GB2528632A - Fluidic analysis and separation - Google Patents

Fluidic analysis and separation Download PDF

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Publication number
GB2528632A
GB2528632A GB1407641.8A GB201407641A GB2528632A GB 2528632 A GB2528632 A GB 2528632A GB 201407641 A GB201407641 A GB 201407641A GB 2528632 A GB2528632 A GB 2528632A
Authority
GB
United Kingdom
Prior art keywords
flow
fluid flow
component
fluid
flows
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB1407641.8A
Other languages
English (en)
Other versions
GB201407641D0 (en
Inventor
Tuomas Knowles
Thomas Mueller
Therese Herling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cambridge Enterprise Ltd
Original Assignee
Cambridge Enterprise Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Enterprise Ltd filed Critical Cambridge Enterprise Ltd
Priority to GB1407641.8A priority Critical patent/GB2528632A/en
Publication of GB201407641D0 publication Critical patent/GB201407641D0/en
Priority to US15/307,221 priority patent/US10386332B2/en
Priority to PCT/GB2015/051256 priority patent/WO2015166247A1/en
Priority to EP18153608.7A priority patent/EP3349001A1/en
Priority to JP2016565451A priority patent/JP6387112B2/ja
Priority to AU2015255073A priority patent/AU2015255073B2/en
Priority to CN201580023656.8A priority patent/CN106457243B/zh
Priority to EP15720767.1A priority patent/EP3137889B1/en
Priority to CA2946348A priority patent/CA2946348A1/en
Priority to CN201910000699.4A priority patent/CN110052296B/zh
Priority to DK15720767.1T priority patent/DK3137889T3/en
Publication of GB2528632A publication Critical patent/GB2528632A/en
Priority to JP2018148507A priority patent/JP6592151B2/ja
Priority to HK19100605.6A priority patent/HK1258244A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44756Apparatus specially adapted therefor
    • G01N27/44795Isoelectric focusing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44756Apparatus specially adapted therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44756Apparatus specially adapted therefor
    • G01N27/44769Continuous electrophoresis, i.e. the sample being continuously introduced, e.g. free flow electrophoresis [FFE]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44756Apparatus specially adapted therefor
    • G01N27/44791Microapparatus
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652Sorting or classification of particles or molecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0645Electrodes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883Serpentine channels
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
    • B01L2400/0451Thermophoresis; Thermodiffusion; Soret-effect
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0472Diffusion
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02Investigating particle size or size distribution
    • G01N15/0266Investigating particle size or size distribution with electrical classification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Electrochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Optical Measuring Cells (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
GB1407641.8A 2014-04-30 2014-04-30 Fluidic analysis and separation Withdrawn GB2528632A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
GB1407641.8A GB2528632A (en) 2014-04-30 2014-04-30 Fluidic analysis and separation
DK15720767.1T DK3137889T3 (en) 2014-04-30 2015-04-30 FLOW TECHNICAL ANALYSIS AND SEPARATION
CN201580023656.8A CN106457243B (zh) 2014-04-30 2015-04-30 流体的分析和分离
CA2946348A CA2946348A1 (en) 2014-04-30 2015-04-30 Fluidic analysis and separation
EP18153608.7A EP3349001A1 (en) 2014-04-30 2015-04-30 Fluidic analysis and separation
JP2016565451A JP6387112B2 (ja) 2014-04-30 2015-04-30 流体の分析および分離
AU2015255073A AU2015255073B2 (en) 2014-04-30 2015-04-30 Fluidic analysis and separation
US15/307,221 US10386332B2 (en) 2014-04-30 2015-04-30 Fluidic analysis and separation
EP15720767.1A EP3137889B1 (en) 2014-04-30 2015-04-30 Fluidic analysis and separation
PCT/GB2015/051256 WO2015166247A1 (en) 2014-04-30 2015-04-30 Fluidic analysis and separation
CN201910000699.4A CN110052296B (zh) 2014-04-30 2015-04-30 流体的分析和分离
JP2018148507A JP6592151B2 (ja) 2014-04-30 2018-08-07 流体の分析および分離
HK19100605.6A HK1258244A1 (en) 2014-04-30 2019-01-14 Fluidic analysis and separation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1407641.8A GB2528632A (en) 2014-04-30 2014-04-30 Fluidic analysis and separation

Publications (2)

Publication Number Publication Date
GB201407641D0 GB201407641D0 (en) 2014-06-11
GB2528632A true GB2528632A (en) 2016-02-03

