GB614990A - A method of producing a derivative of the blood-sugar decreasing hormone, and the insulin derivative thereby produced - Google Patents

A method of producing a derivative of the blood-sugar decreasing hormone, and the insulin derivative thereby produced

Info

Publication number
GB614990A
GB614990A GB22577/46A GB2257746A GB614990A GB 614990 A GB614990 A GB 614990A GB 22577/46 A GB22577/46 A GB 22577/46A GB 2257746 A GB2257746 A GB 2257746A GB 614990 A GB614990 A GB 614990A
Authority
GB
United Kingdom
Prior art keywords
blood
reaction
hormone
sugar decreasing
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB22577/46A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Terapeutisk Laboratorium AS
Original Assignee
Novo Terapeutisk Laboratorium AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Terapeutisk Laboratorium AS filed Critical Novo Terapeutisk Laboratorium AS
Publication of GB614990A publication Critical patent/GB614990A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A derivative of the blood-sugar decreasing hormone is obtained by treating it with reagents, which similarly to isocyanates, will attack amino-groups in such a manner that a hydrogen atom, or hydrogen atoms in these groups are substituted, care being taken in the choice of the usual reaction conditions such as time, temperature and concentration of the components employed in the reaction, that the reaction proceeds only to a point at which the hormone maintains its entire, or an essential part, of its blood-sugar decreasing effect, but of altered character so that the effect in the diabetic organism is extended over a longer period of time. Preferably, the reaction is carried out in a homogeneous system, e.g. acetone-water mixture. The final point of the reaction is found by biological experiments to occur at 1-30 X 10-3 m Mol. titratable amino groups per m Mol. total-N in the blood-sugar decreasing hormone and may also be determined titrimetrically. Examples illustrate the use of benzoyl chloride, the benzyl ester of chloroformic acid and acetic anhydride as reagents which attack amino groups whilst additional reagents specified are acyl chlorides, acyl anhydrides, ketenes, alkyl halogens, aldehydes and ketones and xanthydrol. Specification 604,327 is referred to.
GB22577/46A 1943-12-13 1946-07-29 A method of producing a derivative of the blood-sugar decreasing hormone, and the insulin derivative thereby produced Expired GB614990A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK321643 1943-12-13

Publications (1)

Publication Number Publication Date
GB614990A true GB614990A (en) 1948-12-30

Family

ID=38662821

Family Applications (1)

Application Number Title Priority Date Filing Date
GB22577/46A Expired GB614990A (en) 1943-12-13 1946-07-29 A method of producing a derivative of the blood-sugar decreasing hormone, and the insulin derivative thereby produced

Country Status (3)

Country Link
ES (1) ES174955A1 (en)
FR (1) FR933190A (en)
GB (1) GB614990A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3481917A (en) * 1967-03-06 1969-12-02 American Home Prod N - mercaptosuccinoylinsulin and n - (lower)alkanoylmercaptosuccinoylinsulin
US3509120A (en) * 1966-12-28 1970-04-28 Squibb & Sons Inc N-terminal mono- and diaminoacyl-insulin
US3528960A (en) * 1968-10-07 1970-09-15 Lilly Co Eli N-carboxyaroyl insulins

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3509120A (en) * 1966-12-28 1970-04-28 Squibb & Sons Inc N-terminal mono- and diaminoacyl-insulin
US3481917A (en) * 1967-03-06 1969-12-02 American Home Prod N - mercaptosuccinoylinsulin and n - (lower)alkanoylmercaptosuccinoylinsulin
US3528960A (en) * 1968-10-07 1970-09-15 Lilly Co Eli N-carboxyaroyl insulins

Also Published As

Publication number Publication date
ES174955A1 (en) 1946-11-01
FR933190A (en) 1948-04-13

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