GB2360284A - Human genome-derived single exon nucleic acid probes - Google Patents

Abstract

A spatially addressable set of such probes is provided for measuring gene expression in a sample derived from human heart, the probes comprising any one of the nucleotide sequences set out in SEQ ID NOS: 1-5202 or 5203-10283 or a complementary sequence. The set may comprise 50-20,000 probes of average length 200-500 bp and may be addressably disposed upon a substrate. At least 50% of the probes lack prokaryotic and bacteriophage vector sequence and at least 50% lack homopolymeric stretches of A or T. Each of the probes may be amplifiable using at least one common primer. Also claimed are said nucleotide sequences and peptides encoded thereby.

Description

2360284 HUMAN GENOME-DERIVED SINGLE EXON NUCLEIC ACID PROBES USEFUL FOR

ANALYSIS OF GENE EXPRESSION IN HUMAN HEART

Field of the Invention

The present invention relates to genome-derived single exon microarrays useful for verifying the expression of regions of genomic DNA predicted to encode protein. In particular, the present invention relates to unique genome- derived single exon nucleic acid probes expressed in human heart and single exon nucleic acid microarrays that include such probes.

Background of the Invention

For almost two decades following the invention of general techniques for nucleic acid sequencing, Sanger et al., Proc. Natl. Acad. Scl. USA 70 (4):1209-13 (1973); Gilbert et al., Proc. Natl. Acad. Scl. USA 70(12):3581-4 (1973), these techniques were used principally as tools to further the understanding of. proteins - known or suspected - about which a basic foundation of biological knowledge had already been built. In many cases, the cloning effort that preceded sequence identification had been both informed and directed by that antecedent biological understanding.

For example, the cloning of the T cell receptor for antigen was predicated.upon its known or suspected cell type-specific expression, by its suspected membrane association, and by the predicted assembly of its gene via T cell-specific somatic recombination. Subsequent sequenc-ing efforts at once confirmed and extended understanding of this family of proteins. Hedrick et al., Nature 308(5955):153-8 (1984).

More recently, however, the development of high 2 throughput sequencing methods and devices, in concert with large public and private undertakings to sequence the human and other genomes, has altered this investigational paradigm: today, sequence information often precedes understanding of the basic biology of the encoded protein product.

one of the approaches to large-scale sequencing is predicated upon the proposition that expressed sequences - that is, those accessible through isolation of mRNA - are of greatest initial interest. This "expressed sequence tag" (IIESTII) approach has already yielded vast amounts of sequence data (see for example Adams et al., Science 252:1651 (1991); Williamson, Drug Discov. Today 4:115 (1999)). For nucleic acids sequenced by this approach, often the only biological information that is known a prior! with any certainty is the likelihood of biologic expression itself. By virtue of the species and tissue from which the mRNA had originally been obtained, most such sequences are also annotated with the identity of the species and at least one tissue in which expression appears likely.

More recently, the pace of genomic sequencing has accelerated dramatically. When genomic DNA serves as the initial substrate for sequencing efforts, expression cannot be presumed; often the only a priori biological information about the sequence includes the species and chromosome (and perhaps chromosomal map location) of origin.

With the ever-accelerating pace of sequence accumulation by directed, EST, and genomic sequencing approaches - and in particular, with the accumulation of sequence information from multiple genera, from multiple species within genera, and from multiple individuals within a species there is an increasing need for methods that rapidly and effectively permit the functions of nucleic 3 sequences to be elucidated. And as such functional information accumulates, there is a further need for methods of storing such functional information in meaningful and useful relationship to the sequence itself; that is, there is an increasing need for means and apparatus for annotating raw sequence data with known or predicted functional information.

Although the increase in the pace of genomic sequencing is due in large part to technological changes in sequencing strategies and instrumentation, Service, Science 280:995 (1998); Pennisi, Science 283: 1822-1823 (1999), there is an important functional motivation as well.

While it was understood that the EST approach would rarely be able to yield sequence information about the noncoding portions of the genome, it now also appears the EST approach is capable of capturing only a fraction of a genomels actual expression complexity.

For example, when the C. elegans genome was fully sequenced, gene prediction algorithms identified over 19,000 potential genes, of which only 7,000 had been found by EST sequencing. C. elegans Sequencing Consortium, Science 282:2012 (1998). Analogously, the recently completed sequence of chromosome 2 of Arabidopsis predicts over 4000 genes, Lin et al., Nature, 402:761 (1999), of which only about 6% had previously been identified via EST sequencing efforts. Although the human genome has the greatest depth of EST coverage, it is still woefully short of surrendering all of its genes. One recent estimate suggests that the human genome contains more than 146,000 genes, which would at this point leave greater than half of the genes undiscovered. It is now predicted that many genes, perhaps 20 to 50%, will only be found by genomic sequencing.

There is, therefore, a need for methods that 4 permit the functional regions of genomic sequence - and most importantly, but not exclusively, regions that function to encode genes - to be identified.

Much of the coding sequence of the human genome is not homologous to known genes, making detection of open reading frames (11ORFs11) and predictions of gene function difficult. Computational methods exist for predicting coding regions in eukaryotic genomes. Gene prediction programs such as GRAIL and GRAIL II, Uberbacher et al., Proc. Natl. Acad. Scl. USA 88 (24):11261-5 (1991); Xu et al., Genet. Eng. 16:241-53 (1994); Uberbacher et al., Methods Enzymol. 266:259-81 (1996); GENEFINDER, Solovyev et al., Nucl. Acids. Res. 22:5156-63 (1994); Solovyev et al., 15mb 5:294-302 (1997); and GENESCAN, Burge et al., J. Mol.

Biol. 268:78-94 (1997), predict many putative genes without known homology or function. Such programs are known, however, to give high false positive rates. Burset et al., Genomics 34:353-367 (1996). Using a consensus obtained by a plurality of such programs is known to increase the reliability of calling exons from genomic sequence. Ansari-Lari et al., Genome Res. 8(l):29-40 (1998) Identification of functional genes from genomic data remains, however, an imperfect art. For example, in reporting the full sequence of human chromosome 21, the Chromosome 21 Mapping and Sequencing Consortium reports that prior bioinformatic estimates of human gene number may need to be revised substantially downwards. Nature 405:311-199 (2000); Reeves, Nature 405:283-284 (2000) Thus, there is a need for methods and apparatus that permit the functions of the regions identified bioinformatically - and specifically, that permit the expression of. regions predicted to encode protein - readily to be confirmed experimentally.

Recently, the development of nucleic acid microarrays has made possible the automated and highly parallel measurement of gene expression. Reviewed in Schena (ed.), DNA Microarrays: A Practical Approac (Practical Approach Series), Oxford University Press (1999) (ISBN: 0199637768); Nature Genet. 21 (1) (suppl):1 - 60 (1999); Schena (ed.), Microarray Biochip: Tools and Technolog, Eaton Publishing Company/ BioTechniques Books Division (2000) (ISBN: 1881299376).

It is common for microarrays to be derived from cDNA/EST libraries, either from those previously described in the literature, such as those from the I.M.A.G.E. consortium, Lennon et al., Genomics 33 (1):151-2 (1996), or from the construction of "problem specific,, libraries targeted at a particular biological question, R.S. Thomas et al., Cancer Res. (in press). Such microarrays by definition can measure expression only of those genes found in EST libraries, and thus have not been useful as probes for genes discovered solely by genomic sequencing.

The utility of using whole genome nucleic acid- microarrays to answer certain biological questions has been demonstrated for the yeast Saccharomyces cerevisiae. De Risi et al., Science 278:680 (1997) The vast majority of yeast nuclear genes, approximately 95% however, are single exon genes, i.e., lack introns, Lopez et al., RNA 5:1135- 1137 (199,9); Goffeau et al., Science 274:563-67 (1996), permitting coding regions more readily to be identified. Whole genome nucleic acid microarrays have not generally been used to probe gene expression from- more complex eukaryotic genomes, and in particular from those averaging more than one intron per gene.

Summary of the Invention

The present invention solves these and other 6 problems in the art by providing methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence. The present invention also provides apparatus for verifying the expression of putative genes identified within genomic sequence.

In particular, the invention provides novel genome-derived single exon nucleic acid microarrays useful for verifying the expression of putative genes identified within genomic sequence.

The present invention also provides compositions and kits for the ready production of nucleic acids identical in sequence to, or substantially identical in sequence to, probes on the genome-derived single exon microarrays of the present invention.

Accordingly, in a first aspect of the invention, there is provided a spatial ly- addres sable set of single exon nucleic acid probes for measuring gene expression in a sample derived from human heart, comprising a plurality of single exon nucleic acid probes according to any one of the nucleotide sequences set out in SEQ ID NOs: 1 - 5,202 or a complementary sequence, or a portion of such a sequence.

By plurality is meant at least two, suitably at least 20, most suitably at least 100, preferably at least 1000 and, most preferably, upto 5000.

In one embodiment of the first aspect, each of said plurality of probes is separately and addressably amplifiable.

In an alternative embodiment, each of said plurality of probes is separately and addressably isolatable from said plurality.

In a preferred embodiment, each of said plurality of probes is amplifiable using at least one common primer. Preferably, each of said plurality of probes is amplifiable 7 using a f irst and a second common primer. In yet another embodiment, said set of single exon nucleic acid probes comprises between 50 - 20, 000 probes, for example, 50 - 5000. 5 Suitably, said set of single exon nucleic acid probes comprises at least 50 - 1000 discrete single exon nucleic acid probes having a sequence as set out in any of SEQ ID NOS.: 1 - 10,283 or a complimentary sequence.. or a portion of such a sequence.

Preferably, the average length of the single exon nucleic acid probes is between 200 and 500 bp. It is preferred that the average length should be at least 200bp, suitably at least 250bp, most suitably at least 300bp, preferably at least 400bp and, most preferably, 500 bp.

In another embodiment, the single exon nucleic acid probes lack prokaryotic and bacteriophage vector sequence. It is preferred that at least 50%, suitably at least 60%, most suitably at least 70%, preferably at least 75%, more preferably at least 80, 85, 90, 95 or 99% of said single exon nucleic acid probes lack prokaryotic and bacteriophage vector sequence.

In another preferred embodiment, said single exon nucleic acid lack homopolymeric stretches of A or T. It is preferred that at least 50%, suitably at least 60%, most suitably at least 70%, preferably at least 75%, more preferably at least 80, 85, 90, 95 or 99% of said single exon nucleic acid probes lack homopolymeric stretches of A or T.

In a particularly preferred embodiment, a set of single exon nucleic acid probes in accordance with a first aspect of the invention comprises a nucleotide sequence selected from any of SEQ ID NOS. : 286, 287, 442, 871, 1029, 1280, 1597, 1619, 1694, 1715, 1721, 1848, 1935, 2119, 2233, 2893, 3003, 3003, 3149, 3403, 3471, 3513, 3607, 4102, 4164, 8 4184, 4184, 4242, 4730, 4779, 4976, 4988, 5473, 5608, 6019, 6169, 64 10, 6723, 6745, 6818, 6838, 6844, 6966, 7052, 7230, 7340, 8044, 8155, 8298, 8545, 8612, 8654, 8746, 9228, 9290, 9310, 9367, 9842, 9889, 10079 and 10091, a sequence complementary to any of said sequences, or.a portion of such a sequence.

In yet another embodiment, a set of single exon nucleic acid probes in accordance with the invention comprises a nucleotide encoding a peptide having an amino acid sequence as set out in any of SEQ ID NOS.: 10603, 10741, 11179, 11571, 11893, 11913, 11999, 12017, 12023, 12152, 12245, 12439, 12552, 13144, 13255, 13256, 13407, 13653, 13724, 13841, 14313, 14370, 14390, 14391, 14934, 15149 and 15161, or portion thereof.

Preferably, a spatiallyaddressable set of single exon nucleic acid probes in accordance with the first aspect of the invention is is addressably disposed upon a substrate.

Suitable substrates include a filter membrane which may, preferably, be nitrocellulose or nylon. The nylon may preferably, be positively-charged. other suitable substrates include glass, amorphous silicon, crystalline silicon, and plastic. Further suitable materials include polymethylacrylic, polyethylene, polypropylene, polyacrylate, polymethylmethacrylate, polyvinylchloride, polytetrafluoroethylene, polystyrene, polycarbonate, polyacetal, polysulfone, celluloseacetate, cellulosenitrate, nitrocellulose, and mixtures thereof.

In a second aspect of the invention, there is provided a microarray comprising a spatially addressable set of single exon nucleic acid probes in accordance with the first aspect of the invention.

In one embodiment, a genome-derived single-exon microarray is packaged together with such an ordered set of amplifiable probes corresponding to the probes, or one or 9 more subsets of probes, thereon. In alternative embodiments, the ordered set of amplifiable probes is packaged separately from the genome-derived single exon microarray.

In another aspect, the invention provides genome derived single exon nucleic acid probes useful for gene expression analysis, and particularly for gene expression analysis by microarray. In particular embodiments of this aspect, the present invention provides human single-exon probes that include spec if i cal ly-hybridi zable fragments of SEQ ID Nos. 5,203 10,283, wherein the fragment hybridizes at high stringency to an expressed human gene. In particular embodiments, the invention provides single exon probes comprising SEQ ID Nos. 1 - 5,202.

Accordingly, in a third aspect of the invention, there is provided a single exon nucleic acid probe for measuring human gene expression in a sample derived from human heart which is a nucleic acid molecule comprising a nucleotide sequence as set out in any of SEQ ID N0s.: 1 5,202 or a complementary sequence or a fragment thereof wherein said probe hybridizes at high stringency to a nucleic acid expressed in the human heart.

In one embodiment, a single exon nucleic acid probe in accordance with the third aspect comprises a nucleotide sequence as set out in any of SEQ ID N0s.: 5,203 - 10,283 or a complementary sequence or a fragment thereof.

In a fourth aspect of the invention, there is provided a single exon nucleic acid probe for measuring human gene expression in a sample derived from human heart which is a nucleic acid molecule having a sequence encoding a peptide comprising a peptide sequence as set out in any of SEQ ID N0s.: 10,284 - 15,322 or a complementary sequence or a fragment ther eof wherein said probe hybridizes at high stringency to a nucleic acid expressed in the human heart.

In a preferred embodiment, a single exon nucleic acid probe for measuring human gene expression in a sample derived from human heart is selected from any of SEQ ID NOS.: 286, 287, 442, 871, 1029, 1280, 1597, 1619, 1694, 1715, 1721, 1848, 1935, 2119, 2233, 2893, 3003, 3003, 3149, 3403, 3471, 3513, 3607, 4102, 4164, 4184, 4184, 4242, 4730, 4779, 4976, 4988, 5473, 5608, 6019, 6169, 6410, 6723, 6745, 6818, 6838, 6844, 6966, 7052, 7230, 7340, 8044, 8155, 8298, 8545, 8612, 8654, 8746, 9228, 9290, 9310, 9367, 9842, 9889, 10079 and 10091.

In another embodiment, a single exon nucleic acid probe for measuring human gene expression in a sample derived from human heart is selected from a nucleotide encoding a peptide, or portion thereof, as set out in any of SEQ ID NOS.: 10603, 10741, 11179, 115711 11893, 11913, 11999, 12017, 12023, 12152, 12245, 12439, 12552, 13144, 13255, 13256, 13407, 13653, 13724, 13841, 14313, 14370, 14390, 14391, 14934, 15149 and 15161.

Preferably, a single exon nucleic acid probe in accordance with the third or fourth aspects of the invention comprises between at least 15 and 50 contiguous of said SEQ ID NO:. It is preferred that the single exon nucleic acid probe comprises at least 15, suitably at least 20, more suitably at least 25 or preferably at least 50 contiguous nucleotides of said SEQ ID NO:.

In another preferred embodiment, a single exon nucleic acid probe in accordance with the third or fourth aspects of the invention is between 3kb and 25kb in length. It is preferred that said probe is no more than 3kb, suitably no more than 5kb, more suitably no more than 10kb, preferably 15kb, more preferably 20kb or, most preferably, no more than 20kb in length.

Preferably, a single exon nucleic acid probe in accordance with either the fifth or sixth aspect of the invention is DNA, preferably single-stranded DNA, RNA or PNA.

In another embodiment of either the third or fourth aspect of the invention, a single exon nucleic acid probe is detectably labeled. Suitable detectable labels include a radionuclide, a fluorescent label or a first member of a specific binding pair. Suitable fluorescent labels include dyes such as cyanine dyes, preferably Cy3 and CyS although other suitable dyes will be known to those skilled in the art.

In a particularly preferred embodiment, a single exon nucleic acid probe in accordance with either the third or fourth aspect of the invention lacks prokaryotic and bacteriophage vector sequence. In yet another embodiment, a single exon nucleic acid probe in accordance with either the third or fourth aspect of the invention lacks homopolymeric stretches of A or T.

In a fifth aspect of the invention, there is provided an amplifiable nucleic acid composition, comprising:

the single exon nucleic acid probe in accordance with either of the third or fourth aspects of the invention; and at least one nucleic acid primer; wherein said at least one primer is sufficient to prime enzymatic amplification of said probe.

In an sixth aspect of the invention, there is provided a method of measuring gene expression in a sample derived from human heart, comprising:

contacting the single exon microarray in accordance with the second aspect of the invention, with a first collection of detectably labeled nucleic acids, said first collection of nucleic acids derived from mRNA of human heart; and then measuring the label detectably bound to each probe of said microarray. 35 In a seventh aspect of the invention, there is 12 provided a method of identifying exons in a eukaryotic genome, comprising: algorithmically predicting at least one exon from genomic sequence of said eukaryote.; and then 5 detecting specific hybridization of detectably labeled nucleic acids to a single exon probe, wherein said detectably labeled nucleic acids are derived from mRNA from the heart of said eukaryote, said probe is a single exon probe having a fragment identical in sequence to, or complementary in sequence to, said predicted exon, said probe is included within a single exon microarray in accordance with the first aspect of the invention, and said fragment is selectively hybridizable at high stringency.

In a eighth aspect of the invention, there is provided a method of assigning exons to a single gene, comprising:

identifying a plurality of exons from genomic sequence in accordance with the seventh aspect of the invention; and then measuring the expression of each of said exons in a plurality of tissues and/or cell types using hybridization to single exon microarrays having a probe with said exon, wherein a common pattern of expression of said exons in said plurality of tissues and/or cell types indicates that the exons should be assigned to a single gene.

In an ninth aspect of the invention, there is provided a nucleic acid sequence as set out in any of SEQ ID NOs: 1 - 10, 283 wherein said sequence encodes a peptide.

In a tenth aspect of the invention, there is provided a peptide encoded by a sequence comprising a sequence as set out in any of SEQ ID NOs: 5, 203 10,283, or a complementary sequence or coding portion thereof.

13 In a preferred embodiment, a peptide may be encoded by a sequence comprising a sequence set out in any of SEQ ID NOS.: 1 -5, 2 02.

In a further aspect, the invention provides peptides comprising an amino acid sequence translated f rom the DNA fragments, said amino acid sequences comprising SEQ ID NOS.: 10, 283 - 15,322.

Accordingly in a eleventh aspect of the invention there is provided a peptide comprising a sequence as set out in any of SEQ ID NOs: 10,284 15,322, or fragment -thereof.

In another aspect, the invention provides means for displaying annotated sequence, and in particular, for displaying sequence annotated according to the methods and apparatus of the present invention. Further, such display can be used as a preferred graphical user interface for electronic search, query, and analysis of such annotated sequence.

Detailed Description of the Invention

Def initions As used herein, the term llmicroarrayll and phrase "nucleic acid microarrayll refer to a substrate-bound collection of plural nucleic acids, hybridization to each of the plurality of bound nucleic acids being separately detectable. The substrate can be solid or porous, planar or non-planar, unitary or distributed.

As so defined, the term llmicroarrayll and phrase "nucleic acid microarrayll include all the devices so called in Schena (ed.), DNA Microarrays: A Practical Approach (Practical Approach Series), Oxford University Press (1999) (I SBN: 0 19 9 6 3 7 7 6 8); Na twre Gene t. 2 1 (.1) (suppl). 1 - 6 0 14 (1999); and Schena (ed.), Microarray Biochip: Tools and Technology, Eaton Publishing Company/BioTechniques Books Division (2000) (ISBN: 1881299376). As so defined, the term llmicroarrayll and phrase "nucleic acid microarrayll further include substrate-bound collections of plural nucleic acids in which the nucleic acids are distributably disposed on a plurality of beads, rather than on a unitary planar substrate, as is described, inter alia, in Brenner et al., Proc. Natl. Acad. Sci. USA 97 (4):166501670 (2000) in such case, the term llmicroarrayll and phrase "nucleic acid microarrayll refer to the plurality of beads in aggregate.

As used herein with respect to a nucleic acid microarray, the term "probe" refers to the nucleic acid that is, or is intended to be, bound to the substrate; in such context, the term "target" thus refers to nucleic acid intended to be bound thereto by Watson-Crick complementarity. As used herein with respect to solution phase hybridization, the term "probe" refers to the nucleic acid of known sequence that is detectably labeled.

As used herein, the expression "probe comprising SEQ ID NO.", and variants thereof, intends a nucleic acid probe, at least a portion of which probe has either (i) the sequence directly as given in the referenced SEQ ID NO., or (ii) a sequence complementary to the sequence as given in the referenced SEQ ID NO., the choice as between sequence directly as given and complement thereof dictated by the requirement that the probe hybridize to mRNA.

As used herein, the term 11ORF11 refers to a nucleic acid sequence that, in at least one reading frame, does not possess stop codons; the term does not require that the ORF encode the entirety of a natural protein. In the absence of a consensus prediction, all six frames of an exon are examined for stop codons and the longest ORF is is selected. As used herein, the term "amplicon" refers to a PCR product amplified from human genomic DNA, containing the predicted exon. 5 As used herein the term "exon" ref ers to the consensus prediction of the various exon and gene predicting algorithms. As used herein, the term "peptide" refers to a sequence of amino acids. The sequences referred to as PEPTIDE SEQ ID NOS.: are the predicted peptide sequences that would be translated from one of the exons, or a portion thereof set out in exon SEQ ID NOS.:. The codons encoding the peptide are wholly contained within the exon.

As used herein, a "portions" of a defined nucleotide sequence or sequences can be and, preferably, are fragments unique to that sequence or to one or a combination of those sequences. A fragment unique to a nucleic acid molecule is one that is a signature for the larger nucleic acid molecule. 20 As used herein, the phrase "expression of a probe,, and its linguistic variants means that the ORF present within the probe, or its complement, is present within a target mRNA. As used herein, "stringent conditions" refers to parameters well known-to those skilled in the art. When a nucleic acid molecule is said to be hybridisable to another of a given sequence under "stringent conditions" it is meant that it is homologous to the given sequence.

As used herein, the phrase "specific binding pair" intends a pair of molecules that bind to one another with high specificity. Binding pairs are said to exhibit specific binding when they exhibit avidity of at least 107, preferably at least 108, more preferably at least 109 liters/mole. Nonlimiting examples of specific binding pairs are: antibody and antigen; biotin and avidin; and 16 biotin and streptavidin.

As used herein with respect to the visual display of annotated genomic sequence, the term "rectangle" means any geometric shape that has at least a f irst and a second border, wherein the f irst and second borders each are capable of mapping uniquely to a point of another visual object of the display.

As used herein, a 11Mondrianll means a visual display in which a single genomic sequence is annotated with predicted and experimentally confirmed functional information.

Brief Description of the Drawings

The present invention is further illustrated with reference to the following non-limiting figures and examples in which:

FIG. 1 illustrates a process for predicting functional regions from genomic sequence, confirming the functional activity of such regions. experimentally, and associating and displaying the data so obtained in meaningful and useful relationship to the original sequence data; FIG. 2 further elaborates that portion of the process schematized in FIG. 1 for predicting functional regions from genomic sequence; FIG. 3 illustrates a Mondrian visual display; FIG. 4 presents a Mondrian showing a hypothetical annotated genomic sequence; FIG. 5 is a histogram showing the distribution of ORF length and PCR products as obtained, with ORF length shown in black and PCR product length shown in dotted lines; FIG. 6 is a histogram showing the distribution, 17 among exons predicted according to the methods described, of expression as measured using simultaneous two color hybridization to a genome- derived single exon microarray. The graph shows the number of sequence- verified products that were either not expressed (1,011), expressed in one or more but not all tested tissues (11111 11911), or expressed in all tissues tested (111011); FIG. 7 is a pictorial representation of the expression of verified sequences that showed expression with signal intensity greater than 3 in at least one tissue, with: FIG. 7A showing the expression as measured by microarray hybridization in each of the 10 measured tissues, and the expression as measured llbioinformaticallyll by query of EST, NR and SwissProt databases; with FIG. 7B showing the legend for display of physicalexpression (ratio) in FIG. 7A; and with FIG. 7C showing the legend for scoring EST hits as depicted in FIG. 7A; FIG. 8 shows a comparison of normalized CY3 signal intensity for arrayed sequences that were identical to sequences in existing EST, NR and SwissProt databases or that were dissimilar (unknown), where black denotes the signal intensity for all sequence-verified products with a BLAST Expect (11E11) value of greater than le-30 (1 X 10-30) O'unknown") and a dotted line denotes sequence -veri f ied 25 spots with a BLAST expect (11E11) value of less, than le-30 (1 x 10-") (,.known"); FIG. 9 presents a Mondrian of BAC AC008172 (bases 25,000 to 130,000), containing the carbamyl phosphate synthetase gene (AF154830.1); and 30 FIG. 10 is a Mondrian of BAC A049839.

Methods and Apparatus for Predicting, Confirming. Annotating, and Displaying Functional Regions From Genomic Sequence Data 18 FIG. 1 is a f low chart illustrating in broad outline a process for predicting functional regions from genomic sequence, confirming and characterizing the functional activity of such regions experimentally, and then associating and displaying the information so obtained in meaningful and useful relationship to the original sequence data.

The initial input into process 10 of the present invention is drawn from one or more databases 100 containing genomic sequence data. Because genomic sequence is usually obtained from subgenomic fragments, the sequence data typically will be stored in a series of records corresponding to these subgenomic sequenced fragments.

Some fragments will have been catenated to form larger contiguous sequences (Ilcontigs"); others will not. A finite percentage of sequence data in the database will typically be erroneous, consisting inter alia of vector sequence. sequence created from aberrant cloning events, sequence of artificial polylinkers, and sequence that was erroneously read.

Each sequence record in database 100 will minimally contain as annotation a unique sequence identifier (accession number), and will typically be annotated further to identify the date of accession, species of origin, and depositor. Because database 100 can contain nongenomic sequence, each sequence will typically be annotated further to permit query for genomic sequence. Chromosomal origin, optionally with map location, can also be present. Data can be, and over time increasingly will be, further annotated with additional information, in part through use of the present invention, as described below. Annotation can be present within the data records, in information external to database 100 and linked to the records thereto, or through a combination of the two Databases useful as genomic sequence database 100 in the present invention include GenBank, and particularly include several divisions thereof, including the htgs (draft), NT (nucleotide, command line), and NR (nonredundant) divisions. GenBank is produced by the National Institutes of Health and is maintained by the National Center for Biotechnology Information (NCBI). Databases of genomic sequence from species other than human, such as mouse, rat, Arabidopsis, C. elegans, C. br-igsli, Drosophila, zebra fish, and other higher eukaryotic organisms will also prove useful as genomic sequence database 100.

Genomic sequence obtained by query of genomic sequence database 100 is then input into one or more processes 200 for identification of regions therein that are predicted to have a biological function as specified by the user. Such functions include, but are not limited to, encoding protein, regulating transcription, regulating message transport after transcription into mRNA, regulating message splicing after transcription into mRNA, of regulating message degradation after transcription into mRNA, and the like. Other functions include directing somatic recombination events, contributing to chromosomal stability or movement, contributing to allelic exclusion or X chromosome inactivation, and the like.

The particular genomic sequence to be input into process 200 will depend upon the function for which relevant sequence is to be identified as well as upon the approach chosen for such identification. Process step 200 can be iterated to identify different functions within a given genomic region. In such case, the input often will be different for the several iterations.

Sequences predicted to have the requisite function by process 200 are then input into process 300, where a subset of the input sequences suitable f or experimental confirmation is identified. Experimental confirmation can involve physical and/or bioinformatic assay. Where the subsequent experimental assay is bioinformatic, rather than physical, there are fewer constraints on the sequences that can be tested, and in this latter case therefore process 300 can output the entirety of the input sequence.

The subset of sequences output from process 300 is then used in process 400 for experimental verification and characterization of the function predicted in process 200, which experimental verification can, and often will, include both physical and bioinformatic assay.

Process 500 annotates the sequence data with the functional information obtained in the physical and/or bioinformatic assays of process 400. Such annotation can be done using any technique that usefully relates the functional information to the sequence, as, for example, by incorporating the functional data into the sequence data record itself, by linking records in a hierarchical or relational database, by linking to external databases, by a combination thereof, or by other means well known within the database arts. The data can even be submitted for incorporation into databases maintained by others, such as GenBank, which is maintained by NCBI.

As further noted in FIG. 1, additional annotation can be input into process 500 from external sources 600.

The annotated data is then displayed in process 800, either before, concomitantly with, or after optional storage 700 on nontransient media, such as magnetic disk, optical disc, magnetooptical disk, flash memory, or the like.

FIG. 1 shows that the experimental data output from process 400 can be used in each preceding step of 21 process 10: e.g., facilitating identification of functional sequences in process 200, facilitating identification of an experimentally suitable subset thereof in process 300, and facilitating creation of physical and/or informational substrates for, and performance of subsequent assay, of functional sequences in process 400.

Information from each step can be passed directly to the succeeding process, or stored in permanent or interim form prior to passage to the succeeding process.

often, data will be stored after each, or at least a plurality, of such process steps. Any or all process steps can be automated.

FIG. 2 further elaborates the prediction of functional sequence within genomic sequence according to process 200.

Genomic sequence database 100 is first queried 20 for genomic sequence.

The sequence required to be returned by query 20 will depend, in the first instance, upon the function to be identified.

For example, genomic sequences that function to encode protein can be identified inter alla using gene prediction approaches, comparative sequence analysis approaches, or combinations of the two. In gene prediction analysis, sequence from one genome is input into process 200 where at least one, preferably a plurality, of algorithmic methods are applied to identify putative coding regions. In comparative sequence analysis, by contrast, corresponding, e.g., syntenic, sequence from a plurality of sources, typically a plurality of species, is input into process 200, where at least one, possibly a plurality, of algorithmic methods are applied to compare the sequences and identify regions of least variability- The exact content of query 20 will also depend 22 upon the database queried. For example, if the database contains both genomic and nongenomic sequence, perhaps derived from multiple species, and the function to be determined is protein coding regions in human genomic sequence, the query will accordingly require that the sequence returned be genomic and derived from humans.

Query 20 can also incorporate criteria that compel return of sequence that meets operative requirements of the subsequent analytical method. Alternatively, or in addition, such operative criteria can be enforced in subsequent preprocess step 24.

For example, if the function sought to be identified is protein coding, query 20 can incorporate criteria that return from genomic sequence database 100 only those sequences present within contigs sufficiently long as to have obviated substantial fragmentation of any given exon among a plurality of separate sequence fragments.

Such criteria can, for example, consist of a required minimal individual penomic sequence fragment length, such as 10 kb, more typically 20 kb, 3o kb, 4okb, and preferably 50 kb or more, as well as an optional further or alternative requirement that sequence from any given clone, such as a bacterial artificial chromosome (11BACII), be presented in no more than a finite maximal number of fragments, such as no more than 20 separate pieces, more typically no more than 15 fragments, even more typically no more than about 10 - 12 fragments.

Results using the present invention have shown that genomic sequence from bacterial artificial chromosomes (BACs) is sufficient for gene prediction analysis according to the present invention if the sequence is at least 50 kb in length, and if additionally the sequence from any given BAC is presented in fewer than 15, and preferably fewer than 10, fragments. Accordingly, query 20 can incorporate 23 a requirement that data accessioned from BAC sequencing be in fewer than 15, preferably fewer than 10, fragments.

An additional criterion that can be incorporated into the query can be the date, or range of dates ' of sequence accession. Although the process has been described above as if genomic sequence database 100 were static, it is of course understood that the genomic sequence databases need not be static, and indeed are typically updated on a frequent, even hourly, basis. Thus, as further described in Examples 1 and 2, infra, it is possible to query the database for newly added sequence, either newly added after an absolute date, or newly added relative to a. prior analysis performed. using the methods and apparatus of the present invention. In this way, the process herein described can incorporate a dynamic, temporal component.

One utility of such temporal limitation is to identify, from newly accessioned genomic sequence, the presence of novel genes, particularly those not previously identified by EST sequencing (or other sequencing efforts that are similarly based upon gene expression). As further described in Example 1, such an approach has shown that newly accessioned human genomic sequence, when analyzed for sequences that function to.encode protein, readily identifies genes that are novel over those in existing EST and other expression databases. This makes the methods of the present invention extremely powerful gene discovery tools. And as would be appreciated, such gene discovery can be performed using genomic sequence from species other than human.

If query 20 incorporates multiple criteria, such as above-described, the multiple criteria can be performed as a series of separate queries or as a single query, depending in part upon the query language, the complexity 24 of the query, and other considerations well known in the database arts.

If query 20 returns no genomic sequence meeting the query criteria, the negative result can be reported by process 22, and process 200 (and indeed, entire process 10) ended 23, as shown. Alternatively, or in addition to report and termination of the initial inquiry, a new query 20 can be generated that takes into account the initial negative result.

When query 20 returns sequence meeting the query criteria, the returned sequence is then passed to optional preprocessing 24, suitable and specific for the desired analytical approach and the particular analytical methods thereof to be used in process 25.

Preprocessing 24 can include processes suitable for many approaches and methods thereof, as well as processes specifically suited for the intended subsequent analysis.

Preprocessing 24 suitable for most approaches and methods will include elimination of sequence irrelevant to, or that would interfere with. the subsequent analysis. Such sequence includes repetitive sequence, such as Alu. repeats and LINE elements, vector sequence, artificial sequence, such as artificial polylinkers, and the like.

Such removal can readily be performed by identification and subsequent masking of the undesired sequence.

Identification can be effected by comparing the genomic sequence returned by query 20 with public or private databases containing known repetitive sequence, vector sequence, artificial sequence, and other artifactual sequence. Such comparison can readily be done using programs well known in the art, such as CROSS - MATCH, or by proprietary sequence comparison programs the enginee ring of which is well within the skill in the art.

Alternatively, or in addition, undesirable, including artifactual, sequence can be identified algorithmically without comparison to external databases and thereafter removed. For example, synthetic polylinker sequence can be identified by an algorithm that identifies a significantly higher than average density of known restriction sites. As another example, vector sequence can be identified by algorithms that identify nucleotide or codon usage at variance with that of the bulk of the genomic sequence.

once identified, undesired sequence can be removed. Removal can usefully be done by masking the undesired sequence as, for example, by converting the specific nucleotide references to one that is unrecognized by the subsequent bioinformatic algorithms, such as "X".

Alternatively, but at present less preferred, the undesired sequence can be excised from the returned genomic sequence, leaving gaps.

Preprocessing 24 can further include selection from among duplicative sequences of that one sequence of highest quality. Higher quality can be measured as a lower percentage of, fewest number of, or least densely clustered occurrence of ambiguous nucleotides, defined as those nucleotides that are identified in the genomic sequence using symbols indicating ambiguity. Higher quality can also or alternatively be valued by presence in the longest contig.

Preprocessing 24 can, and often will, also include formatting of the data as specifically appropriate for passage to the analytical algorithms of process 25.

Such formatting can and typically will include, inter alla, addition of a unique sequence identifier, either derived from the original accession number in genomic sequence database 100, or newly applied, and can further include additional annotation. Formatting can include conversion 26 from one to another sequence listing standard, such as conversion to or from FASTA or the like, depending upon the input expected by the subsequent process.

Preprocessing, -which can be optional depending upon the function desired to be identified and the informational requirements of the methods for effecting such identification, is followed by sequence processing 25, where sequences with the desired function are identified within the genomic sequence.

As mentioned above, such functions can include, but are not limited to, encoding protein, regulating transcription, regulating message transport after transcription into mRNA, regulating message splicing after transcription, of regulating message degradation, and the like. Other functions include directing somatic recombination events, contributing to chromosomal stability or movement, contributing to allelic exclusion or X chromosome inactivation, or the like.

The methods of the present invention are particularly useful for gene discovery, that is, for identifying, from genomic sequence, regions that function to encode genes, and in a particularly useful embodiment, for identifying regions that function to encode genes not hitherto identified by express ion-based or directed cloning and sequencing. In conjunction with verification using the novel single exon microarrays of the present invention, as further described below, the methods herein described become powerful gene discovery tools. - Accordingly, in a preferred embodiment of the present invention, process 25 is used to identify putative coding regions. Two preferred approaches in process 25 for identifying sequence that encodes putative genes are gene prediction and comparative sequence analysis.

Gene prediction can be performed using any of a number of algorithmic methods, embodied in one or more 27 software programs, that identify open reading frames (ORFs) using a variety of heuristics, such as GRAIL, DICTION, and GENEFINDER. Comparative sequence analysis similarly can be performed using any ' of a variety of known programs that identify regions with lower sequence variability.

As further described in Example 1, below, gene finding software programs yield a range of results. For the newly accessioned human genomic sequence input in Example 1, for example, GRAIL identified the greatest percentage of genomic sequence as putative coding region, 2% of the data analyzed; GENEFINDER was second, calling 1%; and DICTION yielded the least putative coding region, with 0.8% of genomic sequence called as coding region.

Increased reliability can be obtained when consensus is required among several such methods. Although discussed herein particularly with respect to exon calling, consensus among methods will in general increase reliability of predicting other functions as well.

Thus, as indicated by query 26, sequence processing 25, optionally with preprocessing 24, can be repeated with a different method, with consensus among such iterations determined and reported in process 27.

Process 27 compares the several outputs for a given input genomic sequence and identifies consensus among the separately reported results. The consensus itself, as well as the sequence meeting that consensus, is then stored in process 29a, displayed in process 29b, and/or output to process 300 for subsequent identification of a subset thereof suitable for assay.

Multiple levels of consensus can be calculated and reported by process 27. For example, as further described in Example 1, infra, process 27 can report consensus as between all specific pairs of methods of gene prediction, as consensus among any one or more of the pairs 28 of methods of gene prediction, or as among all of the gene prediction algorithms used. Thus, in Example 1, process 27 reported that GRAIL and GENEFINDER programs agreed on 0.7% of genomic sequence, that GRAIL and DICTION agreed on 0.5% of genomic sequence, and that the three programs together agreed on 0.25% of the data analyzed. Put another way, 0.25% of the genomic sequence was identified by all three of the programs as containing putative coding region.

Furthermore, consensus can be required among 10 different approaches to identifying a chosen function.

For example, if the function desired to be identified is coding of protein sequence, and a first used approach to exon calling is gene prediction, the process can be repeated on the same input sequence, or subset thereof, with another approach, such as comparative sequence analysis. In such a case, where comparative sequence analysis follows gene prediction, the comparison can be performed not only on genomic nucleic acid sequence, but additionally or alternatively can be performed on the predicted amino acid.sequence translated from the ORPs prior identified by the gene prediction approach. Although shown as an iterative process, the multiple analyses required to achieve consensus can be done in series, in parallel, or some combination thereof. 25 Predicted functional sequence, optionally representing a consensus among a plurality of methods and approaches for determination thereof, is passed to process 300 for identification of a subset thereof for functional assay. 30 In the preferred embodiment of the methods of the present invention, wherein the function sought to be identified is protein coding, process 300 is used to identify a subset thereof suitable for experimental verification by physical and/or bioinformatic approaches. 35 For example, putative ORFs identified in process 29 can be classified, or binned, bioinformatically into putative genes. This binning can be based inter alia upon consideration of the average number of exons/gene in the species chosen for analysis, upon density of exons that have been called on the genomic sequence, and other empirical rules. Thereafter, one or more among the genespecific ORFs can be chosen for subsequent use in gene expression assay.

Where such subsequent gene expression assay uses amplified nucleic acid, considerations such as desired amplicon length, primer synthesis requirements, putative exon length, sequence GC content, existence of possible secondary structure, and the like can be used to identify and select those ORFs that appear most likely successfully to amplify. Where subsequent gene expression assay relies upon nucleic acid hybridization, whether or not using amplified product, further considerations involving hybridization stringency can be applied to identify that subset of sequences that will most readily permit sequence- specific discrimination at a chosen hybridization and wash stringency. One particular such consideration is avoidance of putative exons.that span repetitive sequence; such sequence can hybridize spuriously to nonspecific message, reducing specific signal in the hybridization. 25 For bioinformatic assay, there are fewer constraints on the sequences that can be tested experimentally, and in this latter case therefore process 300 can output the entirety of the input sequence. The subset of sequences identified by process 300 as suitable for use in assay is then used in process 400 to create the physical and/or informational substrate for experimental verification of the predictions made in process 200, and thereafter to assay those substrates.

As mentioned, the methods of the present invention are particularly useful for identifying potential coding regions within genomic sequence. In a preferred embodiment of process 400, therefore, the expression of the sequences predicted to encode protein is verified. The combination of the predictive and experimental methods provides a powerful gene discovery engine.

Thus, in another aspect, the present invention provides methods and apparatus for verifying the expression of putative genes identified within genomic sequence. In particular, the invention provides a novel method of verifying gene expression,in which expression of predicted ORFs is measured and confirmed using a novel type of nucleic acid microarray, the genome- derived single exon nucleic acid microarrays of the present invention.

Putative ORFs as predicted by a consensus of gene calling, particularly gene prediction, algorithms in process 200, and as further identified as suitable by process 300, are amplified from genomic DNA using the polymerase chain reaction (PCR). Although PCR is conveniently used, other amplification approaches can also be used..

Amplification schemes can be designed to capture the entirety of each predicted ORF in an amplicon with minimal additional (that is, intronic or intergenic) sequence. Because ORFs predicted from human genomic sequence using the methods of the present invention differ in length, such an approach results in amplicons of varying length.

However, most predicted ORFs are shorter than 500 bp in length, and although amplicons of at least about 100 or 200 base pairs can be immobilized as probes on nucleic acid microarrays, early experimental results using the methods of the present invention have suggested that longer amplicons, at least about 400 or 500 base pairs, are more effective. Furthermore, certain advantages derive from 31 application to the microarray of amplicons of defined size.

Therefore, amplification schemes can alternatively, and preferably, be designed to amplify regions of defined size, preferably at least about 300, 400 or 500 bp, centered about each predicted ORF. Such an approach results in a population of amplicons of limited size diversity, but that typically contain intronic and/or intergenic nucleic acid in addition to putative ORF.

Conversely, somewhat fewer than 10% of ORFs predicted from human genomic sequence according to the methods of the present invention exceed 500 bp in length. Portions of such extended ORFs, preferably at least about 30.0,400 or 500 bp in length, can be amplified. However, it has been discovered that the percentage success at amplifying pieces of such ORFs is low, and that such putative exons are more effectively amplified when larger fragments, at least about 1000 or 1500 bp, and even as large as 2000 bp are amplified.

The putative ORFs selected in process 300 are thus input into one or more primer design programs, such as PRIMER3 (available online for use at http://www-genome.wi.mit.edu/cgi-bin/primer/ with a goal of amplifying at least about 500 base pairs of genomic sequence centered within or about ORFs predicted to be no more than about 500 bp, or at least about 1000 1500 bp of genomic sequence for ORFs predicted to exceed 500 bp in length, and the primers synthesized by standard techniques.

Primers with the requisite sequences can be purchased commercially or synthesized by standard techniques.

Conveniently, a first predetermined sequence can be added commonly to the ORF-specific 51 primer and a second, typically different, predetermined sequence commonly added to each 31 ORF-unique primer. This serves to immortalize the amplicon, that is, serves to permit further amplification of any amplicon using a single set of 32 primers complementary respectively to the common 51 and common 31 sequence elements.. The presence of these "universal" priming sequences further facilitates later sequence verification, providing a sequence common to all amplicons at which to prime sequencing reactions. The common 51 and 31 sequences further serve to add a cloning site should any of the ORFs warrant further study.

Such predetermined sequence is usefully at least about 10, 12 or 15 nt in length, and usually does not exceed about 25 nt in length. The "univ'ersall' priming sequences used in the examples presented infra were each 16 nt long.

The genomic DNA to be used as substrate for amplification will come from the eukaryotic species from which the genomic sequence data had originally been obtained, or a closely related species, and can conveniently be prepared by well known techniques from somatic or germline tissue or cultured cells of the organism. See, e.g., Short Protocols in Molecular Biolog 20: A Compendium of Methods from Current Protocols in Molecular Biolog, Ausubel et al. (eds.), 4 h edition (April 1999), John Wiley & Sons (ISBN: 047132938X) and Maniatis et al., Molecular Cloning: A Laboratory Manual, 2 nd edition (December 1989), Cold Spring Harbor Laboratory Press (ISBN: 0879693096). Many such prepared genomic DNAs are available commercially, with the human genomic DNAs additionally having certification of donor informed consent.

Although the intronic and intergenic material flanking putative coding regions in the amplicons could potentially interfere with hybridizations during microarray experiments, we have found, surprisingly, that differential expression ratios are not significantly affected. Rather, the predominant effect of exon size is to alter the 33 absolute signal intensity, rather than its ratio. Equally surprising, the art had suggested that single exon probes would not provide sufficient signal intensity for high stringency hybridization analyses; we find that suchprobes not only provide. adequate signal, but have substantial advantages, as herein described.

After partial purification, as by size exclusion spin column, with or without confirmation as to amplicon quality as by gel electrophoresis, each amplicon (single 10 exon probe) is disposed in an array upon a support substrate.

Methods for creating microarrays by deposition and fixation of nucleic acids onto support substrates are well known in the art (Reviewed by Schena et al., see is above).

Typically, the support substrate will be glass, although other materials, such as amorphous or crystalline silicon or plastics. Such plastics include polymethylacrylic, polyethylene, polypropylene, polyacrylate, polymethylmethacrylate, polyvinylchloride, polytetrafluoroethylene, polystyrene, polycarbonate, polyacetal, polysulfone, celluloseacetate, cellulosenitrate, nitrocellulose, or mixtures thereof, can also be used. Typically, the support will be rectangular, although other shapes, particularly circular disks and even spheres, present certain advantages. Particularly advantageous alternatives to glass slides as support substrates for array of nucleic acids are optical discs, as described in WO 98/12559.

The amplified nucleic acids can be attached covalently to a surface of the support substrate or, more typically, applied to a derivatized surface in a chaotropic agent that facilitates denaturation and adherence by presumed noncovalent interactions, or some combination thereof.

34 Robotic spotting devices useful for arraying nucleic acids on support substrates can be constructed using public domain specifications (The MGuide, version 2. 0, http: //cmgm. stanf ord. edu/pbrown/mguide/ index. html) or 5 can conveniently be purchased from commercial sources (MicroArray GenII Spotter and MicroArray GenIII Spotter, Molecular Dynamics, Inc., Sunnyvale, CA). Spotting can also be effected by printing methods, including those using ink jet technology.

As is well known in the art, microarrays typically also contain immobilized control nucleic acids. For controls useful in providing measurements of background signal for the genome- derived single exon microarrays of the present invention, a plurality of E. col! genes can readily be used. As further described in Example 1, 16 or 32 E. coli genes suffice to provide a robust measure of background noise in such microarrays.

As is well known in the art, the amplified product disposed in arrays on a support substrate to create a nucleic acid microarray can consist entirely of natural nucleotides linked by phosphodiester bonds, or alternatively can include either nonnative nucleotides, alternative internucleotide linkages, or both, so long as complementary binding can be obtained in the hybridization.

If enzymatic amplification is used to produce the immobilized probes, the amplifying enzyme will impose certain further constraints upon the types of nucleic acid analogs that can be generated.

Although particularly described herein as using high density microarrays constructed on planar substrates, the methods of the present invention for confirming the expression of ORFs predicted from genomic sequence can use any of the known types of microarrays, as herein defined, including lower density planar arrays, and microarrays on nonplanar, nonunitary, distributed substrates.

For example, gene expression can be confirmed using hybridization to lower density arrays, such as those constructed on membranes, such as nitrocellulose, nylon, and pos itively- charged derivatized nylon membranes. Further, gene expression can also be confirmed using nonplanar, bead-based microarrays such as are described in Brenner et al., Proc. Matl. Acad. Sci. USA 97 (4):166501670 (2000); U. S. Patent No. 6,057, 107; and U. S. Patent No.

5,736,330. In theory, a packed collection of such beads provides in aggregate a higher density of nucleic acid probe than can be achieved with spotting or lithography techniques on a single planar substrate.

Planar microarrays on solid substrates, however, provide certain useful advantages, including high throughput and compatibility with existing readers. For example, each standard microscope slide can include at least 1000, typically at least 2000, preferably 5000 and upto 10, 000 50, 000 or more nucleic acid probes of discrete sequence. The number of sequences deposited will depend on their required application.

Each putative gene can be represented in the array by a single predicted ORF. Alternatively, genes can be represented by more than one predicted ORP. For purposes of measuring differential splicing, more than one predicted ORF will be provided f or a putative gene. And as is well known in the art, each probe of defined sequence, representing a single predicted ORF, can be deposited in a plurality of locations on a single microarray to provide redundancy of signal.

The genome-derived single exon microarrays described above differ in several fundamental and advantageous ways from microarrays presently used in the gene expression art, including (1) those created by 36 deposition of mRNA-derived nucleic acids, (2) those created by in situ synthesis of oligonucleotide probes, and (3) those constructed from yeast genomic DNA.

most nucleic acid microarrays that are in use for study of eukaryotic gene expression have as immobilized probes nucleic acids that are derived either directly or indirectly - from expressed message. As discussed above, it is common, for example, for such microarrays to be derived from cDNA/EST libraries, either from those previously described in the literature, see Lennon et al., or from the de novo construction of "problem specific,, libraries targeted at a particular biological question, R.S. Thomas et al., Cancer Res. (in press). Such microarrays are herein collectively denominated 1IEST microarrays 11.

Such EST microarrays by definition can measure expression only of those genes found in EST libraries, shown herein to represent only a fraction of expressed genes. Furthermore, such libraries - and thus microarrays based thereupon - are biased by the tissue or cell type of message origin, by the expression levels of the respective genes within the tissues, and by the ability of the message successfully to have been reverse- transcribed and cloned.

Thus, as further discussed in Example 1, the methods of the present invention enable sequences that do not appear in EST or other expression databases to be determined - subsequently arrayed for expnession measurements could not, therefore, have been represented as probes on an EST microarray. And as further demonstrated in the examples, infra, the remaining population of genes identified from genomic sequence by the methods of the present invention - that is, the one third of sequences that had previously been accessioned in EST or other expression databases - are biased toward genes with higher 37 expression levels.

Representation of a message in an EST and/or cDNA library depends upon the successful reverse transcription, optionally but typically with subsequent successful cloning, of the message. This introduces substantial bias into the population of probes available for arraying in EST microarrays.

In contrast, neither reverse transcription nor cloning is required to produce the probes arrayed on the genome-derived single exon microarrays of the present invention. And although the ultimate deposition of a probe on the genome-derived single exon microarray of the present invention depends upon a successful amplification from genomic material, a prior! knowledge of the sequence of the desired amplicon affords greater opportunity to recover any given probe sequence recalcitrant to amplification than is afforded by the requirement for successful reverse transcription and cloning of unknown message in EST approaches. 20 Thus, the genome-derived single exon microarrays of the present invention present a far greater diversity of probes for measuring gene expression, with far less bias, than do EST microarrays presently.used in the art. As a further consequence of their ultimate origin from expressed message, the probes in EST microarrays often contain poly- A (or complementary poly-T) stretches derived from the poly-A tail of mature mRNA. These homopolymeric stretches contribute to cross- hybridization, that is, to a spurious signal occasioned by hybridization to the homopolymeric tail of a labeled cDNA that lacks sequence homology to the gene-specific portion of the probe.

In contrast, the probes arrayed in the genomederived single exon microarrays of the present invention lack homopolymeric stretches derived from message 38 polyadenylation, and thus can,provide more specific signal. Typically, at least about 50, 60 or 75% of the probes on the genome-derived single exon microarrays of the present invention lack homopolymeric regions consisting of A or T, where a homopolymeric region is defined for purposes herein as stretches of 25 or more, typically 30 or more, identical nucleotides.

A further distinction, which also affects the specificity of hybridization, is occasioned by the typical derivation of EST microarray probes from cloned material. Because much of the probe material disposed as probes on EST microarrays is excised or amplified from plasmid, phage, or phagemid vectors, EST microarrays typically include a fair amount of vector sequence, more so when the probes are amplified, rather than excised, from the vector.

In contrast, the vast majority of probes in the genome-derived single exon microarrays of the present invention contain no prokaryotic or bacteriophage vector sequence, having been amplified directly or indirectly from genomic DNA. Typically, therefore, at least about 50, 60, 70 or 80% or more of individual exon-including probes disposed on a genome-derived single exon microarray of the present invention lack vector sequence, and particularly lack sequences drawn from plasmids and bacteriophage.

Preferably, at least about 85, 90 or more than 90% of exonincluding probes in the genome-derived single exon microarray of the present invention lack vector sequence. With attention to removal of vector sequences through preprocessing 24, percentages of vector-free exon- including probes can be as high as 95 - 99%. The substantial absence of vector sequence from the genome-derived single exon microarrays, of the present invention results in greater specificity during hybridization, since spurious cross hybridization to a probe vector sequence is reduced.

As a further consequence of excision or 39 amplification of probes from vectors in construction of EST microarrays, the probes arrayed thereon of ten contain artificial sequence, derived from vector polylinker multiple cloning sites, at both 5 1 and 31 ends. The probes disposed upon the genome-derived single exon microarrays need have no such artificial sequence appended thereto.

As mentioned above, however, the ORF-specific primers used to amplify putative ORFs can include artificial sequences, typically 51 to the ORFspecific primer sequence, useful for "universal" (that is, independent of ORF sequence) priming of subsequent amplification or sequencing reactions. When such "universal" 51 and/or 31 priming sequences are appended to the amplification primers, the probes disposed upon the genome-derived single exon microarray will include artificial sequence similar to that found in EST microarrays. However, the genome-derived single exon microarray of the present invention can be made without such sequences, and if so constructed, presents an even smaller amount of nonspecific sequence that would contribute to nonspecific hybridization.

Yet another consequence of typical use of cloned material as probes in EST microarrays is that such microarrays contain probes that result from cloning artifacts, such as chimeric molecules containing coding region of two separate genes. Derived from genomic material, typically not thereafter cloned, the probes of the genome-derived single exon microarrays of the present invention lack such cloning artifacts, and thus provide greater specificity of signal in gene expression measurements.

A further consequence of the cloned origin of probes on many EST microarrays is that the individual probes often have disparate sizes, which can cause the optimal hybridization stringency to vary among probes on a single microarray. In contrast, as discussed above, the probes arrayed on the genome-derived single exon microarrays of the present invention can readily be designed to have a narrow distribution in sizes, with the range of probe sizes no greater than about 10% of the average size, typically no greater than about 5% of the average probe size.

Because of their origin from fully- or partially spliced message, probes disposed upon EST arrays will often include multiple exons. The percentage of such exonspanning probes in an EST microarray can be calculated, on average, based upon the predicted number of exons/gene for the given species and the average length of the immobilized probes. For human genes, the near-complete sequence of human chromosome 22, Dunham et al., Nature 402 (6761):489-95 (1999), predicts that human genes average 5.5 exons/gene. Even with probes of 200 - 500 bp, the vast majority of human EST microarray probes include more than one exon.

In contrast, by virtue of their origin from algorithmically identified ORPs in genomic sequence, the probes in the genome-derived single exon microarrays of the present invention can consist of individual exons. Thus, in contrast to EST microarrays, at least about 50, 60, 70, 75, 80, 85, 95 or 99% of probes deposited in the genome- derived microarray of the present invention. consist of, or include, no more than one predicted ORF.

This provides the ability, not readily achieved using EST microarrays, to use the genome-derived single exon microarrays of the present invention to measure tissue-specific expression of individual exons, which in turn allows differential splicing events to be detected and characterized, and in particular, allows the correlation of differential splicing to tissuespecific expression patterns.

41 Furthermore, the exons that are represented in EST microarrays are often biased toward the 31 or 51 end of their respective genes, since sequencing strategies used for EST identification are so biased. In contrast, no such 31 or 51 bias necessarily inheres in the selection of exons for disposition on the genome-derived single exon microarrays of the present invention.

Conversely, the. probes provided on the genomederived single exon microarrays of the present invention typically, but need not necessarily, include intronic and/or intergenic sequence that is absent from EST microarrays, which are derived from mature mRNA. Typically, at least about 50, 60, 70, 80 or 90% of the exon- including probes on the genome-derived single exon microarrays of the present invention include sequence drawn from noncoding regions. As discussed above, the additional presence of noncoding region does not significantly interfere with measurement of gene expression, and provides the additional opportunity to assay prespliced RNA, and thus measure such phenomena such as nuclear export control.

The genome-derived single exon microarrays of the present invention are also quite different from in situ synthesis microarrays,. where probe size is severely constrained by inadequacies in the photolithographic synthesis process.

Typically, probes arrayed on in situ synthesis microarrays are limited to a maximum of about 25 bp. As a well known consequence, hybridization to such chips must be performed at low stringency. In order, therefore, to achieve unambiguous sequence- spec if ic hybridization results, the in situ synthesis microarray requires substantial redundancy, with concomitant programmed arraying for each probe of probe analogues with altered (i.e., mismatched) sequence.

42 In contrast, the longer probe length of the genome-derived single exon microarrays of the present invention allows much higher stringency hybridization and wash. Typically, therefore, exon-including probes on the genome-deri,ved single exon microarrays of the present invention average at least about 100, 200, 300, 400 or 500 bp in length. By obviating the need for substantial probe redundancy, this approach permits a higher density of probes for discrete exons or genes to be arrayed on the microarrays of the present invention than can be achieved for in situ synthesis microarrays.

A further distinction is that the probes in in situ synthesis microarrays typically are covalently linked to the substrate surface. In contrast, the probes disposed on the genomederived microarray of the present invention typically are, but need not necessarily be, bound noncovalently to the substrate.

Furthermore, the short probe size on in situ microarrays causes large percentage differences in the melting temperature of probes hybridized to their complementary target sequence, and thus causes large percentage differences in the theoretically optimum stringency across the array as a whole.

In contrast, the larger probe size in the microarrays of the present invention create lower percentage differences in melting temperature across the range of arrayed probes.

A further significant advantage of the microarrays of the present invention over in situ synthesized arrays is that the quality of each individual probe can be confirmed before deposition. In contrast,.the quality of probes cannot be assessed on a probe-by-probe basis for the in situ synthesized microarrays presently being used.

43 The genome-derived single exon microarrays of the present invention are also distinguished over, and present substantial benefits over, the genome-derived microarrays from lower eukaryotes such as yeast. Lashkari et al., Px-oc. Natl. Acad. Scl. USA 94:13057-13062 (1997).

Only about 220 - 250 of the 6100 or so nuclear genes in Saccharomyces cerevislae - that is, only about 4 - 5% - have standard, spliceosomal, introns, Lopez et al., Nucl. Acids Res. 28:85-86 (2000); Spingola et al. ' RNA 5 (2):221-34 (1999). Furthermore, the entire yeast genome has already been sequenced. These two facts permit the ready amplification and disposition of single-ORF amplicons on such microarray without the requirement for antecedent use of gene prediction and/or comparative sequence analyses.

Thus, a significant aspect of the present invention is the ability to identify and to confirm expression of predicted coding regions in genomic sequence drawn from eukaryotic organisms that have a higher percentage of genes having introns than do yeast such as Saccharomyces ce- revislae, particularly in genomic sequence drawn from eukaryotes in which at least about 10, 20 or 50% of protein-encoding genes have introns. In preferred embodiments, the methods and apparatus of the present invention are used to identify and confirm expression of novel genes from genomic sequence of eukaryotes in which the average number of introns per gene is at least about one, two or three or more.

After the physical substrate is prepared, experimental verification of predicted function is performed.

In a preferred embodiment of the present invention, where the function sought to be identified in genomic sequence is protein coding, experimental 44 verification is performed by measuring expression of the putative ORFs, typically through nucleic acid hybridization experiments, and in particularly preferred embodiments, through hybridization to genome- derived single exon microarrays prepared as above- described.

Expression is conveniently measured and expressed f or each probe in the microarray as a ratio of the expression measured concurrently in a plurality of mRNA sources, according to techniques well known in the microarray art, Reviewed in Schena et al., and as further described in Example 2, below. The mRNA source for the reference against which specific expression is measured can be drawn from a homogeneous mRNA source, such as a single cultured cell-type, or alternatively can be heterogeneous, as from a pool of mRNA derived from multiple tissues and/or cell types, as further described in Example 2, infra.

mRNA can be prepared by standard techniques, see Ausubel et al. and Maniatis et al., or purchased commercially. The mRNA is then typically reverse- transcribed in the presence of labeled nucleotides: the index source (that in which expression is desired to be measured) is reverse transcribed in the presence of nucleotides labeled with a first label, typically a f luorophore (f luorochrome; f luor; f luorescent dye); the reference source is reverse transcribed in the presence of a second label, typically a fluorophore, typically fluorometrically-distinguishable from the first label. As further described in Example 2, infra, Cy3 and CyS dyes prove particularly useful in these methods. After partial purification of the index and reference targets, hybridization to the probe array is conducted according to standard techniques, typically under a coverslip.

After wash, microarrays are conveniently scanned using a commercial microarray scanning device, such as a Gen3 Scanner (Molecular Dynamics, Sunnyvale, CA) Data on expression is then passed, with or without interim storage, to process 500, where the results for each probe are related to the original sequence.

often, hybridization of target material to the genome-derived single exon microarray will identify certain of the probes thereon as of particular interest. Thus, it is often desirable that the user be able readily to obtain sufficient quantities of an individual probe, either for subsequent arrayed deposition upon an additional support substrate,' often as part of a microarray having a plurality of probes so identified, or alternatively or additionally as a solitary solid-phase or solution-phase probe, for further use.

Thus, in another aspect, the present invention provides compositions and kits for the ready production of nucleic acids identical in sequence to, or substantially identical in sequence to, probes on the genome-derived single exon microarrays of the present invention.

I.n this aspect, a small quantity of each probe is disposed, typically without attachment to substrate, in a spatial ly- addressable ordered set, typically one per well of a microtiter dish. Although a 96 well microtiter plate can be used, greater efficiency is obtained using higher density arrays, such as are provided by microtiter plates having 384, 864, 1536, 3456, 6144, or 9600 wells, and although microtiter plates having physical depressions (wells) are conveniently used, any device that permits addressable withdrawal of reagent from fluidly- noncommunicating areas can be used.

In this aspect of the invention, therefore, a fluidly noncommunicating addressable ordered set of individual probes, corresponding to those on a genomederived single exon microarray, is provided, with each probe in sufficient quantity to permit amplification, such 46 as by PCR. As earlier mentioned, the ORF-specific 51 primers used for genomic amplification can have a first common sequence added thereto, and the ORF-specific 31 primers used for genomic amplification can have a second, different, common sequence added thereto, thus permitting, in this preferred embodiment, the use of a single set of 511 and 31 primers to amplify any one of the probes from the amplifiable ordered set.

Each discrete amplifiable probe can also be packaged with amplification primers, solutes, buffers, etc., and can be provided in dry (e.g., lyophilized) form or wet, in the latter case typically with addition of agents that retard evaporation.

In another aspect of the present invention, a genome-derived single-exon microarray is packaged together with such an ordered set of amplifiable probes corresponding to the probes, or one or more subsets of probes, thereon. In alternative embodiments, the ordered set of amplifiable probes is packaged separately from the genome-derived single exon microarray.

In some embodiments., the microarray and/or ordered probe set are further packaged with recordable media that provide probe identification and addressing information, and that can additionally contain annotation information, such as gene expression data. Such recordable media can be packaged with the microarray, with the ordered probe set, or with both.

If the microarray is constructed on a substrate that incorporates recordable media, such as is described in international patent application no. WO 98/12559, then separate packaging of the genome-derived single exon microarray and the bioinformatic information is not required.

The amount of amplifia ble probe material should 47 be sufficient to permit at least one amplification sufficient for subsequent hybridization assay.

Although the use of high density genome-derived microarrays on solid planar substrates is presently a preferred approach for the physical confirmation and characterization of the expression of sequences predicted to encode protein, other types of microarrays (as herein defined) can also be used.

Furthermore, as earlier mentioned, experimental verification of the function predicted from genomic sequence in process 200 can be bioinformatic, rather than, or additional to, physical verification.

For example, where the function desired to be identified is protein coding, the predicted ORFs can be compared bioinformatically to sequences known or suspected of being expressed.

Thus, the sequences output from process 300 (or process 200), can be usedto query expression databases, such as EST databases, SNP ("single nucleotide polymorphism11) databases, known cDNA and mRNA sequences, SAGE C'serial analysis of gene expression,') databases, and more generalized sequence databases that allow query for expressed sequences. Such query can be done by any sequence query algorithm, such as BLAST (,,basic local alignment search tool"). The results of such query including information on identical sequences and information on nonidentical sequences that have diffuse or focal regions of sequence homology to the query sequence can then be passed directly to process 500, or used to inform analyses subsequently undertaken in process 200, process 300, or process 400.

Experimental data, whether obtained by physical or bioinformatic assay in process 400, is passed to process 500 where it is usefully related to the sequence data itself, a process colloquially termed,annotation". Such 48 annotation can be done using any technique that usefully relates the functional information to the sequence, as, for example, by incorporating the functional data into the record itself, by linking records in a hierarchical or relational database, by linking to external databases, or by a combination thereof. Such database techniques are well within the skill in the art.

The annotated sequence data can be stored locally, uploaded to genomic sequence database 100, and/or displayed 800.

The methods and apparatus of the present invention rapidly produce functional information from genomic sequence. Coupled with the escalating pace at which sequence. now accumulates, the rapid pace of sequence annotation produces a need for methods of displaying the information in meaningful ways.

FIG. 3 shows visual display 80 presenting a single genomic sequence annotated according to the present invention. Because of its nominal resemblance to artistic works of Piet Mondrian, visual display 80 is alternatively described herein as a 11Mondrianll.

Each of the visual elements of display 80 is aligned with respect to the genomic sequence being annotated (hereinafter, the "annotated sequence".). Given the number of nucleotides typically represented in an annotated sequence, representation of individual nucleotides would rarely be readable in hard copy output of display 80. Typically, therefore, the annotated sequence is schematized as rectangle 89, extending from the left border of display 80 to its right border. By convention herein, the leftborder of rectangle 89 represents the first nucleotide of the sequence and the right border of rectangle 89 represents the last nucleotide of the sequence.

As further discussed below, however, the Mondrian 49 visual display of annotated sequence can serve as a convenient graphical user interface for computerized representation, analysis, and query of information stored electronically. For such use, the individual nucleotides can conveniently be linked to the X axis coordinate of rectangle 89. This permits the annotated sequence at any point within rectangle 89 readily to be viewed, either automatically - for example, by timedelayed appearance of a small overlaid window upon movement of a cursor or other pointer over rectangle 89 - or through user intervention, as by clicking a mouse or other pointing device at a point in rectangle 89.

Visual display 80 is generated after user specification of the genomic sequence to be displayed.

Such specification can consist of or include an accession number for a single clone (e.g., a single BAC accessioned into GenBank), wherein the starting and stopping nucleotides are thus absolutely identified, or alternatively can consist of or include an anchor or fulcrum point about which a chosen range of sequence is anchored, thus providing relative endpoints for the sequence to be displayed. For example, the user can anchor such a range about a given chromosomal map location, gene name, or even a sequence returned by query for similarity or identity to an input query sequence. When visual display 80 is used as a graphical user interface to computerized data, additional control over the first and last displayed. nucleotide will typically be dynamically selectable, as by use of standard zooming and/or selection tools.

Field 81 of visual display 80 is used to present the output from process 200, that is, to present the bioinformatic prediction of those sequences having the desired function within the genomic sequence. Functional so sequences are typically indicated by at least one rectangle 83 (83a, 83b, 83c), the left and right borders of which respectively indicate, by their Xaxis coordinates, the starting and ending nucleotides of the region predicted to have function.

Where a single bioinformatic method or approach identifies a plurality of regions having the desired function, a plurality of rectangles 83 is disposed horizontally in field 81. Where multiple methods and/or approaches are used to identify function, each such method and/or approach can be represented by its own series of horizontally disposed rectangles 83, each such horizontally disposed series of rectangles offset vertically from those representing the results of the other methods and approaches.

Thus, rectangles 83a in FIG. 3 represent the functional predictions of a first method of a first approach for predicting function, rectangles 83b represent the functional predictions of a second method and/or second approach for predicting that function, and rectangles 83c represent the predictions of a third method and/or approach.

Where the function desired to be identified is protein coding, field 81 is used to present the bioinformatic prediction of sequences encoding protein.

For example, rectangles 83a can represent the results from GRAIL or GRAIL II, rectangles 83b can represent the results from GENEFINDER, and rectangles 83c can represent the results from DICTION.

Optionally, and preferably, rectangles 83 collectively representing predictions of a single method and/or approach are identically colored and/or textured, and are distinguishable from the color and/or texture used for a different method and/or approach.

Alternatively, or in addition, the color, hue, 51 density, or texture of rectangles 83 can be used further to report a measure of the bioinformatic reliability of the prediction. For example, many gene prediction programs will report a measure of the reliability of prediction.

Thus, increasing degrees of such reliability can be indicated, e.g., by increasing density of shading. Where display 80 is used as a graphical user interface, such measures of reliability, and indeed all other results output by the program, can additionally or alternatively be made accessible through linkage from individual rectangles 83, as by timedelayed window (,,tool tip,' window), or by pointer (e.g., mouse) activated link.

As earlier described, increased predictive reliability can be achieved by requiring consensus among methods and/or approaches to determining function. Thus, field 81 can include a horizontal series of rectangles 63 that indicate one or more degrees of consensus in predictions of function.

Although FIG. 3 shows three series of horizontally disposed rectangles in field 81, display 80 can include as few as one such series of rectangles and as many as can discriminably be displayed, depending upon the number of methods and/or approaches used to predict a given function.

Furthermore, field 81 can be used to show predictions of a plurality of different functions.

However, the increased visual complexity occasioned by such display makes more useful the ability of the user to select a single function for display. When display 80 is used as a graphical user interface for computer query and analysis, such function can usefully be indicated and userselectable, as by a series of graphical buttons or tabs (not shown in FIG. 3).

Rectangle 89 is shown in FIG. 3 as including 52 interposed rectangle 84. Rectangle 84 represents the portion of annotated sequence for which predicted functional information has been assayed physically, with the starting and ending nucleotides of the assayed material indicated by the X axis coordinates of the left and right borders of rectangle 84. Rectangle 85, with optional inclusive circles 86 (86a, 86b, and 86c) displays the results of such physical assay.

Although a single rectangle 84 is shown in FIG.

3, physical assay is not limited to just one region of annotated genomic sequence. It is expected that an increasing percentage of regions predicted to have function by process 200 will be assayed physically, and that display 80 will accordingly, for any given genomic sequence, have.

an increasing number of rectangles 84 and 85, representing an increased density of sequence annotation.

Where the function desired to be identified is protein coding, rectangle 84 identifies the sequence of the probe used to measure expression. In embodiments of the present invention where expression is measured using genome-derived single exon microarrays, rectangle 84 identifies the sequence included within the probe immobilized on the support surface of the microarray. As noted sup-ra, such probe will often include a small amount of additional, synthetic, material incorporated during amplification and designed to permit reamplification of the probe, which sequence is typically not shown in display 80.

Rectangle 87 is used to present the results of bioinformatic assay of the genomic sequence. For example, where the function desired to be identified is protein coding, process 400 can include bioinformatic query of expression databases with the sequences predicted in process 200 to encode exons. And as earlier discussed, because bioinformatic assay presents fewer constraints than 53 does physical assay, often the entire output of process 200 can be used for such assay, without further subsetting thereof by process 300. Therefore, rectangle 87 typically need not have separate indicators therein of regions submitted for bioinformatic assay; that is, rectangle 87 typically need not have regions therein analogous to rectangles 84 within rectangle 89.

Rectangle 87 as shown in FIG. 3 includes smaller rectangles 880 and 88. Rectangles 880 indicate regions that returned a positive result in the bioinformatic assay, with rectangles 88 representing regions that did not return such positive results. Where the function desired to be predicted and displayed is protein coding, rectangles 880 indicate regions of the predicted exons that identify sequence with significant similarity in expression databases, such as EST, SNP, SAGE databases, with rectangles 88 indicating genes novel over those identified in existing expression data bases.

Rectangles 880 can further indicate, through color, shading, texture, or the like, additional information obtained from bioinformatic assay.

