GB2447665A - Complete cryo encapsualtion device for biological specimen vials - Google Patents
Complete cryo encapsualtion device for biological specimen vials Download PDFInfo
- Publication number
- GB2447665A GB2447665A GB0705291A GB0705291A GB2447665A GB 2447665 A GB2447665 A GB 2447665A GB 0705291 A GB0705291 A GB 0705291A GB 0705291 A GB0705291 A GB 0705291A GB 2447665 A GB2447665 A GB 2447665A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sandwich
- unit according
- complete
- cryo
- encapsualtion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000005538 encapsulation Methods 0.000 claims abstract description 11
- 239000002826 coolant Substances 0.000 claims abstract description 6
- 239000002991 molded plastic Substances 0.000 claims description 2
- 239000012472 biological sample Substances 0.000 abstract description 3
- 239000000463 material Substances 0.000 description 5
- 238000010257 thawing Methods 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- -1 Antibodies Substances 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D71/00—Bundles of articles held together by packaging elements for convenience of storage or transport, e.g. portable segregating carrier for plural receptacles such as beer cans or pop bottles; Bales of material
- B65D71/70—Trays provided with projections or recesses in order to assemble multiple articles, e.g. intermediate elements for stacking
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/02—Internal fittings
- B65D25/10—Devices to locate articles in containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D21/00—Nestable, stackable or joinable containers; Containers of variable capacity
- B65D21/02—Containers specially shaped, or provided with fittings or attachments, to facilitate nesting, stacking, or joining together
- B65D21/0209—Containers specially shaped, or provided with fittings or attachments, to facilitate nesting, stacking, or joining together stackable or joined together one-upon-the-other in the upright or upside-down position
- B65D21/0217—Containers with a closure presenting stacking elements
- B65D21/0223—Containers with a closure presenting stacking elements the closure and the bottom presenting local co-operating elements, e.g. projections and recesses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D43/00—Lids or covers for rigid or semi-rigid containers
- B65D43/14—Non-removable lids or covers
- B65D43/16—Non-removable lids or covers hinged for upward or downward movement
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/02—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/02—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage
- B65D81/05—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
- B65D85/30—Containers, packaging elements or packages, specially adapted for particular articles or materials for articles particularly sensitive to damage by shock or pressure
- B65D85/42—Containers, packaging elements or packages, specially adapted for particular articles or materials for articles particularly sensitive to damage by shock or pressure for ampoules; for lamp bulbs; for electronic valves or tubes
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
A sandwich unit 1 containing a cooling agent which is hinged at one end 2 and lockable at the other 3,4. The internal faces of each sandwich contain encapsulation spaces 5 to maintain the biological sample vials at low temperature. The top of the device has recesses 6 and the bottom legs 7 located so as to make the device stackable. Each half of the sandwich may contain a cooling agent.
Description
Complete Cryo -Encapsulation Device for Biological Specimen Vials.
This invention relates to a device for protecting biological sample vials and their contents from thawing when removed from freezer storage or for protection from thawing during transportation.
Current freezer storage facilities for a range of biological samples (i.e. Antibodies, Antigens, Recombinant Proteins, Oligonucleotides, Purified Proteins, Medical and Pathological samples) employ a variety of commercially available specimen vials placed in rack style systems. Upon removal from the freezer environment (i.e. For sample removal I stock checking purposes) these samples are exposed to the ambient temperature of the surrounding environment which is generally room temperature. Many of these samples are of high commercial / medical or academic value and can be seriously damaged in terms of biological viability when exposed to freeze / thaw cycles.
The transportation of such materials in the correct temperature environment is important both from a commercial and functionality point of view in the Biotechnology indushy, for the health sector and for the sharing of academically valuable specimens. The current system of transportation involves the use of conunercially available frozen ice packs containing water or gel as a cooling agent. The samples are generally shipped in a polystyrene outer box with a number of these ice packs loosely surrounding the material to be protected.
In both of the above cases (Storage and Transportation) the material is poorly protected from the possibility of freeze -thawing and thus to potential damage.
To overcome this the present invention proposes a molded plastic sandwich unit which is hinged at one end allowing the two halves of the device to separate. Each half of the device being filled with a cooling agent. Within the internal halves of each unit are one or more spaces (Encapsulation spaces) which can be generic or molded to fit the size and style of the particular vial to be stored or transported (i.e. micro centrifuge -vials). The device is locked in place by a clip at the opposite end of the device.
The device will therefore ensure that the material inside can be removed from storage without being immediately exposed to the surrounding ambient temperature.
The device can then be opened and closed to allow access to the contents again with a minimum of exposure to the surrounding ambient temperature.
Material can be shipped through commercial means in complete frozen encapsulation.
The individual device being transported in a polystyrene insulating outer.
The invention will now be described solely by the way of example and with reference to the accompanying drawings in which: Figure 1 shows a see through side view of the encapsulation device in the partially opened configuration.
Figure 2 shows a top view of the encapsulation device in the fully opened configuration looking onto the internal surfaces.
Figure 3 shows the top of the encapsulation device in the closed configuration.
Figure 4 shows the bottom of the encapsulation device in the closed configuration.
