GB2438926A - Transdermal patch - Google Patents
Transdermal patch Download PDFInfo
- Publication number
- GB2438926A GB2438926A GB0611225A GB0611225A GB2438926A GB 2438926 A GB2438926 A GB 2438926A GB 0611225 A GB0611225 A GB 0611225A GB 0611225 A GB0611225 A GB 0611225A GB 2438926 A GB2438926 A GB 2438926A
- Authority
- GB
- United Kingdom
- Prior art keywords
- patch
- patch according
- caffeine
- active ingredient
- layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A transdermal patch having caffeine as an active ingredient in an amount sufficient to raise the awareness level of the user. The patch may be in the form of a hydrogel patch or may be a multi-layer structure. The patch may also comprise an acrylated copolymer, mineral oil, sodium hydroxide, menthol or water.
Description
<p>TRANSDERMAL PATCH</p>
<p>Field of Invention</p>
<p>This invention relates to transdermal patches which may be applied to the skin of a human subject and are loaded with an active ingredient which is intended to pass across the skin into the user's bloodstream to provide a medical or other effect.</p>
<p>Background to the Invention</p>
<p>Transdermal patches are known containing nicotine and which are intended to assist the user to give up smoking.</p>
<p>US 2003152612-A discloses a multi-layer, flexible patch in which the active ingredient can be any one of a number of chemical compounds, including caffeine, and for use in reducing the incidence of human cellulite.</p>
<p>Statement of the Invention</p>
<p>According to the present invention there is provided a transdermal patch having caffeine as an active ingredient in an amount sufficient to raise the awareness level of the user.</p>
<p>Preferably the patch is a hydrogel patch, more preferably a TDDS hydrogel patch.</p>
<p>Preferably the caffeine is present in the patch in an amount of from 50 -500 mg. More preferably 100 -350 mg, most preferably 150 to 250 mg so that for instance the patch may contain about 200 mg caffeine.</p>
<p>Preferably the patch is substantially rectangular and with a surface area of from 5 -20 cm2, more preferably about 10 cm.</p>
<p>Preferably the patch further contains one or more of acrylated copolymer, mineral oil, sodium hydroxide, Polysorbate 60 and menthol.</p>
<p>Preferably the patch includes a layer holding a water-based composition including the caffeine.</p>
<p>Preferably the patch is a multi-layer structure, a first layer being a fabric layer and including the active ingredient and a second layer being a backing layer attached to said first layer. More preferable the first and second layers have adjacent adhesive surfaces.</p>
<p>The present invention also provides a transdermal patch containing caffeine as an active ingredient for use in raising the level of awareness of a human subject.</p>
<p>Furthermore, the invention provides a method of raising the awareness of a human subject comprising applying to the body of the subject a transdermal patch containing, as an active ingredient, caffeine.</p>
<p>Detailed Description of the Invention</p>
<p>Caffeine patches, having a surface are of about 10 cm2, and containing about 200mg caffeine, and also containing amounts of acrylated copolymer, mineral oil, sodium hydroxide, Polysorbate 60 and menthol, as well as water, were applied to the upper arms of about 50 test subjects. The subjects were mainly in the 16-30 age group and each was supplied with one to six patches. The subjects reported their experiences by means of responses on a questionnaire.</p>
<p>Most of the subjects reported an on average higher and longer-lasting stimulation than one of the commercially available energy drinks or one cup of coffee. Furthermore most subjects reported a significant boost in their energy level. Many subjects reported that the use on a patch cancelled out alcohol-induced sleepiness.</p>
<p>Patches in accordance with the present invention can be used in many situations,</p>
<p>example being,-</p>
<p>* late night driving to avoid microsleep * staying awake during meetings and classes * during sporting activities, especially competitions * "burning midnight oil", such as essay writing or work assignments * reaching a higher energy level during examinations and a night out Caffeine patches according to the present invention may have a multi-layered or matrix structure that allows for constant delivery speed of the active ingredient. This enables a higher dose to be used while avoiding an over-stimulation of the sympathetic nervous system.</p>
<p>The present invention may also have application in overcoming a subject's addiction to caffeine taken in one of the conventional ways, for instance in drinks of coffee, tea or other food stuffs.</p>
Claims (1)
- <p>CLAIMS</p><p>I A transdermal patch having caffeine as an active ingredient in an amount sufficient to raise the awareness level of the user.</p><p>2 A patch according to claim I and in the form of a hydrogel patch.</p><p>3 A patch according to claim 2 and in the form of a TDDS hydrogel patch.</p><p>4 A patch according to any of the preceding claims wherein the caffeine is present in an amount of from 50 -500 mg.</p><p>A patch according to claim 4 wherein the caffeine is present in an amount of from 100-350mg.</p><p>6 A patch according to claim 5 wherein the caffeine is present in an amount of from 150-250mg.</p><p>7 A patch according to claim 6 wherein the caffeine is present in an amount of about 200 mg.</p><p>8 A the patch according to any of the preceding claims which is substantially rectangular and with a surface area of from 5 -20 cm2.