956-12-06 | Ciba Geigy | Process for the production of new pyridazones |
US2798869A (en) * | 1952-06-20 | 1957-07-09 | Ciba Pharm Prod Inc | Pyridazones and process for manufacture thereof |
DE1008738B (en) * | 1954-01-20 | 1957-05-23 | Ciba Geigy | Process for the preparation of new pyridazone (3) compounds |
DE1000822B (en) * | 1954-04-02 | 1957-01-17 | Hoffmann La Roche | Process for the preparation of pyridazone compounds |
DE1000822C2 (en) * | 1954-04-02 | 1957-06-27 | Hoffmann La Roche | Process for the preparation of pyridazone compounds |
DE959095C (en) * | 1955-05-07 | 1957-02-28 | Basf Ag | Process for the preparation of pyridazone derivatives |
US3012032A (en) * | 1958-05-07 | 1961-12-05 | Norwich Pharma Co | 2-[2-(4-pyridyl)-ethyl]-6-methyl-4, 5-dihydro-3-pyridazinone |
DE1166786B (en) * | 1959-08-05 | 1964-04-02 | Ciba Geigy | Process for the preparation of 2,3-diazaphenthiazine derivatives |
JP2007510689A (en) * | 2003-11-10 | 2007-04-26 | ラボラトリオス・アルミラル・ソシエダッド・アノニマ | Novel pyridazine-3 (2H) -one derivatives |
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