GB606187A - Improvements in or relating to substituted diamines - Google Patents

Improvements in or relating to substituted diamines

Info

Publication number
GB606187A
GB606187A GB20194/45A GB2019445A GB606187A GB 606187 A GB606187 A GB 606187A GB 20194/45 A GB20194/45 A GB 20194/45A GB 2019445 A GB2019445 A GB 2019445A GB 606187 A GB606187 A GB 606187A
Authority
GB
United Kingdom
Prior art keywords
aminopyridine
dimethylaminoethyl
condensing
sodamide
sulphuric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20194/45A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc SA filed Critical Rhone Poulenc SA
Publication of GB606187A publication Critical patent/GB606187A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

N - b 1 - Dimethylaminoethyl - N - p - methoxy - benzyl-a -aminopyridine, which has powerful anti-histaminic properties, is manufactured by (a) condensing a -p-methoxybenzylaminopyridine, or its sodio derivative, with a tertiary amine of the formula <FORM:0606187/IV(b)/1> (wherein X represents a halogen atom, e.g. chlorine, a hydroxy group or a sulphuric or sulphonic acid ester radical); or (b) condensing N-b 1-dimethylaminoethyl-a -aminopyridine, or its sodio derivative, with a p-methoxybenzyl halide (e.g. chloride) or alcohol, or with sulphuric or sulphonic esters of the alcohol. An example of each of these processes is given. Specification 606,181 is referred to. N-b 1-Dimethylaminoethyl-a -aminopyridine is obtainable by condensing a -aminopyridine with 1-dimethylamino-2-chloroethane in the presence of sodamide, and is converted into its sodio derivative by the action of sodamide in xylene. The Specification as open to inspection under Sect. 91 comprises also the manufacture of N-b 1-dimethylaminoethyl-N-p-methoxybenzyl-a -aminopyridine by condensing an a -halogenopyridine with N : N - dimethyl-N1-p-methoxybenzylethylenediamine, and by the use of appropriate starting materials in the alternative methods described in Specification 606,181, as open to inspection. This subject-matter does not appear in the Specification as accepted.
GB20194/45A 1943-09-09 1945-05-17 Improvements in or relating to substituted diamines Expired GB606187A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR606187X 1943-09-09

Publications (1)

Publication Number Publication Date
GB606187A true GB606187A (en) 1948-08-10

Family

ID=8974508

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20194/45A Expired GB606187A (en) 1943-09-09 1945-05-17 Improvements in or relating to substituted diamines

Country Status (1)

Country Link
GB (1) GB606187A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2785172A (en) * 1953-06-17 1957-03-12 Searle & Co Dialkylaminoalkylphenetidinopyridine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2785172A (en) * 1953-06-17 1957-03-12 Searle & Co Dialkylaminoalkylphenetidinopyridine

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