</p><p>9 A patch according to claim 8, wherein the surface area is about 10 cm2.</p><p>A patch according to any of the preceding claims and further containing acrylated copolymer.</p><p>11 A patch according to any of the preceding claims and further containing mineral oil.</p><p>12 A patch according to any of the preceding claims and further containing sodium hydroxide.</p><p>13 A patch according to any of the preceding claims and further containing Polysorbate 60.</p><p>14 A patch according to any of the preceding claims and further containing menthol.</p><p>A patch according to any of the preceding claims and further containing water.</p><p>16 A patch according to any of the preceding claims and in the form of a multi-layer structure.</p><p>17 A patch according to claim 16 wherein the patch comprises a first layer being a fabric layer and including the active ingredient and a second layer being a backing layer attached to said first layer.</p><p>18 A patch according to claim 17 wherein said first and second layers have adjacent adhesive surfaces.</p><p>19 A transdermal patch containing caffeine as an active ingredient for use in raising the level of awareness of a human subject.</p><p>A method of raising the awareness level of a human subject comprising applying to the body of the subject a transdermal patch containing, as an active ingredient, caffeine.</p><p>21 A transdermal patch according to claim I and substantially as described herein.</p>
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0611225A GB2438926A (en) | 2006-06-07 | 2006-06-07 | Transdermal patch |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0611225A GB2438926A (en) | 2006-06-07 | 2006-06-07 | Transdermal patch |
Publications (2)
Publication Number | Publication Date |
---|---|
GB0611225D0 GB0611225D0 (en) | 2006-07-19 |
GB2438926A true GB2438926A (en) | 2007-12-12 |
Family
ID=36745413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB0611225A Withdrawn GB2438926A (en) | 2006-06-07 | 2006-06-07 | Transdermal patch |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB2438926A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3643296A1 (en) * | 2018-10-25 | 2020-04-29 | QM Health Care & Nutrition, S.L. | Transdermal patches for use in auriculotherapy |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991003998A1 (en) * | 1989-09-14 | 1991-04-04 | Cygnus Research Corporation | Transdermal delivery device having delayed onset |
EP0563507A1 (en) * | 1992-04-01 | 1993-10-06 | Mli Acquisition Corp. Ii | Transdermal patch incorporating a polymer film incorporated with an active agent |
WO1996000072A1 (en) * | 1994-06-23 | 1996-01-04 | The Procter & Gamble Company | Treatment of nicotine craving and/or smoking withdrawal symptoms with a transdermal or transmucosal composition containing nicotine and caffeine or xanthine |
JPH1052527A (en) * | 1997-05-20 | 1998-02-24 | Toyomaru Sangyo Kk | Motor-driven shooting device for pachinko machine or the like |
US20020034554A1 (en) * | 1999-12-16 | 2002-03-21 | Tsung-Min Hsu | Dual enhancer composition for topical and transdermal drug delivery |
US20040060268A1 (en) * | 2000-09-05 | 2004-04-01 | Donaldson Company, Inc. | Polymer, polymer microfiber, polymer nanofiber and applications including filter structures |
WO2004060447A2 (en) * | 2002-12-31 | 2004-07-22 | Ultra-Sonic Technologies, L.L.C. | Transdermal delivery using encapsulated agent activated by ultrasound and/or heat |
EP1792612A2 (en) * | 2005-11-30 | 2007-06-06 | Nexagen USA LLC | Transdermal nutritional supplement delivery patch |
-
2006
- 2006-06-07 GB GB0611225A patent/GB2438926A/en not_active Withdrawn
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991003998A1 (en) * | 1989-09-14 | 1991-04-04 | Cygnus Research Corporation | Transdermal delivery device having delayed onset |
EP0563507A1 (en) * | 1992-04-01 | 1993-10-06 | Mli Acquisition Corp. Ii | Transdermal patch incorporating a polymer film incorporated with an active agent |
WO1996000072A1 (en) * | 1994-06-23 | 1996-01-04 | The Procter & Gamble Company | Treatment of nicotine craving and/or smoking withdrawal symptoms with a transdermal or transmucosal composition containing nicotine and caffeine or xanthine |
JPH1052527A (en) * | 1997-05-20 | 1998-02-24 | Toyomaru Sangyo Kk | Motor-driven shooting device for pachinko machine or the like |
US20020034554A1 (en) * | 1999-12-16 | 2002-03-21 | Tsung-Min Hsu | Dual enhancer composition for topical and transdermal drug delivery |
US20040060268A1 (en) * | 2000-09-05 | 2004-04-01 | Donaldson Company, Inc. | Polymer, polymer microfiber, polymer nanofiber and applications including filter structures |
WO2004060447A2 (en) * | 2002-12-31 | 2004-07-22 | Ultra-Sonic Technologies, L.L.C. | Transdermal delivery using encapsulated agent activated by ultrasound and/or heat |
EP1792612A2 (en) * | 2005-11-30 | 2007-06-06 | Nexagen USA LLC | Transdermal nutritional supplement delivery patch |
Non-Patent Citations (1)
Title |
---|
Dave Birner et al "Feasibility of a Transdermal Caffeine Patch" [online], 10 May 1999, Carnegie Mellon University. Available from http://rothfus.cheme.cmu.edu/tlab/bdiff/projects/cpatch1_s99/caff1_s99.PDF * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3643296A1 (en) * | 2018-10-25 | 2020-04-29 | QM Health Care & Nutrition, S.L. | Transdermal patches for use in auriculotherapy |
WO2020084182A1 (en) * | 2018-10-25 | 2020-04-30 | Qm Health Care & Nutrition, S.L. | Transdermal patches for use in auriculotherapy |
Also Published As
Publication number | Publication date |
---|---|
GB0611225D0 (en) | 2006-07-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |