GB2378693A - Capsules for medicaments, beverages, food colourings and flavours - Google Patents

Capsules for medicaments, beverages, food colourings and flavours Download PDF

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Publication number
GB2378693A
GB2378693A GB0114759A GB0114759A GB2378693A GB 2378693 A GB2378693 A GB 2378693A GB 0114759 A GB0114759 A GB 0114759A GB 0114759 A GB0114759 A GB 0114759A GB 2378693 A GB2378693 A GB 2378693A
Authority
GB
United Kingdom
Prior art keywords
capsules
gellucire
beverages
food
polyethylene glycol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0114759A
Other versions
GB0114759D0 (en
Inventor
Gursharan Moonga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to GB0114759A priority Critical patent/GB2378693A/en
Publication of GB0114759D0 publication Critical patent/GB0114759D0/en
Publication of GB2378693A publication Critical patent/GB2378693A/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0097—Dye preparations of special physical nature; Tablets, films, extrusion, microcapsules, sheets, pads, bags with dyes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00—Tea; Tea substitutes; Preparations thereof
    • A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F5/00—Coffee; Coffee substitutes; Preparations thereof
    • A23F5/24—Extraction of coffee; Coffee extracts; Making instant coffee
    • A23F5/243—Liquid, semi-liquid or non-dried semi-solid coffee extract preparations; Coffee gels; Liquid coffee in solid capsules
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
    • A23L27/72—Encapsulation
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/40—Colouring or decolouring of foods
    • A23L5/42—Addition of dyes or pigments, e.g. in combination with optical brighteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C2210/00—Physical treatment of dairy products
    • A23C2210/40—Microencapsulation; Encapsulation of particles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to the delivery of food colorings, flavors, beverages or medicaments in compositions encapsulated in one-piece soft gel capsules. The capsules shell may rupture in contact with warm drink/water over temperature of 26 degrees centigrade and the contents are released immediately or prolonged to achieve desired effects. The capsules may serve to slowly release their contents. The invention offers better consumer convenience and accuracy of the dosage for beverages, flavors or colorings. The carrier material may be polyethylene glycol 400, glycerol esters of fatty acids or gum acacia and the delivered ingredient may be caffeine, tea, coffee, cardamom, capsicum, cinnamon or medicaments, such as analgesics, NSAID, cough medicines and cardiovascular pharmaceuticals.

Description

<Desc/Clms Page number 1>
METHODS AND COMPOSITIONS OF DELIVERY SYSTEMS FOR MEDICAMENTS, BEVERAGES, FOOD COLOURINGS & FLAVOURS Dr Gursharan S. Moonga, BritHealth Ltd, Business & Technology Centre, Bessemer Drive, Stevenage, Herts., SGl 2DX England Patent Application No. GB 9919323. 7 Filing Date 17"'August 1999 ABSTRACT: The invention relates to the one-piece soft gel capsules and compositions of delivery systems for delivery of medicaments and nutrition substances for absorption in the body through gastrointestinal tract for prolonged action. The other aspect of the invention relates to the delivery of food colorings, flavors and beverages in compositions encapsulated in one-piece soft gel capsules, which can be delivered directly to prepare drinks and foods. The capsules shell ruptures in contact with warm drink/water over temperature of 26 degree centigrade and the contents are released immediately or prolonged to achieve desired effects. The invention offers better consumer convenience and accuracy of the dosage for beverages, flavors or colorings The invention also offers methods for delivery of flavors of over prolonged periods. The invention offers opportunity for pharmaceutical, beverages, foods and flavor industry to formulate new products for consumer's convenience and accurate delivery of the active substance.
BACKGROUND TO THE INVENTION Generally oral administered drug dosage forms include elixirs or drugs in liquid, tablet or hard gelatin capsules containing unit dosage of selected drug requiring dosage of two or three times per day. The slow release enables the drug to be released over an extended period while maintaining sufficient bioavailability. The slow release dosage forms have been used for hard gelatin capsules having enteric-coated pellets therein or compressed into tablets and coated from the outside.
In case of flavors no patent is published to the knowledge of the inventor regarding prolonged release in foods. A Canadian patent No. 888683 relates to Seamless Elastic Gelatin capsule (SEG) dosage form in which the fill material when in contact with water or gastric juice forms micro porous spongy substance, which diffuses the active.
Although the sustained release drug form disclosed in the patent relates to a possible system, there is need and further interest in modified release systems those can be encapsulated in one-piece soft gel capsules. These formulations should deliver the active substance under variable conditions of physiology or environment A US patent dated January 1989 Number 4,800, 083 by Food S etal used fill material of a masticator gum/elastomer having medicament dispersed in the matrix and the active substance absorbed by the body. The system is highly insoluble and mechanism for release was suggested as peristaltic movement in the gastrointestinal tract.

