GB2516261A - Cleaning product - Google Patents

Abstract

A low allergen cleaning product comprises one or more ingredients selected from water, fermentation grade ethanol, PEG hydrogenated castor oil, cocamidopropyl betaine, PEG 12 dimethicone, dimethicone, citric acid, sodium gluconate, didecyldimonium chloride, alkyl glucoside, sodium hydroxide, sodium chloride, glycerine, isopropanol, polydimethylsiloxane, synthetic bees wax, coconut fatty acids, dodecyl benzene sulphonate, sodium citrate, alkyl polyglucoside, diethylenetriamine penta(methylene phosphonic acid), polydimethylsiloxane, dialkyl ammonium methosulphate, a low allergen fragrance compound, and a low allergen fragrance composition. Preferably, the product comprises one or more of coconut fatty acid, alkyl sulphates and alkyl polyglucosides at a concentration of less than 1.3%. The product may consist of water, fermentation grade alcohol, PEG-40 hydrogenated castor oil, cocamidopropyl betaine, dimethicone, citric acid, a low allergen fragrance, sodium gluconate and didecyldimonium chloride. Alternatively, the product may consist of water, fermentation grade alcohol, alkyl glucoside, citric acid, PEG-40 hydrogenated castor oil, a low allergen fragrance and didecyldimonium chloride. A method of making a low allergen cleaning product is also claimed.

Description

CLEANING PRODUCT

This invention relates to low-allergen cleaning product. In particular, it relates to a low allergen household cleaning product. It also relates to a method for making a low allergen cleaning product.

Asthma and allergies arc increasingly common and many asthma and allergy sufferers find that their symptoms are worsened by products that they use in their homes or workplaces. One type of product that can aggravate asthma and allergy symptoms are cleaning products. Cleaning products often contain chemicals that arc irritating to the skin, eyes or respiratory system when contacted or inhaled. Many of these chemicals have been considered necessary components of cleaning products to enable them to carry out their function of cleaning various types of dirt from surfaces. This problem is worsened because it is helpful for many asthma and allergy sufferers to keep their home or work environment clean and free from allergens in the environment such as pollen, dust or airborne pollutants. Unfortunately, the use of standard cleaning products to remove allergens from the home or work environment can introduce further allergens into the environment in the form of irritating chemicals from the cleaning products that can exacerbate allergies in the person using the cleaning product or in people nearby when it is used or coming into contact with cleaning product residues left on surfaces.

The present invention provides a range of cleaning products that only contain ingredients that have been selected to be low or non-allergenic but that also are able to perform the function of removing dirt and surface allergens.

In a first aspect the prcsent invention provides a low allergen cleaning product comprising one or more ingredients selected from: Aqua, [Solvent], Alcohol (Fermentation grade ethanol), [Solvent], PEG 40 Hydrogenate Castor Oil, [Emulsifier], Cocamidopropyl Betaine, [Surfactant], Citric Acid, [Acidifier], Sodium Gluconate, [Surfactant], Didecyldimonium Chloride [Preservative/Anti-bacterial Agent], Alkyl Glucoside, [Surfactant], Sodium Hydroxide, [Buffer], Sodium Chloride, [Salt] Glycerine, [Lubricant], Isopropanol, [Solvent], Polydimethylsiloxane, [Lubricant, Coatings], synthetic bees wax,[Wax], dodecyl benzene sulphonate, [Surfactant], sodium citrate,[Acidifier], Diethylenetriamine penta(niethylene phosphonic acid), [Chelating Agent] and dialkly ammonium methosuiphate, [Surfactant].

The low allergen cleaning product may not comprise: polydirnethylsiloxane, Natural Bees Wax, cetylstearyl alcohol, Alklyethoxylates, Dipropylene Glycol Monomethyl Ether, Disodium EDTA, Ethyl Alcohol, Diazolidinylurea, Methylchloroisothiazolinone, Methylisothiazolinone, Methylisothiazolinone, Chlorornethylisothiazolinone, Methylpropan -1 -2 -diol, Monoethanolamine or Triethanolaminc, sodium lauryl ether sulphate, sodium laurcth sulphate, alkly benzene sulphonate, alpha sulfo methyl ester, alcohol ether sulphates, lauryl sarcosinate, soap, lauryl amine oxide, nonyiphenol ethoxylates, octylphenol ethoxylates, dialkyl dimethyl diammonium chloride, alkyl dimethyl benzyl ammonium chloride, acetone, almond oil, apricot kernel oil, citronella oil, citrus oil, eucolutus oil, lavender oil, pine oil, rosemary oil, sodium hypochlorite, glutaraldehyde.

The low allergen cleaning product may not comprise: Coconut fatty acid [Surfactant] at concentrations greater than 1.3%, Alkyl Sulphates [Surfactant] at concentrations greater than 1.3% or Alkyl Polyglucosides [Surfactant] at concentrations greater than 1.3%.

The low allergen cleaning product may further comprise a low allergen fragrance composition.

The low allergen fragrance composition may comprise 1 low allergen fragrance compound, two low allergen fragrance compounds, three low allergen fragrance compounds, four low allergen fragrance compounds, five low allergen fragrance compounds, six low allergen fragrance compounds, seven low allergen fragrance compounds or eight low allergen fragrance compounds.

A low allergen fragrance compound may be any compound that provides a suitable fragrance when it is combined in a fragrance composition or in a cleaning product. A low allergen fragrance may provide a fragrance to a cleaning product that is pleasant to the user. A low allergen fragrance may provide a fragrance to a cleaning product that is relevant to that type of cleaning product or to the intended use of that cleaning product, for example a fresh fragrance may be a relevant fragrance for a cleaning product.

A low allergen fragrance compound may be a compound that does not cause or exacerbate allergic reactions, for example asthma, eczema or allergic reactions of the skin, eyes or mucosa. A low allergen fragrance compound may be a compound that does not cause sensitisation or irritation of the skin, eyes or mucosa. A low allergen fragrance compound may be a compound that does not cause sensitisation or irritation of the skin, eyes or mucosa at the concentration used in a cleaning product.

A panel of low allergen fragrance conipounds may be made by choosing fragrance compounds that do not cause sensitisation or irritation of the skin, eyes or mucosa and do not cause or exacerbate allergic reactions. Low allergen fragrance compositions may be created by selecting compounds from the panel of low allergen compounds.

Each low allergen fragrance composition may comprise or consist of two, three, four, five, six or seven low allergen fragrance compounds selected from the panel of low allergen fragrance compounds.

The combination of low allergen fragrance compounds may be selected to achieve an aesthetic and relevant fragrance effect to their designated end-use.

The fragrance composition may comprise less than 10 fragrance compounds. The fragrance composition may comprise less than fragrance compounds. The fragrance composition may comprise less than 6 fragrance compounds. The fragrance composition may comprise less than 5 fragrance compounds. The fragrance composition may comprise less than 4 fragrance compounds.

All of the fragrance compounds in the fragrance composition may be low-allergen or considered not to be allergens or sensitising to the skin, mucosa, eyes or respiratory system.

This is advantageous because fragrances commonly used in standard household cleaning products may comprise about 40 or 50 ingredients including several allergens.

The low allergen cleaning product of the present invention may comprise a low allergen fragrance composition and have a fragrance that is liked by users.

Each low allergen cleaning product may comprise a different low allergcn fragrance composition that is formulated to complement the ingredients of the cleaning product.

The low allergen fragrance composition may be made only of ingredients that are known not to cause allergies. The low allergen fragrance composition may be formulated to provide a suitable fragrance to the product depending on the intended use or the consumer's preference of fragrance for the area that the product is intended to be used. For example a bathroom cleaning product may comprise a low allergen fragrance composition designed to give a fragrance that consumers find suitable for use in a bathroom.