For example, where the function assayed and displayed is protein coding, the degree of shading of rectangles 880 can be used to represent the degree of sequence similarity found upon query of expression databases. The number of levels of discrimination can be as few as two (identity, and similarity, where similarity has a user-selectable lower threshold). Alternatively, as many different levels of discrimination can be indicated as can visually be discriminated.

Where display 80 is used as a graphical user interface, rectangles 880 can additionally provide links directly to the sequences identified by the query of expression databases, and/or statistical summaries thereof As with each of the precedingly-discussed uses of display 54 as a graphical user interface, it should be understood that the information accessed via display 80 need not be resident on the computer presenting such display, which often will be serving as a client, with the linked information resident on one or more remotely located servers.

Rectangle 85 displays the results of physical assay of the sequence delimited by its left and right borders.

Rectangle 85 can consist of a single rectangle, thus indicating a single assay, or alternatively, and increasingly typically, will consist of a series of rectangles (85a, 85b, 85c) indicating separate physical assays of the same sequence.

where the function assayed is gene expression, and where gene expression is assayed as herein described using simultaneous two-color fluorescent detection of hybridization to genomederived single exon microarrays, individual rectangles 85 can be colored to indicate the degree of expression relative to control. Conveniently, shades of green can be used to depict expression in the sample over control values, and shades of red.used to depict expression less than control, corresponding to the spectra of the Cy3 and Cy5 dyes conventionally used for respective labeling thereof. Additional functional information can be provided in the form of circles 86 (86a, 86b, 86c), where the diameter of the circle can be used to indicate expression intensity. As discussed infra, such relative expression (expression ratios) and absolute expression (signal intensity) can be expressed using normalized values.

where display 80 is used as a graphical user interface, rectangle 85 can be used as a link to further information about the assay. For example, where the assay is one for gene expression, each rectangle 85 can be used to link to information about the source of the hybridized mRNA, the identity of the control, raw or processed data from the microarray scan, or the like.

FIG. 4 is rendition of display 80 representing gene prediction and gene expression for a hypothetical BAC, showing conventions used in the Examples presented infra.

BAC sequence ("Chip seq.11) 89 is presented, with the physically assayed region thereof (corresponding to rectangle 84 in FIG. 3) shown in white. Algorithmic gene predictions are shown in field 81, with predictions by GRAIL shown, predictions by GENEFINDER, and predictions by DICTION shown. Within rectangle 87, regions of sequence that, when used to query expression databases, return identical or similar sequences PEST hit") are shown as white rectangles (corresponding to rectangles 880 in FIG.

* 3), gray indicates low homology, and black indicates unknowns (where black and gray would correspond to rectangles 88 in FIG. 3).

Although FIGS. 3 and 4 show a single stretch of sequence, uninterrupted from left to right, longer sequences are usefully represented by vertical stacking of such individual Mondrians, as shown in FIGS. 9 and 10.

Single Exon Probes Useful For Measuring Gene Expression The methods and apparatus of the present invention rapidly produce functional information from genomic sequence. Where the function to be identified is protein coding, the methods and apparatus of the present invention rapidly identify and confirm the expression of portions of genomic sequence that function to encode protein- As a direct result, the methods and apparatus of the present invention rapidly yield large numbers of 56 single-exon nucleic acid probes, the majority from previously unknown genes, each of which is useful for measuring and/or surveying expression of a specific gene in one or more tissues or cell types. 5 It is, therefore, another aspect of the present invention to provide genome- derived single exon nucleic acid probes useful for gene expression analysis, and particularly for gene expression analysis by microarray. Using the methods and genome-derived single-exon microarrays of the present invention, we have for example readily identified a large number of unique ORFs from human genomic sequence. Using single exon probes that encompass these ORFs, we have demonstrated, through microarray hybridization analysis, the expression of 5,081 of these ORFs in heart.

As would immediately be appreciated by one of skill in the art, each single exon probe having demonstrable expression in heart is currently available for use in measuring the level of its ORF1s expression in heart. The utility is specific to the probe; at sufficiently high hybridization stringency, which stringencies are well known in the art - see Ausubel et al. and Maniatis et al. - each probe reports the level of expression of message specifically containing that ORP. 25 It should be appreciated, however, that the probes of the present invention, for which expression in the heart has been demonstrated are useful for both measurement in the heart and for survey of expression in other tissues. 30 Significant among such advantages is the presence of probes for novel genes. As mentioned above and further detailed in Examples 1 and 2, the methods described enable ORFs which are not present in existing expression databases to be 57 identified. And the fewer the number of tissues in which the ORF can be shown to be expressed, the more likely the ORF will prove to be part of a novel gene: as further discussed in Example 2, ORFs whose expression was measurable in only a single of the tested tissues were represented in existing expression databases at a rate of only 11%, whereas 36% of ORFs whose expression was measurable in 9 tissues were present in existing expression databases, and fully 45% of those ORFs expressed in all ten 10 tested tissues were present in existing expressed sequence databases.

Either as tools for measuring gene expression or tools for surveying gene expression, the genome-derived single exon probes of the present invention have significant advantages over the cDNA or EST-based probes that are currently available for achieving these utilities.

The genome-derived single exon probes of the present invention are useful in constructing genome-derived single exon microarrays; the genomederived single exon microarrays, in turn, are useful devices for measuring and for surveying gene expression in the human.

Gene expression analysis using microarrays conventionally using microarrays having probes derived from expressed message - is wellestablished as useful in the biological research arts (see Lockhart et al. Nature 405, 827-836).

Microarrays have been used to determine gene expression profiles in cells in response to drug treatment (see, for example, Kaminski et al., "Global Analysis of Gene Expression in Pulmonary Fibrosis Reveals Distinct Programs Regulating Lung Inflammation and FibrosisA" Proc. Natl. Acad. Sci. USA 97 (4):1778-83 (2000); Bartosiewicz et al., "Development of a Toxicological Gene Array and Quantitative Assessment of This Technology," Arch. Blochem.

58 Biophys. 376 (1):66-73 (2000), viral infection (see for example, Geiss et al., "Large-scale Monitoring of Host Cell Gene Expression During HIV-1 Infection Using cDNA Microarrays, 11 Virology 266 (1):8-16 (2000H and during cell processes such as differentiation, senescence and apoptosis (see, for example, Shelton et al.,11Microarray Analysis of Replicative Senescence, 11 Curr. Biol. 9 (17):939-45 (1999); Voehringer et al., "Gene Microarray Identification of Redox and Mitochondrial Elements That Control Resistance or Sensitivity to Apoptosis,11 Proc. Natl. Acad. Sci. USA 97 (6):2 680 -5 (2000)).

Microarrays have also been used to determine abnormal gene expression in diseased tissues (see, for example, Alon et al., "Broad Patterns of Gene Expression Revealed by Clustering Analysis of Tumor and Normal Colon Tissues Probed by Oligonucleotide Arrays,11 Proc. Natl.

Acad. Scl. USA 96 (12):6745-50 (1999); Perou et al., "Distinctive Gene Expression Patterns in Human Mammary Epithelial Cells and Breast Cancers, Proc. Natl. Acad. Scl.

USA 96 (16):9212-7 (1999); Wang et al., "Identification of Genes Dif f erentially Over-expressed in Lung Squamous Cell Carcinoma Using Combination of cDNA Subtraction and Microarray Analysis," Oncogene 19 (12):1519-28 (2000) Whitney et al., "Analysis of Gene Expression in Multiple Sclerosis Lesions Using cDNA Microarrays, 11 Ann. Neurol.

46 (3):425-8 (1999)), in drug discovery screens (see, for example, Scherf et al., "A Gene Expression Database for the Molecular Pharmacology of Cancer," Nat. Genet. 24(3):236-44 (2000H and in diagnosis to determine appropriate treatment strategies (see, for example, Sgroi et al., "in vivo Gene Expression Profile Analysis of Human Breast Cancer Progression, 11 Cancer Res. 59 (22):5656-61 (1999)).

In microarray- based gene expression screens of pharmacological drug candidates upon cells, each probe 59 provides specific useful data. In particular, it should be appreciated that even those probes that show no change in expression are as informative as those that do change, serving, in essence, as negative controls.

For example, where gene expression analysis is used to assess toxicity of chemical agents on cells, the failure of the agent to change a gene's expression level is evidence that the drug likely does not affect the pathway of which the gene's expressed protein is a part.

Analogously, where gene expression analysis is used to assess side effects of pharmacological agents - whether in lead compound discovery or in subsequent screening of lead compound derivatives - the inability of the agent to alter a gene's expression level is evidence that the drug does not affect the pathway of which the gene's expressed protein is a part.

WO 99/58720 provides methods for quantifying the relatedness of a first and second gene expression profile and for ordering the relatedness of a plurality of gene expression profiles. The methods so described permit useful information to be extracted from a greater percentage of the individual gene expression measurements from a microarray than methods previously used in the art.

Other uses of microarrays are described in Gerhold et al., Trends Blochem. Scl. 24(5):168-173 (1999) and Zweiger, Trends Blotechnol. 17 (11):429-436 (1999) Schena et al.

The invention particularly provides genome derived single-exon probes known to be expressed in heart.

The individual single exon probes can be provided in the form of substantially isolated and purified nucleic acid, typically, but not necessarily, in a quantity sufficient to perform a hybridization reaction.

Such nucleic acid can be in any form directly hybridizable to the message that contains the probe I s ORF, such as double stranded DNA, single-stranded DNA complementary to the message, single-stranded RNA complementary to the message, or chimeric DNA/RNA molecules so hybridizable. The nucleic acid can alternatively or additionally include either nonnative nucleotides, alternative internucleotide linkages, or both, so long as complementary binding can be obtained. For example, probes can include phosphorothioates, methylphosphonates, morpholino analogs, and peptide nucleic acids (PNA), as are described, for example, in U.S. Patent Nos. 5,142,047; 5,235,033; 5,166,315; 5,217, 866; 5,184,444; 5,861,250.

Usefully, however, such probes are provided in a form and quantity suitable for amplification, where the amplified product is thereafter to be used in the hybridization reactions that probe gene expression. Typically, such probes are provided in a form and quantity suitable for amplification by PCR or by other well known amplification technique. one such technique additional to PCR is rolling circle amplification, as is described, inte-r alla, in U.S. Patent Nos. 5,854,033 and 5,714,320 and international patent publications WO 97/19193 and WO 00/15779. As is well understood, where the probes are to be provided in a form suitable for amplification, the range of nucleic acid analogues and/or internucleotide linkages will be constrained by the requirements and nature of the amplification enzyme.

Where the probe is to be provided in form suitable for amplification, the quantity need not be sufficient for direct hybridization for gene expression analysis, and need be sufficient only to function as an amplification template, typically at least about 1, 10 or 100 pg or more.

Each discrete amplifiable probe can also be 61 packaged with amplification primers, either in a single composition that comprises probe template and primers, or in a kit that comprises such primers separately packaged therefrom. As earlier mentioned, the ORF- specific 51 primers used for genomic amplification can have a first common sequence added thereto, and the ORF-specific 31 primers used for genomic amplification can have a second, different, common sequence added thereto, thus permitting, in this embodiment, the use of a single set of 5 1 and 31 primers to amplify any one of the probes. The probe composition and/or kit can also include buffers, enzyme, etc., required to effect amplification.

As mentioned earlier, when intended for use on a genome-derived single exon microarray of the present invention, the genome-derived single exQn probes of the present invention will typically average at least about 100, 200, 300, 400 or 500 bp in length, including (and typically, but not necessarily centered about) the ORF. Furthermore, when intended for use on a genome-derived single exon microarray of the present invention, the genome-derived single exon probes of the present invention will typically not contain a detectable label.

When intended for use in solution phase hybridization, however - that is, for use in a hybridization reaction in which the probe is not first bound to a support substrate (although the target may indeed be so bound) length constraints that are imposed in microarray- based hybridization approaches will be relaxed, and such probes will typically be labeled.

In such case, the only functional constraint that dictates the minimum size of such probe is that each such probe must be capable of specifically identifying in a hybridization reaction the exon from which it is drawn. In theory, a probe of as little as 17 nucleotides is capable 62 of uniquely identifying its cognate sequence in the human genome. For hybridization to expressed message - a subset of target sequence that is much reduced in complexity as compared to genomic sequence - even fewer nucleotides are required for specificity.

Therefore, the probes of the present invention can include as few as 20, 25 or 50 bp or ORF, or more. In particular embodiments, the ORF sequences are given in SEQ ID NOS. 5,203---10,283, respectively, for probe SEQ ID NOS.

1 - 5,202. The minimum amount of ORF required to be included in the probe of the present invention in order to provide specific signal in either solution phase or mi croarray- based hybridizations can readily be determined for each of ORF SEQ ID NOS. 5,203 - 10,283 individually by routine experimentation using standard high stringency conditions.

Such high stringency conditions are described, inter alla, in Ausubel et al. and Maniatis et al. For mi croarray based hybridization, standard high stringency conditions can usefully be 50% formamide, 5X SSC, 0.2 gg/gl poly (dA), 0. 2 pg/M1 human c,tl DNA, and 0. 5 % SDS, in a humid oven at 420C overnight, followed by successive washes of the microarray in 1X SSC, 0.2% SDS at 550C for 5 minutes, and then 0.1X SSC, 0.2% SDS, at 550C for 20 minutes.. For solution phase hybridization, standard high stringency conditions can usefully be aqueous hybridization at 650C in 6X SSC. Lower stringency conditions, suitable for cross-hybridization to mRNA encoding structurally- and functionally related proteins, can usefully be the same as the high stringency conditions but with reduction in temperature for hybridization and washing to room temperature (approximately 25OC).

When intended for use in solution phase hybridization, the maximum size of the single exon probes 63 of the present invention is dictated by the proximity of other expressed exons in genomic DNA: although each single exon probe can include intergenic and/or intronic material contiguous to the ORF in the human genome, each probe of the present invention will include portions of only one expressed exon.

Thus, each single exon probe will include no more than about 25 kb of contiguous genomic sequence, more typically no more than about 20 kb of contiguous genomic sequence, more usually no more than about 15 kb, even more usually no more than about 10 kb. Usually, probes that are maximally about 5 kb will be used, more typically no more than about 3 kb.

It will be appreciated that the Sequence Listing appended hereto presents, by convention, only that strand of the probe and ORF sequence that can be directly translated reading from 51 to 31 end. As would be well understood by one of skill in the art, single stranded probes must be complementary in sequence to the ORF as present in an mRNA; it is well within the skill in the art to determine such complementary sequence. It will further be understood that double stranded probes can be used in both solution-phase hybridization and mi croarray- based hybridization if suitably denatured.

Thus, it is an aspect of the present invention to provide single-stranded nucleic acid probes that have sequence complementary to those described herein above and below, and double-stranded probes one strand of which has sequence complementary to the probes described herein.

The probes can, but need not, contain intergenic and/or intronic material that flanks the ORF, on one or both sides, in the same linear relationship to the ORF that the intergenic and/or intronic material bears to the ORF in genomic DNA. The probes do not, however, contain nucleic acid derived from more than one expressed ORF.

64 And when intended for use in solution hybridization, the probes of the present invention can usefully have detectable labels. Nucleic acid labels are well known in the art, and include, inter alla, radioactive labels, such as 3 H ' 32p, 33p, 35S, 12SI, 131j; fluorescent labels, such as Cy3, Cy5, Cy5.5, Cy7, SYBRO Green and other labels described in Haugland, Handbook of Fluorescent Probes and Research Chemicals, 7th ed., Molecular Probes Inc., Eugene, OR (2.000), or fluorescence resonance energy transfer tandem conjugates thereof; labels suitable for chemi luminescent and/or enhanced chemiluminescent detection; labels suitable for ESR and NMR detection; and labels that include one member of a specific binding pair, such as biotin, digoxigenin, or the like.

The probes, either in quantity sufficient for hybridization or sufficient for 'amplification, can be provided in individual vials or containers.

Alternatively, such probes can usefully be packaged as a plurality of such individual genome-derived single exon probes.

When provided as a collection of plural individual probes, the. probes are typically made available in amplifiable form in a spatial ly- addres sableordered set, typically one per well of a microtiter dish. Although a 9.6 well microtiter plate can be used, greater efficiency is obtained using higher density arrays.

If, as earlier mentioned, the ORF-specific 51 primers used for genomic amplification had a first common sequence added thereto, and the ORF-specific 31 primers used for genomic amplification had a second, different, common sequence added thereto, a single set of 51 and 31 primers can be used to amplify all of the probes from the amplifiable ordered set.

Such collections of genome-derived single exon probes can usefully include a plurality of probes chosen for the common attribute of expression in the human heart.

In such defined subsets, typically at least 50, 60, 75, 80, 85, 90 or 95% or more of the probes will be chosen by their expression in the defined tissue or cell type.

The single exon probes of the present invention, as well as fragments of the single exon probes comprising selectively hybridizable portions of the probe ORF, can be used to obtain the full length cDNA that includes the ORP by (i) screening of cDNA libraries; (ii) rapid amplification of cDNA ends ("RACW); or (iii) other conventional means, as are described, inter alla, in Ausubel et al. and Maniatis et al.

It is another aspect of the present invention to provide genome-derived single exon nucleic acid microarrays useful for gene expression analysis, where the term llmicroarrayll has the meaning given in the definitional section of this description, supra.

The invention particularly provides genomederived single-exon nucleic acid microarrays comprising a plurality of probes known to be expressed in human heart. In preferred embodiments, the present invention provides human genome-derived single exon microarrays comprising a plurality of probes drawn from the group consisting of SEQ ID NOS.: 1 - 5,202.

When used for gene expression analysis, the genome-derived single exon microarrays provide greater physical informational density than do the genome-derived single exon microarrays that have lower percentages of probes known to be expressed commonly in the tested tissue. At a fixed probe density, for example, a given microarray surface area of the defined subset genome-derived single 66 exon microarray can yield a greater number of expression measurements. Alternatively, at a given probe density, the same number of expression measurements can be obtained from a smaller substrate surface area. Alternatively, at a fixed probe density and fixed surface area, probes can be provided redundantly, providing greater reliability in signal measurement for any given probe. Furthermore, with a higher percentage of probes known to be expressed in the assayed tissue, the dynamic range of the detection means can be adjusted to reveal finer levels discrimination among the levels of expression.

Although particularly described with respect to their utility as probes of gene expression, particularly as probes to be included on a genomederived single exon microarray, each of the nucleic acids having SEQ ID NOS.: 1 - 5,202 contains an openreading frame, set forth respectively in SEQ ID NOS.: 5, 203 - 10,283, that encodes a protein domain. Thus, each of SEQ ID NOS. 1 - 5,202 can be used, or that portion thereof in SEQ ID NOS. 51203 - 101283 used, to express a protein domain by standard in vitro recombinant techniques. See Ausubel et al. and Maniatis et al.

Additionally, kits are available commercially that readily permit such nucleic acids to be expressed as protein in bacterial cells, insect cells, or mammalian cells, as desired (e.g., HAT Protein Expression & Purification System, ClonTech Laboratories, Palo Alto, CA; Adeno-X' Expression System, ClonTech Laboratories, Palo Alto, CA; Protein Fusion & Purification (pMALm) System, New England Biolabs, Beverley, MA) Furthermore, shorter peptides can be chemically synthesized using commercial peptide synthesizing equipment and well known techniques. Procedures are described, inter alia, in Chan et al. (eds.), Fmoc Solid Phase Peptide 67 Synthesis: A Practical Approach (Practical Approach Series, (Paper)), Oxford Univ. Press (March 2000) (ISBN:

0199637245); Jones, Amino Acid and Peptide Synthesis (Oxford Chemistry Primers, No 7) Oxford Univ. Press (August 1992) (ISBN: 0198556683) and Bodanszky, Principles of Peptide Synthesis (Springer Laboratory), Springer Verlag (December 1993) (ISBN: 0387564314).

It is, therefore, another aspect of the invention to provide peptides comprising an amino acid sequence translated from SEQ ID NOS.: 5,203 10,283. Such amino acid sequences are set out in SEQ ID NOS: 10,284 15,322.

Any such recombinantly- expressed or synthesized peptide of at least 8, and preferably at least about 15, amino acids, can be conjugated to a carrier protein and used to generate antibody that recognizes the peptide. Thus, it is a further aspect of the invention to provide peptides that have at least 8, preferably at least 15, consecutive amino acids.

The following examples are offered by way of illustration and not by way of limitation.

EXAMPLE 1

Preparation of Single Exon Microarrays from ORFs Predicted in Human Genomic Sequence Bioinformatics Results All human BAC sequences in fewer than 10 pieces that had been accessioned in a five month period immediately preceding this study were downloaded from GenBank. This corresponds to -2200 clones, totaling 350 MB of sequence, or approximately 10% of the human genome.

After masking repetitive elements using the program CROSS - MATCH, the sequence was analyzed for open reading frames using three separate gene finding programs.

68 The three programs predict genes using independent algorithmic methods developed on independent training sets: GRAIL uses a neural network, GENEFINDER uses a hidden Markoff model, and DICTION, a program proprietary to Genetics Institute, operates according to a different heuristic. The results of all three programs were used to create a prediction matrix across the segment of genomic DNA.

The three gene finding programs yielded a range of results. GRAIL identified the greatest percentage of genomic sequence as putative coding region, 2% of the data analyzed. GENEFINDER was second, calling 1%, and DICTION yielded the least putative coding region, with 0. 8% of genomic sequence called as coding region.

The consensus data were as follows. GRAIL and GENEFINDER agreed on 0.7% of genomic sequence, GRAIL and DICTION agreed on 0.5% of genomic sequence, and the three programs together agreed on 0. 25% of the data. analyzed. That is, 0.25% of the genomic sequence was identified by all three of the programs as containing putative coding region.

ORFs predicted by any two of the three programs Pconsensus ORFs11) were assorted into "gene bins" using two criteria: (1) any 7 consecutive exons within a 25 kb window were placed together in a bin as likely contributing to a single gene, and (2) all ORFs within a 25 kb window were placed together in a bin as likely contributing to a single gene if fewer than 7 exons were found within the 25 kb window.

PCR The largest ORF f rom each gene bin that did not span repetitive sequence was then chosen for amplification, as were all consensus ORFs longer than 500 bp. This method approximated one exon per gene; however, a number of genes 69 were found to be represented by multiple elements.

Previously, we had determined that DNA fragments fewer than 250 bp in length do not bind well to the aminomodified glass surface of the slides used as support substrate for construction of microarrays; therefore, amplicons were designed in the present experiments to approximate 500 bp in length.

Accordingly, after selecting the largest ORF per gene bin, a 500 bp fragment of sequence centered on the ORF was passed to the primer picking software, PRIMER3 (available online for use at http://www-genome.wi.mit.edu/cgi-bin/primer/ A first additional sequence was commonly added to each ORF-unique 51 primer, and a second, different, additional sequence was commonly added to each ORP-unique 31 primer, to permit subsequent reamplification of the amplicon using a single set of "universal" 51 and 31 primers, thus immortalizing the amplicon. The addition of universal priming sequences also facilitates sequence verification, and can be used to add a cloning site should some ORFs be found to warrant further study.

The ORPs were then PCR amplified from genomic DNA, verified on agarose gels, and sequenced using the universal primers to validate the identity of the amplicon to be spotted in the microarray.

Primers were supplied by Operon Technologies (Alameda, CA). PCR amplification was performed by standard techniques using human genomic DNA (Clontech, Palo Alto, CA) as template. Each PCR product was verified by SYBRO green (Molecular Probes, Inc., Eugene, OR) staining of agarose gels, with subsequent imaging by Fluorimager (Molecular Dynamics, Inc., Sunny-vale, CA). PCR amplification was classified as successful if a single band appeared.

The success rate for amplifying ORFs of interest directly from genomic DNA using PCR was approximately 75%. FIG. 5 graphs the distribution of predicted ORF (exon) length and distribution of amplified PCR products, with ORF length shown in red and PCR product length shown in blue (which may appear black in the figure). Although the range of ORF sizes is readily seen to extend to beyond 900 bp, the mean predicted exon size was only 229 bp, with a median size of 150 bp (n=9498) With an average amplicon size of 475 + 25 bp, approximately 50% of the average PCR amplification product contained predicted coding region, with the remaining 50% of the amplicon containing either intron, intergenic sequence, or both.

Using a strategy predicated on amplifying about 500 bp, it was found that long exons had a higher PCR failure rate. To address this, the bioinformatics process was adjusted to amplify 1000, 1500 or 2000 bp fragments from exons larger than 500 bp. This improved the rate of successful amplification of exons exceeding 500 bp, constituting about 9.2% of the exons predicted by the gene finding algorithms.

Approximately 75% of the probes disposed on the array (90% of those that successfully PCR amplified) were sequence -verified by sequencing in both the forward and reverse direction using MegaBACE sequencer (Molecular Dynamics, Inc., Sunnyvale, CA), universal primers, and standard protocols.

Some genomic clones (BACs) yielded very poor PCR and sequencing results. The reasons for this are unclear, but may be related to the quality of early draft sequence or the inclusion of vector and host contamination in some submitted sequence data.

Although the intronic and intergenic material flanking coding regions could theoretically interfere with hybridization during microarray experiments, subsequent empirical results demonstrated that differential expression 71 ratios were not significantly affected by the presence of noncoding sequence. The variation in exon size was similarly found not to affect differential expression ratios significantly; however, variation in exon size was observed to affect the absolute signal intensity (data not shown).

The 350 MB of genomic DNA was, by the abovedescribed process, reduced to 9750 discrete probes, which were spotted in duplicate onto glass slides using commercially available instrumentation (MicroArray GenII Spotter and/or MicroArray GenIII Spotter, Molecular Dynamics, Inc., Sunnyvale, CA). Each slide additionally included either 16 or 32 E. col! genes, the average hybridization signal of which was used as a measure of background biological noise.

Each of the probe sequences was BLASTed against the human EST data set, the NR data set, and SwissProt GenBank (May 7, 1999 release 2.0.9).

One third of the probe sequences (as amplified) produced an exact match (BLAST Expect ("E") values less than 1 e-100) to either an EST (20% of sequences) or a known mRNA (13% of sequences) A further 22% of the probe sequences showed some homology to a known EST or mRNA (BLAST E values from 1 e5 to 1 e-99). The remaining 45% of the probe sequences showed no significant sequence homology to any expressed, or potentially expressed, sequences present in public databases.

All of the probe sequences (as amplified) were then analyzed for protein similarities with the SwissProt database using BLASTX, Gish et al., Nature Genet. 3:266 (1993). The predicted functional breakdowns of the 2/3 of probes identical or homologous to known sequences are presented in Table 1.

72 Table 1

As can be seen, the two most common types of genes were transcription factors and receptors, making up 5 2.2% and 1.8% of the arrayed elements, respectively.

EXAMPLE 2 Gene Expression Measurements From Genome-Derived Single 10 Exon Microarrays The two genome-derived single exon microarrays prepared 'according to Example 1 were hybridized in a series 15 of simultaneous two-color fluorescence experiments to (1) Function of Predicted ORFs As Deduced From Comparative Sequence Analysis Total V6 chip V7 chip Function Predicted from Comparative Sequence Analysis 211 96 115 Receptor 43 77 Zinc Finger 11 19 Homeobox 9 16 Transcription Factor 17 11 7 Transcription 118 57 61 Structural 39 56 Kinase 36 18 18 Phosphatase 83 31 52 Ribosomal 19 26 Transport 21 17 14 Growth Factor 17 12 5 Cytochrome so 33 17 Channel 73 Cy3-labeled cDNA synthesized from message drawn individually from each of brain, heart, liver, fetal liver, placenta, lung, bone marrow, HeLa, BT 474, or HBL 100 cells, and (2) CyS-labeled cDNA prepared from message pooled from all ten tissues and cell types, as a control in each of the measurements. Hybridization and scanning were carried out using standard protocols and Molecular Dynamics equipment.

Briefly, mRNA samples were bought from commercial sources (Clontech, Palo Alto, CA and Amersham Pharmacia Biotech (APB)). Cy3-d= and CyS-d= (both from APB) were incorporated during separate reverse transcriptions of 1 gg of polyA' mRNA performed. using 1 gg ol igo (dT) 12 -18 primer and 2 gg random 9mer primers as follows. After heating to 700C, the RNA:primer mixture was snap cooled on ice. After snap cooling on ice, added to the RNA to the stated final concentration was: 1X Superscript II buffer, 0.01 M DTT, 10OgM clATP, 100 gM dGTP, 100 pM dTTP, 50 gM dCTP, 50 gM Cy3-d= or CyS-d= 50 gM, and 200 U Superscript II enzyme. The reaction was incubated for 2 hours at 420C. After 2 hours, the first strand cDNA was isolated by adding 1 U Ribonuclease H, and incubating for 30 minutes at 370C. The reaction was then purified using a Qiagen PCR cleanup column, increasing the number of ethanol washes to 5.

Probe was eluted using 10 mM Tris pH 8.5.

Using a spectrophotometer, probes were measured for dye incorporation. Volumes of both Cy3 and CyS cDNA corresponding to 50 pmoles of each dye were then dried in a Speedvac, resuspended in 30 M1 hybridization solution containing 50% formamide, 5X SSC, 0.2 gglgl poly(dA), 0.2 gglgl human c,, tl DNA, and 0.5 % SDS.

Hybridizations were carried out under a coverslip, with the array placed in a humid oven at 420C overnight. Before scanning, slides were washed in 1X SSC, 0.2c-.' SDS at 550C for 5 minutes, followed by 0.1X SSC, 0.2% 74 SDS, at 55'C for 20 minutes. Slides were briefly dipped in water and dried thoroughly under a gentle stream of nitroge n.

Slides were scanned using a Molecular Dynamics Gen3 scanner, as described. Schena (ed.), Microarray Biochip: Tools and Technology, Eaton Publishing Company/ B i oTechnique s Books Division (2000) (ISBN: 1881299376).

Although the use of pooled cDNA as a reference permitted the survey of a large number of tissues, it attenuates the measurement of relative gene expression, since every highly expressed gene in the tissue/cell typespecific fluorescence channel will be present to a level of at least 10% in the control channel. Because of this fact, both signal and expression ratios (the latter hereinafter, "expression" or "relative expression") for each probe were normalized using the average ratio or average signal, respectively, as measured across the whole slide.

Data were accepted for further analysis only when signal was at least three times greater than biological noise, the latter defined by the average signal produced by the B. col! control genes.

The relative expression signal for these probes was then plotted as function of tissue or cell type, and is presented in FIG. 6.

FIG. 6 shows the distribution of expression across a panel of ten tissues. The graph shows the number of sequence-verified products that were either not _ expressed (11 0 11), expressed in one or more but not all tested tissues (111n - 11911), and expressed in all tissues tested (111011).

Of 9999 arrayed elements on the two microarrays (including positive and negative controls and "failed" products), 2353 (51%) were expressed in at least one tissue or cell type. of the gene elements showing significant signal - where expression was scored as "significant" if the normalized Cy3 signal was greater than 1, representing signal 5-fold over biological noise (0.2) - 39% (991) were expressed in all 10 tissues. The next most common class (15%) consisted of gene elements expressed in only a single tissue.

The genes expressed in a single tissue were further 'analyzed, and the results of the analyses are compiled in FIG. 7.

FIG. 7A is a matrix presenting the expression of all verified sequences that showed expression greater than 3 in at least one tissue. Each clone is represented by a column in the matrix. Each of the 10 tissues assayed is is represented by a separate row in the matrix. and relative expression of a clone in that tissue is indicated at the respective node by intensity of green shading, with the intensity legend shown in panel B. The top row of the matrix PEST Hit") contains 11bioinformatic11 rather than "physical" expression data - that is, presents the results returned by query of EST, NR and SwissProt databases using the probe sequence. The legend for 11bioinformatic expression,' (i.e., degree of homology returned) is presented in panel C. Briefly, white is known, black is novel, with gray depicting nonidentical with significant homology (white: E values < le-100; gray: E values from le05 to le99; black.. E values > le-05) As FIG. 7 readily shows, heart and brain were demonstrated to have the greatest numbers of genes that were shown to be uniquely expressed in the respective tissue. In brain, 200 uniquely expressed genes were identified; in heart, 150. The remaining tissues gave the following figures for uniquely expressed genes: liver, 100; lung, 70; fetal liver, 150; bone marrow, 75; placenta, 100; 76 HeLa, 50; HBL, 100; and BT474, 50.

It was further observed that there were many more "novel" genes among those that were up-regulated in only one tissue, as compared with those that were down-regulated in only one tissue. In fact, it was found that ORFs whose expression was measurable in only a single of the tested tissues were represented in sequencing databases at a rate of only 11%, whereas 36% of the ORFs whose expression was measurable in 9 of the tissues were present in public databases. As for those ORFs expressed in all ten tissues, fully 45% were present in existing expressed sequence databases. These results are not unexpected, since genes expressed in a greater number of tissues have a higher likelihood of being, and thus of having been, discovered by EST approaches.

Comparison of Signal from Known and Unknown Genes The normalized signal of the genes found to have high homology to genes present in the GenBank human EST database were compared to the normalized signal of those genes not found in the GenBank human EST database. The data are shown in FIG. 8.

FIG. 8 shows the normalized Cy3 signal intensity for all sequence -veri f ied products with a BLAST Expect (11E11) value of greater than le-30 (designated "unknown") upon query of existing EST, NR and SwissProt databases, and shows in blue the normalized Cy3 signal intensity for all sequence -verified products with a BLAST Expect value of less than le-30 Pknown"). Note that biological background noise has an averaged normalized Cy3 signal intensity of 0.2.

As expected, the most highly expressed of the ORFs were "known" genes. This is not surprising, since very high signal intensity correlates with very commonly- expressed genes, which have a higher likelihood of being 77 found by EST sequence.

However, a significant point is that a large number of even the high expressers were "unknown". Since the genomic approach used to identify genes and to confirm their expression does not bias exons toward either the 31 or 5 1 end of a gene, many of these high expression genes will not have been detected in an end-sequenced cDNA library.

The significant point is that presence of the gene in an EST database is not a prerequisite for incorporation into a genome-derived microarray, and further, that arraying such "unknown,' exons can help to assign function to as-yet undiscovered genes.

Verification of Gene Expression To ascertain the validity of the approach described above to identify genes from raw genomic sequence, expression of two of the probes was assayed using reverse transcriptase polymerase chain reaction (RT PCR) and northern blot analysis.

Two microarray probes were selected on the basis of exon size, prior sequencing success, and tissue-specific gene expression patterns as measured by the microarray experiments. The primers originally used to amplify the two respective ORFs from genomic DNA were used in RT PCR against a panel of tissue-specific cDNAs (Rapid-Scan gene expression panel 24 human cDNAs) (oriGene Technologies, Inc., Rockville, MD).

Sequence AL079300 - 1 was shown by microarray hybridization to be present in cardiac tissue, and sequence AL0317341 was shown by microarray experiment to be present in placental tissue (data not shown). RT-PCR on these two sequences confirmed the tissue-specific gene expression as measured by microarrays, as ascertained by the presence of 78 a correctly sized PCR product from the respective tissue type cDNAs.

Clearly, all microarray results cannot, and indeed should not, be confirmed by independent assay methods, or the high throughput, highly parallel advantages of microarray hybridization assays will be lost. However, in addition to the two RT-PCR results presented above, the observation that 1/3 of the arrayed genes exist in expression databases provides powerful confirmation of the power of our methodology - which combines bioinformatic prediction with expression confirmation using genomederived single exon microarrays - to identify novel genes from raw genomic data.

To verify that the approach further provides correct characterization of the expression patterns of the identified genes, a detailed analysis was performed of the microarrayed sequences that showed high signal in brain.

For this latter analysis, sequences that showed high (normalized) signal in brain, but which showed very low (normalized) signal (less than 0.5, determined to be biological noise) in all other tissues, were further studied. There were 82 sequences that fit these criteria, approximately 2% of the arrayed elements. The 10 sequences showing the highest signal in brain in microarray hybridizations are detailed in Table 2, along with assigned function, if known or reasonably predicted.

Table 2 Function of the Most Highly Expressed Genes Expressed Only in Brain Microarray Normal Expressi Homology Gene Function Sequence i zed on Ratio to EST as described by Name Signal present GenBank 79 in GenBank AP000217-1 5.2 +.7 High S-100 protein, b-chain, Ca 2+ binding protein expressed in central nervous system AP000047-1 2.3 High Unknown Function AC006548-9 1.7 High Similar to mouse membrane glyco-protein M6, expressed in central nervous system AC007245-5 1.5 High Similar to amphiphysin, a synaptic vesicle associated protein. Ref 21 L441404 1.2 +2.0 High Endothelial actin-binding protein found in nonmuscle filamin AC004689-9 1.2 +3.5 High Protein Phosphatase PP2A, neuronal/ downregulates activated protein kinases AL031657-1 1.2 +3.0 High Unknown function/ Contains the anhyrin motif, a common protein sequence motif AC009266-2 1.1 +3.7 Low Low homology to the Synaptotagmin I protein in rat/present at low levels throughout rat brain AP000086-1 1.0 +2.7 Low Unknown, very poor homology to collagen AC004689-3 1.0 High Protein Phosphatase PP2A, neuronal/ downregulates activated protein kinases Of the ten sequences studied by these latter confirmatory approaches, eight were previously known. Of these eight, six had previously been reported to be important in the central nervous system or brain. The exon giving the highest signal (AP00217-1) was found to be the gene encoding an S100B Ca 2' binding protein, reported in the literature to be highly and uniquely expressed in the central nervous system. Heizmann, Neurochem. Res. 9:1097 (1997).

A number of the brain-specific probe sequences 81 (including AC006548-9, AC009266-2) did not have homology to any known human cDNAs in GenBank but did show homology to rat and mouse cDNAs. Sequences AC004689-9 and AC004689-3 were both found to be phosphatases present in neurons (Millward et al., Trends Blochem. Sci. 24(5):186-191 (1999)). Two microarray sequences, AP000047-1 and AP000086-1 have unknown function, with AP000086-1 being absent from GenBank. Functionality can now be narrowed down to a role in the central nervous system f or both of these genes, showing the power of designing microarrays in this fashion.

Next, the function of the chip sequences with the highest (normalized) signal intensity in brain, regardless of expression in other tissues, was assessed. In this is latter analysis, we found expression of many more common genes, since the sequences were not limited to those expressed only in brairi. For example, looking at.the 20 highest signal intensity spots in brain, 4 were similar to tubulin (AC00807905; AF146191-2; AC007664-4; AF14191-2), 2 were similar to actin (AL035701-2; AL034402-1), and 6 were found to be homologous to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (AL035604- 1; Z86090-1; AC006064-L, AC006064-K; AC035604-3; AC006064-L). These genes are often used as controls or housekeeping genes in microarray experiments of all types.

Other interesting genes highly expressed in brain were a ferritin heavy chain protein, which is reported in the literature to be found in brain and liver (joshi et al., J. Neurol. Sci. 134 (Suppl):52-56 (1995)), a result duplicated with the array. other highly expressed chip sequences included a translation elongation factor 1 (AC007564-4), a DEAD-box homolog (AL023804-4), and a Ychromosome RNA-binding motif.(Chai et al., Genomics 49 (2):283-89 (1998)) (AC007320-3). A low homology analog 82 (AP00123-1/2) to a gene, DSCR1, thought to be involved in trisomy 21 (Down's syndrome), showed high expression in both brain and heart. in agreement with the literature (Fuentes et al., Mol. Genet. 4 (10):1935-44 (1995) As a further validation of the approach, we selected the BAC AC006064 to be included on the array.

This BAC was known to contain the GAPDH gene, and thus could be used as a control for the ORF selection process.

The gene finding and exon selection algorithms resulted in choosing 25 exons from BAC AC006064 for spotting onto the array, of which four were drawn from the GAPDH gene. Table 3 shows the comparison of the average expression ratio for the 4 exons from BAC006064 compared with the average expression ratio for 5 different dilutions of a commercially available GAPDH cDNA (Clontech) Table 3

Comparison of Expression Ratio, for each tissue, of GAPDH Control ( n 5) AC006064 (n 4) Bone Marrow -1.81 + 0.11 -1.85 + 0.08 Brain -1.41 + 0.11 -1.17 + 0.05 BT474 1.85 + 0.09 1.66 + 0.12 Fetal Liver 1.62 + 0.07 -1.41 0.05 HBL100 1.32 + 0.05 2.64 + 0.12 Heart 1.16 + 0.09 1.56 + 0.10 HeLa 1.11 +0.06 1.30 + 0.15 Liver -1.62 + 0.22 -2.07 + Lung -4.95 + 0.93 -3.75 + 0.21 Placenta -3.56 + 0.25 -3.52 + 0.43 Each tissue shows excellentagreement between the 83 experimentally chosen exons and the control, again demonstrating the validity of the present exon mining approach. In addition, the data also show the variability of expression of GAPDH within tissues, calling into question its classification as a housekeeping gene and utility as a housekeeping control in microarray experiments.

EXAMPLE 3 10 Representation of Sequence and Expression Data as a 11Mondrianll For each genomic clone processed for microarray as above -described, a plethora of information was accumulated, including full clone sequence, probe sequence within the clone, results of each of the three gene finding programs, EST information associated with the probe sequences, and microarray signal and expression for multiple tissues, challenging our ability to display the information.

Accordingly, we devised a new tool for visual display of the sequence with its attendant annotation which, in deference to its visual similarity to the paintings of Piet Mondrian, is hereinafter termed a 11Mondrianll. FIGS. 3 and 4 present the key to the information presented on a Mondrian.

FIG. 9 presents a Mondrian of BAC AC008172 (bases 25,000 to 130,000 shown), containing the carbamyl phosphate synthetase gene (AF154830.1). Purple background within the region shown as f ield 81 in FIG. 3 indicates all 37 known exons for this gene.

As can be seen, GRAIL II successfully identified 27 of the known exons (73%), GENEFINDER successfully identified 37 of the known exons (100%), while DICTION identified 7 of the known exons (19%).

84 Seven of the predicted exons were selected for physical assay, of which 5 successfully amplified by PCR and were sequenced. These five exons were all found to be f rom the same gene, the carbamyl phosphate synthetase gene (AF154 83 0. 1).

The f ive exons were arrayed, and gene expression measured across 10 tissues. As is readily seen in the Mondrian, the f ive chip sequences on the array show identical expression patterns, elegantly demonstrating the reproducibility of the system.

FIG. 10 is a Mondrian of BAC AL049839. We selected 12 exons from this BAC, of which 10 successfully sequenced, which were f ound to f orm between 5 and 6 genes. Interestingly, 4 of the genes on this BAC are protease is inhibitors. Again, these data elegantly show that exons selected from the same gene show the same expression patterns, depicted below the red line. From this figure, it is clear that our ability to find known genes is very good. A novel gene is also found from 86.6 kb to 88.6 kb, upon which all the exon finding programs agree. We are confident we have two exons from a single gene since they show the same expression patterns and the exons are proximal to each other. Backgrounds in the following colors indicate a known gene (top to bottom):

red = kallistatin protease inhibitor (P29622) purple = plasma serine protease inhibitor (P05154) turquoise = al anti -chymotrypsin (P01011); mauve = 40S ribosomal protein (P08865) Note that chip sequence.8. and 12 did not sequence verify.

EXAMPLE 4 Genome-Derived Single Exon Probes Useful For Measuring Human Gene Expression The protocols set forth in Examples 1 and 2, supra, were applied to additional human genomic sequence as it became newly available in GenBank. 5,081 unique exons in the human genome that could be shown to be expressed at significant levels in heart tissue were identified.

These unique exons are within longer probe sequences. Each probe was completely sequenced on both strands prior to its use on a genome-derived single exon microarray; sequencing confirms the exact chemical structure of each probe. An added benefit of sequencing is that it placed us in possession of a set of single baseincremented fragments of the sequenced nucleic acid, starting from the sequencing primer 31 OH. (Since the single ekon probes were first obtained by PCR amplification from genomic DNA, we were of course additional ly in possession of an even larger set of single base incremented fragments of each of the 5,1202 single exoh probes, each fragment corresponding to an extension product from one of the two amplification primers.) The structures of the 5,202 unique single exon probes are clearly presented in the Sequence Listing as SEQ ID Nos.: 1 5,202. The 16 nt 51 primer sequence and 16 nt 31 primer sequence present on the amplicon are not included in the sequence listing. The sequences of the exons present within each of these probes is presented in the Sequence Listing as SEQ ID Nos.: 5, 203 - 10,283, respectively. It will be noted that some amplicons have more than one exon, some exons are contained in more than one amplicon.

As detailed in Example 2, expression was demonstrated by disposing the amplicons as single exon probes on nucleic acid microarrays and then performing twocolor fluorescent hybridization analysis; significant 86 expression is based on a statistical confidence that the signal is significantly greater than negative biological control spots. The negative biological control is formed from spotted DNA sequences from a different species. Here, 32 sequences from E.Coli were spotted in duplicate to give a total of 64 spots.

For each hybridisation (each slide, each colour) the median value of the signal from all of the spots is determined. The normalised signal value is the arithmetic mean of the signal from duplicate spots divided by the population median.

Control spots are eliminated if there is more that a five-fold difference between each one of the duplicate spots raw signals.

The median of the signal from the remaining control spots is calculated and all subsequent calculations are done with normalised signals.

Control spots having a signal of greater than median + 2.4 (the value 2.4 is roughly 12 times the observed standard deviation of control spot populations) are eliminated. Spots with such high signals are considered tobe 'I'loutliersll. The mean and standard deviation of the modified control spot populations are calculated. 25 The mean + 3x the standard deviation (mean + (3SD)) is used as the signal threshold qualifier for that particular hybridisation. Thus, individual thresholds are determined for each channel and each hybridisation. This means that, assuming that the data is distributed normally, there is a 99% confidence that any signal exceeding the threshold is significant.

The probes and their expression data are presented in Table 4, set forth respectively in Example 5. Example 5 presents the subset of probes that is significantly expressed in the human heart and thus 87 presents the subset of probes that was recognized to be useful for measuring expression of their cognate genes in human heart tissue.

The sequence of each of the exon probes ident i f ied by SEQ ID NOS.: 5, 2 0 3 to 10, 2 8 3 was individual ly used as a BLAST (or, for SWISSPROT, BLASTX) query to identify the most similar sequence in each of dbEST, SwissProt (BLASTX), and NR divisions of GenBank. Because the query sequences are themselves derived from genomic sequence in GenBank, only nongenomic hits from NR were scored.

The smallest in value of the BLAST (or BLASTX) expect PIE11) scores for each query sequence across the three database divisions was used as a measure of the "expression novelty', of the probe's ORF. Table 4 is sorted in descending order based on this measure, reported as "Most Similar (top) Hit BLAST E Value". 29 out of the 5081 exons were found to have no similar sequences.

As sorted, Table 4 thus lists its respective probes (by 11AMPLICON SEQ ID NO.:" and additionally by the SEQ ID NO:. of the exon contained within the probe-11EXON SEQ ID NO.: 11) from least similar to sequences known to be expressed (i.e., highest BLAST E value), at the beginning of the table, to most similar to sequences known to be expressed (I.e., lowest BLAST E value), at the bottom of the table.

Table 4 further provides, for each listed probe, the accession number. of the database sequence that yielded the "Most Similar (top) Hit BLAST E Value", along with the name of the database in which the database sequence is found ("Top Hit Database Source").

Table 4 further provides SEQ ID NOS. corresponding to the predicted amino acid sequences where they have been determined for the probe and exon nueleotide 88 sequences. These are set out as PEPTIDE SEQ ID NOS.:. The peptide sequences f or a given exon are predicted as follows: Since each chip exon is a consensus sequence drawn from predictions from various exon finding programs (i.e.

Grail, GeneFinder and GenScan), the multiple initial ORFs are first determined in a uniform way according to each prediction. In particular, the reading frame for predicting the first amino acid in the peptide sequence always starts with the f irst base of any codon and ends with the last base of non-termination codon. Next, for each strand of the exon, initial ORFs are merged into one or more final ORFs in an exhaustive process based on the following criteria:

1) the merging ORFs must be overlapping, and 2) the merging ORFs must be in the same frame.

The Sequence Listing, which is a superset of all of the data presented in Table 4, further includes, for each probe, the most similar hit, with 'accession number and BLAST E value, from the each of the three queried databases.

Table 4 further lists, for each probe, a portion of the descriptor for the top hit ("Top Hit Descriptorll) as provided in the sequence database. For those ORFs that are similar in sequence, but nonidentical to known sequences (e.g., those with BLAST E values between about le-05 and le-100), the descriptor reveals the likely function of the protein encoded by the probe's ORF.

Using BLAST E value cutoffs of le-05 (i.e., 1 x 10-5) and le-100 (i.e., 1 x 100.) as evidence of similarity to sequences known to be expressed is of course arbitrary:

in Example 2, sup-ra, a BLAST E value of le-30 was used as the boundary when only two classes were to be defined for analysis (unknown, >le-30; known <le-30) (see also FIG. 8) Furthermore, even when the "Most Similar (Top) Hit BLAST E Value', is low, e.g., less than about le-100 - which is 89 probative evidence that the query sequence has previously been shown to be expressed - the top hit is highly unlikely exactly to match the probe sequence.

First, such expression entries typically will not have the intronic and/or intergenic sequence present within the single exon probes listed in the Table. Second, even the ORF itself is unlikely in such cases to be present identically in the databases, since most of the EST and niRNA clones in existing databases include multiple exons, without any indication of the location of exon boundaries.

As noted, the data presented in Table 4 represent a proper subset of the data present within the attached sequence listing. For each amplicon probe (SEQ ID N0s.: 1 - 5, 202) and probe exon (SEQ ID N0s.: 5,203 - 10, 283, respectively), the sequence listing further provides, through iterated annotation fields <220> and <223>:

(a) the accession number of the BAC from which the sequence was derived ("MAP TW), thus providing a link to the chromosomal map location and other information about the genomic milieu of the probe sequence; (b) the most similar sequence provided by BLAST query of the EST database, with accession number and BLAST E value for the "hitel; - (c) the most similar sequence provided by BLAST query of the'GenBank NR database, with accession number and BLAST E value for the "hitfl; and (d) the most similar sequence provided by BLASTX query of the SWISSPROT database, with accession number and BLAST E value for the ';hit".

EXAMPLE 5

Genome-Derived Single Exon Probes Useful For Measuring Expression of Genes in Human Heart Table 4 presents expression, homology, and functional information for the genome-derived single exon probes that are expressed significantly in human heart.

Table 4

AMPLICON EXON PEPTIDE EXPRESSION HIT HIT ACCESSION DATASET HIT DESCRIPTION

SECI ID SEQ SEQ ID EVALUE NO: ID NO: NO:

286 5473 10603 0.7 287 5473 10603 0.7 442 5608 10741 1.5 871 6019 11179 5.8 1029 6169 0.7 1280 6410 11571. 2.7 1597 6723 11893 0,7 1619 6745 11913 1.8 1694 6818 11999 1.0 1715 6838 12017 1.0 1721 6844 12023 2.7 1848 6966 12152 1.0 1935 7052 12245 1.1 2119 7230 12439 1.0 2233 7340 12552 0.8 2893 8044 13144 5.9 3003 8155 13255 1.0 3003 8155 13256 1.0 3149 8298 13407 3,7 3403 8545 13653 1.5 3471 8612 13724 9.0 3513 8654 0.9 3607 8746 13841 1.0 4102 9228 14313 1.7 4164 9290 14370 5.9 4184 9310 14390 0.9 4184 9310 14391 0.9 4242 9367 1.0 4730 9842 14934 1.8 4779 9889 0.8 4976 10079 15149 5.1 4988 10091 15161 2.1 578 5738 10854 0.7 9.8OE+00 AA442238.1 EST-HUMAN zv61g01.sl Soares testis NHT Homo sapiens cDNA clone IMAGE:758160 3' 2631 7721 12921 1.0 9.40E+00 L1 1433.1 NT Dengue virus type 3 membrane protein (prWMVenvelope glycoproteln (E) polyprotein mRNA, partial cds 2631 7721 12922 1.0 9.4OE+00 L1 1433.1 NT Dengue virus type 3 membrane protein (prWMyenvelope glycoprotein (E) polyprotein mRNA, partial cds Page 1 of 196 Table 4

C4 W_ Page 2 of 196 433 5600 10731 0.6 8,40E+00 5031804 NT Homo saplens Insulin receptor substrate 1 (IRS1) mRNA 2947 8098 13203 4.2 7.2OE+00 L12051.1 NT Lyaopersicon esculentum Mill. GTPase (SAR2) mRNA, complete cds 2947 8098 13204 4.2 7.2OE+00 L12051.1 NT Lycopersicon esculentum Mill. GTIPase (SAR2) mRNA, complete cds 3479 8620 0.8 5.8OE+00 7661557 NT Homo sapiens DESC1 protein (DESC1), mRNA 4675 9787 14886 1.5 5.3OE+00 L43126,1 NT Bovine Immunodeficlency-like virus surface envelope gene, V end of cds 3972 9104 9.4 4.8OE+00 AF185255.1 NT Eunice australls histone H3 (H3) gene, partial cds 3236 8384 13490 4.0 4.7OE+00 AL163280.2 NT Homo saplens chromosome 21 segment HS21 C080 3459 8600 13713 3.9 3.9OE+00 XW18.1 NT Ktabacurn chifinase gene 50 for class 1 chifinase C 4226 9350 1.0 3.9OE+00 AF055466.1 NT Mus musculus seminal vesicle secretory protein 99 (MSVS1299) gene, promoter region 2588 7681 0.9 3.8OE+00 AE001562.1 NT Helicobacter pylorl, strain J99 section 123 of 132 of the complete genome 3936 9070 14154 10.1 3.7OE+00 ALI 61539.2 NT Arabidopsis thallana DNA chromosome 4, config fragment No. 39 3946 9079 5.1 3.7OE+00 AF014880.1 NT Enterobacter agglomerans Coffil - like plasmid RNA one modulator (rom) gene, complete cds 3209 8357 13466 1.0 3.5OE+00 AF221538.1 NT Cryptosporldium fells heat shock protein 70 (HSP70) gene, partial eds 1496 6622 11792 1.3 3.4OE+00 AF254577.1 NT Brassica napus RP135d mRNA, complete cds 2532 7628 12830 1.0 3.4OE+00 AL163278.2 NT Homo sapiens chromosome 21 segment HS21 C078 5036 10136 15211 1.4 3.3OE+00 7662155 NT Homo sapiens KIAA0480 gene product (K1AA0480), mRNA 5036 10136 15212 1.4 3.3012+00 7662155 NT Homo sapiens KIAA0480 gene product (K1AA0480), mRNA 492 5657 10780 1.4 3.2OE+00 X96422.1 NT D.rerio p-50 POU gene 3938 5657 10780 0.8 3.2OE+00 X96422.1 NT D.redo zp-50 POU gene 4482 9602 1.5 3.2OE+00 A.1403571.1. NT M.musculus DNA for GFAP-binding fragment GFAPB27 2807 7959 13067 1.1 3.OOE+00 8923984 NT Homo sapiens hypothetical protein PROO889 (PROO889), mRNA 1964 7080 12279 0.9 2.9OE+00 AE002225.2 1 Chlamydophila pneumonlae AR39, section 53 of 94 of the complete genome 2114 7225 12433 1.1 2.9OE+00 AF055477.1 NT Rattus norvegicus pore-forming calcium channel alpha-1 B subunit variant a mRNA, NT alternatively spliced product, complete cds 1441 6568 11744 2.1 2.8OE+00 AF185398.1 NT Buxus harlandil maturase K (matK) gene, partial cels; chloroplast gene for chloroplast product 1615 6741 1.1 2.8OE+00 AL161552.2 NT Arabidopsis thaliana DNA chromosome 4, config fragment No. 52 230 5421 10544 1.6 2.7OE+00 6679306 NT Mus musculus per-hexamer repeat gene 3 (Phxr3), mRNA 230 5421 10545 1.6 2.7OE+00 6679306 NT Mus musculus per-hexamer repeat gene 3 (Phxr3), mRNA 2923 8074 13182 1.5 2.7OE+00 4504548 NT Homo sapien hexabrachion (tenascin C, cytotactin) (HXB) mRNA 3904 9039 14130 1.5 2.7OE+00 AF195052.1 NT Danio redo proteasome activator subunit 1 (psmel) mRNA, complete cds 461 5627 10754 1.0 2.6OE+00 AE002369.1 NT Neisseda meningiddis sefogroup B strain MC58 section 11 of 206 of the complete genome 461 5627 10755 1.0 2.6012+00 AE002369.1 NT Neisseria meningiddis serogroup B strain MC58 section 11 of 206 of the complete genome 3526 8667 13771 0.8 2.6OE+00 AF1 11168.2 NT Homo sapiens sedne palmitoyl transferase, subunit 11 gene, complete cds; and unknown genes 8869 13961 0.8 2.6OE+00 AW966084.1 EST HUMAN EST378157 MAGE resequences, MAGI Homo saplens cDNA 8869 13962 0.8 -2-.-60-E+00 AW966084.1 EST HUMAN EST378157 MAGE resequences, MAGI Homo sapiens cDNA 9693 14785 4.4 2.6OE+00 AF068749.1 NT Mus musculus sphingosine kinase (SPHKlb) mRNA, complete cds Table 4

1448 65f5- 11748 0.8 2.5OE+00 A.1271844.1 NT Aspergillus nidulans recQ gene for DNA holicase, exons 1-4 1448 6575 11749 0.8 2.5OE+00 AJ271844.1 NT Aspergillus nidulans recQ gene for DNA helicase, exons 1-4 2503 7600 0.8 2.4OE+00 P19532 SWISSPROT TRANSCRIPTION FACTOR E3 2980 6131 13239 0,9 2.4OE+00 M24282.1 NT Chicken alpha-3 collagen type VI mRNA, Y end 3201 8349 13462 3.0 2.4OE+00 068906 SWISSPROT TRYPTOPHAN SYNTHASE ALPHA CHAIN 4816 9925 15017 76 2.4OE+00 4503352 NT Homo sapiens double C2-like domains. alpha (DOC2A) mRNA 1233 6362 11524 3.2 2.3OE+00 Z46724.1 NT G.domesticus ardficial single chain antbody'gene (1.3) 1371 6499 11665 0.8 2.3OE+00 AF180891.1 NT Danio redo fast skeletal muscle myosin light polypepfide 3 (myiz3) mRNA, complete cds 2639 7728 1.2 2.3OE+00 A1.163209.2 NT Homo sapiens chromosome 21 segment HS21C009 4031 9159 1.3 2.3OE+00 AJ401081.1 NT Bos taurus partial cytb g ne r cytochrome b 4216 9340 14423 3.8 2.2OE+00 D67071.1 NT Rat gene for regucalcin, exonll (non-coding exon) 4216 9340 14424 18 2.2OE+00 D67071.1 NT Rat gene for regucaldn, exonl (non-coding exon) 557 7892 10836 2.3 2.1012+00 AF132612.2 NT Mus musculus pre-T cell receptor alpha gene, enhancer region and upstream re ion 830 5979 11140 0.8 2.1OE+00 6912721 NT Homo sapiens tolloid-like 1 (TLLI), mRNA 3539 8680 1,2 2.1OE+00 AW449366.1 EST HUMAN Ul-H-B13-aki-e-08-0-Ul.sl NCI CGAP_Sub5 Horno saplens cDNA clone IMAGE:2734550 X 3715 8852 13942 1.6 2.1OE+00 5835149 NT Gorilla gorilla mitochondrion, complete genome 3715 8852 13943 1 ' 6 2.1OE+00 5835149 NT Gorilla gorilla mitochondrion, complete genome 3785 8922 14016 1.3_ 2.1OE+00 AF257470.1 NT Equus caballus calcitonin gene related pepdde 11 precursor, mRNA, complete cds 1178 6311 11466 1.2 2.OOE+00 AF180527.1 NT Homo sapiens p22DoWel (DOKOEL) mRNA, complete cds 1178 6311 11467 1.2 2.OOE+00 AF180527.1 NT Homo sapiens p22DoWel (DOWEL) mRNA, complete cds 1313 6441 11608 1.4 2.OOE+00 AF204927.1 NT Oryclolagus cuniculus Na+,K+ATPase beta 1 subunit mRNA, complete ods 1557 6684 1.1 2.OOE+00 P25582 SWISSPROT PUTATIVE RRNA METHYLTRANSFERASE SPB1 2102 7213 12422 1.7_ 2.OOE+00 Z78279.1 NT R.norvegicus mRNA for collagen alphal type 1 2102 7213 12423 1.7 2.OOE+00 Z78279.1 NT R.norvegicus mRNA for collagen alphal type 1 4011 9142 1 2.1 2.OOE+00 AW664496.1 EST HUMAN W13c05.xl NCI_CGAP_GUI Homo saplens cDNA done IMAGE:2972168 Ysimilar to 14224 gb.X011677 GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE, LIVER (HUMAN); 4011 9142 14225 2.1 2.OOE+00 AW664496.1 EST HUMAN W13c05.xl NCI - CGAP - GUI Homo saplens cDNA done IMAGE:2972168 3'similar to qb:X01677 GLCERALDEHYDE 3-PHOSPHAT-E DEHYDROGENASE, LIVER (HUMAN); 1990 7106 0.7 1.8OE+00 AJ010045.1 NT Mus muscutus mRNA for Rho quanine nucleodde-exchange tctor, splice variant NET1 A 3054 8205 13305 1.7 1.8DE+00 P21004 SWISSPROT PROTEIN B8 PRECURSOR 3082 8233 13331 4.5 1.8OE+00 U04356.1 NT Synechococcus sp. PCC7942 copper transporting P-ATPase (ctaA) and ATP synthase epsilon subunit (atpE) genes, complete cds 3082 8233 13332 4.5 1.8OE+00 U04356.1 NT Synechococcus sp. PCC7942 copper transporting P-ATPase (ctaA) and ATP synthase epsilon subunit (atpE) genes, complete cds 564 5726 10842 0.6 1.70E+00 Q14137 SWISSPROT HYPOTHETICAL PROTEIN KIAA0124 W 5726 10843 0.6 1.70E+00 014137 SWISSPROT HYPOTHETICAL PROTEIN KIAA0124 565 5726 10842 1.1 1.70E+00 Q14137 SWISSPROT HYPOTHETICAL PROTEIN KIAA0124 565 5726 108431 1.1 1.70E+00 014137 SWISSPROT HYPOTHETICAL PROTEIN KIAA0124 Page 3 of 196 Table 4

Page 4 of 196 1092 6230 11381 0.7 1.70E+00 Q60114 SWISSPROT LEVANSUCRASE (BETA-D- FRUCTOIFURANOSYL TRANSFERASE) (SUCROSE 6 FRUCTOSYLTRANSFERASE) 2225 7332 12545 1.2 1.70E+00 AL1 63280.2 NT Homo sapiens chromosome 21 segment HS21C080 2321 7424 12633 1.0 1.70E+00 A1141067.1 EST HUMAN,_pl Homo sapiens cDNA done MAGE:1678137 3 oz43h05.xl Soares NhHMPu 4356 9478 14569 0.8 1.70E+00 Q60114 SWISSPROT LEVANSUCRASE (BETA-D- FRUCTOIFURANOSYL TRANSFERASE) (SUCROSE 6 FRUCTOSYLTRANSFERASE) 5059 10157 1.1 11.7012+00 AA747059.1 EST HUMAN nx65c08.sl NCLCGAP_Alvl, Homo saplens cDNA clone IMAGE: 1267118 similar to gb.DO0723 GLYCINE CLEAVAGE SYSTEM H PROTEIN PRECURSOR (HUMAN); 1989 7104 12307 6,1 11.60E+00 AF199339.1 NT Homo saplens tens epithelium- derived growth factor gene, alternatively spliced, complete eds 1997 7113 12315 1.3 1.6OE+00 AF077374.1 NT Homo sapiens small proline- rich protein (SPRR3) gene, exons 1, 2, and 3 and complete cds 2003 7118 12320 0.7 1.13OE+00 Y1 1344.1 NT Mus musculus ST6GaINAcill gene, exon 2 2238 7344 0.5 11.60E+00 X98373.11 NT B.napus gene encoding endo- polygalacturonase 2931 8082 13190 2.5 1.60E+00 W58426.1 EST-HUMAN zd25f0I.rl Soares_fetal- 'heartNbHH19W Homo sapiens cDNA clone IMAGE:341689 5 similar to gb:D29805 N-ACETYLLACTOSAMINE SYNTHASE (HUMAN); 3795 8932 14026 1.3 1.6OE+00 D64006.1 NT Synechocystis sp. PCC6803 complete genome, 25127. 3138604-3270709 4255 9380 14460 1.4 1.60E+00 AF1155827.1 NT Homo sapiens proliferallon- associated SNIF2-like protein (SMARCA6) mRNA, complete cds 4255 9380 14461 1,4 1.6OE+00 AF155827.1 NT Homo sapiens proliferation- assoclated SINIF2-like protein (SMARCA6) mRNA, complete cds 4359 9481 14572 1.2 1.6OE+00 U34070.1 NT Human CCAATIenhancer binding protein alpha gene, complete cds 5016 10118 15189 3,1 1.60IE+00 Y1 1344.1 NT Mus musculus ST6GaINAcili gene, exon 2 5016 10118 15190 3.1 1.6OE+00 Y1 1344.1 NT Mus musculus ST6GaINAcill gene, exon 2 5239 10344 1,5 1.5012+00 U53449.1 NT Rattus norvegicus jun dimerization protein 2 Gdp-2) mRNA, complete cds 231 5422 10546 0.6 1.50E+00 AE002201.2 NT Chlamyclophila pneumoniae AR39, secdon 32 of 94 of the complete genome 605 5763 0.6 1.5OE+00 6752961 NT Mus musculus a disintegsin and metalloproteinase domain (ADAM) 15 (metargidin) (Adam15), mRNA 2359 7461 12667 0.9 1.50E+00 AJ131402.1 NT Potato virus A RNA complete genome. isolate U 2468 7566 12769 0.7 1.50E+00 6678350 NT Mus musculus T-cell lymphoma invasion and metastasis 1 (Tiam l), mIRNA 3099 7461 12667 2,2 1.5OE+00 AJ131402.1 NT Potato Virus A RNA complete genome, isolate U 3329 8473 13586 0.8 1.5OE+00 AE001945.1 NT Deinococcus radiodurans R1 secdon 82 of 229 of the complete chromosome 1 27 5236 10340 1.3 11.40E+00 7661685 NT ns DKFZP586M0122 protein (DKFZP586M0122), mRNA 27 5236 10341 1.3 1.40E+00 7661685 NT Homo sapiens DKFZP586M0122 protein (DKFZP586M0122), mRNA 2231 7338 1.0 1.40E+00 AF053357.1 NT Helicobacter pori glutamine synthetase (ginA) gene, complete cds 2286 7391 3.4 1.40E+00 U67922.1 NT Ovis afles prion protein gene, complete cds 2634 7723 12926 0.6 1.40E+00 X74463.11 NT Human papitiomavirus type 7 genomic DNA 2746 7830 13032 1,2 11.40E+00 AF064564.2 NT Fugu rubripes nourofibromatosis type 1 (NIF1), A-kinase anchor protein (AKAP84), BAW protein (BAW), and WS81 protein (WSB1) genes, complete cds 2746 7830 13033 1.2 1.40E+00 AFOW64.2 NT Fugu rubripes neurofibromatosis type 1 (NFl), A-kinase anchor protein (AIKAP84), BAW protein (BAW), and WSB1 protein (WSBI) genes, complete cds Table 4

3034 8186 13287 1.0 1.40E+00 AE002324.2 NT Chlamydia mutidarum, section 55 of 85 of the complete genome 3034 8186 13288 1.0 1.40E+00 AE002324.2 NT Chlamydia m ridarum, section 55 of 85 of the complete genome 3291 8437 0.9 1.40E+00 5453733 NT Homo sapiens Mad4 homolog (MAD4) mRNA 4162 9288 14367 1.1 1.40E+00 AW900455.1 EST HUMAN CMO-NNIOOS-140300-286- h06 NN1005 Homo sapiens cDNA cDNA 4162 9288 14368 1.1 1.40E+00 AW900455.1 ESTHUMAN CM0-NW005.140300-286-h06 NNI1005 Homo sapiens 0.8 1.40E+00 Q07869 SWISSPROT PEROYCISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA (PPAR-ALPHA) 5137 10232 10562 0.6 1.30E+00 U67587.1 NT Methanococcus jannaschli section 129 of 150 of the complete genome 248 5436 150 of the 248 5436 10563 0.6 1.30E+00 U67587.1 NT Methanococcus jannaschil section 129 of complete genome 558 5720 0.6 1.30E+00 Z73640.1 NT M.mucedo gene encoding 4-Dihydromethyi- trisporate dehydrogenase 572 7862 0.8 1.30E.00 AL163210.2 NT Homo sapiens chromosome 21 segment HS21 C01 0 884 6032 11191 0.9 1.30E+00 AJ271192.1 NT Cantharellus sp. partial 25S rRNA gene, Isolate Tibet 1113 6250 5.6 1.30E+00 Y19213.1 NT Horno saplens putative psihHbA pseudogene for hair keratin, exons 2 to 7 mR NA 1275 6405 11665 3.7 1.30E+00 4507998 NT Homosapien zinc finger protein 157 (HZF22) (ZNF157) 1275 6405 11566 3.7 1.30E+00 4507998 NT Homo sapiens ziri.e finger protein 157 (HZF22) (ZNFI57) mRNA 1334 6463 0.6 1.3012+00 U61730.2 NT Colx lacryma-jobl dihydrodiploolinate synthase (dapA) gene, complete cds tc24e03xl Soares_totaLfetus_Nb2HF8 9w Homo sapiens cDNA clone IMAGE:2065564 3' similar to contains Alu repetitive elemenFicontains element MER22 repetitive clement; 1361 6489 1.4 1.30E+00 W375930.1 EST_HUMAN 1593 6719 0.8 1.30E+00 AE002338.2 NT Chlamydia_muddarum, section 66 of 85 of the complete genome Cyprinus carplo MRPb and MASPb genes for mannose-binding lectin- assoclated sedne 2196 7305 2.1 1.30E+00 A13030447.1 NT protease (MASP) and MASP-related protein, complete cds 2909 8059 13164 1.1 1.30E+00 6755621 NT Mus musculus alpha-spectrin 1, erythrold (Spnal), mRNA Fugu rubripes gamma.aminobutyric acid receptor beta subunit gene, partial cds; 55W erythrocyte membrane protein (P55), synaptic vesicAe-associated Integral membrane protein (VAMP-1), procollagen C-proteinase enhancer protein (PCOLCE) genes, complete c> 3547 8688 13790 1,0 1.30E+00 AF016494.1 NT 3902 9037 14128 1.0 1.30E+00 D90908.1 NT Synechocystis sp. PCC6803 com let@ genome, 10127.1188886-1311234 4502 8059 1316.4 0.8 1.30E+00 6755621 NT Mus musculus alpha-spectrin 1, erythrold (S al), mRNA 4623 9737 14833 1.3 1.30E+00 AL161472.2 NT Arabidopsis thaliana DNA chromosome 4, config fragment No. 2 4964 10067. 15139 1.0 1.30E+00 AJ252087.1 NT Plasmodium relchenovA partial 83/AMA-1 gene for apical membrane antigen 1 4964 10067 15140 1.0 1.30E+00 AJ252087.1 NT Plasmodium relchenovA partial 83/AMA-1 gene for apical membrane antigen 1 z]22d08.sl Scares_fetaUlveLspleer_1 WLSS1 Homo sapiens cDNA cJone IMAGE:431535 634 5793 10916 2.8 1,20E+00 AA676246.1 EST HUMAN 31 806 5957 11110 1,3 1,20E+00 P05228 SWISSPROT HISTIDINE-RICH PROTEIN PRECURSOR (CLONE PFI-IRP-111) 866 5957 11111 1.3 1.20E+00 P05228 SWISSPROT HISTIDINE-RICH PROTEIN PRECURSOR (CLONE PFI-IRP-111) 806 5957 11112 1.3 1.20E+00 P05228 SWISSPROT HISTIDINE-RICH PROTEIN PRECURSOR (CLONE PFI-IRP-111) 860 6008 0.8 1.20E+00 8924234 NT Homo saple hypothetical p;otein PR03077 (PR03077), mRNA 1145 6280 11433 1.9 1.20E+00 AF080245.2 NT Elaeis otelfera sesquiterpene synthase mRNA, complete cds virus 1187 6319 11475 0.6 1.20E+00 A.1252242.1 NT pea seedome mosaic complete genome 1187 6319 11476 0.6 1.20E+00 AJ252242.1 NT Pea seed-bome mosaic virus complete genome 1963 7079 12278 1,1 1.20E+00 AF140631.1 NT Horno sapiens G-protein coup] d receptor 14 (GIPR14) gene, complete cds Page 5 of 196 Table 4

3072 8223 13321 1.0 1.2OE+00 AB020681.1 NT Homo sapiens mRNA for KIAA0874 protein, partial cds 3128 8277 13383 5.4 1.20E+00 AL161563.2 NT Arabidopsis thallana DNA chromosome 4, condg fragment No. 63 3128 8277 13384 5.4 1.20E+00 ALI 61563,2 NT Arabidopsis thallana DNA chromosome 4, config fragment No. 63 3249 8396 2.9 1.20E+00 P54910 SWISSPROT CONJUGAL TRANSFER PROTEIN TRBE PRECURSOR 3311 8456 13570 0.8 11.20E+00 AF188740.1 NT Homo sapiens 1-HX3 gene. intron 2 3312 8457 1.0 11.20E+00 M81779.1 NT G.aallus T-cadherin mRNA, complete cds 3650 8789 13882 7.3 1.20E+00 U75902.1 NT Mus musculus subdiisin-like serine protease 1-PC (PC7) gene, exons 1 to 9, partial cds 4201 8456 13570 1.1 1.20E+00 AF188740.1 NT Homo sapiens LHX3 gene, Intron 2 4298 9422 14513 1.4 11.20E+00 6980951 NTRattus norvegicus Glycine receptor alpha 2 subunit (glycine receptor, neonatal) (Gira2), mRNA 4371 93 1.6 1.2OE+00 M87060.1 NT Rattus rattus cardiac AE3 gene, exons 1- 23 4422 9542 14634 1.3 11,20E+00 AL1 61509.2 NT Arabidopsis thaliana DNA chromosome 4, config fragment No. 21 4460 9580 14677 1.8 1.20E+00 AF156495.1 NT Homo sapiens post-synapfic density 95 (DLG4) gene, complete cds 4485 9605 5.4 1.20E+00 Y09200.1 NT T.pinnatum chloroplast rbcL gene, partial 4584 8457 0.9 1.20E+00 M81779.1 NT G.gallus T-cadherin mRNA, complete cds 456 5622 10749 1.1 1,10E+00 D86980.1 NT Human mRNA for KIAA0227 gene, partial cds 1726 6849 12028 1.4 1.1OE+00 AW995393.1 EST HUMAN QVO-BN0042-170300-163- 912 BN0042 Homo saplens cDNA 1857 6975 12160 0.9 1.1OE+00 AW575889.1 EST-HUMAN Ul-HF-BROp-ajk-f-02-0-1. 11.sl Nli-I-MGQj52 Homo sapiens cDNA clone IMAGE:3074834 3, 2870 8021 13123 1,0 1. 1 OE+00 AB040955.1 NT Homo sapiens mRNA for KIAA1522 protein, partial cds 2971 8122 13229 0.8 1.1012+00 4501940 NT Homo sapiens alcohol dehydrol;; enase 7 (class IV), mu or sigma polypeptide (ADH7) mRNA 2971 8122 13230 0.8 1. 1 OE+00 4501940 NT Homo saplens, alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (ADH7) mRNA 3288 8433 13541 6.6 1.1OE+00 AL1 63213.2 NT Homo saplens chromosome 21 segment HS21 C01 3 3288 8433 13542 6.6 11.10E+00 AL163213.2 NT Homo saplens chromosome 21 segment HS21 C01 3 3441 8583 13697 0.9 1.1OE+00 8922641 NT Homo saplens hypothetical protein FLJ10749 (FL.110749), mRNA 3468 8609 13721 1.0 1.1012+00 N84066.1 EST HUMAN KK4629F Human fetal heart, Lambda ZAP Express Homo sapiens cDNA clone KK4629 5' similar to ORF(RELATED TO ACTIN BUNDLING PROTEIN DEMATIN) 3510 8651 1.3 1.1OE+00 8922973 NT Homo sapiens hypothetical protein FLJ1 1280 (FLA 1280), mRNA 3531 8672 13776 1.0 1.1OE+00 A1808360.1 EST-HUMAN W54bl 1.xl Soares_NFL_GBC S1 Homo saplens cDNA clone IMAGE:2359461 Ysimilar to SW:P531 HUMAN Q128M Pfi-BINDING PROTEIN 53BP1 3657 8796 13889 1.2 1.1OE+00 AE003886.1 NT Xylella fastidlosa, secdon32 of 229 of the complete genome 3657 8796 13890 1.2 1.10E+00 AE003886.1 NT Xylella fasfidlosa, section 32 of 229 of the complete genome 3678 8817 13910 17.8 11,10E+00 5729757 NT Homo sapiens calpain 9 (nCL-4) (CAPN9 mRNA.