Family

ID=50972140

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1407641.8A Withdrawn GB2528632A (en) 2014-04-30 2014-04-30 Fluidic analysis and separation

Country Status (10)

Country Link
US (1) US10386332B2 (enExample)
EP (2) EP3349001A1 (enExample)
JP (2) JP6387112B2 (enExample)
CN (2) CN106457243B (enExample)
AU (1) AU2015255073B2 (enExample)
CA (1) CA2946348A1 (enExample)
DK (1) DK3137889T3 (enExample)
GB (1) GB2528632A (enExample)
HK (1) HK1258244A1 (enExample)
WO (1) WO2015166247A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201219014D0 (en) 2012-10-23 2012-12-05 Cambridge Entpr Ltd Fluidic device
GB201320146D0 (en) 2013-11-14 2014-01-01 Cambridge Entpr Ltd Fluidic separation and detection
GB2528632A (en) * 2014-04-30 2016-02-03 Cambridge Entpr Ltd Fluidic analysis and separation
GB201511651D0 (en) 2015-07-02 2015-08-19 Cambridge Entpr Ltd Viscosity measurements
GB201602946D0 (en) 2016-02-19 2016-04-06 Fluidic Analytics Ltd And Cambridge Entpr Ltd Improvements in or relating to microfluidic free-flow electrophoresis
JP6980691B2 (ja) 2016-04-06 2021-12-15 フルイディック・アナリティクス・リミテッド フローバランスの改善またはそれに関連した改善
GB2553519B (en) 2016-09-02 2019-12-18 Fluidic Analytics Ltd Improvements in or relating to a fluid flow controller for microfluidic devices
GB201615452D0 (en) 2016-09-12 2016-10-26 Fluidic Analytics Ltd Improvements in or relating to valves for microfluidics devices
GB2553780A (en) 2016-09-12 2018-03-21 Fluidic Analytics Ltd Improvements in or relating to a device and a method for labelling a component
GB201615472D0 (en) 2016-09-12 2016-10-26 Fluidic Analytics Ltd Improvements in or relating to a reagent cartridge
GB201820870D0 (en) * 2018-12-20 2019-02-06 Cambridge Entpr Ltd Detection of components
GB201904376D0 (en) * 2019-03-29 2019-05-15 Fluidic Analytics Ltd Improvements in or relating to a method of separating and amalysing a component
CN111289344A (zh) * 2020-01-16 2020-06-16 西安交通大学 一种三维等电聚焦装置及方法
CN111495450B (zh) * 2020-04-24 2021-04-06 清华大学 基于柱塞-叠片混合流的液-液-液三相流微流体芯片

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WO2006037561A1 (en) * 2004-10-01 2006-04-13 Rudolf Rigler Selection of particles in laminar flow
US20080237044A1 (en) * 2007-03-28 2008-10-02 The Charles Stark Draper Laboratory, Inc. Method and apparatus for concentrating molecules

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GB201320146D0 (en) 2013-11-14 2014-01-01 Cambridge Entpr Ltd Fluidic separation and detection
GB2528632A (en) * 2014-04-30 2016-02-03 Cambridge Entpr Ltd Fluidic analysis and separation

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
WO2003066191A1 (en) * 2002-02-04 2003-08-14 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
US20050121604A1 (en) * 2003-09-04 2005-06-09 Arryx, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
WO2006037561A1 (en) * 2004-10-01 2006-04-13 Rudolf Rigler Selection of particles in laminar flow
US20080237044A1 (en) * 2007-03-28 2008-10-02 The Charles Stark Draper Laboratory, Inc. Method and apparatus for concentrating molecules

Also Published As

Publication number Publication date
HK1258244A1 (en) 2019-11-08
CN110052296A (zh) 2019-07-26
GB201407641D0 (en) 2014-06-11
EP3137889B1 (en) 2018-03-14
AU2015255073B2 (en) 2019-07-18
JP2019035746A (ja) 2019-03-07
JP2017516094A (ja) 2017-06-15
DK3137889T3 (en) 2018-04-16
CN106457243A (zh) 2017-02-22
WO2015166247A1 (en) 2015-11-05
CN106457243B (zh) 2019-01-29
CA2946348A1 (en) 2015-11-05
JP6387112B2 (ja) 2018-09-05
EP3349001A1 (en) 2018-07-18
US20170052147A1 (en) 2017-02-23
EP3137889A1 (en) 2017-03-08
US10386332B2 (en) 2019-08-20
CN110052296B (zh) 2021-04-02
JP6592151B2 (ja) 2019-10-16
AU2015255073A1 (en) 2016-10-20

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WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)