The low allergen cleaning product may not comprise: Amyl cinnamal, Benzyl alcohol, Cinnamyl alcohol, Citral, Eugenol, Hydroxy-citronellal, lsoeugenol, Amylcin-namyl alcohol, Benzyl salicylate, Cinnamal, Coumarin, Geraniol, Hydroxy-methylpentylcyclohexenecarboxaldehyd, Anisyl alcohol, Benzyl cinnamate, Farnesol, 2-(4-tert-Butylbenzyl) propionald-hyd, Linalool, Linalyl acetate, Styrallyl acetate Benzyl benzoate, Citronellol, Hexyl cinnam-aldehyd, d-Limonene, Methyl heptin carbonate, 3-Methyl-4-(2,6,6-tri-methyl-2-cyclohexen-1 -yl)-3-buten-2-one, Oak moss and treemoss extract or Treemoss extract.

The low allergen cleaning product may be fragrance-free. The low allergen cleaning product may not comprise any fragrance. The low allergen cleaning product may not be fragrance-free. The cleaning product may comprise a low allergen fragrance composition.

The low allergen cleaning product may be a household cleaning product.

A household cleaning product may be any product suitable for cleaning the home, but may also be used for cleaning any other environments, such as workplaces, offices, schools, hospitals or community meeting places.

The low allergen cleaning product may be a bathroom cleaner, a shower cleaner, a kitchen cleaner, a multi-surface cleaner or a window cleaner a polish, a granite and marble cleaner, a stainless steel cleaner, a hob cleaner, an oven cleaner, a mould & mildew cleaner, a bike cleaner or a ear cleaner.

A low allergen cleaning product must be suitable for cleaning the materials found in the area that it is intended for and must also be suitable for removing the type of dirt and allergens that are commonly found in the area that it is intended for. For example, a bathroom cleaner must be suitable for cleaning the type of materials that are commonly found in a bathroom such as tiles, baths and sinks. A bathroom cleaner must comprise ingredients that are suitable for removing the type of dirt and allergens that are commonly found in a bathroom such as limescale, soap scum grease and dust.

A household cleaner, for example a bathroom cleaner or a kitchen cleaner may also be anti-bacterial. A shower cleaner must be able to remove limescale and soap scum and must provide a protective layer onto the surface to help prevent additional limescale build up. A kitchen and multi-surface cleaner must be suitable for cleaning the type of surfaces that are commonly found in a kitchen and for removing the type of dirt and allergens that are commonly found in a kitchen such as grease from animal or vegetable fats, food residues dust and pollen. A kitchen multi-surface cleaner may also be anti-bacterial. A window cleaner must be able to remove dust and grease and leave a streak free shine.

The low allergen cleaning product may be suitable for removing household dirt and allergens from hard surfaces.

The low allergen cleaning product may comprise at least one solvent, at least one surfactant and at least one preservative. Thc low allergen cleaning product may further comprise a low allergen fragrance composition. The low allergen cleaning product may comprise only ingredients selected from group A and/or ingredients selected from group B at the permitted concentration. The low allergen cleaning product may not comprise any ingredients from group C or group D. The low allergen cleaning product may comprise at least one solvent selected from group A or group B, at least one surfactant selected from group A or group B and at least one preservative selected from group A or group B and the cleaning product may consist of ingredients selected from group A and/or group B at permitted levels.

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Group A -Ingredients permitted in the low allergen cleaning product Aqua, [Solvent], Alcohol (Fermentation grade ethanol), [Solvent], PEG 40 Hydrogenate Castor Oil, [Emulsifier], Cocamidopropyl Betaine,[Surfactant], Citric Acid, [Acidifier], Sodium Gluconate,[Surfaetant], Didecyldimonium Chloride [Preservative/Anti-bacterial Agent], Alkyl Glucoside, [Surfactant], Sodium Hydroxide, [Buffer], Sodium Chloride,[Salt] Glycerine, [Lubricant], Isopropanol, [Solvent], Polydimethylsi loxane, [Lubricant, Coatings], synthetic bees wax,[Wax], dodecyl benzene sulphonate, [Surfactant], sodium citrate, [Acidifier], Diethylenetriamine penta(methylene phosphonic acid), [Chelating Agent] and dialkly amnionium methosulphate, [Surfactant], low allergen fragrance compound, low allergen fragrance composition.

Group B -Ingredients allowed in the low allergen cleaning product below a specified level The low allergen cleaning product may comprise one or more of the following ingredients. Coconut fatty acid [Surfaciant] at concentrations less than 1.3%, Alkyl Sulphates [Surfactant] at concentrations less than 1.3% or Alkyl Polyglucosides [Surfactant] at concentrations less than 1.3%.

Group C -Ingredients not permitted in the low allergen cleaning product The low allergen cleaning product may not comprise: polydimethylsiloxane, Natural Bees Wax, cetylstcaryl alcohol, Alklycthoxylates, Dipropylene Glycol Monomethyl Ether, Disodiuni EDTA, Ethyl Alcohol, Diazolidinylurea, Methylehloroisothiazolinone, Methylisothiazolinone, Methylisothiazolinone, Chloromethylisothiazolinone, Methylpropan -1 -2 -diol, Monoethanolamine or Triethanolamine, sodium lauryl ether sulphate, sodium laureth sulphate, alkly benzene sulphonate, alpha sulfo methyl ester, alcohol ether sulphates, lauryl sarcosinate, soap, lauryl amine oxide, nonylphenol ethoxylates, oetylphenol ethoxylates, dialkyl dimethyl diammonium chloride, alkyl dime thyl benzyl ammonium chloride, acetone, almond oil, apricot kernel oil, citronella oil, citrus oil, eucolutus oil, lavender oil, pine oil, rosemary oil, sodium hypochlorite, glutaraldehyde.

Group D -Fragrance ingredients not permitted in the low allergen cleaning product Arnyl cinnamal, Benzyl alcohol, Cinnamyl alcohol, Citral, Eugenol, Hydroxy-citronellal, Isoeugenol, Amylcin-namyl alcohol, Benzyl salicylate, C.innamal, Coumarin, Geraniol, Hydroxy-methylpentylcyclohexenecarboxaldehyd, Anisyl alcohol, Benzyl cinnamate, Farnesol, 2-(4-tert-Butylbenzyl) propionald-hyd, Linalool, Linalyl acetate and Styrallyl acetate, Bcnzyl benzoate, Citroncllol, Hexyl cinnam- aldehyd, d-Lirnonene, Methyl heptin carbonate, 3-Methyl-4-(2,6,6-tri-methyl-2-cyclohexen-1-yl)-3-buten-2-one, Oak moss and treemoss extract or Treemoss extract.

A low allergen kitchen cleaner may comprise at least one solvent, at least one surfactant, at least one preservative at least one antibacterial agent and at least one degreaser. The low allergen kitchen cleaner may further comprise at least one low allergen fragrance composition. The low allergen kitchen cleaner may comprise only ingredients selected from group A and/or ingredients selected from group B at the permitted concentration. The low allcrgen kitchen cleaner may not comprise any ingredients from group C or group D. A low allergen multi-surface cleaner may comprise at least one solvent, at least one surfactant, at least one preservative, at least one antibacterial agent, at least one degreaser, and at least one polishing agent. The low allergen multi-surface cleaner may further comprise at least one low allergen fragrance composition. The low allergen multi-surface cleaner may comprise only ingredients selected from group A and/or ingredients selected from group B at the permitted concentration. The low allergen multi-surface cleaner may not comprise any ingredients from group C or group D. A low allergen bathroom cleaner may comprise at least one solvent, at least one surfactant, at least one preservative, and at least one antibacterial agent. The low allergen bathroom cleaner may further comprise at least one low allergen fragrance composition. The low allergen bathroom cleaner may comprise only ingredients selected from group A and/or ingredients selected from group B at the perniitted

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concentration. The low allergen bathroom cleaner may not comprise any ingredients from group C or group D. The proportions or concentrations of each class of ingredient in the bathroom cleaner may be similar to the proportions or concentrations of each class of ingredient in most bathroom cleaners in the art. The proportion or concentration of surfaetant in the bathroom cleaner may be similar to the proportion or concentration of surfactant in most bathroom cleaners in the art. The proportion or concentration of preservative may be similar to the proportion or concentration of preservative present in most bathroom cleaners in the art. The proportion or concentration of antibacterial agent presenting the bathroom cleaner may be similar to the proportion or concentration of antibacterial agent in bathroom cleaners in the art.