3862 8998 14097 1.0 1. 1 OE+00 8922641 NT Homo saplens hypothetical protein FU10749 (FI-J10749), mRNA 4122 9248 5.9 1.1OE+00 5835331 NT R.unicomis complete mitochonddal genome 4860 9967 15052 1.2 1.1OE+00 L23195.1 NT Drosophila melanogaster cytoplasmic dynein heavy chain mRNA, complete cds 4921 10028 15105 2.9 1.1OE+00 U18466.1 NT African swine fever virus, complete genome 4999 10102 15170 1.2 1.1OE+00 X78425.1 NT E.faecalls pbpS gene 92 5299 1.2 1.OOE+00 U23808.1 NT Xenopus laevis rhodopsin gene, complete eds Page 6 of 196 Table 4

108 5311 10436 1.1 1.OOE+00 D88425.1 NT Cavia cobaya mRNA for serinelthreolne kinase, complete cCis 412 5580 10840 0.7 1.OOE+00 AB021684.1 NT Marchanda polymorp.ha genes for 26S rRNA, 5S rRNA, 18S rRNA, 5.8S rRNA and 26S rRNA 562 5724 10945 1.1 11.00E+00 AJ251660.1 NT Girardia tgdna mRNA for homeodomain transjipfion factor (so gene) 661 5817 1.5 1.0015+00 AL163218.2 NT- Homo saplens chromosome 21 segment HS21C018 663 5819 1.0 11.00E+00 AF125984.1 NT Aedes aegypd mucin-liKe protein MUCJ mRNA, complete CCIS 1364 7914 1.0 1.OOE+00 X80416.1 NT V.carted Agal-CAM mRNA RNA for nonstructural polyprotein, capsid protein precursor, Plauda stall intesfine virus 1722 6845 12024 1.3 1.OOE+00 1A130065311.1 NT complete cds 1977 7534 7092 - 0-5 -1.OOE+00 P02704 - SWISSPROT PROCOLIPASE A FRCUuRSOR 2435 7534 12740 0.5 1.OOE+00 P48355 SWISSPROT DNA GYRASE SUBUNIT B 2435 12741 0.5 1,OOE+00 P48355 SWISSPROT DNA GYRASE SUBUNIT B (Serfl), survival of motor neuron protein (Smn), neuronal Mus musculus Serfl protein apoptosis Inhibitory protein-rs6 (Nalp-rs6), and neuronal apoptosis inhibitory protein-rs3 (Nalp.

2651 7740 12940 1.1 1.OOE+00 AF131205.1 NT rs3) genes, complete cds 4-DEHYDROGENASE 1 (STEROID 5-ALPHA-REDUCTASE 1) 3-OXO-5-ALPHA-STEROIL) 2846 7997 13093 3.5 1.OOE+00 P24008 SWISSPROT (SR TYPE 1) 3-OX0-5-ALPHA-STEROID 4DEHYDROGENASE 1 (STEROID 5-ALPHA-REDUCTASE 1) 2846 7997 13094 3.5_ -1.OOE+00 P24008 SWISSPROT (SR TYPE 1) 1.0 1.OOE+00 014226 SWISSPROT HYPOTHETICAL 67.9 KI) PROTEIN C6F12,08C IN CHROMOSOME 1 2938 8089 3, 3162 8311 13423 1.2 1.00IE+00 AA628453.1 EST HUMAN al26g08.sl SoaresjotaLfetus_Nb2HFL9w Homo sapiens cDNA cAone IMAGE:1032830 3277 8422 13530 1.9 11.00E+00 AF260827.1 NT similar to WID:C42138.3 CE04204 xontains element MER22 MER22 repetitive element; lpornoea batatas cysteine protease mRNA, complete ods and 6 3327 8471 13860 0.8 1.OOE+00 AF222761.1 NT Rattus norveQiicu., 3548 5299 1,2 1.OOE+00 U23808.1 NT Xenopus laevis rhodopsFn---gene, cornple cds 627 8766 1.4 1.OOE+00 AJ223816.1 NT Agaricus bispo s mRNA for tyrosinase velox cytochrome b (cytb) gene. rnitochondrial gene encoding mitochondrial Geococcyx 3683 8822 13915 -1.3 1.OOE+00 U89198.1 NT protein, complete cds Geococcyx velox cytochrome b (cytb) gene, mitochonddai gene encoding mitochondrial 3683 8822 13916 1.3 1.OOE+00 U89198.1 NT protein, complete cds Homo saplens calcium channel alphal E subunit (CACNA1 E) gene, exons 7-49, and partial 3978 9110 14192 0.9 1.OOE+00 AF223391.1 NT ods, alternatively spliced 4178 9304 0.8 1.OOE+00 8922245 NT Horno saplens hypothetical protein FLJ10139 (FILA0139), mRNA 4632 9746 5.9 1.OOE+00 Q09472 SWISSPROT EIA-ASSOCIATED PROTEIN P300 0.9 11.00E+00 U75741.1 NT Taenia ovis 45W antigen Uw4) gene, complete cds 4815 9924 HS21 C081 21 4862 9969 15054 0.9 1.OOE+00 AL163281.2 NT Horno saplen; chromosome segment N-acetytglucosaminyitransterase 111. complete cds 4951 10056 15309 9 1.00E+00 D10852.1 NT Rattus norvegicus mRNA for 51 16234 09 1.OOE+00 AJ223978.1 NT Bacillus subtilis 42.7kB DNA fraament from sA to YVQA of G-protein signallin LOCO lit mRNA, complete cds 1553 6680 11847 0.8 9.9OE-01 AF245455.1 NT - L1553 6680 11848 0.8 M9-OE-01 IAF245455.1 NT Drosophila melanogaster regulator - Drosophila melanogaster regulator of G-p complete cds Page 7 of 196 Table 4

2598 7689 12892 0,9 9.9OE-01 AL163302.2 NT Homo sapiens chromosome 21 segment HS21 Cl 02 3553 8693 1.2 9.90E-01 AF174585.1 NT Apple mosaic virus RNA 2 putative polymerase gene, complete cds 512 5676 10797 0.8 9.8OE-01 P22567 SWISSPROT AMINO-ACID ACETYLTRANSFERASE (WACETY1-GLUTAMATE SYNTHASE) (AGS) (NAGS) 5106 10202 1.0 9.70E-01 A1660384.1 EST HUMAN we62e04.xl Soarekjhymus_NHFTh Homo sapiens cDNA clone IMAGE:2345694 3' 2645 7734 12935 0.6 9.60E-01 AJ400877.1 NT Homo sapiens ASCL3 gene, CEGP1 gene, Cl lorl14 gene, Cl lorl15 gene, Cl lorl16 gene and Cl 1 orfl 7 gene 4337 9460 14548 6.8 9.6OE-01 AF197925.1 NT Bromus Inermls putative cytosolic phosphoglucomutase (pgml) mRNA, complete cds 4337 9460 14549 6.8 9.60E-01 AF197925.1 NT Bromus Inermis putative cytosolic phosphoglucomutase (pgm l) mRNA, complete cds 4355 9477 14568 1.3 9.60E-01 AW799674.1 EST HUMAN PM2-LIM0053-240300. 005412 UM0053 Homo sapiens cDNA 5083 10181 15261 0.9 9.6OE-01 7662375 NT Homo sapiens KIAA0914 gene product (K1AA0914), mRNA 3186 8335 13447 1.5 9.5OE-01 P22149 SWISSPROT IRON-REGULATED TRANSCRIPTIONAL REPRESSOR AFT1 1087 6225 11376 0.8 9.40E-01 6671685 NT Mus musculus catenin src: (Catns), mRNA 1087 6225 11377 0.8 9.40E-01 6671685 NT Mus musculus catenin src (Catns), mRNA 3165 8314 3.4 9.4OE-01 AF165990.1 NT Bartonella danidgeiae RNA polymerase beta subunit (rpoB) gene, partial cds 3181 8330 1.7 9.40E-01 AF080595.1 NT Pimpinelia brachycarpa zinc finger protein (ZFPI) mRNA, complete cds 1700 6823 1.1 9.3OE-01 AF242382.1 NT Homo sapiens phytanoA-CoA hydroMase (PHYH) gene, exon 5 2594 7686 12889 1.1 9.30E-01 BE071172.1 EST-HUMAN RCS-ST0503-271 199-01 1- BO1 BT0503 Homo sapiens cDNA 3949 9082 14162 0.8 9.3OE-01 M20219.11 NT Bovine papillomavirus type 2, complete genome 3949 9082 14163 0.8 9.3OE-01 M202119.1 NT Bovine papillomavirus type 2, complete genome 4567 9685 14779 1.3 9.30E-01 X06083.1 NT Calothrix cpcB3 and cpcA3 gene for phycoconin 3 subunits beta and alpha 5155 10250 1.5 9.30E-01 AF075615.1 NT Equus caballus microsatellite LEX013 3658 8797 13891 1.0 9.2OE-01 Z74263.1 NT S.cerevislae chromosome W reading frame ORF YD1-215c 2077 7189 0,5 9.1OE-01 8923056 NT Homo sapiens hypothetical protein FLJ20048 (FLJ20048), mRNA 3169 8318 13430 1.0 9.1OE-01 T26418.1 EST-HUMAN AB20OG8R Infant brain, LLNL array of Dr. M. Soares 1 NIB Homo sapiens cDNA clone LLAB20OG8 5' 3169 8318 13431 1.0 9.1OE-01 T26418.1 EST-HUMAN AS20OG8R Infant brain, LI- NI- array of Dr. M. Soares 1 NIB Homc sapiens cDNA clone LLAB20OG85' 4310 9433 14523 0.9 9.1OE-01 U68172.1 NT Rattus norvegicus mudn (MUC2) gene, partial cds 1285 6415 11578 4.8 9.OOE-01 R02285.1 EST-HUMAN ye85e12.sl Soares fetal liver spleen 1 NFLS Homo sapiens cDNA clone IMAGE:1 24558 X similar to gb:K03002 60S RIBOSOMAL PROTEIN L32 (HUMAN); 3170 8319 13432 0.9 9.OOE-01 7661625 NT Homo sapiens DKFZP564M2423 protein (DKFZP564M2423), mRNA 4282 9407 14491 2.4 9.OOE-01 AF09981 0.1 NT Homo sapiens neurexin Ill- alpha gene, partial cds 4919 10026 15104 1.5 9.OOE-01 U84903.1 NT Mus musculus L23 mitochonddalrelated protein (L23mrp) gene, complete cds 4945 16050 15121 0.8 9.OOE-01 AF017729,1 NT Oryclolagus cuniculus Raffil (RAD51) mRNA, complete cds 1064 6202 11356 0.7 8.8OE-01 AE001358.1 NT Chlamydia trachomatis section 85 of 87 of the complete genome 1064 6202 11357 0.7 8.8OE-01 AE001358.1 NT Chlamydia trachomads section 85 of 87 of the complete genome 3988 9120 14204 1.5 8.8OE-01 AF079764.1 NT Drosophila melAnogaster enhancer of polycomb (E(Pc)) mRNA, complete cds 4442 9562 14658 3.3 8.80E-01 026350 SWISSPROT PUTATIVE F420-DEPENDENT NADP REDUCTASE 457 5623 10750 0.5 8.70E-01 AF106953.2 NT Homo saplens SOSI (SOS1) gene, partial cds 2353 7455 12662 1.1 8.7OE-01 5901893 NT apiens AT-binding transcription factor 1 (ATBF1), mRNA Page 8 of 196 Table 4

2845 7996 13092 4.6 8.70E-01 AA595863.1 EST HUMAN nnOSW.sl NC CGAP_Pr4.1 Homo sapiens cDNA done IMAGE: 1076877 4938 10044 2.5 8.70E-01 AF121970.1 NT Pseudomonas aeruginosa topolsomerase (top), putative transcriptional regulatory protein OhbR (ohbR), ortho-halobenzoate 1,2-dioxygenase beta-ISP protein OhbA (ohbA), OhbC (ohbC), ortho-halobenzoate 1,24oxygenase alpha-ISP protein OhbB (ohbB), and put> 466 5631 0,6 8.6OE-01 X17012.1 NT Rat IG1211 gene for Insulin-like growth factor 11 840 5989 11150 1.2 8.60E-01 W69089.1 EST HUMAN zd44e03xl Soares_fetaLboarLNbHH1 9W Homo saplens cDNA done WAGE:343516 V 2224 7331 12544 1.0 8.60E-01 4503210 NT Horno, saplens cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1 (CYP27A1 b) mRNA 3568 8707 13805 0.8 8.60E-01 AL161565.2 NT ArabidopsIs thallana DNA chromosome 4, config fragment No. 65 3730 8867 13959 1.3 8.6012-01 U49724.1 NT Drosophila melanogaster merlin (Dmedin) mRNA, complete cds 5046 10146 15224 1.0 8.6OE-01 AE002239.2 NT Chlamydophila pneumonia@ AR39. section 67 of 94 of the complete genome 3930 9064 14151 3.1 8.50E-01 A1215419.1 EST-HUMAN qhl 1b01.xl Soares NFGBC_SI Horno, sapiens cDNA done IMAGE:1844329 3' 2006 7120 12321 1.1 8.40E-01 AA078112.1 EST-HUMAN 7HI4C04 Chromosome 7 HeLa cDNA Library Horno sapiens cDNA done 7H14C04 4108 9234 14317 0.8 8.40E-01 AF143509.1 NT Mus musculus NK cell receptor 2B4 gene, promoter region and partial ods 5045 10145 15223 1.0 8.40E-01 AA078112.1 EST HUMAN 7HI4C04 Chromosome 7 HeLa cDNA Library Homo saplens cDNA clone 7H14C04 724 5878 11018 0.8 8.30E-01 M93437,11 NT Thermus thermophilus cytochrome c-552 (cycA) and CycB (cycB) genes, complete cds 3056 8207 13306 2.6 8.30E-01 AL161506.2 NT Arabidopsis thallana DNA chromosome 4, oondg fragment No. 18 3739 8876 13966 1,0 8.30E-01 AB010879.1 NT Nfoodana tabacum mIRNA forchloroplast dbosomal protein L10, complete cds 4628 9742 1.9 8.30E-01 AF083221.1 NT Fugu rubripes putative neurotransmitter receptors, YDR140w homolog, and glycinamide dbonudeodde transformylase (GART) genes, complete ods 4917 10024 15102 1.1 8.30E-01 U46918.11 NT Cants famillads MI-IC DLA Class 11 DIRB pseudogene DRI212 4917 10024 15103 1.1 8.30E-01 U469116.1 NT Cants famillads; MI-IC DLA Class 11 DRB pseudogene DIRB2 5177 10024 15102 1.0 8.30E-01 U46916.11 NT Cants famillads MI-IC DLA Class 11 DRB pseudogene DRB2 5177 10024 15103 1.0 8.30E-01 U46916.1 NT Cants familiarts MI-IC DLA Class 11 DRB pseudogene DR82 2043 7156 0.5 8.20E-01 AF145589.1 NT Mus musculus trophinin (Tnn) gene, complete cds 2646 7735 1.1 8.20E-01 AW376990.1 EST-HUMAN IL3-CTO219-161199-031-CO8 CTO219 Homo saplens cDNA 4308 9431 14520 1.2 8.20E-01 7662295 NT Homo saplens KIAA0769 gene product (K1AA0769), mIRNA 2731 7815 1.3 8.1012-01 AF191839.1 NT Mus musculus TANK binding kinase T13K11 (Tbkl) mIRNA, complete cds 3412 8554 13662 2.8 8.1OE-01 AF055066.1 NT Homo saplens MI-IC dass 1 region 3412 8554 13663 2.8 8.1OE-01 AF055066.1 NT Homo saplens MI-IC class 1 region 5364 1.0 8.0012-01 AJ271510.1 NT Staphyloooccus aurcus pardal pta gene for phosphate actyltransferase allele 15 285 5472 10602 1.3 8.OOE-01 AJ132772.1 NT Bos taurus futh and rtlf genes 763 5916 11063 1.1 8.OOE-01 AF208153.1 NT Drosophila americana texana strain LP97,09 transformer (tra) gene. tra-D_am.01 allele, partial cds 1603 6730 11902 1,2 8.OOE-01 Z54199.1 NT Lesculentum DNA Afisa craig encoding 1-aminocyclopropane-l-carboxyiic add oxidase 3039 81 9 2.7 8.OOE-01 A 27897.1 NT Saimid boliviensis olfactory receptor (SBO27) gene, partial ods 8418 13525 1.1 8.OOE-01 A13006193.1 NT Mus musculus gene for oviductal glywprotein, complete cds T Page 9 of 196 Table 4

3643 8782 1.8 8.OOE-01 AL162758.2 NT Neisseria meningiddis serogroup A strain Z2491 complete genome; segment 717 4432 9553 14647 5.7 8.OOE-01 X83739.2 NT G.oallus mRNA for nicotinic acetylcholine receptor (nAChR) beta 3 subunit 446 5612 10743 1.3 7.9OE-01 Dl 1476.1 NT Lymantria dis ar nuclear polyhedrosis virus gene for DNA polymerase, complete cds 698 5853 1.2 7.9012-01 AE002130.1 NT Ureaplasma urealyticum section 31 of 59 of the complete genome 1587 6713 66.0 7.9OE-01 AB040885.1 NT Homo sapiens mRNA for KIAA1452 protein. partial ods 1634 6760 1.4 7.9OE-01 U32739.1 NT Haemophilus influenzae Rd section 54 of 163 of the complete genome 2216 7324 12538 1.9 7.9OE-01 A13004816.1 NT Oryctolagus cuniculus mRNA for mitsugumin29, complete cds 2217 7325 12539 0.8 7.9OE-01 AF130459.1 NT Danio rerio Trp4-assodated protein TapIA (tapl A) mRNA, complete cds 3472 8613 13725 2.8 7.9012-01 AF228664.1 NT Gallus gallus SOX8 transcription factor (SOX8) mRNA, complete cds 4204 9329 0.9 7.9OE-01 BE263612.1 EST-HUMAN 601192033F1 NIH MGC 7 Homo sapiens cDNA done IMAGE:3535785 5' 4508 9627 14720 1.0 7.9OE-01 6753745 NT Mus musculus embigin (Emb), mIRNA 4508 9627 14721 1.0 7.9OE-01 6753745 NT Mus musculus embigin (Emb), mRNA 5075 10173 15252 0.8 7.9OE-01 Z4721 0.1 NT S.pneumonlae dexB, cap3A, p313 and cap3C genes and orfs 5075 10173 15253 0.8 7.9OE-01 Z4721 0.1 NT 8.pneumonlae dexB, caR3A. cap3B and cap3C genes and orfs 5084 10182 1.0 7.9OE-01 M29930.1 NT Human insulin receptor (allele 2) gene, exons 14, 15, 16 and 17 858 6006 0.6 7.8OE-01 Z43785.1 EST-HUMAN HSC1 KHO41 normalized Infant brain cDNA Homo sapiens cDNA clone c-1 kh04 2229 7336 12548 1.2 7.8OE-01 AW959567.1 EST HUMAN EST371637 MAGE resequences, MAGF Homo saplens cDNA 4603 9717 14810 0.8 7.8OE-01 U87305.1 NT Rattus norvegicus transmembrane receptor Unc51-11 mRNA, complete cds 138 5334 10464 2.2 7.7OE-01 AF184345.1 NT Lycopersicon hirsutum ADP-. glucose pyrophosphorylase large subunit (AGP-Ll) mRNA, complete cds 709 5863 0.6 7.7OE-01 AF050157.1 NT Mus musculus major histocompatibility locus class 11 region: major histocompatibility protein cJass 11 alpha chain (1Aalpha) and major histocompadbility protein class 11 beta chain (IEbeta) genes. complete cds; butyrophilin-like (ING9), butyrophilin-li> 772 5924 11073 0.7 7.7OE-01 P02921 SWISSPROT MELIBIOSE CARRIER PROTEIN (THIOMETHYLUALACTOSIDE PERMEASE 11) (MELIBIOSE PERMEASE) (NA+ (L1+)/MELIBIOSE SYMPORTER) (MELIBIOSE TgANSpORTEgI 2680 7767 12968 1.0 7.7OE-01 033915 SWISSPROT CITRATE SYNTHASE 3313 8458 0,8 7.7OE-01 8393408 NT Homo sapiens UDP-N-acetyl-alpha-D- galactosamine:polypeptde N acetyigalactosaminLitransferase 7 (GaINAc-T7) (GALNAC-T7), mRNA 3549 8689 13791 4.5 7.7OE-01 AFI 18085.1 NT Homo sapiens PRO1975 mIRNA,. complete ods 3722 8859 2.3 7.7OE-01 6753425 NT Mus musculus cytokine Inducible SH2contalning protein (Cish), mRNA 4297 9421 14511 2.9 7.7OE-01 AF199488.1 NT Cotumix cotumix japonica sub- spedes japonica beta-actin mRNA, partial cds 4297 9421 14512 2.9 7.7OE-01 AF1 99488.1 NT Cotumix cotumix japonica subspedes japonica beta-actin mRNA, partial cds 502 5666 0.5 7.5OE-01 AL163301.2 NT Homo saplens chromosome 21 segment HS21 Cl 01 569 5730 10847 0.8 7.5OE-01 AF020503.1 NT Homo sapiens FRA3B common fragile region, diadenosine triphosphate hydrolase (FHIT) gene,exon5 1972 7087 0.9 7.5OE-01 4505834 NT Homo sapiens polycystic kidney disease 2 (autosomal dominant) -NOTE: redefinition of symbol (P02) mRNA 3315 8460 13572 0.9 7.5OE-01 C14203.1 EST-HUMAN Cl 4203 Clontech human aorta polyA+ mRNA (#6572) Homo sapiens cDNA clone GEN 037El l W 4573 5305 10432 13.9 7.50E-01 8922672 NT Homo sapiens hypothetical protein FU10793 (FU10793), mIRNA Page 10 of 196 Table 4

1114 6251 11401 1.2 7.4OE-01 A1598146.1 EST HUMAN liar to 2295 7399 12608 1.0 7.4OE-01 ABOI 1106.1 NT tnl4b09.xl NCI-CIGAIR-Elm25 offlo sapiens cIDNA done IMAGE:2167577 Ysirn contains Alu repetitive elementcontains element MIR repetitive element, 534 protein, partial cds Homo saplens mRNA for K] cdS 3665 8804 13898 1.2 7.4012-01 AFI 12538.1 NT malva pusilla actin (Actl) MRNA, complete zi segment HS21 C046 4213 9337 14421 4.4 -7.4OE-01 AL163246.2 NT Homo saplens chromosome 4602 9716 14809 4.8 7.40E-01 BE094286.1 EST HUMAN PM3-BT0764-13050M01-c03 BT0764 Homo saplens cDNA 52 of 70) of the complete genome 4515 9634 14726 1.0 7.3OE-01 AE001166.1 NT Borrelia burgdorferl (.section transcript variant b, iRNA 7 _EP(N^ 5127 10222 1.1 7.3OE-01 5350211 NT Homo sapiens growth arrest-spedfic GAS7), lete cds 814 5964 12219 0.9 7.2OE-01 L29281.1 NT Rattus norvegicus Initiation fac 1914 7031 12718 1.3 7.2OE-01 X79140.1 NT N.tabacum Ne1F4A13 mRNA 2412 7511 13280 0,5 7.2OE-01 ABOO9605.1 NT Gallus gallus gene for melanocortin 2-receptor, complete cds 3028 8180 1,2 7.2OE-01 AF198100,1 NT Fowlpox virus, complete genome variant-specific surface protein (vsp417-6) gene, vsp417-ISIA-1 aliele, Giardia Intestinalls 3406 8548 13656 2.1 7.2OE-01 AF065606.1 NT complete cds 3736 8873 8' 2,4 7.2OE-01 AB010810.1 NT Candida albicans gene for phospholipase D, complete cds 4660 9772' r14 7 1.2 7.2OE-01 D90314.1 NT L.mesenteroldes gene for sucrose phosphorylase (EC 2.4.1.7) 5064 10162 152238 1.2 7.20E-01 AF196779.1 NT prote 5064 10162 1 7.2OE-01 AF196779.1 NT Homo sapiens transcription fictor IGHM enhancer 3, JM1 1 protein, JM4 protein,, JM55 protein, 15239 T54 protein, JMIO protein, A4 differentlation-dependent protein, triple LIM domain lproteln 66l,n' and synaptophysin genes,' co. mplete cds; and L-type calcium channel a> Homo saplens transcription factor IGHM enhancer 3. JMI 1 protein, JM4 protein, JM5 protein, T54 protein, JMIO protein, A4 differentiation-dependent protein, triple LIM domain protein 6, and synaptophysin genes complete cds; and L-type calcium channel a> Rana catesbelana mRNA for bullfrog skeletal muscle calcium release channel (ryanodine 677 5832 10963 3.5 7.1OE-01 D21070.1 NT receptor) alpha isoform(RyRl), complete cds 3024 8176 14325 1327710.8 7.1OE-01 AJ270777A NT Homo saplens partial TCF- 4 gene tor T-cell transcription factor-4, exons 15-16 4114 9240 1-4326 2.9 7.1OE-Oi 7305360 NT Mus musculus otogelin ( log), mRNA -"?2-40 2.9 7.1OE-01 7305360 NT Mus musculus otogelin (Utog), mRNA 4114 9800 14903 0.8 7.1OE-01 Z73277.1 NT S.cerevisiae chromosome Xil reading frame ORF YLIRIO5c 4688 6340 11498 1.0 7.OOE-01 AB014514.1 NT Homo haplens mRNA for KIAA0614 protein, partial cds 1209 -U-340- -11499 1.0 7-0-OE-01 AB014514.1 NT Homo sapiens mRNA for KIAA0514 protein, partial cds 1209 Soare_muidple_sderosis-2NbHMSP Homo sapiens cDNA done 2399 7499 12705 0.5 7.OOE-01 N62412.1 EST HUMAN yz73e07.sl IMAGE:288708 Ysimilar to contains Au repetitive element; Soares-multple_sderosis_2NbHMSP Homo sapiens cDNA clone 2399 7499 12706 0.5 7.OOE-01 N62412.1 EST HUMAN yz73e07.si 4989 10092 2.0 7.OOE-01 AL163301.2 NT I MAGE:288708 Y similar to contains AW repetitive element; Homo saplens chromosome 21 segment HS21 Cl 01 albIcans squalene epoxidase (CAFERG1) gene, complete cds and translational Candida 954 6100 11257 54 6.90E-01 U69674.1 NT regulator gene, partial cds 61001 Candida albicans squalene epoxidase (CARGI) gene, complete ods and translational 954 11258 5.4 6.9OE-01 U69674.1 NT - - regulator gene, partial ods Page 11 of 196 Table 4

1288 6418 11581 0.8 6.9OE-01 AA593530.1 EST HUMAN rin28a09.sl NCI CGAP_Gasl Horno sapiens cIDNA clone IMAGE:1085176 3' 3182 8331 13443 1.6 6.90E-01 AE002271.2 NT Chlamydia muridarum, section 3 of 85 of the complete genome 3341 8485 13599 2.6 6.9OE-01 6677734 NT Mus musculus rat guanine nudeodde dissociation stimulator (Rgds), mRNA Mus musculus mRNA for Immunoglobulin gamma heavy chain variable region, isolate PC 3399 8541 13649 0.9 6.9OE-01 Y17373.1 NT 2811 941 6088 11245 1.0 6.8OE-01 AF017784.1 NT Giardia Intestinalls carbamate kinase gene, complete cds aj75a05.sl Soares_parathyrolO_turnor-INbHPA Homo sapiens cDNA clone IMAGE:1402256 Ysimilar to gb:X5641 1-mal ALCOHOL DEHYDROGENASE CLASS 11 PI CHAIN (HUMAN); 2799 6724 11894 0.6 6.8OE-01 AA854475.1 ESTHUMAN 4469 9589 14685 1.3 6.8OE-01 J00762.1 NT Rat(hooded) prolactin gene: exon ill and flanks 4749 9860 14952 0.8 6.80E-01 4758521 NT Homo sapiens hevin (HEVIN) mRNA Homo saplens nuclear factor of kappa light polypeptide gene enhancer in Bcells 1 (NFKB1) 295 5481 10612 10.0 6.7OE-01 AF213884.1 NT gene, complete ods Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B- cells 1 (NFKB1) 336 5517 10642 6.7 6.7OE-01 AF213884.1 NT gene, complete ods W2g12.sl Soares_total - fetu:_Nb2HF&_gw Homo saplens cDNA done IMAGE:786310 3, 2100 7211 12419 0.6 6.7OE-01 AA451864.1 EST HUMAN similar to contains element TAR1 repetitive element; Drosophila melanogaster Mst85C gene, complete ods; NMDMC Isoform (Nmdmc) gene, complete cds, alternatively spliced; and transcription factor (Relish) gene, complete cds, 2120 7935 12440 1.3 6.7OE-01 AF186073.1 NT alternatively spliced 2966 8117 13224 3.7 6.70E-01 6678580 NT Mus musculus Wiskott-Alddch syndrome protein (Wasp), mRNA 4350 9472 14564 1.0 6.7OE-01 X74421.1 NT S.tuberosum mRNA for glucose-6- phosphate dehydrogenase 4881 9989 15070 0.9 6.7OE-01 AW0791 10.1 EST-HUMAN xa95912.xl NCI CGAP Co17 Homo saplens cDNA clone IMAGE:2574598 3' 5182 10274 15343 0.9 6.7OE-01 AJ252942.1 NT Dendroblum firnbriaturn mRNA for phosph nolpyruvate carboxylase, partial 2452 7551 12759 0.9 6.60E-01 AF075240.1 NT Homo saplens SLITI protein (SLIL2) mRNA, partial ods Homo saplens lens epithelium-derived growth factor gene, alternatively spliced, complete cds 2667 7754 12954 1.3 6.6OE-01 AF199339.1 NT Homo sapiens serna domain, seven thrombospondin repeats (type 1 and type 1 -like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A (SEIVIA5A) 3445 8587 13700 1.0 6.6OE-01 4506880 NT mRNA 3484 8625 13737 1.1 6.6012-01 AB01 1536.1 NT Homo saplens mRNA for MEW2, partial cds 3484 8625 13738 1.1 6.6OE-01 AB01 1536.1 NT Homo sapiens mRNA for MEGF2, partial cds 3608 8747 13842 3.1 6.60E-01 Y07669.1 NT C.albicans random DNA marker, 282bp Human hereditary haemochromatosis region, histone 2A-like protein gene, hereditary haemochromatosis (HLA-Hi gene, RoRet gene, and sodium phosphate transporter (NPT3) 4020 9149 0.9 6.6012-01 U91328.1 NT gene, complete cds 608 5766 10884 1.4 6.50E-01 M75140.1 NT H.vulgads Na.K-ATPase alpha subunit rnRNA, complete cds 608 5766 10885 1.4 6.50E-01 M75140.1 NT H.vulgaris Na,K-ATPase alpha subunit mRNA, complete cds 3386 8529 13636 5.1 6.5OE-01 A13041225.1 NT Mus musculus gene for Tob2, complete cds 3951 9084 14165 1.1 6.5OE-01 4504632 NT no saplens Interleukin 10 receptor, alpha (11-1 ORA) mRNA 9311 9, 4.2 ilo saRiens SPP2 gene for secreted phosphoprotein 24 precursor, exons 1-8 14392 Page 12 of 196 Table 4

4215 9339 14422 0.9 6.5OE-01 AL161539.2 NT Arabldopsis thallana DNA chromosome 4, contig fragment No. 39 4994 10097 15164 2.3 6.5OE-01 U28921.1 NT Phascolus vulgads ATPase gamma subunit mRNA, nuclear gene encoding mitochondrial protein, partial cds 5031 10131 15207 1.0 6.50E-01 4826799 NT Homo sapiens potassium inwardly- rectifying channel, subfamily J, member 5 (CNJ5) mIRNA 5175 10269 0,9 6.5OE-01 U37258.1 NT Acetobacter xylinum putative ATP binding protein delta-AwS gene, partial cds, and GDP mannose:wlloblosA-diphosphopolyprenoI alpha-mannosyitransferse gene, complete ods 252 5440 10567 1.8 6.40E-01 U48848.1 NT Drosophila melanogaster 8M dynein light chain mRNA, complete cds 3410 8552 13660 2.5 6.40E-01 U48854.2 NT Mus musculus dystroglycan 1 (DAG1) gene, exons 1 and 2 and complete ods 4389 9511 14598 0.8 6.4012-01 Y12488.1 NT M.musculus whn gene 4389 9511 14599 0.8 6.4OE-01 Y12488.1 NT M.musculus whn gene 427 5594 10728 1.5 6.3OE-01 P05228 SWISSPROT HISTIDINE-RICH PROTEIN PRECURSOR (CLONE PFI-IRP-111) 524 5688 10809 0.7 6.3OE-01 U32689.1 NT Haernophilus Influenzae Rd section 4 of 163 of the complete genome 1505 6631 11800 1.5 6.3OE-01 AA365227.1 EST HUMAN EST75935 Pineal gland 11 Homo sapiens cONA Cend similar to similar to orthodenticle related protein 1 2116 7227 12435 1.4 6.3OE-01 U81136.1 NT Shigella flexned muld-andblodc resistance locus 2534 7630 12832 1.4 6.3OE-01 U75331.1 NT Gallus gallus bone morphogenedc protein 1 (BMP1) mRNA, partial cds 2534 7630 12833 1.4 6.3OE-01 U75331.1 NT Gallus gallus bone morphogenefic protein 1 (BMPI) mRNA, partial cds 2983 8135 0.9 6.3012-01 Y17275.1 NT Lycopersicon esculentum p69a gene, complete CDS 3985 9117 14200 1.4 6.30E-01 X99675.1 NT D.melanogaster mRNA for metabotroplc glutamate receptor 4755 9866 14959 1.5 6.2OE-01 4504402 NT Homo sapiens major histoj7mpadbility complex, class 11, DO beta (HLA-DOB) mRNA 5002 10105 15173 1.0 6.2OE-01 A1587039.1 EST HUMAN tr55d08.xl NCLCGAP_Panl Homo sapiens cDNA done IMAGE:2222223 3' similar to contains element MSIR1 repetitive element; - 2345 7447 1.6 6.1OE-01 6678076 NT Mus musculus secreted addic cystelne rich jiycoprotein (Sparc), mRNA 2966 8107 1.3 6.1012-01 AF153704.1 NT Tetrahymena thermophila dynein heavy chain (DYH8) gene, partial cds 4931 10037 15109 1.0 6.1OE-01 L20427.1 NT Rattus norvegicus dihydroxypolyprenylbenzoate methyltransferase mRNA, complete cds 4931 10037 15110 1.0 6.1OE-01 L20427.1 NT Rattus norvegicus dihydroxypolyprenylbenzoate methyltransferase mRNA, complete ods 486 5651 10775 0.9 6.OOE-01 D87675.1 NT Homo sapiens DNA for amyioid precursor protein. complete ods 549 5712 0.9 6.OOE-01 5802999 NT Homo sapiens adaptor-related Rrotein complex 3, mu 2 subunit (CLA20), mRNA 1339 6467 11635 0.6 6.OOE-01 AF065253.1 NT Human respiratory syncydal virs strain CH93-53b attachment protein (G) gene, complete cds 3744 8881 13970 1.0 6.OOE-01 A.1233396.1 NT Viral hemorrhagic septicemia virus N, P, M, G, NY, L genes, French strain 07.71 984 6129 11284 1.3 5.9OE-01 U32701.1 NT Haemophilus influenzae Rd section 16 of 163 of the complete genome 2354 7456 12663 2.3 5.9012-01 A1859996,1 EST HUMAN wm22f01.xl NCI_PGAP_Ut4 Homo saplens cDNA done IMAGE:2436697 3' 3232 8380 13486 4.9 5.9OE-01 AL163267.2 NT Homo saplens chromosome 21 segment HS21C067 3232 8380 13487 4.9 5.9OE-01 AL163267.2 NT Homo saplens chromosome 21 segment HS21C067 4129 9255 4.1 5.9OE-01 AF162756.1 NT Rattus norveglcus ceneyJn 2 mRNA, partial ods 1867 6985 12169 0.5 5.8OE-01 SWISSPROT SIM1 PROTEIN Page 13 of 196 Table 4

Page 14 of 196 3401 8543 13651 2.0 5.8OE-01 AF154923.1 NT Mycoplasma arthriddis strain H39 putative gdhesin MAA1 (meal) gene, complete cds 3900 9035 14127 1.0 5.8OE-01 7662ES-9 NT Homo saplens KIAA0335 gene product (K1AA0335), mRNA 4413 9533 14j622 2.8 5.8012-01 ABOO9077.1 NT Vigna radiata mRNA for proton pyrophosphatase, complete cds 4690 9802 1.0 5.8OE-01 AF1 10846.1 NT Megasella scalads sex-lethal hornolog (MegsxJ) gene, partial cds, alternatively spliced products 764 5917 11064 2.0 5.70E-01 D83536.2 NT Escherichla coli genomic DNA. (4. 1 - 6.1 min) 1840 7928 12144 0.9 5.70E-01 AB024336.1 NT Mus musculus mRNA for membranebound transferrin-like protein p97, complete cds 1840 7928 12145 0.95.70E-01 AB024336.1 NT Mus musculus mRNA for membrane- bound transferrin-like protein p97, complete cds 3460 8601 2.4 5.7OE-01 AB033503.1 NT Populus euramericana peacs-2 mRNA for 1-aminocycJopropane-l-carboxylate synthase, complete cds 3829 8966 14065 1.7 5.70E-01 AF01 1581.1 NT Horno sapiens T cell receptor beta chain (BV6S72-BJ1Sl) mRNA, partial cds 5201 10292 15359 2.2 5.70E-01 U78517.1 NT Rattus norvegicus cAMP- regulated guanine nucleofide exchange factor 11 (cAMP-GEF11) mRNA, partial cds 3318 8463 13575 1.2 5.6OE-01 AB0118283.2 NT Homo sapiens mIRNA for KIAA0740 Erotein, partial cds 3318 8463 13576 1.2 5.60E-01 A13018283.2 NT Homo sapiens mRNA for KIAA0740 protein, partial cds 3808 8945 14041 0,8 5.6OE-01 AL161501.2 NT Arabidopsis thaliana DNA chromosome 4, config fragment No. 13 4146 9272 14350 0.8 5.6OE-01 D83135.1 NT Chicken-T-13P gene, exon8, complete ods 4726 9838 14930 0.8 5.6OE-01 7330334 NT Homo sapiens chlodde intracellular channel 4 like (CLIC4L), mRNA 1193 6325 11481 1.1 5.50E-01 8393912 NT Rattus noryegicus Propiony! Coenzyme A carboxylase, beta polypeptide (Pccb), mRNA 2668 7755 12955 1.0 5.5OE-01 P03341 SWISSPROT GAG POLYPROTEIN [CONTAINS: INNER COAT PROTEIN P12; CORE PROTEIN P15; CORE SHELL PROTEIN P30; NUCLEOPROTEIN P10] 2668 7755 12956 1.0 5.5OE-01 P03341 SWISSPROT GAG POLYPROTEIN [CONTAINS: INNER COAT PROTEIN P12; CORE PROTEIN P15; CORE SHELL PROTEIN P30; NUCLE6PROTEIN P10] 2888 8039 13140 1.3 5.50E-01 5902085 NT Homo sapiens superkiller viralicldic activity 2 (S. cerevisiae homolog)41ke (SKIV2L), mRNA 3027 8179 1.4 5.5OE-01 H4621 9.1 EST HUMAN yo18a10.sl Soares adult brain N2b51-11355Y Homo sapiens cDNA clone IMAGEA78266 3, 3196 8345 13458 3.1 5.5OE-01 AF227240.1 NT Rabbit oral Rapiltomavirus, complete genome 3634 8773 13867 1.3 5.5OE-01 P48755 SWISSPROT FOS-RELATED ANTIGEN-1 139 5335 10465 1.3 5.4OE-01 7657266 NT Homo saplens KIAA0929 protein Msx2 interacting nuclear target (MINT) homolog (K1AA0929). mRNA 139 5335 10466 1.3 5.4OE-01 7657266 NT Homo sapiens KIAA0929 protein Msx2 Interacting nuclear target (MINT) homolog (K1AA0929), mRNA 570 5731 10848 0.9 5.40E-01 AF232006.1 NT Pseudomonas syringae pv. tomato strain DC3000 AvrE (avrE), HrpW (hrpW), and GstA (gstA) genes, complete cds; and unknown genes 570 5731 10849 0.9 5.40E-01 AF232006.1 NT Pseudomonas syringae pv. tomato strain DC3000 AvrE (avrE), HrpW (hrpW), and GstA WstA) gene, complete cds; and unknown genes 1250 6379 11538 0.8 5.4OE-01 AW896087.1 EST HUW QV4.NNO045:570400-160-c04 NNO040 Homo sapiens cDNA 2059 7171 1.0 5.40E-01 AE002247.2 NT Chlamydophila pneumonlae AR39, section 74 of 94 of the complete genome 2208 7317 12530 0.8 5.4OE-01 AJ276682.1 NT Drosophila mefanogaster mRNA for 15,19 beta carotene dioxygenase (beta-diox gene) Table 4

505 5669 10792 0.7 5.3OE-01 AF019413.1 NT Homo sapiens HLA class Ill region containing tenascin X (tanascin-X) gene, partial cds; cytochrome P450 21-hydroxylase (CYP21B), complement component G4 (C48) G1 1, helicase (SK12W), RD, complement factor B (80, and complement component C2 (C2) genes,> 2093 7204 12409 0.9 5.3OE-01 AF113919.1 NT Brassica oferacea var. capitata phospholiease D2 (PLD2) gene, comelete cds 2093 7204 12410 0.9 5.30E-01 AF113919.1 NT Brassica oleracea var. capitata phospholipase D2 (PLD2) gene, comelete ods 2332 35 12643 0.9 5.30E-01 4506210 NT Horno sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 3 (PSMC3) mRNA 2755 7839 13040 3.0 5.3OE-01 4506328 NT Homo sapiens protein tyrosine phosphatase, receptor-type, zeta polypepfide 1 (PTPRZ1) mRNA 2755 7839 13041 3.0 5.30E-01 4506328 NT Homo sapiens protein tyrosine phosphatase, receptor-type, zeta polypepfide 1 (PTPRZ1) mRNA 3205 8353 13463 2.9 5.3012-01 AF087658.1 NT Homo sapiens secreted C-type lectin precursor (I-SI-CL) gene, complete cds 3919 9053 2.6 5.3OE-01 M62977.1 NT Xenopus laevis LDL receptor-1 gene, Wflank 4117 9243 1.3 5.3OE-01 U39687.1 NT Mycoplasma genitallum section 9 of 51 of the complete genome 799 5950 11100 3.9 5.2OE-01 L20770.1 NT Drosophila melanogaster helix- loop-helix mRNA, complete cds 1148 6283 11436 2.6 5.2OE-01 Q9WV30 SWISSPROT NUCLEAR FACTOR OF ACTIVATED T CELLS 5 (T CELL TRANSCRIPTION FACTOR NFAT5) (NF-AT5) (REL DOMAIN-CONTAINING TRANSCRIPTION FACTOR NFAT5) 1174 6308 11462 1,0 5.20E-01 AF224492.1 NT Horno sapiens phosphollpid scramblase 1 gene, complete cds 1843 6961 1.8 5.20E-01 A1.163285.2 NT Horno sapiens chromosome 21 segment HS21C085 2099 7210 12418 1.0 5.2OE-01 AB018283.2 NT Homo sapiens mRNA for KIAA0740_protoin, partial ods 3081 8232 13330 1.9 5.20E-01 U65942,1 NT Chlarnydophila abortus strain S2613 POMP91A and POMP90A precursor, genes, complete cds 3199 8348 1.2 5.20E-01 D73443.1 NT Azotobacter lvinelandll icd gene for lsocitrate dehydrogenase, complete cds 3359 8502 1.8 5.2OE-01 AL1 16780.1 NT SoMs dnerea strain T4 cDNA library under conditions of nitrogen deprivation 3397 8539 13646 1.9 5.20E-01 AA984165,1 EST HUMAN am77905.sl Stratagene schizo brain S1 1 Homo sapiens cDNA clone IMAGE, 1616504 3, 3580 8719 1.1 5.2OE-01 AF020269.1 NT Medicago sadva chloroplast rnalate dehydrogenase precursor (plmdh) mRNA. nuclear gene encoding chloroplast protein. complete ods 3582 8721 13819 1.1 5.20E-01 U82671,2 NT Homo saplens chromosome Xq28 melanoma antigen family A2a (MAGEA2A),.melanoma antigen family A12 (MAGEA1 2), melanoma antigen family A2b (MAGEA2B), melanorna antigen family A3 (MAGEA3), caltractin (CALT), NAD(P)H dehydrogenase-like protein (NSDHL), and Li> 4949 10054 1.3 5.2OE-01 7106444 NT Mus musculus vanilloid receEtor-like protein 1 (Vdl), mRNA 601 5759 10879 0.6 5.1OE-01 M58509.1 NT Human adrenodoWn re5uctase gene, exons 3 to 12 632 5791 10913 1.1 5.1OE-01 AJ233944.1 NT Polyanglurn vitellinurn _(. strain PI W1) 16S rRNA gene 632 5791 10914 1.1 5.1OE-01 AJ233944.1 NT Polyanglum vitellinurn (strain PI W1) 16S rRNA gene 1632 6758 1.1 5.1OE-01 X87885.1 NT R.norvegicus mRNA for mammalian fusca protein 3984 9116 14199 3.8 5.1OE-01 A1858495.1 EST-HUMAN wt39bi 2.xl NCt_pGAP_Utl Horno saplens cDNA done IMAGE:2427263 3' 4094 9220 14303 2.9 5.1OE-01 P96380 SWISSPROT TRANS RIPTION-REPAIR COUPLING FACTOR (TRCF) 2087 7199 12403 1.4 5.OOE-01 4885552 NT Homo sapiens postmelodc segregation Increased 2-like 9 (PMS2L9), niRNA Page 15 of 196 Table 4

2087 7199 12404 1.4 5.OOE-01 4885552 NT Horno saplens postmelotic segregation increased 2-like 9 (PMS2L9), mRNA 2097 7208 12414 1.3 5.OOE-01 AF008210.1 NT Buchnera aphidicola genomic fragment containing (chaperone Hsp60) groEL ' DNA biosynthesis Initiating protein (dnaA), ATP operon (atpCDGAHFEB), and putative chromosome replication protein (gidA) genes, complete cds; and termination factor Rho (rho) gene> 2097 7208 12415 1.3 5.OOE-01 AF00821 0.1 NT Buchnera aphidicola genomic fragment containing (chaperone Hsp60) groEL, DNA blosynthesis initiating protein (dnaA), ATP operon (atpCDGAHFEB), and putative chromosome replication protein (gidA) genes, complete cds; and termination factor Rho (rho) gene> 2543 7639 12839 0.9 5.OOE-01 U50730.2 NT Human cyclin-dependent kinase 2 (cdk2) gene, 5' promoter region 2543 7639 12840 0.9 5.OOE-01 U50730.2 NT Human cyclin-dependent kinase 2 (cdk2) gene, Vpromoter region 3688 8826 13920 0.8 5.OOE-01 U55574.1 NT Mus musculus anfi-DNA lmmunoglobulin light chain lgM mRNA, antibody 363p. 138, partial cds 3797 8934 14027 3.4 5.OOE-01 AB033010.1 NT Homo sapiens mRNA for K1AA1 184 protein, partial cds 1864 6982 12166 1.4 4.9OE-01 U40869.1 NT Cavia porcellus pulmonary surfactant protein A (SP-a) mRNA, complete cds 2111 7222 12431 1.1 4.8OE-01 L01652.1 NT Human ventricular myosin light chain 2 gene, seven exons 4577 9362 1.1 4.8OE-01 4504850 NT Homo sapiens potassium channel, subfamily K, member 5 (TASK-2) (KCNK5) mRNA, and translated products 1950 7067 12263 0.8 4.7012-01 X76536.1 NT S.tuberosurn L. (Desiree) PHA1 mRNA 3674 8813 13907 1.3 4.6OE-01 AW818638.1 EST-HUMAN RC1 -ST0278-040400-01 8- b06 ST0278 Homo sapiens cDNA 5087 10185 1.0 4.6OE-01 M11267.1 NT Bovine steroid 21-hydroxylase gene (12-450-c211) gene, complete ods 965 6110 11266 1.0 4.5OE-01 AA249416.1 EST HUMAN J3550.seq.F Human fetal heart, Lambda ZAP Express Homo sapiens cDNA 5' 1847 6965 12150 1.3 4.5OE-01 AB033078.1 NT Homo sapiens mRNA for KIAA1252 protein, partial cds 1847 6965 12151 1.3 4.5OE-01 AB033078.1 NT Homo sapiens mRNA for K1AA1 252 protein. partial cds 1869 6987 12171 0.6 4.5OE-01 AE001931.1 NT Deinococcus radiodurans R1 section 68 of 229 of the complete chromosome 1 1869 6987 12172 0.6 4.5OE-01 AE001931.1 NT Deinococcus radiodurans R1 section 68 of 229 of the complete chromosome 1 2841 7992 13090 4.9 4.5OE-01 AA677086.1 EST HUMAN zj55d02.sli Soares- fetal-liver-spicen-1 NFILS-S1 Homo sapiens cDNA clone IMAGE:454179 3' 3275 8420 13528 4.0 4.5OE-01 005793 SWISSPROT BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN PRECURSOR (HSPG) (PERLECAN) (PLC) 3331 8475 13588 1.1 4.5OE-01 AF126378.1 NT Mus musculus DNA polymerase epsilon catalytic subunit (Pole) gene, exons 2 through 12 3942 9075 1.4 4.5OE-01 Q28247 SWISSPROT COLLAGEN ALPHA fi(IV) CHAIN 3982 9114 14197 1.1 4.5OE-01 A1708908.1 EST-HUMAN as95e09.xl Barstead aorta HPI-RI36 Homo sapiens cDNA done IMAGE:2353480 3' 4085 9212 4.0 4.5OE-01 AW873495.1 EST HUMAN ho60g02.xl Soares NFL T GBC S1 Homo sapiens cDNA done IMAGE:3041810 X 1991 7107 0.9 4.4OE-01 6680503 NT Mus musculus Integral membrane- associated protein 1 (itmapl), mRNA 2340 7442 12650 1.3 4.4OE-01 P49765 SWISSPROT VASCULAR ENDOTHELIAL GROWTH FACTOR B PRECURSOR (VEGF-B) (VEGF RELATED FACTOR) 3274 8419 13526 1.0 4.4OE-01 AF058790.1 NT Rattus norvegicus SynGAP-b mRNA, complete ods 3274 8419 13527 1,0 4.4OE-01 AF058790.1 NT Rattus norvegicus SynGAP-b mRNA, complete cds 92671 4141 1.3 4.4OE-01 BE378707.1 EST HUMAN 601237139F1 NII-LMGQ_44 Homo sapiens cDNA done IMAGE:3609393 5' Page 16 of 196 Table 4

4464 9584 8.5 4.4OE-01 AL1 15324.1 NT Botrytis dnerea strain T4 cDNA library under conditions of nitrogen deprivation 4924 10031 0.9 4.4OE-01 BE141396.1 EST-HUMAN MRO-HT0078-131299-007-g05 HT0078 Homo sapiens cDNA 405 5573 10710 0.7 4.3OE-01 AF155218.1 NT CallithrixJacchus MWILW opsin gene, upstream flanking region 405 5573 10711 0.7 4.3OE-01 AF155218.1 NT Callithrix jacchus MWILW opsin gene, upstream flanking region 961 6106 11264 0.7 4.3OE-01 A1281909.1 EST-HUMAN qt82d03.xl NCI_CGAR--- Co14 Homo sapiens d3NA done IMAGE:1961765 Ysimilar to contains Alu repefitive element; 1585 6711 11882 1.1 4.3OE-01 AW866550.1 EST-HUMAN QV4-SNO024-200400-183- b01 SNO024 Homo saplens cIDNA 2843 7994 1.0 4.3OE-01 AW935269.1 EST HUMAN CM2-DT0003-010200-077-c01 DT0003 Homo sapiens cDNA 3022 8174 13274 0.9 4.3OE-01 AW999477.1 EST HUMAN MRO-BN0070-270300-008- 904 BN0070 Horno sapleris cDNA 3221 8369 1.5 4.3OE-01 AE000698.1 NT Aquifax aeolicus section 30 of 109 of the complete genome 4059 9186 14269 1.2 4.3OE-01 J00306.1 NT Human somatostatin 1 gene and flanks 4138 9264 14345 1.1 4.3OE-01 A13028026.1 NT Nicodana tabacurn mRNA for granule-bound starch synthase, pardal cds 4306 5573 10710 1.0 4.3OE-0 AF155218.1 NT Callithrix lacchus MWILW opsin gene, upstream flanking region 4306 5573 10711 1.0 4.3OE-01 AF1 55218,1 NT Callithrix jacchus MWILW opsin gene, upstream flanking region 4875 9982 1.1 4.3OE-01 AL161502.2 NT Arabidopsis thaliana DNA chromosome 4, contig fragment No. 14 5017 10119 15191 2.1 4.3OE-01 Y15839.1 NT Cochilobolus heterostrophus pkcl, fatl genes 1335 7913 11631 1.0 4.2012-01 Q39102 SWISSPROT CELL DIVISION PROTEIN FTSH HOMOLOG PRECURSOR 1904 7022 0.9 4.2OE-01 AA761653.1 EST HUMAN nz24a09.sli ISICI_PGAP GCBI Homo sapiens cIDNA done IMAGE:1 288696 3, 3558 8697 13795 4.8 4.2012-01 AE003947.1 NT - Xylella fastidlosa, section 93 of 229 of the complete genome 3585 8724 13820 1.1 4.2OE-01 A1280338.1 ESTHUMAN Q94b011.xl Soares NhHMPu S1 Horno sapiens cONA done IMAGE:1879945 3' 3803 8940 14035 1.0 4.2OE-01 AW835527.1 EST-HUMAN QVO-LT001 5-180200-127- h01 LT0011 5 Homo sapiens cDNA 4545 9664 3.6 4.2012-01 BE073574.1 EST-HUMAN RC5-BT0559-020300-013-E06 BT0559Horrio sa lens cIDN 4599 9713 14805 5.0 4.2OE-01 AA534093.1 EST-HUMAN nj69h01.sl NCI_PGAIR - Pr10 Homo sapiens cDNA done IMAGE:997777 similar to gb:M33600 HLA CLASS 11 HISTOCOMPATIBILITY ANTIGEN, DR-1 BETA CHAIN (HUMAN); 4671 9783 14882 3.1 4.2OE-01 R13467.1 EST - HUMAN yf77e01.rll Scares Infant brain 1 NIB Homo sapiens cDNA done IMAGE:28278 5' 1078 6216 11367 0.6 4.1OE-01 A1905481.1 EST HUMAN RC-BT091 -210199-142 BT091 Homo saplens cIDNA 1592 6718 11888 1.0 4.1OE-01 A1905949.1 EST_HUMAN PM-BT103-27049MB4 BT103 Homo sapiens cIDNA 2678 7765 12966 0.6 4.1OE-01 7705283 NT Homo sapiens anaphase-prornoting complex subunit 7 (APC7), mRNA 2910 8060 13165 1.8 4.1OE-01 AL161536.2 NT Arabidopsis thatiana DNA chromosome 4, config fragment No. 36 2910 8060 13166 1,8 4.1OE-01 AL161536.2 NT Arabidopsts thallana DNA chromosome 4, dondg fragment No. 36 3263 8410 13517 1.1 4.1OE-01 AA906344.1 EST-HUMAN o194b08.sl Soares_NIFL T GBQ_SI Homo sapiens cDNA done IMAGE:1505943 3' 4177 9303 14384 2.6 4.1OE-01 AJ249207.1 NT Rhodococcus sp. AD45 isoG, IsoH, isol, isoJ, isoA, isoB, IsoC, isol), isoE and isoF genes 4208 9333 1.1 4.1OE-01 AA909257.1 EST-HUMAN orn33d02.sl Soares NFLjr_GBC- S1 Homo sapiens cDNA done JMAGE:1542819 3' 4373 9495 0.8 4.1OE-01 R41726.1 EST-HUMAN ygl 1b01s11 Scares Infant brain 1NIB Horno saplens cDNA done IMAGE:31814 3' 5185 10277 0.9 4.1OE-01 Z99124.1 NT Bacillus subdils complete genome (section 21 of 2l): from 3999281 to 4214814 1023 6162 11315 1.3 4.OOE-01 8404656 NT Laqueus rubellus mitochonddon, complete genome 1316 6445 11611 1.0 4.OOE-01 AF203478.1 NT Drosophila melanogaster Daimatian (dmt) mRNA, complete cds 1469 6596 1.5 4.OOE-01 6679258 NT Mus musculus platelet derived growth factor receptor, beta polypeptide (Pdgfrb), mRNA Page 17 of 196 Table 4

1960 7931 12274 1.2 4.OOE-01 Z96933.1 NT Ascobolus Immersus masc2 gene 1960 7931 12275 1.2 4.OOE-01 Z96933.1 NT Ascobolus Immersus masc2 gene 2774 5332 10463 1.1 4.OOE-01 6678490 NT Mus musculus ubiquifin-protein ligase e21 componen n-recognin (Ubrl), mRNA 2939 8090 13197 2.2 4.OOE-01 AL163280.2 NT Horno sapiens chromosome 21 segment HS21 C080 2939 8090 13198 2.2 4.OOE-01 AL163280.2 NT Horno saplens chromosome 21 segment HS21C080 3637 8776 13871 1.6 4.OOE-01 AF068903.1 NT Streptococcus pneumonlae Y1IC (y1IC), Y111) (y]ID), penicillin-binding protein 2x (pbp2x), and undecaprenyl-phosphate-UDP-MurNAc,pentapepdde phospho-MurNAc-pentapeptide transferase (mraY) genes, complete cds 3755 8893 13983 3.2 4.OOE-01 AJ277511.1 NT Ovis arles pardal JD2 gene for T cell receptor delta chain QCWD-J2), exon 1 3755 8893 13984 3.2 4.0OE-011 AJ277511.1 NT Ovis ades partial J132 gene for T cell receptor delta chain (TCIRDJ2), exon 1 4712 9824 7.3 4.OOE-01 Q31849 SWISSPROT NADH-PLASTOQUINONE OXIDOREDUCTASE CHAIN 5, CHLOROPLAST 227 5418 10539 0.5 3.9OE-01 AW352188.1 EST HUMAN CM4-HT01 36-150999- 014409 HT01 36 Homo sapiens cDNA 1356 6484 11651 0,8 3.9OE-01 AF206618.1 NT Gorilla gorilla carboxyl-ester lipase (CEL) gene, complete cds 2605 7695 12899 1.3 3.9OE-01 AB03301 9.1 NT Horno sapiens mRNA for K1AA1 193 protein, partial cds 2673 7760 12959 2.2 3.9OE-01 X82032.1 NT H.sapiens B-myb gene 2673 7760 12960 2.2 3.9OE-01 X82032.1 NT H.sapiens 8-myb gene 3058 8209 13308 3.6 3.9OE-01 AJ225896.1 NT Sinorhizoblum melilod e91, syrB2, genes and orf3 154 5350 2.5 3.8OE-01 7019488 NT Horno sapiens protein kinase PKNbeta (pknbeta), mRNA 805 5956 11109 0.7 3.8OE-01 AJ277435.1 NT Olive latent ringspot virus genomic RNA for polyprotein gene 848 5997 0.7 3.8OE-01 AJ277435.1 NT Olive latent ringspot virus genomic RNA for polyprotein gene 1827 6946 1.2 3.8OE-01 AE003870.1 NT a, section 16 of 229 of the complete genome 2521 7617 12818 1.2 3.8012-01 AB026898.1 NT Homo saplens DNA, DLEC1 to ORCTL4 gene region, section 112 (DLEC1, ORCTI-3, ORCTL4 genes, complete cds) 2524 7620 12821 0.9 3.8OE-01 AF214117.1 NT Arabidopsis thaliana putative c-myb-like transcription factor (MY133R-3) mRNA, complete cds 2591 7948 12884 1.6 3.8OE-01 6678002 NT Mus musculus solute carrier family 1, member 6 (Sicla6), mRNA 2972 8123 0.9 3.8OE-01 AJ251057.1 NT Human Immunodeficiency virus type 1 complete genome (isolate 98SE-MP1213) 3010 8162 13264 2,0 3.8OE-01 AF043383.1 NT Plouronectes americanus aminopepfidase N (ampN) gene, partial cds 3438 8580 13692 7.8 3.8OE-01 AL161518.2 NT Arabldopsis thallana DNA chromosome 4, condg fragment No. 30 3494 8635 0.8 3.8OE-01 A1807219.1 EST HUMAN wf38b112.xl Soarei_NFLjr_GBC_SI Homo saplens cDNA cJone IMAGE:2357855 3, 3506 8635 0.9 3.8OE-01 A1807219.1 EST HUMAN wf38b12.xl Soare_NFL T GBC S1 Homo saplens cDNA clone IMAGE:2357855 3' 3841 8977 14077 0.9 3.8OE-01 6754095 NT Mus musculus general transcripfion factor 111 (Gtf21), mRNA 2131 7241 12449 1.2 3.7OE-01 AF162061.1 NT Capnlomyces stellatus beta- tubulin (btub) gene, partial cds 2431 7530 12735 3.6 3.7OE-01 AB037831.1 NT Homo saplens mRNA for KIAA1410 protein, partial ods 3414 8556 13665 9,5 3.7OE-01 AF056336.1 NT Danio redo bone morphogenefic protein 4 precursor (13M134) gene, complete cds 4136 9262 14344 6.6 3.7OE-01 A1218707.1 EST HUMAN ok39c07.xl Soares - NSF:_F8-9W_07_PkP_Sl Homo sapiens cDNA clone IMAGE:1510188 3 4225 9349 14430 1.5 3.7OE-01 AW878037.1 EST HUMAN MR3-OT0007-080300-104- b02 OT0007 Homo sapiens cDNA 4292 9416 14506 3.3 3.7OE-01 AE002408.1 NT Neissefla meningifidis serogroup B strain MC58 section 50 of 206 of the complete genome 979 6124 2.4 3.6OE-01 U89241.1 NT Human mibp gene, partial cds Page 18 of 196 Table 4

* 1292 6421 11586 0.9 3.6OE-01 T80255.1 EST_HUMAN vd03e05xl Soares infant brain 1 NIB Horno sapiens cDNA done IMAGE:24443 5' 1292 6421 11587 077-60E-01 T80255.1 EST-HUMAN yA03e05.rl Soares Infant brain 1I NIB Horno, sapiens cDNA clone IMAGE:24443 S' 1874 6992 12177 2.2 3.6012-01 AW590184.1 EST HUMAN hg33f02.xl NCI CGAP GC6 Horno sapiens cDNA done IMAGE:2947419 3, 1874 6992 12178 2.2 3.60E-01 AW590184.1 EST-HUMAN hg33f02.xl NCI CGAP_GC6 Horno sapiens cDNA clone IMAGE:2947419 3' 1908 7025 12214 2.2 3.6OE-01 AF216207.1 NT Mus musculus dbosomal protein S19 (Rps19) gene, complete cols 2007 7121 1.1 3.6OE-01 AF056927.1 NT Rattus norvegicus repeat element associated vAth the Rasgrfl gene 2223 7330 1.0 3.6OE-01 A13002321.1 NT Human mRNA for KIAA0323 gene, partial cds 2341 7443 0,9 3.6OE-01 X76725.1 NT P.irregulare (P3804) gene for actin 2437 7536 12743 0.6 3.6OE-01 AW812033.1 EST HUMAN RCS-ST0171-181099-011- 907 ST0171 Homo sapiens cIDNA 2589 7682 12882 0.8 3.6OE-01 P24206 SWISSPROT PROTEIN-L-ISOASPARTATE 0METHY1-TRANSFERASE (PROTEIN-BETA-ASPARTATE METHYLTRANSFERASE) (PIMT) (PROTEIN L-ISOASPARTYL METHYLTRANSFERASE) (L4SOASPARTYL PROTEIN CARBOXYL METHYLTRANSFERASE) 2869 8020 8.9 3.6OE-01 AF199485.1 NT Drosophila melanogaster sugar transporter 3 (sut3) mRNA, complete cds 3424 8566 13677 1.9 3.6OE-01 X76758.1 NT H.sapiens serotonin transporter gene, exons 9 and 10 3424 8566 13678 1.9 3.6OE-01 X76758.1 NT H.saplens serotonin transporter gene, exons 9 and 10 4192 9318 14402 0.9 3.6OE-01 BE251129.1 EST HUMAN 601107183F1 NII-LiviGC 16 Homo sapiens cDNA clone IMAGE:3343484 5' 4192 9318 14403 0.9 3.6OE-01 SE251129.1 EST-HUMAN 601107183F1 NILWQ_116 Homo saplens cDNA done IMAGE:3343484 5' 4635 9749 14844 "6. 9 3.6OE-01 AJ009609.1 NT Brassica napus mRNA for MAP4K alpha2 protein 4684 9796 14899 1.2 3.60E-01 AJ229237.1 NT Bacteria from anoyJc bulk soil 16S rRNA gene (strain XB45) 4941 10047 15119 2.0 3.6OE-01 AW339393.1 ESTHUMAN ha02g04xl NCI CGAP_Lu24 Horno sapiens cONA done IMAGE:2872566 3, 202 5396 10522 0.7 3.5OE-01 6678933 NT Mus musculus mannose receptor, Ctype 2 (Mrc2), mRNA 662 5818 10946 1.0 3.5OE-01 AL161581.2 NT Arabidopsis thaliana DNA chromosome 4, condg fragment No. 77 708 5862 10998 1.2 3.5012-01 7706136 NT Homo sapiens GAP-4ike protein (LOC51306), mRNA 708 5862 10999 1.2 3.5OE-01 7706136 NT Homo saplens GAP-tike protein (LOC51306), mIRNA 1622 6748 11916 1.1 3.5OE-01 U35776.11 NT Rattus norvegicus ADP- dbosylaflon factor-directed GTPase activating protein mRNA, complete cds 2563 7947 12859 -0.7 3.5012-01 AA223252.1 EST_HUMAN zrOBaOg.sl Stratagene NT2 neuronal precursor 937230 Homo saplens cIDNA clone IMAGE:650872 3' 2672 7759 0.9 3.5OE-01 U05897.11 NT Fibrobacter succinogenes S85 endoglucanase E (ceiE) and endoglucanase D (CeID) gene, complete cds 4165 9291 14371 1.9 3.5OE-01 AF071253.1 NT Danio rerio homeobox protein (hoxb5b) gene, complete ods 4379 9601 14588 1.3 3.5OE-01 BE146585.1 EST HUMAN RCS-HT0218-181099-01 1- g02 HT0218 Horno saplens cIDNA 4790 9901 14994 0.8 3.5012-01 N81203.1 EST HUMAN 788iEl fetal brain cDNA Homo sapiens cDNA done 78BiEl-K similar to R07879, Z40498 4849 9956 15045 3.8 3.5OE-01 M18349.1 NT Rat leukocyte common antigen (L- CA) gene, exons 1 through 5 691 5846 0.7 3.4OE-01 AJ242956.1 NT Homo saplens partial N-myc (exon 3), HPV45 L2, HPV45 0, HPV45 E6, HPV45 E7 and HPV45 Ell genes Isolated from 1C4 cervical carcinoma cell line 960 6105 11263 1.5 3.4012-01 Y09798.2 NT Pseudomonas fluorescens ooiR, colS genes, orf222 and partial InaA gene 13 6433 1159 0.6 3.4OE-01 Y00554.1 NT Azotobacter vinelandil nifA gene for NIM protein (posilive regulatory element) i- Page 19 of 196 Table 4

