GB2473575B - Diagnosis of autism - Google Patents
Diagnosis of autismInfo
- Publication number
- GB2473575B GB2473575B GB1021794.1A GB201021794A GB2473575B GB 2473575 B GB2473575 B GB 2473575B GB 201021794 A GB201021794 A GB 201021794A GB 2473575 B GB2473575 B GB 2473575B
- Authority
- GB
- United Kingdom
- Prior art keywords
- autism
- diagnosis
- behavioural
- eif4e
- modulating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 206010003805 Autism Diseases 0.000 title 1
- 208000020706 Autistic disease Diseases 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 206010000117 Abnormal behaviour Diseases 0.000 abstract 2
- 101001082110 Acanthamoeba polyphaga mimivirus Eukaryotic translation initiation factor 4E homolog Proteins 0.000 abstract 1
- 101001082109 Danio rerio Eukaryotic translation initiation factor 4E-1B Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003596 drug target Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The present invention concerns the identification of a novel drug target for use in the treatment of behavioural dis order, hi particular, the invention provides compounds capable of modulating the expression, function and/or activity of eIF4E, for use in treating a behavioural disorder as well as methods of identifying the same.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0809821.2A GB0809821D0 (en) | 2008-05-30 | 2008-05-30 | Treatment and diagnosis of behavioural disorders |
PCT/GB2009/001367 WO2009144480A1 (en) | 2008-05-30 | 2009-05-29 | Treatment and diagnosis of behavioural disorders |
Publications (3)
Publication Number | Publication Date |
---|---|
GB201021794D0 GB201021794D0 (en) | 2011-02-02 |
GB2473575A GB2473575A (en) | 2011-03-16 |
GB2473575B true GB2473575B (en) | 2013-02-20 |
Family
ID=39637839
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GBGB0809821.2A Ceased GB0809821D0 (en) | 2008-05-30 | 2008-05-30 | Treatment and diagnosis of behavioural disorders |
GB1021794.1A Expired - Fee Related GB2473575B (en) | 2008-05-30 | 2009-05-29 | Diagnosis of autism |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GBGB0809821.2A Ceased GB0809821D0 (en) | 2008-05-30 | 2008-05-30 | Treatment and diagnosis of behavioural disorders |
Country Status (2)
Country | Link |
---|---|
GB (2) | GB0809821D0 (en) |
WO (1) | WO2009144480A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013503646A (en) | 2009-09-08 | 2013-02-04 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | Compositions and methods for diagnosing autism spectrum disorders |
WO2016196324A1 (en) | 2015-05-29 | 2016-12-08 | University Of Floridia Research Foundation, Inc. | Methods for diagnosing huntington's disease |
EP3440100A4 (en) | 2016-04-04 | 2020-01-22 | University of Florida Research Foundation, Incorporated | Manipulation of eif3 to modulate repeat associated non-atg (ran) translation |
CA3060250A1 (en) | 2017-04-17 | 2018-10-25 | University Of Florida Research Foundation, Incorporated | Regulation of ran protein translation by pkr and eif2a-p pathways |
US11903910B2 (en) | 2017-09-26 | 2024-02-20 | University Of Florida Research Foundation, Incorporated | Use of metformin and analogs thereof to reduce RAN protein levels in the treatment of neurological disorders |
US20240052004A1 (en) * | 2019-10-04 | 2024-02-15 | Yale University | Targeting cap-dependent translation to reduce seizures in mtor disorders |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007094755A2 (en) * | 2005-02-04 | 2007-08-23 | Massachusetts Institute Of Technology | Compositions and methods for modulating cognitive function |
-
2008
- 2008-05-30 GB GBGB0809821.2A patent/GB0809821D0/en not_active Ceased
-
2009
- 2009-05-29 GB GB1021794.1A patent/GB2473575B/en not_active Expired - Fee Related