A low allergen shower cleaner may comprise at least one solvent, at least one surfactant, at least one preservative. The shower cleaner may further comprise at least one low allergen fragrance composition. The low allergen shower cleaner may comprise only ingredients selected from group A and/or ingredients selected from group B at the permitted concentration. The low allergen shower cleaner may not comprise any ingredients from group C or group D. A low allergen window cleaner may comprise at least one solvent, at least one degreaser, at least one surfactant and at least one preservative. The low allergen window cleaner may further comprise at least one low allergen fragrance composition.

The low allergen window cleaner may comprise only ingredients selected from group A andlor ingredients selected from group B at the permitted concentration. The low allergen window cleaner may not comprise any ingredients from group C or group D. The low allergen cleaning product, for example a bathroom cleaner, may consist of: Aqua, Alcohol (Fermentation Grade), [solvent/degreaser] PEG-40 Hydrogenated Castor Oil [solvent], Cocamidopropyl Betaine,[surfaetant] Citric Acid, a Low allergen fragrance composition, Sodium Gluconate,[surfactant] and Didecyldimonium Chloride [anti-bacterial agent/preservative].

The low allergen cleaning product, for example a shower cleaner, may consist of: Aqua, Alcohol (Fermentation Grade), PEG-40 Hydrogenated Castor Oil, Cocamidopropyl Betainc, Dimethicone, Citric Acid, a Low allergen fragrance composition, Sodium Gluconate, Didecyldimonium Chloride.

The low allergen cleaning product, for example a kitchen cleaner, may consist of: Aqua, Alcohol Fermentation Grade, PEG-40 Hydrogenated Castor Oil, Alkyl Glucoside, Didecyldimonium Chloride, a Low allergen fragrance composition, Citric Acid.

The low allergen cleaning product, for example a multi-surface cleaner, may consist of: Aqua, Alcohol Fermentation Grade, PEG-40 Hydrogenated Castor Oil, Alkyl Glucoside, a Low allergen fragrance composition, Didecyldimonium Chloride Citric, P arfum.

The low allergen cleaning product, for example a window cleaner, may consist of: Water, Alcohol Fermentation Grade, Alkyl Glucoside, PEG-40 Hydrogenated Castor Oil, a Low allergen fragrance composition, Dideeyldimonium Chloride.

Suitable proportions or concentrations of each ingredient or of each class of ingredients, [for example surfactant, solvent, antibacterial agent, acidifier, lubricant or wax] may be used to provide a cleaning product that is capable of perfonnirig the required cleaning activity. The cleaning product of the present invention may have ingredients in each class [for example surfactant, solvent, antibacterial agent, acidifier, lubricant or wax] present at levels similar to those generally used in similar cleaning products in the art.

For example, a surfactarit may be used in a bathroom cleaner at a similar level to the amount of surfactant usually used in bathroom cleaners in the art.

The low allergy cleaning product may be made by combining the chosen ingredients.

In a second aspect the present invention provides a method of making a low allergen cleaning product comprising the steps of: a) deciding which types of ingredients are required in the cleaning product according to the desired use; b) selecting suitable ingredients from group A and/or group B; c) optionally selecting a low allergen fragrance composition; d) optionally combing suitable quantities of the selected ingredients to provide a low allergen cleaning product.

In another aspect the present invention provides use of a method according to the present invention to provide a cleaning product.

In another aspect the present invention provides a cleaning product provided by the method according to the present invention.

In another aspect the present invention provides use of a cleaning product according to the present invention.

In another aspect the present invention provides a method of cleaning comprising the step of applying a cleaning product according to the present invention to a surface.

The method may further comprise the step of producing and packaging the cleaning product.

There now follows by way of example only a detailed description of the present invention with reference to the accompanying drawings, in which: Figure I shows the results of the test of Airborne Particle Concentration for Window Cleaner; Figure 2 shows the results of the test of Airborne Particle Concentration for Shower Cleaner; Figure 3 shows the results of the test of Airborne Particle Concentration for Kitchen cleaner; Figure 4 shows the results of the test of Airborne Particle Concentration for Bathroom Cleaner; Figure 5 shows the results of the tcst of Airborne Particle Concentration for Multi-surface Cleaner; Figure 6 shows a particle concentration graph of 2.5g ATD disturbance on cleaning surface with dry (lusting. Cleaning took place at 300 seconds; Figure 7 shows a particle concentration graph of 2.5g ATD disturbance on cleaning surface with wet dusting. Cleaning took place at 300 seconds; Figure 8 shows a particle concentration graph of 2.5g ATD disturbance on cleaning surface with shower cleaner. Cleaning took place at 300 seconds; Figure 9 shows Par ide concentration graph of 2.Sg ATD disturbance on cleaning surface with window cleaner cleaning took place at 250 seconds; Figure 10 shows a graph of Total Respirable Dust (TRD) levels during cleaning process. A -STEL for TRD (0.45mg/rn3), B -highest recorded TRD levels for dry dusting, C -highest rccorded, TRD level for cleaning with water, D -highest recorded TRD using Shower Cleaner, E -highest recorded TRD using Window C leaner; Figure 11 shows the results of a customer survey carried out on customers who had used the low allergen cleaning products (A) and compared them to other cleaning products they had used previously; and Figure 12 shows the results of a customer survey carried out on customers who had used the low allergen cleaning products (B) and compared them to other cleaning products they had used previously.

In order to create a range of cleaning products containing no or minimal allergens a list was drawn up of suitable no or low allergen ingredients.

Using fonnulation knowledge of what types of ingredients are required in an effective household cleaner an initial list was prepared of potential ingredients which would firstly be effective at cleaning, (both on surface dirt and surface allergens) and would secondly be unlikely to cause asthma or allergy during use. Ingredients on the list were selected to be non contact allergens and by being shown in previous use not to introduce allergens into the air -thus reducing the chances of triggering an asthma attack).

This list was the reviewed against medical and scientific published data on allergic and asthmatic reactions to chemicals. All ingredients associated with an allergic reaction in any way were then eliminated from our formulation list. This left a limited list of ingredients that could be used in order to prepare base formulations for laboratory testing of several different types of household cleaners.

The laboratory testing was carried out by an independent company "air mid" to validate the fact that the ingredients would not introduce allergens into the air during cleaning (air quality analysis in a sealed chamber) and would also be effective at removing known surface allergens such as house dust mite and mould during cleaning.

This has gained the products made from this list of ingredients the accreditation of asthma & allergy friendly' by the independent accreditation body allergy standards.

The products were also tried by asthma & allergy sufferers to assess whether they caused exacerbation of their symptoms in real-life situations.

The products made using this list of ingredients are the first household cleaning products to gain the accreditation of asthma & allergy' friendly.

Previously available products on the market claim to remove surface allergens but they do not also claim to be allergen free themselves and to not introduce allergens into the air during use. Most cleaning products list fragrances known to be allergens as part of the ingredient list. Even if these allergens are at a level too low to require declaration on the pack, many of these allergens are still present in the fragrance and will pose a potential hazard to some individuals.

Looking at the declared ingredients on packs of traditional cleaning products, eco cleaning products and so called sensitive' cleaning products it is obvious that these products all still contain ingredients that arc known allergens. Traditional cleaning products may contain lower levels of allergens that are at a level where they do not need to be declared on the pack.

The cleaning products of the present invention are advantageous because they do not contain any allergens, even at levels that do not need to be declared by law. The products of the present invention arc further advantageous because they still have an effective cleaning action while having no allergens in the composition. The cleaning products of the present invention are also advantageous because they may comprise fragrances but do not comprise allergenic fragrance compounds even at levels that do not legally need to be declared on the packaging. This is advantageous because consumers like to use fragranced products. The products of the present invention can safely be used by asthma and allergy sufferers who like to use fragranced cleaning products.

The cleaning products of the present invention do not introduce allergens into the air when used.

The advantage of having this product is that people who suffer from asthma or allergy can use this product as part of a lifestyle choice to reduce their chances of having an allergic reaction or asthma attack triggered. This advantage is two fold, both by removing surface allergens and by not introducing further allergens into the air or onto surfaces during use.

The present invention solves the problem of providing a cleaning product that is effective at cleaning dirt and allergens but also does not expose the user to allergens or introduce allergens into the environment.

The present invention also solves the problem of providing a fragranced cleaning product that is effective at cleaning dirt and allergens but also does not expose the user to allergens or introduce allergens into the environment.

The present invention further solves the problem of providing a fragranced or non-fragranced cleaning product that passes the accreditation of the allergy standards accreditation body as an asthma and allergy friendly product and is as effective as other cleaners.

A range of products according to the present invention were reviewcd to ensure that their ingredients were low-allergen ingredients and that they gave acceptable levels of allergens on surfaces and in the air during use.

ASC Code Product Description

ASC002249 Asthma Kitchen Cleaner Formulation Code: 2/1241/1. Date 27.11.2012 ASC002250 Asthma Window Cleaner Formulation Code: 2/1247/1. Date 28.11.2012 ASC002252 Asthma Multisurface Clcaner Formulation Code: 2/1242/1.

Date 27.11.2012 ASC002253 Asthma Bathroom Cleaner Formulation Code: 2/1235/1. Date 19.11.2012 ASC002254 Asthma Shower Cleaner Formulation Code: 2/1238/1. Date 20.11.2012 Test Request Representative samples of each of the above products were reviewed and tested for suitability for use by those with asthma and allergies.

Testillg Summary

1. Constituent Review 2. The Product a. Airborne Chemical Profile b. Airborne Particle Concentration 3. Cleaning with the Product a. Airborne Particle Concentration during Cleaning b. Airborne Allergen Concentration during Cleaning c. Surface Allergen Removal during Cleaning.

1. Collstituent Review Constituents present at concentrations ? 0.05% in final product.

Bathroom Cleaner Table 1 Bathroom Clealler Bathroom CLeaner Ingredlient CM number ConcentratIon (%) 1. Aqn 732-18-5 up to 100 3. Et} and (ferrneitation grade 54-F'-S 9.47 3. P56-40 hydiogenate cask.r f:.1733$50 0 9996 4. Cocarn'op op1 betaine 61789-40-0 0 5 5. &ojurn hjdde 764T-14-5 0.1 6. Glvcen.i ss-ai-s a as 7. Ctt aS 77-92-9 1 3. oJrn g conate 527-07-1 (105 9. DLe:yk$in onum Jiloride 7173-51-S (12 10. spro a.id 57-53-0 003 8. Fng.ance (PF 710fl mixture (136 Table 2 Shower Cleaner Shower Ckaner Ingredient AS number oncentration 4W4 I Aqua 732-1S-5 upto 100 2. Etharo (Fermentation grade 54-17-5 947 3. PEG-dO hycfrogenatet. castor ed 61788-55-0 1.175 4 cocandopropyl betaine:61789400 0.5 : Sodum c:rkte 7447-14-5 0.1 6. G'ycerin 5 1-5 0.06 7, D'n ethkone 9005-65-9 00624 8 Gt1cact 77-92-9 1 S. So&um gkconate 527-07-1 0.05 9. Ddecjdinc&niumchk ide 7173-51-5 0,2 IC. soproparw 57-63-0 0.08 9. F ag arce PF 7&02) rnxture 0.3 Table 3 Kitchen Cleaner Kitchen Cleaner Ingredient CAS number Concentration 4%) 1. Aqua 77 32-1:-s up to ICC . Etharo ferrnentatien grade 54-17-5 9.47 PEG-40hydrogeiateo astcrofl 51788-85-0 0.784 4. Ddeq?krmcnium chiortde 7173-51-5 0.2 5. sopropanu1 67-63-0 0.08 E. Me.l gULosHe 11051.5-47-9 1.3 7..So t i hydide 1310-73-2 qs 3. Fnrarce PE 74098 mixture 0.29 Table 4 Multi -surface Cleaner Mutt-swtace Ueaner Ingredient AS number concentretion %) 1. Aq. 7712-18-5 up to 100 2. Ethanol fenm.otabon grade) 64-0-5 5.47 3. PEG-C ycroge ated castor oH 61788-85-0 098 4. Dicecyldrnonwrn chior c 7173-51-5 C.2 S. sopropa o 67-63-0 0.08 6,Akyg1uco;ide 110615-47-9 055 . Fragrance (PF 7400) rnxture 0.3 Table 5 Window Cleaner Windøw Cener tngredient CM number Concentration 1%) 1. Aqua 7732-13-S up to 100 2. Eliiano 1ferrnent?Uon grade M-17-5 5.682 3. PEGdt hycroaenated castor oil 51788-35-C 049 4. DidecySnnniurn cilonde 7171-51-S 0.2 5. scprop-ar'o 57-63-0 0.03 S A1kgiucoide l1osLc-4-9 ft065 6. Fragrance PF 74O97 m ture 0_i Review of Ingredients 1. Aqua No concerns.

2. Alcohol (fermentation grade) (C.AS No. 64 -17 -5) 5.682 -9.47°A concentration Ethanol has a low order of acute toxicity by all routes of exposure. Ethanol is a moderate eye irritant but is neither a skin irritant nor a sensitizer.

3. PEG -40 hydrogenated castor oil (CAS No. 61788 -85 -0) 0.49 -1.176% concentration PEG Hydrogenated Castor Oils are a family of polyethylene glycol derivatives of hydrogenated castor oil that are used in over 500 formulations including cosmetic products. They are used as surfactants that function as emulsifying or solubilizing agents. The PEG Hydrogenated Castor Oils include various chain lengths, depending on the quantity of ethylene oxide used in synthesis.

Undiluted PEG 40 Hydrogenated Castor Oil was found to cause mild transient dermal irritation and slight transient ocular irritation in rabbits. However 0.25% PEG 40 Hydrogenated Castor Oil was observed to produce minimal signs of skin irritation in rats. 20 hun-ian subjects were patch tested with 100% PEG 40 Hydrogenated Castor Oil on the skin of their backs. No signs of irritation were observed after 24 and 48h.

No evidence of sensitization was shown in clinical studies with formulations containing either 0.05% (120 volunteers, carried out in 1977) or 0.25% PEG -40 Hydrogenated Castor Oil (86 subjects, carried out in 1982).

4. Cocamidopropyl betaine (CAS No. 61789 -40 -0) 0.6% concentration The irritation potential of the surfactant cocamidopropyl betaine is dependent on concentration. Neat and approx. 30% active formulations of cocamidopropyl betaine are irritating to the skin and the eyes, while 10% active solutions caused only mild skin and eye reactions. In human studies up to 3% solutions were weakly irritating.

Impurities like arnidoamine (see below) may contribute to irritation reactions.

Potential irritation of the respiratory tract is not a concern given the very low levels of airborne cocamidopropyl betaine generated as a consequence of cleaning sprays aerosols.