1321 WO 11615 0.6 3.4OE-01 AF057063.1 NT ErvAnia carotovora subsp. carotovora aspartate aminotransferase (aat) gene, partial cds; HexA (hexA), NADH dehydrogenase chain A (nuoA), and NADH dehydrogenase chain B (nuoB) genes, complete cds; and NADH dehydrogenase chain C (nuoC) gene, partial cds 2352 7454 12661 1.0 3.4OE-01 D90909.1 NT Synechocystis sp. PCC6803 complete genome, 11127,1311235-1430418 2642 7731 12932 1.5 3.4OE-01 AL161516.2 NT Arabidopsis thaliana DNA chromosome 4, contiq fragment No. 28 2679 7766 12967 1.1 3.4OE-01 AJ251835.1 NT Mus musculus Kcnq11, Urpc5, Mash2, Tapa-1, Tssc4 and Tssc6 genes, alternative transcripts 3124 8273 13378 5.4 3.4OE-01 U83905.1 NT Canis familiaris rod photoreceptor cGMP-gated channel alpha-subunit (CNGC1) mRNA, complete cds 3488 8629 13741 3.5 3.4OE-01 AF106835.1 NT Methylovorus sp. strain SSI putative GrpE (grpE), DnaK (dnaK), and putative DnaJ (dnaJ) genes, complete cds 3965 9097 1.2 3.4OE-01 AA584196.1 EST HUMAN nol 1b1O.sl NCI CGAP Phel Homo sapiens cDNA clone IMAGE:1 100347 3, 4394 9516 14606 0.8 3.4OE-01 AF166341.1 NT Homo sapiens Integr(n alpha 6 (ITGA6) gene. exons 12 through 23 4544 9663 14753 1.8 3.4OE-01 BE069912.1 EST HUMAN MR4-ST0403-230200-202- c01 BT0403 Homo saplens cDNA 4645 7766 12967 2.2 3.4OE-01 AJ251835.1 NT Mus musculus Kcnql, Ltripc5, Mash2, Tapa-1, Tssc4 and Tssc6 genes, alternative transcripts 4828 9936 15026 0.9 3.4OE-01 BE463761.1 EST HUMAN hy117d09.xl NCI- CGAF_GC6 Homo sapiens cDNA clone IMAGE:3197585 3'simiiar to contains Ll.t3 L1 repetitive element; 4870 9977 3.6 3.4OE-01 A1240973.1 EST-HUMAN qi95c05.xl NCI_PGAP_Kjd3 Homo sapiens cDNA done IMAGE:1867208 3'similar to contains Alu repetitive element; 4970 10073 15146 1.2 3.4OE-01 X16544.1 NT Sea urchin hsp70 gene 11 for heat shock protein 70 14 5222 10323 113 3.3OE-01 X07990.1 NT Rhizoblurn leguminoserum syrn plasmid pRL5J( nodX gene 5222 10323 2.7 3.3OE-01 X07990.1 NT Rhizobium leguminosarum sym plasmid pRLSJI nodX gene 440 5606 10740 1.2 3.3OE-01 AL161545.2 NT Arabidopsis thaliana DNA chromosome 4, condg fragment No. 45 617 5176 10898 1.4 3.3OE-01 7662485 NT Horno, sapiens K1AA11 100 protein (K1AA1100), mRNA 1182 6315 11472 1.0 3.3OE-01 Q12446 SWISSPROT PROLINE-RICH PROTEIN LAS17 1588 6714 11884 1.1 3.3OE-01 6753685 NT Mus musculus disintegri 5 (D9n5), mIRNA 1704 6827 1.1 3.3OE-01 AA332734.1 EST HUMAN EST36722 Embn, 8 week 1 Homc sapiens cDNA 9 end 2355 7457 1,7 3.3OE-01 4507834 NT Homo saplens uridine monophosphate synthetase (orotate phosphoribosyl transferase and orobdine-C-decarboMase) (UMPS) mRNA 2752 7836 13037 1.1 3.3OE-01 AJ132478.1 NT Chlamyoomonas reinhardti STFI gene, partial 2760 7844 13046 3.1 3.3OE-01 8923039 NT Homo saplens hypothetical protein FLJ20036 (FLJ20036), mRNA 2919 8070 13180 2.0 3.3OE-01 AJ251805.1 NT' Bactedophage phi-YeO3-12 complete genome 2982 8134 1.1 3.3OE-01 002743 SWISSPROT INTERLEUKIN-12 ALPHA CHAIN. PRECURSOR (IL-1 2A) (CYTOTOXIC LYMPHOCYTE MATURATION FACTOR 35 K1) SUBUNIT) (CLMF P35) 3016 8168 13269 1.0 3.3OE-01 AJ007932.2 NT Streptomyces argillaceus mithramycin blosynthefic genes 3450 8592 13705 1.1 3.3OE-01 AB012922.1 NT Homo saplens MTAI-LI gene, complete cds 3738 8875 13965 2.2 3.3OE-01 084645 SWISSPROT EXODEOXYRISONILICILEASE V BETA CHAIN 3884 9020 14114 1.6 3.3OE-01 AL161498.2 NT Arabidopsis thaliana DNA chromosome 4, config fragment No. 10 3920 9054 14141 1,9 3.3OE-01 AF200446.1 NT Hypoxylon fragiforme chifin synthase gene, partial cds Page 20 of 196 Table 4

4271 9396 2,7 3.3012-01 D311662.1 NT Rattus norvegicus DNA for regucaldn, partial ods 4589 9703 1,5 3.3OE-01 A1539114.1 EST HUMAN tp78b12.xl NCI_MAP_W Homo sapiens cDNA done IMAGE.2205407 Ysimilar to gb:X57522 ANTIGEN PEPTIDE TRANSPORTER 1 (HUMAN); 5133 10228 15303 1.0 3.3OE-01 W30992.1 EST HUMAN zb85b03xl Soare!- "nescent-fibrobtasts-NbHSF Homo sapiens cDNA clone IMAGE:310349 6 449 5615 0.7 3.2OE-01 AF018261.1 NT Rattus norvegicus EH domain bindinE protein Epsin mRNA, complete cds 701 5856 0.7 3.2OE-01 AL161561.2 NT Arabidopsis thallana DNA chromosome 4, config fragment No. 61 1146 61281 11434 6.5 3.2OE-01 AF047013.1 NT Fusaflurn poae virus 1 RNA2 putative RNA dependent RNA polymerase gene, complete cds 81 1261 6390 11551 1.0 3.2OE-01 Z50202.1 NT P.vulgaris arc5A gene 6 90 1368 6496 11662 2.3 3.2OE-01 Q48624 SWISSPROT LACTOSE PERMEASE (LACTOSE- PROTON SYMPORT) (LACTOSE TRANSPORT PROTEIN) 1737 6660 12038 1,2 3.2OE-01 Z36041.1 NT S.cerevislac chromosome 11 reading frame ORF YBR172c 1744 6867 12045 2.0 3.2OE-01 AW957194.1 EST-HUMAN EST369264 MAGE resequences, MAGID Homo sapiens c1DNA 1744 6867 12046 2.0 3.2OE-01 AW957194.1 ESTHUMAN EST369264 MAGE re6equences, MAGID Horno sapiens cDNA 1800 6920 12106 1.2 3.2OE-01 ALI 11655.1 NT Botryds dnerea strain T4 cDNA library under conditions of nitrogen deprivation 2494 7590 1.1 3.2OE-01 7710079 NT Mus musculus Pbynotted 1, homeobox (Pknoxl), mRNA 2677 7764 12965 0.6 3.2OE-01 AF060568.1 NT Horno sapiens promyelocytic: leukernia zinc finger protein (PLZF) gene, complete cds 3556 8695 1,0 3.2OE-01 D10872.1 NT Hurnam h NAT allele 3-2 gene for arylamine Wacetyltransferase 3868 9004 1.0 3.2OE-01 AL161546.2 NT Arabidopsis thallana DNA chromosome 4, contig fragment No. 46 4295 9419 14509 1 3.2OE-01 M18818.1 NT Rabbit beta-like globin gene cluster encoding the epsilon, gamma, delta (pseudogene) and 1.4 beta globin polypeptldes, complete cds 4375 9497 14584 0.8 3.2OE-01 AF111167.2 NT Horno saplens jun dimerization protein gene, partial ods; 005 gene, complete cds; and unknown gene 4397 9519 14609 1.3 3.2OE-01 010268 SWISSPROT HYPOTHETICAL 81.7 KO PROTEIN C13G7.04C IN CHROMOSOME 1 PRECURSOR 4907 10014 1.2 3.2OE-01 M32352.1 NT Mouse renin (Ren-l-d) gene, complete ods 2636 7725 12929 1.4 3.1OE-01 R180511.1 EST-HUMAN ye90h06xl Soares fetal liver spleen WLS Homo sapiens cDNA clone IMAGE:125051 5' similar to gb:M64241 QM PROTEIN (HUMAN); 2665 7877 12951 1.3 3.1OE-01 7661971 NT Homo sapiens KIAA0174 gene product (K1AA0174), mRNA 2665 7877 12952 1.3 3.1OE-01 7661971 NT Homo sapiens KIAA0174 gene product (K1AA0174), mIRNA 2827 7978 1.0 3.1OE-01 AW629036.1 EST-HUMAN W46h08.xl Soares NFL T G13Q_S1 Horno sapiens cDNA clone IMAGE:2975391 X 3136 8285 2.8 3.1OE-01 AB029069.1 NT Mus musculus gene for Ser/Thr kinase KKIAMRE, exon 6 3832 8969 14068 1.2 3.1OE-01 AJ251586.1 NT Daucus caro-ta mRNA for transcription factor E2F (E2F gene) 5073 10171 15249 1.0 3.1OE-01 AA576308.1 EST-HUMAN nm61h0S.si NCI CGAP Br3 Horno sapiens eDNA done IMAGE:1072761 3' 66 7857 10398 0.5 3.OOE-01 6755083 NT Mus musculus protein kinase Q epsilon (Pkce), mRNA 254 5442 10569 3.8 3.OOE-01 AJ271735.1 NT Homo saplens Xq pseudoautosomal region; segment 112 1204 6336 11492 0.6 3.OOE-01 AW300400.1 EST HUMAN xs63f08xl NCUGA12 Kidll 1 Homo sapiens cDNA done IMAGE:2774343 3' 1491 6618 11788 2.3 3.OOE-01 AJ006755.1 NT Balaenoptera physalus. gene encoding abial natduredc pepjde 30 11799 0.9 3.OOE-01 69.1 EST HUMAN tc42c05.xl Soares-totaLfetus-Nb2HF89w Homo sapiens cDNA clone IMAGE:2067272 X Page 21 of 196 Table 4

2089 7200 12405 0.9 3.OOE-01 AF237778.1 NT Rattus norvegicus Ca2+ Icalmodulin-dependent protein kinase 11, alpha subunit mRNA, 3' untranslated region 3175 8324 13937 1.0 3.OOE-01 AB030481.1 NT Corynebacterium sp. ALY-1 lyPG gene for polyguluronate Iyase, complete cds 3709 8847 1.1 3.OOE-01 AF229122.1 NT Homo sapiens acetylcholinesterasecollagen-like tail subunit (COLQ) gene, exons 11 A and 12; and complete cds, alternatively spliced 3789 8926 14020 1.3 3.OOE-01 AW817785.1 EST_HUMAN PMI-ST0262-261199-001- 901 ST0262 Horno, saplens cDNA 4104 9230 1.7 3.0012-01 L42123.1 NT Mus musculus fibroblast growth factor receptor 3 (FGFIR3) gene, intron 9 4412 9532 14621 1.9 3.OOE-01 AJ006755.1 NT Balaenoptera physalus gene encoding atrial natriurefic pepfide 1038 6178 11331 0.5 2.9OE-01 AA090216.1 EST HUMAN chp0182.seq.F Human fetal heart, Lambda ZAP Express Homo sapiens cDNA S' 1100 6238 11390 0.9 2.9OE-01 BE066156.1 EST-HUMAN CMO-BT0320-261199-103- a06 BT0320 Homo sapiens cDNA 1978 7093 12294 0.6 2.9OE-01 AE000736.1 NT s section 68 of 109 of the complete genome 2201 7310 12521 1.0 2.9OE-01 AF222718.1 NT Chrysodidymus synuroideus mitochonddon, complete genome 3147 8296 13405 1.0 2.9OE-01 AF07811 1.1 NT Xenopus laevis transcription factor E2F mIRNA, complete cds 3213 8361 13471 2.3 2.9OE-01 AW754239.1 EST-HUMAN PM1-CT0326-171299001412 CT0326 Homo sapiens cDNA 3213 8361 13472 2.3 2.9OE-01 AW754239.1 EST-HUMAN PM1-CT0326-171299-001- f12 CT0326 Homo sapiens cDNA 3821 8958 14054 1.3 2.9012-01 A1610836.1 EST HUMAN tp21al 1.xl NCI_PGAP- Gas4 Homo sapiens cDNA clone IMAGE:2188412 Ysimilar to gb:D15050 NIL-2-A ZINC FINGER PROTEIN (HUMAN);contains element 1.1 repetitive element; 3994 9126 0.8 2.9OE-01 AW002902.1 EST HUMAN wr02110.xl NCI CGAP GC6 Horno sapiens cDNA done IMAGE:2480395 3' 4384 9506 14591 1.0 2.9OE-01 AA284468.1 EST-HUMAN zs57d12.rl NCLWAP-GC131 Homo sapiens cIDNA clone IMAGE:701591 5'similar to contains Alu repetitive element; 4388 9510 14596 0.8 2.9OE-01 AF134119.1 NT Mus musculus SK1)l (SW1) gene, complete cds 4388 9510 14597 0.8 2.9OE-01 AF134119.1 NT Mus musculus SK1)l (SW1) gene, complete cds 4729 9a41 14933 0.9 2.9012-01 AB019029.1 NT Mus musculus gene, 6omplete cds, similar to EXLM1 4903 10010 0.9 2.9OE-01 AF1 19676.1 NT Mus musculus small GTP-binding protein RAB25 (Rab25) gene, complete cds 556 5719 0.6 2.8OE-01- U67136.1 NT Rattus norvegicus A-kinase anchoring protein AKAIP1 W mRNA, complete cds cds 1067 6205 11360 0.8 2.8OE-01 AF168050.1 NT Guira guira oocyte maturation factor Mos (c-mos) gene, partial 1197 6329 11484 1.1 2.8OE-01 AF134404.1 NT Homo saplens delta-6 fatty add desaturase ( B5RP) mRNA, complete cds 1256 6385 11545 1.1 2.8OE-01 BE313442.1 EST HUMAN 601148733F1 NIM MGQ_119 Horno sapiens cDNA done IMAGE:3163688 5' 1256 6385 11546 1.1 2.8OE-01 BE313442.1 EST HUMAN 601148733F1 N1H MGQ_19 Homo sapiens cDNA done IMAGE:3163688 5, 1269 6398 11557 1.0 2.8OE-01 D86550.1 NT Human mRNA for sednelthreonine protein kinase, complete cds 1696 6820 12002 0.6 2.8OE-01 AW860020.1 EST HUMAN QV1-CT0364-120200-065- boS CTO364 Homo sapiens cDNA 1966 7082 12282 0.6 2.8012-01 AL047620.1 EST HUMAN DI(FZp58612321 r11 586 (syn nym: hutel) Homo sapiens cDNA done DKFZp58612321 2084 7196 12401 0.5 2.8OE-01 AW511195.1 EST HUMAN hd44b03.xl Soares NFGBC S1 Homo, sapiens cDNA clone IMAGE:2912333 3' 2134 7244 12451 0,8 2.8012-01 AF100152.1 NT Drosophila melanogaster connector enhancer of KSR protein CNK mRNA, complete cds 2243 7349 0.9 2.8OE-01 AW177111.1 EST HUMW CMI.CTO127-160899-005-d01 CTO127 Homo sapiens cDNA 2423 7522 12729 1.1 2.8012-01 AE000494.1 NT Escherichia coll K-12 MG1655 section 384 of 400 of the comelete genorne 2423 7522 12730 1.1 2.8OE-01 AE000494.1 NT Escherichla coll K-12 MG1655 section 384 of 400 of the complete genome 2500 7597 0.9 2.8OE-01 AL1 61565.2 NT Arabidopsis thaliana DNA chromosome 4, config fragment No. 65 12920 1.4 2.8OE-01 AB020975.1 NT Arabidopsis thallana mIRNA for lipoyltransferase, complete cds Page 22 of 196 Table 4

2940 8091 13199 1.5 2.8OE-01 AF179480.1 NT Toxoplasma ondll 9OkDa heatshock protein (HSP910) MRNA, partial cds 2941 8092 13200 2.5 2.8OE-01Z14037.1 NT B.taurus microsatellite (ETH121) 2941 8092 13349 2.5 2.8OE-01 Z14037.1 NT A.chrysaetos mitochondnal cytochrome b gene 3095 8246 13589 10.7 2.8OE-01 Z73462.11 NT Pyrococcus hodkoshil OT3 genomic DNA, 777001-994000 nt. position (417) 3332 8476 1.1 2.8OE-01 AP000004.1 NT 4, fragment No. 89 3704 8842 0,9 2.8OE-01 AL161593.2 NT Arabidopsis thallana DNA chromosome config 66 of 70) of the complete genome 3915 9049 14136 1,8 2.8OE-01 AE001 180.1 NT Borrelia burgdorfed (section Homo sapiens cDNA clone IMAGE:1640226 Ysimilar to 4103 9229 2.2 2.8OE-01 A1090868.1 EST HUMAN ov44g10.xl Soares-testis-NHT contains Alu repetitive element;contains element MER22 repetitive element; X contgA; putative Mageag gene, Caltractin, NAUtt') steroid Mus musculus chromosome 4352 9474 14566 1.0 2.8OE-01 AL021127.2 NT dehydrogenase and Zinc finger protein 185 4357 9479 14570 2,2 2.8OE-01 P13615 SWISSPROT RNA POLYMERASE BETA SUBUNIT (LARGE STRUCTURAL PROTEIN) (L PROTEIN) 2 (p53BF2), partial cDNA 4421 9541 14633 1.7 2.8012-01 U58881.1 NT Mus musculus P53 binding protein homolog complete cds 4525 9644 14734 0.8 2.8OE-01 AF032870.1 NT -Drosophila elan2gaster, Sharpel/L)RnoGEF2mRNA, factor AREB6, complete eds 4673 9785 14884 1,0 2.8OE-01 D15050.11 NT 1 4673 9785 14885 1.0 2.8OE-01 D15050.1 NT Human mRNA for transcription factor AREB6, complete cds 4722 9834 14926 2.8 2.8OE-01 AF030154.1 NT Bovine adenovirus 3 complete genome constant heavy chain, allele Igh-1 4771 10303 3,2 2.8OE-01 Y10606.1 NT M.Musculus IgG2c gene for Immunoglobulin Homo saplens cDNA done IMAGE:1 876628 3'similar to 4787 9898 14991 1.7 2.8OE-01 A1272669.1 EST HUMAN q159cl 1.xl Soares_NhHIVII3u-S1 5173 10267 15337 0.9 2.8OE-01 S69963.1 NT contains Alu repetitive element; oontalns element LTR5 repetitive element; mnp2=manganese peroyJdase Isozyme 2 {heat-shock elements, metal response elements) [Phanerochaete chrysosporlum, Genomic, 3297 ntl Isozyme 2 (heat-shock elements, metal response elements} 5173 10267 15338 0.9 2.8OE-01 S69963.1 NT mnp2=manganese peroyJdase 468 5633 10762 0,8 2.7OE-01 Y17324.1 NT [Phaneroch ete chrysosporium, Genomic, 32137 nt) Rattus norvegicus CDK104 mRNA Soares_total-fetus_Nb2HFO_gw Homo sapiens cDNA clone IMAGE:788827 3' zx39b1O.sl _'__597 5755 10873 1.1 2.7OE-01 AA450061.1 EST HUMAN similar to contains AW repetitive element; element 1 lpl 00 gene for transposase, complete cds 1240 6369 11528 0.5 2.7OE-01 ABOO4906.1 NT lpomoea purpurea transposable 1604 673-1 12003 0.6.7012-01 X79815.1 NT G.1amblia SR2 gene 1698 6822 1.1 2.7OE-01 W58067.1 EST_HUMAN zd22h10xl Soares_fetal- hearLNbHH19W Homo saplens cDNA clone IMAGE:341443 5' GAG POLYPROTEIN [CONTAINS: INNER COAT PROTEIN P12; CORE PROTEIN P15; 1738 6861 12039 1.3 2.7OE-01 P03341 SWISSPROT CORE SHELL PROTEIN P30; NUCLEOPROTEIN P10] 2088 7934 12626 0.9 2.7OE-01 AF047575.1 NT Rattus norvegicus vesicular monoamine transporter type 2, promoter region and exon 1 2316 7419 3.2 2.7OE-01 Y1 3868.1 NT Feline Immunod-efidency virus env gene, Isolate ITT0088PlU (M88), partial Homo sapiens cDNA done IMAGE:2046836 3'sImilar to ta43c11.x2 NCI_PGAP_Lu25 2406 7505 12712 1.3 2.7OE-01 A1310858.1 EST HUMAN contains element L1 repetitive element; PRECURSOR (TWX) (HEXABRACHION-LIKE) 2629 7719 12919 1.5 2.7OE-01 P22105 SWISSPROT TENASCIN-X CUNA done IMAGE:2462828 3' 3929 9063 14150. 1.9 2.7OE-01 A1928015.1 EST HUMAN wo92el 1 xl NCI CGAP Kidl 1 Morno saplens critical region, telomeric end 3943 9 14158 -7-3 2.7012-01 Homo sapiens DiGeorge syndrome Page 23 of 196 Table 4

4286 9411 14498 5.1 2.7OE-01 6680855 NT Mus musculus corticosteroid binding globulin (Cbg), mRNA 4796 9907 15000 0.9 2.7OE-01 L27516.1 NT Triticum aestivum (Wcs66) gene, complete cds 4973 10076 3.5 2.7OE-01 AW856131.1 EST HUMAN RC1-CT0286-230200-016-e03 CT0286 Homo sapiens cDNA 5190 10281 15349 0.8 2.7OE-01 BE182123.1 EST HUMAN PM3-HT0642-290300-001b05 HT0642 Homo saplens cDNA 462 7889 10756 0.5 2.6012-01 P78411 SWISSPROT IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-2 472 5638 1.4 2.6OE-01 D16459.1 NT Bos taurus mRNA for mb-1, complete cds 1355 6483 11649 1.0 2.6OE-01 4557640 NT Homo saplens histone deacetylase 2 (HDAC2), mRNA 1355 6483 11650 1.0 2.6OE-01 4557640 NT Homo saplens histone deacetylase 2 (HDAC2), mRNA 1418 6546 11720 1.0 2.6OE-01 A13013290.1 NT Glydne max pseudgene for Bd 30K 1854 6972 12156 3.1 2.6OE-01 AL161472.2 NT Arabidopsis thaliana DNA chromosome 4, config fragment No. 2 1854 6972 12157 2.6OE-01 AL161472.2 NT Arabidopsis thallana DNA chromosome 4, config fragment No. 2 2046 7159.3.6 2.6011-01 AW733152.1 EST HUMAN bbO4d10.xl NIH - MGC - 14 Homo saplens cDNA clone IMAGE:2958451 Ysimilar to gb:M36072 60S RIBOSOMAL PROTEIN L7A (HUMAN); gb:M14689-cdsl Mouse surfeit locus surfeit 3 protein gene (MOUSE); 2106 7217 12427 1.2 2.6OE-01 M118".1 NT Human prealbumin gene, complete eds 2424 7523 1.0 2.6OE-01 Y12996.1 NT B.madtimus rbcL gene 2499 7696 3.5 2.6OE-01 BE272440.1 EST-HUMAN 601126016F1 NIH MGC 9 Homo sapiens cDNA clone IMAGE:2990043 5' 3053 8204 1.0 2.6OE-01 AW974531.1 EST-HUMAN EST386635 MAGE resequences, MAGM. Homo sapiens cDNA 3485 8626 0.9 2.6OE-01 BE217816.1 EST HUMAN hv30c02.xl NCI-CGAP_Lu24 Homo saplens cDNA done IMAGE:3174914 3' similar to contains 1.113 1.1 repetitive element; 3532 8673 13777 1.1 2.6OE-01 M22342.1 NT Bactedphag T2 DNA-(adenineN6)methyltransferase (dam) gene, complete cds 3591 8730 13827 1.7 2.6012-01 AF229118.1 NT Homo sapiens acetylcholinesterase collagen-like tail subunit (COLCI) gene, exons 1 A, 2, 3, 4.

and 5 3651 8790 13883 0.9 2.6OE-01 A13017446.1 NT Rattus norvegicus mRNA for organic anion transporter 3, complete cds 4010 9141 14223 1.0 2.6OE-01 AW959510.1 EST HUMAN EST371580 MAGE resequences, MAGF Homo sapiens cDNA 4062 9189 14274 13.1 2.6OE-01 BE080598.1 EST HUMAN QV1-BT0630-040400-132e03 BT0630 Homo sapiens cDNA 4259 9384 14467 1.0 2.6OE-01 AF175293.1 NT Enterococcus faedum strain N97- 330 vanD glycopeptIde resistance gene cluster, complete ods; and unknown gene 4393 9515 14604 0.8 2.6OE-Oi AB0211180.1 NT Gallus gallus mRNA for skeletal myosin heavy chain, complete cds 4393 9515 14605 0.8 2.6OE-01 A13021180.1 NT Gallus gallus mRNA for skeletal myosin heavy ain, complete cds 4448 9568 14666 1.2 2.6OE-01 AA457617.1 EST HUMAN aa89d07xl Stratagene fetal retina 9j7202 Homo sapiens cDNA done IMAGE:838477 5' 4548 9667 14756 1.6 2.6OE-01 U01 103.1 NT Arabidopsis thallana PSI type Ill chlorophyll alb-binding protein (Lhca31) mRNA, complete ods 4616 9730 14824 1.3 2.6OE-01 AF142703.1 NT Ophrestia radicosa maturase- like protein (matK) gene, complete cds; chloroplast gene for chloroplast product 4672 9784 14883 2.2 2.6OE-01 AW027920.1 EST-HUMAN ws62hl 1.xl INICI--- PGAP - 13m23 Homo sapiens cDNA done IMAGE:2501829 3' similar to SW:1VIE13-MOUSE P97368 HOMEOBOX PROTEIN MEIS3; 4896 10003 15086 3.6 2.6OE-01 H04858.1 EST HUMAN yj51c05.rl Soares placenta Nb2HP Homo sapiens cDNA clone IMAGE:1 52288 5' 5051 10151 15228 0.9 2.6OE-01 P08503 SWISSPROT ACYL-COA DEHYDROGENASE, MEDIUM-CHAIN SPECIFIC, MITOCHONDRIAL PRECURSOR(MCAD) Page 24 of 196 Table 4

241 5431 10557 0.7 2.5OE-01 4502296 NT Horno sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit (ATP5D), nuclear gene encoding mitochondrial protein. mRNA 242 5431 10557 0,6 2.5OE-01 4502296 NT Horno saplens ATP synthase, H+ transporting, mitochonddat F1 complex, delta subunit (ATP5D), nuclear gene encoding mitochonddal protein, mRNA 255 5443 1,1 Z-50E-01 M26501.1 NT Starfish (P.ochraceus) cytoplasmic actin gene, complete cds 815 5965 11121 1.3 2.5OE-01 U09964.1 NT Mus musculus ICRtSvAss glyceraldehyde 3-phosphate dehydrogenase (Gapd-S) gene, complete cds 10M 6184 1.9 2.5OE-01 AE002156.1 NT Ureaplasma urealyticum section 57 of 59 of the complete genome 1105 6243 11396 3.2 2.5012-01 T89837.1 EST HUMAN yell g07.rl Stratagene lung (#937210) Horno sapiens cONA done IMAGE: 117468 5' 1503 6629 11798 0.9 2.5OE-01 AL1 15624.1 NT Botryds cinerea shin T4 cDNA library under conditions of nitrogen deprivation 1697 6821 2.0 2.5OE-01 4885406 NT Horno sapiens hyperpolarization activated cyclic nudeodde-gated potassium channel 4 (HCN4) mRNA 2357 7459 3.0 2.5OE-01 AE000675.1 NT Aquifex aeollcus section 7 of 109 of the. complete genome 2446 7545 1.4 2,5012-01 AA251987.1 EST-HUMAN zsl 1a12.rl NCI CGAP GCBI Horno saplens ciDNA clone IMAGE:684862 S' 2597 7688 12891 1.0 2.5OE-01 X95310.1 NT B.taurus mRNA for D-aspartate oyldase 3366 8509 2.9 2.5OE-01 AW973471.1 EST-HUMAN EST385464 MAGE resequentes, MAGM Homo saplens cDNA 3490 8631 13743 0,9 2.5OE-01 AF233875.1 NT Danio reflo Reptide YY precursor gene, complete ods 3502 8644 13752 7.9 2.5OE-01 AL161517.2 NT Arabidopsis thallana DNA chromosome 4, condg fragment No. 29 3774 8911 14000 1,2 2.5OE-01 A1741483.1 EST_HUMAN w911 1c07.xl Soares- NSF_FQ_9VV_01.PkP_SI Horno saplens cDNA clone iMAGE:2364780 3' 3774 8911 14001 1,2 2.5OE-01 A1741483.1 EST-HUMAN wgI 1 c07.xl Soares_NSFF"V_01_PA_P_S 1 Homo sapiens cIDNA clone IMAGE:2364780 3' 3895 9030 14123 7.4 2.5OE-01 Q04912 SWISSPROT MACROPHAGE-STIMULATING PROTEIN RECEPTOR PRECURSOR (MSP RECEPTOR) (P185-RON) (CM136) (C1)136 ANTIGEN) 3895 9030 14124 7.4 2.5OE-01 Q04912 SWISSPROT MACROPHAGE-STIMULATING PROTEIN RECEPTOR PRECURSOR (MSP RECEPTOR) (P1185-RON) (COW136) (C1)136 ANTIGEN) 3977 9109 0.8 2.5OE-01 P32323 SWISSPROT A-AGGLUTININ ATTACHMENT SUBUNIT PRECURSOR 4222 9346 1.2 2.5OE-01 Q03314 SWISSPROT RHIB PROTEIN 4514 9633 14725 1,0 2.5OE-01 AF242431.1 NT Mus muscuJus neuronal apoptosis inhibitory protein 6 (Naip6) gene, complete cds; and Naip3 gene, exons 2-9 and 11-16 4643 9757 1.1 2.5OE-01 Q27225 SWISSPROT MOLT-INHIBITING HORMONE PRECURSOR (MIH) 4649 9761 14856 3.8 2.5OE-01 AF007768.1 NT Chodstoneura furniferana diapause associated protein 2 (DAP2) mRNA, complete ods 4698 9810 3.2 2.5OE-01 AJ230113.1 NT Mus musculus anne)dn V gene, intron 4 segment containing Y1-TIR and gag portion of MuERV-L (murine endogenous retrovirus) element 4750 9861 14953 0.9 2.5OE-01 AB01 1070.1 NT Mus musculus gene for uncoupling protein 3, V-fianking region and pardal VUTR 5169 10263 15334 0.9 2.5OE-01 AW663183.1 EST HUMAN hh75f09.yl NCI CGAP - GU1 Honno, sapiens cIDNA done)MAGE:2968649 5'similar to contains TAR1h TARi repeutive element; 5169 10263 15335 0.9 2.5OE-01 AW663183.1 EST-HUMAN hh75f09.yll NCI-CGAP- GUI Horno sapiens cDNA clone WA E:29 8649 5'similar to contains TAR1A2 TARI repetitive element; 541 5704 10824 0.5 2.4OE-01 AA936316.1 EST-HUMAN on70d04.sl Soares_NFL. G8C S1 Homo sapiens cDNA clone IMAGE:1 562023 X 1282 6412 11573 5.9 2.4OE-01 A.1289880.1 NT Homo saplens KIAA0851 gene (partial), XT3 gene and LZTFL1 gene lj-) Page 25 of 196 Table 4

1282 6412 11574 5.9 2.4OE-01 AJ289880.1 NT Homo sapiens KIAA0851 gene (partial), XT3 gene and LZTFL1 gene 1362 6490 11655 1.0 2.4OE-01 Y17293.1 NT Homo sapiens FLI-1 gene, partial 1808 6927 8.7 2.4012-01 AF267753.1 NT Mesembryanthemum crystallinum putative potassium channel protein Mktlp mRNA, complete ods 1858 6976 12161 0.5 2.4OE-01 AF251708.1 NT Zaocys dhumnades fructose-1,6- bisphosphatase mRNA, complete cds 2091 7202 12407 0.9 2.4OE-01 AF111168.2 NT Homo sapiens sedne paimitoyl transferas.e, subunit 11 gene, complete cds; and unknown genes 2122 7232 1.2 2.4OE-01 P45384 SWISSPROT IMMUNOGLOBULIN All PROT-EASE PRECURSOR (IGA1 PROTEASE) 2215 7323 12537 0.7 2.4OE-01 AE000680.1 NT Aquifex aeolicus section 12 of 109 of the complete genome 2491 7588 12792 0.6 2.4OE-01 Z36534.11 NT D.discoideum (Ax3-K) ponA gene 2734 7818 13023 0.8 2.4OE-01 X71783.1 NT S.pombe svA6 gene 2756 7840 13042 2.4 2.4OE-01 AF030154.1 NT Bovine adenovirus 3 complete genome 3093 8244 2.8 2.4OE-01 U72726.1 NT Oryza longistaminata receptor kinase- like protein, family member D, and retrofit (gag/pol) genes, complete cds 3109 8259 13363 1.9 2.4OE-01 X74209.1 NT H.sapiens AGT gene, Psti fragment of Intron 4 3871 9007 14106 2.4 2.40E-01 AJ009961.1 NT Fugu rubripes PRGFRI gene, exons 1-20 4594 9708 14800 78.8 2.4OE-01 Y13183.1 NT Herpesus saimid C-488 DNA for ORF.12 to 25 4704 9816 14913 1.3 2.40 E-01 A1123160.1 EST HUMAN cia86c07.sl Soaresfetal-heart-NbHH19W Homo sapiens cDNA clone IMAGE:1693644 X 4817 9926 15018 0.9 2.4OE-01 BE160080.1 EST HUMAN OV1-HT0412-020400-136- blO HT0412 Homo sapiens cDNA 4981 10084 15154 50.2 2.4OE-01 D00944.1 NT Hepatitis C virus genomic RNA for polyprotein, complete cds 5101 10197 15277 1.0 2.4OE-01 A1302019.1 EST HUMAN qo23101.xl NCI CGAP Lu5 Homo sapiens cDNA clone IMAGE:1909369 3' 5188 10279 15347 1.4 2.4OE-01 7657600 NT Mus musculus small optic lobes homolog (Drosophila) (Solh), mRNA 383 5552 10685 0.9 2.3OE-01 S75898.1 NT aromatase [Poephila guttata=zebra finches, ovary, mRNA, 3188 nt) 621 5780 1.5 2.3OE-01 U39713.1 NT Mycoplasma genitalium section 35 of 51 of the complete genome 651 5809 10935 6.8 2.3OE-01 U67596.1 NT Methanococcus jannaschil section 138 of 150 of the complete genome 792 5943 11094 4.4 2.3OE-01 AE001708.1 NT Thermotoga maddma section 20 of 136 of the complete genome 851 6000 11160 1.6 2.3OE-01 AE001708.1 NT Thermotoga maritima section 20 of 136 of the complete genome 918 6064 11219 1.1 2.3OE-01 BE311893.1 EST-HUMAN 601142073F1 N1H MGC 14 Homo saplens cDNA done IMAGE:3505818 5' 1494 6620 11790 0.5 2.3OE-01 6677980 NT Mus musculus vacuolar protein sorting 4b (yeast) (Vps4b). mRNA 1546 6673 0.9 2.3OE-01 U22837.2 NT Yersinia pestis HmsH (hmsH), HmsF (hmsF), HmsR (hmsR), and HmsS (hmsS) genes, complete cds 1586 6712 11883 1.4 2.3OE-01 AJ245480.1 NT Brassica napus sig gene for Slocus glycoprotein, cultivar T2 1614 6740.11910 1.0 2.3OE-01 Y10887.2 NT Mus musculus cdh5 gene, exon 1, partial 1999 7114 1.3 2.3OE-01 AJ235353.1 NT Homo sapiens partial Intron 3 of the wild type AF-41FEL gene 2396 7496 12701 0.6 2.3OE-01 BE297718.1 EST-HUMAN 601175562F1 N1H MGC 17 Homo sapiens ONA clone IMAGE:3531015 5' 2615 7705 12904 1.0 2.3OE-01 M11319.1 NT Human erythropolefin gene, complete cds 2757 7841 13043 0.5 2.3OE-01 AF004708.1 NT Medicago sativa aquaporin-like transmembrane channel protein (pAFI 8-1) mRNA, complete cds 2757 7841 13044 0.5 2,3OE-01 AF004708.1 NT Medicago sadva aLquaporin-like transmembrane channel protein (pAFI 8-1) mRNA, complete cds Page 26 of 196 Table 4

2794 6493 11659 0,9 2.3OE-01 A13015033.1 NT MarInflabilla agarovorans gyrB gene for DNA gyrase subunit B, partial cds, strain:IFO 14957 2934 8085 13193 1.3 2.3OE-01 AA601379.11 EST-HUMAN nol6d06.sl NCI_qGAF_Phel Horno sapiens cDNA done IMAGE:1 100843 Ysimilar to contains Alu repeddve elementcontalns element THR repetitive element; 2950 8101 13207 0.9 2.3OE-01 ABOO5200.1 NT Mus musculus DNA for DNA dependent protein kinase catalytic subunit, exon 69 3045 8196 5,7 2.3OE-01 R21732.1 EST-HUMAN yh21b07.sl Soares placenta Nb21- 1P Homo saplens cDNA done IMAGE: 130357 3' 3324 8468 13583 1.1 2.3OE-01 H69836.1 EST HUMAN yr97h1O.rl Soares fetal liver spleen 1NFI-S Homo sapiens cDNA clone IMAGE:213283 5' 3766 8904 13993 1,1 2.3OE-01 S82821.1 NT GSTA5=9lutathione S-transferase Yc2 subunit (V region, Intron 1} [rats, Morris hepatoma cell fine, Genomic, 2212 nt, segment 1 of 31 3856 8992 3.7 2.3OE-01 7662133 NT Homo saplens KIAA0450 gene product (K1AA0450), mRNA 4253 9378 14458 0.9 2.3OE-01 R82252.1 EST HUMAN yj17101.rl Soares placenta Nb21-112 Homo sapiens cDNA done IMAGE:149017 5' 4300 9424 3.4 2.3OE-01 L78789.1 NT Mus musculus renin (Ren-1 c) gene, promoter region 4349 9471 14563 1.0 2.30E-01 D90899.1 NT Synechocysfis sp. PCC6803 complete genome, 1127, 1-133859 4386 9508 14593 2.1 2.3OE-01 AF092535.1 NT Homo saplens ffiltogen- acdvated protein kinase p38delta (PRKM13) mRNA, complete cds 4454 9574 14672 5.1 2.3OE-01 5031984 NT Homo saiens nudear transport factor 2 (placentat protein 15) (PP15) mRNA 4582 9698 14792 22.6 2.3012-01 ABOO1995.1 NT Schizosaccharomyces pombe gene for Tell p, complete cds 4956 9894 14987 0.8 2.3OE-01 J03280.1 NT Human ph nylethanolamine Wmethyltransferase gene, complete cds 5020 10121 15193 3.7 2.3OE-01 AE003995.1 NT Xylella fastidlosa, section 141 of 229 of the complete genome 5146 10241 15315 27.0 2.3OE-01 AE000240.1 NT Eschedchia coil K-12 MG1655 secdon 130 of 400 of the complete genome 84 5290 10417 1.0 2.2OE-01 A1052190.1 EST HUMAN oz14al 0.xl Soares-fetalliveLspleer!_1 WLS_S1 Homo saplens cDNA done IMAGE:1675290 Ysimilar to TR:Q13040 Q13040 ATP-BINDING CASSETTE PROTEIN; 1545 6672 11843 1.1 2.2OE-01 AF187850.1 NT Homo saplens PPAR delta gene, promoter region 2042 7155 12361 1.0 2.2OE-01 M34640.1 NT Fresh-water sponge Ernfl alpha collagen (COLF1) gene 2133 7243 12450 1.1 2.2012-01 A.1388469.1 NT Cobids taenla mitchonddal cyt b gene for cytochrome b 2853 8004 13102 4.0 2.2OE-01 BE1155625.1 EST-HUMAN PM2-HT0353-281299-003- a12 HT0353 Homo sapiens cDNA 2853 8004 13103 4.0 2.2OE-01 BE155625.1 EST-HUMAN PM2-HT0353-28129M03-a12 HT0353 Homo sapiens cDNA 2890 8041 1.6 2.2OE-01 AF020503.1 NT Homo saplens FRA3B common fragile region, diadenosine hiphosphate hydrolase (FHIT) gene,exon 5 3176 8325 13437 1.9 2.2OE-01 A1824368.1 EST-HUMAN tx69c09.xl NCI_PGAIR Utl Homo sapiens cDNA done IMAGE:2274832 3' 3346 8490 2.7 2.2OE-01 AL161562.2 NT Arabidopsis thallana DNA chromosome 4, config fragment No. 62 3743 8880 1.1 2.2OE-01 AF155728.1 NT YCIphophorus maculatus truncated Rexl retrotransposon reverse transcriptase (RT) pseudogene 4007 9138 14220 0.8 2.2OE-01 AF213391.1 NT Mus musculus ATP-binding cassette protein (Aticb8) mRNA, partial cds 4118 9244 1.2 2.2OE-01 AF1 19102.1 NT Drosophila melanogaster UNC-1 19 (uno-l 19) gene, complete cds 4125 9251 14332 5.1 2.2OE-01 AF155142.1 NT Mus musculus mixed lineage kinase 3 (M1k3) and two pore domain K+ channel subunit (Kcnk8) genes, complete cds 4166 9292 14372 2.0 2.2OE-01 AF1 17340.1 NT Mus musculus MAP kinase kinase kinase 1 (Mekkl) mRNA, complete cds 4166 9292 14373 2.0 2.2OE-01 AF1 17340.1 NT Mus musculus MAP kinase kinEise kinase 1 (MekkI) mRNA, complete cds 4258 9383 14465 1.2 2.2012-01 U01307.1 NT - - Human scIRNA (BC200 beta) pseudogene Page 27 of 196 Table 4

4258 9383 14466 1.2 2.2OE-01 U01307.1 NT Human scRNA (BC200 b ta) pseudogene 4399 9520 14610 1.1 2.2OE-01 Z54148.1 NT B.abortus bp26 gene 4719 9831 1.2 2.2OE-01 D50604.1 NT Human beta-cytoplasmic actin (ACTI3P9) pseudogene 4724 9836 14928 2.5 2.2OE-01 AA211216.1 EST-HUMAN zq87c05xl Stratagene hNT neuron (#937233) Horno saplens cDNA clone IMAGE:648968 5' 4891 9998 15081 1.2 2.2012-01 M86524.1 NT Human dystrophin gene 4975 10078 1.2 2.2012-01 L1 3299.1 NT Mus musculus vinculin gene, exon 3 532 5696 10819 0.6 2.1OE-01 AA827018.1 EST-HUMAN nr89909.sl NCI-C_Pr25 Horno sapiens cDNA done IMAGE:1175200 Ysimilar to gb223090 HEAT SHOCK 27 KI) PROTEIN (HUMAN); 532 5696 10820 0,6 2.1OE-01 AA827018.1 EST HUMAN nr89g09.sl NCI_PGAP_Pr25 Homo sapiens cDNA done IMAGE:1 175200 3'sImilar to gb223090 HEAT SHOCK 27 KI) PROTEIN (HUMAN); 955 6101 11259 0.6 2.1OE-01 AA569289.1 EST-HUMAN nm31el 1.sl NCI CGAP L1p2 Horno sapiens cDNA done IMAGE:1061804 958 6103 11261 0.9 2.1OE-01 AL161504.2 NT Arabidopsis thallana DNA chromosome 4, condg fragment No. 16 1108 6245 0.7 2.1OE-01 AE002314.2 NT Chlamydia muddarum, section 45 of 85 of the complete genome 1180 6313 11468 1.2 2.1OE-01 6754299 NT Mus musculus Interferon (alpha and beta) receptor 2 (Ifnar2), mRNA 1180 6313 11469 1.2 2.1OE-01 6754299 NT Mus musculus Interferon (alpha and beta) receptor 2 (Ifnar2), mRNA 1467 6594 11771 1.3 2.1OE-01 AE001988.1 NT Deinococcus radiodurans R1 section 125 of 229 of the complete chromosome 1 1792 6912 12097 1.4 2.1OE-01 6981303 NT Rattus norvegicus Olfactory marker protein (Omp), mRNA 1871 6989 12174 0.7 2.1OE-01 AA906824.1 EST HUMAN ok73e02.sli NCLWAP_GC4 Homo saplens cDNA done IMAGE.1519610 Ysimilar to gb:K02765 COMPLEMENT C3 PRECURSOR (HUMAN); 2894 8045 13145 1,7 2.1OE-01 6912445 NT Homo sapiens potassium voltage- gated channel, subfamily H (eag-related), member 4 (KCNI-14), mRNA 3218 8366 13478 2.0 2.1OE-01 AF06951 1.1 NT Rattus norvegicus putative sodium bicarbonate cotransporter (NBC) mRNA, complete cds 3967 9099 14183 1.0 2.1OE-01 P11675 SWISSPROT IMMEDIATE-EARLY PROTEIN 1E180 3967 9099 14184 1.0 2.1OE-01 P11675 SWISSPROT iMMEDIATE-EARLY PROTEIN 1E180 4279 9404 1.3 2.1OE-01 AB033041.1 NT Homo sapiens mRNA for, K1AA11 215 protein, partial cds 4474 9594 14689 1.2 2.1OE-01 A13010273.1 NT Homo sapiens pshsp47 gene, complete cds 4766 9877 14971 1.3 2.1OE-01 AJ009794.1 NT Horno sapiens hoxl 1 proto- oncogene, exons 1 to 3 and hug-1 gene 5134 10229 15304 1.0 2.1OE-01 M98261.1 NT Saccharomyces cerevislae taul38 (TFC3) gene, complete ods 193 5387 10515 0.6 2.OOE-01 A13017437.1 NT Gallus gallus mRNA for avena, complete cds 365 5543 10675 0.9 2.OOE-01 A1475599.1 EST HUMAN tc92g12.yl NCI-CGAP-CL-1. 1 Homo sapiens cDNA done IMAGE:2073670 Wsimilar to contains Alu repetitive element; 365 5543 10676 0.9 2.OOE-01 A1475599.1 EST-HUMAN tc92g12.yl NCLWAP CL1.1 Homo sapiens cDNA clone IMAGE:2073670 5'similar to contains Alu repetitive element; 523 5687 0.8 2.OOE-01 7705601 NT Homo saplens CGI-18 protein (LOC51008), mRNA 684 5839 10972 1.2 2.0OE-011 M77085.1 NT O.cunniculus germline 19H heavy chain V-H pseudogene, allotype V1-1a2 793 5944 11095 0.6 2.OOE-01 AF027865.1 NT Mus musculus Major Histocompadbility Locus class 11 region 995 6137 11291 1.0 2.OOE-01 D90905.1 NT Synechocys s sp. PCC6803 complete genome, 7127, 781449-920915 1082 6220 11371 1.3 2.0OE-01 4826749 NT Homo sapiens A kinase (PRKA) anchor protein (gravin) 12 (AKAP12), mRNA 6246 11398 0.9 2.OOE-01 AL163213.2 NT Homo sapiens chromosome 21 segment HS21 C01 3 Page 28 of 196 Table 4

1234 6363 11525 1.4 2.OOE-01 A.1132695.5 NT - Homo sapiens racl gene 1286 6416 11579 1.3 2.OOE-01 AW384937.1 EST HUMAN PM1-HT0422.29129"02-c06 HT0422 Horno sapiens cIDNA 1419 6547 11721 0.8 2.0OE-011 M64239.11 NT Mouse T-cell receptor alphaldelta chain locus 1419 6547 11722 0.8 2.OOE-01 M64239.1 NT Mouse T-cell receptor alphaidelta chain locus 1471 6598 11773 4.9 2.0OE-011 4503408 NT Homo sapiens dystrobrevin, alpha (DTNA), mIRNA 1534 6660 11827 0.9 2.OOE-01 A13007974.1 NT Homo saplens mRNA, chromosome 1 specific transcript KIAA0505 1538 6664 11832 0.6 2.OOE-01 AF260700.11 NT Homo sapiens sod(umflodide symporter mRNA, partial ods 1688 6812 0.7 2.OOE-01 AF1 11170.3 NT Homo sapiens 114g32 Jagged2 gene. complete cd!; and unknown gene 1723 6846 0,6 2.OOE-01 U67525.1 NT Methanococcus jannaschil section 67 of 1 W of the complete genome 2299 7403 0,6 2.0012-01 X82877.1 NT H.sapiens Na±D-glucose cotransport regulator gene 2861 8012 1.0 2.OOE-01 AF074990.11 NT Homo sapiens full length Insert cDNA YH85A1 1 3442 8584 13698 0.8 2.0OE-01 P46607 SWISSPROT HOMEOBOX PROTEIN GLABRA2 (HOME0BOX-LEWNE ZIPPER PROTEIN ATHB-10) (HD-ZIP PROTEIN ATHB-10) 3520 8661 0.9 2.OOE-01 AW238005.1 EST HUMAN xp15b02.xl NCI CGAP_HN9 Homo sapiens eDNA clone IMAGE:2740395 Ysimilar to contains elemeit MER21 repetitive element; 3646 8785 13878. 0.8 2.OOE-01 P34641 SWISSPROT CED-1 1. PROTEIN 3945 9078 14160 0.8 2.OOE-01 X83997.1 NT C.parasifica eapC gene 4367 9489 14580 0.9 2.OOE-01 AF060195.1 NT Mus musculus proteasome regulator PA28 beta subunit gene, complete cds 4859 9966 15051 1.1 2.OOEM AF147083.1 NT Homo saplens gamma-glutamy] hydrolase gene, exons 8 and 9 and complete cds 4972 10075 15148 6.1 2.OOE-01 8922080 NT Homo sapiens hypothetical protein ASH1 (ASHI), mRNA 5041 10141 15219 1.1 2.OOE-01 Y19216.1 NT Homo sapiens putative psihHbD pseudogene for hair keratin, exons 1 to 9 5308 3.5 1.9OE-01 7549743 NT Rattus norvegicus Aryl hydrocarbon receptor nuclear translocator 1 (Amti), mRNA 349 5530 10658 2.0 1.9OE-01 AF004353.11 NT Mus musculus pale ear (ep) gene, vAld type allele, 31 region, partial cds 470 5635 10764 0.7 1.9OE-01 043474 SWISSPROT KRUPPEL-LIKE FACTOR 4 (EPiTHELIAL ZINC-FINGER PROTEIN EZF) 640 5799 10924 1.3 1.9OE-01 U32581.2 NT Homo sapiens lambdaAota Rrotein kinase C-Interacting protein mRNA, complete cds 640 5799 10925 1.3 1.9OE-01 U325811.2 NT Homo saplens lambda/lota protein kinase C-Interacting protein mRNA, complete cds 647 5806 10932 1.8 1.9OE-01 BE070801.1 ESTHUMAN RC3-13T0502-251 199-011 A01 BT0502 Homo sapiens cDNA 648 5806 10932 2.5 1.9OE-01 BE070801.1 EST-HUMAN RC3-13T0502-2511 199-01 1-d01 BT0502 HomJsapiens cDNA 970 6115 0.6 1.9OE-01 7305180 NT Mus musculus Interieukin 2 receptor, gamma chain (112rg), mRNA 1088 6226 11378 3,2 1.9OE-01 AA358813.1 EST HUMAN EST67784 Fetal lung 11 Horno, sapiens cDNA Vend 1348 6476 11642 0.8 1.9OE-01 AF061282.1 NT Sorghum bicolor 22 kDa kafidn cluster 1416 6544 1.4 1.9OE-01 AF184623.1 NT Plasmodium vivax reficulocyte binding protein-2 (rbp-2) gene, complete cds 1873 6991 12176 -0.6 1.9OE-01 AW821631.1 EST-HUMAN]L2-ST0311-270300- 059E04 ST0311 Horno sapiens cDNA 1928 7045 12236 0.9 1.9OE-01 AF2611940.1 NT Spinacia oleracea AJwarodbosomal protein 5 precursor (Psrp-5) mRNA, complete ods; nuclear gene for chloroptast product 2330 7433 12641 1.2 1.9OE-01 8922533 NT Homo sapiens hypothetical protein FLJ10581 (FL.110581), mRNA 2892 8043 13143 3.9 1.9OE-01 U66066.1 NT Sigmodon hispidus p53 gene, partial cds 2908 8058 5.6 1.9OE-01 J00922.11 NT G;1lus gallus ovalbumin (Y) gene, complete cds 3349 8493 13604 3.4 1.9OE-01 D13197.1 NT Mouse gene for lmmunoglobulin diversity region D1 3434 8576 13688 4.6 1.9OE-01 R16467.1 EST_HUMAN yf42f10xl Soares fetal liver spleen 1 NFLS Homo sapiens cDNA clone IMAGE:129547 5' Page 29 of 196 Table 4

Page 30 of 196 3735 8872 13964 0.9 1.9OE-01 AF264017.1 NT Rattus norvegicus aryfacetamide deacetylase gene, complete cds 3762 8900 13989 1,0 1.9OE-01 P39768 SWISSPROT PAIR-RULE PROTEIN ODD- PAIRED 3910 9045 14132 3,0 1.9OE-01 A13006784.1 NT Schizosaccharomyces pombe DNA for c)doplasmic dynein heavy chain, complete eds 3992 9124 14208 1,9 1.9OE-01 AW754106.1 EST HUMAN CM3-CTO315-271199-045- bl 1 CT0315 Homo sapiens cDNA 4369 9491 14581 0.9 1.90E-01 AL1 61493.2 NT Arabidopsis thallana DNA chromosome 4, config fragment No. 5 4662 9774 14870 0.8 1.9OE-01 Z93780.1 NT Fugu rubripes genes encoding carbamoyl phosphate synthetase Ill, myosin light chain, MAP2 4663 9775 14871 2.4 1.9OE-01 AW821631.1 EST HUMAN IL2-ST0311-270300-059- E04 ST0311 Homo sapiens cDNA 4857 9964 15049 2.1 1.9OE-01 U31785.1 NT Human papillomavirus type 36, complete genome 4912 10019 15098 0.9 1,9OE-01 AW849203.1 EST HUMAN IL3-CTO215-180200-087- DO2 CT0215 Horno saplens cDNA 4943 10049 1.0 1.90E-01 AF223642.1 NT Rattus norvegicus chemokine receptor CXCR3 mRNA, complete cds 4962 10065 15137 1.1 1.90E-01 095239 SWISSPROT KINESIN-LIKE PROTEIN KIF4 5113 10209 15287 1,0 1.9OE-01 Z70296.11 NT S.mansoni elastase HP1 gene 5123 10219 1.2 1.90E-01 A1631199.1 EST-HUMAN ts93g112.xl NCI_CGAP-GC6 Homo sapiens cDNA done IMAGE:2238886 X similar to gb..M21574 ALPHA PLATELET-DERIVED GROWTH FACTOR RECEPTOR PRECURSOR (HUMAN); 5153 10248 15321 1.0 1.9OE-01 6679095 NT Mus musculus Notch gene homolog 3, (Drosophila) (Notch3), mRNA 17 5226 10327 0,7 1.8OE-01 X79037.1 NT H.sapiens Y315 gene 29 5238 10343 0.8 1.80E-01 U73200.1 NT Mus musculus pl 16Rip mRNA, complete cds 260 7885 10573 1.2 1.8OE-01 A13022090.1 NT Mus musculus Ccl:g gene for Chaperonin containing TCP-1 gamma subunit, partial cds 366 5544 10677 0.8 1.8OE-01 4502532 NT Homo sapiens calcium channel, voltage-dependent, beta 2 subunit (CACNB2) mRNA, and translated products 729 5883 11025 0.7 1.80E-01 A13021490.2 NT Oryzias ladpes gene for membrane quanylyl cyclase OIGC1, complete cels 966 6111 11267 0,9 1.8OE-01 A1912212.1 EST HUMAN wd71f02.xl NCI CGAP Lu24 Homo sapiens cDNA clone IMAGE:2337051 3' 1075 6212 11364 1.2 1.8OE-01 AF000580.1 NT Dictyostellum discoldeum plasmid Ddip5, complete genome 1267 6396 11556 1.8 1.8OE-01 AL1 17189.1 NT Yersinia pestis plasmid pCD1 1487 6614 11784 1.3 IffiE-01 6753947 NT Mus musculus guanylate nudeofide binding protein 1 (Gbpl), mRNA 1487 6614 11785 1.3 1.8OE-01 6753947 NT Mus musculus quanylate nudeofide binding protein 1 (Gbpl), mRNA 1803 6922 0.9 1.80E-01 4505036 NT Homo saplens latent transforming growth factor beta binding protein 4 (LTBP4) mRNA 1823 6942 0.7 1.8OE-01 A1733708.1 EST-HUMAN qg22d10.x5 NCI_CGAP_KJd3 Homo sapiens cDNA clone IMAGE:1761811 X similar to TR:075936 075936 GAMMA BUTYROBETAINE HYDROXYLASE; 2421 7520 1.5 1.8OE-01 J03216.1 NT Ti plasmid virB operon encoding twelve virulence genes, complete cds 2660 7749 1.1 1.8OE-01 AW935728.1 EST-HUMAN W3-DT001 8.081299-036-904, DT001 8 Homo saplens cDNA 2868 8019 1.6 1.8OE-01 AF184589.1 NT Jonopsidium acaule LEAFY protein (LEAFY2) gene, partial cds 2873 8024 13127 1.1 1.8OE-01 AW182300.11 ESTHUMAN x1411a03.xl Soares_NIFIL T GBC S1 Horno sapiens cDNA done IMAGE:2659756 31 3006 8158 4.9 1.8OE-01 P13983 SWISSPROT EXTENSIN PRECURSOR (CELL WALL HYDROXYPROLINE-RICH GLYCOPROTEIN) 3040 5226 10327 2.0 1.8OE-01 X79037.1 NT H.sapiens 15 gene 3085 8236 13335 -1.3 1.80E-01 AW995178.1 ESI_HUMAN QVO-BN0041-070300-147- c04 BN0041 Homo sapiens cDNA 3570 8709 13807 1,1 1.80E-01 H03369.11 EST HUMAN yj45e0I.sl Soares placenta Nb2HP Homo sapiens cDNA clone IMAGE:151704 Ysimilar to contains Alu repetitive element; Table 4

3570 8709 13808 1.1 1.8OE-01 H03369.1 EST HUMAN yj45e01.sl Scares placenta Nb2HP Homo sapiens cDNA clone IMAGE:151704 Ysimilar to contains Alu repetitive element 4154 9280 14360 0.8 1.8OE-01 AJ271735.1 NT Homo sapiens Xq pseudoautosornal. region; segment 112 4238 9363 1.1 1.8OE-01 D37954.1 NT Bovine NB25 mRNA for MI-IC class 11 (SoLA-DOB). complete ods 4456 9576 14673 5.1 1.8OE-01 AL-161556.2 NT Arabidopsis thallana DNA chromosome 4, condg fragment No. 56 4595 9709 14801 1.1 1.8OE-01 U17755.1 NT Human laminin S B3 chain (LAMB3) gene, exon 13 4700 9812 14909 0.9 1.8OE-01 X92179.1 NT S.tuberosum mRNA for alcohol dehydrogenase 4977 10080 15150 1 98 1.8OE-01 AW814270.1 EST HUMAN MR3-ST0203-151299-112- 906 ST0203 Homo sapJens cDNA 5027 10128 15202 4.2 1.8OE-01 AF181258.1 NT Mesocricetus auratus Na- taurocholate cotransporting polypeptide mRNA, partial cds 5053 10153 15229 1.3 1.8OE-01 A1439881.1 EST HUMAN U57e04.xl NCI_PGAP)212 Homo saplens cDNA done IMAGE:2134590 3' 5117 10213 1.0 1.8OE-01 AJ000742.1 NT Homo Sapiens hisHI gene, VUM 563 5725 10841 0.6 1.7OE-0.1 BE385164.1 EST-HUMAN 601274604F1 NIH MGQ_20 Homo sapiens cDNA done iMAGE:3615768 5' 788 5939 11091 0.7 1.70E-01 X53330.1 NT P.dumedill histone gene duster for core hIstones H2A, H2B. H3 and H4 945 6092 0.6 1.7OE-01 P35616 SWISSPROT NEUROFILAMENT TRIPLET L PROTEIN (NEUROFILAMENT LIGHT POLYPEPTIDE) (NF-Q 1042 6182 11334 0.6 1.70E-01 AF081810.1 NT Lymantria disear nudeopolyhedrovirus, comelete genome 1042 6182 11335 0.6 1.70E-01 AF081810.1 NT Lymantria dispar nucleopolyhedrovirus, complete genorne 1938 7055 1.4 1.70E-01 AF255051.1 NT Horno sapiens 8NIP3H (BN1P3H) gene, complete cds; nuclear gene for mitochondrial product - 7980 13080 1.9 1.70E-01 AF000716.1 NT Vibrio cholerae hypoxanthine phosphoribosyitransferase (hpt) gene, partial ods, 2829 hemaggludnin/protease regulatory protein. (hapR) gene, complete ods, and YRAL V113C0 gene, partial cds 2829 7980 13081 1 1.70E-01 AF000716.1 NT Vibrio cholerae hypoxanthine phosphodbosyltransferase (hpt) gene, partial ods, hemagglutnin/protease regulatory protein (hapR) gene, complete ods, and YRAL VIBCO gene, partial cds 2896 8047 13148 1.7 1.70E-01 AA336909.1 EST-HUMAN EST41651 Endometrial tumor Homo sapiens cDNA Vend 8118 13225 1.4 1.7OE-01 A.1238736.1 NT Nala naja atra ctK-1 gene, exons 1- 3 -2967 8118 13226 1.4 1.7OE-01 AJ238736.1 NT NAa naja atra ctx-1 gene, exons 1-3 3067 8218 13317 1.9 1.70E-01 AF081514.1 NT Taxus canadensis geranAgeranyl diehosphate synthase mRNA, complete ods 3076 8227 13325 2.3 1.70E-01 AB015873.1 NT Orydas latipes mRNA for quanylate cyclase MC-Rl, complete ods 3076 8227 13326 2.3 1.70E-01 A8015873.1 NT Orydas ladpes mRNA for quanylate cyclase OIGC-Rl, complete ods 3557 8696 13794 1.0 1.70E-01 AJ224877.1 NT Homo saplens hapI gene, complete CDS 3859 8995 14094 4.4 1.70E-01 AJ235377.1 NT Homo sapiens derivative 11 breakpoint fragment: partial Intron 10 of the ALL-1/MLUHRX gene fused to fritron 5 of the AF-41FEL gene 4459 9579 1.9 1.70E-01 X52936.1 NT Schistocerca gregarla alpha repetitive DNA 4732 9843 14935 1.4 1.70E-01 A1247635.1 EST-HUMAN qh57c09.xl Soare_fetaUlvey_spleen-1 NFI-S-S1 Horno sapiens cl) done IMAGE:1848808 Y similar to contains OFR.bl OFR repetitive element; 4986 10089 1.2_ 1.70E-01 U28376.1 NT Zea mays caldum-dependent protein kinase (MZECDPK2) mRNA, complete ods 5067 10165 1.2 1.7OE-01 AF072725.1 NT Zea mays starch branching enzyme lib (ae) gene, complete ods 5319 10449 0.6 1.60E-01 AF217532.1. NT Homo saplens mevalonate kinase gene, exon 6 and 7 664 7863 10948 0.5 1.60E-01 R31497.1 EST-HUMAN yh75f12.rl Scares placenta Nb2HP Homo sapJens cDNA done IMAGE:1 35599 5' 670 5826 10953 1.1 1.60E-01 084224.1 NT Homo sapiens mRNA for methlonyl IRNA synthetase. complete cds Page 31 of 196 Table 4

1882 7000 12185 0.9 1.60E-01 P22063 SWISSPROT AXONIN-1 PRECURSOR (AXONAL GLYCOPROTEIN TAG-1) 1941 7058 1.0 1.60E-01 U10334.1 NT Crassostrea gigas RNA polymerase 11 largest subunit mRNA, partial cds 2247 7353 12560 1.8 1.60E-01 AF109907.1 NT Homo sapiens S164 gene, partial ods; PSI and hypothetical protein genes, complete cds; and S171 gene, partial cdp 2335 7941 12647 1.0 1.60E-01 X94232.1 NT H.sapiens mRNA for novel T-cell activation protein 2443 7542 12750 0.8 1.6012-01 AB037729.1 NT Homo sapiens mRNA for K1AA1 308 protein, partial cds 2863 8014 13115 8.9 1.60E-01 AF185589.1 NT Homp sapiens cytochrome P450 3A4 (CYP3A4) gene, promoter region 2863 8014 13116 8.9 1.60E-01 AF1185589.1 NT Homo saplens cytochrome P450 3A4 (CYP3A4) gene, promoter region 3581 8720 13817 1.3 1.60E-01 AJ003165.1 NT Populus trichocarpa cv. Trichobel B13 gene 3581 8720 13818 1.3 1.60E-01 AJ003165.1 NT Populus trichocarpa cv. Trichobel AB13 gene 3583 8722 0.9 1.6OE-01 A1810954.1 EST HUMAN tuOgfOg.xl NCI CGAP Pr28 Horno sapiens cIDNA done IMAGE:2250569 3, 4234 9358 14440 7.9 1.6OE-01 AF1 79680.1 NT Homo sapiens apelin gene, complete eds 4249 9374 14454 4.0 1.6OE-01 AL163279.2 NT Homo saplens chromosome 21 segment HS21C079 4353 9475 2.4 1.60E-01 AW968601.1 EST - HUMAN EST380677 MAGE resequences, MAGJ Horno sapiens cDNA 4361 9483 4.0 1.60E-01 6753319 NT Mus musculus chaperonin subunit 3 (gamma) (Cct3), mRNA 4781 9891 14983 0.9 1.6OE-01 Z28330.1 NT S.cerevislae chromosome XI reading frame ORF YKR105c 4781 9891 14984 0.9 1.60E-01 Z28330.1 NT S.cerevisiae chromosome XI readin2 frame ORF YKR1 05c 4846 9953 15042 7.1 1.60E-01 AF187881.1 NT Homo sapiens leukointegrin alpha d gene, promoter and partial eds 4865 9972 15056 1.1 1.60E-01 AA088343.1 EST HUMAN d84h09.sl Stratagene colon (#937204) Horno sapiens cDNA clone IMAGE:511361 3' similar to TR:E221955 E221955 38,855 BP SEGMENT OF CHROMOSOME XIV.; 4889 9996 15078 1.9 1.60E-01 AJ006356.1 NT Lycopersicon iculentum Rsal fragment 2, satellite region 4889 9996 15079 1.9 1.6012-01 AJ006356.1 NT Lycopersicon esculenturn Rsal fragment 2, satellite region 4958 10061 15133 1.1 1.60E-01 BE018707.1 EST HUMAN bb83h08.yl N11-1-MGC10 Horno sapiens cDNA clone IMAGE:3049023 5'similar to gb:M61715 TRYPTOPHANYL-TRNA SYNTHETASE (HUMAN); gb:X69657 M.musculus (MOUSE); 567 5728 10845 0.7 1.50E-01 U34206.1 NT Cricetulus griseus 170 kDa glucose regulated protein (9rp170) mRNA, complete cds 766 5919 11066 1.4 1.5OE-01 AL163284.2 NT Homo sapiens chromosome 21 segment HS21C084 1076 6214 11366 0.9 1.5012-01 A.1009735.1 NT Cyprinus carpio mRNA for EGGS22 myosin heavy chain, Y1.1TR 1081 6219 11370 0.6 1.50E-01 AJ251885.1 NT Homo sapiens partial SLC22A2 gene for organic cation transporter (OCT2), exon 1 1097 6235 0.6 1.50E-01 L36125.1 NT Rattus norvegicus Insulin-responsive glucose transporter (GLUT4) gene, Vend 1104 6242 11395 1.0 1.5OE-01 012697 SWISSPROT PROBABLE CATION- TRANSPORTING ATPASE 9 1198 6330 11485 1.4 1.5OE-01 AW195516.1 EST HUMAN xn39dl 1.xl NCI CGAP Kidl 1 Homo sapiens cDNA done IMAGE:2696085 3, 1254 6383 11542 1.0 1.50E-01 D26535.1 NT Human gene for dihydrolipoamide sucdnyitransferase, complete cds (exon 1-15) 1254 6383 11543 1.0 1.50E-01 D26535.1 NT Human gene for dihydrolipoamide succJnyitransferase, complete cds (exon 1-15) 1466 6593 11770 0.5 1.5OE-01 AF1 17340.1 NT Mus musculus MAP kinase kinase kinase 1 (Mekkl) mRNA, complete cds 1866 6984 12168 0.6 1.5OE-01 AW444451.1 EST HUMAN Ul-H-BI3-akb-b-09-0-Ul. sl NCI-CGAP-Sub5 Homo sapiens cDNA clone IMAGE:2733641 3' 2999 8151 13251 0.9 1.5OE-01 M81441.1 NT Bos taurus factor V variant 2 (factor V) mRNA, complete cds 3013 8165 13266 3.5 1.5OE-01 P01138 SWISSPROT BETA-NERVE GROWTH FACTOR PRECURSOR (BETA-NGF) 3308 8453 13566 4.2 1.5OE-01 AA935049.1 EST HUMAN oo68d05.sl NCI-CGAP-GC4 Homo sapiens cDNA clone IMAGE:1571337 Ysimilar to gb:Ml 1433 RETINOL-BINDING PROTEIN 1, CELLULAR (HUMAN); Page 32 of 196 Table 4

3322 8466 13580 0.9 1.5OE-01 Z23104.1 NT L.stagnalls mRNA for G proteincoupled receptor 3322 8466 13581 0.9 1.5OE-01 Z23104.1 NT L.stagnalls mRNA for G protein- coupled receptor 3380 8523 13629 1.0 1.50E-01 AW612237.1 EST HUMAN hh29f02.xl NCI_CISAP-1- 1.124 Homo sapiens cDNA done IMAGE:2956539 Ysimilar to contains element MER16 repetitive element; 3696 8835 13926 1.3 1.50E-01 U09964.1 NT Mus musculus ICRISvAss glyceraldehyde 3-phosphate dehydrogenase, (Gapd-S) gene, complete cds 3706 8844 13935 185.3 1.5OE-01 7108358 NT Homo sapiens pyruvate dehydrogenase kinase, Isoenzyme 1 (PDK1), nuclear gene encoding mitochondrial protein, mRNA 3791 8928 14022 2.4 1.5OE-01 AW665983.1 EST HUMAN hj10106,xl Soares_NFL_T_GBC S1 Horno sapiens cDNA clone IMAGE:2961411 3, 3806 8943 14038 0.8 1.50E-01 AJ003165.1 NT Populus trichocarpa cv. TrichoW AB13 gene 3806 8943 14039 0.8 1.5OE-01 AJ003165.1 NT Populus trichocarpa cv. Trichobel AB13 gene 3964 9096 14181 1.0 1.5OE-01 AW366659.1 EST-HUMAN RC2-HT0149-191099-012c09 HT0149 Homo saplens cDNA 4006 9137 14219 1.0 1.50E-01 Z12628.1 NT B,napus mitochondhon DNA for ORF158 4091 9217 14300 8.4 1.50E-01 AL163284.2 NT Horno sapiens chromosome 21 segment HS21 C084 4680 9792 14893 1.1 1.50E-01 BE173796.1 EST HUMAN CMO-HT0565-280200-245- b10 HT0565 Homo sapiens cDNA 4680 9792 14894 1,1 1.50E-01 BE173796.1 EST HUMAN CMO-HT0565-280200-245- b10 HT0565 Horno sapiens cDNA 4929 10036 15108 1.3 11.5012-01 AL161560.2 NT Arabidopsis thaliana DNA chromosome 4, contiq fragment No. 60 5072 10170 15248 0.9 1.5OE-01 AF003105.1 NT Arabidopsis thallana AP2 domain containing protein RAP2.12 mRNA, partial cds 296 5482 0.7 1.40E-01 AF009663.11 NT Horno sapiens T cell receptor beti locus, TCRI3V8S512 to TCRBV21S2A2 region 892 6040 0.9 1.40E-01 D78638.11 NT Xenopus laevis mRNA for DNA (cytosine- 5-methyitransferase, complete cds 1238 6367 0,6 1.40E-01 T91864.1 EST HUMAN yd54c0I.sl Scares fetal liver spleen INFLS Homosaplens cDNA clone IMAGE:112032 3' 1714 6837 0.5 1.40E-01 6679980 NT Mus musculus growth differentiation factor 5 (Gdf5), mRNA 1717 6840 12019 0.6 1.40E-01 AE001710.1 NT Thermotoga marifirna section 22 of 136 of the complete genorne 1863 6981 0.9 1.40E-01 AW135741.1 EST HUMAN Ul-H-Bil-acf-a-09-0-Ul.sl NCI- CI3AP_SuW Homo sapiens cDNA clone IMAGE:2714009 3 1942 7059 3.7 1.40E-01 AA72061 5.1 EST HUMAN ny72d07.sl NCI CGAP GCB1 Homo sapiens cDNA done IMAGE:1283821 3' 2426 7525 12731 1.0 1.4011-01 P30706 SWISSPROT GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE PRECURSOR (GPAT) 2762 7846 13049 1.1 1.40E-01 A1933496.1 EST-HUMAN wm74d01.xl NCI CGAP_Ut2 Homo sapiens cDNA done IMAGE:2441665 3' 3823 8960 14056 1.0 1.40E-01 R59232.1 EST HUMAN y997a03xl Scares infant brain 1 NIB Homo sapiens cDNA clone IMAGE:41467 5, 3823 8960 14057 1.0 1.40E-01 R59232.1 EST-HUMAN yg97a03xl Soares Infant brain 1 NIB Homo sapiens cDNA done IMAGE:41467 5' 4083 9210 14294 8.4 1.40E-01 A1699094.1 EST HUMAN tx56c02.xl NCI WAP.Lu24 Homo saplens cDNA done IMAGE:2273570 3' 4083 9210 14295 8.4 1.40E-01 A1699094.1 EST HUMAN tx56c02.xl NCI CGAP Lu24 Horno, sapiens cDNA clone IMAGE:2273570 3, 4144 9270 14349 3.2 1.40E-01 AE001710.1 NT Thermotoga marifirna section 22 of 136 of the complete genome 4313 9436 0.8 1.40E-01 AA776287.1 EST HUMAN zj50b01.sl Soare!_fetal-liver- spleen_l NFI-S-S1 Homo sapiens cDNA clone IMAGE:453673 Ysimilar to gb:X01057_rnal INTERLEUKIN-2 RECEPTOR ALPHA CHAIN PRECURSOR (HUMAN);contains AW repetitive element; 4803 9913 1.2 1.4012-01 AL049866.2 NT Mus musculus chromosome X conbgB; X- linked lymphocyte regulated 5 gene, Zinc finger protein 275, Zinc finger protein 92, mmxq28orf 5032 10132 0.9 1.40E-01 AW866022.1 EST HUMAN QV3-SNO022-100500-186-h09 SNO022 Homo sapiens cDNA 5116 10212 1529 1.0 1.40E-01 AL163284.2 NT Homo sapiens chromosome 21 segment HS21 C084 M.