Claims (8)

  1. CLAIMS The inventor claims ; 1. The methods and compositions of delivery systems for beverages, food colorings and flavors. The active substances are encapsulated in one-piece soft gel capsules and the contents are released in contact with warm water/aq medium of the food or drink. The active substances examined included food colorings, flavors and beverages approved under EEC directive 98.
  2. 2. The delivery of flavors over extended period by incorporation of one of the followings ; gum acacia, guar gum, chitosan, Gellucire 53/10 (from Gattefose), Methyl cellulose mixed with Gellucire 33/01 and Polyethylene Glycol 400
  3. 3. The method and composition of delivery systems of drug substances to give prolonged desired effects. The composition included Chitosan or gum acacia or guar gum or Gellucire 53/10 or Glyceryl behenate (from Gattefosse. The active substances examined included Analgesics, NSAID, Cough medicines, and Cardiovascular drugs and some examples include Ibuprofen, Nifedipine, Naproxen, Ketoprofen, theophylene, Cimetidine, Indomethacin and vitamin C etc.
    The other systems examined included Polyethylene Glycols-Drug substance conjugates suspended in Gellucire 33/01.
    The viscosity of the formulation was adjusted using triethyl citrate or castor oil or glycerin for encapsulation in soft gel one-piece capsules. The capsules were coated with pH sensitive polymethacrylic/acrylic co-polymers in case of insulin and calcitonin capsules. Pectinate was another material examined for coating of such capsules containing peptide drug substances. The capsules showed delivery of peptides and provided protection in the gut against biological and chemical degradation.
  4. 4. The use of Eudragit E polymer, Gellucire 33/01 and Polyethylene Glycol 400 for taste and odor masking of drug substances.
  5. 5. The composition of Tea capsules :
    INGREDIENTS PER CAPSULE Polyethylene Glycol 400 25mg Gellucire 33/01 20mg Caffeine 20mg Cardamom extract Img Tea colour/flavour, 0.5mg Cinnamon extract 0.5mg Gelatin 54mg Glycerin 25mg Water 8mg The flavor and extracts can be varied to prepare any herbal or other nutritional beverage in capsule form which will dissolve immediately in contact with warm aqueous medium.
  6. 6. The composition of a Coffee Capsules
    <Desc/Clms Page number 3>
    INGREDIENTS PER CAPSULE Coffee powder 100mg Polyethylene Glycol 100mg Gellucire 33/01 50mg Gum acacia 5mg Gelatin 100mg Glycerin 50mg Water 15mg The concentration or dosage of the coffee can be varied in proportion with other ingredients for encapsulation in soft gel capsules. The capsules dissolved immediately in contact with warm water and releasing accurate dosage of the coffee and retained freshness/flavor.
  7. 7. The composition of a food flavor
    INGREDIENTS PER CAPSULE Cardamom Extract 2mg Polyethylene Glycol 40mg Gellucire 33/01 35mg Gum Acacia 25mg Gelatin 30mg Glycerin 20mg Water 4mg
    The cardamom extract can be replaced with any other flavor approved by EEC directive 98.
  8. 8. The composition of food coloring capsules
    INGREDIENTS PER CAPSULE Oleoresin Capsicum 20mg Polyethylene Glycol 40mg Gellucire 33/01 30mg Gelatin 24mg Glycerin 14mg Water 4mg
    4'Et..... vC. IRE. i. Q. R. c : J' : ;' Tt- M.. o.. t-k" < U
    <Desc/Clms Page number 4>
    The oleoresin capsicum can be replaced with any other coloring approved by EEC directive 98. The dosage can also be varied in proportion with other excepients.
    CONCLUSION AND DISCUSSION The invention offers opportunity to pharmaceutical industry to formulate slow release formulations in a consumers convenience dosage form in one-piece soft gel capsules, which are tamper evident. The invention opens new opportunities for delivery of peptide drugs.
    The other aspects of the invention offers opportunities to food, beverages and flavor industries to develop new products which gives consumers convenience and accuracy of the dosage for use in delivery of colorings, flavors and preparation of beverages.
GB0114759A 2001-06-16 2001-06-16 Capsules for medicaments, beverages, food colourings and flavours Withdrawn GB2378693A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0114759A GB2378693A (en) 2001-06-16 2001-06-16 Capsules for medicaments, beverages, food colourings and flavours

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0114759A GB2378693A (en) 2001-06-16 2001-06-16 Capsules for medicaments, beverages, food colourings and flavours

