GB506095A - Process for the preparation of inoculation material - Google Patents
Process for the preparation of inoculation materialInfo
- Publication number
- GB506095A GB506095A GB12467/38A GB1246738A GB506095A GB 506095 A GB506095 A GB 506095A GB 12467/38 A GB12467/38 A GB 12467/38A GB 1246738 A GB1246738 A GB 1246738A GB 506095 A GB506095 A GB 506095A
- Authority
- GB
- United Kingdom
- Prior art keywords
- killed
- culture
- benzene
- solution
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000011081 inoculation Methods 0.000 title abstract 2
- 239000000463 material Substances 0.000 title abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 9
- QGJOPFRUJISHPQ-UHFFFAOYSA-N Carbon disulfide Chemical compound S=C=S QGJOPFRUJISHPQ-UHFFFAOYSA-N 0.000 abstract 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 4
- LELOWRISYMNNSU-UHFFFAOYSA-N hydrogen cyanide Chemical compound N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 abstract 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- 241000304886 Bacilli Species 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 2
- 230000008014 freezing Effects 0.000 abstract 2
- 238000007710 freezing Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000004006 olive oil Substances 0.000 abstract 2
- 235000008390 olive oil Nutrition 0.000 abstract 2
- 239000002574 poison Substances 0.000 abstract 2
- 231100000614 poison Toxicity 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 210000002268 wool Anatomy 0.000 abstract 2
- 241000700199 Cavia porcellus Species 0.000 abstract 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 abstract 1
- 241000712469 Fowl plague virus Species 0.000 abstract 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000005662 Paraffin oil Substances 0.000 abstract 1
- 241000295644 Staphylococcaceae Species 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 239000001569 carbon dioxide Substances 0.000 abstract 1
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 150000008282 halocarbons Chemical class 0.000 abstract 1
- 238000007654 immersion Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 abstract 1
- 229910052753 mercury Inorganic materials 0.000 abstract 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 235000019198 oils Nutrition 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 239000012266 salt solution Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 239000008096 xylene Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
- A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
506,095. Vaccines and the like. CHEMICAL WORKS. April 26, 1938, No. 12467. Convention date, May 8, 1937. [Class 81 (i)] Material for inoculation purposes is prepared by freeing cultures of bacteria &c. from water by exposure to a high vacuum at temperatures below 0 C. and killing the bacteria &c. in the dry state by treatment with anhydrous cell poisons or radiations of short wave length. The cultures are frozen rapidly by immersion in a mixture of carbon dioxide and ether, or liquid air, and dried in a vacuum of less than 0À001 mm. of mercury. The dehydrated organisms are then killed by treatment with anhydrous cell poisons such as hydrocyanic acid, hydrogen sulphide, carbon disulphide or formaldehyde, or by ultra violet light, the process being carried out preferably in a solvent, for example benzene, xylene, halogenated hydrocarbons or ether. The product after being freed from solvent may be taken up in physiological salt solution or in a non-aqueous oil or fat, e.g. paraffin oil, olive oil, wool fat. Example 1. Staphylococci after freezing and drying are killed by a solution of hydrocyanic acid in benzene. The dry product is suspended in a mixture of anhydrous wool fat and olive oil. Example 2. Streptococci, after separation from a culture, freezing and drying, are killed by means of a solution of formaldehyde in benzene. The product is dispersed in physiological salt. solution containing a trace of pyridine. Example 3. Dehydrated tubercle bacilli are killed by extraction with carbon disulphide. Example 4. A culture of tubercle bacilli obtained by culture in a collodion sac inserted in the abdonimal cavity of a guinea pig is treated according to the method of example 2. Example 5. The brain of a fowl infected with fowl plague virus is rubbed to a paste and treated according to examples 1-3.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH506095X | 1937-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB506095A true GB506095A (en) | 1939-05-23 |
Family
ID=4517157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB12467/38A Expired GB506095A (en) | 1937-05-08 | 1938-04-26 | Process for the preparation of inoculation material |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB506095A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2598659A (en) * | 1949-04-20 | 1952-06-03 | American Cyanamid Co | Preparation of diagnostic antigens |
| US2798835A (en) * | 1954-01-18 | 1957-07-09 | American Cyanamid Co | Newcastle disease and infectious bronchitis vaccines and production thereof |
| US2798836A (en) * | 1954-01-18 | 1957-07-09 | American Cyanamid Co | Inhalable live virus veterinary vaccine |
| US2981658A (en) * | 1958-07-07 | 1961-04-25 | Julius S Youngner | Lipid purification and concentration of viruses and vaccines therefrom |
| US3065141A (en) * | 1960-08-24 | 1962-11-20 | Albert E Gessler | Separation of nucleoproteins and nucleic acids from aqueous protein mixtures |
-
1938
- 1938-04-26 GB GB12467/38A patent/GB506095A/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2598659A (en) * | 1949-04-20 | 1952-06-03 | American Cyanamid Co | Preparation of diagnostic antigens |
| US2798835A (en) * | 1954-01-18 | 1957-07-09 | American Cyanamid Co | Newcastle disease and infectious bronchitis vaccines and production thereof |
| US2798836A (en) * | 1954-01-18 | 1957-07-09 | American Cyanamid Co | Inhalable live virus veterinary vaccine |
| US2981658A (en) * | 1958-07-07 | 1961-04-25 | Julius S Youngner | Lipid purification and concentration of viruses and vaccines therefrom |
| US3065141A (en) * | 1960-08-24 | 1962-11-20 | Albert E Gessler | Separation of nucleoproteins and nucleic acids from aqueous protein mixtures |
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