- 2009-05-29 WO PCT/GB2009/001367 patent/WO2009144480A1/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007094755A2 (en) * | 2005-02-04 | 2007-08-23 | Massachusetts Institute Of Technology | Compositions and methods for modulating cognitive function |
Non-Patent Citations (6)
Title |
---|
Biochem. J., Vol.356, 2001, Saghir, A. N. et al., "Modifications of eukaryotic initiation factor...", pp.557-566 * |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol. 338, 2005 Ogawa et al, "A functional link between disrupted-In-Schizophrenia 1 and the eukaryotic translation initiation factor 3" , page 771-776 * |
JOURNAL OF MEDICAL GENETICS, Vol. 45, 2008, Z Miedzybrodzka et al, "Disruption of the EIF4E Gene in Non-Syndromic Autism" pages S16 * |
Mol. Cell. Biol., Vol.9, 1989, Altmann, M. et al., "Translation in Saccharomyces...", pp.4467-4472 * |
NATURE GENETICS, Vol. 34, 2003, S Jamain et al, "Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism", pages 27-29 * |
NEUROSCIENCE LETTERS, Vol. 434, 2008, Yoon et al, "The effect of MK-801 on mTOR/p70S6K and translation-related proteins in rat frontal cortex", pages 23-28 * |
Also Published As
Publication number | Publication date |
---|---|
WO2009144480A1 (en) | 2009-12-03 |
GB0809821D0 (en) | 2008-07-09 |
GB2473575A (en) | 2011-03-16 |
GB201021794D0 (en) | 2011-02-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2009044173A3 (en) | Methods of treating cancer using notch pathway inhibitors | |
UA98629C2 (en) | Compounds and methods for kinase modulation | |
WO2011038210A3 (en) | Treatment of filaggrin (flg) related diseases by modulation of flg expression and activity | |
PH12015500730A1 (en) | Inhibitors of histone demethylases | |
UA107667C2 (en) | Medical compounds stimulating activity of pyruvate kinase m2, compositions on their basis and use in the treatment of cancer | |
GB2473575B (en) | Diagnosis of autism | |
AU2011328009A8 (en) | Compounds and methods for treating pain | |
TW200714283A (en) | Method and composition for treating peripheral vascular diseases | |
EP4295912A3 (en) | Compounds and methods for kinase modulation, and indications therefor | |
MX2015006939A (en) | Treatment of cancer with heterocyclic inhibitors of glutaminase. | |
WO2014035140A3 (en) | Compounds and compositions for modulating histone methyltransferase activity | |
TN2011000176A1 (en) | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral or non-oral antidiabetic drug | |
MX2012003770A (en) | Methods for modulation of autophagy through the modulation of autophagy-enhancing gene products. | |
EA201201650A1 (en) | HUMAN BINDING MOLECULES THAT HAVE KILLING ACTIVITY AGAINST STAFILOCCUS AND THEIR APPLICATION | |
MX2012000034A (en) | Methods for treating or preventing fatigue. | |
WO2010034015A3 (en) | Modulating the alternative complement pathway | |
UY33276A (en) | AMINO-OXAZINES AND AMINO-DIHYDROTIAZINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | |
BRPI0909447A2 (en) | Composition, methods for treating a human or animal subject in need of such treatment and for killing or inhibiting the growth of susceptible microorganisms, and use of a composition. | |
NZ703411A (en) | Use of markers in the diagnosis and treatment of prostate cancer | |
MY155340A (en) | Use of cathepsin c | |
MX2010000956A (en) | Compounds which inhibit beta-secretase activity and methods of use thereof. | |
BRPI0920170A2 (en) | methods for decreasing the amount of small, dense ldl particles and blood triglyceride and ldl levels in a human, and for identifying a candidate individual for treatment with a compound or salt, prodrug or isomer thereof, compound or salt, prodrug or isomer thereof, and method. | |
WO2011097522A3 (en) | Combination methods for treatment of disease | |
MX2009009693A (en) | Methods of activating irs-1 and akt. | |
WO2009023846A3 (en) | Methods for heat shock protein dependent cancer treatment |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20150529 |