(1 Page 33 of 196 Table 4

5147 10242 15316 0.8 1.40E-01 AJ005180.11 NT Lycopersicon esculenturn genornic RAPID band 26 319 5503 10630 0.9 1.30E-01 4758467 NT Homo saplens G protein-coupled receptor 50 (GPR50) mRNA 319 5503 10631 0.9 1.30E-01 475M7 NT Homo sapiens G protein-coupled receptor 50 (GIPR50) mRNA 518 5682 10803 0,6 1.30E-01 AB013139.1 NT Homo sapiens gene for NBS1, complete cds 620 5779 10901 0.9 1.30E-01 A.1277606.1 NT Human calidvirus HUINLV/GidingtonlgYUK RNA for capsid protein (ORF2), strain HUINLV/Gidington/93/UK 620 5779 10902 0.9 1.30E-01 AJ277606.1 NT Human calicivirus HUINLV/Gidington/93/UK RNA for capsid protein (ORF2), strain HU/NLV/Gidington/93/UK 826 5975 11135 1.1 1.30E-01 X53330.1 NT P.dumedill histone gene duster for core histones H2A, H2B, H3 and H4 876 6024 11184 0.6 1.30E-01 AF139518.1 NT Rattus norvegicus A-kinase anchor.proteln mRNA, complete cds 1010 6166 11303 0.5 1.3OE-01 AL1 17078.1 NT Botryds dnerea strain T4 cDNA library under conditions of nitrogen deprivation 1111 6248 0.8 1.30E-01 AL1 15265.1 NT Bo"s dnerea strain T4 cDNA library under conditions of nitrogen deprivation 1426 6553 1.4 1.30E-01 AF146277.1 NT Homo sapiens adapter protein CIVIS mRNA, complete ods 1916 7033 12221 0.9 1.30E-01 AL1 17078.1 NT Botryds dnerea strain T4 cDNA library under conditions of nitrogen deprivation 2124 7234 1.3 1.30E-01 AJ243578.1 NT Rhodopseudomonas addophila pucB5, pucA5, pucB6, pucA6, pucB7, pucA7, pucB8, pucA8 and pucC genes and ORF151 2245 7351 1.2 1.30E-01 AW812104.1 EST HUMAN RC4-ST0173-191099-032-d12 ST0173 Homo sapiens cDNA 2329 7432 1.1 1.30E-01 AE001016.1 NT Archaeoglobus fulgidus section 91 of 172 of the complete genome 2542 7638 12838 1.3 1.30E-01 M86918.1 NT Carasslus auratus keratin type 1 mRNA, complete cds 3404 8546 13654 1.0 1.30E-01 M21572.1 NT Bovine branched chain alpha-keto add dthydrolipoyl transacylase mRNA, complete cdS 3661 8800 13894 1.2 1.30E-01 AP000001.1 NT Pyrococcus horikoshil OT3 genomic DNA, 1-287000 nt. position (117) 3661 8800 13895 1.2 1.30E-01 AP000001.1 NT Pyrococcus horikoshii OT3 genomic DNA, 1-287000 nt. position (V7) 3667 8806 13900 0,8 1.30E-01 AB0321 59.1 NT Homo sapiens DD4 gene for dihydrodiol dehydrogenase 4 fAKR 1 C4), exon 2 3714 8800 13894 0.9 1.30E-01 AP000001.1 NT Pyrococcus horikoshil OT3 genomic DNA, 1-287000 nt. position (117) 3714 8800 13895 0.9 1.30E-01 AP000001.1 NT Pyrococcus hodkoshil OT3 genomic DNA, 1-287000 nt. position (117) 3734 8871 13963 0.9 1.30E-01 6978840 NT Rattus norvegicus Fibrinogen, gamma polypepfide (F9g), mRNA 3906 9041 1.7 1.30E-01 AL161581.2 NT Arabidopsis thallana DNA chromosome 4, config fragment No. 77 4046 9173 1.2 1.30E-01 AF020713.1 NT Bacteriophage SPBc2 complete genome 4066 9193 3.4 1.30E-01 AW364341.1 EST HUMAN QV3.DT0018-081299-036-a03 DT0018 Horno saplens cDNA 4075 9202 14288 1.9 1.30E-01 AF026805.1 NT Schistosoma mansoni fructose bisphosphate aldolase mRNA, complete cds 4093 9219 14302 16.4 1.309-0-1 AW273741.1 EST-HUMAN xv23f10.xl Soares_NFL. T GBC S1 Homo sapiens cDNA clone IMAGE:2813995 3' 4218 9342 1.7 1.30E-01 AL.163280.2 NT Horno saplens chromosome 21 segment HS21 C080 4433 9554 14648 2.2 1.3012-01 BE272339.1 EST-HUMAN 601126096F1 N1H MGC 9 Homo saplens cDNA done IMAGE:2990063 5' 5074 10172 15250 1,2 1.30E-01 AL163284.2 NT Homo saplens chromosome 21 segment HS21 C084 5074 10172 15251 1.2 1.30E-01 AL1 63284.2 NT Homo sapiens chromosome 21 segment HS21 C084 5103 10199 15279 0.9 1.30E-01 Z73419.11 NT Mycobacterlum tuberculosis H37Rv complete genome; segment 571162 378 5584 10717 2.5 1.20E-01 A1421744.1 EST HUMAN tf39b02.xl NCI CGAP - 13m23 Homo sapiens cDNA done IMAGE:2098539 3'simitar to gb:U05760 mal ANNEXIN V (HUMAN); 418 5207 0.5 1.20E-01 U66912.1 NT DictVosteliurn discoldeum ORF DG1016 gene, partial ods 535 5698 0.9 1.20E-01 AF039442.1 NT - Homo sapiens colon cancer antigen NY-CO-45 mRNA, partial cds Page 34 of 196 1490 6617 1.1 1.2012-01 AA897474.1 EST HUMAN a148e09.sl Soares_NFL T GBC 8.1 Horno sapiens cDNA done IMAGE:1460584 3'similar to TR:Q1 6671016671 NTI-MUjLERIAN HORMONE TYPE 11 RECEPTOR PRECURSOR.; 1613 6739 11909 1.2 1.20E-01 Q14934 SWISSPROT NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4 (T CELL TRANSCRIPTION FACTOR NFAT3) (NF-ATC4) (NF-AT3) 1631 6757 11928 1.0 1.20E-01 A1285402.1 EST HUMAN qt69109.xl NCI CGAP. Aso2 Homo saplens cDNA done IMAGE:1960553 3, 1730 6893--- 11.0 1.20E-01 X8921 1.1 NT H.sapiens NA for endogenous retroviral like element 1739 6862 0.6 1.20E-01 U41418.1 NT Vibrio furnissli chitodextdnase gene, complete cds 1 B77 6995 0.5 1.20E-01 AW449368.1 EST HUMAN U[-H-B13-aki-e-10-0-Ul.sl NCI_.CGAP_Sub5 Homo saplens cDNA clone IMAGE:2734554 3' 2240 7346 12557 1.0 1.20E-01 AL163213.2 NT Homo sapiens chromosome 21 segment HS21C013 2546 7642 12842 0.7 1.20E-01 AW996556.1 EST-HUMAN OV3-BN0046-220300129410 BN0046 Homo saplens cDNA 2697 7783 12983 0.9 1.20E-01 A1623388.1 EST HUMAN tsl8g07.xl NCI CGAP_panl Homo sapiens cDNA clone IMAGE:2228988 Ysimilar to TR:Q14048 Q1Z048 COLLAGEN VI ALPHA-2 ALTERNATIVE C-TERMINAL DOMAIN. 11) contains element PTR5 repetitive element; 2812 7963 13069 1.5 1.20E-01 U18018.1 NT Human E1A enhancer binding protein (E1A-F) mRNA, partial cds 2872 8023. 13126 100 1.20E-01 A1720470.1 EST HUMAN as80c09.xl Barstead colon HPI-RS7 Homo sap(ens cDNA clone IMAGE:2335024 Ysimilar to gb105095 60S RISOSOMAL PROTEIN L30 (HUMAN); 2904 8055 13160 2.9 1.20E-01 M16364.1 NT Human creadne kinase-B mRNA, complete ods 2974 8125 13232 1.0 1.20FE-01 X56882.1 NT Wheat mRNA for a group 3 late embryNenesis abundant protein (LEA) 3177 83M. 13438 2.0 1.20E-01 M86376.1 NT Rat trop lastin gene, exon 28-36 3177 8326 13439 2.0 1.20E-01 M86376.1 NT Rat tropoelastin gene, exon 28- 36 3192 8341 13455 260 1.2OE-01 AW370668.1 EST HUMAN QVI-BT0259-261099-021- d05 BT0259 Homo saplens cDNA 3219 8367 1.0 1.2011-01 U67600.1 NT Methanococcus jannaschil section 142 of 150 of the complete genome 3433 8575 0,8 1.20E-01 Z991 18.1 NT Bacillus subdils complete genome (section 15 of 2l): from 2795131 to 3013540 3477 8618 13730 1.1 1.2OE-01 X56882.1 NT Wheat mRNA for a group 3 late embryogenesis abundant protein (LEA) 3477 8618 13731 1.1 1.20E-01 X56882.1 NT Wheat mRNA for a group 3 late embrpgenesis abundant protein (LEA) 3554 8575 1.2 1.20E-01 Z991 18,1 NT Bacillus subblis complete genome (section 15 of 2l): from 2795131 to 3013540 4090 9216 14298 2.2 1.2OE-01 Z54255.1 NT P.clarkii mRNA, repeat region (11) 2MRT7) 4090 9216 14299 2.2 1.20E-01 Z54255.1 NT P.clarkii mRNA,, ree!at region (11) 2MRT7) 4745 9856 14948 7.1 1.20E-01 S65019.1 NT mudn [rats, Sprague-DavAcy, sulfur-dioxlde-treated tracheal epithelium, mRNA Partial, 390 ntl 4775 9885 14977 6.7 1.20E-01 Z32774.1 NT H.saplens gene for N-methyi-D- aspartate receptor R1 exons 6-21 4775 9885 14978 6.7 1.20E-01 Z32774.1 NT H.sapiens gene for N-methyl-D- aspartate receptor R1 exons 6-21 5012 10114 1.0 1.20E-01 P16466 SWISSPROT HEMOLYSIN PRECURSOR 5174 10268 15339 1.5 1.2OE-01 010441 SWISSPROT HYPOTHETICAL 52.4 KI) PROTEIN C12B10.08C.IN CHROMOSOME 1 5174 10268 15340 1.5 1.20E-01 Q10441 SWISSPROT HYPOTHETICAL 52.4 KI) PROTEIN C12B10.08C IN CHROMOSOME 1 5199 10290 2.5 1.20E-01 AW401836.1 EST HUMAN U[-I-IF-13K0-aah-d-01-0-ULM NII-IjivIGQ_36 Homo sapiens cDNA done IMAGE:3053617 5' 2 5715 10833 1.0 1.1OE-01 A1561003.1 EST HUMAN tnl8d08.xl NCI CGAP 13m25 Homo saplens cDNA done IMAGE:2167983 3' Page 35 of 196 Table 4

599 5757 10876 1.2 1.1OE-01 AA569006.1 EST-HUMAN nmO8gll.sl NCI WAP-CO10 Homo saplens cDNA done IMAGE:1059620 3'similar to gb:X06985 mal'HEME OXYGENASE 1 (HUMAN); 1069 6207 1.3 1.1OE-01 AL161560.2 NT Arabidopsis thaliana DNA chromosome 4, condg fragment No. 60 1143 7908 11431 1.4 1.1OE-01 AW972158.1 EST-HUMAN EST384142 MAGE resequences, MAGI- Homo sapiens cDNA 1229 6359 11522 0.6 1.1OE-01 D64004.1 NT Synechocystis sp. PCC6803 complete genome, 23127, 2868767-3002965 1821 6940 0.9 1.1OE-01 AF051 784.1 NT Xenopus laevis 14S cohesin SMC1 subunit mRNA, complete cds 2266 7372 0.8 1.1OE-01 6755215 NT Mus musculus pre T-wil andgen receptor alpha (Ptcra), mRNA 2492 7875 1.2 1.1OE-01 6978676 NT Rattus norvegicus Procollagen 11 alpha 1 (Cd2al), mRNA 2520 7616 1.2 1.1OE-01 AW821909.1 EST HUMAN RCO-ST0379-210100-032-g04 S10379 Horno saplens cIDNA 2825 7976 13078 1.8 1.1OE-01 S82418.1 NT Intedeukin-12 p35 subunit [mice, Genomic, 700 nt, segment 4 of 51 2997 8149 13249 0.8 1.1OE-01 F03265.1 EST.HUMAN HWI RF022 normalized infant brain cDNA Homo sapiens cDNA clone c-1 r(02 3' 3299 8445 1.4 1.1OE-01 6753231 NT Mus musculus calclum channel. voltage- dependent, T type, alpha 1 G subunit (Cacnal g), mRNA 3374 8517 13624 3.0 1.1012-01 BE393186.1 EST HUMAN 60130867J1 NIH_MW 44 Homo sapiens cDNA clone IMAGE:3627066 5' 3405 8547 13655 1.5 1.1OE-01 X62135.1 NT C.reinharddi nuclear gene on linkage group XIX 3534 8675 13778 0.9 1.1OE-01 Y07695.1 NT A.Immersus gene for transposase 3648 8787 13880 1.2 1.1OE-01 X52708.1 NT G.gallus gene encoding non- bistone chromosomal protein HIVIG-14b, exons 4 and 5 4021 9150 14230 1,3 1.1OE-01 AW819412.1 EST HUMAN MR3-ST0290-290100-025- g07 ST0290 Horno sapiens cIDNA 4021 9150 14231 1.3 1.1OE-01 AW819412.1 EST HUMAR MR3-ST0290-290100-02"07 ST0290 Homo sapiens cDNA 4027 9155 0.9 1.1OE-01 AF030001.1 NT Mus musculus major histocompatibility locus class Ill region:butyrophilin-like protein gene, partial cds; Notch4,P13X2, RAGE, lysophaddic add acyll transferase-alpha, paimitoyl-protein thioesterase 2 (PPT2), CREB-RP, and tenascin X (TNX) genes, comple> 4159 9285 7.9 1.1OE-01 AF157066.1 NT Drosophila melanogaster ki icht protein (kiar) mRNA, complete cds 4189 9315 14399 0.8 1.1OE-01 AW802056.1 EST HUMAN ILS-UM0070-020500-068- a08 UM0070 Homo sapiens cDNA 4341 9464 5.9 1.1OE-01 P14728 SWISSPROT HYPOTHETICAL 82 KI) AVIRULENCE PROTEIN IN AVR13S3 REGION 4466 9586 14682 0.9 1.1OE-01 AF064564.2 NT Fugu rubripes neurofibromatosis type 1 (NFI). A-kinase anchor protein (AKAP84), BAW 4539 9658 14746 2.0 1.1OE-01 S44957.1 NT protein (BAW), and WSBI protein (WSB1) genes, complete cds Tapa-1 =integral membrane protein TAPA-1 [mice, B cell lymphoma line 38C13, Genomic, 1973 nt, segment 1 of 7] 4725 9837 14929 1.3 1.1OE-01 Y07695.1 NT A.immersus gene for transposase 4819 9928 15019 1.3 1.1OE-01 D90908.1 NT Synechocystis sp. PCC6803 complete genome, 10127, 1188886-1311234 4979 10082 15152 1,1 1.1OE-01 Z83335.1 NT S.pneurnonlae dexB, capl[A,B,C, D,E,F,G,H,I,J,KI genes, dTDP-rhamnose biosynthesis genes and allA gene 1183 6316 1.4 1.OOE-01 062855 SWISSPROT DEOWRIBONUCLEASE 11 PRECURSOR (DNASE 11) (ACID DNASE) (LYSOSOMAL DNASE 11) 1251 6380 11539 0.6 1.OOE-01 A1985499.1 EST-HUMAN wsO8d01.xl NCI_WAP--- Kidl 1 Homo sapiens cDNA done IMAGE:2496577 Ysimilar to contains MER7.t3 MER7 repetitive element; 1336 6464 11632 1.0 1.OOE-01 AE001492.1 NT Hellcobacter pylorl, strain J99 section 53 of 132 of the complete genome 1370 6498 11664 1.0 1.OOE-01 AL161504.2 NT Arabidopsis thallana DNA chromosome 4, condg fragment No. 16 1909 7626 12215 0.9 1.OOE-01 AW862179.1 EST HUMAN MR1-CT0355-1180200-007g07 CT0355 Homo sapiens cDNA Page 36 of 196 Table 4

2439 7538 127451 1.0 1.0OE-01 AW451365.1 EST-HUMAN Ul-H-B13-alc-d07-0-01. sl NCLCGAPSubS Homo saplens cIDNA clone IMAGE:2736420 3' 3130 8279 13366 4.7 1.0OE-01 AA314107.1 EST-HUMAN EST185958 Colon carcinoma (HCC) cell line 11 Homo sapiens cDNA 5' end 3130 8279 13387 4.7 1.0OE-01 AA314107.1 EST HUMAN EST185958 Colon carcinoma (HCC) cell line 11 Homo sapiens cDNA Tend 3603 8742 13837 2.6 1.0OE-01 U76890.1 NT Human amelogenin (AMELX) gene on X chromosome, partial promoter region 4307 9430 14519 1.5 1.0OE-01 AE002265.2 NT Chlarnydoph Lla pneumonlae AR39, section 91 of 94 of the complete genome 4455 0575 1.2 1.0OE-01 A1792349.1 EST-HUMAN an32c04.y5 Gessler Wilms tumor Homo sapiens cDNA done IMAGE:1700358 5, 4613 9727 14821 1.3 1.0OE-01 U50450.1 NT Drosophila melanogaster tyrosine kinase p45 lsoform (fer) mRNA, complete ods 4838 9945 15034 2.1 1.0OE-01 AW952344.1 EST-HUMAN EST364414 MAGE resequences, MAGB Horno sapiens cDNA 4983 10086 15156 6.0 1.0012-01 U50133.11 NT Human ankydn (ANKI) gene, exon 42 and complete ods 4983 10086 15157 6,0 1.OOE-01, U50133.11 NT Human ankyrin (ANK1) gene, exon 42 and complete cds 5149 10244 0.8 1.0012-01 BE157114.1 EST-HUMAN RC3-HT0371-180200-01 M1 HT0371 Homo saplens cDNA 5158 10253 15324 0.9 11.0OE-01 D49683.1 NT Mouse FTZ-FI gene 213 5456 1.6 9.9OE-02 AF136389.1 NT BacJlius cereus strain H6 gyrase B subunit (gyrB) gene, partial ods 3229 8377 13484 1.2 9.9OE-02 AF099810.1 NT Homo sapiens neureyJn Ill- alpha gene, partial cds 551 5714 0.5 9.8OE-02 X56338.1 NT 0.safiva RAmy3C gene; alpha-amylase 1711 6834 12014 0.6 9.8OE-02 4503224 NT Homo sapiens cytochrome P450, subfamily I1F, polypeptide 1 (CYP2F11) mRNA 3106 8256 13359 3.3 9.8OE-02 AF184274.1 NT Daucus carotaleucoanthocyanidin dioxygenase 2 (LDOX) mRNA, LDOX-2 alleie, complete cds.

4131 9257 14337 6.7 9.8OE-02 AF257329.1 NT Leptosphaeria maculans betatubulln mRNA, complete cds 4131 9257 14338 6.7 9.8OE-02 AF257329.1 NT Leptosphaeria maculans beta- tubulln mRNA, complete ods 1328 6457 11624 1.2 9.7OE-02 ABOO5808.1 NT Aloe arborescens mRNA for NADP- malic enzyme, complete cds 1567 6693 1.0 9.7OE-02 4503710 NT Homo sapiens fibroblast growth bctor rbceptor 3 (achondroplasia, thanatophoric dwarfism) (FGFR3) mRNA 2214 7322 12536 0.9 9.7OE-02 BE168660.1 EST HUMAN OV1-HT0516-070300-095- a04 HT0516 Homo sapiens cDNA 3901 9036 3.6 9.70E-02 Q99795 SWISSPROT CELL SURFACE A33 ANTIGEN PRECURSOR (GLYCOPROTEIN A33) 1969 7084 12285 1.3 9.6OE-02 A1080721.1 EST-HUMAN oz47dl 1.xl Soarep_Nhtk_SI Homo sapiens cDNA done IMAGE:1678485 3' 1969 7084 12286 1.3 9.6OE-02 A1080721.1 EST HUMAN oz47dl 1.xl Soares NhHMPu S1 Homo saplens cDNA done IMAGE:1678485 3' 2250 7356 12563 1.0 9.60E-02 AW836565.1 EST-HUMAN PM3-LT0032-030100-004- b01 LT0032 Homo saplens cDNA 2250 7356 12564 1.0 9.60E-02 AW836565.1 EST_HU PM3-LTOO3id301 W-004-b01 LT0032 Homo saplens cDNA 4248 9373 14453 6.0 9.6OE-02 Z32686.2 NT Proteus rnirablits firnbrial operon, strain H14320 4932 10038 15111 0.9 9.6OE-02 AW966230,1 EST-HUMAN EST378303 MAGE resequences, MAGI Horno sapiens cDNA 5093 10191 15270 0,8 9.60E-02 BE061729.1 EST-HUMAN RC5-ST0254-031 099-01 1-a03 BT0254 Homo sapiens dDNA 4012 9143 14226 2.3 9.5OE-02 AW992395.1 EST-HUMAN CM2-BN0023-050200-087- f12 BN0023 Horno sapiens cDNA 5062 10160 15236 0.9 9.5OE-02 U63374.1 NT Lycopersicon esculentum polygalacturonase Isoenzyme 1 beta subuffit gene, complete cds 1820 6939 12129 0.9 9.4OE-02 U55944.11 NT Cavia porcellus 3beta- hydrq"terold suifotransferase mRNA, complete cds 1820 6939' 12130 0.9 9.40E-02 U55944.1 NT Cavia porcellus 3betahydroxysterold sulfbtransferase mRNA, complete cds 3804 894L1. 14036 4.3 9.40E-02 Z33059.1 NT M.capdoolum DNA for CONTIG MC073 4980 10083 15153 0.9 9.40E-02 6753517 NT Mus musculus coding region determinant-binding protein LCrdbp). mRNA 2960 8111 1.8 9.3OE-02 4809280 NT Homo sapiens BAII -associated protein 3 (BAIAP3) mRNA fC Page 37 of 196 Table 4

2993 81 Z5- 5.4 9.30E-02 6912525 NT Homo saplans nasopharyngeal epithelium specific protein 1 NESG1), mRNA 3051 8202 13303 2.4 9.30E-02 L7881 0.1 NT Homo sapiens ADPIATP carder protein (ANT-2) gene, complete cds 3226 8374 13482 1.2 9.30E-02 Y08582.11 NT F.rubdpes hsRMS gene, V 4060 9187 14270 3.5 9.3OE-02 BE391943.1 EST_HUMAN 601286082F1 NIH MGQ_44 Homo sapiens cIDNA clone IMAGE:3607653 5' 4060 9187 14271 3.5 9.30E-02 BE391943.1 EST-HUMAN 601286082F1 NIH_MGC 44 Homo sapiens cDNA done IMAGE:3607653 5' 228 5419 10540 1,5 9.20E-02 U60315.1 NT Molluscum contaglosum virus subtype 1, complete genome 228 5419 10541 1.5 9.20E-02 U60315.1 NT Molluscum contaglosum virus subtype 1, complete genome 228 5419 10542 1.5 9.20E-02 U60315.1 NT Molluscurn contagicsum virus subtype 1, complete genome 2180 7289 0,8 9.20E-02 R54156.1 EST---HUMAN y998f07.rl Soares Infant brain 1 NIB Homo saplens cDNA done 1 MAGE:41618 5, 3142 8291 13398 4.5 9.20E-02 Q28631 SWISSPROT:MAJOR EPIDIDYMIS-SPECIFIC PROTEIN E4 (EPIDIDYMAL PROTEIN BE-20) 3265 8412 13518 1,2 9.20E-02 AA534354.1 ESTHUMAN nf79e0I.si NCI C_Co3 Homo sapiens c NA done IMAGE:926136 3' 3537 8678 1.1 9.20E-02 6755215 NT Mus musculus pro T-cell andgen receptor alpha ( tcra), mRNA 4145 9271 1.3 9.20E-02 U92048.1 NT Human herpesvirus 1 strain KOS-63, latency-associated transcript, promoter region 4211 9335 1.0 9.20E-02 BE299722.1 EST-HUMAN 600944365F1 NIH MGC 17 Homo sapiens 2DNA clone IMAGE:2960176 5' 4538 9657 14745 1.9 9.2012-02 X96402.1 NT G.gallus Mia-CK gene 417 5206 10308 0.9 9.1GE-02 X77665.1 NT 0. cuniculus k12 keradn gener 2365 7467 12671 1.0 9.1OE-02 P78985 SWISSPROT 6-PHOSPHOFRUCTOKINASE (PHOSPHOFRUCTOKINASE) (PHOSPI-10HEX0KINASE) 3618 8757 1.1 9.1OE-02 AW372569.1 EST-HUMAN PM2-ST0349-161299-001402 BT0349 Homo sapiens cDNA 3959 10298 14175 1.1 9.1OE-02 P16415 SWISSPROT ZINC FINGER PROTEIN ZFP-36 3959 10296 14176 1.1 9,1 OE-02 P16415 SWISSPROT ZINC FINGER PROTEIN ZFP- 36 3989 9121 14205 1.6 9.1OE-02 P42526 SWISSPROT HISACTOPHILIN 2 (HISTIDINE- RICH ACTIN-BINDING PROTEIN 2) (HS 11) 4383 9505 14590 1.8_ 9.1OE-02 AL161554.2 NT Arabidopsis thallana DNA chromosome 4, con g 0 727 5881 11022 1.2 9.OOE-02 P15328 SWISSPROT FOLATE RECEPTOR ALPHA PRECURSOR (FR-ALPHA) (FOLATE RECEPTOR 1) (FOLATE RECEPTOR, ADULT) (ADULT FOLATE-BINDING PROTEIN) (FBP) (OVARIAN TUMOR-ASSOCIATED ANTIGEN MOV18) (KB CELLS F13P) 1617 6743 11911 2.3 9.OOE-02 BE220482.1 EST_HUMAN hv39g10.xl NCI_PGAP- LU24 Honno sapiens cDNA done IMAGE:3175842 Ysimilar to contains Alu repetitive element; 2772 7856 13060 1.1 9.OOE-02 AF138522.1 NT HIV-1 P8c095-06 from USA envelope glypoprotein (env) gene, partial Cels 2772 7856 13061 1.1 9.OOE-02 AF138522.1 NT HIV-1 p8c095-06 from USA envelope glyooproteln (env) gene. parfial cds 3294 8440 13550 0.9 9.OOE-02 AF279135.1 NT Dictyostellum discoldeum spore coat structural protein SP65 (cotE) gene, complete cds 4202 9327 14415 0.8 9.OOE-02 S68757.1 NT cordcosterold-binding globulin [Saimiri scJureus=squiffel monkeys, liver, mRNA, 1474 ntl 4202 9327 14416 0.8 9.OOE-02 S68757.1 NT corUcosterold-binding globulin [Salmid sdureus=squirrel monkeys, liver, mRNA, 1474 nt] 4321 14533 1.2 9.OOE-02 P55268 SWISSPROT LAMININ BETA-2 CHAIN PRECURSOR (S-LAMININ) 4568 9686 14780 1,8 9.OOE-02 X65740.2 NT Plasmodium faidparum P-type ATPase 3 gene 5142 10237 15312 1.1 9.OOE-02 Q24597 SWISSPROT REGULATORY PROTEIN ZESTE 5151 1014-6 15318 1.0 9.OOE-02 BE159422.1 EST HUMAN MRO-HT0407-140200-009- b04 HT0407 Homosaplens cDNA 2338 7440 12649 0.5 8.9OE-02 BE153572.1 EST HUMAN PMO-HT0339-251199-003d01 HT0339 Homo sapiens cIDNA 4534 9 0.9 8.90E-02 AA424887.1 EST-HUM N zw03d04.s1 Soares Nhi-IMPLLS1 Homo sapiens cIDNA done IMAGE:768199 3' 1351 6479 11645 1.3 8.8OE-02 Q27474 SWISSPROT PROBABLE DNA LIGASE (POLYDEOWRIBONUCILEOTIDE SYNTHASE [ATP]) Page 38 of 196 Table 4

3828 8965. 14064 1.0 8.8OE-02 AA299128.1 EST-HUMAN EST1 1595 Uterus Homo sapiens cDNA 5' end TRANSCRIPTION INITIATION FACTOR TFIll) 135 KDA SUBUNIT (TAF11-135) (TAF11135) 3948 9081 3.2 8.8OE-02 000268 SWISSPROT (TAF11-130) (TAF11130) 4205 9330 1,1 8.8OE-02 4580423 NT Homo sapiens paired box gene 6 (aniridia, keratitis) (PAX6), Isoform b, mRNA Homo sapiens zinc finger protein 92 (WP92), expressed-Xq28STS protein (XQ28ORF), and biglycan (BGN) genes, complete ods; and plasma membrane calcium ATPase Isoform 3 3636 8775 13869 3.0 8.70E-02 U82695.2 NT (PMCA3) gene, partial cds Homo saplens zinc finger protein 92 (ZFP92), expressed-Xq28STS protein (XQ28ORF), and biglycan (BGN) genes, complete cds; and plasma membrane calcium ATPase isoform 3 3636 8775 13870 3.0 8.70E-02 U82695.2 NT (PMCA3) gene, partial eds zh68a02xl Soares_fetal - live_spleen_l NFI-S-S1 Horno sapiens cDNA done 3879 9015 14110 0.8 8.70E-02 W87841.1 EST-HUMAN IMAGE:417194 W similatto contains element MER12 repetitive element; 4609 9723 14818 1.2-8.70E-02 AF178636.1 NT Mus musculus JNK interacting protein-3a (J1p3) mRNA, complete cds Methanobactedum thennoautotrophicum from bases 1176181 to 1189406 (section 101 of 5034 10134 1.1 8.70E-02 AE000895.1 NT 148) of the complete genome 1232 6361 11523 2.4 8.60E-02 AJ271736.1 NT Horno sapiens Xq pseudoautosomal region; segment 212 2197 7306 12518 0.8 8.60E-02 BE408667.1 EST-HUMAN 601304016F1 NIH MGC 21 Homo sapieno cDNA done IMAGE:3638643 5' 3151 8300 13408 2.9 8.60E-02 L05468.1 NT Trichomonas vaginalls beta- tubulin (bWbl) gene, complete ods Dictyostellum discoldeum iplA gene for Inositol 11,4,5-hisphosphate receptor-like protein 3264 8411 0.8 8.6OE-02 AJ277590.1 NT (1p1A), exons 1-4 3593 8732 3.1 8.6OE-02 AF153362.1 NT Dictyostelium discoldeum adenylyl ffdase (acrA) gene, complete ods 4385 95577 14592 0.9 8.60E-02 U68179.1 NT Orydolagus cuniculus gale n-3 gene, untranslated exon and 5'flanking region 1330 W9 11625 0.6 8.5OE-02 AB007855.1 NT Homo saplens KIAA0395 mRNA, partial ods 2347 7449 12656 1.0 8.5OE-02 AE000652.1 NT Helicobacter pylod 26695!ecdon 130 of 134 of the wmplete'genome zd44el 1xl Soarek_fetal-hearLNbHH19W Horno sapiens cDNA clone IMAGE:343532 5' 2632 7950 12923 1.5 8.40E-02 W69330.1 EST HUMAN oeOgbOg.sl NCI_PGAP_Ov2 Homo sapiens eDNA done IMAGE:1385369 similar to contains 4152 9278 0.8 8.40E-02 AA847045.1 EST HUMAN Alu repetitive element; contains element L1 repetitive element; 1965 7081 12280 0.9 8.30E-02 5835680 NT Ixodes; hexagonus mitochonddon, complete genorn. c 1965 7081 12281 0.9 8.3OE-02 5835680 NT Ixodes hexagonus mitochonddon, complete genome 3544 8685 13786 6.2 8.3OE-02 P75334 SWISSPROT HYPOTHETICAL LIPOPROTEIN MG309 HOMOLOG PRECURSOR 3567 8706 13803 0.9 8.30E-02 A1436797.1 EST-HUMAN M2g06.xl Soares Nhi- IMPu S1 Honno saplens cDNA done IMAGE:2125210 3 3567 8706 13804 0.9 8.30E-02 A1436797.1 EST HUMAN th8206.xl SoareLNWIVIPu_SI Horno sapiens eDNA done IMAGE:2125210 3' 1243 6372 0.7 8.20E.02 6681050 NT Mus musculus colony stimulating factor 3 receptor (granulocyte) (Csf3r), mRNA 1357 6485 2.8 8.20E-02 Y08170.2 NT Gallus gallus mIRNA for for OBCAM protein gamma Isoform 1480 6607 11780 1.2 8.20E-02 AF167077.2 NT Canis famillads glutamate, transporter (EAAT4) mRNA, complete ods 3036 8188 1.8 8.2012-02 AL163206.2 NT Homo saplens chromosome 21 segment HS21C006 3733 8870 1.3 8.20E-02 ALI 61498.2 NT Arabidopsis thallana DNA chromosome 4, condg fragment No. 10 3926 9060 14147 1.1 8.20E-02 AL163206.2 NT Horno sapiens chromosome 21 segment HS21 C006 4187 9313 14394 5.4 8.2012-02 P48960 SWISSPROT LEUCOCYTE ANTIGEN CD97 PRECURSOR 4187 9313 14395 5.4 8.20E-02 P48960 SWISSPROT LEUCOCYTE ANTIGEN CD97 PRECURSOR Page 39 of 196 Table 4

4187 9313 14396 5.4 8.20E-02 P48960 SWISSPROT LEUCOCYTE ANTIGEN CD97 PRECURSOR 5014 10116 15187 2.8 8.20E-02 U76009.11 NT Mus musculus Anc transporter (ZnT-3) gene, complete cds 1479 6606 11779 1.7 8.1OE-02 AB017138.1 NT Pseudomonas pudda malonate decarboxylase gene duster (mdcA, mdcB, mdcC, mdcD, mdcE, mdcG, mdcH, mdcL and mdcM genes), complete cds 7879 10316 1.1 8.OOE-02 AW954653.1 EST HUMAN EST366723 QA-GE resequences, MAGC Homo sapiens cIDNA 920 6066 11222 1.3 8.OOE-02 U60315.1 NT Molluscum contaglosum virus subtype 1, complete genome 1353 6481 11647 4.6 8.OOE-02 D63861.1 NT Homo sapiens DNA for cydophilin 40, complete ods 1671 7923 11972 3.8 8.00IE-02 D26535.1 NT Human gene for dihydrolipoamide sucdnyitransferase, complete cds (exon 1-15) 1671 7923 11973 3.8 8.OOE-02 D26535.11 NT Human gene for dihydrolipoamide succinyltransferase, complete cds (exon 1-15) 1861 6979 12164 1.4 8.OOE-02 BE067219.1 EST HUMAN PM3-BT0347-170200-001- b08 BT0347 Homo sapiens cDNA 2323 7426 12635 1.0 8.OOE-02 D90915.1 NT Synechocysfis sp. PCC6803 complete genome, 17127, 2137259-2267259 2323 7426 12636 1.0 8.OOE-02 D90915.1 NT Synechocystis sp. PCC6803 complete genome, 17127, 2137259-2267259 2790 6213 11365 0.8 8.OOE-02 M23449.1 NT Dictyoselium discoldeum cyclic nudeofide phosphodiesterase gene, complete cds 3745 8883 13972 0.8 8.OOE-02 AW966118.1 EST HUMAN EST378191 MAGE resequences, MAGI Homo sapiens cIDNA 3980 9112 1.1 8.OOE-02 4503034 NT Homo sapiens cAMP responsive element binding protein-like 2 (CREBL2) mRNA 4709 9821 5.6 8.OOE-02 X72794.11 NT M.musculus gene for gelatinase B 4834 9942 15031 0.9 8.OOE-02 M28071.1 NT Herpesvirus salmid transformation-associated protein (STP), and dihydrofolate reductase (DHFR) gene,s complete cds, and small nuclear RNAs (uRNAs) 1544 6671 11841 0.5 7.9OE-02 AE001501.1 NT Helicobacter pylori, strain J99 section 62 of 132 of the complete genome 1544 6671 11842 0.5 7.9OE-02 AE001501.1 NT Hellcobacter pylod, strain J99 section 62 of 132 of the complete genome 2127 7237 12445 1.4 7.9OE-02 BE250008.11 EST-HUMAN 600943191 Fl N1H MGC 15 Homo sapiens d3NA done IMAGE:2959510 & 2948 8099 13205 6.4 7.9OE-02 A1582029.1 EST HUMAN ar98c08.xl Barstead colon HIPLIRB7 Homo sapiens cIDNA done IMAGE:2173646 3' similar to g15226876 60S RIBOSOMAL PROTEIN L38 (HUMAN); 3255 8402 13508 1.2 7.9OE-02 A1457925.1 EST HUMAN q55g03.xl Soares_NSFF_9VV_0'_PkP_Sl Homo sapiens cIDNA clone IMAGE:2145460 3' 3776 8913 14003 3.3 7.90E-02 6681044 NT. Mus musculus colony stimulating factor 1 receptor (Csfl r), mRNA 3776 8913 14004 3.3 7.9OE-02 6681044 NT Mus musculus colony stimulating factor 1 receptor (Csflr), mRNA 4706 9818 1.2 7.9OE-02 ABOO801 9.1 NT' Arabidopsis thallana RXW24L mIRNA, partial cds 1192 6324 11479 1.4 7.8OE-02 A1793275.1 EST-HUMAN oo59d02.yS NCI - CPAP_Lu5 Homo sapiens cIDNA clone IMAGE:1 570467 5, similar to contains Ll.t3 Ll repetitive element; 1192 6324 11480 1.4 7.8OE-02 A1793275.1 EST-HUMAN oo59d02.y5 NCI-CLu5 Homo sapiens cIDNA done IMAGE: 1570467 Csimilar to contains Ll.t3 Ll repetitive element; 1378 7915 11671 1.0 7.8OE-02 AW866884.1 EST-HUMAN CM3-SN0032-010400- 137407 SNO032 Homo sapiens cIDNA 5019 8828 2.7 7.8OE-02 BE250048,1 EST HUMAN 600943055F1 N1H MGC 15 Homo sapiens cIDNA clone IMAGE:2959693 5' 5197 10288 15357 1.0 7.8OE-02 A1418520.1 EST HUMAN tg48g12.xl Soares-NIFL- T-GI3C-SI1 Homo sapiens cIDNA done IMAGE:2112070 3' similar to contains MER110.1:3 MER10 repetitive element; 3538 8679 2.1 7.7OE-02 AJ238093.1 NT Homo sapiens pardgi AF-4 gene, exons 2 to 7 and Alu repeat elements 3362 8505 13613 0.9 7.6OE-02 AA296447.1 EST HUMAN EST1 12214 Cerebellum 11 Horno sapiens cIDNA C end similar to similar to protocadherin 43 35121 8653 13761 0.9 7.6OE-02 AJ400877.1 NT Homo saplens ASCL3 gene, CEGP1 gene, Cl lorf14 gene, Cl lorl15 gene, Cl lorl16 gene and Cl 1 orfl 7 gene Page 40 of 196 Table 4

4765 9876 1.0 7.6OE-02 AW858844.1 EST HUMAN RC3-CTO347-110300-014-a05 CTO. 347 Horno sapiens cIDNA 6 (neurotransmitter transporter, glydne), member 9 Homo sapiens solute carder family 767 5920 11067 1.1 7.5OE-02 5902093 NT (SI-C6A9), mRNA Homo sapiens solute carder family 6 (neurotransmitter transporter, glycJne), member 9 767 5920 11068 1.1 7.5OE-02 5902093 NT (SLC6A9), mRNA 1878 6996 12181 0.9 7.5OE-02 AL163278.2---NT Horno sapiens chromosome 21 segment HS21 C078 Intedeukin-18, Intron. 1 and exon 2 4407 9527 14617 0.8 7.5OE-02 A8015961.1 NT Horno saplens IL-18 gene for LT0054 Homo saplens cIDNA 469 5634 10763 1.2 7.4OE-02 AW838547.1 EST HUMAN RC5-LT0054-2601 00-01 1- HO9 1444 6571 1.1 7.4OE-02 AF030027.1 NT Equine herpesvirus 4 strain NS80567, complete genome homeodornaln transcription factor 1 (PitKl), mRNA 2536 7632 13787 0.9 7.4OE-02 6755069 NT Mus musculus paired-like 3545 8686 0.9 7.4OE-02 A1807885.1 EST HUMAN wf43h01.xl Scares NFL T G13C_S1 Horno sapiens CUNA done IMAGE:2358385 T ADPIATP carrier protein (ANT-2) gene, complete cds 9720 1481 3.4 7.4OE-02 L7881 0.1 NT Homo sapiens 9799 14902 2.7 7.4OE-02 6978442 NT Rattus norvegicus Activin receptor like kinase 1 (Acvdl), m-RNA c-terminal hydrolase related polypeptide (Uchrp), mRNA 4858 9965 15050 1.7 7.4OE-02 6678492 NT Mus musculus ubiquindn 669 5825 10952 0.9 7.3OE-02 AE001789.1 NT Thermotoaa maddma section 101 of 136 of the complete genome 1465 7917 11769 1.1 7.3OE-02 AW900281.1 EST HUMAN CMO-NN1004-130300-28"08 NN1004 Horno saplens cL)NA 1801 7927 5.4 7.3OE-02 AL163302.2 NT Horno saplens chromosome 21 segment HS21C102 factor USF2 (USF2) gene, exons 8-10 and complete ods 4927 10034 1.0 7.3OE-02 U12283.1 NT Mus musculus transcription thermoautotrophicum trom bases 1029155 to 1039934 (section 88 of 148) Methanobacterium 114 5315 10443 0.9 7.2OE-02 AE000882.1 NT of the complete genome from bases 1029155 to 1039934 (section 88 of 148) Methanobactedum thermoautotrophicum 114 5315 10444 0.9 7.2OE-02 AE000882.11 NT of the complete genome 1460 6587 11760 -0.8 7.2OE-02 AL163301.2 NT Homo saplens chromosome 21 segment HS21C101 1460 65F7 11761 0.8 7.2OE-02 AL163301.2 NT Horno saplens chromosome 21 segment HS21 Cl 01 1 Isolate 26 reverse tranwiptase (pol) gene, Internal virus Human Immunodeficiency type 2502 7599 14043 0.9 7.2OE-02 U14794.1 NT fragment, partial ods 1.11 3810 8947 15168 0.8 7.2OE-02 AW298322.1 EST HUMAN Ul-H-BWO-aji-a-05- 0-Ul.sl NCI_PGAP-SuW Homo sapiens cDNA clone IMAGE:2732049 3, 4997 10100 11380 0.9 7.2OE-02 A13001562.1 NT Streptococcus mutans gene for glucose-1 -phosphate uridylyltransferase, complete cds 1091 6229 1.3 7.11OE-02 A13010711.1 NT Mus sp. mRNA for MB20, complete cds virus 1 (D9) proviral structural capsid protein (gag) gene, Human Immunodeficiency type 1862 5681 12165 0.6 7.1OE-02 L02290.1 NT partial cds 517 6611 10802 1.2 7.OOE-02 Q07092 SWISSPROT COLLAGEN ALPHA 1(XVI) CHAIN PRECURSOR 1484 0.5 7.OOE-02 X96677.1 NT M.arUellia Mtcut-1 gene colon ffi37204) Horno saplens cIDNA done IMAGE:509599 3' 1725 6848 12027 1.4 7.OOE-02 AA056343.1 EST-HUMAN A66f04.sl Stratagene 2994 8146 13247 7 7.OOE-02 AW138152.1 EST_HUMAN Ul-H-Bil-acy-c-07-0-Ul.sl NCI-CGAF_Sub3 Horno sapiens cDNA done IMAGE:2716020 3, 1 SoaresLtestis_NHT Homo saplens cIDNA done 1375678 Ysimilar to gb:K03002 a165a12.sli 959 14055 1.0 7.OOE-02 AA815438.1 EST HUMAN 60S RIBOSOMAL PROTEIN L32 (HUMAN); 88959 091 14174 1 OOE-02 BE070264.1 ul 'MAN QTO407-2801 00-090-el 0 _BT0407 Homo saplens cDNA 99091 Page 41 of 196 Table 4

4047 9174- 1,1 7.OOE-02 AW792962.1 EST HUMAN CM0-UM0001-060300-270-e12 UM0001 Homo sapiens cIDNA 4121 9247 14331 1,3 7.OOE-02 AF0778211.1 NT Canis famillaris inducible nitric oxide synthase mRNA, complete cds 503 5667 10788 1.8 6.9OE-02 AIL163210.2 NT Homo sapiens chromosome 21 segment HS21C010 503 5667 10789 1.8 6.9OE-02 AL163210.2 NT Homo, sapiens chromosome 21 segment HS21 Col 0 Homo sapiens regulator of Gz-selecdve protein signalIng (ZGAP1) mRNA, and translated 1311 6439, 1.3 6.90E-02 4507968 NT products 3724 8861 13953 1.4 6.9OE-02 Q06364 SWISSPROT 26S PROTEASOME REGULATORY SUBUNIT S3 (NUCLEAR ANTIGEN 21 D7) 3724 8861 13954 1.4 6.9OE-02 006364 SWISSPROT 26S PROTEASOME REGULATORY SUBUNIT S3 (NUCLEAR ANTIGEN 21 D7) 5100 10196 1.1 6.9OE-02 AF079906.1 NT Rabies virus Isolate b615 glycoprotein gene, partial ods ae30f02.rl Gessler Wilms tumor Homo sapiens cDNA done IMAGE:897339 5' similar to 1839 6958 12142 1.1 6.8OE-02 AA496759.1 EST HUMAN gb:M22382 MITOCHONDRIAL MATRIX PROTEIN P1 PRECURSOR (HUMAN); ae30f02.rl Gessler Wilms tumor Homo sapiens cDNA done IMAGE:897339 5'similar to 1839 6958 12143 1.1 6.8OE-02 AA496759.1 EST HUMAN gb:M22382 MITOCHONDRIAL MATRIX PROTEIN P1 PRECURSOR (HUMAN); 1865 6983 12167 1.4 6.8OE-02 AF156673.1 NT Homo sapiens putative hepatic transcripfi n factor (W13SCR14) gene, complete cds 3062 8213 13312 1.2 6.8OE-02 AA781996.1 EST HUMAN a175a06.si Soares_testis---NI-IT Homo, sapiens cIDNA done 1376626 3' 3062 8213 13313 1.2 6.8OE-02 AA781996.1 EST HUMAN a175a06.sl Soares_tesdr, _NHT Horno, sapiens cIDNA done 1376626 3' 3062 8213 13314 1.2 6.8OE-02 AA781996.1 EST HUMAN ai75a06.sl Soares testis_NHT Homo sapiens cIDNA clone 1376626 3' 4453 9573 0.9 6.80E-02 BE141076.1 EST-HUMAN MRO-HT0069-071099-001-c05 HT0069 Homo sapiens cDNA' 4773 9883 14976 0.9 6.8OE-02 M96150.1 NT Caenorhabdifis elegans LDL raceptor-rela d protein (Irp-1) gene, complete cds Oncorhynchus mykiss TAP1 protein (OnmyTAP1) mRNA, OrimyTAP101 allele, complete 1511 6638 1 0.8 6.70E-02 AF115536.1 NT cds 1851 6969 12154 0.9 6.70E-02 A1220285.1 EST HUMAN qg79e04.xl Soares_W BC S1 Homo sapiens cIDNA done IMAGE:1 841406 X 2962 8113 13219 1.1 6.7012-02 M13158.1 NT Yeast (S.pombe) odc25+ gene (mitosis Initiation), complete ods 2962 8113 13220 1.1 6.70E-02 M13158.1 NT Yeast (S.pombe) cdc25+ gene (mitosis Initiation), complete cds xr85h01.xl NCI - WAP - Lu26 Horno saplens cDNA done IMAGE:2766961 Ysimilar to 3316 8461, 13573 0.8 6.7OE-02 AW301973.1 EST - HUMAN contains element TARI repetitive element; 3656 87951 13888 3.5 6.7OE-02 P17278 SWISSPROT HOMEOBOX PROTEIN HOX-134 (CHOX-A) at12e09.xl Barstead aorta HPI-RI36 Homo sapiens cIDNA done IMAGE:2354920 Ysimilar to 1326 64551 11621 1.1 6.6OE-02 A1735509.1 EST-HUMAN SW:LIN1 NYWO P08548 LINE-1 REVERSE TRANSCRIPTASE HOMOLOG.

1347 64751 11641 0.5 6.6OE-02 AF245116.1 - NT Drosophila melanogaster cactin mRNA, complete ods 3133 82821 1,3 6.6OE-02 Q13585 SWISSPROT MELATONIN-RELATED RECEPTOR (H9) 3418 8560 13671 8.6 6.6OE-02 R64306.1 EST-HUMAN A18b10.sl Soares placenta N152HP Homo sapiens cIDNA done IMAGE:139579 31 3432 8574 13686 2,2 6.6OE-02 7108357 NT Horno saplens mesothelin (MSLN), transcript variant 1, mRNA 3432 8574 13687 2.2 6.6OE-02 7108357 NT Horno saXns mesothenn (MSLN), transcript variant 1, mRNA INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2 PRECURSOR (ITI HEAVY CHAIN 4904 10011 15090 8.4 6.6OE-02- 061703 SWISSPROT H2) INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2 PRECURSOR (IT1 HEAVY CHAIN 4904 10011. 15091 8.4 6.6OE-02 Q61703 SWISSPROT H2) 5167 102611 15332 1.3 6.60E-02 AF204882.1 NT Amsacta albistriga nu polyhedrovirus AcORF17 homolog gene, complete cds 971 61171 11275 0.6 6.5OE-02. 7706068 NT Horno sapiens E2F-like protein (LOC51270), mRNA 13 6 9 a-9-71 1-16631 1,5 6.5OE-02 U47624,1 INT 1Xenopus laevis alpha Ecatenin mRNA, com lete ods Page 42 of 196 Table 4

Page 43 of 196 1702 6825 12006 0.8 6.50E-02 AE000764.1 NT Aquifex aeolicus section 96 of 109 of the complete genome 561 5723- 10839 0.5 6.40E-02 X94549.1 NT A.carterae precursor of peddinin- chlorophAla-protoin (PCP) gene 4802 8133 13240 1.4 6.40E-02 6996923 NT Mus musculus histone deacetylase 5 (Hdac5), mRNA 5180 10272 8.8 6.40E-02 6996923 NT Mus musculus histone deacetylase 5 (Hdac5), mRNA locus class Ill regions Hsc70t gene, partial cds; Mus musculus major histocompatibility cds:

smRNP, G7A, NG23, MutS homolog, CI-CP, NG24, NG25, and NG26 genes, complete 1720 6843 12022 0.9 6.30E-02 AF109905.1 NT and unknown genes 3552 8692 14363 2.1 6.3OE-02 P37092 SWISSPROT HEAT SHOCK PROTEIN 70 HOMOLOG.

4157 9283 3.4 6.2OE-02 AL1 61572.2 NT Arabidopsis thaliana DNA chromosome 4, condg fragment No. 68 Rattus norvegicus differentaflon-assodated Na-dependent Inorganic phosphate cotransporter 4243 9368 1.1 6.20E-02 AF271235.1 NT (DNPI) mRNA, complete cds MAGA Honno sapiens cDNA 4347 9470 14559 0.8 6.20E-02 AW951243.1 EST HUMAN EST363313 MAGE resequences, MAGA Horno saplens cDNA 4347 9470 14560 0.8 6.20E-02 951243.1 EST HUMAN EST363313 MAGE resequences, 52 KID RO PROTEIN (SJOGREN SYNDROME TYPE A ANTIGEN (SS-A)) (RO(SS-A)) 4479 9599 5.4 6.2OE-02 Q62191 SWISSPROT (R052) 256 5444 10570 1.5 6.1OE-02 D16471.1 NT Human mRNA, Xq terminal portion thaliana K+ Inward rectifying channel protein (AtKC1) gene, complete cds 3909 9044 15317 2.7 6.1 OE-02 U73 NT Arabidopsis 5150 10245 1.0 6.1OE-02 325.1 NT Homo saplens mRNA for KIAA1464 protein, partial cds 1 A13040897.1 maddma section 89 of 136 of the complete genome 1241 6370 11529 1.4 6.OOE-02 AE001777.1 NT Thermotoga MR3-ST0220-120100-02"04 ST0220 Homo sapiens cDNA 2547 7643 1.5 6.n0E-02 AW8161 19.1 EST HUMAN MAGE MAW Homo sapiens cDNA' 2641 7730 __12931 0.6 6.OOE-02 AW968548.1 EST_HUMAN EST380924 resequences, cord mitochondrial DNA, NADH dehydrogenase subunit 4, tRNA-Gin, tRNA- Mescicestoldes 2745 7829 0.6 6.OOE-02 AB031289.1 NT Phe, tRNA-Met, ATPase subunit 6, and NADH dehydrogenase subunit 2 2906 5298 10424 1.2 6.OOE-02 AA188730.1 EST HUMAN zp78c04xl Stratagene HeLa cell s3 937216 Homo saplens cDNA done IMAGE:626310 5' 2906 5298 10425 1.2 6.OOE-02 AA188730.1 EST HUMAN zp78c04xl Stratagene HeLa cell s3 937216 Homo, sapiens cDNA clone IMAGE:626310 6 adenocardnoma IV Homo sapiens cDNA V end similar to tissue-specific EST84265 Colon 3191 8340 13453 1.2 6.OOE-02 AA372376.1 ESTHUMAN protein adenocardnoma IV Homo sapiens cDNA Vend similar to fissue-specific EST84266 Colon 3191 8340 13454 1.2 6.OOE-02 AA372376.1 EST HUMAN protein 4893 10000 15083 1.2 6.OOE-02 Z67739.2 NT Streptococcus pneumonlae parC, parE and transposase genes and ORF DNA RCI-DT0001-290100-012-e10 DT0001 Homo sapiens cDNA 229 5420 10543 1.2 5.9OE-02 AW934719.1 EST HUMAN 2955 8106 13213 2.6 5.9OE-02 AF190269.1 NT Mus musculus p53 tumor suppressor gene, exon 10 and 11, partial cds; alternatively spliced 4517 9636 1.1 5.9OE-02 4506466 NT Homo saplens radiyJn (RDX) mRNA_ cerevislae protein tyrosine phosphatase (PTP3) gene, complete cds 4770 9881 14975 0.9 5.9OE-02 AF006304.1 NT Saccharom s 917 6063 1.5 5.8OE-02 D90110.1 NT Thiobacillus ferrowddans merC, merA genes and URF-1 2830 7981 1.1 5.8OE-02 AJ223521.1 NI ocarpa CCoAOMT.1 gene, exon 1 to exon 5 maritima section 87 of 136 of the complete genome 3613 8752 13846 1.4 5.8OE-02 AE001775.1 NT Thermotoga NCI CGAP_Kidl 1 Homo saplens cDNA done IMAGE:2544578 3' 4257 9382 14463 4.4 5.8OE-02 AW051927.1 EST HUMAN wx24c02.xl Table 4

4257 9382 14464 4.4 5.8OE-02 AW051927.1 EST-HUMAN wx24c02.xl NCI_CW Kidl 1 Homo sapiens cIDNA done IMAGE:2544578 3' 4447 9567 14664 4.2 5.8OE-02 A1247505.1 EST-HUMAN qh56f01.xl Soares - fetal - liver - spleen - 1 NFI-S-S1 Homo sapiens cDNA clone IMAGE:1848697 3'sImilar to qb:M13142 COAGULATION FACTOR Xl PRECURSOR (HUMAN); 4447 9567 14665 4.2 5.8OE-02 A1247505.1 EST-HUMAN qh56f01.xl Soares--- fetal - liver - spleen 1INIFI-S - S1 Homo sapiens cDNA clone IMAGE:1848697 3 similar to gb:M13142 COAGULATION FACTOR XI PRECURSOR (HUMANk 4471 9591 2.0 5.8012-02 AF096264.11 NT Gallus gallus tyrosine kinase JAK1 (JAK1) mRNA, complete cds 2659 7748 12946 1.0 5.7OE-02 A1708246.1 EST-HUMAN as2006.xl Barstead aorta HPI-RB6 Homo sapiens cDNA clone IMAGE:2318147 Ysimilar to gb:X14850-cdsl HISTONE H2A.X (HUMAN); 2659 7748 12947 1.0 5.7OE-02 A1708246.1 EST HUMAN as2006.xl Barstead aorta HPI-RI36 Homo sapiens cDNA clone IMAGE:2318147 Ysimilar to gb:X14850 cdsl HISTONE H2A.X (HUMAN); 3018 8170 13270 1.3 5.7OE-02 A1081644.1 EST HUMAN ou63b05.sl NCI - CGAP - W Homo sapiens c[DNA clone IMAGE: 1632465 Ysimilar to WP:C37A2.2 CE08611 1, 3033 8185 13286 1.3 5.70E-02 AF119117.1 NT Homo sapiens dopamine transporter (SLC6A3) gene, complete cds 3731 8868 13960 1.8 5.7OE-02 AW966791.1 EST-HUMAN EST378865 MAGE reseque2ces, MAGI Horno sapiens cDNA 1510 6637 11806 0.9 5.6OE-02 AF094455.1 NT Hydrocotyle rotundifolia dbosomal protein L1 6 (rpil 6) gene, intron; chforoplast gene for chloroplast product 4217 9341 14425 0.9 5.60E-02 AJ390487.1 NT Candida albicans mitochonddal mRNA for NADH dehydrogenase (ndel gene) 4540 9659 14747 1.3 5.6OE-02 AB013100.1 NT Lycopersicon esculentum LE- ACS6 mRNA for 1 -aminocydopropane-1 -carboxylate synthase, complete cds 4598 9712 14804 1.1 5.6012-02 AA290599.1 EST HUMAN zs45c01.sl NCI_WAP_GM11 Homo sapiens cDNA clone IMAGE:700416 3' 2618 7708 12907 3.0 5.50E-02 X97869.1 NT H.sapiens gene encoding La autoantigen 3179 8328 13441 3.6 5.50E-02 6755501 NT Mus musculus SH3 domain protein I B (Sh3M B), mRNA 4777 9887 14980 0,8 5.5OE-02 AF161266.11 NT Murray Valley encephalitis virus strain MVE-1-51, complete genome 2986 8138 1.0 5.40E-02 AJ277468.1 NT Oryza sativa rbbi3-1 gene for putative Bowman Birk trypsin Inhibitor 3375 8518 6.3 5.40E-02 BE073468.1 EST-HUMAN RCS-BT0559-140200-012-CO3 BT0559 Homo sapiens cDNA 4908 10015 15095 0.9 5.40E-02 U53528.1 NT Xenopus laevis homeobox protein (Vox-1) mRNA, complete cds 5108 10204 15283 1.0 5.40E-02 M96761.1 NT Mus rnuscuius p-glycoprotein (mdria) gene, exons 1 and 2 1037 6177 11329 0.6 5.30E-02 AW391248.1 EST HUMAN QVO-ST0213-021299-062- a09 ST0213 Horno sapiens cDNA 1037 6177 11330 0.6 5.30E-02 AW391248.1 EST HUMAN OVO-ST0213-021299-062- a09 ST0213 Horno sapiens cDNA 1489 6616 11787 6.6 5.3OE-02 T94759.1 EST HUMAN ye37f12xl Stratagene lung (#937210) Homo sapiens cDNA clone IMAGE:1 19951 Csimilar to gb:K01506 HLA CLASS 11 HISTOCOMPATIBILITY ANTIGEN, DP(1) ALPHA CHAIN (HUMAN); 2447 7546 12754 1.1 5.3OE-02 AJ276408.1 NT Pseudomonas pubda ttgS gene 2912 8063 13170 3.9 5.3012-02 M58417.1 NT Drosophila melanogaster laminin B2 gene, complete cds 2912 8063 13171 3.9 5.30E-02 M58417.1 NT Drosophila melanogaster laminin B2 gene, complete cds 3113 8262 13366 4.6 5.30E-02 A.1276408.1 NT Pseudomonas pudda ttgS gene 1.2 1 NT Arabidopsis thallana e115 gene, exons 1-11 5021 10122. 5.3OE-02 M80463.1 NT Mus musculus caudal type homeobox-1 (Cdx- 1) gene, complete cds 2239 7345 1519,1E17 A3 5.20E-02 1 5031908 NT Homo saplens mepdn A, alpha (PABA pepfide hydrolase) (MEMA) mRNA 160.0 Page 44 of 196 Table 4

4181 9307 14386 3.4 5.20E-02 U071132.1 NT Human steroid hormone receptor Ner-1 mRNA, complete cds 4490 9610 14703 2.4 5.20E-02 X58743.11 NT H.saplens HCK gene for tyrosine kinase (PTIK), exon 12 4490 9610 14704 2.4 5.2OE-02 X58743.11 NT H.sapiens HCK gene for Ine kinase (PTIK), exon 12 4633 9747 14843 1.0 5.2012-02 L33246.1 NT Drosophila melanogaster filament protein homolog (sepl) gene, complete cds WZp5471)073_rl 547 (synonym: hfbri) Homo saplens cDNA clone DKFZp547DO73 5' 2313 7416 1.0 5.1OE-02AL134071.1 EST HUMAN 3610 8749 13843 3.6 5.1OE-02 AF094269.11 NT HIV-1 Isolate 2001-4-37 from USA, envelope glycoproteln (eny) gene, partial cds ns69d01.sl NCI_PGAP-Pr2 Horno saplens cDNA done IMAGE:1 188865 similar to contains 3644 8783 5.8 5.1OE-02 AA652267.1 EST-HUMAN Alu repetitive element; contalns element PTR5 repetitive element; 474 5640 10766 0.7 5.0OE-02 AF098004.1 NT Mus musculus fatty acid amide hydrolase gene, exon 10 1186 6318 11474 2.4 5.OOE-02 Z99104.1 NT Bacillus subtills complete genome (section 1 of 2l): from 1 to 213080 SALIVARY ACIDIC PROLINE-RICH PHOSPHOPROTEIN 112 PRECURSOR (PRP-IIPRP-3) 1947 7064 12258 1.5 5.OOE-02 P0281 0 SWISSPROT (PRP-WPIRP-4) (PIF-FIPIF- S) (PROTEIN A/PROTEIN C) [CONTAINS: PEPTIDE P-C] 2788 6116 11274 0.6 5.OOE-02 U72742.11 NT Oryctolagus cuniculus UDP- glucuronosyttransferase (LIGT2B113) mRNA, complete cds 3295 8441 1.2 5.OOE-02 7305610 NT Mus musculus Unc-51 like kinase 2 (C. elegans) (U1k2), mRNA 3629 8168 13862 5.5 5.OOE-02 U112769.2 NT Antheraea emA period dock protein horn log mRNA, complete cds 4890 9997 15080 0.9 5.OOE-02 AF188530.1 NT Homo sapiens ubiquitous tetratricopeptide ntaining protein RoXaN mIRNA, partial cds mRNA, complete Chicken 28-kDa vitamin D-dependent caidum-binding protein (CaBP-28) 218 5410 9.9 4.9OE-02 M14230.1 NT cds 413 5581 1.9 4.9OE-02 D26607,11 NT Homo sapiens endothelial nitric oxide synthase gene, complete cds 3251 8398 13504 1.9 4.9OE-02 P54258 SWISSPROT ATROPHIN-1 (DENTATOROBRALPALLIDOLUYSIAN ATROPHY PROTEIN) zq48a112.s11 Stratagene hNT neuron (#937233) Homo saplens cDNA clone I MAGE:632926 3' similar to contains Alu repetitive element;contains element MSR1 repetitive element; 3522 8663 0.9 4.9OE-02 AA1 88940.1 EST HUMAN 3543 8684 13784 1.2 4.9OE-02 AA400914.1 EST HUMAN W8a03.sl Soare_tesUs_NHT Homo sapiens cDNA done IMAGE:728428 3' 3543 8684 13785 1.2 4.9OE-02 AA400914.1 EST HUMAN zt78a01s11 Soares testis NHT Homo sapiens cDNA done IMAGE:728428 3' 4733 9844 14936 1.9 4.9OE-02 AW167821.1, EST - HUMAN xq56gl 0.xl NCI_CGAF_Ut4 Horno sapiens cDNA done IMAGE:2632386 3' 4733 9844 14937 1.9 4.9OE-02 AW167821.1 EST-HUMAN xg56910.xl NCI CGAP UW Homo sapiens cDNA done IMAGE:2632386 3' 327 5509 10636 1.5 4.8OE-02 D16471.1 NT Human mRNA, Xq terminal portion 328 5509 10636 0.7 4.8OE-02 D16471.1 NT Human mRNA, Xq terminal portion 480 5646 10771 2,6 4.8012-02 AF003100.11 NT Arabidopsis allana AP2 domain containing protein RAP2,7 mRNA, partial ods zo49b02.sl Soares-senescenLfibroblast!k_NbHSF Homo sapiens cDNA done IMAGE:325611 Ysimilar to qb:M30938 LUPUS KU AUTOANTIGEN PROTEIN P86 2227 7334 12546 0.7 4.8OE-02 W51983.11 EST HUMAN (HUMAN); 3172 8321 13435 2.1 4.8OE-E X17144.11 NT Tetrallymena rostrata histone H311 and histone H411 Intergenic DNA 4572 9690 1.7 4.8OE-02 Z54280.11 NT S.scrofa gene for skeletal muscle ryanodin6 receptor 5076 10174 15254 1.3 4.8OE-02 U91914.1 NT Streptococcus constellatus D- alanine:D-alanine.ligase gene, partial cds 4940 10046 15118 0.8 4.7OE-02 6981261 NT Rattus norvegicus Nestin (Nes), mRNA 722 5876 11016 0.9 4.6OE-02 AE000445.1 NT Escherichia coil K-12 MG1655 section 335 of 400 of the complete genorne IMAGE:1538979 3'similar to am50d02.si Johnston frontal cortex Horno sapiens cDNA done 6399 1.1 4.6OE-02 A1014255.1 EST_HUMAN TR:1P90533 P9053i LIMA;contains element LTR1 repetitive element; Page 45 of 196 Table 4

2438 7537 12744 0.9 4.6OE-02 AW236023.1 EST HUMAN xn24f03.xl NCI WAP_Kidl 1 Homo sapiens c1DNA done IMAGE:2694653 Ysimilar to SW:GRIF11 HUMAN Q12849 G-RICH SEQUENCE FACTOR-1 2777 5457 10584 0.5 4.6OE-02 BE153583.1 EST HUMAN PMO-HT0339-251199-003- 905 HT0339 Horno sapiens cDNA 2977 8128 13235 1.0 4.6OE-02 BE153583.1 EST_HUMAN PMO-HT0339.251199-003- 905 HT0339 Homo sapiens cDNA 3451 8128 13235 1.0 4.6OE-02 BE153583.1 EST---HUMAN PMO-HT0339-251199-003- 905 HT0339 Homo sapiens cDNA 4033 9161 1.2 4.6OE-02 AF220365.1 NT Mus musculus nudeolar RNA helicase II/Gu (ddx21) gene, complete cds 439 5605 10739 0.6 4.5OE-02 P22448 SWISSPROT RETINOIC ACID RECEPTOR BETA (RAR-BETA) 1200 6332 11487 0.9 4.5OE-02 AF005730.1 NT Marburg virus strain WS. Afdca/Johannesburg/1975/Ozolin VP35 gene, complete eds 1200 6332 11488 0.9 4.5OE-02 AF005730.1 NT Marburg virus strain MIS. Africa/Johannesburg/1975/Ozolin VP35 ene,completecds 1763 6884 12067 1.3 4.5OE-02 P32182 SWISSPROT HEPATOCYTE NUCLEAR FACTOR 3- BETA (HNIF-313) 2063 7175 12382 0.7 4.5OE-02 AE003964.1 NT Xylelia fastidlosa, section 110 of 229 of the complete genome 3662 8801 13896 3.8 4.5OE-02 AL1 63278.2 NT Horno sapiens chromosome 21 segment HS21 C078 1008 6148 11302 1.3 4.4OE-02 L19295.1 NT Drosophila melanogaster extradenticle (EXD) mRNA, complete cds 2049 7162 2.2 4.4OE-02 P31568 SWISSPROT HYPOTHETICAL PROTEIN (ORIF 2280) 2440 7539 12746 1.3 4.4OE-02 AW875475.1 EST-HUMAN W2-PT0011 2-010300-070- g02 PT0011 2 Homo sapiens cDNA 3303 8448 13558 1.0 4.4OE-02 M64798.11 NT Methanobacterium formicicurn fdhC gene, complete ods 3588 8727 13823 1.9 4.4OE-02 AF159160.1 NT M)9gcoccus xanthus sednelthreonine kinase Pkn110 (pknlO) gen, complete cds 4527 9646 14735 1.1 4.4OE-02 AF109907.1 NT Homo saplens S164 gene, partial ods; PSI and hypothetical protein genes, complete cds; and S171 gene, partial cds 4527 9646 14736 1.1 4.4OE-02 AF109907.1 NT Homo saplens S164 gene. partial cds; PSI and hypothetical protein genes, complete cds; and S171 gene, partial cds 4637 9751 3,1 4.4OE-02 AJ222689.1 NT Ovis ades CCAAT-enhancer binding protein epsilon gene 1690 6814 1.2 4.3OE-02 T6791 1,1 EST HUMAN yc28a09.sli Stratagene liver (#937224) Homo sapiens cDNA done IMAGE:81976 3' similar to contains Alu repetitive element 3383 8526 13633 7,0 4.3OE-02 AL163210.2 NT Homo saplens chromosome 21 segment HS21 C01 0 3609 8748 1.1 4.3OE-02 AF060568.1 NT Horno saplens promyelocydc leukemia zJnc finger protein (PLZF) gene, complete cds 4334 9457 14545 3.5 4.3OE-02 F17181.2 EST HUMAN HSPD01704 HMI Horno sapiens cDNA done NOTAVAIL01704 5141 10236 15311 0.9 4.3OE-02 X51594.1 NT Pea P4 organ specific gene 878 6026 11186 0.8 4.2OE-02 AW003645.1 EST HUMAN wx34901.xl NCI - CGAP- Pitl Homo sapiens cDNA done IMAGE:2545584 Ysimilar to TR:Q63291 Q63291 L1 RETROPOSON, ORF2 MRNA;contains Ll.t3 L1 L1 repetitive element; 3117 8266 13370 0.9 4.2OE-02 A1493472.1 EST HUMAN qyg5f10.xl NCI WAP- Brn25 Horno, sapiens cDNA done IMAGE:2019787 Ysimflar to gb:M35718 FIBROBLAST GROWTH FACTOR RECEPTOR BFR-2 PRECURSOR (HUMAN); 5172 10266 1.1 4.2OE-02 D63484.1 NT Human mRNA for KIAA0150 gene. partial cds 2643 7732 12933 1.0 4.1OE-02 AE002330.2 NT Chlamydia muddarum, section 60 of 85 of the complete genome 3824 8961 14058 0.9 4.1OE-02 BE297236.1 EST-HUMAN 601177907F1 NIH MGC 17 Horno saplens cDNA clone IMAGE:3533353 5, 3824 8961 14059 0.9 4.1OE-02 BE297236.1 EST-HUMAN 601177907F1 N1H MGC 17 Homo saplens cDNA done IMAGE:3533353 5' 4372 9494 7.4 4.1 OE-02 AW893484.1 EST HUMAN QV1-NNO012-180400-164-f06 NNO012 Homo sapiens cDNA 2816 7967 13071 1.4 4.OOE-02 U18867.2 NT Mus musculus uroporphyrinogen lit synthase mRNA, complete ods 3206 8354 13464 2.7 AB040904.1 NT Homo sapiens mRNA for KIAA1471 protein, parda; cels 11616 1.3 4.OOE1-02 P41047 SWISSPROT FAS ANTIGEN LIGAND 0.0 3.9OE-02 Page 46 of 196 Table 4

1918 7035 12223 1.1 3.9OE-02 A.1403386.11 NT M.musculus DNA for desminbinding fragment DesD7 Homo saplens succinate dehydrogenase complex, subunit C, Integral membrane protein, 2671 7758 0.8 3.9OE-02 4506862 NT 15kD (SDHC) mRNA 5105 10201 15280 1.0 3.9OE-02 8924019 NT Horno sapJens hyj?pthedcal protein PR01 163 (PRO1 163), mRNA 5105 10201 15281 1.0 3.9OE-02 8924019 NT Homo saplens hypothetcal protein PRO1 163 (PRO1 163), mRNA 1568 6694 1.3 3.8OE-02 AJ229042.11 NT Homo saplens 959 kh config between AMLI and CBR1 on chromosome 21q22, segment 213 976 6121 11278 1.6 3.7OE-02 P19137 SWISSPROT LAMININ ALPHA-1 CHAIN PRECURSOR (LAMININ A CHAIN) _ _ Homo sapiens plasma membrane calcium ATPase Isoform 1 (ATP2131) gene, alternative 1366 6494 11660 0.9 3.7OE-02 L14561,1 NT splice products, pardal cds 2190 7299 125141 2.3 3.7OE-02 A1984806.1 EST-HUMAN wr85e08.xl NCI CGAR_ Wdll 1 Horno sapiens cDNA clone IMAGE:2494502 3' 2533 7629 12831 0.9 3.7OE-02 A130118261.1 NT Horno saplens mRNA for KIAA0718 protein, partial cds 3012 8164 13265 0.8 3.7OE-02 P79944 SWiSSPROT EOMESODERMIN Mus musculus potassium large conductance pH-sensidve channel, subfamily M, alpha 3408 8550 1.1 3.7OE-02 6680541 NT member 3 (Kcnma3), mRNA 3604 8743 13838 0.9 3.6OE-02 X73221.1 NT H.vulgare Ssl gene for sucrose synthase Horno sapiens genomic region containing hypervadable minisatellites chromosome 3612 8751 138451 0.8 3.6OE-02 AL0968065.1 NT 10[11 0q26.3] of Homo sapiens Homo sapiens genomic region containing hypervadable minisatellites, chromosome 5135 10230 153051 0.8 3.6OE-02 AL096810.1 NT 10[11 0q26.3] of Homo sapiens 877 6025 11185f.1.2 3.5OE-02 U09506.11 NT Drosophila melanogaster Uggdn mRNA, complete cds 992 6135 11290 0.5 3.5OE-02 AF253417.1 NT Homo sapiens microsomal epo)dde hydrolase (EPHXI) gene, complete ods 1188 6320 3,5 3.5OE-02 AW772365.1 EST-HUMAN hn72c08.xl NCI CGAP Kidl 1 Homo saplens cDNA clone IMAGE:3033422 3' EST69951 Human WhKe blood cells Homo saplens eDNA 5' end similar to Tcell receptor, 3271 8416 1.5 3.5OE-02 T29124.1 EST-HUMAN alpha chain, V region (HT:3229) 3663 8802 13897 0.9 3.5OE-02 X61 109.1 NT G.gorilia beta-globin gene 4120 9246 143301 2.0 3.5OE-02 AE001773.1 NT Thermotoga maddma section 85 of 136 of the complete genome CYSTATHIONINE BETA-LYASE PRECURSOR (CBL) (BETA-CYSTATHIONASE) 4220 9344 14427 1.4 3.5OE-02 P53780 SWISSPROT (CYSTEINE LYASE).

