GB441122A - Improvements in or relating to the manufacture of hydrogenated heterocyclic nitrogencompounds - Google Patents

Improvements in or relating to the manufacture of hydrogenated heterocyclic nitrogencompounds

Info

Publication number
GB441122A
GB441122A GB1098834A GB1098834A GB441122A GB 441122 A GB441122 A GB 441122A GB 1098834 A GB1098834 A GB 1098834A GB 1098834 A GB1098834 A GB 1098834A GB 441122 A GB441122 A GB 441122A
Authority
GB
United Kingdom
Prior art keywords
acid
nickel
catalyst
quinoline
sulphonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1098834A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Priority to GB1098834A priority Critical patent/GB441122A/en
Publication of GB441122A publication Critical patent/GB441122A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)

Abstract

Carboxylic and sulphonic acids of the pyridine, quinoline and acridine series are hydrogenated by subjecting them, or their alkali metal salts, in a liquid medium to the action of hydrogen at elevated temperature and pressure in the presence of a base metal catalyst such as finely-divided nickel, cobalt, iron or copper, preferably mounted on a carrier. Temperatures of 125--250 DEG C. and pressures of 10--200 atmospheres are referred to. Examples are given of the preparation of (1) nipecotinic acid by treatment of nicotinic acid dissolved in ethyl alcohol, using as catalyst reduced nickel mounted on kieselguhr; sodium nipecotinate may be similarly prepared from sodium nicotinate; (2) potassium a -pipecolinate from potassium a -picolinate in aqueous solution with a nickel-kieselguhr catalyst. Chromium oxide is also referred to as a carrier and the catalyst may then be prepared by reducing, for example, nickel chromate. The process may also be applied to the hydrogenation of 4-methyl-pyridine-2-carboxylic acid, 2 : 5-diethylpyridine-3 - carboxylic acid and 2 - methylpyridine - 5 - sulphonic acid to the corresponding piperidine compounds; quinoline-2-carboxylic acid and quinoline-6-sulphonic acid to the decahydroquinoline compounds; and acridine-2-sulphonic acid to the tetradecahydroacridine compound.
GB1098834A 1934-04-11 1934-04-11 Improvements in or relating to the manufacture of hydrogenated heterocyclic nitrogencompounds Expired GB441122A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1098834A GB441122A (en) 1934-04-11 1934-04-11 Improvements in or relating to the manufacture of hydrogenated heterocyclic nitrogencompounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1098834A GB441122A (en) 1934-04-11 1934-04-11 Improvements in or relating to the manufacture of hydrogenated heterocyclic nitrogencompounds

Publications (1)

Publication Number Publication Date
GB441122A true GB441122A (en) 1936-01-09

Family

ID=9977978

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1098834A Expired GB441122A (en) 1934-04-11 1934-04-11 Improvements in or relating to the manufacture of hydrogenated heterocyclic nitrogencompounds

Country Status (1)

Country Link
GB (1) GB441122A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2657211A (en) * 1951-09-12 1953-10-27 Sterling Drug Inc Preparation of 1-methylpiperidylmethanols

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2657211A (en) * 1951-09-12 1953-10-27 Sterling Drug Inc Preparation of 1-methylpiperidylmethanols

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