GB293152A - Improvements in and relating to the manufacture of organo arsenic compounds - Google Patents
Improvements in and relating to the manufacture of organo arsenic compoundsInfo
- Publication number
- GB293152A GB293152A GB1186427A GB1186427A GB293152A GB 293152 A GB293152 A GB 293152A GB 1186427 A GB1186427 A GB 1186427A GB 1186427 A GB1186427 A GB 1186427A GB 293152 A GB293152 A GB 293152A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- amino
- cyanogen
- acids
- arsinic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 organo arsenic compounds Chemical class 0.000 title abstract 6
- 229940093920 gynecological arsenic compound Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 4
- 150000008064 anhydrides Chemical class 0.000 abstract 3
- 150000007513 acids Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 abstract 2
- JMANVNJQNLATNU-UHFFFAOYSA-N glycolonitrile Natural products N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- RPAJSBKBKSSMLJ-DFWYDOINSA-N (2s)-2-aminopentanedioic acid;hydrochloride Chemical class Cl.OC(=O)[C@@H](N)CCC(O)=O RPAJSBKBKSSMLJ-DFWYDOINSA-N 0.000 abstract 1
- RNXVXXXZBIXZMS-UHFFFAOYSA-N (4-aminophenyl)arsinic acid Chemical compound NC1=CC=C([AsH](O)=O)C=C1 RNXVXXXZBIXZMS-UHFFFAOYSA-N 0.000 abstract 1
- UUZXLWWVWFQSFK-UHFFFAOYSA-N NC=1C=C(C=CC=1C(=O)O)[AsH](O)=O Chemical compound NC=1C=C(C=CC=1C(=O)O)[AsH](O)=O UUZXLWWVWFQSFK-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- WCZVZNOTHYJIEI-UHFFFAOYSA-N cinnoline Chemical compound N1=NC=CC2=CC=CC=C21 WCZVZNOTHYJIEI-UHFFFAOYSA-N 0.000 abstract 1
- QPJDMGCKMHUXFD-UHFFFAOYSA-N cyanogen chloride Chemical compound ClC#N QPJDMGCKMHUXFD-UHFFFAOYSA-N 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/66—Arsenic compounds
- C07F9/70—Organo-arsenic compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
293,152. Stickings, R. W. E., and May & Baker, Ltd. May 3, 1927. Carbamido-arylarsinic acids and their inner anhydrides are prepared by condensing amino-arylarsinic acids and their substitution products with a cyanogen halide in an aqueous medium. The cyanogen halide combines with the amine group and the product becomes hydrolyzed to the carbamido compound. When a substituent capable of condensing with the urea residue is present in the o-position thereto, heterocyclic arsinic acids result; if the substituent is a hydroxy group benzoxazoles are formed, if an amino group benzimidazoles result, and if a carboxyl group the compound formed is a benzdiazine. The products possess therapeutic properties. According to the examples, (1) the sodium salt of p-aminophenylarsinic acid is condensed with an aqueous suspension of cyanogen bromide, to form phenylurea-parsinic acid, (2) 3-amino-4-hvdroxyphenylarsinic acid and cyanogen bromide yield the inner anhydride of 2-hydroxyphenylurea-5-arsinic acid, (3) 3-amino-4-carboxyphenylarsinic acid condensed with cyanogen chloride gives the inner anhydride of 2-carboxyphenylurea-5-arsinic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1186427A GB293152A (en) | 1927-05-03 | 1927-05-03 | Improvements in and relating to the manufacture of organo arsenic compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1186427A GB293152A (en) | 1927-05-03 | 1927-05-03 | Improvements in and relating to the manufacture of organo arsenic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB293152A true GB293152A (en) | 1928-07-05 |
Family
ID=9994077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1186427A Expired GB293152A (en) | 1927-05-03 | 1927-05-03 | Improvements in and relating to the manufacture of organo arsenic compounds |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB293152A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2559061A (en) * | 1946-07-15 | 1951-07-03 | Parke Davis & Co | Phenylcyanamides and methods for obtaining the same |
| US2981745A (en) * | 1960-01-25 | 1961-04-25 | Whitmoyer Lab Inc | Manufacture of p-ureidobenzenearsonic acid |
-
1927
- 1927-05-03 GB GB1186427A patent/GB293152A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2559061A (en) * | 1946-07-15 | 1951-07-03 | Parke Davis & Co | Phenylcyanamides and methods for obtaining the same |
| US2981745A (en) * | 1960-01-25 | 1961-04-25 | Whitmoyer Lab Inc | Manufacture of p-ureidobenzenearsonic acid |
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