4536 9655 1.0 3.5OE-02 AW958469.1 EST-HUMAN EST370539 MAGE resequences, MAGE Homo sapiens cDNA 5154 10249 0.8 3.5OE-02 P47144 SWISSPROT HYPOTHETICAL 80.7 KI) PROTEIN IN SOD1-CIPA2 INTERGENIC REGION xv26d07.xl Soares_NFL-T-GBCSI Homo sapiens cDNA done IMAGE:2814253 3' similar to SW:C211_HUMAN P53801 PUTATIVE SURFACE GLYCOPROTEIN C21ORF1 1035 6175 113271 1.3 3.4OE-02 AW274020.1 EST-HUMAN PRECURSOR; 1817 6936 121261 0.6 3.4OE-02 AA398742.1 EST-HUMAN zt75f08.sli Soarss_testIs_NHT Horno sapiens cDNA done IMAGE:728199 3' yc20a06xl Stratagene.lung (#937210) Homo sapiens cDNA clone IMAGE:81250 V similar to 2343 7445 126521 0.8 3.4OE-02 T57160.1 EST-HUMAN contains MER29 repetitive element 3384 8527 13634 1.3 3.4OE-02 AL1 63208.2 NT Homo sapiens chromosome 21 segment HS21 C008 3845 8981 140821 3.2 3.4OE-02 AW794952.1 EST HUMAN RC6-LIM00115.21.0200- 021-AI0 UM0015 Homo sapiens cDNA 4494 9614 147061 2.4 1 3.4OE-02 X59799.11 NT M.musculus S-andgen gene promoter region 49 110095 3.4 3.4OE-02 1026457 ISWISSPROT I LA PROTEIN HOMOLOG (LA RiBONUCLEOPROTEIN) (LA AUTOANTIGEN HOMOLOG) j Page 47 of 196 Table 4

Page 48 of 196 5010 10112 15182 1.3 3.4OE-02 AJ012469.1 NT Caenorhabdids elegans mRNA for DYS-1 protein, partial 368 5546 4.5 3.3OE-02 AA398735.1 EST HUMAN zt75e08.sl Soares testis NHT Homo sapiens cDNA done IMAGE:728198 3' 1151 6286 11439 4.5 3.3012-02 AB035867.1 NT Cricetulus griseus CYP2A1 7 mRNA for cytochrome P450 2A1 7, complete cds 1621 6747 11915 1.1 3.3OE-02 AF1 10763.1 NT Homo sapiens skeletal muscle LIM-protelln 1 (FHLI) gene, complete cds 1705 6828 1.3 3.3OE-02 AE000700.1 NT Aquifex aeolicus section 32 of 109 of the complete genome 2038 7151 1.0 3.3OE-02 R09112.1 EST-HUMAN yf25c09xl Soares fetal liver spleen 1 NFLS Horno saplens cDNA clone IMAGE: 127888 5, 2448 7547 12755 1.1 3.3OE-02 TO2847.1 EST - HUMAN FB12A2 Fetal brain, Stratagene Homo saplens cDNA done FB12A2 Xend 2448 7547 12756 1.1 3.3OE-02 T02847.1 EST HUMAN FB12A2 Fetal brain. Stratagene Homo saplens cDNA done FB12A2 Xend 4086 6747 11915 2.2 3.3OE-02 AF1 10763.1 NT Horno saplens skeletal muscle LIM-proteln 1 (FHLI) gene, complete cds 4366 9488 14579 1.9 3.3OE-02 6755862 NT Mus musculus tumor rejection antigen gp96 (Tral), mRNA 127 5323 10455 1.1 3.2OE-02 AJ002005.1 NT Oryctolagus cuniculus gene encoding lleal sodium-dependent bile add transporter 1110 6247 11399 4.3 3.2OE-02 AF096275.1 NT Drosophila melanogaster heat shock protein 68 (hsp68) gene, hsp68d allele, complete cds 1110 6247 11400 4.3 3.2OE-02 AF096275.1 NT Drosophila melanogaster heat shock protein 68 (hsp68) gene, hsp68d allele, complete cds 1734 6857 12035 1.1 3.2OE-02 AF128894.1 NT Homo sapiens te lomerase reverse transcriptase (TERT) gene, exons 7-16 and complete cds 2072 7184 0.9 3.2OE-02 P28955 SWISSPROT LARGE TEGUMENT PROTEIN 2809 5323 10455 1.2 3.2OE-02 AJ002005.1 NT Oryetolagus cuniculus gene encoding ileal sodium-dependent bile acid transporter 3653 8792 13886 1.1 3.2OE-02 AL163203.2 NT Homo sapiens chromosome 21 segment HS21 C003 4124 9250 12.4 3.2OE-02 X94768.1 NT H.saplens RP3 gene (XLRP gene 3) 4658 9770 14865 2.9 3.2OE-02 AF1 14182.1 NT SayJfroga nidifica maturase (matK) gene, chloroplast gene encoding chloroplast protein, partial cds 1239 6368 0.7 3.1OE-02 4503416 NT Horno sapiens dual spedfidty phosphatase 4 (DUSP4) mIRNA 1283 6413 11575 1.3 3.1 OE-02 P18845 SWISSPROT NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA-3 CHAIN PRECURSOR (GF-ALPHA-3) 1501 6627 1.0 3.1OE-02 AF200465.1 NT Homo sapiens coxsackievirus and adenovirus receptor (CXADR) gene, complete cds. and ANA gene, partial cds 1850 6968 12153 1.4 3.1OE-02 6671564 NT Mus musculus adaptor-related protein complex AP-3, delta subunit (Ap3d), mRNA 1931 7048 1.1 3.1 OE-02 Z50097.1 NT Drosophila melahogaster mRNA for headcase protein 4767 9878 14972 1.0 3.1OE-02 AW835313.1 EST HUMAN QVO-LT0014-250200-129- h09 LT0014 Homo sapiens cDNA 1606 6733 1.0 3.OOE-02 AF187125.1 NT Pityoldelnes minutus cytochrome oyJdase 1 gene, partial ods; mitochondrial gene for mitochondrial product 2541 7637 12837 1.1 3.0011-02 AA402242.1 EST HUMAN zt65h03xl SoaresJestis NHT Homo sapiens cIDNA done IMAGE:727253 5' 3518 8650 13766 1.1 3.OOE-02 M94176.1 NT Saccharomyces cerevisiae stem- loop mutation supressor SSI-2 gene, complete cds 3685 8823 1.0 3.0OE-02 AW820223.1 EST-HUMAN QV2-ST0296-150200-040-e09 ST0296 Horno sapiens cDNA 3866 9002 1.2 3.OOE-02 AA364003.1 EST HUMAN EST74530 Pineal gland 11 Horno saplens cIDNA 6 end 2385 7942 12689 1,1 2.9OE-02 AF228703.1 NT Homo saplens mitochonddal glutathione reductase and cytosolic glutathione reductase (GRDI) gene, complete cds, alternatively s pliced 2449 7548 12757 0.5 2.9OE-02 4502F72 NT Homo saplens ATPase, Na+lK+ transporting, alpha 3 polypeptide (ATP1A3), mRNA Table 4

3851 8987 14087 0.9 2.9OE-02 H72805.1 EST HUMAN yu07e10xl Scares fetal liver spleen I NFLS Homo sapiens cDNA clone IMAGE:233130 5' 4950 10055 15125 1.3 2.9OE-02 X65137.1 NT S.vulgare pepC gene for PEP carbWase 4950 10055 15126 1.3 2.9OE-02 X65137.11 NT S.vulgare pepC gene for PEP carboxyjase 553 5716 0.9 2.8OE-02 AW970153.1 EST-HUMAN EST382234 MAGE resequences, MAGK_Homo sapiens cONA 3321 8465 13578 1.3 2.8OE-02 AF066063.1 NT Homo saplens retinal.fascin (FWN2) gene. exon 2 3321 8465 13579 1.3 2.8OE-02 AF066063.1 NT Homo sapiens rednal fascin ffiSCN2) gene, exon 2 4214 9338 1.0 2.8OE-02 8393751 NT Rattus norvegicus microtubuleassociated protein tau (Mapt), mRNA 1473 6600 11774 1.3 2.7OE-02 U66059.1 NT Human germline T-cell receptor beta chain Dopamine-beta-hydroxylase-like, TRY1, TRY2, TRY3, TCRBV27S1 P, TCR13V22S1A2N1T, TCR121V9S1AIT, TCR13V7S1AIN2T, TCRI3V5SIA1T, TCRI3V13S3, TCRI3V6S7P, TCR13M3A2T, TCR121V13S2A1T, TCR13V9S2A2PT, TCRBV7S2A1 N4T, TCRBV1 3S911 3S> 3385 8526 13635 20 2.7OE-02 AL161494.2 NT Arabidopsis thaflana DNA chromosome 4, condg fragment No. 6 4107 9233 14315 2.1 2.7OE-02 N47258.1 EST-HUMAN yy86h12xl Soares-muidple- scAerosis-2NbHMSP Homo saplens cDNA clone IMAGE:280487 5' 4107 9233 14316 2.1 2.7012-02 N47258.11 EST HUMAN yy86h12xl Soares_mulfiple-scJerosis2NbHMSP Homo sapiens cDNA done IMAGE:280487 5' 5194 10285 15352 1.0 2.7OE-02 A1825422.1 EST-HUMAN wb18e04.xl NCI CGAP GC6 Homo sapiens cDNA done IMAGE:2306046 3' 5194 10285 15353 1.0 2.7OE-02 A1825422.1 EST HUMAN wbl8e04.xl NCI CGAP GC6 Homo saplens dDNA done IMAGE:2306046 3' 559 5721 10837 1.1 2.6OE-02 AL163282.2 NT - Homo saplens chromosome 21 segment HS21C082 1345 6473 1.0 2.6OE-02 AW850515.1 EST-HUMAN IL3-CTO219-280100-062-CO9 CT0219 Homo sapiens cDNA 2315 7418 12625 1.1 2.6OE-02 AA490021.1 EST HUMAN abO2b02.sl Stratagene fetal retina 937202 Horno, saplens cDNA done IMAGE:839595 X 2317 7420 12627 1.0 2.6OE-02 6754241 NT Mus musculus hisddine rich calcium binding protein (Hrc), mRNA 2317 7420 12628 1.0 2.6OE-02 6754241 NT Mus musculus hisfidine rich calcium binding protein (Hrc). mRNA 2885 8036 1.6 2.6OE-02 AF1 09906.1 NT Mus musculus MI-IC class Ill region RD gene, partial cds; Bf, C2, G9A, NG22, G9, HSP70, HSP70, I-ISC70t, and smRNP genes. complete cds; G7A gene, partial cds; and unknown genes 3285 8430 13538 1.0 2.6OE-02 AF184597.1 NT Citrus unshiu ADP-glucose pyrophosphorylase small subunit (agpS) mRNA, complete ods 3883 9019 1.1 2.6OE-02 AW181945.1 EST-HUMAN A68f09xl Soares_INIFIL T GBC S1 Homo sapiens cDNA done IMAGE:2662409 3' 4811 9921 15013 3.7 2.6OE-02 L12032.1 NT Chicken dorsalin-1 mRNA, complete cds 4998 10101 15169 1.7 2.6OE-02 AE002014.1 NT Delnococcus radiodurans R1 section 151 of 229 of the complete chromosome 1 5025 10126 15199 2.1 2.6OE-02 AW241154.1 EST HUMAN xa52b04.xl NCI_PGAF_SE!r4 Homo saplens cDNA clone IMAGE:2570383 3' similar to SW:Y069LI-IUMAN Q15041 HYPOTHETICAL PROTEIN K1AA0069; 521 5685 10806 1.5 2.5OE-02 A1793130.1 EST-HUMAN on26f06.y NCI CGAF:_Lu5 Homo saplens ciDNA clone IMAGE:1557827 5, 521 5685 10807 1.5 2.5OE-02 A1793130.1 EST HUMAN on26f06.y5 NCI CGAP_Lu5 Homo saplens cDNA done IMAGE: 1557827 5' 1992 7108 12310 1.6 2.5OE-02 6680967 NT Mus musculus prooffilagen, type IV, alpha 3 (Col43), mRNA 2735 7819 0.9 2,50 -02 12571.1 N Rattus norvegicus rabphiiin-3A mRNA, complete cds 2926 8077 13184 4.4 2.50F 02 X99697.1 NT H.carterae mRNA for fucoxanthin chlorophyll alc binding protein, Fcpl 29261 8077 13185 4.4 2.5OE-02 X99697.11 NT H.carterac mRNA for fucoxanthin chlorophyll alc binding protein, Fcpl' Page 49 of 196 Table 4

Page 50 of 196 3376 8519 13625 1.0 2.5OE-02 BE464190.1 EST-HUMAN hx85c110.xl NCI - CGAP_Kidl 1 Homo saplens cDNA clone IMAGE:3194611 Ysimilar to gb:M16938 HOMEOBOX PROTEIN HOX-C6 (HUMAN); 4111 9237 14320 5,1 2.5OE-02 AW592114.1 EST HUMAN hf36h08.xl Soares NFL T GBC S1 Homo sapiens cDNA done IMAGE:2934015 3' 167 5361 10488 1.0 2.4OE-02 A1378582.1 EST HUMAN tc72c07.xl Soares Nhi- IMPu_SI Horno sapiens cIDNA done IMAGE:2070156 3' 1580 6706 11876 0.7 2.4OE-02 H65884.1 EST HUMAN yr75f11 1xl Soares fetal liver spleen 1 NFLS Homo saplens cIDNA clone IMAGE:211149 5, 1998 7932 12316 0.8 2.4OE-02 P01901 SWISSPROT H-2 CLASS 1 HISTOCOMPATIBILITY ANTIGEN, K-B ALPHA CHAIN PRECURSOR (H 2K(B)) 1998 7932 12317 0.8 2.4OE-02 P01901 SWISSPROT H-2 CLASS 1 HISTOCOMPATIBILITY ANTIGEN, K-B ALPHA CHAIN PRECURSOR (H 2K(B)) 4272 9397 14480 1.4 14-OE-02 J051 10.1 NT T.thermop ila calclum-binding 25 kDa (TC13P 25) protein mRNA, complete cds 4420 9540 14631 1.4 2.4OE-02 P01901 SWISSPROT H-2 CLASS 1 HISTOCOMPATIBILITY ANTIGEN, K-B ALPHA CHAIN PRECURSOR (H 2K(B)) 4420 9540 14632 1.4 2.4OE-02 P01901 SWISSPROT H-2 CLASS 1 HIST0COMPATIBILITY ANTIGEN, K-B ALPHA CHAIN PRECURSOR (H 2K(B)l) 5119 10215 11.5 2.4OE-02 A1-161595.2 NT Arabidopsis thaliana DNA chromosome 4, contig fragment No. 91 1829 6948 2.1 2.3OE-02 W05340.1 EST-HUMAN za84g08xl Soares fetaUung_NbHL19W Horno sapiens cDNA clone IMAGE:299294 5' 1844 6962 2.9 2.3OE-02 U94165.1 NT 4 Homo sapiens mammary tumor- associated protein INT6 (INT6) gene, exon 4 2302 7405 12613 0.9 2.3OE-02 Z74293.1 NT S.cerevislae chromosome IV reading frame ORF YD1-245c 3628 8767 13861 4.8 2.3OE-02 Z20377.1 EST HUMAN HSAAACADH P, Human foetal Brain Whole tissue Homo sapiens cDNA 4057 9184 14267 1.2 2.3OE-02 L24799.1 NT Gallus gall s conne)dn 45.6 (Cx45.6) gene, complete cds 4057 9184 14268 1.21 2.3OE-02 L24799.1 NT Gallus gallus conneyJn 45.6 (Cx45.6) gene, complete cds 4323 9446 14534 1.3 2.3OE-02 AW899107.1 EST HUMAN CM4-NNOOBO-290400-160- b04 NNO080 Homo sapiens cDNA 4348 10300 14561 0.9 2.3OE-02 AW593693.1 EST HUMAN xs25d08.xl NCI__CGAP_Ut2 Homo sapiens cDNA done IMAGE:2770671 X 4348 10300 14562 0,9 2.3OE-02 AW593693.1 ESTHUMAN xs25d08.xl NCI CGAP Ut2 Homo sapiens cIDNA done IMAGE:2770671 3' 4402 9523 14613 5.2 2.3OE-02 Z83867.1 NT Mycobacterium tuberculosis H37Rv complete genorne; segment 1361162 4472 9592 14687 1.8 2.3OE-02 BE143150.1 EST-HUMAN MRO-HT0159-151099-001- e03 HT0159 Homc, sapiens cDNA 4948 10053 16123 1.0 2.3OE-02 A1793177.1 EST HUMAN qz35c03.4 NCI_PGAP_KJdl 1 Horno sapiens cDNA done IMAGE:2028868 3' 4948 10053 15124 1.0 2.3OE-02 A1793177.1 EST HUMAN qz35c03.4 NCI CGAP Kidll l Horrio sapiens cDNA done IMAGE:2028868 3, 720 5874 11014 1.1 2.2OE-02 AF018267.1 NT Columba livia nudeo&de dipo- sphate kinase (NDPIK) gene, nuclear gene encoding mitochonddal protein, complete cds 1713 6836 0.6 2.2OE-02 4557448 NT Homo sapiens chromodomain helicase DNA binding protein 2 (CHD2) mRNA 1968 7083 12284 0.6 2.2OE-02 Z82001.1 NT S.pneurnonlae pcpA gene and open reading frames 2695 7952 12980 0,5 2.2OE-02 AF109633.1 NT Mus musculus ets variant protein ER81 gene, exons 1 through 4 3388 8531 1.9 2.2OE-02 AA577785.1 EST HUMAN nn24a04.s11 NCI CGAP Gasl Homo sapiens cDNA done IMAGE:1084782 3' 3595 8734 3.3 2.2OE-02 AF083094.1 NT Infectious bursal disease virus segment B strain IL4 VP1 gene, complete ods 3779 8916 14009 1.1 2.2OE-02 AW601317.1 ESTHUMAN PM0-13T0340-170100-004- b03 BT0340 Homo sapiens cDNA 3844 8980 14081 1.0 2.2OE-02 Z74293.1 NT S.cerevislae chromosome IV reading frame ORIF YD1-245c, 441 5607 2.7 2.1 OE-02 AF029726.1 NT Dictyostellum discoldeum hisfidine kinase C (dhkC) mIRNA, complete cds 1242 6371 11530 2.5 2.1OE-02 U72073.1 NT Bacillus subfills cotKILM cluster, Cot1K (cotK), Coti- (cotL), and spore coat protein CoN (cotM) genes, complete ods Table 4

1365 6492 11657 0.7 2.1OE-02 AF204395.1 NT Mus musculus macrophage migration inhibitory factor (MIF) gene, 6 flanking region and partial cds 1365 6492 11658 0.7 2.1OE-02 AF204395.1 NT Mus musculus macrophage migration inhibitory factor (MI F) gene, 9 flanking region and partial cds 1920 7037 12226 1.0 2.1OE-02 AF190899.1 NT Tegula aureotincta major acrosornal protein precursor (TMAP) mRNA, complete ods 2785 5915 11062 1.4 2.1OE-02 N29266.1 EST HUMAN yx43h07xl Scares melanocyte 2NbHM Homo saplens cDNA done IMAGE:264541 5' 3110 7105 12308 0.9 2.1OE-02 BE072546.1 EST HUMAN PM2-BT0546-1201 00-001 - fl 1 BT0546 Homo saplens cDNA 3110 7105 12309 0.9 2.10E.02 BE072546.1 EST-HUMAN PM2-13T0546-1201 00-001 -fl 1 BT0546 Rorno saplens cDNA 3535 8676 13779 1.2 2.1OE-02 AA461271.1 EST HUMAN zx63b09xl Soares_total- fetus-Nb2HF8-gw Homo saplens cIDNA clone IMAGE:796121 5 4038 916 14251 0.9 2.1OE-02 Z74293.1 NT S.cerevisiae chromosome IV reading frame ORF YD1-245c 4342 9465 14554 1.6 2.1OE-02 U44914.1 NT Boffelia burgdorferi plasmid cp32-2, erpC and erpD genes. complete cds; and unknown genes 4351 9473 14565 1.0 2.1OE-02 A1768127.1 EST HUMAN wg81dl 1.xl Soares_NSF- F8_9W-OT-PA-P-S 1 Homo sapiens c(DNA clone IMAGE:2371509 3' 4611 9725 14820 4.7 2.1OE-02 Y08501.1 NT A.thaliana mitochondrial genome, part A 4714 9826 14918 0,9 2.1011-02 A1823432.1 EST HUMAN wh54a05.xl NCI_PGAP Wdl 1 Homo saplens cDNA clone IMAGE:2384528 3' 18 5227 10328 2.7 2.OOE-02 AW895565.1 EST HUMAN QV4-NNO038-270400-187-h05 NNO038 Homo sapiens cDNA 259 5447 10572 0.9 2.OOE-02 6753635 NT Mus musculus DinB homolog 1 (E. cod) (Dinbl), mRNA 292 5478 10609 0.9 2.OOE-02 AA456538.1 EST-HUMAN aa15b10xl Soares Nhi- IMPu S1 Homo sapiens cDNA clone IMAGE:813307 5' 781 5933 11082 0.6 2.OOE-02 6753635 NT Mus musculus DinB hornolog 1 (E. coll) (Dinbl), mRNA 1071 6209 11362 1.0 2.OOE-02 AL096805.1 NT Homo sapiens; genornic region containing hypervadable minisatellites chromosome 1 [1 p36M1 of Homo sapiens 1181 6314 11470 0.6 2.OOE-02 8922391 NT Homo saptens hypothetical protein FLJ10379 (FLJ10379), mRNA 1181 6314 11471 0.6 2.OOE-02 8922391 NT Homo saplens hypothetical protein FLJ10379 (FLJ10379), mRNA 1830 6949 12132 0.8 2,0012-02 8922453 NT Homo sapiens h22!hedcal protein FLJ10486 (FI-J10486), mRNA 1830 6949 12133 0,8 2.0OE-02 8922453 NT Homo saplens hypothetical protein FLJ10486 (FLJ10486), mRNA 2768 7852 0.6 2.OOE-02 AL1 61532.2 NT Arabidopsis thaliana DNA chromosome 4, condg fragment No. 32 3105 8255 1.2 2.OOE-02 7305474 NT Mus musculus serna domain, transmembrane domain (TM), and cytoplasmic domain, (sernaphorin) 6B (Sema6b), mRNA 3189 8338 3.3 2.OOE- 2 AF095588.1 NT Arabidopsis thaliana C2H2 dric finger protein_FZF MRNA, complete cds 0 3925 9059 14146 1.5 2.OOE-02 M118095.1 NT P.vulgads hydroxyproline-dch glycoprotein (HRG) mRNA, Yend 5079 10177 15257 1.0 2.OOE-02 AL1 63278.2 NT Homo sapiens chromosome 21 segment HS21 C078 5085 10183 15262 1.0 2.OOE-02 AA456538.1 EST HUMAN aal5blO.rl Scares NhHMPu S1 Homo sapiens cDNA done IMAGE:813307 5' 678 5833 10964 0.6 1.9DE-02 AA572764.1 EST HUMAN rif19a07.sl NCI-CGAP_Prl Homo sapiens cDNA done IMAGE:914196 similar to contains Ll.tl Ll repetitive element; 1599 6726 11896 0,8 1.9OE-02 P18488 SWISSPROT EMPTY SPIRACLES HOMEOTIC PROTEIN 1993 71-02 12311 0.9 1.9OE-02 AL1 63303.2 NT Homo sapiens chromosome 21 segment HS21C103 1993 7102 12312 0.9 1.9OE-02 AL163303.2 NT Homo saplens chromosome 21 segment HS21 Cl 03 2458 7557 12762 0.9 1.9OE-02 AL161550.2 NT Arabidopsis thaliana DNA chromosome 4, config fragment No. 50 2875 8026 131.1 1.9OE-02 AA713856.1 EST HUMAN nwD4f05.sl NCI_PGAP_SS1 Homo sapiens cDNA done IMAGE:1238337 X Page 51 of 196 Table 4

3222 8370 0.8 1 19OE-02 AB03361 1,1 NT Urotrichus talpoides mitochondrial gene for cytochrome b, complete cds 3560 8699 1.3 1.9OE-02 N52250.1 ESTHUMAN yz281J02.sl Soares_mulfiple- sderosis-2NbHMSP Homo sapiens cIDNA clone IMAGE:284331 3' 3654 8793 13887 1.0 1.9OE-02 A1301183.1 EST HUMAN qn04c07.xl NCl-WAP-Lu5 Horno sapiens cDNA done IMAGE:1897260 Ysimilar to contains Su repetitive element; 3961 9093 14178 1.1 1.9OE-02 AF141940.1 NT Mycoplasma Imitans VihAl precursor (vihAl) and VihA2 precursor (AhA2) genes, partial cds 4099 9225 14309 1.5 1.90E-02 P09081 SWISSPROT HOMEOTIC BICOID PROTEIN (PRID-4) 4099 9225 14310 1.5 1.9OE-02 P09081 SWISSPROT HOMEOTIC BICOID PROTEIN (PRID-4) 4441 9561 14657 2.5 1.9OE-02 A1452999.1 EST HUMAN tj46d04.xl Soares_NSF_FMVV_07_PA,_SI Homo sapiens cIDNA done IMAGE:2144551 3'similar to contains Su repetitive element; 4944 7557 12762 1.9 1.9OE-02 AL161550.2 NT Arabidopsis thaliana DNA chromosome 4. config fragment No. 50 5291 1.1 1.8OE-02 09Z9HO SWISSPROT [PROTEIN-Pil] URIDYLY1-TRANSFERASE (P11 URIDYLYL-TRANSFERASE) (URIDYLY1.

REMOVING ENZYME) (UTASE) 343 5524 10649 1.4 1.8OE-02 AW771104.1 EST HUMAN hn52c06.xl NCLWAP_Co117 Horno saplens cIDNA done IMAGE:3027274 Ysimilar to contains element MER29 repetitive element; 1144 6279 11432 1.3 1.8OE-02 X17664.1 NT H.frandsd mIRNA for myelin basic protein (MBP) 1417 6545 11719 1.2 1.8OE-02 AF243382.1 NT Drosophila malanogaster cytoplasmic protein encore (enc) mRNA, complete cds 3174 8323 0.9 1.8OE-02 A1805829.1 EST HUMAN te52a09.xl Soares NFL T GBC S1 Homo saplens cIDNA clone IMAGE:2090296 3' 3489 8630 13742 1.1 1.8OE-02 Z75059.11 NT S.cerevislae chromosome XV reading frame ORF YORI 51 c 3812 8949 14045 1.1 1.8OE-02 AW879122.1 EST - HUMAN MR1-OT001 1-280300- 00"04 OT001 1 Homo sapiens cDNA 3812 8949 14046 1.1 1.8OE-02 AW879122.1 EST HUMAN MR1 -OT001 1-280300-009904 OT001 1 Homo sapiens cIDNA 3996 9128 1.2 1.8OE-02 AA8611446.1 EST HUMAN alk24h04.sl Soares testis NHT Horno sapiens cIDNA done IMAGE:1406935 3, 4332 9455 14543 1.4 1.8OE-02 AW936363.1 EST HUMAN QV4-DT0021-301299-071 - 1511 DT0021 Homo sapiens cDNA 4873 9980 15064 1.1 1.8OE-02 060810 SWISSPROT HYPOTHETICAL PROTEIN DJ845024.2 4887 9994 15075 1.1 1.8OE-02 A1288701.11 EST-HUMAN qm06b04.xl NCI CGAP Lu5 Homo sapiens cIDNA done IMAGE: 1881007 3' 888 6036 11194 1.3 1.70E-02 BE394869.1 EST HUMAN 601310626F1 NIH MGC 44 Homo saplens cIDNA done IMAGE:3632190 5' 1750 6872 12051 0.8 1.70E-02 AW573183.1 EST-HUMAN W34a03.xl Soares_NFL-T- GBC-Sl Homo sapiens cDNA done IMAGE:2933740 Ysimilar to contains 1-11.0 L1 repetitive element; 1750 6872 12052 0.8 1.70E-02 AW573183.1 EST-HUMAN W4a03.xl Soares - NFL T - G13Q_SI Homo sapiens cIDNA clone IMAGE:2933740 3' similar to contains Ll.tl 1.1 repifitive element; 1828 6947 1.1 1.70E-02 AL163204.2 NT Homo sapiens chromosome 21 segment HS21 C004 2066 7178 4.7 1.70E-02 A13004816.1 NT Oryctolagus cuniculus mIRNA for mitsugumin29 complete cds 2603 7693 1.4 1.70E-02 7657495 NT Homo saplen putative Rab5 G13P/G7P exchange factor homologue (RABEX5), mRNA 2968 8119 13227 0.9 1.70E-02 A1147615.1 EST HUMAN qb22a08.xl Soares_pregnantuterus-NbHPU Homo sapiens cDNA done IMAGE: 1696982 3, 3467 8608 4,2 1.70E-02 AW827368.1 EST HUMAN hm45a04.xl NCLCGAP_RDFl Homo sapiens cIDNA done IMAGE:3015534 Ysimilar to contains MER119.1b11 MER19 repetitive element; 3573 8712 0.9 1.70E-02 P04929 SWISSPROT HISTIDINE-RICH GLYCOPROTEIN PRECURSOR 4078 9205 1.0 1.70E-02 AA669618.11 EST HUMAN acl9fO4.sl Stratagene ovary (#937217) Homo sapiens cIDNA clone IMAGE:856927 Ysimilar to contains Alu repetitive element;contains element MER24 repetitive Page 52 of 196 Table 4

4105 9231 1.8 1.70E-02 R02506.1 EST-HUMAN ye86f08.rl Soares fetal liverspleen MFI-S Homo sapiens cDNA clone IMAGE:124647 5' 4427 9548 14641 1.2 1.70E-02 AW573183.1 EST-HUMAN M34a03.xl Soares-NFL-T- Gl3Q_SI Homo sapiens cDNA done IMAGE:2933740 Ysimilar to contains L1J1 L1 repetitive element; 4615 9729 14823 1.8 1.70E-02 V00641.1 NT Messenger RNA for anglerfish (Lophius arnericanus) somatostatin 11 4708 9820 5.3 1.70E-02 A1015076.1 EST HUMAN ov51c02.sl Soares tesds_NHT Homo sapiens cDNA clone IMAGE:1640858 X 4967 10070 15144 5.5 1.70E-02 AF105037.1 NT Mudd berpesvirus 4 complete genome 501 5665 0,5 1.6OE-02 AL021929.1 NT Mycobactedum tuberculosis H37Rv complete genome; segment 131162 1635 6761 11931 1.1 1.60E-02 Y18889.1 NT Treponema maltophilurn flaB2, flaB3 and fill) genes for flagellin subunit proteins and CAP protein homologue 2202 7311 12522 1.1 1.6OE-02 Q64176 SWiSSPROT LIVER CARBOXYLESTERASE 22 PRECURSOR (EGASYN) (ESTERASE-22) 2202 7311 12523 1,1 1.6OE-02 064176 SWISSPROT LIVER CARBOXYLESTERASE 22 PRECURSOR (EGASYN) (ESTERASE-22) 2518 76 4 12816 1.0 1.60E-02 AJ006345.1 NT Homo sapiens Wl-QT1 gene 2606 7696 12900 0.5 1.60E-02 AA484872.1 EST HUMAN ne81d06.sl NCI CGAP Ewl Homo sapiens cDNA done IMAGE:910667 2662 7751 1.1 1.60E-02 AB014534.1 NT Homo saplens mRNA for KIAA0634 protein, partial cds 3481 8622 13734 3.8 1.60E-02 AW850652.1 EST-HUMAN IL3-CTO219-160200-063- CO7 CT0219 Homo saplens cDNA 4084 9211 2.2 1.60E-02 AF1 10520.1 NT Mus musculus major histocompatibility complex region NG27, NG28, RPS28, NADH oxidoreductase, NG29, WC1, Fas-binding protein, BING1, tapasin, RaIGDS- like, KE2, BING4, beta 1,3-9alactosyl transferase, and RPS18 genes, complete cds; Sacm21 gene, partial> 4203 9328 14417 0.9 1.60E-02 AW875407.1 EST-HUMAN OV2-PT0012-140100- 030407 PT001 2 Horno sapiens cDNA 734 5888 8.5 1.5OE-02 8923734 NT Homo saplens transcription factor (HSA50894), mRNA 2095 7206 12411 1.4 1.50E-02 N39521.1 EST_HUMAN yv27b07M Soares fetal liver spleen 1 NFLS Homo saplens cDNA done IMAGE:243925 3' 2128 7238 12446 0.9 1.5OE-02 AL1 61594.2 NT Arabidopsis thallana DNA. chromosome 4, config fragment No. 90 3023 8175 13275 1.4 1.50E-02 A.1006216.1 NT Homo saplens CACNA1 F gene, exons 1 to 48 3023 8175 13276 1.4 1.5OE-02 AJ006216.1 NT Homo sapiens CACNA1 F gene, exons 1 to 48 3614 8753 1.2 1.5OE-02 AA458797.1 EST-HUMAN aa88c1O.sl Stratagene fetal retina 937202 Homo sapiens eDNA clone IMAGE:838386 3' 4049 9176 14259 1,2 1.5OE-02 AA1 60967.1 EST-HUMAN zq4091O.rl Stratagene hNT neuron'(#937233) Homo sapiens cDNA done IMAGE:632226 5' 411 5579 1.5 1.40E-02 AE002230.2 NT Chlarnydophila pneumoniae AR39. section 58 of 94 of the complete genome 1102 6240 11392 1.2 1.40E-02 7705980 NT Homo sapiens NESH protein (LOC51225), mIRNA 1236 6365 1.4 1.40E-02 U32800.1 NT Haemophilus influenzae Rd section 115 of 163 of the complete genome 1276 6406 1.0 1.40E-02 U67779.1 NT Xenopus laevis neul%enin related 1 b (X-WNRA b) mRNA, complete cds 1374 6502 0.9 1.40E-02 AF216854.1 NT Homo saplens headpin gene,:wmplete ods 3352 8496 13606 1.0 1.40E-02 AW074212.1 EST-HUMAN xb09d09.xl NCI CGAP GUI Homo, saplens cDNA done IMAGE:2575793 3' 3439 8581 13693 5.2 1.40E-02;AL161586.2 NT Arabidopsis thallana DNA chromosome 4, condg fragment No. 82 3439 8581 13694 5 ' 2 1.40E-02;AL161586.2 NT Arabidopsis thallana DNA chromosome 4, config fragment No. 82 3476 8617 13729 1.0 1.40E-02 4503628 NT Homo sapienswagulation factor XII (Hageman factor) (F12), mRNA 1Mus 8745 138401.40E-02 6996918 NT musculus histocompatibility 2, complement component factor S (H2-BO, mRNA C.^ Page 53 of 196 Table 4

4387 9509 14594 7.3 1.40E-02 AW962688.1 EST-HUMAN EST374761 MAGE resequences. MAGG Homo sapiens cIDNA 4387 9509 14595 7,3 1.40E-02 AW962688.1 EST HUMAN EST374761 MAGE resequences, MAGG Homo sapiens cIDNA 1912 7029 12216 0.9 1.30E-02 AL163201.2 NT Homo sapiens chromosome 21 segment HS21C001 3888 9024 1.4 1.30E-02 AF169288.1 NT Mus musculus beta-sarcoglycan gene, complete ods 5176 7029 12216 1.0 1.30E-02 AL163201.2 NT Homo sapiens chromosome 21 segment HS21 C001 206 5399 0.9 1.20E-02 X87344.1 NT H.sapiens DMA, DMB, HLA-Zl, IPP2, LIVIP2, TAP1, LMP7, TAP2, DOB, DQB2 and RING8, 9, 13 and 14 genes 352 5532 10660 0.6 1.20E-02 AA059299.1 EST HUMAN zf65g01.rl Soares retina N2b4HR Homo sapiens cIDNA clone I MAGE:381840 5'similar to contains element L1 repetitive element; 445 5611 10742 1.5 1.20E-02 P38898 SWISSPROT HYPOTHETICAL 17.1 KID PROTEIN IN PUR5 YREGION 721 5875 11015 1.0 1.20E-02 AI 183522.1 EST-HUMAN qd68e12.xl SoaresJestis NHT Homo sapiens cIDNA clone IMAGE:1734670 Ysimilar to contains LIAI 1.1 repeddvjeiement; 2130 7240 12448 0,7 1.20E-02 AL163213.2 NT Homo saplens chromosome 21 segment HS21 C01 3 2393 7493 12699 1.2 1.20E-02 AW172350.1 EST-HUMAN xj37e09.xl Soares NFL T GBC S1 Horno sapiens cDNA clone IMAGE:2659432 3' 2596 7493 12699 1.3 1.20E-02 AW172350.1 EST HUMAN xj37e09.xl Soares_NIFL. J GBC S1 Homo sapiens cDNA done IMAGE:2659432 3' 3063 8214 6.2 1.20E-02 AA075418.1 EST HUMAN zm88e03xl Stratagene ovarian cancer (#937219) Homo sapiens cIDNA clone IMAGE:545020 T 3250 8397 13503 1.9 1.20E-02 R62805.1 EST-HUMAN vil 1b0B.sl Soares placenta NWHP Homo sapiens cDNA done IMAGE:1 38903 X 4830 9938 15027 2.0 1.20E-02 U91328,1 NT Human hereditary haemochromatosis region, histone 2A-like protein gene, hereditary haemochromatosis (HLA-H) gene, RoRet gene, and sodium phosphate transporter (NPT3) gene, complete cds 4974 10077 1.7 1.20E-02 A13019786.1 NT Cynops pyrrhogaster CpUbiqT mRNA, partial cds 1248 6377 11536 1.3 1.1OE-02 AA070364.1 EST-HUMAN zm69el 1.sl Stratagene neuroepithellum (#937231) Homo sapiens cIDNA done IMAGE:530924 3' 1679 6803 11983 0.7 1.1OE-02 X75491.1 NT H.sapiens LIPA gene. exon 4 1679 6803 11984 0.7 1.1OE-02 X75491.1 NT H.sapiens LIPA gene, exon 4 2848 7999 3.5 1.1OE-02 N99523.1 EST_HUMAN za40e05xl Soares fetal Ii ver spleen 1 NFLS Homo sapiens cDNA clone IMAGE:295040 5, 2933 8084 13192 10.4 1.1OE-02 AF055066.1 NT Homo sapiens WC class 1 region 3478 8619 13732 2.5 1.1OE-02 A1653508.1 EST HUMAN tq95b10.xl NCI WAP_Ov23 Homo sapiens cIDNA clone IMAGE:2216539 Ysimilar to SW:XPIF-HUIVIZN 092889 DNA-REPAIR PROTEIN COMPLEMENTING XP-F CELL; 3937 9071 0.9 1.1OE-02 BE144637.1 EST HUMAN PM3-HT0175-300999-001-h06 HT0175 Homo sapiens cIDNA 4016 9146 1.0 1.1OE-02 AW813796.1 EST HUMAN RC3-ST01 97-120200-01 5-gl 1 ST01 97 Homo saplens cIDNA 4723 9835 14927 1.8 1.1OE-02 AL048383.2 EST HUMAN DKFZp586E0924j11 586 (synonym: hutel) Homo sapiens cDNA done WZp586E0924 4821 9930 0,9 1.1OE-02 AW820281.1 EST-HUMAN QV2-STO2gri150200-028-cl 1 ST0296 Homo sapiens cDNA 6 5214 10317 1.1 1.0OE-02 AW846120.1 EST - HUMAN MR3-CT0176.111099-003- e10 CTO176 Homo sapiens cIDNA 1506 6633 11802 0.9 1.OOE-02 AW368128.1 EST - HUMAN CM2-HT0177-041099-017- h12 HT0177 Homo sapiens cDNA 2525 7621 1.2 1.OOE-02 AA806389.1 EST HUMAN oc22h08.sl NCI CGAP_GCB1 Homo sapiens cIDNA. done IMAGE:1 3M95 3' 3464 8605 1.0 1.OOE-02 AW845621.1 EST_HUMAN MRO-CTO060-081099-003-h10 CTO060 Homo sapiens cIDNA 3805 89421 14037 0.8 11.0OE-02 A1065086.1 EST HUMAN HA0921 Human fetal liver cDNA library Homo sapiens cDNA Page 54 of 196 Table 4

4667 9779 14877 4.3 1.0OE-02 6753521 NT Mus musculus cordcotropin releasing hormone receptor 2 (Crhr2), MRNA 4736 9847 14939 2,4 1.0012-02 R96567.1 EST-HUMAN yq54h01xl Soares fetal liver spleen 1 NFLS Homo sapiens cDNA clone iMAGE:199633 5' 4995 10098 15165 0.9 1.OOE-02 AF21 8910.1 NT Homo saplens attractin precursor (ATRN) gene, exon 25 and complete cds, alternatively spliced 875 6023 11183 0.6 9.OOE-03 A1796126.1 EST-HUMAN wh42f09.xl NCI_PGAP_Kidl l Homo sapiens cDNA done IMAGE:2383433 Ysimilar to contains element MER22 MER22 repetitive element; 2346 7448 12655 1,2 9.OOE-03 AL161559.2 NT Arabldopsis thallana DNA chromosome 4, condg fragment No. 59 2593 7685 12887 1.1 9.OOE-03 AJ243727.1 NT Oncorhynchus nerka proviral gypsy retrotransposon partial reverse transcriptase and protease genes (pot gene) 2593 7685 12888 1.1 9.OOE-03 AJ243727.1 NT Oncorhynchus nerka proviral gypsy retrotransposon partial reverse transcriptase and protease genes (pol gene) 2876 8027 13129 0.8 9.OOE-03 A1251744.1 EST HUMAN gh90109.xl Soares_NFL, GBC S1 Homo saplens cDNA done IMAGE: 1854281 3' 2876 8027 13130 0.8 9.OOE-03 A1251744.1 ESTHUMAN gh90f09.xl Soares,-NFGBC S1 Homo sapiens cDNA done IMAGE:1854281 3' 3617 8756 13849 0.9 9.OOE-03 J05184.1 NT S.addocaldadus thermopsin gene, complete ods 4914 10021 15100 1.2 9.OOE-03 BE047949.1 EST-HUMAN tz44e10.yl NCI CGAP_8m52 Homo sapiens cDNA done IMAGE:2291466 5' 5181 10273 2.6 9.OOE-03 AF137240.1 NT Sargocentron sp. mixed lineage leukemia-like protein (M11) gene, partial cds 493 5658 1.1 8.OOE-03 AA723007.1 EST-HUMAN zh30a03.sl Soares_plneal_giand_N3HPG Homo saplens cDNA clone I MAGE:413596 Y similar to contains AAu repetitive element:

973 6119 11276 15.0 8.OOE-03 AF106656.1 NT Homo saplens adenylosuccinate Iyase gene, complete cds 2113 7224 12432 0,9 8.OOE-03 AL163283.2 NT Homo sapiens chromosome 21 segment HS21 C083 2930 8081 0.9 8.0012-03 U47048.1 NT Escherichia coli microdn 24 region. DNA binding protein (mdbA). Immunity protein (mtfl), microdn 24 (mtfS), and microcin transport protein (mtfA, mtfe) genes, complete ods 3270 8415 13522 1.0 8.OOE-03 BE171225.1 EST-HUMAN RC1-HT0545.120200-01 1- b09 HT0545 Homo sapiens cDNA 3314 8459 13571 0.9 8.OOE-03 AJ131016.1 NT Homo saplens SCL gene locus 3792 8929 1.1 8.OOE-03 AF058764.1 NT Xenopus laevis bone morphogenedc Rrotein i (BIVIP-4) gene. complete cds 679 5834 10965 3.9 7.OOE-03 AF097183.1 NT Cryptospo dium parvum HC-10 gene, complete cds 679 5834 10966 3.9 7.OOE-03 AF097183.1 NT Cryptospoddium parvum HC-10 gene, complete cds 1341 6469 1.2 7.OOE-03 Q61060 SWISSPROT FORKHEAD BOX PROTEIN D3 (HNF3/FH TRANSCRIPTION FACTOR GENESIS) (HEPATOCYTE NUCLEAR FACTOR 3 FORKHEAD HOMOLOG 2) (HFH-2) 1373 6501 11667 5.0 7.OOE-03 AA668298.1 EST-HUMAN ab79b09.sl Stratagene fetal retina 937202 Homo sapiens cDNA clone IMAGE:853145 3' 1486 6613 11783 1.7 7.OOE-03 AW303599.1 EST-HUMAN b02.xl Soares NFI.,,, GBC S1 Homo saplens cDNA clone IMAGE:2813739 3' 2210 7937 12533 0.8 7.OOE-03 P04929 SWISSPROT HISTIDINE-RICH GLYCOPROTEIN PRECURSOR 3127 8276 13382 1.1 7.OOE-03 AW503321.1 EST-HUMAN Ut-HF-BNO-akx-d-03-0-Ul. rl NIH-MGC-50 Homo saplens cDNA done IMAGE:j078580 5' 3702 8841 13932 1.3 7.OOE-03 AW444463.1 EST_HUMAN Ul-H-B]3-akb-c-10-0-Ul. sl NCI-CGAP_SubS Horno saplens cIDNA done IMAGE:2733691 3' 374 8878 1.0 7.OOE-03 AF196344.1 NT Rattus norvegicus neuronal nicotinic acetylcholine receptor subunit (Alphal 0) mRNA, complete cds lin J_ Page 55 of 196 Table 4

4434 9555 1.2 7.OOE-03 AW117711.1 EST-HUMAN xe34f09.xl NCI - WAIR_Utl Homc sapiens cIDNA done IMAGE:2609033 Ysimilar to TR:C112987 Q12987 ACIDIC 82 KDA PROTEIN.; 4495 9615 1.0 7.OOE-03 AW630888.1 EST HUMAN hh89a05.yl NCI_WAP GU1 Horno, sapiens cDNA done IMAGE:2969936 9 4916 10023 1.8 7.OOE-03 AL1 63278.2 NT Homo sapiens chromosome 21 segment HS21 C078 5038 10138 15215 1.1 7.OOE-03 BE044191.1 EST HUMAN ho39h08.xl Soare_NFL-TGBC_Sl Horno sapiens cIDNA done IMAGE:3039807 Ysimilar to TR:093434 093434 RETICULOCALBIN.; 5038 10138 15216 1.1 7.OOE-03 BE0441 91.1 EST-HUMAN ho39h08.xl Soares - NFGBC,_SI Homo sapiens cIDNA done IMAGE:3039807 Ysimilar to TR:093434 093434 RETICULOCALBIN.; 1220 6351 11511 3.2 6.OOE-03 AW511148.1 EST HUMAN W22a05.xl Soares - NFL - T - G13Q._S1 Homo saplens cDNA clone IMAGE:2910224 Ysimilar to SW:PXR-HUMAN 075469 ORPHAN NUCLEAR RECEPTOR PXR; 1220 6351 11512 3.2 6.OOE-03 AW511148.1 EST-HUMAN W22a05.xl Soares-NFL-T- WC,_S1 Homo, sapiens cIDNA clone IMAGE:2910224 Ysimilar to SW:KR-HUMAN 075469 ORPHAN NUCLEAR RECEPTOR PXR; 2744 7828 13031 1.1 6.OOE-03 AF1 12374.1 NT Danio redo odorant recept6r gene cluster 2862 8013 13113 3.1 6.OOE-03 AA759135.1 EST HUMAN ah78el I.sl Soares tesds_NHT.Homo sapiens cDNA done 1321772 3, 2862 8013 13114 3,1 6.OOE-03 AA759135.1 EST-HUMAN ah78ell.sl Soares tesds, _NHT Homo sapiens cDNA done 1321772 3 3208 8356 2.1 6.OOE-03 H75690.1 EST-HUMAN yr77h04xl Soares fetal liver spleen INFI-S Homo sapiens cDNA clone IMA. GE:211351 5' 3336 8480 13594 1,2 6.OOE-03 U90880.1 NT Fugu rubripes zinc finger protein, isotodn, fatty add binding protein, sepiapterin reductase and vasotocin genes. complete cds 3336 8480 13595 1,2 6.OOE-03 U90880.1 NT Fugu rubripes 7:1nc finger protein, lsotocin, fatty add binding protein, sepiapterin reductase and vasotocin genes, complete cds 3499 8641 1.1 6.OOE-03 W37985.1 EST-HUMAN zcl 3al I.rl Soares_parathyroldturnor-NbHPA Homo sapiens cDNA clone IMAGE:322172 5' 3711 8849 13939 1.3 6.OOE-03 6754029 NT Mus musculus glucosamine-6- phosphate deaminase (Gnpi), mRNA 3846 8982 14083 0.9 6.OOE-03 AW847284.1 EST HUMAN RCO-CTO204-240999-021- blO CT0204 Homo sapiens ciDNA 3873 9009 1.2 6.OOE-03 BE250108.1 EST HUMAN 600942904F1 N1H MGC 15 Horno, sapiens cDNA done IMAGE:2959513 5' 4231 9355 0.9 6.OOE-03 N58946.1 EST-HUMAN yy62h1O.sl Soares_muldpie- sderosi5_2NbHMSP Homo sapiens cIDNA clone IMAGE:278179 3' 4267 9392 1.4 6.OOE-03 A1016833.1 EST HUMAN ov33cl 1.xl Soares tesfi!_NHT Homo saplens cIDNA done IMAGE:1 639124 3' 4597 9711 14803 6.8 6.OOE-03 AA324242.1 EST-HUMAN EST27116 Cerebellum 11 Homo sapiens cDNA S end similar to EST containing Alu repeat 5115 10211 15290 1.8 6.OOE-03 A1-163281.2 NT Horno sapiens chromosome 21 segment HS21 C081 5129 10224 15299 0.9 6.0OE-03 AA889972.1 EST HUMAN aj95g09.sl Soares_parathyrold-tumoLNbHPA Homo saplens cDNA done IMAGE:1404256 3' 653 5811 10938 0.7 5.OOE-03 L25105.1 NT Chlamydia trachornatis partial ORFB; amincacyl-tRNA synthase, complete cds; complete ORFA, and grpE-like protein, complete ods 653 5811 10939 0.7 5.OOE-03 L25105.1 NT Chlarnydia trachomatis pardal ORFB; aminoacyl-tRNA synthase, complete cds: complete ORFA, and grpE-like protein, complete cds 5811 10938 1.0 5.OOE-03 L25105.1 NT Chlamydia trachomatis partial ORFB; aminoacyl-tRNA synthase, complete cds; complete an grpE-like protein, complete ods 5811 10939 1,0 5.OOE-03 L25105.1 NT Chlarnydia trachornatis partial ORFB; aminoacyl-tRNA synthase, complete cds; complete ORFA, and grpE-like protein, complete ods Page 56 of 196 Table 4

1096 6234 11386 1.4 5.OOE-03 AJ010457.1 NT Arabidopsis thaliana mRNA for DEAD box RNA helicase,RH3 1115 6252 11402 1.3 5.OOE-03 AW293363.1 EST-HUMAN Ul-H-BI2-ahl-d-06-0-Ul. sl NCI-PGAP-Sub4 Homo sapiens cONA clone IMAGE:2727203 3, 1115 6252 11403 1.3 5.OOE-03 AW293363.1 EST-HUMAN Ul-H-B12-ahl-"6-0-Ul.si NCLCGAP-Sub4 Horno sapiens cDNA done IMAGE:2727203 3, 1552 6679 0.9 5.OOE-03 A1138977.1 EST HUMAN gd79d05.xl Scares tesds NHT Homo saplens cDNA done IMAGE:1735689 3' 2648 7737 12937 1.2 5.OOE-03 A13033006.1 NT Horno saplens mRNA for K1AA11 180 protein. partial ods 2905 8056 13161 1.0 5.OOE-03 BE266057.1 EST-HUMAN 601194798F1 N1H IVIG9_7 Homo saplens cDNA clone IMAGE:3538799 5, 3097 8248 13352 4.1 5.OOE-03 T87623.1 EST HUMAN yc81f09.sl Scares Infant brain 1NIB Homo sapiens cDNA done IMAGE:22395 3, 3116 8265 1.8 5.OOE-03 AL161491.2 NT Arabidopsis thaliana DNA chromosome 4. condg fragment No. 3 3129 8278 13385 1.0 5.0012-03 R71794.1 EST-HUMAN yj86g02.sl Scares breast 2NbH13st Honno saplens cDNA done IMAGE:155666 3, 3240 8387 1.1 5.OOE-03 AJ297357.1 NT Homo sapiens partial LIMD1 gene for LIM domains containing protein 1 and KIAA0851 gene 3641 8780 13873 4.2 5.OOE-03 AF147449.2 NT Pseudomonas aeruginosa strain PA01 penicillin-binding protein 1 B (ponB) gene, complete ods 3698 8837 13928 0.8 5.OOE-03. U38914.1 NT Citrus sinensis seed storag protein dtrin mRNA, complete cds 3890 9026 1.4 5.OOE-03 AA299675.1 EST HUMAN EST12218 Uterus tumor 1 Horno saplons cDNA Vend 4207 9332 14418 0.9 5.OOE-03 H78355.1 EST HUMAN yu7991O.rl Scares fetal liver spleen 1INFI.S Horno saplens cDNA clone IMAGE:240066 S' 4209 8837 13928 0.9 5.OOE-03 U38914.1 NT Citrus sinensis seed storage protein dhin mRNA, complete ods 4503 9622 14713 0.9 5.OOE-03 AJ131016.1 NT Homo sapiens SCL gene locus 4619 9733 14828 2.5 5.OOE-03 A1752367.1 EST-HUMAN cnl5c02.xl Normal Human TrabeWar Bone Cells Horno sapiens cDNA clone NW13C-cn15c02 random 232 5423 10547 1.0 4.OOE-03 AW500196.1 EST HUMAN Ul-HF-BNO-akc-b-04-0-Ul. rl NIH-MGC-50 Homo saplens cDNA done IMAGE:3076831 51 318 5502 10629 0.7 4.OOE-03 R46482.1 EST HUMAN yg51 e04.sl Scares Infant brain 1 NIB Horno sapiens cIDNA done IMAGE:35988 3' 436 5602 10735 0.9 4.OOE-03 P54675 SWISSPROT PHOSPHATIDYLINOSITOL 3- KINASE 3 (P13-KINASE) (PTDINS-3-KINASE) (P13K) 588 5748 10865 1.0 4.OOE-03 AA939339.1 EST-HUMAN on75g12.sl Soare_NFGBCAl Homo saplens cDNA clone IMAGE:1 562566 X 859 6007 11169 0.6 4.OOE-03 R4"82.1 EST-HUMAN Vg51e04.sli Scares Infant brain 1 NIB Homo saplens eDNA done IMAGE:35988 3, 893 6F41 1.2 4.00FE-03 AW749101.1 EST-HUMAN RC3-BT0333-110100-012-f01 BT0333 Horno sapiens cONA 1133 6269 11421 11.0 4.OOE-03 AA099777.1 EST-HUMAN z181a08.rl Stratagene colon (#937204) Horno saplens cONA clone IMAGE:510998 5' 1153 6288 11442 0.5 4.OOE-03 AW794740.1 EST_HUMAN RC6-UM00114-170400-023- GO1 UM0014 Homo sapiens eDNA 1281 6411 11572 1.3 4.0OE-03 AA28.4374.1 EST HUMAN zs59a0I.rl NWGAP GC131 Horno sapiens cONA done IMAGE:701736 5' 1709 6832 12012 0.8 4.OOE-U3 U33472.1 NT Rattus norvegicus type 1 astrocyte and olfactory-limbic associated protein AT1 -46 mRNA, complete cds 1971 7086 12289 7.6 4.OOE-03 AA099777.1 ES'_HUMAN z1181aO A Stratagene colon (#937204) Homo sapiens cDNA clone IMAGE:510998 V 2200 7309 0.6 4.OOE-03 BE4105561 EST HUMAN 601304161 F1 NIH_MCj21 Homo sapiens cDNA clone IMAGE:363851 0 6 2232 7339 12551 0.5 4.OOE-03 AW794740.1 EST HUMAN RC6-UM0014-170400-023- GO1 UM0014 Horno sapiens cDNA Page 57 of 196 Table 4

2526 7622 12822 0.7 4.OOE-03 U52111.2 NT Homo sapiens X28 region near ALD locus containing dual specificity phosphatase 9 (DUSP9), dbosomal protein Ll 8a (RPL1 8a), Ca2+1Calmodulin-dependent protein kinase i (CAMI(I), creatine transporter (CRTR), WM protein (CDM), adrenoleukedystrophy protein > 2526 7622 12823 0,7 4.OOE-03 U5211 1.2 NT Horno, sapiens X28 region near ALD locus containing dual specificity phosphatase 9 (DUSP9), ribosomal protein Ll Ba (RPL1 8a), Ca2+1Calmodulin-dependent protein kinase 1 (CAMKI), creatine transporter (CRTR), CDM protein (CDM), adrenoleukodystrophy protein > 2664 7752 12950 1.0 4.OOE-03 AL163284.2 NT Homo sapiens chromosome 21 segment HS21 C084 3487 8628 13739 0.9 4.0012-03 AW188426.1 EST HUMAN x198f04.xl NCI_CW Col 8 Homo sapiens NA clone IMAGE:2665279 3' 3487 8628 13740 0.9 4.OOE-03 AW188426.1 ES_HUMAN xj98fO4.xl NCI CGAP Col 8. Homo sapiens cIDNA done IMAGE:2665279 3, 3572 8711 13810 0.8 4.OOE-03 Q13606 SWISSPROT OLFACTORY RECEPTOR 511 (OLFACTORY RECEPTOR-LiKE PROTEIN OLF1) 3836 8711 13810 0.8 4.OOE-03 013606 SWISSPROT OLFACTORY RECEPTOR 511 (OLFACTORY RECEPTOR-LIKE PROTEIN OLF1) 3852 8988 14088 0.9 4.OOE-03 AF060868.1 NT Mus musculus tumor susceptibility protein 101 Qs9101) gene, complete cds 3914 9048 1.8 4.OOE-03 AJ011712.1 NT Homo sapiens TNNT1 gene, exons 1 -11 (and joined CDS) 4509 9628 14722 1.1 4.OOE-03 A1732754.1 EST_HUMAN ab18a08.x5 Stratagene lung (#937210) Homo saplens cIDNA clone IMAGE:841142 Ysimilar to contains AJu repetitive element; 4842 9949 15038 0.8 4.OOE-03 ALl 63301.2 NT Horno, sapiens chromosome 21 segment HS21 C101 5164 10258 15328.13.2 4.OOE-03 J02187.11 NT Foot and mouth disease virus serotype A-1 2 11 9ab capsid protein VP3 367 5545 10678 0.6 3.OOE-03 AF01 1920.1 NT Homo saplens protein kinase CK2 catalytic subunit alpha gene, exon 1 861 6009 11170 2.6 3.OOE-03 AF011920.1 NT Homo sapiens protein kinase CK2 catalytic subunit alpha gene, exon 1 1458 6585 11759 0.8 3.OOE-03 AI 133024.1 EST HUMAN HA1 611 Human fatal liver ciDNA library Homo sapiens cDNA 1638 6764 11933 0.7 3.OOE-03 AA4681 10.1 EST HUMAN nc73c05,sl! NCI-CGAP- Pr2 Homo sapiens cIDNA done IMAGE:782984 similar to contains AJu repetitive elernent; 1707 6830 1.0 3.0012-03 X87344.1 NT H.sapiens DMA, DIVIB, HLA-Zl, IPP2, LIVIP2, TAP1, LIVIP7, TAP2, DOB, DQB2 and RING8, 9, 13 and 14 genes 2211 7319 0,9 3.OOE-03 AF055066.1 NT Homo sapiens MHC class 1 region 2248 7354 1.4 3.OOE-03 Z32521.1 NT S.cereale (cv. Halo) mRNA for triosephosphate Isomerase 2249 7355 12561 1.1 3.OOE-03 AJ271004.1 NT Mus musculus TFF3liTF gene for Trefoil Factor 3/Intestinal Trefoil Factor protein, exons 1-3 2249 735 12562 1.1 3.OOE-03 AJ271004.1 NT Mus musculus TIFF3/ITF gene for Trefoil Factor 3/Intesfinal Trefoil Factor protein, exons 1-3 2683 7770 12970 4.0 3.OOE-03 AF034863.1 NT Rattus norvegicus Wapfic. scatfolding molecule (S-SCAM) mRNA, complete cds 2963 8114 0.8 3.OOE-03 Y09006.11 NT Arabidopsis thallana rpoMt gene 3044 8195 13297 4.5 3.0012-03 BE379296.1 EST HUMAN 601237982F1 N1H - MGQ_44 Homo saplens cIDNA done IMAGE:3609933 5, 3112 8261 13365 2.6 3.OOE-03 AW802687.1 EST HUMAN 11-2-LIM0076-240300-056- 1303 UM0076 Horno sapiens cDNA 3371 8514 13621 2.0 3.OOE-03 U34606.1 NT Mus musculus alpha-l(XVIII) collagen (COL18A1) gene, exon 1 and 2 379 8522 6.8 3.OOE-03 Y112500.1 NT Rmdcgene 3950 9083 14164 1.6 3.OOE-03 A1792278,1 EST HUW 77essler Wilms tumor Homo saplens cDNA done I MAGE:1 155689 5' 4058 9185 2. 2.22-23 Z32521.1 v. Halo) mRNA for tdosephosphate Isomerase 1942A0 14510 a ' n"._")qIcus gdnf gene 0 11 1 Page 58 of 196 Table 4

4417 9537 14628 4.4 3.OOE-03 A1536141.1 EST-HUMAN xu8.Pl 0.1---13conorm Homo saplens cIDNA 3' 4630 9744 14841 0,9 3.OOE-03 ALI 19067.1 EST HUMAN DKFZp7611130712Lrl 761 (synonym: hamy2) Homo sapiens cDNA clone DKFZp761130712 5' 4727 9839 14931 1.5 3.OOE-03 A1732754.1 EST-HUMAN ab18a08.x5 Stratagene lung (#937210) Horno sapiens cDNA'Clone IMAGE:841142 3'similar to contains Alu repetitive element; 5089 10187 15265 1.1 3.OOE-03 4506414 NT Homo sapions RAPI, GTPase activating protein 1 (RAP1 GA1) mRNA 5089 10187 15266 1,1 3.OOE-03 4506414 NT Homo sapiens RAPI, GTPase activating protein 1 (RAP1GA1) mRNA 504 5668 10790 0,9 2.0OE-03 Q04652 SWISSPROT RING CANAL PROTEIN (KELCH PROTEIN) 504 5668 10791 0.9 2.OOE-03 Q04652 SWISSPROT RING CANAL PROTEIN (KELCH PROTEIN) 768 7899 2,4 2.OOE-03 T70874.1 EST_HUMAN yd15h03xl Scares fetal liver spleen INFLS Homo sapiens cIDNA done IMAGE:1 083415' 1340 6468 11636 0.7 2.OOE-03 M20783.1 NT Human alpha-2-plasmin inhibitor gene, exons 6 and 7 1343 6471 11638 0.6 2.OOE-03 AA6616055 EST-HUMAN nu86f01.sl NCI_PGAP_Alvl Horno sapJens cDNA clone IMAGE:1 217593 1474 6601 11775 1.1 2.OOE-03 P48509 SWISSPROT PLATELET-ENDOTHELIAL TETRASPAN ANTIGEN 3 (PETA-3) (G1227) (MEMBRANE GLYCOPROTEIN SFA-1) (C13151 ANTIGEN) 1500 6626 11795 0.7 2.OOE-03 4557836 NT Homo saplens procollagen-lysine, 2-oxoglutarate 5-dioxygenase (lysine hydroxyiase, Ehiers Danlos syndrome type V$) (PLOD) mRNA 1500 6626 11796 0.7 2.OOE-03 4557836 NT Homo sapiens procollagen-lysine, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase, Ehiers Danios syndrome type V2 (PLOD) mRNA 1573 6699 1,8 2.00IE-03 P29400 SWISSPROT COLLAGEN ALPHA 5(1V) CHAIN PRECURSOR 1733 6856 12034 1.4 2.OOE-03 AA450138.1 ES-_HUMAN zx42a10xl Soares, total_fetus-Nb2HFkgw Homo sapiens cDNA done IMAGE:789114 5, 2203 7312 12524 1,0 2.OOE-03 AL163302.2 NT Homo sapiens chromosome 21 segment HS21 Cl 02 2535 7631 1.7 2.OOE-03 AW137782.1 ESI_HUMAN Ul-H-Bil-adi-9-10-0-Ul.sl NCI- CGAR._Sub3 Homo sapiens cONA done IMAGE:2717010 3' 3370 8513 13620 4.0 2.OOE-03 AA450138.1 EST-HUMAN zx42a10xl Soares_totai- fetu:_Nb2HF8_gw Horno saplens cIDNA done WAGE:789114 5, 3615 8754 13847 4.9 2.OOE-03 X87344.1 NT H.sapiens DMA, DMB, HLA21, IPP2, LMP2, TAP1, LIVIP7. TAP2, 008, DQB2 and RING8, 9, 13 and 14 genes 3869 9005 14104 2.OOE-03 AB040802.1 NT Rattus norvegidus mRNA for SREB1, complete ods 4024 9152 14235 2.2 2.OOE-03 P03374 SWISSPROT ENV P3LYPROTEIN 1CONTAINS: COAT PROTEIN GP52; COAT PROTEIN GP36) 4127 9253 9.8 2.OOE-03 U68491.1 NT Rattus norvegicus 5-hydroxytWtamine7 receptor gene, partial ods 4446 9566 14662 1.9 2.OOE-03 L42512.1 NT Drosophila melanogaster shortsighted class 2 IsLhs) mRNA, mplete ods 4446 9566 14663 1.9 2.OOE-03 L42512.1 NT Drosophila molanogaster shortsighted class 2 (shs) mRNA, complete ods 4608 9722 14817 0.9_ 2.OOE-03 AF223391.1 NT Horno saplens calcium channel alphal E subunit (CACNA1 E) gene, exons 7-49, and partial cds, alternatively spliced 4612 9726 1.7 2.OOE-03 R87773.1 ESTJHUMAN yo45c02.sl Soares adult brain N2b41-IBS5Y Horno sapiens cDNA clone 1MAGE180890 3' 5077 10 75 0.8 2.OOE-03 AJ245167.1 NT Camelus dromedarius cvhpl g gene for Immunoglobulin heavy chain variable region 386 5555 1.1 1.0OE-03 BE388904.1 EST_HUMAN 601284694F1 NIH_MGC 44 Homo sapiens cDNA done IMAGE:360 70 5' 432 5999 107301 1.4 1.0012-03 H96471.1 IEST HUMAN yt9M8.rl Soare!jIneal_gland N3HPG Homo sapiens cIDNA done IMAGE:232334 5' c ir Page 59 of 196 Table 4

2 Page 60 of 196 812 5962 11119 0,8_ 1.OOE-03 A1720263.1 EST HUMAN as70b08.xl Barstead colon HPI-RI37 Homo sapiens cDNA done IMAGE:2334039 3 similar to TR:Q13825 Q13825 AU-BINDING PROTEINIENOYL-COA HYDRATASE.; 812 5962 11120 0.8 1.OOE-03 A1720263.1 EST HUMAN as70b08.xl Barstead colon HPI-RI37 Homo sapiens cIDNA done IMAGE:2334039 Ysimilar to TR:Q13826 Q13825 AU-BINDING PROTEINIENOYL-COA HYDRATASE.; 1079 6217 11368 0.7 1.0012-03 A1865788.1 EST HUMAN wk86a06.xl NCI_PGAP_Panl Homo saplens cDNA done IMAGE:2422258 3' 1099 6237 11389 1.4 1.OOE-03 A1954572.1 EST HUMAN wx93e10.xl NCI CGA Me115 Homo sapiens cIDNA done iMAGE:2551242 3' 1150 6285 11438 1.5 1.OOE-03 A1692616.1 EST HUMAN wd86a01.xl NCI CGAP_Lu24 Homo saplens cDNA done IMAGE:2338440 Ysimilar to contains Alu repidtive element; 1982 7097 12300 1.3 1.OOE-03 P47808 SWISSPROT HIGH MOLECULAR WEIGHT FORM OF MYOSIN 1 (HMWMI 2108 7219 -12428 2.9 1.OOE-03 AJ131016.1 NT Homo saplens SCL gene locus 2951 8102 13208 1.2 1.OOE-03 AB033117.1 NT Homo saplens mRNA for K1AA1 291 protein, partial ods_ 3154 8303 13411 2.3 11.0OE-03 P18915 SWISSPROT CARBONIC ANHYDRASE VI PRECURSOR (CARBONATE DEHYDRATASE VI) (CA-VI) (SECRETED CARBONIC ANHYDRASE) (SALIVARY CARBONIC ANHYDRASE) 3154 8303 13412 2.3 1.OOE-03 P18915 SWISSPROT CARBONIC ANHYDRASE V1 PRECURSOR (CARBONATE DEHYDRATASE VI) (CA-VI) (SECRETED CARBONIC ANHYDRASE) (SALIVARY CARBONIC ANHYDRASE) 3262 8409 13516 1.2 1.OOE-03 P08547 SWISSPROT LINE-1 REVERSE TRANSCRIPTASE HOMOLOG 3496 8638 13750 0.8 1.OOE-03 U68061.1 NT Human MUC2 gene, Rromotee region 3496 8638 13751 0.8 1.0OE-03 U68061.1 NT Human MUC2 gene, promoter region 3855 8991 14091 1.0 1.OOE-03 Z49649.1 NT S.cerevislae chromosome X reading frame ORF YJR149w 4377 9499 14586 3.8 1.OOE-03 BE246536.1 EST HUMAN TWAP1 D4909 Pediatric pre-B cell acute lymphoblastc leukernia Bayfor-HGSC project=TCBA Homo sapiens cIDNA done TCBAP4909 4564 9682 14776 0.9 1.OOE-03 U29449.1 NT Caenorhabdids elegans spliced leader RNA (SL3 alpha), (S1-4), and (S1-5) genes 4717 9829 14920 1.8 1.OOE-03 A1073485.1 EST HUMAN ov45c04.xl Soares_testis NHT Homo sapiens cDNA done IMAGE:1640262 3' 4717 9829 14921 1.8 1.OOE-03 A1073485.1 EST HUMAN ov45c04.xl Soares_testis_NI-IT Homo sapiens cIDNA done IMAGE:1640262 3 4718 9830 6.2 1.OOE-03 BE154067.1 EST HUMAN PMO-HT0339-200400-010-DO2 HT0339 Homo sapiens cDNA 5009 10111 15181 17.0 1.OOE-03 046409 SWISSPROT APOLIPOPROTEIN A-IV PRECURSOR (AP -AIV) 1453 6580 11754 1.0 9.OOE-04 AW453046.1 EST HUMAN Ul-H-BW1-ama-e-03-0-Ul. sl NCI_QGAP-SW Homo sapiens cIDNA done IMAGE:3069388 Y 5131 10226 15301 0.8 9.OOE-04 L11910.1 NT Human refinoblastoma susceptibility gene exons 1-27, complete cds 1472 6599 1.4 8.OOE-04 X96469.1 NT X.laevis mRNA for C4SR protein 3843 8979 14080 1,3 8.OOE-04 R07008.1 EST HUMAN yf12h10xl Soares fetal liver spleen INFI.S Homo sapiens cDNA done IMAGE:126691 5' 4089 9215 4.2 8.OOE-04 P08547 SWISSPROT LINE-1 REVERSE TRANSCRIPTASE HOMOLOG 4656 9768 14864 2.4 8.OOE-04 U29185.1 NT Homo, sapiens prion protein (PrP) gene, complete ods 1786 6906 12094 0.6 7.OOE-04 L41825.1 NT Homo sapiens CYP17 gene, 5' end 2350 7452 12659 1.1 7.OOE-04 U29185.1 NT Homo, saplens prion protein CPrP) gene, complete ods 2682 7769 12969 3.3 7.OOE-04 AL163210.2 NT Homo sapiens chromosome 21 segment HS21 C01 0 3243 8390 13497 1.0 7.OOE-04 4885170 NT Homo saplens chromosome X open readingframe 6 (CXORF6) mRNA 967 6112 11268 1.6 6.OOE-04 P07207 SWISSPROT NEUROGENIC LOCUS NOTCH PROTEIN PRECURSOR 967 6112 11269 1.6 6.OOE-04 P07207 SWISSPROT NEUROGENIC LOCUS NOTCH PROTEIN PRECURSOR 967 6112 11270 1.6 6.OOE-04 P07207 SWISSPROT NEUROGENIC LOCUS NOTCH PROTEIN PRECURSOR Table 4

3877 9013 14108 1.3 6.OOE-04 A1862525.1 EST HUMAN v415al 1.xl NCI CGAP KJdl2.Homo saplens cDNA done IMAGE:2402876 3' 3999 9130 14212 0,9 6.OOEMK01315.1 NT Homo sapiens epsilon-l_ pseudogene fiGHEP1) gene, T flanking region 3999 9130 14213 0.9 6.OOE-04 K01315.1 NT Homo sapiens epsilon-1 pseudogene (IGHEP1) gene, Wflanking region 4092 9218 14301 -3.3 6.OOE-04 U45983.11 NT Homo sapiens CCR8 chemokine receptor (CIVIKBR8) gene, complete cds 635 5794 10917 2.0 5.OOE-04 010341 SWISSPROT HYPOTHETICAL 29.3 KID PROTEIN (ORF92) 1485 6612 0.7 5.OOE-04 AW851844.1 EST HUMAN OVO-CTO225-02109"30-a07 CT0225 Homo sapiens cIDNA nk27ell.sl NCI_PGAP_Coll HomosapienscIDNAdone IMAGE: 1014764 31 similar to 3367 8510 13617 1,4 5.OOE-04 AA548931,1 EST HUMAN contains AW repetitive element; 657 5814 10942 1.4 4.OOE-04 U32748.1 NT Haemophilus influenzae Rd section 63 of 163 of the complete genome as70b08.xl Barstead colon HPLIR137 Horno sapiens cIDNA. done IMAGE:2334039 Ysimilar 829 5978 11138 0.5 4.OOE-04 A1720263.1 EST HUMAN toTR:Q13825Q13825AU- BINDINGPROTEINIENOYL-COAHYDRATASE.; as701J08.xl Barstead colon HPILRI37 Horno sapiens. cIDNA done IMAGE:2334039 Ysimilar 829 5978 11139 0.5 4.OOE-04 A1720263.1 EST HUMAN to TR:1513825 Q13825 AU- BINDING PROTIZINIENOYL-COA HYDRATASE.

