GB2384779A - Method - Google Patents
Method Download PDFInfo
- Publication number
- GB2384779A GB2384779A GB0306057A GB0306057A GB2384779A GB 2384779 A GB2384779 A GB 2384779A GB 0306057 A GB0306057 A GB 0306057A GB 0306057 A GB0306057 A GB 0306057A GB 2384779 A GB2384779 A GB 2384779A
- Authority
- GB
- United Kingdom
- Prior art keywords
- proteins
- arrays
- tagged
- terminus
- domains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
The present invention relates to novel methods of producing proteins in which one or more domains are full length and correctly folded and which are each tagged at either the N- or C-terminus with one or more marker moieties and arrays containing such proteins, as well as the use of such proteins in arrays for rapid screening.
Description
(72) Inventor(s) Roland Koziowski Jonathan Michael Blackburn Michelle Anne
Mulder Mitali Samaddar (74) Agent and/or Address for Service Kilburn & Strode 20 Red Lion Street, LONDON, WC1R 4PJ, United Kingdom
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0020357A GB0020357D0 (en) | 2000-08-17 | 2000-08-17 | Method |
US24799500P | 2000-11-14 | 2000-11-14 | |
PCT/GB2001/003693 WO2002027327A2 (en) | 2000-08-17 | 2001-08-17 | Rapid profiling of the interactions between a chemical entity and proteins in a given proteome |
Publications (3)
Publication Number | Publication Date |
---|---|
GB0306057D0 GB0306057D0 (en) | 2003-04-23 |
GB2384779A true GB2384779A (en) | 2003-08-06 |
GB2384779B GB2384779B (en) | 2004-09-29 |
Family
ID=26244855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB0306057A Expired - Fee Related GB2384779B (en) | 2000-08-17 | 2001-08-17 | Method for the production of tagged proteins |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1326970A2 (en) |
JP (1) | JP2004509645A (en) |
KR (1) | KR20030043933A (en) |
CN (1) | CN1494589A (en) |
AU (1) | AU2001279948A1 (en) |
BR (1) | BR0113330A (en) |
CA (1) | CA2420415A1 (en) |
GB (1) | GB2384779B (en) |
IL (1) | IL154486A0 (en) |
WO (1) | WO2002027327A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0202018D0 (en) | 2002-01-29 | 2002-03-13 | Sense Proteomic Ltd | Tag and method |
JP2006506447A (en) * | 2002-10-25 | 2006-02-23 | センス プロテオミック リミテッド | Proteins encoded by the BLE gene and novel methods for using bleomycin family-derived antibiotics |
US20060094059A1 (en) * | 2004-09-22 | 2006-05-04 | Odyssey Thera, Inc. | Methods for identifying new drug leads and new therapeutic uses for known drugs |
GB2460717A (en) | 2008-06-11 | 2009-12-16 | Sense Proteomic Ltd | Autoantibodies for the detection of a predisposition to Lupus |
GB2478734A (en) | 2010-03-15 | 2011-09-21 | Sense Proteomic Ltd | Auto-antibody biomarkers of prostate cancer |
GB201017520D0 (en) | 2010-10-15 | 2010-12-01 | Sense Proteomic Ltd | Biomarkers |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999011777A1 (en) * | 1997-09-03 | 1999-03-11 | Biovation Limited | Methods for protein screening |
WO1999039210A1 (en) * | 1998-01-29 | 1999-08-05 | Miller, Samuel | High density arrays for proteome analysis and methods and compositions therefor |
WO1999051773A1 (en) * | 1998-04-03 | 1999-10-14 | Phylos, Inc. | Addressable protein arrays |
WO2000004382A1 (en) * | 1998-07-14 | 2000-01-27 | Zyomyx, Inc. | Arrays of proteins and methods of use thereof |
WO2000009654A2 (en) * | 1998-08-12 | 2000-02-24 | Zycos Inc. | Profiling and cataloging expressed protein tags |
WO2001004265A2 (en) * | 1999-07-12 | 2001-01-18 | Phylos, Inc. | C-terminal protein tagging |
WO2001057198A2 (en) * | 2000-01-31 | 2001-08-09 | Sense Proteomic Limited | Methods of generating protein expression arrays and the use thereof in rapid screening |
-
2001
- 2001-08-17 GB GB0306057A patent/GB2384779B/en not_active Expired - Fee Related
- 2001-08-17 AU AU2001279948A patent/AU2001279948A1/en not_active Abandoned
- 2001-08-17 CN CNA018157068A patent/CN1494589A/en active Pending
- 2001-08-17 IL IL15448601A patent/IL154486A0/en unknown
- 2001-08-17 CA CA002420415A patent/CA2420415A1/en not_active Abandoned
- 2001-08-17 JP JP2002530855A patent/JP2004509645A/en active Pending
- 2001-08-17 WO PCT/GB2001/003693 patent/WO2002027327A2/en active Application Filing
- 2001-08-17 KR KR10-2003-7002339A patent/KR20030043933A/en not_active Application Discontinuation
- 2001-08-17 EP EP01958221A patent/EP1326970A2/en not_active Withdrawn
- 2001-08-17 BR BR0113330-6A patent/BR0113330A/en not_active IP Right Cessation
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999011777A1 (en) * | 1997-09-03 | 1999-03-11 | Biovation Limited | Methods for protein screening |
WO1999039210A1 (en) * | 1998-01-29 | 1999-08-05 | Miller, Samuel | High density arrays for proteome analysis and methods and compositions therefor |
WO1999051773A1 (en) * | 1998-04-03 | 1999-10-14 | Phylos, Inc. | Addressable protein arrays |
WO2000004382A1 (en) * | 1998-07-14 | 2000-01-27 | Zyomyx, Inc. | Arrays of proteins and methods of use thereof |
WO2000009654A2 (en) * | 1998-08-12 | 2000-02-24 | Zycos Inc. | Profiling and cataloging expressed protein tags |
WO2001004265A2 (en) * | 1999-07-12 | 2001-01-18 | Phylos, Inc. | C-terminal protein tagging |
WO2001057198A2 (en) * | 2000-01-31 | 2001-08-09 | Sense Proteomic Limited | Methods of generating protein expression arrays and the use thereof in rapid screening |
Non-Patent Citations (3)
Title |
---|
Chemistry & Biology, Vol. 8, No. 10, October 2001, pages 951-965 * |
Nature, Vol 405, No. 6788, June 2000, pages 837-846 * |
Physiological Genomics, Vol. 1, No. 1, 1999, pages 25-32 * |
Also Published As
Publication number | Publication date |
---|---|
EP1326970A2 (en) | 2003-07-16 |
WO2002027327A2 (en) | 2002-04-04 |
GB0306057D0 (en) | 2003-04-23 |
KR20030043933A (en) | 2003-06-02 |
CN1494589A (en) | 2004-05-05 |
CA2420415A1 (en) | 2002-04-04 |
WO2002027327A3 (en) | 2003-04-17 |
IL154486A0 (en) | 2003-09-17 |
JP2004509645A (en) | 2004-04-02 |
GB2384779B (en) | 2004-09-29 |
BR0113330A (en) | 2003-12-30 |
AU2001279948A1 (en) | 2002-04-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
732E | Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977) | ||
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20130817 |