GB2496687A - Tetrahydrocannabivarin (THCV) in the protection of pancreatic islet cells - Google Patents

Tetrahydrocannabivarin (THCV) in the protection of pancreatic islet cells Download PDF

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Publication number
GB2496687A
GB2496687A GB1120066.4A GB201120066A GB2496687A GB 2496687 A GB2496687 A GB 2496687A GB 201120066 A GB201120066 A GB 201120066A GB 2496687 A GB2496687 A GB 2496687A
Authority
GB
United Kingdom
Prior art keywords
text
thcv
phytocannabinoid
diabetes
tetrahydrocannabivarin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB1120066.4A
Other languages
English (en)
Other versions
GB201120066D0 (en
Inventor
Michael Cawthorne
Colin Stott
Stephen Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GW Pharma Ltd
Original Assignee
GW Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GW Pharma Ltd filed Critical GW Pharma Ltd
Priority to GB1120066.4A priority Critical patent/GB2496687A/en
Publication of GB201120066D0 publication Critical patent/GB201120066D0/en
Priority to DK12795839.5T priority patent/DK2782568T3/en
Priority to AU2013201809A priority patent/AU2013201809B2/en
Priority to ES12795839.5T priority patent/ES2560835T3/es
Priority to PT127958395T priority patent/PT2782568E/pt
Priority to ES15185536T priority patent/ES2714350T3/es
Priority to EP15185536.8A priority patent/EP3028697B1/en
Priority to CN201280057131.2A priority patent/CN103945841A/zh
Priority to CA 2856102 priority patent/CA2856102A1/en
Priority to EP12795839.5A priority patent/EP2782568B1/en
Priority to PL12795839T priority patent/PL2782568T3/pl
Priority to GB1220874.0A priority patent/GB2496761A/en
Priority to JP2014541761A priority patent/JP6338531B2/ja
Priority to MX2014006057A priority patent/MX348564B/es
Priority to PCT/GB2012/052869 priority patent/WO2013076471A1/en
Priority to BR112014012159A priority patent/BR112014012159A2/pt
Publication of GB2496687A publication Critical patent/GB2496687A/en
Priority to US14/358,861 priority patent/US20160243075A2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/348—Cannabaceae
    • A61K36/3482—Cannabis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
GB1120066.4A 2011-11-21 2011-11-21 Tetrahydrocannabivarin (THCV) in the protection of pancreatic islet cells Withdrawn GB2496687A (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
GB1120066.4A GB2496687A (en) 2011-11-21 2011-11-21 Tetrahydrocannabivarin (THCV) in the protection of pancreatic islet cells
BR112014012159A BR112014012159A2 (pt) 2011-11-21 2012-11-20 tetra-hidrocanabivarina fitocanabinóide
CA 2856102 CA2856102A1 (en) 2011-11-21 2012-11-20 Tetrahydrocannabivarin (thcv) for use in the protection of pancreatic islet cells
PL12795839T PL2782568T3 (pl) 2011-11-21 2012-11-20 Tetrahydrokannabiwaryna (thcv) do stosowania do ochrony komórek wysepek trzustkowych
ES12795839.5T ES2560835T3 (es) 2011-11-21 2012-11-20 Tetrahidrocannabivarina (THCV) para usar en la protección de células del islote pancreático
PT127958395T PT2782568E (pt) 2011-11-21 2012-11-20 Tetraidrocanabivarin (thcv) para utilização na proteção de células de ilhota pancreática
ES15185536T ES2714350T3 (es) 2011-11-21 2012-11-20 Tetrahidrocannabivarina (THCV) para uso en la protección de células del islote pancreático
EP15185536.8A EP3028697B1 (en) 2011-11-21 2012-11-20 Tetrahydrocannabivarin (thcv) for use in the protection of pancreatic islet cells
CN201280057131.2A CN103945841A (zh) 2011-11-21 2012-11-20 用于保护胰岛细胞的四氢次大麻酚(thcv)
DK12795839.5T DK2782568T3 (en) 2011-11-21 2012-11-20 TETRAHYDROCANNABIVARIN (THCV) FOR USE IN THE PROTECTION OF CELLS in the pancreatic islets
EP12795839.5A EP2782568B1 (en) 2011-11-21 2012-11-20 Tetrahydrocannabivarin (thcv) for use in the protection of pancreatic islet cells
AU2013201809A AU2013201809B2 (en) 2011-11-21 2012-11-20 Tetrahydrocannabivarin (THCV) for use in the protection of pancreatic islet cells
GB1220874.0A GB2496761A (en) 2011-11-21 2012-11-20 Tetrahydrocannabivarin for use in treating diabetes
JP2014541761A JP6338531B2 (ja) 2011-11-21 2012-11-20 膵島細胞の保護に使用するためのテトラヒドロカンナビバリン（ｔｈｃｖ）
MX2014006057A MX348564B (es) 2011-11-21 2012-11-20 Tetrahidrocannabivarina para usarse en la protección de células de los islotes pancreáticos.
PCT/GB2012/052869 WO2013076471A1 (en) 2011-11-21 2012-11-20 Tetrahydrocannabivarin (thcv) for use in the protection of pancreatic islet cells
US14/358,861 US20160243075A2 (en) 2011-11-21 2014-05-16 Tetrahydrocannabivarin (thc) for use in the protection of pancreatic islet cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1120066.4A GB2496687A (en) 2011-11-21 2011-11-21 Tetrahydrocannabivarin (THCV) in the protection of pancreatic islet cells