Contact allergy to cocarnidopropyl bctainc has bccn rcportcd, indccd incrcasing ratcs of sensitization led to it being named Allergen of the Year in 2004. However, in humans, the sensitizing potential of cocamidopropyl betaine is said to be low. In recent years, numerous studies have repeatedly indicated that cocamidopropyl betaine is not actually an allergen and impurities present in commercial cocamidopropyl bctainc (dimethylaminopropylamine and/or amidoaminc, a starting material and a manufacturing intermediate from production), are responsible for causing skin sensitization. Cocamidopropyl betaine of suitable purity, where levels of both amidoamine and dimethylaminopropylamine are minimized (<0.1% and <10 ppm, respectively), is unlikely to trigger reactions in thosc ostensibly allergic to the material. The final levels of amidoamine and dimethylaminopropylamine in the finished low allergen cleaning products have been declared as 0.006% and 0.00004% respectively.

5. Dimethicone (CAS No. 9006 -65 -9) 0.0624% concentration Dirnethicone can act as an antifoaming agent. It is not thought to be acutely toxic.

Most dermalirritation studies using rabbits classified dimethicone as a minimal irritant. Dimethicone, applied in a 24h occlusive patch to the forearm, produced no irritation in 54 men. Dimethicone (tested undiluted and at 79°A) was not a sensitizer in four assays using mice and guinea pigs. It was not a sensitizer at 5.0% in a clinical test using 83 human panellists. While a few studies reported severe reactions, most ocular irritation studies using rabbits classified Dimethicone as a mild to minimal irritant.

6. Citric acid (CAS No. 77 -92 -9)1% concentration Based on many experimental data in animals and on human experience, citric acid is of low acute toxicity. The NOAEL (no observable adverse effect level) for repeated (lose toxicity for rats is 1200 mg/kg/day. The sensitising potential is seen as low. In contrast, irritation, in particular of the eyes but also of the respiratory pathways and the skin, is the major toxicological hazard presented by citric acid; this conclusion is confirmed by a series of reports relating to eye and skin irritation. However in human studies, citric acid was not a dermal irritant at concentrations of up to 5% aq. and even in 60 eczema patients patch testing with 2.5% citric acid in petrolatum did not produce any irritant or allergic reactions.

7. Sodium gluconate (CAS No. 527 -07 -1) 0.05% concentration The NOAEL of sodium gluconate determined from 28 day studies on rats was equal to 1000 mg/kg bw for males and 2000 mg/kg 5w for females. These compounds are neither irritant to the eye or the skin nor show sensitizing properties. Individual exposure of consumers to gluconates is expected to be limited because gluconates are mostly used as additives in the different consumer products typically in low dosages.

8. Didecyldimonium chloride (C.AS No. 7173 -51 -5) 0.2% concentration Didecyldimonium chloride, also known as didecyl dimethyl ammonium chloride (DDAC.) is a quaternary ammonium compound that is slightly volatile and that can be used as a disinfectant. Only limited information on the toxicology of DDAC is available in literature. Moderate dermal irritation was found after exposure to 5 and 0.5% DDAC, though no irritation occurred with 0.1%, 0.05% and 0.005% (not specifically stated but seems to be based on animal studies). A piece of woollen fabric impregnated with 0.25% DDAC did not cause skin irritation in humans during 48 hour exposure. A study with human volunteers did not show skin irritation in 49 out of 50 subjects after exposure to 0.05% up to 0.5% DDAC, and in the remaining subject slight irritation at concentrations of 0.25% and 0.5%. As of May 201 I, two cases of occupational allergic contact dermatitis in hospital employees caused by DDAC and proven by positive patch test results (one case reacted to concentrations of0.01 and 0.1°A the other case reacted to 0.1%) and two of immediate -type allergy to DDAC (one case reacted to concentrations of 1 and 10% the other appeared to have a reaction following the spraying of a disinfectant containing DDAC, concentration not given) and a case of severe contact urticaria after occupational exposure to DDAC. (at concentrations of 10, 2 and 0.5%) have been report e (I.

However reactions to DDAC are still described as "rare". Exposure to and risks of DDAC resulting from the use of hygienic cleaning spray cleaners for cleaning the kitchen working top were assessed in a report by the Dutch government agency. The National Institute for Public Health and the Environment (RIVM). The conclusion of this risk assessment was that the oniy adverse health effect that might occur due to the use of DDAC containing hygienic cleaning trigger spray is slight dermal irritation.

Their results suggest that contact with undiluted product containing 0.2% DDAC might lead to slight eiythcma in sensitive humans. They state that due to the lack of toxicity data following inhalation exposure, it is impossible to predict the occurrence of adverse health effects, but when considering the dcrmal and oral irritating properties of the compound, it might be possible that the compound causes irritation effects on the respiratory tract as well.

9. AIkyl glucoside (CAS No. 110615 -73 -2) 0.065 -1.3% concentration This C.AS number refers to a medium/long alkyl chain length (C12 -14) alkyl glucoside also known as lauryl glucosidc. The irritation potential of alkyl glucosidcs decreases with increasing chain length. According to a Safety Assessment by the Cosnietic Ingredient Review, in dermal irritation studies (2% concentration, 20 subjects and 1% concentration 22 subjects) lauryl glucoside was found to be "slightly irritating". Allergic contact reactions to glucosidcs are said to be "uncommon" however C.14 glucoside may cause skin sensitization at concentration of 5.9%.

Glucosidc sensitization appears to be a group allergy reaction, with cross -reactions between different akyl glucosides representing the norm. There were three case reports of reactions to lauryl glucoside between 2006 and 2010, but the causal products were cosmetic (hair care and body cleansing) i.e. products applied directly to skin therefore the exposure to the consumers was much greater than would be expected when using a cleaning product.

10. Sodium hydroxide (CAS No. 1310 -73 -2) "qs" concentration Depending on the concentration, solutions of sodium hydroxide are non -irritating, irritating (0.5 -2.0% concentration, based on human data) or corrosive (?2.0% concentration). Animal eye irritation studies concluded that the non-irritant level was 0.2 -1.0%, while the corrosive concentration was ?1.2%. A study with human volunteers did not indicate a skin scnsitisation potential of sodium hydroxide. This is supported by the extensive human experience. Sodium hydroxide has a negligible vapour pressure and is rapidly neutralized in air by carbon dioxide and therefore dust and vapour exposure are not expected. Indeed, according to an EU risk assessment based on the use of an oven cleaner in a spray can containing 5% sodium hydroxide, "because of... short -term use and the fact that sodium hydroxide is unstable in air, inhalatory exposure following the use of oven cleaners is considered to be negligible".

The risks associatcd with the correct use of a cleaning product containing trace amounts of sodium hydroxide would be expected to be low.

11. Sodium Chloride (CAS No. 7647 -14 -5) 0.1% concentration Sodium chloride is of such low toxicity that only mild nasal irritation is experienced by drillers in salt mines, even when dust levels exceed occupational exposure limits.

Sodium chloridc at concentrations much above that in tears causes a stinging sensation on contact with the eye.

12. Glycerin (CAS No.56 -81 -5) 0.06% concentration The weight of evidence indicatcs that glycerin is of low toxicity when ingested, inhaled or in contact with the skin. Glycerin has low potential to irritate the skin and the eye. The available human and animal data, together with the very widespread potential for exposure and the absence of case reports of sensitisation, indicate that glycerin is not a skin sensitiser.

13. Isopropanol (CAS No. 67 -63 -0) 0.08% concentration Very high concentrations of isopropanol vapour are irritating to the eyes nose and throat. When tested on the skin of human volunteers, isopropanol produced little irritation, however there have been reports of isolated eases of dermal irritation and/or sensitization. Isopropanol is considered to be a weak and infrequent sensitizer.

Of 1450 patients patch tested with 100% isopropyl alcohol during the period 1992- 2011, forty -four showed an allergic response. However this study was subsequently questioned as a dilution of 10% is recommended for patch testing with isopropanol. A human health risk assessment concluded that the use of isopropanol in household laundry and cleaning detergents can been considered safe and does not cause concern with regard to consumer use.