Figures 1 and 2 demonstrate the cryo-encapsulation device which includes two sandwich sections 1 containing a cooling agent. The device is hinged at one end 2 to allow complete one hundred and eighty degree opening of the unit The corresponding end has a hinged locking clip on the bottom section 3 with a locking recess on the top section 4 to allow the device to be completely sealed. Within each sandwich half are reciprocal encapsulatjon spaces 5 located in order to receive the particular specimen vial to be maintained at low temperature.
Figure 3 shows the top of the device in the closed configuration with recesses 6 which are located so as to receive the corresponding legs 7 of another unit.
Figure 4 shows the bottom of the device in the closed configuration with legs 7 which are located so as to insert into the recesses 6 on the top of another device thus allowing each unit to be stackable.
Claims (6)
- Claims 1. A molded plastic sandwich unit with internal surfacescontaining one or more complete encapsulasion spaces for the storage or transportation of temperature sensitive biological components in their associated storage vial or vials.
- 2. A sandwich unit according to claim 1 in which the internal space of each half of the sandwich contains a cooling agent.
- 3. A sandwich unit according to claim i in which the two sides of the unit are hinged at one end and sealable at the other.
- 4. A sandwich unit according to claim 1 in which the encapsulation space is reciprocal on the opposing side of the sandwich.
- 5. A sandwich unit according to claim 4 in which the encapsulation space is generic or specific to the particular type of storage vial.
- 6. A sandwich unit according to claim 1 in which the bottom section of the unit contains sized recesses and the top section sized legs in order to make the device stackable.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0705291A GB2447665A (en) | 2007-03-19 | 2007-03-19 | Complete cryo encapsualtion device for biological specimen vials |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0705291A GB2447665A (en) | 2007-03-19 | 2007-03-19 | Complete cryo encapsualtion device for biological specimen vials |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB0705291D0 GB0705291D0 (en) | 2007-04-25 |
| GB2447665A true GB2447665A (en) | 2008-09-24 |
Family
ID=38008726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB0705291A Withdrawn GB2447665A (en) | 2007-03-19 | 2007-03-19 | Complete cryo encapsualtion device for biological specimen vials |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2447665A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103754460A (en) * | 2014-01-15 | 2014-04-30 | 浙江省海洋水产研究所 | Penicillin bottle holding box |
| CN104443715A (en) * | 2014-11-25 | 2015-03-25 | 成都威尔诺生物科技有限公司 | Reagent kit convenient to fix |
| CN104443797A (en) * | 2014-10-10 | 2015-03-25 | 安徽省地坤汽车天窗科技有限公司 | Automobile skylight transportation case |
| CN106976648A (en) * | 2017-05-17 | 2017-07-25 | 李天俊 | Electronic component packaging unit |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB722423A (en) * | 1951-09-28 | 1955-01-26 | Robinson E S & A Ltd | Improvements in or relating to packages for fragile articles |
| EP0397607A1 (en) * | 1989-04-03 | 1990-11-14 | Qts S.R.L. | Insulated and refrigerated container for transporting medicine vials together with related material |
| JPH08268437A (en) * | 1995-03-03 | 1996-10-15 | Nobuo Shiraki | Portable drug storage case |
| WO2001049574A2 (en) * | 2000-01-04 | 2001-07-12 | Thermokeep Ltd. | Temperature controlling apparatus and method |
| WO2003101861A2 (en) * | 2002-05-29 | 2003-12-11 | Centre National De La Recherche Scientifique (C.N.R.S.) | Packing container for biological products and analogous items |
-
2007
- 2007-03-19 GB GB0705291A patent/GB2447665A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB722423A (en) * | 1951-09-28 | 1955-01-26 | Robinson E S & A Ltd | Improvements in or relating to packages for fragile articles |
| EP0397607A1 (en) * | 1989-04-03 | 1990-11-14 | Qts S.R.L. | Insulated and refrigerated container for transporting medicine vials together with related material |
| JPH08268437A (en) * | 1995-03-03 | 1996-10-15 | Nobuo Shiraki | Portable drug storage case |
| WO2001049574A2 (en) * | 2000-01-04 | 2001-07-12 | Thermokeep Ltd. | Temperature controlling apparatus and method |
| WO2003101861A2 (en) * | 2002-05-29 | 2003-12-11 | Centre National De La Recherche Scientifique (C.N.R.S.) | Packing container for biological products and analogous items |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103754460A (en) * | 2014-01-15 | 2014-04-30 | 浙江省海洋水产研究所 | Penicillin bottle holding box |
| CN104443797A (en) * | 2014-10-10 | 2015-03-25 | 安徽省地坤汽车天窗科技有限公司 | Automobile skylight transportation case |
| CN104443715A (en) * | 2014-11-25 | 2015-03-25 | 成都威尔诺生物科技有限公司 | Reagent kit convenient to fix |
| CN106976648A (en) * | 2017-05-17 | 2017-07-25 | 李天俊 | Electronic component packaging unit |
Also Published As
| Publication number | Publication date |
|---|---|
| GB0705291D0 (en) | 2007-04-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |