GB255971A - Process for making arsonophenyl amino alcohols - Google Patents
Process for making arsonophenyl amino alcoholsInfo
- Publication number
- GB255971A GB255971A GB11795/25A GB1179525A GB255971A GB 255971 A GB255971 A GB 255971A GB 11795/25 A GB11795/25 A GB 11795/25A GB 1179525 A GB1179525 A GB 1179525A GB 255971 A GB255971 A GB 255971A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- acidifying
- caustic soda
- arsonophenylcarbamate
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 arsonophenyl amino Chemical group 0.000 title abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 12
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 6
- 239000002253 acid Substances 0.000 abstract 4
- 235000011121 sodium hydroxide Nutrition 0.000 abstract 4
- DMDVKUMEPVMUKN-UHFFFAOYSA-N (4-arsonophenyl)carbamic acid Chemical compound C1=CC(=CC=C1NC(=O)O)[As](=O)(O)O DMDVKUMEPVMUKN-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 239000003513 alkali Substances 0.000 abstract 2
- 229940072033 potash Drugs 0.000 abstract 2
- 235000011118 potassium hydroxide Nutrition 0.000 abstract 2
- VKZSTPIORBKEBP-UHFFFAOYSA-N (3-amino-4-methylphenyl)arsonic acid Chemical compound CC1=CC=C([As](O)(O)=O)C=C1N VKZSTPIORBKEBP-UHFFFAOYSA-N 0.000 abstract 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 229940093920 gynecological arsenic compound Drugs 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/66—Arsenic compounds
- C07F9/70—Organo-arsenic compounds
- C07F9/74—Aromatic compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
255,971. Marks, E. C. R., (Abbott Laboratories). May 6, 1925. Organo arsenic compounds.- Arsonophenylaminoalcohols are prepared by treating an arsanalic acid or substituted arsanalic acid dissolved in alkali with an #-chloralkylchlorcarbonate, decomposing the resulting #-chloralkylarsonophenylcarbamate with alkali and then acidifying. The products can be converted into salts and possess therapeutic properties. According to the examples, (1) #-chlorethylchlorcarbonate is slowly added to a caustic soda solution of o- or parsanalic acid and the precipitated #-chlorethyl-o- or p-arsonophenylcarbamate refluxed with caustic soda or potash; on cooling and acidifying, o- or parsonophenylaminoethanol separates out; (2) gammachlorpropyl-o or p-arsonophenylcarbamate is prepared by the interaction of o- or parsanalic acid with gamma-chlorpropylchlorcarbonate and decomposed with caustic soda or potash to give o- or parsonophenylaminopropanol on acidifying; (3) arsonophenyl-4-methyl-3-aminoethanol is obtained by treating 4-methyl-3-aminophenylarsonic acid with #-chlorethylchlorcarbonate, decomposing the resulting 3-#-chlorethyl-4-methyl-arsonophenylcarbamate with caustic soda and acidifying with hydrochloric acid. #-Chloralkylchlorcarbonates are obtained by condensing an alkylene chlorhydrin with phosgene.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB11795/25A GB255971A (en) | 1925-05-06 | 1925-05-06 | Process for making arsonophenyl amino alcohols |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB11795/25A GB255971A (en) | 1925-05-06 | 1925-05-06 | Process for making arsonophenyl amino alcohols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB255971A true GB255971A (en) | 1926-08-05 |
Family
ID=9992836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB11795/25A Expired GB255971A (en) | 1925-05-06 | 1925-05-06 | Process for making arsonophenyl amino alcohols |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB255971A (en) |
-
1925
- 1925-05-06 GB GB11795/25A patent/GB255971A/en not_active Expired
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