Publications (2)

Publication Number Publication Date
GB201120066D0 GB201120066D0 (en) 2012-01-04
GB2496687A true GB2496687A (en) 2013-05-22

Family

ID=45475480

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1120066.4A Withdrawn GB2496687A (en) 2011-11-21 2011-11-21 Tetrahydrocannabivarin (THCV) in the protection of pancreatic islet cells
GB1220874.0A Withdrawn GB2496761A (en) 2011-11-21 2012-11-20 Tetrahydrocannabivarin for use in treating diabetes

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1220874.0A Withdrawn GB2496761A (en) 2011-11-21 2012-11-20 Tetrahydrocannabivarin for use in treating diabetes

Country Status (14)

Country Link
US (1) US20160243075A2 (enExample)
EP (2) EP2782568B1 (enExample)
JP (1) JP6338531B2 (enExample)
CN (1) CN103945841A (enExample)
AU (1) AU2013201809B2 (enExample)
BR (1) BR112014012159A2 (enExample)
CA (1) CA2856102A1 (enExample)
DK (1) DK2782568T3 (enExample)
ES (2) ES2714350T3 (enExample)
GB (2) GB2496687A (enExample)
MX (1) MX348564B (enExample)
PL (1) PL2782568T3 (enExample)
PT (1) PT2782568E (enExample)
WO (1) WO2013076471A1 (enExample)

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GB2487712B (en) 2011-01-04 2015-10-28 Otsuka Pharma Co Ltd Use of the phytocannabinoid cannabidiol (CBD) in combination with a standard anti-epileptic drug (SAED) in the treatment of epilepsy
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US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
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US10774288B2 (en) 2013-09-18 2020-09-15 The Werc Shop, LLC Terpene-based compositions, processes, methodologies for creation and products thereby
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GB2530001B (en) 2014-06-17 2019-01-16 Gw Pharma Ltd Use of cannabidiol in the reduction of convulsive seizure frequency in treatment-resistant epilepsy
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US10499584B2 (en) 2016-05-27 2019-12-10 New West Genetics Industrial hemp Cannabis cultivars and seeds with stable cannabinoid profiles
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GB2450753A (en) * 2007-07-06 2009-01-07 Gw Pharma Ltd Composition comprising inverse agonist and neutral antagonist of the CB1 and / or CB2 receptor
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GB2450753A (en) * 2007-07-06 2009-01-07 Gw Pharma Ltd Composition comprising inverse agonist and neutral antagonist of the CB1 and / or CB2 receptor
WO2009093018A1 (en) * 2008-01-21 2009-07-30 Gw Pharma Limited New use for cannabinoids

Also Published As

Publication number Publication date
JP6338531B2 (ja) 2018-06-06
US20160243075A2 (en) 2016-08-25
GB201120066D0 (en) 2012-01-04
PL2782568T3 (pl) 2016-05-31
MX2014006057A (es) 2014-08-21
BR112014012159A2 (pt) 2017-05-30
EP2782568B1 (en) 2015-10-28
DK2782568T3 (en) 2016-02-08
EP2782568A1 (en) 2014-10-01
US20160015682A2 (en) 2016-01-21
US20140335208A1 (en) 2014-11-13
ES2714350T3 (es) 2019-05-28
CA2856102A1 (en) 2013-05-30
EP3028697A1 (en) 2016-06-08
EP3028697B1 (en) 2018-12-26
GB201220874D0 (en) 2013-01-02
JP2014533680A (ja) 2014-12-15
WO2013076471A1 (en) 2013-05-30
PT2782568E (pt) 2016-02-01
CN103945841A (zh) 2014-07-23
ES2560835T3 (es) 2016-02-23
GB2496761A (en) 2013-05-22
MX348564B (es) 2017-06-20
AU2013201809A1 (en) 2013-06-06
AU2013201809B2 (en) 2015-04-23

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