Publications (2)

Publication Number Publication Date
GB0114759D0 GB0114759D0 (en) 2001-08-08
GB2378693A true GB2378693A (en) 2003-02-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
GB0114759A Withdrawn GB2378693A (en) 2001-06-16 2001-06-16 Capsules for medicaments, beverages, food colourings and flavours

Country Status (1)

Country Link
GB (1) GB2378693A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110305779A1 (en) * 2010-06-10 2011-12-15 Cowan Fred M Phytochemical combinations that regulate pathological immunity
US8092839B2 (en) * 2004-12-13 2012-01-10 Swing Aerobics Licensing, Inc. Medicament for treatment of cancer and other diseases
US20130064956A1 (en) * 2011-09-09 2013-03-14 Bary Lyn Zeller Shelf Stable, Brewed Beverage Concentrates And Methods Of Making The Same
US8431165B2 (en) 2004-12-13 2013-04-30 Swing Aerobics Licensing, Inc. Medicament for treatment of cancer and other diseases
US8974848B1 (en) * 2008-06-26 2015-03-10 Barry W. Carothers Ingestible product and method for enhancing the appearance and quality of teeth in-vivo
WO2019141204A1 (en) * 2018-01-17 2019-07-25 Nano And Advanced Materials Institute Limited Nano-crystallized herbal ingredient-containing package and method of preparing herbal decoction
EP3556219A1 (en) * 2018-04-13 2019-10-23 Markus Traxler Syrup for enhancing hot beverages to turn them into fitness drinks
US10863754B2 (en) 2014-07-03 2020-12-15 Kraft Foods Group Brands Llc Low water coffee and tea beverage concentrates and methods for making the same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2407720A1 (en) * 1977-11-08 1979-06-01 Lipha Lyonnaise Indle Pharmace Oral sustained-action capsule formulations - of drug and excipient which swells in contact with digestive juices
EP0243930A1 (en) * 1986-05-01 1987-11-04 Pharmacaps, Inc. Gelatin-encapsulated controlled-release composition
EP0496705A1 (en) * 1991-01-24 1992-07-29 Emil Flachsmann AG Composition especially adapted for encapsulation in a solid shell and process for preparing same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2407720A1 (en) * 1977-11-08 1979-06-01 Lipha Lyonnaise Indle Pharmace Oral sustained-action capsule formulations - of drug and excipient which swells in contact with digestive juices
EP0243930A1 (en) * 1986-05-01 1987-11-04 Pharmacaps, Inc. Gelatin-encapsulated controlled-release composition
EP0496705A1 (en) * 1991-01-24 1992-07-29 Emil Flachsmann AG Composition especially adapted for encapsulation in a solid shell and process for preparing same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Abstracts of JP 61058537 A (R.P Siila KK) *
Abstracts of JP 7242536 A (Toyo Capsule KK) *
Abstracts of JP 9157162 A (Sato Pharma) *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8092839B2 (en) * 2004-12-13 2012-01-10 Swing Aerobics Licensing, Inc. Medicament for treatment of cancer and other diseases
US8431165B2 (en) 2004-12-13 2013-04-30 Swing Aerobics Licensing, Inc. Medicament for treatment of cancer and other diseases
US8974848B1 (en) * 2008-06-26 2015-03-10 Barry W. Carothers Ingestible product and method for enhancing the appearance and quality of teeth in-vivo
US20110305779A1 (en) * 2010-06-10 2011-12-15 Cowan Fred M Phytochemical combinations that regulate pathological immunity
US20130064956A1 (en) * 2011-09-09 2013-03-14 Bary Lyn Zeller Shelf Stable, Brewed Beverage Concentrates And Methods Of Making The Same
CN103917100A (en) * 2011-09-09 2014-07-09 卡夫食品集团品牌有限责任公司 Shelf stable, brewed beverage concentrates and methods of making the same
US9277758B2 (en) * 2011-09-09 2016-03-08 Kraft Foods Group Brands Llc Liquid coffee beverage concentrate
US10863754B2 (en) 2014-07-03 2020-12-15 Kraft Foods Group Brands Llc Low water coffee and tea beverage concentrates and methods for making the same
WO2019141204A1 (en) * 2018-01-17 2019-07-25 Nano And Advanced Materials Institute Limited Nano-crystallized herbal ingredient-containing package and method of preparing herbal decoction
EP3556219A1 (en) * 2018-04-13 2019-10-23 Markus Traxler Syrup for enhancing hot beverages to turn them into fitness drinks

Also Published As

Publication number Publication date
GB0114759D0 (en) 2001-08-08

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