FR2407720A1 - Oral sustained-action capsule formulations - of drug and excipient which swells in contact with digestive juices - Google Patents

Oral sustained-action capsule formulations - of drug and excipient which swells in contact with digestive juices

Info

Publication number
FR2407720A1
FR2407720A1 FR7733495A FR7733495A FR2407720A1 FR 2407720 A1 FR2407720 A1 FR 2407720A1 FR 7733495 A FR7733495 A FR 7733495A FR 7733495 A FR7733495 A FR 7733495A FR 2407720 A1 FR2407720 A1 FR 2407720A1
Authority
FR
France
Prior art keywords
swells
excipient
contact
drug
digestive juices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7733495A
Other languages
French (fr)
Inventor
Jean-Claude Lechevin
Jean-Noel Treilles
Francoise Merle
Maryse Belleville
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA Liyonnaise Industrielle Pharmaceutique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LIPHA Liyonnaise Industrielle Pharmaceutique filed Critical LIPHA Liyonnaise Industrielle Pharmaceutique
Priority to FR7733495A priority Critical patent/FR2407720A1/en
Publication of FR2407720A1 publication Critical patent/FR2407720A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients

Abstract

Oral compsns. with sustained activity comprising the active drug and an excipient which swells in contact with digestive juices, this being =45% w/w of the compsn., contained in hard gelatin capsules. The compsns. may contain drugs such as aspirin, nitrofurantoin and naftidrofuryl. Swelling agents include guar gum, tragacanth and hydroxypropylmethylcellulose. A preferred agent with aspirin is 40-45% w/w of hydroxy-propylmethylcellulose; for naftidrofuryl 20-25% w/w of swelling agent. Conventional additives such as lubricants and fillers may be used, e.g. magnesium stearate, lactose kaolin, colloidal silica.
FR7733495A 1977-11-08 1977-11-08 Oral sustained-action capsule formulations - of drug and excipient which swells in contact with digestive juices Withdrawn FR2407720A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7733495A FR2407720A1 (en) 1977-11-08 1977-11-08 Oral sustained-action capsule formulations - of drug and excipient which swells in contact with digestive juices

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7733495A FR2407720A1 (en) 1977-11-08 1977-11-08 Oral sustained-action capsule formulations - of drug and excipient which swells in contact with digestive juices

Publications (1)

Publication Number Publication Date
FR2407720A1 true FR2407720A1 (en) 1979-06-01

Family

ID=9197364

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7733495A Withdrawn FR2407720A1 (en) 1977-11-08 1977-11-08 Oral sustained-action capsule formulations - of drug and excipient which swells in contact with digestive juices

Country Status (1)

Country Link
FR (1) FR2407720A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4717713A (en) * 1983-10-31 1988-01-05 Research Corporation Controlled release liquid pharmaceutical
AT385200B (en) * 1986-07-22 1988-02-25 Kwizda Fa F Johann Process for the production of tablets with delayed release characteristics of medicinal substances
AT398165B (en) * 1986-06-16 1994-10-25 Procter & Gamble Pharma METHOD FOR PRODUCING A PHARMACEUTICAL CAPSULE FOR ORAL ADMINISTRATION WITH DELAYED ACTIVE SUBSTANCE RELEASE OR. COMBINED DELAYED / RAPID RELEASE OF ACTIVE SUBSTANCE
AT398166B (en) * 1986-06-16 1994-10-25 Procter & Gamble Pharma METHOD FOR PRODUCING A PHARMACEUTICAL CAPSULE FOR THE ORAL ADMINISTRATION OF NITROFURANTOIN (SALTS, HYDRATES, COMPLEXES)
GB2378693A (en) * 2001-06-16 2003-02-19 Gursharan Moonga Capsules for medicaments, beverages, food colourings and flavours
FR3070010A1 (en) * 2017-08-02 2019-02-15 Belles Feuilles METHOD AND SYSTEM FOR CONDITIONING A COMPOSITION OF DRY EXTRACTS OF PLANTS, AND COMPOSITION OF DRY EXTRACTS OF PLANTS THUS IMPLEMENTED.

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3247066A (en) * 1962-09-12 1966-04-19 Parke Davis & Co Controlled release dosage form containing water-swellable beadlet
FR1468716A (en) * 1964-06-19 1967-02-10 Ciba Geigy Process for preparing drugs in the form of beads
DE1445105A1 (en) * 1959-10-01 1969-01-09 Merck & Co Inc Process for the manufacture of a pharmaceutical carrier
US3427378A (en) * 1965-02-12 1969-02-11 American Cyanamid Co Sustained release encapsulated formula
LU61171A1 (en) * 1969-06-24 1970-08-26
US3574820A (en) * 1968-01-08 1971-04-13 Upjohn Co Medicinal dosage forms of unpolymerized thiolated gelatin with a cross-linking accelerating agent providing slowly released medication from a swollen matrix
FR2118492A5 (en) * 1970-12-19 1972-07-28 Friedrich & Kaufmann Efeka

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1445105A1 (en) * 1959-10-01 1969-01-09 Merck & Co Inc Process for the manufacture of a pharmaceutical carrier
US3247066A (en) * 1962-09-12 1966-04-19 Parke Davis & Co Controlled release dosage form containing water-swellable beadlet
FR1468716A (en) * 1964-06-19 1967-02-10 Ciba Geigy Process for preparing drugs in the form of beads
US3427378A (en) * 1965-02-12 1969-02-11 American Cyanamid Co Sustained release encapsulated formula
US3574820A (en) * 1968-01-08 1971-04-13 Upjohn Co Medicinal dosage forms of unpolymerized thiolated gelatin with a cross-linking accelerating agent providing slowly released medication from a swollen matrix
LU61171A1 (en) * 1969-06-24 1970-08-26
FR2118492A5 (en) * 1970-12-19 1972-07-28 Friedrich & Kaufmann Efeka

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4717713A (en) * 1983-10-31 1988-01-05 Research Corporation Controlled release liquid pharmaceutical
AT398165B (en) * 1986-06-16 1994-10-25 Procter & Gamble Pharma METHOD FOR PRODUCING A PHARMACEUTICAL CAPSULE FOR ORAL ADMINISTRATION WITH DELAYED ACTIVE SUBSTANCE RELEASE OR. COMBINED DELAYED / RAPID RELEASE OF ACTIVE SUBSTANCE
AT398166B (en) * 1986-06-16 1994-10-25 Procter & Gamble Pharma METHOD FOR PRODUCING A PHARMACEUTICAL CAPSULE FOR THE ORAL ADMINISTRATION OF NITROFURANTOIN (SALTS, HYDRATES, COMPLEXES)
AT385200B (en) * 1986-07-22 1988-02-25 Kwizda Fa F Johann Process for the production of tablets with delayed release characteristics of medicinal substances
GB2378693A (en) * 2001-06-16 2003-02-19 Gursharan Moonga Capsules for medicaments, beverages, food colourings and flavours
FR3070010A1 (en) * 2017-08-02 2019-02-15 Belles Feuilles METHOD AND SYSTEM FOR CONDITIONING A COMPOSITION OF DRY EXTRACTS OF PLANTS, AND COMPOSITION OF DRY EXTRACTS OF PLANTS THUS IMPLEMENTED.

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Legal Events

Date Code Title Description
ST Notification of lapse