GB621231A - The manufacture of tertiary carbinols - Google Patents

The manufacture of tertiary carbinols

Info

Publication number
GB621231A
GB621231A GB159047A GB159047A GB621231A GB 621231 A GB621231 A GB 621231A GB 159047 A GB159047 A GB 159047A GB 159047 A GB159047 A GB 159047A GB 621231 A GB621231 A GB 621231A
Authority
GB
United Kingdom
Prior art keywords
phenyl magnesium
ester
hydrochloride
manufacture
magnesium halide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB159047A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Products Ltd
Original Assignee
Roche Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Products Ltd filed Critical Roche Products Ltd
Priority to GB159047A priority Critical patent/GB621231A/en
Publication of GB621231A publication Critical patent/GB621231A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Abstract

Tertiary carbinols of the general formula: <FORM:0621231/IV (b)/1> in which R, together with R2, represent a heterocyclic ring which includes the nitrogen atom, and R3 is alkyl, are prepared by the reaction in an inert solvent of a phenyl magnesium halide with an ester of the formula: <FORM:0621231/IV (b)/2> in which R is, e.g. an ethyl group. It is preferred to use a salt of the amino-ester, in which case a small amount in excess of three molecular proportions of phenyl magnesium halide is necessary. In the example: 3-(diphenyl-hydroxymethyl)-1-methyl piperidine is prepared via the hydrochloride from N-methyl-hexahydronicotinic acid ethyl ester hydrochloride in bezene and phenyl magnesium bromide in ether. Specification 615,136 is referred to.
GB159047A 1947-01-17 1947-01-17 The manufacture of tertiary carbinols Expired GB621231A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB159047A GB621231A (en) 1947-01-17 1947-01-17 The manufacture of tertiary carbinols

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB159047A GB621231A (en) 1947-01-17 1947-01-17 The manufacture of tertiary carbinols

Publications (1)

Publication Number Publication Date
GB621231A true GB621231A (en) 1949-04-06

Family

ID=9724572

Family Applications (1)

Application Number Title Priority Date Filing Date
GB159047A Expired GB621231A (en) 1947-01-17 1947-01-17 The manufacture of tertiary carbinols

Country Status (1)

Country Link
GB (1) GB621231A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2833775A (en) * 1951-08-17 1958-05-06 Schering Corp Substituted piperidines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2833775A (en) * 1951-08-17 1958-05-06 Schering Corp Substituted piperidines

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