14. Fragrance The fragrance constituents have been reviewed directly with the fragrance house.

Constituent Conclusion

While cleaning, people are potentially exposed to compounds emerging from cleaning products. Whilc applying thc product (spraying), inhalation cxposurc can occur whcn droplets of the product are inhaled or if/when the constituent of interest evaporates from the droplets. During clcaning, inhalation exposure occurs as a rcsult of evaporation from the product sprayed on the surface of interest. Skin contact can occur when wiping the surface, to remove the product. Potentially, oral exposure can occur via hand-to-mouth contact. Ocular exposure is possible due to hand-eye contact or splashes. Correct usc of thc product according to providcd instructions should ensure that oral and ocular exposures are negligible.

Thc constituents of the products havc been reviewed in detail and finalised in discussions and finalised to create low allergen/no allergen cleaning products. While it is impossible to eliminate risk completely, the review aimed to significantly reduce the likelihood of adverse consumer reactions by selecting constituents considered only minimally irritating/sensitising, strictly limiting the presence of impurities and using constituents at their lowest functional concentration.

The Product a. Airborne Chemical Profile Shower & Kitchen cleaner were chosen as representative samples based on formulations and were tested for VOC emission according to ASTM D116 -10 small chamber test and California specification 01350 Test Methods.

The samples were prepared by spraying 3 full pulls of the trigger, equating to 2 grams, onto a glass substrate at a distance of 30cm above the glass, counting to 10 seconds and immediately placing the samples in thcir individual chambers. The results are shown in the tables 6 and 7 below.

Table 6 Small Chamber VOC Profile of Kitchen Cleaner A50002249 Asthma Kftden fl&aier Formuadon Code: 2/1241/1. 0te 27.11.2012 Private office Pth.te office window. IZ window: 9G mm Modaled mm Modeled Ar Cone. Air Conc.

CAS # Compound Name rng(m GC>'MS Trqet nak 141-78-6 Ethy aoate 0.002 0.001 108-88-3 Tduene 0.001 0.000 594-76-5 2-Hexnone 0.1300 0000 Xy4eres 0.001 0.000 GUA4S T!CcVL(ucn31 625-69-4 2:4-Pentanedk 0.030 0.003 554-59-6 3,77-Tnmethyi h:!CCfO4.T:.0J heptane 0i303 0.001 30159-12-1 Tncv0o[73.O.0(2.6] dodeane 0.001 0.000 55253-28-6 Phctodtr A 0.000 0.000 18470-59-0 2thio-meto.y octanol 0.012 0.007 544-25-2 1,35-Cnloheptatrene 0.001 0.000 None Benz4bydoxypropa:nate 0.000 0.000 96-52-2 4-1 1-d'methylethyU cyclohexanol 0.000 0.000 i3491-19-7 2-(l -diEnelhy!eThyL nyclohxanoi 0.000 13.000 41977-45-1 7-PenM byc.Lo[4.1.0]: heptane 0.000 0.000 99-80-5:. 4--merhyle.thvi) phnol 0.000 0.000 14202-3 -4 -kobotviidene-3-roethyl ovolopentane 0.039 0.5010 HPLC Aldehydes. no/L (uo4n3 50-00-0 Formaklehvde 0.000 0.000 75-07-0 Acta0lohyde 0.000 0 500 TVOCs 0.090 0.013 Requirement 1.000 0.500 Table 7 Small chamber VOC Profile of Shower Cleaner Asc:002251 Asthma Shower Cener Fornm6don Code: 2/123511. E}at.u 20.11.2012 Pñvte oftic Printe office window: 15 window: 0 rtiin Modeled mm Wothkd Air Cone.. Air Conc.

CAS # Compound Nrne mg/m3 GC:fl4S Twq&t q*i (Lk:L4Th3Y 1:41-78-6 Ethyiaetate 0.003 IOA-8$-3 Toluen 0.00 0 000 391-75-6 2-Hexanone O.i01 0.000 Xvlenes 0.004 0.001 GC4I4S flCs. aWL (E1CilTh31 625-69-4 2$-Penenedk1 0.158 0.044 554-59-6 3.7:7Trt:1y hicc1oi4.l 0 0.009 0004 30159-12-7 Thcwcloi7.3.t].0 4oecane ft013 0005 5525:3-28-C Pholocitrad A 0.002 0 001 9473-59-9 2ret?M,_metbv octano 0.017 0.012 544-25-2 1.3,5-0ycIohepaWe.ne 0.002 0.002 None Benr1hydoxvpropenate 0:01.4 0.006 38-52-2 4-(1.1-dethylethy1 cycioxa.no} 0.013 0.008 v:;4&_7Q_7 2-(1 1-dinietiwlehyFi cco5exanot 0.004 0.003 41977-43-1 7-F'ewb:colo(4.l.0lrieptane 0.001 0.000 4-(1-methveth'$) pherol 0.002 0 001 70-49-3 Borny ocetato 0.057 0017 HPL..:.4;0ehvder. naL (UQuITCt Forrnuk1h?ds 0.000 0.000 75_fl j_Q Acetakiehyde 0.011:0 0000 TVCC 0.279 0_lOT Requirement 1.000 0.500

S

To allow for variation of formulation and fragrance differences within thc cleaning product range all 5 products were screened for TVOC according to a Full Scale Chamber Test in a large environmental test chamber. The initial background measurements were made before each product was used. The products were applied to a marked table area of 30cm x 30cm. 3 full pulls of the trigger, equating to 2 grains, were sprayed from a height of 3 0cm. TVOC measurements were made at a height of 38cm2 every 5 seconds for a 100 minute duration. The results summary is given in

table 8 below.

Table 8. TYOC Screening of all 5 cleaning products in large chamber Bathroom l<tchen Multi-5uJace Shower Mridow mes 0.00 0.00 0.00 0.00 ace mns 000 000 0.00 0.0C 000 Average 0.00 0.01 0.04 0.01 000 Max 009 0.12 241 0.30 ftOO rLVO o.tj 0.uO 0.00 b. Airborne Particle Concentration Five products were screened for particles according to a Full Scale Chamber Test in a largc environmcntal tcst chamb cr. Thc initial background mcasurcmcnts werc made before each product was used. The products were applied to a marked table area of 30cm x 30cm. 3 full pulls of the trigger, equating to 2 grams, were sprayed from a height of 30cm. Particle count measurements were taken using a laser particle counter set at a height of 38cm2. Measurements were taken 10 minute duration at 0 minutes (background), 15 minutes and 90 minutes. The graphs are shown in Figures 1 to 5.

3. Cleaning with the Product a. Airborne Particle Concentration during Cleaning Window Cleaner and Shower Cleaner were chosen as representative samples to show the disturbance of dust during cleaning by particle measurement. The results are shown in Figure 6 for dry dusting and Figure 7 for wet dusting.

During cleaning the short term exposure limit value for total respirable dust must not exceed 1/1 (0.45 mg/m3) in the absence of respiratory protection.

Table 9 Airborne Allergen Concentration during Cleaning Peldl(p) C een rig Type 1 2 3 Avere Dry Dtatfng Water Dry Dustthg 11557 L5: ±87 369u1 Water 0 164.87 430175 146867 Na Na Shower Ceaner 7tI I. 0 25156 163.49 4431 3.74 Window cleaner o 1.53.34 Sill 13.85 Amount of cat allergen (Fel dl) detected on filter at height of 61cm for a given amount of challenge ATD; run iii triplicate.

*pg -picogranis (10 -12 gram).

% calculated by expression of average allergen (pg) of cleaning with Window and Shower Cleaner as a percentage of average allergen (pg) of cleaning without cleaning product (i.e. dry dusting & water).

Na = Not applicable.

Requirement: Capability to effectively remove surface allergen from hard surfaces by thorough cleaning while generating airborne allergen amounts less than 25% of the dry (lusting control and less than 75% of the water cleaning control.

a. Demonstrable for one or more of thc allergens tested.