1449 6576 11750 1.4 4.00IE-04 AW753356.1 EST-HUMAN RC3-CT0254-130100023401 CT0254 Homo sapiens cIDNA 2037 7150 12355 0.6 4.OOE-04 A1-163278.2 NT Horno sapiens chromosome 21 segment HS21C078 DKFZp434D05_rl 434 (synonym: htes3) Homo sapiens cIDNA done DKFZp434DO59 5' 2086 7198 1,2 4.00IE-04 AL046704.1 EST HUMAN 2586 7679 12880 1.0 4.OOE-04 096615 SWISSPROT SERICIN-2 (SILK GUM PROTEIN 2) 8154 13254 0.8 4.OOE-04 P19474 SWISSPROT 52 KID RO PROTEIN (SJOGREN SYNDROME TYPE A ANTIGEN (SS-A)) (RO(SS-A)i) 3002 nh10a110.si NCI - CGAP_Col Homo sapiens'cDNA done IMAGE:951930 3'sImilar to 4228 9352 14432 2.8 4.OOE-04 AA576331.1 EST HUMAN gb:M21121 T-CELL SPECIFIC RANTES PROTEIN PRECURSOR (HUMAN); nhlOaIO.sl NCI C_Col Horno sapiens cIDNA done IMAGE:951930 Ysimilar to 14433 2,8 4.OOE-04 AA576331.1 EST_HUMAN gb:M21121 T-CELL SPECIFIC RANTES PROTEIN PRECURSOR (HUMAN); 4228 9352 14653 1.3 4.OOE-04 AA086324.1 EST HUMAN zn61 c08.sl Stratagene muscle 937209 Homo sapiens cDNA done IMAGE:562670 3' 4437 9558 yy78bl 0.sl Scares_muldplMderosi!_2NbHMSP Homo sapiens cIDNA done 5132 10227 15302 0.9 4.0012-04 N48313.1 EST HUMAN IMAGE:279643 Y similar to contains Alu repetitive element; DI(FZp7611 J221-rl 761 (synonym: hamy2) Homo sapiens c1DNA done DKFZp761 J221 5, 5346 10474 1.0 3.OOE-04 AL1 19426.1 EST_HUMAN 188 5382 10509 0.8 3.OOE-04 P49259 SWISSPROT 180 KID SECRETORY PHOSPHOLiPASE A2 RECEPTOR PRECURSOR (PLA2-R) 862 6010 11171 1.3 3.00IE-04 U83991.1 NT Human short chain acyl CoA dehydrogenase gene, exons 1 and 2 3.OOE-04 A1399674.1 EST HUMAN th23a02.xl NCI WAP_Pr28 Homo saplens cDNA done IMAGE:2119082 3' 1810 6929 1.2 3268 8414 13520 3.4 3.OOE-04 P25147 SWISSPROT INTERNALIN B PRECURSOR 3882 9018 14113 3.6 3.OOE-04 P49448 SWISSPROT GLUTAMATE DEHYDROGENASE 2 PRECURSOR (GIDH) 3969 9101 1.2 3.OOE-04 AJ271735.1 NT Homo sapiens Xq pseudoautosomal region; segment 112 Homo sapiens transcription factor IGHM enhancer 3, JMI1 protein, JM4 protein, JIVIS protein, T54 protein, JM10 protein, A4 differentiation-dependent protein, triple LIM domain protein 6, and synaptophysin genes, complete ods; and L-type calcium channel a> 3991 9123 14207 1,1 3.00IE-04 AF196779.1 NT 4711 9823 4.5 3.00IE-04 BE153778.1 EST HUMAN PMOW-M 9-190200-007-912 HT0339 Homo saplens cDNA 4784 9895 14988 0.9 3.00IE-04 AW937723.1 EST HUMAN QV3-UT 5.221299-046- d09 DT0045 Horno saplens cDNA 5052 1015112 1.3 3.OOE-04 Y1 1204.1 NT V.carted gene encoding volvoxopsin Page 61 of 196 Table 4

169 5363 10489 1,2 2.OOE-04 AF217796.1 NT Horno sapiens SCG10 likeprotein, helicase-like protein NHL, M68, and ADP-dbosyladon factor related protein 1 (ARFRP1) genes, complete ods 889 6037 11195 1.5 2.OOE-04 M86524.1 NT Human dystrophin gene 889 6037 11196 1.5 2.OOE-04 M86524.11 NT Human dystrophin gene 1162 6297 1.4 2.0012-04 A1286021.1 EST HUMAN qh98el 1.xl Soares_NFL-T- G13C-SI1 Homo sapiens cDNA clone IMAGE:1855052 Ysimilar to contains MER312 MER3 repetitive element; 1169 6303 0.7 2.OOE-04 AL1 63203.2 NT Homo sapiens chromosome.21 segment HS21 C003 1791 6911 0.5 2.OOE-04 AF224268.1 NT Mus musculus 5'flanking region of P1W gene 2136 7246 1.3 2.OOE-04 AA478980.1 EST HUMAN zu39b05.sli Soares ovary tumor NbHOT Horno sapiens cDNA cJone IMAGE:740337 Ysimilar to contains Alu repetitive element; 2528 7624 12825 1.5 2.OOE-04 U66061.1 NT Human germline T-cell receptor beta chain TCRBV17S1A1T, TCR13V2S1, TCRI3VIOS1P, TCR13V29S1P, TCIRW19S1P, TCR13V15S11, TCRBV11S1AIT, HVI3 relic, TCR13V28S1P, TCRI3V34S11, TCIRBV14S1, TCRI3V3S1, TCRI3V4S1A1IT, TRY4, TRY5, TRY6, TRY7, TRY8, TCRI3D1, TCR13.111S1, TCR13,11S2,> 2958 8109 13215 1.0 2.OOE-04 AI 124529.1 EST-HUMAN am5M9.xl Johnston frontal cortex Horno sapiens cDNA done IMAGE: 1539760 3, 3389 8532 13637 2.5 2.OOE-04 BE082317.1 EST HUMAN QV2-BT0636-070500.194- b07 BT0636 Horno sapiens cIDNA 3417 8559 13670 1.0 2.OOE-04 U34374.11 NT Human tyrosine kinase TXK (tKk) gene, exons 9 and 10 3837 8973 14073 0.8 2.OOE-04 AW978441.1 EST HUMAN EST390550 MAGE resequences, MAGP Horno saplens cDNA 4051 9178 4.6 2.OOE-04 U01029.1 NT Phaseolus vulgarls nitrate reductase (PVNR2) gene, complete cds 4569 9687 14781 1.3 2.OOE-04 H96265.1 EST HUMAN yuOlel 1.rl Soares_pineaLgiand N3HPG Horno sapiens cDNA done IMAGE:232556 5' 4569 9687 14782 1.3 2.OOE-04 H96265.1 EST HUMAN yu01 el 1xl Soares_plneal_gland N3HPG Homo sapiens cDNA done IMAGE:232556 5' 4689 9801 1.3 2.OOE-04 U09226.1 NT Gallus gallus proteasome 28 kDa subunit homolog mRNA, complete cds 4946 10051 15122 1.3 2.OOE-04 Q99297 SWISSPROT PUTATIVE MITOCHONDRIAL CARRIER YOR222W 4991 10094 15162 1.7 2.OOE-04 A13037997.1 NT Danio redo hagoromo gene, exons 1 to 6, partial cds 750 5902 11048 1.0 1.0OE-04 H99646.1 EST-HUMAN yx26c09.sl Soares melanocyte 2NbHM Homo sapiens cDNA eJone IMAGE:262864 3'similar to contains Li.tl L1 repetitive element; 1059 6198 11351 0.8 1.0012-04 P1 1369 SWISSPROT RETROVIRUS-RELATED P.OL POLYPROTEIN (CONTAINS: REVERSE TRANSCRIPTASE ENDONUCLEASE) 1098 6236 11387 1.3 1.0OE-04 AW013847.1 EST-HUMAN Ul-H-BIO-aab-e-09-0-Ul, sl NCLWAP-Subl Homo sapiens cIDNA done IMAGE:2708825 3' 1098 6236 11388 1.3 1.OOE-04 AW013847.1 EST HUMAN Ul-H-BIO-aab-e-09-0-Ul. sl NCI CGAP_Subl Homo sapiens cDNA done IMAGE:2708825 3' 1310 6438 1.0 1.OOE-04 U62918.1 NT Anguilia angul la dopamine D1A1 receptor (d1A1) gene, complete cds 1610 6737 11906 1.2 1.OOE-04 AF148805.1 NT Kaposi's sarcoma-associated berpesvirus ORF 68 gene, partial cds; and ORF 69, kaposin, v FLIP, v-cyclin, latent nuclear antigen, ORF K14, v-GPCR, putative phosphodbosyifonnyigiycinamidine synthase, and LAMP (LAMP) genes, complete cds 1610 6737 11907 1.2 1.OOE-04 AF148805.1 NT Kaposi's sarcoma-associated herpesvirus ORF 68 gene, partial cds; and ORF 69, kaposin, v FLIP, v-cycJin, latent nuclear antigen, ORF K14, v-GPC1R, putative phosphodbosylformylglycinamidine synthase, and LAMP (LAMP) genes, complete cds 600 7691 12895 1.3 1.OOE-04 AA714263.1 EST HUMAN nv95a02.sl NCI_PGAP Pr16 Homo sapiens cDNA eJone IMAGE: 1237514 similar to contains Alu repetitive element; Page 62 of 196 Table 4

* 2600 7691 12896 1.3 1.OOE-04 AA714263.1 EST-HUMAN nv95a02.sl NCLCGAP_Prl6Homosapiens cDNA done IMAGE:1237514 similar to contains Alu repetitive element; 2655 7744 12943 1.2 1.0OE-04 BE218833.1 EST-HUMAN hv45c08.xl NCI CGAP_Lu24 Homo saplens cDNA done IMAGE:3176366 3' 2655 7744 12944 1.2 1.OOE-04 BE218833.1 EST-HUMAN hv45c08.xl NCIjWAP Lu24 Horno sapiens cDNA done IMAGE:3176366 3' 3247 8394 13501 1.0 1.0OE-04 Q62203 SWISSPROT SPLICEOSOME ASSOCIATED PROTEIN 62 (SAP 62) (SPLICING FACTOR 3A SUBUNIT 2) (S173A66) 3675 8814 13908 1.1 1.OOE-04 A1440282.1 EST-HUMAN 401 fl 1.xl INICk_WAP_Gas4 Horno sapiens cDNA done IMAGE:2140269 3' similar to contains AW repetitive element; 3971 9103 14186 1.8 11.0OE-04 M14042.1 NT Mouse;ipha 1 type-IV collagen mRNA 4362 9484 14575 0.9 1.0OE-04 P08547 SWISSPROT LINE-1 REVERSE TRANSCRIPTASE HOMOLOG 4665 9777 14874 3.0 1.OOE-04 015117 SWISSPROT FYN-BINDiNG PROTEIN (SILP- 76 ASSOCIATED PROTEIN) (SLAP-130) 5028 10129 15203 1.6 1.OOE-04 7662015 NT Homo sapiens KIAA0237 gene product (K1AA0237), mRNA 5028 10129 15204 1.6 1.OOE-04 7662015 NT Homo saplens KIAA0237 gene product (KiAA0237), mRNA 5033 10133 15208 1.0 1.0OE-04 A1357156.1 EST-HUMAN qx62h04.xl Cl_WAP GC4 Homo saplens cDNA done IMAGE:2005975 3' 5148 10243 0.9 1.OOE-04 Z72560.1 NT S.cerevislae chromosome VIl reading frame ORF YGL038c 683 5838 10971 0.6 9.OOE-05 AA718933.1 EST-HUMAN ah45cl I.sl Soares tesgs_NHT Homo sapiens cDNA done 1292468 3' 1589 6715 11885 1A 9.OOE-05 AL04381 0.1 EST-HUMAN WZp434A0l2Qj11 434 (synonym: htes3) Homo sapiens cDNA done DK17Zp434A0128 5' 3995 9127 14210 0.8 9.OOE-05 A1762209.1 EST-HUMAN YA54cl 1.xl NCI_PGAP_Col 6 Homo saplens cDNA done IMAGE:2394068 Ysimilar to contains MER6M MER6 repetitive element, 804 5955 11108 1.5 8.OOE-05 AJ251646.1 NT Pisum sativum mRNA for beta-11, 3 glucanase (gns2 gene) 846 5995 1.2 13.0OE-05 AJ251646,1 NT Pisum sativum mRNA for beta-1,3 glucanase (gns2 gene) 2920 8071 0.8 8.OOE-05 M83575.1 NT Human platelet-derived growth factor A chain (PDGFA) gene, exons only 4852 9959 1.2 8.OOE-05 F28172.11 EST HUMAN HSPD16734 HM3 Homo saplens cDNA done s3000003H04 344 5525 10650 1.0 7.OOE-05 AW847445.1 EST HUMAN IRC3-CT0208-220999-01 1- E04 CT0208 Homo saplens cONA 344 5525 10651 1.0 7.OOE-05 AW847445.1 EST HUMAN RC3-CTO208-220999-01 I- E04 CTO208 Horno, sapiens cDNA 555 5718 10834 1.1 7.OOE-05 L49075.1 EST HUMAN HUM072014F Human fovea cDNA Homo saplens cDNA done EST HF0072014 555 5718 10835 1.1 7.OOE-05 L49075.1 EST-HUMAN HUM072014F Human fovea cDNA Horno saplens cDNA done EST HFD072014 1039 6179 11332 0.8 7.OOE-05 Q22949 SWISSPROT PROBABLE GLYCEROL-3- PHOSPHATE ACYLTRANSFERASE, MITOCHONDRIAL PRECURSOR(WAT) 1083 8221 11372 0.7 7.OOE-05 T05902.1 EST HUMAN EST03791 Fetal brain, Stratagene (cat#936206) Homo sapiens eDNA done HFBD136 2686 7773 12972 1.9 7.OOE-05 AL1 63278.2 NT Homo sapiens chromosome 21 segment HS21 C078 3121 8270 13375 5.8 7.OOE-05 A13009080.1 NT Dictyostelium discoldeum gene for TRFA, complete cds 3475 8616 13728 1.1 7.OOE-05 AL163303.2 NT Homo saplens chromosome 21 segment HS21 Cl 03 4276 9401 14485 1.3 7.OOE-05 ALl 63201.2 NT Homo sapiens chromosome 21 segment HS21C001 4344 9467 14555 0.8 7.0012-05 U60980,1 NT Caenorhabdids elegans Skpl p homolog mRNA, complete ods 5202 10293 1.1 7.OOE-05 AA367612.1 EST - HUMAN EST78713 Placenta 1 Homo saplens cDNA 1981 7096 12298 0.6 6.OOE-05 4885170 NT Homo saplens chromosome SE open reading frame 6 (CXORF6) mRNA 1981 7096 12299 0.6 6.OOE-05 4885170 NT Homo sapiens chromosome X open reading frame 6 (CXORF6) mRNA E1 7640 12841 0.5 6.0012-05 A1655241.1 EST HUMAN _ wb54h06.xl NCLC GC6 Homo sapiens cDNA done IMAGE:2309531 Ysimilar to gb:J03250 DNA TOPO1i0MERASE 1 (HUMAN); Page 63 of 196 Table 4

2652 7741 12941 0,9 6.OOE-05 Z84506.1 NT H.sapiens flow-sorted chromo, some 6 Hindiii fragment, SC6pA281310 2652 7741 12942 0.9 6.OOE-05 Z84506.1 NT H.sapiens flow-sorted chromosome 6 Hindill fragment, SC6pA281310 2783 5820 10947 0.8 6.OOE-05 AF053630.1 NT Horno saffiens monoceutrophil elastase inhibitor gene, complete cds 1382 6509 11673 5.2 5.OOE-05 AW392086.1 EST HUMAN OV4-ST0234-241199-040- hl 1 ST0234 Homo sapiens cIDNA 1819 6938 0.6 5.0OE-05 8923891 NT Homo sapiens 22kDa peroxisomal membrane protein-like (LOC55895), mRNA 1 and 2831 7982 13082 0.9 5.OOE-05 A.1251058.1 NT exon Homo sapiens MEP1A gene, promoter region Homo saplens partial SLC22A3 gene for extraneuronal monoamine transporter (EMT), exon 1 3897 9032 14125 3.0 5.OOE-05 AJ251884.1 NT 2220 7327 1,4 4.OOE-05 AJ289880.11 NT Homo saple KIAA0851 gene (partial), XT3 gene and LZTFL1 gene 2776 5415 1.6 4.OOE-05 U112821.1 NT Human renin (REN) gene, C flanking region 4624 9738 14834 7,1 4.OOE-05 AL163280.2 NT Homo saplens chromosome 21 segment HS21 C080 qh64c10.xl SoareaLfetal - liver spleenjNFI.S - S1 Homo sapiens cIDNA done IMAGE:1849458 Ysimilar to contains Alu repetitive element;contalns element KER repetitive 665 5821 10949 0.8 3.OOE-05 A1248061.1 EST HUMAN element; AW273851.1 EST HUMAN xv24903.xl Soares NFL T G13Q_S1 Horno saplens cDNA done IMAGE:2814100 3' 1043 6183 11336 1.4 3.OOE-05 2688 7775 12974 0.9 3.OOE-05 Q62234 SWISSPROT SKELEMIN 4285 9410 14496 6.9 3.OOE-05 BE169211.1 EST HUMAN PM1-HT0521-120200-001- elo HT0521 Homo sapiens cIDNA 4285 9410 14497 6.9 3.OOE-05 BE169211.1 EST HUMAN PM1-HT0521-120200-001e1OHT0521HomosapienscDNA 14577 1.2 3.OOE-05 AA368679.1 EST-HUMAN EST79996 Placenta 1 Horno, sapiens cDNA similar to similar to p53-assoclated protein 4365 9487 14578 1.2 3.OOE-05 AA368679.1 EST HUMAN EST79996 Placenta 1 Homo sgpiens cDNA similar to similar to p53-assodated protein 4365 9487 14729 0.9 3.OOE-05- AF149773.1 NT Homo sa lens NOD1 protein (NOD1) gene, exons 1, 2, and 3 4519 9638 qh64c10.xl Scares - fetal liveLspleen-1 NFI.S_S1 Homo saplens cDNA clone IMAGE:1849458 Y similar to contains AW repetitive element;contalns element KER repetitive 4731 5821 10949 0.8 3.OOE-05 A1248061.1 EST HUMAN element; qh98e11.xl Soares_NFL,GBC_SI Horno saplens cIDNA done IMAGE:1855052 3' similar 2276 7382 12590 0.6 2.OOE-05 A1286021.1 EST HUMAN to contains MER312 MER3 repetitive element; 2538 7634 12834 1,1 2.OOE-05 M13792.1 NT Human adenosine deaminase (ADA) gene, complete cds zq46a12.rl Stratagene hNT neuron (#937233) Homo sapiens cDNA done IMAGE:632734 5' similar to contains Alu repetitive element;oontains element 1.1 repetitive element; 2681 7768 2,6 2.0OE-05 AA160562.1 EST HUMAN 3098 8249 13353 1.5 2.OOE-05 BE066036.1 EST HUMAN RC3-BT0319-120200-014- h08 BT0319 Homo sapiens ONA 3304 8449 13559 0.9 2.OOE-05 AF184614.1 NT Horno sapiens p47-phox (NCFI) gene, complete cds 3323 8467 13582 1,1 2.OOE-05 X8921 1.1 NT H.sapiens D for endogenous retroviral like element 3358 8501 13610 5.3 2.OOE-05 AL.163207.2 NT Homo saplen chromosome 21 segment HS21 C007 3449 8591 1.0 2.OOE-05 X95465.1 NT S.cerevislae 12.8 Kbp fragment of theleft arm of chromosome XV 3737 8874 0.9 2.OOE-05 AL039107.1 EST HUMAN DKRp5661064 rl 566 (synonym: hfkd2) Homo sapiens cIDNA done 13KFZp5661064 S' qq13a08.xl Soares_NhHMPu-Sl Homo saplens cDNA clone IMAGE:1932374 3' similar to 4510 9629 14723 1.0 2.OOE-05 A1263349.1 EST HUMAN contains MER1813 MER18 repetitive element; 4592 9706 1.1 2.OOE-05 BE378471.1 EST HUMAN 601236455F1 N1H MGC 44 Homo saplens cDNA done IMAGE:3608653 5' 4782 9892 14985 0.8 2.OOE-05 AJ 131016.1 NT Homo sapiens SCL Cone locus 2663 7951 12949 0.6 1.OOE-05 AL-163282.2 NT orno saplens chromosome 21 segment HS21 C082 Page 64 of 196 Table 4

3238 8385 13493 0.9 1.OOE-05 AA631 101.1 EST HUMAN nq77g06.si NCI CGAP Pr22 HOMO saplens cDNA done IMAGE: 1158394 3' 3599 8738 13833 1.7 1.OOE-05 AF088273.1 NT Drosophila melanogaster strain Larnto 120 Suppressor of Hairless (Su(H)) gene, partial ods 3686 9022 14115 9.2 1.0OE-05 P81274 SWISSPROT MOSAIC PROTEIN LGN 4082 9209 14293 1. 1 1.OOE-05 AL1 63203.2 NT Homo sapiens chromosome 21 segment HS21 C003 4180 9306 14385 2.0 1.OOE-05 AA431119.1 EST HUMAN zw69g04xl Scares testis NHT Homo saplens cDNA done IMAGE:781494 5' 4742 9853 14945 2.2 1,OOE-05 AW419134.1 EST HUMAN xy49g11 1.xl NCI CGAP Lu34.1 Homo sapiens cDNA done IMAGE:2856548 3' 4882 9990 1W71 4,5 1.OOE-05 AL163246.2 NT Homo sapiens chromosome 21 segment HS21 C046 2637 7726 12930 2.4 9.OOE-06 A158381 1.1 EST HUMAN W3a06.xl NCI 2246386 3' ---PGAPHSC3 Homo saplens cDNA done IMAGE:

3057 8208 13307 3.7 9.OOE-06 A1218983.1 EST-HUMAN q91 1 b08.xl Soares_piacenta-8togweeki_2NbHP8togW Homo saplens cDNA done IMAGE:1759191 3' 3559 8698 2.9 9.OOE-06 M61755.1 NT Human alanine:giyqxylate aminotransferase (AGXT) gene, exons 1 and 2 2483 7944 12783 0.6 8.OOE-06 AW362539.1 EST HUMAN RC21-CT0283-201199-011- h111 CT0283 Homosapiens cDNA 963 6108 0.6 7.OOE-06 AA669729.1 EST HUMAN abgOfIO.sl Stratagene lung (#937210) Homo, saplens cDNA done IMAGE:854251 3'sImilar to contains MER20.1:1 MER20 repetitive element; 1420 6548 11723 1,2 7.OOE-06 7662177 NT Homo saplens K1AA0555 gene product (K1AA0555), mRNA 2844 7995 6.7 7.OOE-06 A1368252.1 EST HUMAN qw16g09.xl NCI - CGAP_Ut3 Homo sapiens cDNA done IMAGE:1991296 Ysimilar to contains Alu repetitive element; 3516 8657 0.9 7.OOE-06 AA385542.1 EST HUMAN EST99205 Thyroid Homo saplens cDNA Wend similar to EST containing L1 repeat 2887 8038 13139 1.1 6.OOE-06 BE069189.11 EST HUMAN CIV3-13T037"11 0300- 105-0 1 BT0379 Homo sapiens cDNA 3635 8774 13868 1.0 6.OOE-06 SE069189.1 EST-HUMAN. OV3-BT0379-010300-105. dl 1 BT0379 Homo saplens cDNA 4647 8062 13169 1.8 6.OOE-06 001456 SWISSPROT OVARIAN ABUNDANT MESSAGE PROTEIN (OAM PROTEIN) 4653 9765 14860 2.0 6.OOE-06 A1040099.1 EST-HUMAN ox013e02.xl Soare_fetaUiveLspleen 1 NKS---SI Homo saplens cDNA done IMAGE:1 655738 Ysimilar to containsiER8.t2 MER8 repetitive element; 631 5790 10912 1.5 4.OOE-06 R1 6267.1 EST-HUMAN ya48c03xl Soares Infant brain 1MB Homo, saplens cDNA done IMAGE:53254 Tsimilar to contains Alu repetitive elementcontains L1 repetitive element; 828 5977 11137 3,2 4.OOE-06 AW103354.1 EST HUMAN xc69g12.xl NCI - CGAP_Eso2 Horno sapiens cDNA done IMAGE:2589574 3'similar to contains Alu repetitive element;contains element MER21 repetitive element; 1312 6440 11606 1.8 4.OOE-06 A11334928.1 EST HUMAN tb33e09.xl NCI CGAP_HSC2 Homo sapiens cDNA done IMAGE:2056168 3' 1312 6440 11607 1.8 4.OOE-06 A1334928.1 EST HUMAN th33e09.xl NCI CGAE HSC2 Homo sapiens cDNA done IMAGE:2056168 3' 1329 6458 2.4 4.OOE-06 X87344.1 NT H.saplens DMA, DMB, HLA211, IPP2, LMP2, TAP1, LMP7, TAP2, DOB, DQB2 and RING8, 9, 13 and 14 genes_ 2218 7326 12540 1.2 4.OOE-06 AW015401.1 EST-HUMAN Ul-H-BIO-aat-f-05-0-Ul. sl NCI-CGAP-Subl Horno sapiens cDNA done IMAGE:2710425 3' 3025 8177 13278 1.4 4.OOE-06 AF198349.1 NT Gallus gallus Dach2 protein (Dach2) mRNA, complete cds 3500 8642 0.9 4.OOE-06 H92947.11 EST-HUMAN yt94cl 1.sl Soares_plneai_gianO_N3HPG Homo sapiens cIDNA done IMAGE:231956 3' similar to contains LOR1 repetitive element; F-3819 8956 14052 1.8 4.OOE-06 AW848295.1 EST HUMAN IL3.CTO214.15020M74803 CT0214 Homo Fapiens cDNA 4702 9814 14910 1.6 4.OOE-06 A1886939.1 EST HUMAN v094c10.xl NCI_CGAF_8m25Homosapiens eDNA done IMAGE:2432562 simarto contains element MER22 repetitive element:

4 9947 15036 1.0 4.OOE-06 AL163279.2 NT Homo sapiens chromosome 21 segment HS21 C079 Page 65 of 196 Table 4

2117 7228 12436 1.3 3.OOE-06 AA700562.1 EST HUMAN z134b08.sl-Soares-fetalliveLspleen " iNFLS - S1 Homo sapiens cDNA done IMAGE:432663 Ysimilar to contains Ll.tl 1.1 repebb;e element; 2117 7228 12437 1.3 3.OOE-06 AA700562.1 EST HUMAN A34b08.sl Soares - fetal liveLspleerLlNFLS_Sl Horno sapiens cDNA done IMAGE:432663 3' similar to contains L1 11 L1 repetitive element; 2891 8042 13142 1.0 3.OOE-06 AA868218.1 EST-HUMAN ak48g11 1.sl Soares_pstis NHT Homo sapiens cDNA done IMAGE. 1409252 Ysimilar to contains LTR1.t3 LTR1 reefitive element 3228 8376 2.1 3.OOE-06 A1857779.1 EST-HUMAN YA22a05.xl NCLCGAP_Utl Honno sapiens cDNA done IMAGE:2425616 3'stmilar to TR:060734 060734 LINE-1 LIKE PROTEIN xontains LIA2 1.1 repetitive element; 3716 8853 13944 1.3 3.OOE-06 BE047094.1 EST HUMAN hq64d112.xl NCI_PGA12 HN13 Horno sapiens d3NA clone IMAGE:3124151 3, 3716 8853 13945 1.3 3.OOE-06 BE047094.1 EST-HUMAN hq64d12.xlINCI. GAp_lrIN113 Horno saplens cDNA done IMAGE:3124151 3' 4376 9498 14585 0.9 3.OOE-06 T50266.1 EST-HUMAN yb78b1O.rl Stratagene ovary (#937217) Horno saplens cDNA clone IMAGE:77275 Csirnliar to contains L1 repetitive element 4461 9581 14678 4.3 3.OOE-06 X54816.1 NT Homo saplens gene for alpha-1microglobulin-bikunin, exons 1-5 (encoding alpha-l microglobulin, N-termInus.) 5389 1.1 2.OOE-06 P54366 SWISSPROT HOMEOBOX PROTEIN GOOSECOID 1550 6677 2.3 2.OOE-06 P21414 SWISSPROT POL POLYPROTEIN [CONTAINS: PROTEASE; REVERSE TRANSCRIPTASE; ENDONUCLEASE) 2326 7429 12638 1.1 2.OOE-06 A1672138.1 EST-HUMAN waO4a03.xl NCI- CGAP_KJdl 1 Horno sapiens cDNA clone IMAGE:2297068 3'similar to contains MER30.1J11 MER30 repetitive element; 2418 7517 12724 0.8 2.OOE-06 04929 SWISSPROT HiSTIDINE-RICH GLYCOPROTEIN PRECURSOR 2519 7615 12817 2.7 2.0012-06 P06719 SWISSPROT KNOB-ASSOCIATED HISTIDINE- RICH PROTEIN PRECURSOR (KAHRP) 3700 8839 13930 1.5 2.OOE-06 AA173518.1 EST HUMAN zp02e05xl Stratagene ovarian cancer (#937219) Horno saplens oDNA done IMAGE:595232 5' 3710 8848 13938 1.5 2.OOE-06 AB030896.1 NT Mus musculus gene for odorant receptor A1 6, complete ods 31 5240 10345 0,7 1.OOE-06 076082 SWiSSPROT ORGANIC CATIONICARNITINE TRANSPORTER 2 (SOLUTE CARRIER FAMILY 22, MEMBER 5) (HIGH-AFFINITY SODIUM-DEPENDENT CARNITINE COTRANSPORTER) 641 5800 10926 0.6 1.0012-06 AF084364.1 NT Mus musculus D6MM5E protein (D6MmSe) mRNA, complete cds 1041 6181 1.0 1.OOE-06 A1206097.1 EST HUMAN qg28b09.xl NCI WAP-KW Homo saplens cDNA done IMAGE:1762361 Ysimilar to TR413538 013538 ORF2: FUNCTION UNKNOWN.; 1435 6562 11738 0.8 1.OOE-06 P09125 SWISSPROT MEROZOITE SURFACE PROTEIN CMZ-8 1507 6634 11803 1.1 1.OOE-06 A1.163278.2 NT Homo saplens chromosome 21 segment H821 C078 1554 6681 11849 0.9 1.OOE-06 AA034141.1 EST HUMAN z106a12.sl Soares- fetaUiveUpleen_1NFLS-Sl Homo sapiens cDNA done IMAGE:429982 Ysimilar to contains Mu repetitive element 1554 6681 11850 0.9 1.0OE-06 AA034141.1 EST HUMAN z106a12.sl oares - fetaLliver-spicen-INFLS-Sl Homo sapiens cDNA done IMAGE:429982 Ysimilar to contains AM repetitive element 1565 6692 1.2 1.OOE-06 P27625 SWISSPROT DNA-DIRECTED RNA POLYMERASE Ill LARGEST SUBUNIT 1949 7066 12261 1.7 1.0OE-06 AF184614.1 NT Homo saplens p47-phox (NCFI) gene, complete ods 1949 7066 12262 1.7 1.OOE-06 AF184614.1 NT Horno sapiens p4ahox (NCF1) gene, complete cds 9398 14481 11.1 1.OOE-06 U07561.1 NT Human ABL gene, exon 1 b and Intron 1b, and putative M8604 Met protein (M8604 Met) gene, complete cds 10143 15220 1. 1.OOE-06 AL163285.2 NT Homo sapiens chromosome 21 segment HS21C085 Page 66 of 196 Table 4

5043 10143 15221 1.4 1.ooE-o6 AL163265.2 NT Homo sapJens chromosome 21 segment HS21C085 357 5536 10666 0.5 9.OOE-07 AF003529.1 NT Homo sapiens glypican 3 (GPC3) gene, partial ods and flanking repeat regions 357 5536 10667 0.5 9.OOE-07 AF003529.1 NT Homo sapiens glypican 3 (GPC3) gene, partial ods and flanking repeat regions 1034 6174 0,9 8.OOE-07 BE047871.1 EST-HUMAN tz43d06.yl NCI CGAP Bm52 Homo saplens cDNA done IMAGE:2291339 5' 3498 8640 1.4 8.OOE-07 BE047871.1 EST-HUMAN tz43d06.yll NCI CGAP Bm52 Homo saplens cDNA done IMAGE:2291339 5' 4661 9773 14868 4.5 8.OOE-07 A1288596.1 EST---HUMAN q182g07.xl Soares NhHMPu S1 Homo saplens cDNA clone IMAGE:1878876 3, 4661 9773 14869 4.5 8.OOE-07 A1288596,1 EST-HUMAN q182g07.xl Soares Nhi- IMPu S1 Homo sapiens cDNA done IMAGE:1878876 3' 1822 6941 12131 0.9 7.OOE-07 AF167341.1 NT Homo sapiens membrane intedeukin 1 receptor accessory protein (11-1 RA) gene, exons and 11 1870 6988 12173 0,9 6.OOE-07 AW855558.1 ESTHUMAN CM3-CTO277-221099-024-el 1 CTO277 Homo saplens cDNA 2442 7541 12749 0.9 6.OOE-07 AF019413.1 NT Homo saplens HLA class Ill region containing tenascin X (tenascin-X) gene, partial cds; cytochrome P450 21 -hydroxylase (CY1321 B), complement component C4 (C4B) G1 1, belicase (SK12W), RD, complement factor B (B0, and complement component C2 (C2) genes,> 3891 9027 1.7 6.OOE-07 P41479 SWISSPROT HYPOTHETICAL 24.1 KI) PROTEIN IN LEF4-P33 INTERGENIC REGION 323 5506 1.2 5.OOE-07 A1831893.1 EST HUMAN wh601 0.xl NCL9GAP_Kidl 1 Homo saplens cDNA clone IMAGE:2385547 3' 2995 8147 0.9 5.0012-07 A1831893.1 EST HUMAN wh601 0.xl NCI_jCGAP KAdl 1 Homo sapiens cDNA done IMAGE:2385547 3, 4547 9666 14755 1.4 5.OOE-07 AF149774.1 NT Homo sapiens NOD1 protein (N0D1) gene. exons 4 through 14 and complete cds 3916 9052 14140 2.0 4.OOE-07 AW009602.1 EST HUMAN ws84h05.xl NCI CGAp_po21 Homo saplens cDNA done IMAGE:2504697 3' 434 5601 10732 1.7 3.OOE-07 U19719.1 NT Human microflbdi-associated glycoprotein (MFAP2) gene. putative promoter region and alternatively spliced untranslated exons 568 5729 10846 0.8 3.OOE-07 A.1271735.1 NT Homo saRiens Xq pspudoautosomal region; segment 112 1352 6480 11646 0.8 3.OOE-07 M99149.11 NT Human polymorphic microsatellite DNA 1608 6735 0.8 3.0OE-07 M64857.1 NT Human lgK subgroup 1 germilne gene. exons 1 and 2. V-region 018 allele 2000 7115 1,0 3.0012-07 AA526763.1 EST HUMAN n156b09.si ISICI_PGAP---Ov2 Homo sapiens cDNA clone IMAGE:980625 similar to contains Alu reReUdve element;contains Ll.t3 L1 repetitive clement; 7348 12558 1.2 3.OOE-07 M99149.1 NT Human polymorphic microsatellite DNA 2420 7519 12726 6.2 3.OOE-07 BE005077.1 EST-HUMAN MRO-BN01 15-020300- 001411 BN01 15 Homo sapiens cDNA 2420 7519 12727 6.2 3.OOE-07 BE005077.1 EST-HUMAN MRO-BN01 1 5-020300-001- fl 1 BN01 15 Horno sapiens cDNA 2998 8150 13250 0.9 3.OOE-07 TB4704.1 EST_HUMAN ydSOfl 2xl Soares fetal liver spleen 1 NFLS Homo sapiens cDNA clone IMAGE:1 11695 V 3122 8271 13376 1.8 3.OOE-07 P38739 SWISSPROT WO-T-HETICAL 63.8 KI) PROTEIN IN GUTI-RIM1 INTERGENIC REGION PRECURSOR 4195 9321 14406 2.4 3.OOE-07 AF044206.1 NT Homo sapiens cyd2Menase LCOX- 2) gene, promoter and exon 1 4195 9321 14407 2.4 3.OOE-07 AF044206.1 NT Homo sapil ns cycfooxygenase (COX-2) gene, promoter and exon 1 4364 9486 14576 0.9 3.OOE-07 Q10364 SWISSPROT PUTATIVE SERINE/THREONINE- PROTEIN KINASE C22E12,14C 4654 9766 14861 0.9 3.OOE-07 A1797236.1 EST HUMA we86b12.xl Soares NFL T GBC S1 Homo saelons cDNA done IMAGE:2347967 3' 4996 10099 15166 1.5 3.OOE-07 T57850.1 EST-HUMAN ycl4hO9.si Stratagene lung (#937210) Horno sapiens cONA done IMAGE:80705 Ysimilar to ar to gbM62982 ARACHIDONATE 12-LIPOXYGENASE (HUMAN) 4996 10099 15167 1.5 3.OOE-07 T57850.1 EST HUMAN ycl4h09.al Stratagene lung (#937210) Horno sapiens cDNA done IMAGE:80705 X similar to similar to gb:M62982 ARACHIDONATE 12-LIPOXYGENASE (HUMAN) 26 5235 10339 0.9 2.OOE-07 AF262988.1 NT Homo sapilens TRIZ2-Interacting telomeric RAP1 protein (RAP1) mRNA, complete cds r-f) Page 67 of 196 Table 4

148 6344 10472 1.6 2.OOE-07 L77569.1 NT Homo sapiens DiGeorge syndrome cAtical region, telomeric end 148 5344 10473 1.6 2.0012-07 L77569.1 NT Homo sapiens DIGeorge syndrome critical region, telomedc end 5368 10494 40.0 2.OOE-07 U38849.1 NT Fugu rubripes beta- cytoplasmic(vascular) actin gene, complete cds 731 5885 11027 0.6 2.OOE-07 AF003530.1 NT Homo sapiens homcobox protein CDX4 (C1DX4) gene, complete cds and flanking repeat regions 731 5885 11028 0.6 2.OOE-07 AF003530.1 NT Horno sapiens homeobox protein CDX4 (CDX4) gene, complete cds and flanking repeat regions 928 6075 11233 1.1 2.OOE-07 AA223260.1 EST HUMAN zr08b07.s11 Stratagene NT2 neuronal precursor 937230 Homo sapiens cIDNA clone IMAGE:650869 3' similar to gb131860 GLYCOPHORIN A PRECURSOR (HUMAN); contains AW repetitive element; 929 6076 11234 1.2 2.OOE-07 T63042.1 ESTHUMAN yc15g04.sl Stratagene lung (#937210) Homo sapiens cIDNA done iMAGE:80790 Ysimilar to contains L1 repetitive element; 1147 6282 11435 1.3 2.0012-07 026768 SWISSPROT 116 AUTOANTIGEN 1582 6708 11879 0.7 2.OOE-07 Q09701 SWISSPROT HYPOTHETICAL 72.5 KID PROTEIN C2F7.10 IN CHROMOSOME 1 3633 8772 13866 14.7 2.OOE-07 AF125348.1 NT Homo sapiens caveolin 1 (CAV1) gene, exon 3 and partial ods 5078 10176 15255 1,0 2.OOE-07 AW070995.1 EST-HUMAN xa051107.xl Soares-NFL- T-G13C-S1 Homo sapiens cIDNA done IMAGE:2567485 Ysimilar to WP:C38H2.1 CE00923 PROBABLE RAI3GAP DOMAINS; 5078 10176 15256 1.0 2.OOE-07 AW070995.1 ESTHUMAN xa05h07.xl Scares - NFL - T - GBC - S1 Homo sapiens cIDNA done IMAGE:2567485 Ysimilar to WP:C38H2.11 CE00923 PROBABLE RABGAP DOMAINS; 5198 10289 15358 1.0 2.OOE-07 AL1 63301.2 NT Homo sapiens chromosome 21 segment HS21 Cl 01 1086 6224 1.2 1.OOE-07 A1-163282.2 NT Homo sapiens chromosome 21 segment HS21 C082 2331 7434 12642 0.9 1.OOE-07 P10263 SWISSPROT RETROVIRUS-RELATED GAG POLYPROTEIN (VERSION 1) 2403 7502 12709 0.9 1.OOE-07 7549818 NT Homo sapiens RAB, member of RAS oncogene family-like 2A (RABL2A), transcript variant 2, mRNA 2797 6632 11801 0.6 1.OOE-07 P09256 SWISSPROT GLYCOPROTEIN GPV 3684 6224 1.3 1.OOE-07 A1-163282.2 NT Homo sapiens chromosome 21 segment HS21 C082 591 7893 0.9 8.OOE-08 A1911352.1 EST-HUMAN wd16b05.xl Soares NFL T G13Q_S1 Homo saplenscIDNA done IMAGE:2328273 3' 73 5279 10406 1.1 7.OOE-08 Q02357 SWISSPROT ANKYRIN 1 (ERYTHROCYTE ANKYRIN) 1338 6466 11634 4.6 7.OOE-08 X04809.1 NT Rat mRNA for dbosomal protein L31 3528 8669 13772 1.1 7.OOE-08 P15305 SWISSPROT DYNEIN HEAVY CHAIN (DYHC) 3528 8669 13773 1.1 7.0012-08 P15305 SWISSPROT DYNEIN HEAVY CHAIN (DYHC) 800 5951 11101 1.0 6.OOE-08 AL163248.2 NT Homo sapiens chromosome 21 segment HS21C048 800 5951 11102 1.0 6.OOE-08 AL163248.2 NT Homo sapiens chromosome 21 segment HS21 C048 2312 7415 12624 0.6 6.OOE-08 BE144398.1 EST HUMAN MRO-HT0166-191199-004- 909 HT0166 Homo saplens cDNA 4155 9281 14361 1.0 6.OOE-08 AL163248.2 NT Homo sapiens chromosome 21 segment HS21C048 79 5285 10412 1,0 5.OOE-08 AL1 63303.2 NT Homo sapiens chromosome 21 segment HS21 Cl 03 2189 7298 12513 0.7 5.OOE-08 AA493851.1 EST HUMAN n1103b09.sl INICIWAP- Thyl Homo sapiens cIDNA done IMAGE:943193 similar to contains Alu repetitive element; 10270 15341 1.1 5.OOE-08 Q06278 SWISSPROT ALDEHYDE OXIDASE A 6847 12025 1.1 4.OOE-08 P25723 SWISSPROT DORSAL-VENTRAL PATTERNING TOLLOID PROTEIN PRECURSOR 6847 12026 1.1 4.OOE-08 P25723 SWISSPROT DORSAL-VENTRAL PATTERNING TOLLOID PROTEIN PRECURSOR Page 68 of 196 Table 4

5184 10276 15344 7.2 3.OOE-08 AA191195.1 EST-HUMAN zq45d05.rl Stratagene hNT neuron (#937233) Horno sapiens cDNA clone IMAGE:632649 5' 5184 10276 15345 7.2 3.0OE-08 AA1 91195.1 EST HUMAN zq45d05xl Stratagene hNT neuron (#937233) Homo saplens cDNA done IMAGE:632649 5' 199 5393 5.4 2.OOE-08 AW302996.1 EST-HUMAN xr87f06.xl NCI CGAP-Lu26 Homo saplens cDNA done IMAGE:2767139 3' 223 5416 2.7 2.0OE-08 AA425598.1 EST-HUMAN zw48f07xl Soares_total - fetus- Nb2HFQ_gw Homo sapiens cDNA clone IMAGE:773317 5, similar to contains Alu repetitive element;contalns element MER1 5 repetitive element:

488 5653 10777 0.5 2.OOE-08 AF198349.1 NT Gallus gallus Dach2 protein (Dach2) mRNA, complete cds 644 5803 10928 3.7 2.OOE-08 AW886438.1 EST-HUMAN MRO-OT0080-240200-001- 908 OT0080 Homo sapiens cDNA 644 5803 10929 3.7 2.0OE-08 AW886438.1 EST HUMAN MRO-OT0080.240200-001- g08 OT0080 Homo sapiens cDNA 974 6120 13,0 2.OOE-08 BE280477.1 EST-HUMAN 601155321 F1 NIH MGC 21 Homo saplens cDNA done IMAGE:3138893 5, 1319 W8 11614 0.7 2.OOE-08 AL163247.2 NT Homo saplens_chromosome 21 segment HS21C047 1363 6491 11656 0.9 2.00IE-08 4505538 NT Homo saplens oxylocin receptor (OXTR) mRNA 1811 6930 1.4 2.OOE-08 AW270271.1 EST-HUMAN xp43fl 1.xl NCI CGAP HNI 1 Homo sapJens cDNA done IMAGE:2743149 3' 2368 7470 12672 0.5 2.OOE-08 AW024364.1 EST-HUMAN wv03c08.xl NCI_CGAP_K1d3 Homo sapiens cDNA done IMAGE:2528462 Ysimilar to contains L1A2 1.1 repetitive element; 2496 7593 0.8 2.OOE-08 K002116.1 NT Sheep His-IRNA-GUG 3171.8320 13433 6.0 2.OOE-08 042280 SWISSPROT WNT-14 PROTEIN PRECURSOR 3171 8320 13434 6.0 2.OOE-08 042280 SWISSPROT WNT-14 PROTEIN PRECURSOR 3783 8920.1.7 2.OOE-08 AW813620.1 EST-HUMAN RC3-ST01 97-161099-012-b03 ST01 97 Homo saplens cDNA 3858 8994 14093 3.7 2.OOE-08 P48960 SWISSPROT LEUCOCYTE ANTIGEN CD97 PRECURSOR.

3986 9118 14201 0.8 2.OOE-08 U82668.1 NT Homo saplens shox gene, alternatively spliced products, complete cds 4305 9429 3,4 2.OOE-08 AA459040.1 EST HUMAN aa26c07xl NCI---WAP-GCB1 Homo sapiens cDNA done IMAGE:814380 5'stmilar to contains Ll.t2 L1 repetitive element; 4876 9983 2.9 2.OOE-08 AW572881.1 EST HUMAN he17h0B.x2 NCI-CGAP-PM1-11 Homo sapiens cDNA done IMAGE:2919327 Ysimilar to contains Alu repetitive element; 1493 7918 11789 1.1 1.OOE-08 P31792 SWISSPROT POL POLYPROTEIN lONTAINS: REVERSE TRANSCRIPTASE; ENDONUCLEASE) 2005 7119 1.1 1.OOE-08 BE141959.1 EST-HUMAN PM2-HT0130-150999-001412 HT0130 Homo saplens cDNA 2504 7601 12799 1.3 1.OOE-08 P33999 SWISSPROT HYPOTHETICAL 25.3 KI) PROTEIN IN RIMI-PRFC INTERGENIC REGION 3155 83 04 13413 1,2 1.OOE-08 BE246844.1 ESI_HUMAN TCBAPID5232 Pediatric: pre-B wit acute lymphoblasdc leukemia Baylor-HGSC project=TCBA Homo sapiens cDNA done TCBAP5232 3155 8304 13414 1.2 1.OOE-08 BE246844.1 EST HUMAN TCBAPID5232 Pedlatric pre-B cell acute lymphoblasdc leukemia Baylor-HGSC project--TCOA Horno sapiens cDNA clone TCBAP5232 5191 10282 15350 1.4 1.OOE-08 AL163280.2 NT Homo sapiens chromosome 21 segment HS21 C080 4149 9275 14355 3,0 9.ODE-09 AL163279.2 NT Homo sapiens chromosome 21 segment HS21 C079 4149 9275 14356 3.0 9.OOE-09 AL163279.2 NT Homo sapiens chromosome 21 segment. HS21 C079 3444 8586 1.1 8,0OE-09. BE012076.1 ES7-HUMAN RCS-BN1058-270400-031-CO6 BN1058 Homo saplens cDNA 3555 8694 1.7 7,OOE-09 D86842.1 NT Horno sapiens DNA for 3-ketoacyl-CoA thiolase beta-subunit of mitochondrial trifunctional prole n, exon 2, 3 4175 9301 14382 2.6 7.OOE-09 U89918.1 NT Macaw mulatta homeobox protein putative pseudogene c kf) Page 69 of 196 Table 4

4558 9676 14768 1.0 7.OOE-09 D00649.1 NT Homo sapiens gene for enteric smooth muscle gamma-actin, exon 2, 3 2107 7218 1.1 6.OOE-09 AL040439.1 EST-HUMAN DKFZp434C0514-rl 434 (synonym: htes3) Homo saplens cIDNA clone DKFZp434C0514 5, 3941 9074 14157 1.1 6.OOE-09 AA557940.1 EST-HUMAN n117al 1.sl NCLCGAP. _HSC1 Homo sapiens cDNA clone IMAGE:1040924 similar to contains 1.1.2 1.1 repetitive element; 4906 10013 15094 4.4 6.OOE-09 BE169421.1 EST HUMAN PM1-HT0527.160200-001- h05 HT0527 Homo sapiens cDNA 1394 6521 11689 1.1 5.OOE-09 BE149264.1 EST-HUMAN RC2-HT0252-120200-014h10 HT0252 Homo sapiens cDNA 510 5674 0.6 4.OOE-09 A1.163282.2 NT Homo sapiens chromosome 21 segment HS21 C082 949 6095 0.8 4.OOE-09 A1.163285.2 NT Homo sapiens chromosome 21 segment HS21 C085 2379 7481 12683 2.3 4.OOE-09 AA350878.1 EST-HUMAN EST58385 Infant brain Homo saplens cDNA V end similar to similar to beat shock protein, 90 kDa 2303 7406 12614 1,4 3.OGE-09 BE222239.1 EST-HUMAN hu09e09.xl NCL. CGAF_Lu24 Homo sapiens cDNA done IMAGE:3166120 Ysimilar to contains MER18.1:3 MER18 repetitive element; 2506 7602 12802 1.3 3.OOE-09 BE222239.1 EST HUMAN hu09e09.xl NCLWAP_Lu24 Homo sapiens cDNA done IMAGE:3166120 3' similar to contains MER113.Q MER18 repetitive element; 2614 7704 12903 1.1 3.OOE-09 P23249 SWISSPROT PROTEIN MOV-10 3287 8432 13540 1.1 3.OOE-09 BE222239.1 EST-HUMAN huO9eO9.xl NCLCGAP_Lu24 Homo sapiens cDNA done IMAGE:3166120 Ysimilar to contains MER18.t3 MER18 repetitive element; 4329 9452 14540 3.2 3.OOE-09 AF175325.1 NT Homo sapiens eukaryofic Initiation factor 4A1 EIF4A1) gene, partial ods 4411 9531 14620 1.5 3.OOE-09 Q9Y3R5 SWISSPROT 258.1 KDA PROTEIN C21 ORFS (K1AA0933) 795 5946 0,9 2.OOE-09 X16674.1 NT H.sapiens PADPRP-1 gene for NAD(+) ADP- ribosyitransferase 1237 6366 11527 1.8 2.OOE-09 AL163284.2 NT Homo saplens chromosome 21 segment HS21 C084 1637 6763 3.8 2.OOE-09 AL1 18573.1 EST HUMAN WZp761B1710-rl 761 (synonym: hamy2) Homo sapiens cDNA done DKFZp761B1710 5 2278 7384 12591 0.8 2.OOE-09 Q9Y3R5 SWiSSPROT 258.1 KDA PROTEIN C21 ORF5 (K1AA0933) 1093 6231 1382 0.9 1.OOE-09 5031 24 N omo saplens CCAAT-box-binding transcsiption factor (CBF2) mRNA 1093 6231 11383 0.9 1.0OE-09 5031624 NT Homo saplens CCAAT-box-binding transcription factor (C13F2) mRNA 1616 6742 1.0 1.00IE-09 AJ229041.1 NT Homo sapiens 959 kb condg between AM1.1 and CBRI on chromosome 21q22; segment 113 2453 7552 0.9 1.OOE-09 A1356086.1 EST-HUMAN qy64el 1.xl NCLCGAP_Brn25 Homo saplens cDNA done IMAGE:2016812 3'similar to contains MER12.Q MER12 repetitive element; 2860 8011 13112 1.5 1.0OE-09 U80017.1 NT Horno saplens basic transcription factor 2 p44 (btf2p44) gene, partial cds, neuronal apoptosis Inhibitory protein (nalp) and survival motor neuron protein (smn) genes, complete ods 2895 8046 13146 3.3 1.0OE-09 M28699.1 NT Homo sapiens nudeolar phosphoprotein B23 (NPIVI1) mRNA, complete cds 2895 8046 13147 3.3 1.0012-09 M28699.1 NT Homo saplens nudeolar phosphoprotein B23 (NPM1) mRNA, complete cds 2949 8100 13206 1.2 1.OOE-09 P11799 SWISSPROT MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE AND NON-MUSCLE ISOZYMES (MI.CK) [CONTAINS: TELOKIN] 4692 9804 4.3 1.0OE-09 AA719297.1 EST HUMAN zh35b03.sl Soares_plneal_gland - N3HPG Homo sapiens cDNA done IMAGE:414029 3' similar to contains Alu repetitive element;contalns element MER22 repetitive element 1287 6417 11580 0.6 9.OOE-10 AW867740.1 EST HUMAN MRO-SNO040-050500-002- c07 SNO040 Homo sapiens cDNA Page 70 of 196 Table 4

2803 7955 13064 6.0 9.0OE-110 A1870071.1 EST-HUMAN we78h03.xl Soares_Dieckgraefi_coiorLNHCD Horno sapiens cIDNA done IMAGE:2347253 3'sImilar to SW:R1-29 HUMAN P47914 60S RIBOSOMAL PROTEIN L29;wntains element PTR5 repetitive element,, 141 5337 10467 3.2 8.0OE-110 U63630.2 NT Horno saplens MCM4 (MCM4) and IDNA-PKw (PRKIDC) genes, partial ods 3300 8446 13554 0.9 8.0OE-110 BE080748.1 EST-HUMAN OV1-BT0631-150200-071- f01 BT0631 Homo sapiens cDNA 4106 9232 14314 2.8 8.0012-10 AA376832.11 EST HUMAN EST89564 Small Intestine 1 Honno saplens cIDNA Cend 686 5841 10976 4.2 7.0OE-110 7706225 NT Homo sapiens TPA Inducible protein (LOC51586), mRNA 686 5841 10977 4.2 7.0OE-110 7706225 NT Homo sapiens TPA Inducible protein (LOC51 86), mRNA 1605 6732 11903 0.7 7.OOE-10 Q13342 SWISSPROT LYSP1100 PROTEIN (LYMPHOID- RESTRICTED HOMOLOG OF SP1100) 1974 7089 1.0 7.0OE-110 P08548 SWISSPROT LINE-1 REVERSE TRANSCRIPTASE HOMOLOG 2512 7608 6.1 7.0OE-110 P08547 SWISSPROT LINE-1 REVERSE TRANSCRIPTASE HOMOLOG 3049 8200 13300 2.7 7.0OE-110 X00856.1 NT H.sapiens DHFIR gene, exon 3 895 6043 11198 1.0 6.0OE-110 AJ400877.1 NT Homo saplens ASCL3 gene, CEGP1 gene, C11orf14 gene, C1111orf15 gene, C11orf16 gene and Cl lorf17 gene 2644 7733 12934 0.5 6.OOE-10 A1424405.1 EST HUMAN t102d07.xl NCI CGAP Pr28 Homo saplens cIDNA clone IMAGE:2095021 3' 4634 9748 2.5 6.OOE-10 AW853719.1 EST HUMAN RC3-CTO254-031099-012-912 CT0254 Horno sapiens eDNA 744 5897 1.5 5.0OE-110 AL046804.1 EST-HUMAN DIKIFZp434N211 9Lrl 434 (synonym: htes3) Horno sapiens ciDNA clone DKIFZp434N21 9 5, 3430 8572 13684 1.5 5.OOE-10 Q01033 SWISSPROT HYPOTHETICAL GENE 48 PROTEIN 106 5309 3.0 4.OOE-10 A1221083.1 EST-HUMAN q909f09.xl Soares_placenta- 8togweeks-2NbHP8togW Horno sapiens cIDNA clone IMAGE:1759049 Ysimilar to contains LTR8.152 LTR8 repedfive element, 1951 7068 12264 1.4 4.0OE-110 AW594709.1 EST HUMAN hg58g03.xl ISICI-PGAP-- -GC6 Homo saplens cDNA clone IMAGE:2949844 3'sImilar to contains Alu repetitive element; 2527 7623 12824 2.2 4.0OE-110 A1.163303.2 NT Homo sapiens chromosome 21 segment HS21 Cl 03 3244 8391 13498 1,1 4.0OE-110 H01 109.1 EST-HUMAN yj26b12.sl Scares placenta Nb2HP Homo sapiens cONA done IMAGE: 149927 3'similar to contains THR repetitive element; 897 6044 11200 0.6 3.0OE-110 N36113.1 EST HUMAN yy32f06.sli Scares melanocyte 2Nbi-IM Horno sapiens cONA clone (MAGE:272963 Ysimilar to contains 1-11.0 L1 repetitive element; 4435 9556 146.49 1.1 3.0OE-110 AL1 63203.2 NT Homo saplens chromosome 21 segment HS21 C003 4435 9556 14650 1.1 3.0OE-110 AL163203.2 NT Homo saplens chromosome 21 segment HS21 C003 32 5241 10346 1.4 2.0OE-110 P48988 SWISSPROT MAJOR CENTROMERE AUTOANTIGEN B (CENTROMERE PROTEIN B) (CENP-13) 32 5241 10347 1.4 2.0OE-110 P48988 SWISSPROT MAJOR CENTROMERE AUTOANTIGEN B (CENTROMERE PROTEIN PI(CENP-B) 1855 6973 2.1 2.0OE-110 U80017.1 NT Horno sapiens basic transcription factor 2 p44 (btf2p44) gene, partial cds, neuronal apoptosis Inhibitory protein (naip) and survival motor neuron protein (smn) genes, complete cds 1492 6619 1.3 1.OOE-10 AW867767.1 EST HUMAN MRO-SNO038-290300-001-f01 SNO038 Homo saplens cDNA 2537 7633 0.9 1.0OE-110 AW852001.1 EST HUMAN QVO-CT0225-19111199-058-e08 CTO225 Homo sapiens cDNA 3456 8597 13710 0.9 1.OOE-10 AW832912.1 EST-HUMAN QV2-TT0003-161199-013- 910 TT0003 Horno sapiens cIDNA 3770 8636 0.9 1.0OE-110 AL041685.1 EST HUMAN DKFZp434N1317rl 434(synonym: htes3)HomosapienscDNAcJoneDKFZp434N13175' Page 71 of 196 Table 4

3933 9067 5,4 1.OOE-10 AF213884.1 NT Homo sapiens nuclear factor of kappa light polypepfide gene enhancer in B-cells 1 (NFKB 1) gene, complete cds 4036 9164 14248 4.5 1.0OE-10 L152111.2 NT Homo saplens X28 region near ALD locus containing dual spedficity phosphatase 9 (DUSP9), ribosomal protein L1 8a (RPL1 8a), Ca2+1Calmodulin-dependent protein kinase 1 (CAMKI), creatine transporter (CRTR), CDM protein (CDM), adrenoleukodystrophy protein > 4036 9164 14249 4.5 1.OOE-10 U52111.2 NT Homo sapiens X28 region near ALD locus containing dual specificity phosphatase 9 (DUSP9), ribosomal protein L1 8a (RPL1 8a), Ca2+/Calmodutindependent protein kinase 1 (CAMK. 1), creadne transporter (CRTR), CDM protein (CDM), adrenoleukodystrophy protein > 4042 9170 14256 2.3 1.OOE-10 AB031069.1 NT Homo saplens PC= mRNA for protein containing CX= domain 1, complete ods 4079 9206 2.1 1.OOE-10 M30629.1 NT Human pregnancy-specific glycoprotein beta-1 (SP1) mRNA, last exon 5145 10240 0.9 1.OOE-10 X87344.1 NT H.sapiens DMA, DIVIB, HLA-ZI, IPP2, LMP2, TAP1, LIVIP7, TAP2, DOB, DQB2 and RING8, 9, 13 and 14 genes 261 5448 10574 1.2 9.00EA 1 BE145600.1 EST HUMAN IU-HT0203-291099-016-c08 HT0203 Homo sapiens cDNA 2057 7169 12375 2.0 9.00EA 1 AL134395.1 EST-HUMAN DKFZp547D22_rl 547 (synonym: hfbrl) Homo saplens cDNA clone DKFZp54713225 5, 2057 7169 12376 2.0 9.00EA 1 AL134395.1 EST-HUMAN DIKFZp547D225-rl 547 (synonym: hfbrl) Horno sapiens cIDNA clone DIKI7Zp547D225 5' 3337 8481 13596 2.3 9.00EA 1 AL1 34395.1 EST HUMAN DOZp547D225-rll 547 (synonym: hfbrl) Horno sapiens cDNA clone WZp54713225 5.

3337 8481 13597 2.3 9.00EA 1 AL134395.1 EST-HUMAN DKFZp547D225-rl 547 (synonym: hfbrl) Horno sapiens cDNA clone URp547D225 C 4400 9521 14611 1.1 9.00EA 1 AA775985.1 EST-HUMAN ae78f0I.sli Stratagene schizo brain SI l Horno sapiens cDNA clone IMAGE:970297 X 3078 8229 10.0 8.00EA 1 H19971.1 EST-HUMAN yn53f11.sl Soares adult brain N2b5HG5SY Homo sapiens cDNA clone IMAGE:172173 X similar to contains 1.1 repetitive element; 3881 9017 14112 0.8 8.00EA 1 A1478617.1 EST HUMAN tm54c09.xl NCI_C Kidl 1 Horno sapiens cDNA clone IMAGE:2161936 3, 3957 9090 14173 4.0 8.00EA 1 N23712.1 EST-HUMAN yw46e06.sl Weizmann Olfactory Epithelium Homo sapiens cDNA clone IMAGE:255298 3, 1431 6558 11734 0.8 7.00EA 1 AA330642.1 EST-HUMAN EST34392 Embryo, 6 week 1 Homo saplens cDNA Vend 406 5574 10712 1.8 6.00EA 1 M55270.11 NT Human matrix Gla protein (MGP) gene, complete cds 406 5574 10713 1.8 6.00EA 1 M55270.1 NT Human matrix Gla protein (MGP) gene, complete cds 11 5219 10320 0.9 5.00EA 1 AL163283.2 NT Homo sapiens chromosome 21 segment HS21C083 3320 5219 10320 1.5 5.00EA 1 AL163283.2 NT Homo sapiens chromosome 21 segment HS21 C083 4135 9261 14343 1.5 5.00EA 1 P48034 SWISSPROT ALDEHYDE OXIDASE 1380 6507 1.4 4.00EA 1 AA436042.1 EST HUMAN zu01b12xl Soares tesfi!s_NHT Horno sapiens cDNA done IMAGE:730559 5' 4518 9637 14728 1.4 4.00EA 1 D44666.1 EST-HUMAN HUMSUPY069 Human brain cDNA Homo sapiens cDNA done 069 1476 6603 11777 0.8 3.00EA 1 6679077 NT Mus musculus expressed In non- metastadc cells 2, protein NM23B) (Nme2), mRNA 4179 9305 1.5 3.00EA 1 AA309248.1 EST HUMAN EST1 80120 Liver, hepatocellular carcinoma Homo sapiens cDNA 5' end 944 6091 11248 0.5 2.00EA 1 AI 150502.1 EST_HUMAN qf36604.xl SoareeJestis - NHT Horno sapiens cDNA done IMAGE:1752102 3' similar to contains MER1O.t3 MERO repetitive element; Page 72 of 196 Table 4

1168 6302 11458 1.2 2.0OE-111 R24807.1 EST HUMAN y943el 2.rl Scares Infant brain 1 NIB Honio sapiens cDNA done IMAGE:35144 5' 1168 6302 11459 1.2 2.00EA 1 R24807.11 ESTHUMAN yg43e12.rl Soares Infant brain 1 NIB Homo saplens cDNA done IMAGE:35144 5' 1596 6722 11891 1.4 2.0OE-111 L17432.1 NT Gallus gaflus rho-globJn, beta- H globIn, beta-A globin, epsilon-globin, and olfactory receptor like protein CORYbeta (CORYbeta) genes, complete cds 1596 6722 11892 1.4 2.00EA 1 L17432.1 NT Gallus gailus rho-globin, beta-H globin, beta-A globin, epsilon-globin, and olfactory receptor like protein CORYbeta (COR3'beta) genes, complete cds 1600 6727 11897 1.0 2.00EA 1 A1126371.1 EST HUMAN qc51c10.xl SoareMregnant-uterus-NbHPU Horno sapiens cDNA done IMAGE:1713138 3' similar to 9b102932 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA (HUMAN);contains 1.1.0 L1 repetitive element; 2737 7821 13025 1.1 2.00EA 1 AF087913.1 NT Human endogenous retrovIrus HERV-P-T47D 3160 8309 13421 4.2 2.00EA 1 P10263 SWISSPROT RETROVIRUS-RELATED GAG POLYPROTEIN (VERSION 1) 3284 8429 13537 0.9 2.00EA 1 A1478617.1 EST HUMAN 1m54c09.xl NCI_CGAP_Kidl 1 Homo sapiens cDNA done IMAGE:2161936 3, 3452 8593 1.0 2.00EA 1 AF020503.1 NT Homo sapiens FRA3B common fragile region, diadenosine triphosphate hydrofase (FHIT) gene,exon 5 4501 9621 1.0 2.00EA 1 AL1163227.2 NT Homo saplens chromosome 21 segment HS21C027 4851 9958 5.5 2.00EA 1 BE062558.1 EST-HUMAN QV2-BT0258-261099-014-a01 ST0258 Homo saplens cDNA 4961 10064 15136 1.3 2.00EA 1 AA307331.1 EST - HUMAN EST178226 Colon carcinoma (HCC) cell line Homo sapiens cDNA Vend similar to similar to alpha-2-macroglobulin 660 5816 10944 1.2 1.OOE-1 1 AJ131016.1 NT Homo sapiens SCL gene locus 1199 6331 11486 0.9 1.0OE-11 1 AL163279.2 NT Homo saplens chromosome 21 segment HS21C079 1249 6378 11537 1.6 1.OOE-1 1 AA489871.1 EST-HUMAN ab011b12A Stratagene fetal retina 937202 Homo saplens cDNA done IMAGE:839519 V similar to contains OFR.t2 MER10 repetitive element; 1483 6610 0.7 1.00EA 1 An19914.11 NT Homo sapiens PR03078 mRNA, complete ods 1838 6957 1.2 1.00EA 1 A13030947.11 NT Rattus norvegicus mRNA for high- affinity choline transporter CHT1. complete ods 2079 7191 12394 1.1 i.oor=-1 1 AF000573.1 NT Homo sapiens homogendsate 1, 2-dlpnfflenase gene, complete cds 3454 8595 13706 1.3 1.0OE-11 1 BE004315.1 ESTHUMAN CMO-BN0105-170300-292- d12 BN0105 Horno sapiens cDNA 3798 8935 14028 27.7 1.0OE-1 1 ABOO1523.1 NT Homo saplens gene for TMEM1 and MP2,complete and partial ods 3798 8935 14029 27.7 1.00EA 1 A13001523.1 NT Homo sapiens gene for TMEM1 and PWP2,comelete and partial ods 2922 6073 13181 0.8 9.OOE-12 P20742 SWISSPROT PREGNANCY ZONE PROTEIN PRECURSOR 4562 9680 14773 2.8 7.OOE-12 005904 SWISSPROT 34 K1) SPICULE MATRIX PROTEIN PRECURSOR (LSM34) 4252 9377 14457 7.9 6.OOE-12 AA732516.1 EST - HUMAN nz88fl 1.sl NCLCGAP_GCBI Homo saplens cDNA done WAGE:1 302573 3'similar to contains Alu repetitive element; 1027 6167 11322 1,0 5.OOE-12 TO6573.1 EST HUMAN EST04462 Fetal brain, Stratagene (cat#936206) Homo sapiens cDNA done HFBDV33 3344 8488 13602 1.2 5.OOE-12 BEW779.1 EST - HUMAN tz42b05.yl NCI CGAP 13m52 Homo sapiens cDNA done IMAGE:2291217 S' 3666 8805 13899 5.9 5.0OE-12 A.1271736.1 NT Homo sapiens Xq pseudoautosomal region; segment 212 5171 10265 0.8 5.OOE-12 AA720661.1 EST-HUMAN nw24bil,sI NCI CGAP_GWO Homo saplens cDNA done IMAGE: 1241373 3' 244 5433 10559 1.2 4.OOE-12 AA700326.11 EST-HUMAN z174g11.sl Soares_fetaUlveLspleer)_INFLS_S1 Homo sapiens cDNA done IMAGE:460676 3 245 5433 10559 1.2 4.OOE-12 AA700326.1 EST-HUMAN zj74g11.sl Soares_fetaLliver_spieen-1NFLS-S1 Homo sapiens cDNA clone IMAGE:460676 3' 3126 8275 13380 2.2 4.OOE-12 Q04791 SWISSPROT FATTY ACYL.COA HYDROLASE PRECURSOR, MEDIUM CHAIN (THIOESTERASE B) Page 73 of 196 Table 4

3126 8275 13381 2.2 4.OOE-12 004791 SWISSPROT FATTY ACYL-COA HYDROLASE PRECURSOR, MEDIUM CHAIN (THIOESTERASE B)__ tK26h05.xl NCI_PGAP_Lu24 Homo sapiens cDNA clone IMAGE:2270745 Ysimilar to 4520 9639 14730 0.9 4.OOE-12 A1689984.1 EST_HUMAN TR:W 3539 013539 MARINER TRANSPOSASE.

