GB533354A - Process for the manufacture of new organic antimony compounds - Google Patents
Process for the manufacture of new organic antimony compoundsInfo
- Publication number
- GB533354A GB533354A GB1408739A GB1408739A GB533354A GB 533354 A GB533354 A GB 533354A GB 1408739 A GB1408739 A GB 1408739A GB 1408739 A GB1408739 A GB 1408739A GB 533354 A GB533354 A GB 533354A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methylglucamine
- antimony
- solution
- polyhydroxyamine
- antimoniate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940058905 antimony compound for treatment of leishmaniasis and trypanosomiasis Drugs 0.000 title abstract 4
- 150000001463 antimony compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 4
- 239000000243 solution Substances 0.000 abstract 4
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 abstract 3
- AQTIRDJOWSATJB-UHFFFAOYSA-K antimonic acid Chemical compound O[Sb](O)(O)=O AQTIRDJOWSATJB-UHFFFAOYSA-K 0.000 abstract 3
- VMPVEPPRYRXYNP-UHFFFAOYSA-I antimony(5+);pentachloride Chemical compound Cl[Sb](Cl)(Cl)(Cl)Cl VMPVEPPRYRXYNP-UHFFFAOYSA-I 0.000 abstract 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 230000003472 neutralizing effect Effects 0.000 abstract 2
- 230000001590 oxidative effect Effects 0.000 abstract 2
- ZGCHLAJIRWDGFE-UHFFFAOYSA-N 1-aminopropane-1,1-diol Chemical compound CCC(N)(O)O ZGCHLAJIRWDGFE-UHFFFAOYSA-N 0.000 abstract 1
- YJHWBPRELHSNOS-LJTMIZJLSA-N C(C(=O)O)(=O)O.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO Chemical compound C(C(=O)O)(=O)O.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO YJHWBPRELHSNOS-LJTMIZJLSA-N 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- FAWGZAFXDJGWBB-UHFFFAOYSA-N antimony(3+) Chemical class [Sb+3] FAWGZAFXDJGWBB-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/90—Antimony compounds
- C07F9/902—Compounds without antimony-carbon linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
533,354. Organic antimonycompounds. SOC. DES USINES CHIMIQUES RHONEPOULENC., and GAILLIOT, P. L. May 11, 1939, No. 14087. [Class 2 (iii)] Organic antimony compounds of therapeutic value are prepared by neutralizing antimonic acid with an aliphatic polyhydroxyamine in which at least two hydroxyl groups are attached to the same carbon chain. The antimonic acid may be formed during the reaction, e.g., from antimony pentachloride. The compounds may also be prepared by reacting known amineantimoniates with a salt of the polyhydroxyamine whereby the amine component is replaced by the polyhydroxyamine, or by carrying out the foregoing processes with a derivative of trivalent antimony and oxidizing the product. The antimony compounds give stable solutions in the presence of sodium chloride. According to the examples : (1) A solution of antimony pentachloride in chloroform is added to a solution of N-methylglucamine in aqueous diethylamine; the chloroform is decanted and the aqueous solution poured into alcohol to precipitate the antimoniate of methylglucamine; (2) the same product is obtained by interaction of calcium antimoniate with N-methylglucamine oxalate ; or (3) by replacing the antimony pentachloride in the process of (1) by the trichloride and oxidizing the product in solution with hydrogen peroxide; (4) galactamine and glucamine antimoniates are formed when the process of (1) is carried out with the use of galactamine or glucamine in place of N-methylglucamine ; (5) the antimoniate of aminopropanediol is prepared by neutralizing antimonic acid with the amino-alcohol.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1408739A GB533354A (en) | 1939-05-11 | 1939-05-11 | Process for the manufacture of new organic antimony compounds |
| FR868747D FR868747A (en) | 1939-05-11 | 1940-03-27 | Process for the preparation of antimony derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1408739A GB533354A (en) | 1939-05-11 | 1939-05-11 | Process for the manufacture of new organic antimony compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB533354A true GB533354A (en) | 1941-02-12 |
Family
ID=10034747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1408739A Expired GB533354A (en) | 1939-05-11 | 1939-05-11 | Process for the manufacture of new organic antimony compounds |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR868747A (en) |
| GB (1) | GB533354A (en) |
-
1939
- 1939-05-11 GB GB1408739A patent/GB533354A/en not_active Expired
-
1940
- 1940-03-27 FR FR868747D patent/FR868747A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR868747A (en) | 1942-01-14 |
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