Table ba Surface Allergen Removal during Cleaning : .iakt i.i......%.i..... :a:i: I*_ I*iEi:. : 1 557.5 11150 1 2125 42500 2 147.5 2950 2 18000 352000 3 275 5500 3 4300 86000 Do' Oustn3 4 237.5 5750 Wet Wipe 4 2550 51000 _______ _________ 240850 _______ _________ 1039000 300 6000 ControU1 5 3050 61000 172.5 3450 6 14000 233000 7 207.5 4150 7 7225 144500 3 10100 202000.4 700 14000 1 9800 195000 1 3850 77000 2 9125 132500 2 4875 97500 3 6675 133500 3 23750 575000 Dry [3usOn3 4 75750 1575000 Wet Wipe 4 82250 1&5000 _______ _________ 4358000 _______ _________ 4570000 83500 1670000 coflrcl 2 5 12000 140)000 & 3000 734* 5 10575 211500 7 26:50 533200 7 2700 5L000 3 23500 470000 8 28500 572000 8850 177000 1 1750 35000 2 36250125000 2 3225 SLSOO 3 5625 132500 3 3050 73000 Do Dust3n 4 25750 575500 Wet Wipe 4 8500 195000 _______ _________ I048000 _______ _________ 1053500 S 41500.830500 (Iontro 5 3650 73093 25250 525000 5 gso 197000 7 5175 163500 7 12050 241000 S 45000 620000.4 8950 179000 Mould recovery from sampling sites after dry and wet dusting. 8 sampling sites were used arid the total for the 8 sites calculated.

Table lOb :i

UA hh' i5&4 -.

1 1550 33000 1 132.5 2650 2 1700 34000 2 1179 2350 3 1550 330352 3 50 200 Shower C5aner 4 725 145033 Window Ceaner 4 15 394 _______ _______ 235250 _______ ______ 48050 #5 5 2200 44050 41 S 2525 40500 6 2575 52590 6 45 990 7 287.5 5750 7 30 600 8 675 13500 8 27.5 550 1 950 29090 1 10 290 2 3975 51500 2 37.5 750 3 2550 51000 3 35 700 Shower C!ear::er 4 2050 41000 Window Seener 4 22,5 450 _______ _______ 229150 _______ ______ 10200 #2 5 1550 313500 42 5 55 1100 O 750 15000 5 2,5 50 7 25 650 7 37.5 750 8 350 7000 8 310 6205 1 82.5 1650 5 30 500 2 2.5 650 2 25 500 3 55 1100 3 0 0 Shower Ceaner 4 20 400 Window Ueaner 4 32.5 550 _______ _______ 7150 _______ ______ 5850 #3 5 102.5 2050 43 5 915 1850 O $2.5 550 5 50 1200 7 12.5 250 7 10'J 2000 8 20 400 8 2.5 50 Mould recovery from sampling sites after cleaning with shower cleaner and window cleaner. sampling sites were used and the total for the 8 sites calculated.

Table bc

Summarised ro}d Data Tcte:ki'fi Aefsg Tcta eft RSthton Re<Cn 2 ir9 Dost (We Dtst) Dry Dutiig 240950 435S000 4048000 2882317 57345&5 N/A N/A Wet Dutr 1038000 4870000 1C:5500 2255233 45342250 N/A 5bowrCkner 235250 220150 7150 156183 3139285 9459% 93.0% W5dwCea.ner 48050 10260 6259 21700 435170 9215 90.04% Summary of Mold data. The total recovery (Total cfu's/run) is expressed as an average. As the area sampled represents 20.1%* of the total sample area this is then expressed in terms of 100%** of the sample area. The relative reduction is calculated as a perccntage of thc concentration rccovcred after dry and wet dusting.

* This average value represents 20.1% of the surface area.

** This value represents 100% of the surface area.

Requirement: Capability to remove surface allergen from hard surfaces, when compared to controls not incorporating the cleaning product, by greater than 85% a. Demonstrable for one or more of the allergens tested b. Demonstrable for both controls.

Table ha Allergen Recovery from the Cleanifig Cloth Reb i.ekk4 DerpITRM.g) Aveage tenThton ________ ________ ________ ne

TM

Run R n2 Run 3 D Dust Wt Dut Dytst 1358 952 137± 13.2 N/A N/A Wet ftst 2937 2889 1.62 25.43 1.91 N/A nds C'eat e 37 19 47 90 -L49 44.19 333 1.73 iwe. Ue.nei 1357 4790 4049 55.25 4.19 2.13 Recovered House Dust Mite (Der pi) allergen from cloths used for assessing the removal of allergen with or without client product. The fold increase in allergen retention is expressed relative to dry dusting and wet dusting where applicablc.

Table lib C.

P"lpSTRAutgj 4erage Conthttcr _________ __________ _________ ft reat.

Rui I Run 2 \ 3 TM Di Dust Wet Duct Dry Dust 34.44 3536 34.03 34.78 N/A N/A Wt Dust.8432 104.79 129.55 105.22 3.05 N/A Window Ceaner 156.72 234.49 24149 210.90 1.98 Shower Deaner 407.74 314.04 256.52 326.10 937 3.07 Recovered Pollen (Phl p5) allergen from cloths used for assessing the removal of allergen with or without client product. The fold increase in allergen retention is expressed relative to dry (lusting and wet dusting where applicable.

N/A = Not applicable.

Low Allergen Fragrance Example Seven ingredients were approved for use in low allergen fragrance compounds. All of these ingredients were reviewed to cnsure that they do not cause or exacerbate allergic reactions, in particular of the eyes, skin and respiratory system. These ingredients were also reviewed to ensure that they are not irritating to the skin, eyes or respiratory system.

These seven ingredients form a panel of low allergen fragrance compounds from which low allergen fragrance compounds can be selected to provide a low allergen fragrance composition.

Each of the five cleaning products comprised a low allergen fragrance composition consisting essentially of 5 or 6 low allergen fragrance compounds selected from the panel of seven low allergen fragrance compounds.

Each low allergy fragrance composition comprised a balance of low allergen fragrance compounds selected to achieve an aesthetic and relevant fragrance effect to the cleaning product that the fragrance composition was used in. The fragrance composition was designed to provide a suitable fragrance to the particular cleaning product that was pleasant to the user and relevant to the designated use of the product.

Two examples of the compounds included in the panel of low allergen fragrance compounds are ortho tertiary butyl Cyclo hexyl acetate and Dihydro rriyrcenol.

Both of these compounds have been known since the 1960s and 1970s and have seen increased use by the fragrance industry year by year.

Ortho tertiary butyl Cyclo hexyl acetate is a fresh woody green ingredient used across a multitude of fragrance applications and odour styles. It is an important ingredient in a wide range of toiletry and household products and can also be used in some fine fragrance styles. It has excellent chemical stability and was approved by Airmid as a low allergen fragrance ingredient.

Dihydro myrcenol is a fresh, clean aroma lending itself to citrus, herbal and outdoors aromas and a strategic element of many modern male fine fragrances. It has very good chemical stability and was also approved by Airmid as a low allergen fragrance ingredient.

Both Linalyl acetate and Styrallyl acetate were rejected by Airmid as low allergen fragrances for use in the low allergen cleaning products. Airinid's assessment of these compounds found that they had too high irritation and sensitisation potential. These ingredients add dimensions to the citrus and floral elements when used in fragrance creation.

