GB568384A - Whooping cough toxin - Google Patents
Whooping cough toxinInfo
- Publication number
- GB568384A GB568384A GB1736542A GB1736542A GB568384A GB 568384 A GB568384 A GB 568384A GB 1736542 A GB1736542 A GB 1736542A GB 1736542 A GB1736542 A GB 1736542A GB 568384 A GB568384 A GB 568384A
- Authority
- GB
- United Kingdom
- Prior art keywords
- endotoxin
- pertussis
- endotoxoid
- suspending
- suspension
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
An endotoxin specific for pertussis is obtained by suspending pertussis organisms, particularly the phase 1 organisms in a saline solution, repeatedly freezing and thawing the suspension, then drying the latter to concentrate the electrolyte and form a dried mass containing the endotoxin, and finally re-suspending the dried mass in sterile distilled water. By centrifuging the re-suspension, the endotoxin is obtained in the solution. The endotoxin may be precipitated by 2 per cent acid acid. It is stable at 4 DEG C., but a preservative such as sodium p ethylmercuri-thiosalicylate may be added. An endotoxoid may be obtained from the endotoxin by treatment with formalin, and by injecting an animal with the endotoxoid and separating from its blood a serum, the latter forms an anti-endotoxin specific to pertussis. Examples of preparation of the products and of tests carried out therewith are given. Specification 433,910 is referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1736542A GB568384A (en) | 1942-12-07 | 1942-12-07 | Whooping cough toxin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1736542A GB568384A (en) | 1942-12-07 | 1942-12-07 | Whooping cough toxin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB568384A true GB568384A (en) | 1945-04-03 |
Family
ID=10093918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1736542A Expired GB568384A (en) | 1942-12-07 | 1942-12-07 | Whooping cough toxin |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB568384A (en) |
-
1942
- 1942-12-07 GB GB1736542A patent/GB568384A/en not_active Expired
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