GB361493A - - Google Patents
Info
- Publication number
- GB361493A GB361493A GB28717/30A GB2871730A GB361493A GB 361493 A GB361493 A GB 361493A GB 28717/30 A GB28717/30 A GB 28717/30A GB 2871730 A GB2871730 A GB 2871730A GB 361493 A GB361493 A GB 361493A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dimethylamino
- diethylamino
- propanol
- dimethyl
- chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The p-nitrobenzoic acid esters of 3-dimethylamino-2-dimethylpropanol-1, 3-diethylamino-2-dimethylpropanol-1 and 3-dimethylamino-2-isopropylpropanol-1 are reduced to the corresponding p-aminobenzoic acid esters by treatment with hydrogen under pressure in the presence of palladium chloride. Reference has been directed by the Comptroller to Specification 17162/05, [Class 2, Acids and salts, Organic &c.].ALSO:Alkamine esters are prepared by esterifying amino-alcohols of the formula-- <FORM:0361493/IV/1> (in which R represents alkyl and R<1> signifies alkyl or hydrogen) with benzoic acid or its nitro derivatives, followed if desired by reduction of the nitro group. The products possess therapeutic properties. The examples describe the preparation of esters from (1) benzoyl chloride and 3-dimethylamino-2-dimethyl-propanol-1; (2) p-nitrobenzoyl chloride and 3 - dimethylamino-2-dimethylpropanol-1, followed by catalytic reduction under pressure in the presence of palladium chloride; (3) benzoyl chloride and 3-diethylamino-2-dimethylpropanol-1; (4) p-nitrobenzoyl chloride and 3-diethylamino-2-dimethyl-propanol-1, followed by reduction with hydrogen under pressure using palladium chloride as catalyst; (5) p-nitrobenzoyl chloride and 3-dimethylamino-2-isopropyl-propanol-1, with subsequent catalytic reduction to the amino compound; (6) benzoic acid and 3-dimethylamino-2-dimethyl-propanol-1. Amino-alcohols.--The amino-alcohols employed in the foregoing process are prepared by condensing aldehydes of the formula <FORM:0361493/IV/2> with formaldehyde and secondary amines <FORM:0361493/IV/3> , and reducing the resulting aldehyde-amines. An example is given of the preparation of 3-diethylamino-2-dimethyl-propanol-1 by interaction of isobutylaldehyde, diethylamine and paraformaldehyde and subsequent reduction of the 3-diethylamino-2-dimethyl-propionaldehyde with the aid of sodium amalgam. Specification 17162/05 is referred to. Reference has been directed by the Comptroller to Specification 17162/05, [Class 2, Acids and salts, Organic &c.].
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE361493T | 1929-11-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB361493A true GB361493A (en) | 1931-11-26 |
Family
ID=31895443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB28717/30A Expired GB361493A (en) | 1929-11-01 | 1930-09-25 |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB361493A (en) |
-
1930
- 1930-09-25 GB GB28717/30A patent/GB361493A/en not_active Expired
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