Claims (12)

1. CL Al NI S 1. A low allergen cleaning product comprising one or more ingredients sclected from: Aqua, Alcohol (Fermentation grade ethanol), PEG Hydrogenated Castor Oil, PEG 40 Hydrogenate Castor Oil, Cocamidopropyl Betaine, PEG 12 Dimethicone, Dimethicone, Citric Acid, Sodium Gluconate, Didecyldimonium Chloride, Alkyl Glucoside, Sodium Hydroxide, Sodium Chloride, Glycerine, Isopropanol, polydimethylsiloxane, synthetic bees wax, coconut fatty acids, dodecyl benzene sulphonate, sodium citrate, alkyl polyglucoside, Diethylenetriamine penta(mcthylene phosphonic acid), polydimethylsiloxane and dialkly ammonium methosulphate, a low allergen fragrance compound, a low allergen fragrance composition.
2. 2. A low allergen cleaning product according to any one of the preceding claims wherein the cleaning product does not comprise: Anti-foam (DB I 1OA) polydimethylsiloxane, Natural Bees Wax, cetylstearyl alcohol, Alklyethoxylates, Coconut Fatty Acid, Dipropylene Glycol Monomethyl Ether, Disodium EDTA, Ethyl Alcohol, Diazolidinylurea, Methylchloroisothiazolinone, Methylisothiazolinone, Methylisothiazolinone, Chloromethylisothiazolinone, Methylpropan -1 -2 -diol, Monoethanolamine or Triethanolamine, sodium lauryl ether sulphate, sodium laureth sulphate, alkly benzene sulphonate, alpha sulfo methyl ester, alkyl polyglucoside, alcohol sulphates, alcohol ether sulphates, lauryl sarcosinate, soap, lauryl amine oxide, nonylphenol ethoxylates, octylphenol ethoxylates, dialkyl dirnethyl diammonium chloride, alkyl dimethyl benzyl ammonium chloride, acetone, almond oil, apricot kernel oil, citronella oil, citrus oil, eucolutus oil, lavender oil, pine oil, rosemary oil, sodium hypochlorite or glutaraldehyde.
3. 3. A low allergen cleaning product according to any one of the preceding claims further comprising one or more of: Coconut fatty acid [Surfactant] at a concentration less than 1.3%, Alkyl Sulphates [Surfactant] at a concentration less than 1.3% or Alkyl Polyglucosides [Surfactant] at a concentration less than 1.3%.
4. 4. A low allergen cleaning product consisting of ingredients selected from those listed in claim 1 and/or claim 3.
5. 5. A low allergen cleaning product according to any one of tile preceding claims, wherein the cleaning product comprises at least one solvent, at least one surfactant and at least one preservative.
6. 6. A low allergen cleaning product according to any one of the preceding claims comprising a low allergen fragrance composition.
7. 7. A low allergen cleaning product according to any one of the preceding claims wherein the low allergen fragrance composition does not comprise: Amyl cinnamal, Benzyl alcohol, Cinnarnyl alcohol, Citral, Eugenol, Hydroxy-citronellal, Tsoeugenol, Amylcin-namyl alcohol, Benzyl salicylate, Cinnanial, C.oumarin, Geraniol, [-lydroxy-methylpentylcyclohexenecarboxaldehyd, Anisyl alcohol, Benzyl cinnamate, Farnesol, 2-(4-tcrt-Bulylbenzyl) propionald-hyd, Linalool, Bcnzyl bcnzoatc, Citronellol, Hexyl cinnam-aldehyd, d-Limonene, Methyl heptin carbonate, 3-Methyl-4-(2,6,6-tri-nlethyl- 2-cyclohexen-1-yl)-3-buten-2-one, Oak moss and treernoss extract or Treemoss extract.
8. 8. A low allergen cleaning product according to any one of the preceding claims wherein the cleaning product is a household cleaning product.
9. 9. A low allergcn cleaning product according to any one of tile preceding claims wherein the cleaning product is a bathroom cleaner, a shower cleaner, a kitchen cleaner, a multi-surface cleaner or a window cleaner a polish, a granite and marble cleaner, a stainless steel cleaner, a hob cleaner, an oven cleaner, a mould & mildew cleaner, a bike cleaner or a car cleaner.
10. iO. A low allergen cleaning product according to any one of the preceding claims wherein the product is suitable for removing household dirt and allergens from hard surfaces.
11. ii. A low allergen cleaning product according to any one of the preceding claims wherein the product comprises: a solvent, a surfactant, a preservative an antibacterial agent, a polishing agent a degreaser, an antifoaming agent and a fragrance.
12. 12. A low allergen kitchen cleaner according to any one of the preceding claims comprising at least one solvent, at least one surfactant, at least one preservative at least one antibacterial agent, at least one degreaser and optionally at least one low allergen fragrance composition.S13. A low allergen multi-surface cleaner according to any one of claims 1 to 11 comprising at least one solvent, at least one surfactant, at least one preservative, at least one antibacterial agent, at least one degreaser, and at least one polishing agent and optionally at least one low allergen fragrance composition.14. A low allergen bathroom cleaner according to any one of claims I to 11 comprising at least one solvent, at least one surfactant, at least one preservative, at least one antibacterial agent and optionally at least one low allergen fragrance composition.15. A low allergen shower cleaner according to any one of claims 1 to 11 comprising at least one solvent, at least one surfaetant, at least one preservative and optionally at least one low allergen fragrance composition.16. A low allergen window cleaner according to any one of claims 1 to 11 comprising at least one solvent, at least one degreaser, at least one surfactant, at least one preservative and optionally at least one low allergen fragrance composition.17. A low allergen cleaning product according to any one of claims I to 11 consisting of: Aqua, Alcohol (Fermentation Grade), PEG-40 Hydrogenated Castor Oil, Cocamidopropyl Betaine, Citric Acid, a Low allergen fragrance composition, Sodium Gluconate, and Didecyldimonium Chloride.18. A low allergen cleaning product according to any one of claims 1 to 11 consisting of: Aqua, Alcohol (Fermentation Grade), PEG-40 Hydrogenated Castor Oil, Cocamidopropyl Betaine, Dimethicone, Citric Acid, a Low allergen fragrance composition, Sodium Gluconate, Didecyldimonium Chloride.19. A low allergen cleaning product according to any one of claims I to II consisting of: Aqua, Alcohol Fermentation Grade, PEG-40 Hydrogenated Castor Oil, Alkyl Glucosidc, Didecyldimonium Chloride, a Low allergen fragrance composition, Citric Acid.20. A low allergen cleaning product according to any one of claims 1 to 11 consisting of: Aqua, Alcohol Fermentation Grade, PEG-40 Hydrogenated Castor Oil, Alkyl Glucoside, a Low allergen fragrance composition, Didecyldimonium Chloride, Citric, Parfum.21. A low allergen cleaning product according to any one of claims 1 to 11 consisting of: Water, Alcohol Fermentation Grade, Alkyl Glucoside, PEG-40 Hydrogenated Castor Oil, a Low allergen fragrance composition, Didecyldimonium Chloride.22. A method of making a low allergen cleaning product comprising the steps ot a) deciding which types of ingredients are required in thc cleaning product according to the desired use; 5) selecting suitable ingredients from the list consisting of: Aqua, [Solvent], Alcohol (Fermentation grade cthanol), [Solvent], PEG 40 Hydrogcnatc Castor Oil, [Emulsifier], Cocamidopropyl Betaine,[Surfactant], Citric Acid, [Acidifier], Sodium Gluconate,[Surfactant], Didecyldimonium Chloride [Preservative/Anti-bacterial Agent], Alkyl Glucoside, [Surfactant], Sodium Hydroxide, [Buffer], Sodium Chloride,[Salt] Glycerine, [Lubricant], Isopropanol,[Solvent], Polydimethylsiloxane, [Lubricant, Coatings], synthetic bees wax,[Wax], dodecyl benzene sulphonate, [Surfactant], sodium citrate, [Acidifier], Diethylcnctriaminc pcnta(methylcnc phosphonic acid), [Chelating Agent] and dialkly ammonium methosulphate, [Surfactant], Coconut fatty acid [Surfactant] at concentrations less than 1.3%, Alkyl Sulphates [Surfactant] at concentrations less than 1.3% or Alkyl Polyglucosides [Surfactant] at concentrations lcss than 1.3%; c) optionally selecting a low allergen fragrance composition.23. The method according to claim 22 further comprising the step of producing and packaging the cleaning product.24. A low allergen cleaning product as described herein with reference to the examples and Figures.25. A method of making a low allergen cleaning product as deseribcd herein with reference to the examples and Figures.