420 5209 10310 1.3 3.OOE-12 042163 SWISSPROT COCHLIN PRECURSOR (COCH5132) W13d01xl Soare_NFGBC S1 Homo sapiens cDNA done IMAGE:2909377 Ysimilar 600 5758 10877 1.3 3.OOE-12 AW341683.1 EST HUMAN to TR:014517 014517 SIVIRP W13d01.xl Soares_NFL-T-Gl3Q_S1 Homo sapiens ONA done IMAGE:2909377 3'similar 600 5758 10878 1.3 3.OOE-12 AW341683.1 EST HUMAN to TR:014517 014517 SMRP. ; 2864 8015 13117 1.4 2.OOE-12 AW341809.1 EST HUMAN haO2d05.xl NCI CGAP Lu24 Homo saplens cIDNA clone IMAGE:2872521 3' 2864 8015 13118 1.4 2.OOE-12 AW341809.1 EST-HUMAN haO2d05.xl NCI CGAP Lu24 Homo saplens ciDNA done IMAGE:2872521 3' 3421 8563 13675 1.0 2.OOE-12 6754495 NT Mus musculus kerafin-assodated protein 6.2 (K p6-2), mRNA 4025 9153 14236 1.0 2.OOE-12 J01884.11 NT Rat U3A small nuclear RNA 4025 9153 14237 1.0 2.OOE-12 J01884.1 NT Rat U3A small nuclear RNA 4288 8015 13117 3.3 2.0012-12 AW341809.1 EST HUMAN ha02d05.xl NCI CGAP Lu24 Homo sapiens cDNA done IMAGE:2872521 3, 4288 8015 13118 3.3 2.OOE-12 AW341809.1 EST HUMAN ha02d05.xl NCI CGAP Lu24 Homo sapiens cIDNA done IMAGE:2872521 3' 4324 9447 1.8 2.OOE-12 BE063509.1 EST_HUMAN CMO-BT0281-031199-087-a03 BT0281 Homo sapiens cDNA 4804 9914 15005 0.8 2.OOE-12 070306 SWISSPROT T13Xl 5 PROTEIN (T-BOX PROTEIN 15) 4804 9914 15006 0.8 2.OOE-12 070306 SWISSPROT TBX15 PROTEIN (T-BOX PROTEIN 15) hh90a09.xl NCLWAP-GU1 Homo saplens cDNA done IMAGE:2970040 3'slmilar to 117 5317 10446 0.6 1.0012-12 AW627674.1 EST HUMAN contains MER18A1 MER18 repetitive element; wrn51f07.xl NCI CGAP W2 Horno sapiens cDNA done IMAGE:2439493 Ysimilar to 1944 7061 0.7 1.OOE-12 A1871726.1 EST HUMAN contains 1.113 Cl repeflive element; 3032 8184 13284 1.2 1.OOE-12 AF000991.1 NT Homo sapiens tests-spedfl Testis Transcript Y 2 (TTY2) mRNA, partial ods 3032 8184 13285 1.2 1.0OE-12 AF000991.1 NT Homo saplens tesds-spedfic Testis Transcript Y 2 (TTY2) mRNA, partial cds 3575 8714 1.1 9.OOE-13 AJ271735.1 NT Homo saplens Xq,pseudoautosomal region; segment 112 3865 9001 14102 1.2 9.OOE-13 A13029900.1 NT Homo sapiens CST gene for cerebroside suifotransferase, exon 1, 2, 3, 4, 5 700 5855 10990 1,7 8.0012-13 U29185.11 NT Horno sapiens prion protein (PrP) gene, complete cds 700 5855 10991 1.7 8.OOE-13 U29185.1 NT Horno sapien prion protein (PrP) gene, complete cds Homo sapiens basic transcription factor 2 p44 (b112p44) gene, parfial cds, neuronal apoptosis inhibitory protein (naip) and survival motor neuron protein (smn) genes, complete cds 1796 6916 12102 1.4 8.OOE-13 U80017.1 NT 2054 7166 12372 6.7 6.OOE-13 AL163207.2 NT Homo, saplens chromosome 21 segment HS21C007 1815 6934 12123 1.8 5.OOE-13 Q04899 SWISSPROT SERINE/THREONINE-PROTEIN KINASE PCTAIRE-3 1815 6934 12124 1.8 5.OOE-13 Q04899 SWISSPROT SERINE/THREONINE-PROTEIN KINASE PCTAIRE-3 3280 8425 1.1 5.OOE-13 R78338.1 EST-HUMAN Y182f04.rl Soares placenta Nb2HP Homo saplens cDNA done IMAGE:145759 5' zt77a12.sl Soares-tesds_NHT Homo sapiens ciDNA done IMAGE:728350 3'similar to 3351 8495 1.5 5.0012-13 AA435773.1 ESTHUMAN contains Alu repetitive element;contalns element MER22 repetitive element; 1824 6943 1.1 4.OOE-13 AW378614.1 EST HUMAN PM2-HT0224-221099-001 -ell HT0224 Horno, sapiens c1DNA 2411 7510 0.6 4.OOE-13 AF003529.1 NT '5s and flanking repeat regions Homo sapiens glypican 3 (G12C3) gene, partial c Homo sapiens X-linked anhidrolfic ectodermal dysplasia protein gene (EDA), exon 2 and 173 5366 1.3 3.OOE-13 AF003528.1 NT flanking repeat regions Page 74 of 196 Table 4

847 5996 1.4 3.OOE-13 AA430310.1 ESTHUMAN zw68g08.rl Soare!ests NHT Homo saplens cDNA done IMAGE:781406 5' 2319 7422 12631 1.3 3.OOE-13 AJ271736.1 NT Homo sapiens Xq pseudoautosomal region; segment 2J2 2429 7528 1.0 3.OOE-13 AL1 63210.2 NT Homo saplens chromosome 21 segment HS21 C01 0 3150 8299 2.9 3.OOE-13 AA745844.1 EST-HUMAN ob18d02.91 NCI_WAP KM5 Horno sapiens cDNA clone IMAGE:1324035 3' 144 5340 104701 1.0 2.OOE-13 U52111.2 NT Horno sapiens X28 region near ALD locus containing dual spedficity phosphatase 9 (DUSP9), ribosomal protein L18a (RPLI8a), Ca2+1Calmodulin-dependent protein kinase 1 (CAMKI), creadne transporter (CRTR), WM protein (CDM), adrenoleukodystrophy protein > 239 5429 10556 1.3 2.OOE-13 U23839.1 NT Danio redo fibroblast growth factor receptor 4 mRNA, complete cds 4019 9148 1,7 2.OOE-13 AL-163278.2 NT Homo Zapiens chromosome 21 segment HS21C078 4488 9608 14701 1,5 2.OOE-13 AF135116.1 NT Homo sapiens NIX-E2-related factor 3 gene, complete cds 288 5474 10604 1.4 1.0OE-1 3 S74129.1 NT FGF-1 --fibroblast growth factor 1 [uman, kidney, Genomic, 342 nt, segment 2 of 21 870 U518 11178 1.5 1.0OE-13 AJ007973.1 NT Homo sapiens LGIVID2B gene 1228 6358 1.2 1.OOE-13 A1.163213.2 NT Horno saplens chromosome 21 segment HS21 C01 3 1314 6442 11609 1.3 1.OOE-13 X87344.1 NT H.sapiens DMA, DMB, HLA-Zl, IPP2, LM132, TAP1, LMP7, TAP2, DOB, D082 and RING8, 9. 13 and 14 genes 1976 7091.12293 0.8 1.0OE-13 AA720574.1 EST-HUMAN nw21902.sl NCI CGAP GCBO Homo saplens cIDNA done IMAGE:1241138 3'sImilar to contains'THR.t3'HR reeuuve element; 330 5511 10637 1.0 9.OOE-14 AA781159.1 EST-HUMAN aj24c01.sl Soares_tesUs- NHT Homo saplens cIDNA done 1391232 3' similar to contains MER119.1:1 MER19 repetitive element; 331 5512 10638 1,0 9.0011-14 AA781159.1 EST-HUMAN aj24c0I.sl Soares- testis_NI-IT Horno saplens cIDNA done 1391232 Ysimilar to contains MER19.0 MER19repetifive element., 2451 7550 1.5 9.OOE-14 AW861577.1 ESTHUMAN_ RC4-CT0322-08010(1.013-d09 CT0322 Homo sapiens cIDNA 2725 7809 13014 1.7 9.OOE-14 AW513296.1 EST-HUMAN xo54h05.xl NC(_PGAP_qtl Homo saplens cIDNA done IMAGE:2707833 3, 3073 8224 13322 3.7 9.OOE-14 AW513296.1 EST-HUMAN xo5C05.xl NCI CGAP_Utl Homo sapJens cIDNA clone IMAGE:2707833 31 3200 5511 10637 1.0 9.OOE-14 AA781 159.1 ES7_HUMAN a124c0I.sl Soares- tesfis_NHT Homo saplens c1DNA done 1391232 X similar to contains MER1 9.tl MER1 9 repetitive element; 3728 8865 13958 5.2 9.OOE-14 D14547.1 NT Human DNA, SINE repetitive element 4650 9762 14857 1.9 9.OOE-14 AJ002153.1 NT Saguinus oedipus gene for seminal veside secreted protein semenogelin 1 3453 8594 1.6 8.OOE-14 BE46B263.1 ESTHUMAN hz71c09.xl ISICI---PGAP W24 Homo sapiens c(DNA clone IMAGE:3213424 3' 3872 9008 2.8 8.OOE-14 R76269.1 EST HUMAN yi72e03.rl Soares placenta Nb2HP Homo sapiens cIDNA done IMAGE. 144796 3' 1611 7921 1.1 7.OOE-14 AW151673.1 EST-HUMAN xf67e10.xl NCI_CGAP_Gas4 Horno sapiens cIDNA done IMAGE:2623146 Ysimilar to contains MER1 0.1:2 MER1 0 repetitive element; 363 5541 10672 3.5 6.OOE-14 AF020503.1 NT Homo saplens FRA38 common fragile region, diadenosine triphosphate hydrolase (FHIT) gene, exon 5 4861 9968 15053 1.0 6.OOE-14 T90961.1 EST HUMAN yd58a12.sl Soares fetal liver spleen WLS Horno, saplens cIDNA clone IMAGE:1 12414 3' 5114 10210 15288 1.0 6.OOE-14 8923548 NT Horno saplens hyRothedcal protein FLJ20585 (IFU20585), mRNA 5114 10210 15289 1.0 6.OOE-14 8923548 NT Homo sapiens hypothetical protein FLJ20585 (FU20585), mIRNA U\ 1 Page 75 of 196 Table 4

602 5760 10880 1.3 5.OOE-14 Q63120 SWISSPROT CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER 1 (MULTIDRUG 4985 10088 15160 1.1 5.OOE-14 AW073791.1 ' RESISTANCE-ASSOCIATED PROTEIN 2) (CANALICULAR MULTIDRUG RESISTANCE EST HUMAN PROTEIN) xb03b05.xl NCLWAP-GU1 Homo sapiens cDNA clone IMAGE:2575185 Ysimilar to contains Ll.t2 L1 repetitive element; 1107 7907 0.6 4.0012-14 P04928 SWISSPROT S-ANTIGEN PROTEIN PRECURSOR 1835 6954 12140 2.4 4.OOE-14 AJ007973.1 NT Horno sapiens LGIVID213 gene 3693 8832 0.9 4.00IE-14 AA046502.1 EST HUMAN zk67a06xl Soares_pregnant- uterus_NbHPU Homo saplens cDNA clone IMAGE:487858 5' 4194 9320 14405 1.0 4.OOE-14 N46328.1 EST HUMAN yy73c12.s11 Soares_multiple - sderosi5_2NbHMSP Homo sapiens cDNA clone IMAGE:279190 Ysimilar to contains Ll.t3 L1 repetitive element; 934 6081 11237 0.7 3.OOE-14 XW66.1 NT R.norvegicus mRNA for CPG2 protein 4841 9948 15037 0.8 3.0OE-114 AW265354.1 EST HUMAN xp45f12.xl NCI - C_HW 1 Horno sapiens cDNA done IMAGE:2743343 3'similar to contains Mu repetitive element;contains element MER9 repetitive element.

4844 9951 15039 1.1 3.OOE-14 7656864 NT Homo sapiens a disintegrin and metalloproteinase domain 29 (ADAM29), mRNA 5104 10200 1.2 3.OOE-14 BE466372.1 EST_HUMAN hx901 1.xl NCI-CGAP_Kidl 1 Homo sapiens cDNA clone IMAGE:3195501 3'similar to contains MER412 MER4 repetitive element; 5157 10262 15323 1.5 3.OOE-14 P02894 SWISSPROT CIRCUMSPOROZOITE PROTEIN PRECURSOR (CS) 384 5553 10686 1.4 2.OOE-14 AJ271736.1 NT Homo saplens Xq pseudoautosornal regiorr, segment 212 384 5553 10687 1.4 2.OOE-14 A.1271736.1 NT Horno sapiens Xq pseudoautosornal region; segment 212 675 7895 10960 2.2 2.OOE-14 A1-163303.2 NT Homo saplens chromosome 21 segment HS21 Cl 03 2339 7441 1.4 2.OOE-14 AW372868.1 EST-HUMAN RC5-13T0377-091299-031-1)12 BT0377 Horno sapiens cDNA 2416 7515 1.1 2.00E.14 7657529 NT Homo sapiens rhabdold tumor deletion region protein 1 (RTDR1), mRNA 2479 7577 12778 1.2 2.OOE-14 AL163209.2 NT Homo sapiens chromosome 21 segment HS21 C009 2640 7729 1,0 2.OOE-14 P08548 SWISSPROT LINE-1 REVERSE TRANSCRIPTASE HOMOLOG 1051 6190 11342 1.3 1.OOE-14 A1-163246.2 NT Homo sapiens chromosome 21 segment HS21C046 1384 6511 11675 2.8 1.OOE-14 A1.163268.2 NT Homo sapiens chromosome 21 segment HS21C068 1384 6511 11676 2.8 1.OOE-14 AL-163268.2 NT Homo sapiens chromosome 21 segment HS21 C068 1956 7073 12270 7.8 1.OOE-14 L44140.1 NT Homo sapiens chromosome X region from filamin (FLN) gene to glucose-6-phosphate dehydrogenase (G6PD) gene. complete ods's 2137 7247 12453 2.2 1.OOE-14AL163303.2 NT Homo saplens chromosome 21 segment HS21 Cl 03 2358 7460 12666 2.3 1.OOE-14 AF001689.1 NT Homo saple s dbosomal protein L23A (RPI-23A) gene, complete cds 2914 8065 13173 1,4 1.OOE-14 P05227 SWISSPROT HISTIDINE-RICH PROTEIN PRECURSOR (CLONE P1F1r1RP-11) 3811 8948 14044 2.0 1.OOE-14 AA682994.1 EST HUMAN ae89c12.sl Stratagene schizo brain S1 1 Homo saplens cDNA clone IMAGE:971350 3' 4374 9496 14583 1,7 1.OOE-14 AW275852.1 EST HUMAN xq39h10.xl NCI CGAP Lu28 Homo saplens cDNA done IMAGE:2753059 3' 1558 6685 11852 1.0 9.00EA 5 7427522 NT Homo saplens protein tyrosine phosphatase, receptor type. T (PTPRT), mRNA 1703 6826 12007 1.2 9.OOE-15 A1-163283.2 NT Homo sapiens chromosome 21 segment HS21 C083 1703 6826 12008 1.2 9.OOE-15 A1-163283.2 NT Horno sapjens chromosome 21 segment HS21C083 Page 76 of 196 Table 4

2126 7236 0.6 9.OOE-15 AF196779.1 NT Homo sapiens transcription factor IGHM enhancer 3, JMI 1 protein, JM4 protein, JM5 protein, T54 protein, JMIO protein, A4 differendation-dependent protein, triple LIM domain protein 6, and synaptophysin genes, complete cds; and L-typb calclum channel a> 2780 5637 1.0 8.OOE-15 BE261482.1 EST - HUMAN 601148632F1 NIM MGCJ 9 Homo saplens cONA clone IMAGE:3164023 5' 978 6123 11280 2.1 6.OOE-15 AJ271736.1 NT Homo sapiens Xq pseudoautosomal region; segment 212 404 5572 10709 2,0 5.00EA 5 AL163208.2 NT Homo saplens chromosome 21 segment HS21 C008 2733 7817 13022 1.4 5.OOE-15 U91328.1 NT Human hereditary haemochromatosis region, histone 2A-like protein gene, hereditary haemochromatosis (HLA-H) gene, RoRet gene, and sodium phosphate transporter (NPT3) gene, complete cds 3423 8565 1.0 5.OOE-15 AW296817.1 EST-HUMAN Ul-H-BWO-ajb-9-10-0-Ut.sl NCI- CGAP_Sub6 Homo saplens cIDNA done IMAGE:2731219 X 421 5210 10311 0.9 4.OOE-15 AL163303.2 NT Homo saplens chromosome 21 segment HS21 Cl 03 2612 7702 3.0 4.0OE-15 H5561 1,1 EST HUMAN CHR220550 Chromosome 22 exon Horno sapiens cDNA clone C22 749 6 4039 9167 14252 0.8 4.OOE-15 ALI 18596,1 EST-HUMAN DKFZp761 C081 0-rl 761 (synonym: hamy2) Horno sapiens cDNA clone DKFZp761 C081 0 51 4123 9249 5.9 3.OOE-15 N89452.1 EST HUMAN LY1 142F Human fetal heart, Lambda ZAP Express Homo saplens cDNA clone LY1 142 5, similar to ANF(CARDIODILATIN) 4843 9950 1.4 3.OOE-15 P92485 SWISSPROT NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5 4965 10060 15131 0.9 3.OOE-15 AA078097.1 EST-HUM 7P01F03 Chromosome 7 Placental cIDNA Library Homo sapiens cIDNA clone 7P01F03 4955 10060 15132 0.9 3.OOE-15 AA078097.1 EST-HUMAN 7P01 F03 Chromosome 7 Placental cDNA Library Homo sapiens cIDNA Clone 7P01 F03 250 5438 10565 1.1 2.OOE-15 AF223391.1 NT Homo sapiens calcium channel alphal E subunit (CACNA1 E) gene, exons 7-49, and partial cds, alternatively spliced 364 5542 10673 1.1 2.OOE-15 AF223391.1 NT Homo saplens calcium channel alphal E subunit (CACNA1 E) gene, exons 7-49, and partial ods, alternatively spliced 364 5542 10674 1.1 2.OOE-15 AF223391.1 NT Homo sapiens calcium channel alphal E subunit (CACNA1 E) gene, exons 7-49, and partial cds, alternatively spliced 1512 6639 1.1 2.OOE-15 8923201 NT Homo saplens hypothetical protein FLJ20212 (FLJ20212), mRNA 3465 8606 13718 1.0 2.OOE-15 AF223391.1 NT Homo saplens calcium channel alphal E subunit (CACNA1 E) gene, exons 7-49, and partial cds, alternatively spliced 3465 8606 13719 1,0 2.OOE-15 AF223391.1 NT Horno saplens calcium channel aiphal E subunit (CACNA1 E) gene. exons 7-49, and partial cds, alternatively spliced 4522 9641 2.1 2.OOE-15 A1806335.1 EST HUMAN wf07fO6.xl Soares_NFGBC_SI Homo saplens cDNA clone IMAGE:2349923 3'sImilar to TR:Q61043 Q61043 NINEIN.; 5097 10194 15273 1.3 2.OOE-15 P13993 SWISSPROT REPETITIVE PROLINE-RICH CELL WALL PROTEIN 2 PRECURSOR 5097 10194 15274 1.3 2.OOE-15 P13993 SWISSPROT REPETITIVE PROLINE-RICH CELL WALL PROTEIN 2 PRECURSOR 2747 7831 0.7 1.OOE-15 A1689984.1 EST_HUMAN tx26h05.xl NCI_PGAPjW24 Homo sapiens cDNA done IMAGE:2270745 3'slmilar to TR:W 3539 013539 MARINER TRANSPOSASE.; 2979 8130 13238 0.8 1.00EA 5 BE043584.1 EST HUMAN h"2g02,yl NCI WAI2J0v34 Homo sa lens cDNA clone IMAGE:2999162 5, 3103 8253 13357 1.0 1.OOE-15 P08547 SWISSPR LINE-1 REVERSE TRANSCRIPTASE HOMOLOG 4262 9387 14471 0.8 1.OOE-15 BE182696.1 EST HUMAN RC3-HT0649-100500-022- b05 HT0649 Homo sapiens cIDNA Page 77 of 196 Table 4

5086 10184 15263 1.2 1.OOE-15 A1984928.1 EST HUMAN wr86e04.xl NCI_PGAP_Kidl 1 Homo sapiens cDNA done IMAGE:2494590 3' 4404 9524 14614 1.0 9.OOE-16 4503168 NT Homo sapiens cut (Drosophila)- like 1 (CCAAT displacement protein) (CUTI-1) mRNA 2094 7205 3.0 6.OOE-16 AW97261 1.1 EST HUMAN EST384702 MAGE resequences, MAGI- Homo, sapiens cDNA 1477 6604 11778 1.1 5.OOE-16 AJ251154.1 NT Mus musculus olfactory receptor duster, OR37A, OR37B, OR37C, OR37E genes and OR37D pseudogene 2647 7736 12936 0.7 5.OOE-16 AA992176.1 EST HUMAN ot80c04.sli Soares - totaLfetus_Nb2HFQ_gw Homo sapiens cDNA clone IMAGE:1623078 3, similar to contains element L1 repetitive element; 2192 7301 1.3 4.OOE-16 A13001523.1 NT Homo sapiens gene for TMEM1 and PWP2,complete and partial cds 2328 7431 12639 1.3 4.OOE-li- AW797168.1 EST HUMAN QV1 -UM0036>200300.1 1 "02 UM0036 Horno saelens cDNA 2328 7431 12640 1.3 4.OOE-16 AW797168.1 EST HUMAN QV1-UM0036-200300-115- g02 UM0036 Homo sapiens cDNA 3411 8553 13661 3.9 4.OOE-16 Q16653 SWISSPROT MYELiWOLIGODENDROCYTE GLYCOPROTEIN PRECURSOR 4050 9177 14260 3.6 4.OOE-16 BE083875.1 EST HUMAN PM4-BT0650-010400-002909 BT0650 Homo sapiens cDNA 4050 9177 14261 3.6 4.OOE-16 BE083875.1 EST-HUMAN PM4-BT0650-010400-002- 909 BT0650 Homo sapiens cDNA 6092 10190 15269 1.0 4.OOE-16 P08548 SWISSPROT LINE-1 REVERSE TRANSCRIPTASE HOMOLOG 128 5324 10456 0.5 3.OOE-16 AW022862.1 EST-HUMAN df45c01.yl Morton Fetal Cochlea Horno sapiens cDNA done IMAGE:2486376 5' 128 5324 10457 0.5 3.OOE-16 AW022862.1 EST HUMAN df45c01.yl Morton Fetal Cochlea Homo saplens cDNA done IMAGE:2486376 5' 458 5624 1.5 3.OOE-16 AL046445.1 EST HUMAN DKFZp434P037-rl 434 (synonym: htes3) Homo sapiens cDNA done DKFZp434P037 5' 467 5632 0.6 3.OOE-16 AF135446.1 NT Homo sapiens TSX (TSX) pseudogene, exon 5 1436 6563 11739 0.7 3.OOE-16 028983 SWISSPROT ZONADHESIN PRECURSOR 2946 8097 13202 4.1 3.0012-16 P03200 SWISSPROT ENVELOPE GLYCOPROTEIN GP340 (MEMBRANE ANTIGEN) (MA) [CONTAINS:

GLYCOPROTEIN GP2201 3756 8894 13985 1.1 3.OOE-16 BE252133.1 EST HUMAN 601113712F1 NIH MGC 16 Homo saplens cDNA clone iMAGE:3354291 5' 3874 9010 8.2 3.OOE-16 AF020503.1 NT Homo sapiens FRA3B common fragile region, diadenosine triphosphate hydrolase (FHIT) gene,exon 5 3875 9011 1.0 3.OOE-16 U03887.1 NT Human BXP20 gene 956 6102 1,2 2.00E.W AL163279.2 NT Homc, saplens chromosome 21 segment HS21 C079 2337 7439 1.0 2.OOE-16 AA621761.1 EST HUMAN af06d04.si Soares tesdsLNHT Homo sapiens cDNA done IMAGE:1030855 3' 2657 7746 0,6 2.OOE-16 J03061.11 NT Human SSAV-related endogenous retroviral LTR-like element 4087 9213 14296 1,3 2.OOE-16 X8921 1.1 NT H.sapiens DNA for endogenous retroviral like element 178 5371 10495 0.9 1.OOE-16 AF20071 9.1 NT Homo sapiens pituitary tumor transforming gene protein (PTTG) gene, complete cds 377 5583 7.6 1.OOE-16 AA628592.1 EST HUMAN af39gi I.sl Soares total fetus_Nb2HF_gw Homo sapiens cDNA done IMAGE:1 034084 X similar to contains 5FR.22 OFR repetitive element; 4345 9468 14556 1.2 1.OOE-16 P10272 SWISSPROT POL POLYPROTEIN [CONTAINS: PROTEASE; REVERSE TRANSCRIPTASE; ENDONUCLEASE) 3679 8818 13911 2.5 9.OOE-17 AW900048.1 EST HUMAN CM1-NW003-200300-153- e01 NNI003 Homo sapiens cDNA 1001 6141 0,6 8.00E717 AW880701.1 EST HUMAN QVO-OT0032-080300-155-d01 OT0032 Homo saplens cDNA 3817 8954 0.9 8ME-1 AL163280.2 NT tiomo sapiens chromosome 21 segment HS21 C080 959 6104 11262 0.9 7.OOE-17 Q91081 SWISSPROT ALPHA-2 ADRENERGIC RECEPTOR (ALPHA-2 ADRENOCEPTOR) 1442 6569 1.2 7.OOE-17 6753097 NT Mus musculus apollpoproteln B editing complex 2 (Apobec2), mRNA 5390 10518 1.6 6.OOE-17 AW983880.1 EST HUMAN _ RC1-1-IN0003-220300-021-b04 HNO003 Homo sapiens cDNA Page 78 of 196 Table 4

T HUM-AN 5h08xl strata one lung (#93721 Horno sa lens, cIDNA done 1 GE:79839 5 415 5204 10305 0.8 5.OOE-17 T64110.1 E _, 0.9 -Z-.O-OF--17BE315238.1 EST HUMAN 601141631F1 N1H MGC 9 Homo samens cur4A done IMAGE:3141678 5' 2413 7512 12719 27-1- 1-2368 1,4 '-YO-OE-17 AW119123.1 1EST L 1HomoslapiensDNA done IMAGIE:2604784 3' 051 63 ---,'-HUMAN 7d-89cog.x,i Soares NF T GBC 51 SWISSPROT MAS-RELATED G P1 3157 8306 1.3 3.OOE-17 P35410 ZOTErN-COUPLED RECEPTOR MRG 8729 1-3825 1-1 _3.0012-17 2E326522.1 EST HUMAN hWD5b04.xl NCI WAR-Lu24 Horno 3E,1"a"lllllllpienc; curiA done IMAGE:3181999 3' c05h08 r' Strata '1 1 4' 631 F' N1H d89c09 xl Scares MAS-RELATED G 1 hw 5 0 xl Cl C () b 0 O4N W 5 xl Cl C hwO5b04.xl Lu 3590 8729P3 2266 1.1 3.0OE-117 BE326522.11 ES:rHUMAN h b 4. N 24 Homo wii Wens cDNA clone IMAGE:3181999 3' 3 t 0 a06 xl Cl C(, done IMAGE:1959922 3. similar to Cl 8 qt63a06.xl NCI-PGAP_pso2 Horno saplens cuNA q 3. N _ 350 5531 10659 1.0 2.OOE-17 A1270080.1 EST HUMAN contains Alu repetitive element; 51ss a 51.................. AP Eso2 Homo 1959922 31 similar to 1 D3 sapiens cl)1115. done IMAGE nRsq 2.OOE-17 A127 EST HUMAN contains Alu repetitive element; 351 5531 10659 0.7 0080.1 972 61.18 1,3 2.OOE-17 AA722932.1 EST HUMAN z981c104.sl Soares_fetai_ffieart-NbHH19W Homo sapiens cIDNA clone IMAGE:399751 3' 2397 _F49-7 1-2702 0.9 2.OOE-17 Q28983 SWISPROT ONADHESIN PI CURSOR 2397 7497 1270 0.9 2.OOE-17 Q28983 SWISSPROT ZONADHESIN PRECURSOR ZO NNEEUROFILAMENT TRIPLET H PROTEIN (200 KDA NEUROFILAMENT PROTEIN) 2899 8050 13153 5,6 2.OOE-17 P12036 SWISSPROT (NEUROFILAMENT HEAVY POLYPEPTIDE) (NF-H) 4681 9793 14895 1,1 2.OOE-17 P80668 SWISSPROT PHENYLACETALIDEHYDE DEHYDROGENASE PAD) 733 5887 11031 1.2 11.0OE-17- P08183 SWISSPR MULTIDRUG RESISTANCE PROTEIN Y PROTEIN 1) _TB-52 1-2031 0.9 1.OOE-17 1729 AL163207.2 NT Homo s,,)lens chromosome 21 seament HS21 C007 2069 7151 12385 0.6 1.0OE-17 P02461 WiSSPROT - LLAGEN ALPHA 1 (111) eMAIN PRECURSOR - 2287 -75-92 1-2599 0-5 1.0OE-17 U79410.1 NT Homo saplens thrombospondin 2 (THBS2) go e, pro-mar rAninn and exons 1A and 1 B Horno sapiens mannosidase. beta A, lysosomal (MANBA) gene, and ubiquidnconjugaung 3519 8660 1.0 1.0OE-17 AF224669.1 NT enzyme E2D 3 (LIBE2D3) genes, complete cds 4045 9172 7.2 1.OOE-17 R09942.1 EST HUMAN 30e07.rl Scares fetal liver spleen 1NFI.S Homo sapiens cIDNA clone IMAGE:128388 5' 2422 7521 1272128 1.0 9.OOE-18 AA174078.1 EST HUMAN zpI 8gl 2.sl Stratagene fetal retina 937202 Homo sapiens cDNA done IMAGE:609862 3' 8 Homo sapiens protein tyrosine phosphatase, non-receptor type substrate 1 (PT1PNS1) mRNA 3718 8855 1394477 1.8 8.OOE-18 4758977 NT W0b04.xl NCI C AP---PanI Homo saplens eDNA cl no IMAGE:2837071 Ysimilar to n H a n DNA n -GE v le 5 C do 0 lM XX.0b04 GA a 0 5 HU - 0 1 EST_HUMAN gb,L208 0 58977 NT U10b1X -xl NCI -C G P-P 1 OM p 4 6 R B R EIN 346 5527 10653 2.9 7.OOE-18 AW316976.1 gb 0 668 60S RIBOSOMAL PROTEIN 1.4 (HUMAN); U 8 8 OS OSOtML p OT L 0b04 1 1 G _Pan H 0 sa Ion CDNA d no xx10b04 AP P N _C 'W 1 OM p 4 (HU N).

OSO p 1 xl NCI CG anll Horno saplens CUNA clone IMAGE:2837071 Ysimilar to X C b. 0868 6 R R EN EST HUMAN gb1208 1 nA-r%d g. 11 OS B MAL OT L S 1 C t 346 5527 H 68 60S iIBOSOMAL PROTEIN L4 (HUMAN); 2 NT Homo s ts omo sa 2 ens chromwo e2e m nt H 2 4338 9461 @UJU nniAns cDNA done it Iya49c07.sl Soares Infant brain 1N113 1M10mo sapiens cDNA done IMAGE:53285 Ysimilar to 5136 10231 15306 0.9 7.OOE-18 R1 6220.1 EST-HUMAN contains L1 repetitive element; 4491 W1 - '12,00E-18 AL1163268.2 NT M - nmn -q2niens chromosome 21 so _ntHS21C068 PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE (TISSUE 4641 9755 3.4 6.OOE-18 P52181 SWISSPROT TRANSGI-LITAMINASE) (TGASE C) (TGC) 5911.xl Scares -- i; _placent;_8to9weekE_2NbHP8togW Homo sapiens cDNA clone bl 6266tl 1418 _ 5,0 5.OOE-18 A1280214.1 11 MAN 3' similar to contains Alu repetitive element; Page 79 of 196 Table 4

5058 10156 15232 1.8 5.OOE-18 D61517.1 EST-HUMAN HUM41 1 F05B Clontech human fetal brain polyA+ mRNA (#6535) Horno sapiens cIDNA clone GEN-41 1 F05 5' 119 5318 10447 1.4 4.00IE-18 BE044076.1 EST-HUMAN ho36h04.xl NCLCGAP_Utl Homo sapiens c1DNA clone IMAGE:3039511 3' similar to contains MER2913 MER29 repetitive clement; 119 5318 10448 1.4 4.OOE-18 BE044076.1 EST - HUMAN ho36h04.xl NCLCGAP_Utl Horno sapiens cDNA done IMAGE:3039511 Ysimilar to contains MER291S MER29 repetitive element; 1846 6964 1,1 4.OOE-18 A1738592.1 EST HUMAN w133h08.xl NCI_CW Col 6 Homo sapiens cDNA done IMAGE:2392095 X 2154 7264 12472 1.0 4.OOE-18 Q06430 SWISSPROT N-ACETYLLACTOSAMINIDE BETA- 1,6-N.ACEYYLGLUCOSAMINYLTRANSFERASE (N ACETY1-GLUCOSAMINYLTRANSFERASE) fl-BRANCHING ENZYME) (IGNT) 2154 7264 12473 1.0 4.OOE-18 006430 SWISSPROT N-ACETYLLACTOSAMINIDE BETA1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE (W ACETY1-GLUCOSAMINY1-TRANSFERASE) (I-BRANCHING ENZYME) (IGNT) 4793 9904 14997 1.1 4.0012-18 AF1 19668.1 NT Rattus norvegicus lipolysis- stirnulated remnant receptor alpha' subunit mRNA, complete cds 831 5980 11141 0.8 3.OOE-18 AA814196.1 EST-HUMAN ob23h11.sl NCI CGAP K1d5 Horno, sapiens cIDNA clone IMAGE:1324581 Ysimilar to SW:RS5-HUMA- P467i-2 40S RIBOSOMAL PROTEIN S5.; 914 6060 11218 0,8 3.OOE-18 BE088634.1 EST-HUMAN CMO-BT0690-210300-29"07 BT0690 Horno sapiens cIDNA 3867 9F03- 14103 1.2 3.OOE-18 AL163247.2 NT Horno, sapiens chromosome 21 segment HS 1 C047 251 5439 10566 1 60 2.OOE-18 AW836820.1 EST HUMAN QV1-1-TO036-150200-070- e07 LT0036 Horno s2Riens cDNA 1135 6271 16.0 2.0012-18 BE256097.1 EST-HUMAN 601114352F1 NIH MGC 16 Horno sapiens cIDNA done.IMAGE:3355044 5' 2649 7738 12938 1.4 1.OOE-18 A1.163267.2 NT Horno, sapiens chromosome 21 segment HS21 C067 4318 9441 1.0 1.OOE-18 T95406.1 ESTHUMAN ye43905.rl Soares fetal liver spleen 1NFLS Homo saplens c1DNA clone IMAGE:120536 5' similar to contains 1.1 rdpedfive element; 533 5697 10821 1 9.OOE-19 AA281961.1 EST HUMAN ztl 1d06xl NCI - CGAP - GCBI Horno, saplens cIDNA done IMAGE:712811 Tsimilar to contains MER19.t2 MER19 repetitive element; 534 5697 10821 1.1 9.OOE-19 AA281961.1 EST-HUMAN zt11d06xl NCI - CGAP - GCBI Horno sapiens cDNA done IMAGE:712811 Tsimilar to contains MER1 9.t2 MER1 9 repetitive clement; 1032 6172 0.5 8.OOE-19 AW974902.1 EST HUMAN EST387007 MAGE resequenoes, MAGN Horno sapiens cIDNA 4266 9Y9-1 14474 2.7 8,00IE-19 AW902939.1 EST HUMAN CIV3-NW 025-100500183-b01 NN1 025 Horno saplens cDNA 2198 7307 12519 0.6 7.OOE-19 4758139 NT Horno sapiens DEAD/H (Asp-Glu-Ala- Asp/His) box polypepfide 6 (RNA helicase, 540) (DDX6) mRNA 3713 8851 1.0 6.00IE-19 AW852930.1 EST HUMAN PMO-CTO248-131099-001-901 CTO248 Homo sapiens eDNA 4360 9482 14573 1.4 6.OOE-19 P34986 SWISSPROT OLFACTORY RECEPTOR 6 (M50).

4360 W2 14574 1.4 6.OOE-19 P34986 SWISSPROT OLFACTORY RECEPTOR 6 (M50) 4694 9806 1.2 6.OOE-19 AJ271735.1 NT - Horno sapiens Xq pseudoautosornal region; segment 112 4952 10057 15127 1.1 6.OOE-19 AL120817.1 EST HUMAN DI(FZp762F1192-rl 762 (synonym: hme12) Horno sapiens c1DNA clone DKFZp762F1 92 5, 542 5705 10825 1.5 4.OOE-19 AB007970.1 NT Horno sapiens mRNA, chromosome 1 specific transcript KIAA0501 3778 8915 14007 1.7 3.OOE-19 Q28997 SWISSPROT BETA-2 ADRENERGIC RECEPTOR 3778 8915 14008 1.7 3.OOE-19 Q28997 SWISSPROT BETA-2 ADRENERGIC RECEPTOR 2513 7609 12811 6.4 2.OOE-19 A1.163201.2 NT Horno, sapiens chromosorne, 21 segment HS21 C001 473 5639 1.OOE-19 BE40861 1.1 EST-HUMAN 601304125F1 NIH MGC 21 Homo sapiens cIDNA done IMAGE:3638310 5' Page 80 of 196 Table 4

2118 7229 12438 0.5 1.0OE-19 H30795.1 EST HUMAN yo79g07xl Soares adult brain N2b4H1355Y Homo sapiens cIDNA done IMAGE: 184188 5' similar to contains MER10 repetitive element; 2685 7772 1.0 1.OOE-19 D38044.1 NT Human gene for Ah-receptor, exon 7-9 2817 7968 5.0 1.00EAQ 4758977 NT Homo saplens protein tyrosine phosphatase, non-receptor type substrate 1 (12TPNS1) mRNA 3355 8498 13607 1.3 1.0OE-19 AA834967.1 EST HUMAN aj49bl2.sl Soares tesfis NHT Homo sapiens cDNA done IMAGE:1393631 3'sImIlar to contains MER37.jMER:7 repetitive element; 4626 9740 14837 1.3 8.OOE-20 H68656.1 EST HUMAN yr87h12xl Soares fetal liver spleen 1NFI-S Homo sapiens cIDNA done IMAGE:212327 5' 3508 8649 13759 3.9 6.OOE-20 P39188 SWISSPROT ALU SUBFAMILY J SEQUENCE CONTAMINATION WARNING ENTRY 2092 7203 12408 1.0 3.OOE-20 U03888.1 NT Human BXP21 gene 4115 W71 14327 1.7 3.OOE-20 P23273 SWISSPROT OLFACTORY RECEPTOR-LIKE PROTEIN 114 4524 9643 14733 0.9 3.OOE-20 AA037616.1 EST HUMAN zk36b12.sl Soares_pregnanLuterus_NbHPU Homo saplens cDNA done IMAGE:484895 X similar to contains Ll.t3 L1 repetitive element; 813 5963 1.5 2.OOE-20 AW303868.1 EST-HUMAN xr24e10.xl INICI_WAP_U1:4 Homo saplens cDNA done IMAGE:2761098 Ysimilar to SW:RSMOUSE P97461 405 RIBOSOMAL PROTEIN S5.; 1095 6233 11384 0.7 2.OOE-20 AA516335.1 EST-HUMAN ng69h09.sl NCI-CLip2 Homo saplens cIDNA, done IMAGE:940097 similar to TR:G1224066 G1224066 ORF2: FUNCTION UNKNOWN.; 1095 6233 11385 0.7 2.OOE-20 AA516335.1 EST HUMAN n969h09.sl NCI_PGAP - 102 Homo sapiens cIDNA done IMAGE:940097 similar to TR:G1224066 G1224066 ORF2: FUNCTION UNKNOWN.; 2173 7282 12495 0.6 2.OOE-20 H68656.1 EST-HUMAN yr87h12xl Soares fetal liver spleen 1NFI-S Homo sapiens cIDNA clone IMAGE:212327 5' 2786 5963 0.9 2.OOE-20 AW303868.1 EST-HUMAN xr24e10.xl NCI - CGAP - Ut4 Homo sapiens cDNA done IMAGE:2761098 Ysimilar to SW:RS_MOUSE P97461 40S RIBOSOMAL PROTEIN SS.; 4866 9973 15057 4.3 2.OOE-20 Q28983 SWISSPROT ZONADHESIN PRECURSOR 4866 9973 15058 4.3 2.OOE-20 Q28983 SWISSPROT ZONADHESIN PRECURSOR 5090 10188 11.4 2.OOE-20 5174538 NT Homo saplens malate dehydrogenase 1, NAD (soluble) (MIDH1) mRNA 1967 7870 12283 1.9 1.0012-20 AA281961.1 EST HUMAN zM 1 d06.0 NCI_QGAP_GCB1 Homo sapiens cIDNA, clone IMAGE:712811 5' similar to contains MER19.t2 MER19 repetitive element; 4764 9875 14970 1.0 1.OOE-20 7661767 NT Homo sapiens HSPC064 p In (HSPC064), mRNA 308 5492 10621 1.0 9.OOE-21 BE165641.1 EST HUMAN CM4-HT0481-310100-085- d07 HT0481 Homo sapiens cONA 2883 8034 1.1 9.0012-21 AJ003514.1 EST HUMAN AJ003514 Selected chromosome 21 cIDNA library Homo sapiens cIDNA done MP1p112-8J21 172 5365 10490 1.0 8.OOE-21 A1795842,1 EST HUMAN RCO-HT0023-300699-001- EG4 HT0023 Homo saplens cIDNA.

172 5365 10491 1.0 8.OOE-21 A1795842.1 EST HUMAN RCO-HT0023-30069M01-E04 HT0023 Homo splens cIDNA 2023 7136. 12335 0.8 7.OOE-21 P15800 SWISSPROT LAMININ BETA-2 CHAIN PRECURSOR (S.LAMININ) (LAMININ CHAIN B3) 2023 7136 12336 0.8 7.OOE-21 P15800 SWISSPROT LAMININ BETA-2 CHAIN PRECURSOR (S.LAMININ) (LAMININ CHAIN B3) 416 1 9287 5.0 7.0012-21 AA046502.1 EST HUMAN zk67a06xl Soares_pregnant- uterus-NbHPU Homo sapiens cDNA done IMAGE:487858 5, 4014 9145 14228 0.9 6.OOE-21 BE40861 1.1 EST HUMAN 601 304125F1 N1H MGC 21 Homo saplens cIDNA done IMAGE:3638310 5' 907 6053 0.6 5.OOE-21 5902031 NT Homo sapiens protein tyrosine phosphatase, non-receptor type 21 (PTPN21), mRNA Page 81 of 196 Table 4

2234 7341 12553 1.1 5.OOE-21 AA928194.1 EST_HUMAN om23g03.sl Soares_NFLj_GBC._Sl Homo sapiens cDNA clone IMAGE:1541908 Ysimilar to TR:002711 002711 PRO-POL-DUTPASE POLYPR6TEIN:

4696 9808 14907 6.0 5.OOE-21 4885474 NT Horno saplens melanorna antigen, family C, 1 (MAGEC1), mRNA 5109 10205 1.0 5.OOE-21 D87675.1 NT Homo sapiens DNA for amold precursor protein, complete cds 1701 6824 12005 1.2 4.OOE-21 AA970713.1 EST-HUMAN oo86e08.sl NCLCGA12-KI0 Homo sapiens cDNA done IMAGE: 1573094 3'similar to TR:Q116530 Q16530 PMS3 IVIRNA;contains OFR.0 OFR repetitive element; 2228 7335 12547 1.1 3.0OE-211 AL163201.2 NT Homo sapiens chromosome 21 segment HS21C001 3041 8192 13294 4.0 3.OOE-21 AJ007973.1 NT Horno saplens LGMD2B gene 5336 5.0 2.OOE-21 BE163247.1 EST_HUMAN OV3-HT0458-170200-090-912 HT0458 Homo sapiens cDNA 919 6065 11220 0.9 2.OOE-21 AB007857.2 NT Horno sapiens mRNA for KIAA0397 protein, partial cds 919 6065 11221 0.9 2.OOE.21 ABOO7857.2 NT Homo saplens mRNA for KIAA0397 protein, partial cds 1164 6299 11454 2,6 2.OOE-21 AA206749.1 EST-HUMAN zq79b11 11xl Stratagene hNT neuron (#937233) Homo sapiens oDNA done IMAGE:647805 5' similar to SW:YGA1 YEAST P48234 HYPOTHETICAL 81,7 KD PROTEIN IN MOLI-NAT2 INTERGENIC REGIN. [11; 1196 6328 0.7 2.OOE-21 BE064410.1 EST HUMAN RC4-BT03111-1141 199-011 -h06 OT0311 Honno sapiens cDNA 2260 7366 12575 2.6 2.OOE-21 D14547.1 NT Human DNA, SINE repetitive element 2516 7612 12814 0.8 2.OOE-21 T1 0311.1 ES-_HUMAN seq1487 b41-IB3MA Cot8- HAP-Ft Homo sapiens cDNA clone b4HB3MA-COT8-HAP-Ft259 5' 2599 7690 12893 1.0 2.OOE-21 Q28983 SWISSPROT ZONADHESIN PRECUR R 2599 7690 12894 1.0 2.OOE-21 Q28983 SWISSPROT ZONADHESIN PRECURSOR 1235 6364 11526 0.6 1.OOE-21 AA557657.1 EST-HUMAN n[4.sl NCI-CGAP_Pr4 Homo saplens cDNA done IMAGE:1043718 similar to contains MER2912 MER29 repetitive element; 1381 6508 0.9 1.OOE-21 A1601264.1 EST HUMAN ar88d12.xl Barstead colon HPI- RS7 Horno sapiens cIDNA done 1 MAGE:2152343 3' 4312 9435 14525 2.6 9.OOE-22 A1702438.1 N tz94a03.xl NCLWAP---Kidl 1 Homo saplens cDNA done IMAGE:2296204 3'sImilar to TR:015408 Q15408 NEUTRAL PROTEASE LARGE SUBUNIT; 933 6080 1.6 8.OOE-22 BE144748.1 EST HUMAN CMO-HT0179-281099-076-h05 HT0179 Horno saplens cDNA 649 5807 10933 1.4 7.OOE-22 AL163246.2 NT Homo sapiens chromosome 21 segment HS21C046 4186 9312 14393 2.3 7.OOE-22 Q61838 SWISSPROT ALPHA-2-MACROGLOBLILIN PRECURSOR (ALPHA2M) 4969 10072 15145 1.2 7.OOE-22 ABOO8681.1 NT Homo saplens gene for actIvin receptor type JIB, complete cds 3584 8723 0.9 4.OOE-22 AJ271735.1 NT Homo saplens Xq pseudoautosonnal region; segment 112 943 6090 1.2 3.OOE-22 A1469679.1 EST HUMAN 1m14h110.xl NCI - WAP---Co14 Homo sapiens cDNA done IMAGE2156611 3'similar to 9b119593 HIGH AFFINITY INTERLEUKIN-8 RECEPTOR B (HUMAN);contains Ll.tl L1 repetitive element; 2523 7619 12820 0.7 3.OOE-22 A1859038.1 EST-HUMAN YA66b04.xl NCLWAP-13m25 Honno saplens cDNA clone IMAGE:2429839 3' similar to SW:R1-21-HUMAN P46778 60S RIBOSOMAL PROTEIN L2l.; 3620 8759 1.5 3.OOE-22 D14718.1 - NT Human chromosomal protein HIVIG11 related gene 4212 9336 14419 0.8 3.OOE-22 F00548.1 EST HUMAN HSB1OE082 STRATAGENE Human skeletal muscle cDNA library, cat. #936215. Honno saplens cDNA clone 10E08 4212 9336 14420 n Q BIOE082 STRATAGENE Human skeletal muscle cDNA library, cat. #936215. Honno ilens cONA done 1 0E08 Page 82 of 196 Table 4

4695 9807 14906 2.7 3.OOE-22 A1090125.1 EST-HUMAN qb28c07xl SoaroMregnantuterus_NbHPU Horno sapiens cDNA clone IMAGE:1697580 3' similar to contains MER12.1:2 MER12 repetitive element; 1910 7027 1.0 2.OOE-22 N24942.1 EST-HUMAN W3d05.si Soares melanocyte 2NWM Homo sa_plens eDNA done IMAGE:267369 3' 2476 7574 12776 1.3 2.OOE-22 P24916 SWISSPROT IMMEDIATE EARLY GENE 13 PROTEIN PRECURSOR 3373 8516 13623 4.1 2.OOE-22 8394043 NT Homo sapiens protein kinase, AMP- acdvated, gamma 3 non-catalydc subunit (PRKAG3), mRNA 3587 8726 13822 0.9 2.OOE-22 R58726.1 EST - HUMAN G4789 Fetal heart Homo sapien6 CIDNA done G4789 V end 4133 9259 14340 1.3 2.OOE-22 AW817794.1 EST HUMAN PM1-ST0262-261199-001- d12 ST0262 Homo saplens cDNA 63 5271 10393 0.8 1.OOE-22 AW886543.1 EST HUMAN RC1-OT0083-220300-021-c07 OT0083 Homo saplens cDNA 63 5271 10394 0.8 1.OOE-22 AW886543.1 EST-HUMAN RC1-OT0083-220300-021-c07 OT0083 Homo sapiens cDNA 1836 6955 12141 0.6 1.OOE-22 AW865517.1 EST_HUMAN PM4-SNO020-010400-009- h02 SNO020 Homo sapiens cDNA 2400 7943 0.5 1.0OE-22 AA199812.1 E 1 S-f_HUMAN zq76M I.rl Stratagene hNT neuron (#937233) Homo sapiens cDNA done IMAGE:647565 6 similar to SWVPRT_HUMAN P10265 RETROVIRUS-RELATED PROTEASE:

2539 7635 12835 1.0 1.OOE-22 U50871.1 NT Human familial Akhelmer's disease'(STM2) gene, complete cds 3365 8508 13616 1.7 1.OOE-22 D14547.1 NT Human DNA, SINE repetitive element 3523 8664 13768 0.8 8.0012-23 AF198349.1 NT Gallus gallus Dach2 protein (Dach2) mRNA, complete cds 2800 6795 11971 1.8 7.OOE-23 AA189080.1 EST-HUMAN zq45b06.sl Stratagene hNT neuron (#937233) Homo saplens cDNA done IMAGE:632627 X similar to contains Alu repetitive element; 3387 8530 1.6 6.OOE-23 AF199333.1 NT Rattus norvegicus RIM1 B (Riml B) mRNA,'complete cds 4171 9297 14378 3.1 6.OOE-23 AL163249.2 NT Homo sapjens chromosome 21 segment HS21 C049 660 5808 10934 1.5 2.6OE-23 AJ289880.1 NT Horno sapiens KIAA0851 gene Eardal), XT3 gene and LZTFL1 gene 1126 7866 0.9 2.OOE-23 M55270.1 NT Human matrix Gla protein (MGP) gene, complete eds 2765 7849 13051 1.1 2.OOE-23 P22105 SWISSPROT TENASCIN-X PRECURSOR (TWX) (HEXABRACHION-LIKE) 2765 7849 13052 1.1 2.OOE-23 P22105 SWISSPROT TENASCIN-X PRECURSOR (TWX) (HEXABRACHION-LIKE) 3325 8469 1.5 2.OOE-23 A1201458.1 EST HUMAN qs73M 1.xl NCI_CGAP_Pr28 Homo sapiens cDNA done IMAGE:1943757 Ysimilar to TR:Q13537 Q13537 MER37 TRANSPOSABLE ELEMENT, COMPLETE CONSENSUS SEQUENCE.; 3655 8794 3.0 2.OOE-23 SE165980.1 EST HUMAN MR3-HT0487-150200-113-901 HT0487 Homo sapiens cDNA 3894 9029 14121 3.0 2.OOE-23 H59931.1 EST-HUMAN yr16a02xl Scares fetal liver spleen 1NFI-S Horno sapiens cDNA done IMAGE:2b5418 5' 3894 9029 14122 3.0 2.OOE-23 H59931.1 EST HUMAN yd 6a02.rl Soares fetal liver spleen 1 NFLS Homo saplens cDNA clone IMAGE:205418 5' 4428 9549 14642 1.6 1.OOE-23 AL163252.2 NT Homo saffiens chromosome 21 segment HS21 C052.

4657 9769 4.5 1.OOE-23 AL163210.2 NT Homo sapiens chromosome 21 segment HS21C010 540 5703 0.6 9.OOE-24 AA663213.1 EST-HUMAN ab75a0B.sl Stratagene fetal retina 937202 Homo saplens cDNA clone IMAGE:852758 3 similar to TR:E19822 E19822 CA PROTEIN.; 4549 9668 14757 1.1 8.OOE-24 P23269 SWISSPROT OLFACTORY RECEPTOR-LIKE PROTEIN 13 4549 9668 14758 1.1 6,OOE-24 P23269 SWISSPROT OLFACTORY RECEPTOR-LIKE PROTEIN 13 3796 8933 1.3 7.OOE-24 AW937954.1 EST-HU N QVO-DT0047-170200-122-a06 DT0047 Homo sapiens cDNA 690 5845 0.8 6.OOE-24 AB001421.1 NT Macaca fuscata mRNA for Tesds-Spedfic Protein Y (TSPY), complete ods IZIC) Page 83 of 196 Table 4

820 5970 11127 3.5 6.OOE-24 AL163249.2 NT Homo sapiens chromosome 21 segment HS21 C049 4068 9195 14278 2.1 6.0012-24 AF199333.1 NT Rattus norvegicus RIM1 B (RimI B) mRNA, complete ods 4068 9195 14279 2.1 6.OOE-24 AF199333.1 NT Rattus norvegicus RIMIB (Riml B) mRNA, complete ods 3889 9025 14117 7.2 5.OOE-24 AJ229043.1 NT Homo sapiens 959 kb config between AM1.1 and CBR1 on chromosome 21q22, segment 313 2298 7402 12610 0.8 2.OOE-24 AA1 67539.1 EST-HUMAN zpl 1 f09xl Stratagene fetal retina 937202 Horno sapiens cIDNA clone IMAGE:609161 W 3216 8364 13475 1.0 2.OOE-24 AA293827.1 EST - HUMAN zt65b06xl Soares tesds_NHT Homo sapiens cIDNA done IMAGE:727187 5, 3729 8866 1.0 2.OOE-24 AW898189.1 EST HUMAN RC3-NNO068-090500-021-b03 NNO068 Homo sapiens cDNA 1670 6794 11970 0.8 1.OOE-24 7706340 NT Homo sapiens CGI-127 protein (LOC51646), mRNA 2638 7727 0.7 1.OOE-24 AW820194.1 EST-HUMAN OVO-ST0294-100400-185-cl 0 ST0294 Homo sapiens cDNA 2987 8139 13242 0.9 1.OOE-24 D86423.1 NT Mus musculus mRNA for HGT keratin, partial cds 4173 9299 1,6 1.0OE-24 AF143313.1 NT Homo sapiens PTEN (PTEN) gene, exon 2 4926 10033 15107 2.3 7.OOE-25 AA483944.1 EST-HUMAN ne92el 0.sl NCI- PGAP_Kidl Homo sapiens cIDNA clone IMAGE:91 1754 similar to contains MERI.b2 MER1 repetitive element; 4710 9822 5.5 6.OOE-25 039575 SWISSPROT DYNEIN GAMMA CHAIN, FLAGELLAR OUTER ARM 5166 10260 15331 1,0 5.OOE-25 AW838171.1 ES1_HUMAN QV2-LT0051-260300A 11403 LT0051 Homo sapiens cDNA 1430 6557 11733 0,8 4.OOE-25 T98107.1 EST_HUMAN ye56h04xl Soares fetal liver spleen 1NFLS Homo sapiens eDNA done IMAGE:121783 5' 3356 8499 2.8 4.OOE-25 AW887671.1 EST HUMAN PM3-OT0093-280200-001 -g07 OT0093 Homo sapiens cDNA 3979 9111.14193 0.8 4.OOE-25 7106446 NT Mus musculusMngless-related MMTV Integration site 3A (3a), mRNA 3979 9111 14194 0.8 4.OOE-25 7106446 NT Mus musculus vAngless-related. MMTV Integration site 3A (Wnt3a), mRNA 4221 9345 3.0 4.OOE-25 BE170957.1 EST-HUMAN QV3-HT0543-140400-149-el 1 HT0543 Homo sapiens eDNA 3278 8423 13531 2.7 3.OOE-25 8923321 NT Homo sapiens hypothetical protein FLJ20344 (FU20344), mRNA 3278 8423 13532 2.7 3.OOE-25 8923321 NT Homo sapiens hypothetical protein FLJ20344 (FU20344), mRNA 4798 9909 15002 0.9 3.OOE-25 P29622 SWISSPROT KALLISTATIN PRECURSOR (KALLIKREIN INHIBITOR) (PROTEASE INHIBITOR 4) 1325 6454 11620 1.2 2.OOE-25 5032158 NT Homo sapiens transducin (betailke 1 (TBLI) mRNA 2363 7465 12670 1.3 2.OOE-25 AW954060.1 ESTHUMAN EST366130 MAGE resequences, MAGC Horno saplens cDNA 2801 7592 12795 1,6 2.OOE-25 P17008 SWISSPROT 40S RIBOSOMAL PROTEIN 816 4096 9222 14305 1.9 2.OOE-25 P17008 SWISSPROT 40S RIBOSOMAL PROTEIN S19) 4096 9222 14306 1.9 2.OOE-25 P17008 SWISSPROT 40S RIBOSOMAL PROTEIN S16 361 5539 10670 0.6 1.OOE-25 AL040229.1 EST HUMAN DI(FZp4341-10313-rl 434 (synonym: htes3) Homo sapiens cDNA clone DKFZp4341-10313 5, 2384 7486 12688 2.8 1.OOE-25 Q06055 SWiSSPROT ATPSYNTHASE LIPID-BINDING PROTEIN P2 PRECURSOR (ATPASE PROTEIN 9) (SUBUNIT C) 4753 9864 14957 2.7 1.OOE-25 BE162737.1 EST HUMAN PM1-HT0454-080100-002h09 HT0454 Homo sapiens cDNA 2433 7532 12738 0.7 9.OOE-26 AL-163218.2 NT Homo sapiens chromosome 21 segment HS21 C01 8 6686 11853 0.5 7.OOE-26 AF003528.1 NT Homo sapiens X-linked anhidroitic ectodermal dysplasia protein gene (EDA), exon 2 and flanking repeat regions 3898 9033 14126 1.4 7.OOE-26 X8921 1.1 NT H.sapiens DNA for endogenous retroviral like element 4067 9194 14277 2.0 7.OOE-26 AW340153.1 EST-HUMAN W02e12.xl Soarep_NFLjl_GBC S1 Homo saplens cDNA done IMAGE:2908366 3' Page 84 of 196 Table 4

Homo sapiens chromosome 9 duplication of the T cell receptor beta locus and trypsinogen 2178 7287 12499 0.9 6.OOE-2-6 AF029308.1 NT oene families zq52h04.M Stratagene neuroepithellum (#937231) Homo sapiens cDNA clone 3302 8447 13557 1.4 6.OOE-26 AA206131.1 EST HUMAN IMAGE:645271 5' HPI-RI216 Horno sapiens cDNA done IMAGE:2319519 Ysimilar to as38h08.xl Barstead aorta 1160 6295 11450 1.1 5.OOE-26 A1708235.1 EST HUMAN WIP:1X49C12.11 CE03371; aorta HPI-RI36 Homo sapiens cIDNA done IMAGE:2319519 3'simiiar to as38h08.xl Barstead 1160 6295 11451 1.1 5.OOE-26 A1708235.1 EST HUMAN WIP:F49C12.11 CE03371; specificity factor mRNA, complete cels 2692 7779 12976 1.8 5.0OE-26 U37012.1 NT Human cleavage and polyadenylation 11 Homo sapiens cDNA Vend 1525 665-2 12272 1.5 4.OOE-26 AA329548.1 EST_HUMAN EST33446 Embryo, 12 week 1958 7075 0.5 3.OOE-26 AL045855.2 EST HUMAN DI(FZp4341066 rl 434 (synonym: htes3) Homo sapiens cDNA done DKFZ 341066.5' neuroeplthellum NT2RAMI 937234 Homo sapiens d3NA done zn30d08.rl Stratagene IMAGE:548943 5'simliar to 9b014338 VITAMIN K-DEPENDENT PROTEIN S 1987 7102 0.9 3.OOE-26 AA1 15895.1 EST_HUMAN PRECURSOR(HUMAN); colon (#937204) Horno sapiens cDNA done IMAGE:588427 5'sImilar 3712 8850 13940 1.2 3.OOE-26 AA1 52464.1 EST HUMAN zo30f10xl Stratagene to TR:G695374 G695374 THYROID RECEPTOR INTERACTOR; colon (#937204) Homo sapiens cDNA done IMAGE:588427 Ssimilar 3712 8850 13941 1.2 3.OOE-26 AA1 52464.1 EST-HUMAN zo30f10xl Stratagene to TR:G695374 G695374 THYROID RECEPTOR INTERACTOR; 21 HS21C082 666 5622 10950 1.9 2.OOE-26 AL163282.2 NT Homo sapiens chromosome 1825 6944 13456 1.2 2.OOE-26 AL038099.2 EST HUMAN segment 3193 8 4.3 2.OOE-26 X86694.11 NT DI(FZp5661-1 71-pl 566 (synonym: hfkd2) Homo sapiens cDNA done DKFZp5661-1 713' M.musculus mRNA for astrocytic phosphoprotein, PEA-15 cDNA HT0538 Horno 132 5328 10459 0.8 1.0OE-26 BE170371.1 EST HUMAN QV4-HT0538-020300-123a02 sapiens 2001 7116 12318 1.4 1.OOE-26 AL039363.2 EST HUMAN DKFZp4341-11 91 0rl 434 (synonym: htes3) Horno saplens cDNA clone DKFZp4341-1 1910 5' 2654 7743 6.1 1.OOE-26 7669491 NT Homo saplens gly"ralge-hyoe-3-phosphate dehydrogenase (GAPD), mRNA Homo sapiens cDNA done IMAGE:2406150 3'similar to 5218 10319 1.1 8.0OE-27 A1831462.1 E HUMAN md49c04.xl NCI---CGAIRJ1-09 545 5708 1.4 8.OOE-27 AL163227.2 NT contains THR12 THR repetitive element; Horno sapiens chromosome 21 segment HS21 C027 fetal brain 00004 Homo sapiens cONA clone IMAGE:2783295 X 1395 6522 11t 6.8 8.OOE-27 AW162737.1 -EST HUMAN au87h08.xl Schnelder 11690 similar to gb:K00558 TUBULIN ALPHA-1 CHAIN (HUMAN); fetal brain 00004 Homo sapiens cDNA clone IMAGE:2783295 X 1395 6522 11691 6.8 8.OOE-27 AW162737.1 EST HUMAN au87h08.xl Schnelder similar to gb:K00558 TUBULIN ALPHA-1 CHAIN (HUMAN); SNO018 Homo sapiens cDNA 2121 7231 12,441 1.0 8.OOE-27 AW864776.1 EST HUMAN PM2-SNO0118-220300-002- a07 PROTEIN, LIVER ISOFORM T2 (ADPIATP TRANSLOCASE 3) AD12.ATP CARRIER 3148 8297 13406 3.3 8.OOE-27 P12236 SWISSPROT (ADENINE NUCLEOTIDE TRANSLOCATOR 3) (ANT 3) 3309 8454 13567 0.9 8.OOE-27 AF181897.1 NT Homo saplens WRN (WRN) gene, completwcds 668 5824 1.2 7.OOE-27 Z70664.11 NT Human endogenous retroAral element HC2 Jone IMAGE:2975879 Ysimilar _$1 Homo sapiens cDNA c 5023 10124 2.1 7.OOE.27 AW629172.1 EST HUMAN h151h12.xl Soarai_NFL,._GBC to TR:076040 076040 ORF2: FUNCTION UNKNOWN.:

RYA3 mRNA fora potential ligand-binding protein 1995 7111 12314 2.0 3.OOE-27 X606M.1 NT - R.rattus Page 85 of 196 Table 4

4174 9300 14381 1.3 3.OOE-27 BE071924.1 EST HUMAN PMO-BT0527-0901 00-001dl 1 BT0527 Homo saplens cDNA 36 5245 10352 8.0 2.OOE-27 AF054187.1 NT Homo sapiens alpha NAC mRNA, complete cds 1853 6971 6.7 2.OOE-27 AA565345.1 EST-HUMAN nkOlblO.sl NCLCGAP_Prl 1 Homo sapiens cDNA done IMAGE:1000699 similar to gb:M17886 60S ACIDIC RIBOSOMAL PROTEIN P1 (HUMAN); 3071 8222 10.3 2.OOE-27 AW629172.1 EST - HUMAN h151h12.xl SoareNFGBC_Sl Homo sapiens cDNA done IMAGE:2975879 3'similar to TR:076040 076040 ORF2: FUNCTION UNKNOWN.; 3187 8336 13448 1.4 2.OOE-27 AF1 11167.2 NT Homo sapiens jun dinterization protein gene, partial cds; dos; gene, complete cds, and unknown gene 3187 8336 13449 1.4 2.OOE-27 AF1 11167.2 NT Homo sapiens jun dimerization protein gene, partial ods; dos; gene, complete cds; and unknown gene 3944 9077 14159 1.1 2.OOE-27 AF000368.1 NT Rattus norvegicus voltage- gated sodium channel mRNA, complete ods 429 5596 0.5 1.0012-27 AL163246.2 NT Homo sapiens chromosome 21 segment HS21 C046 980 6125 11281 1.4 1.0012-27 A13026898.1 NT Homo sapiens DNA, DLEC1 to ORCTL4 gene region, section 112 (DI-EC1, ORCTIL3, ORCTIL4 genes, complete cds) 1438 6565 11742 2.8 1.OOE-27 AF029308.1 NT Homo sapiens chromosome 9 duplication of the T cell receptor beta locus and trypsinogen gene families 136 5331 0.8 9.OOE-28 BE348399.1 EST HUMAN hw11 7c11 1.xl NCLCGAP-LU24 Homo sapiens cDNA done IMAGE:3183188 Ysimilar to TR:Q073114 Q07314 SECRETED NEUREXIN Ill-ALPHA-C PRECURSOR. 131 TR:Q07280 TR:Q073113; 1140 6276 11428 1.1 9.OOE-28 W23234.11 EST HUMAN 81132 Human retina cDNA Tsp5091-cleaved sublibrary Horno sapiens cDNA not directional 5118 10214 15292 1.2 9.OOE-28 A1590115.1 EST HUMAN to12b09.xl NCI--- CGAP_Ut2 Horno sapiens cDNA done IMAGE:2178809 3'similar to contains OFR.M OFR repetitive element; 5118 10214 15293 1,2 9.OOE-28 A1590115.1 EST HUMAN to112b09.xl NCI - WAP_W Homo saplens cDNA done IMAGE:2178809 Ysimilar to contains OFR.tl OFIR repetitive element., 3987 9119 14202 1.3 6.OOE-28 AB020673.1 NT Homo saplens mRNA for KIAA0866 protein, complete cds 3987 9119 14203 1.3 6.OOE-28 A13020673.11 NT Horno saplens mR_NA for KIAA0866 protein, complete cds 315 5499 1.1 5.OOE-28 A1921003.11 EST-HUMAN wol 8c07.xl NCI CGAP Panll Homo saplens cDNA done IMAGE:2455692 Ysimilar to contains THR.b-THR repetitive element; 3927 9061 14148 1.9 5.0012-28 R79762.1 EST HUMAN y189f1O.rl Scares placenta Nb2HP Homo sapiens cDNA done IMAGE:146443 5' 2584 7677 12879 0.5 4.OOE-28 AW195066.1 EST HUMAN xn33c09.xl NCI WAP_Kidll 1 Homo sapiens cDNA done IMAGE:2695504 Ysimilar to SW:GG95 HUMAN Q08379GOILGIN-95.; 3070 8221 13320 3.4 4.OOE-28 BE409100.1 EST-HUMAN 601300703F1 NIH MGC - 21 Homo sapiens cDNA done IMAGE:3635305 5, 1262 6391 0.6 3.OOE-28 AF155382.1 NT Homo sapiens metalloprotease-like, disintegrin-like. cysteine-rich protein 2 epsilon (ADAM22) mRNA, complete cds 83 5289 10416 2.2 2.OOE-28 BE0621167.1 ESTHUMAN RC1-BT0254-220300-0191- c05 BT0254 Homo saplens cDNA 1149 6284 11437 3.4 2.OOE-28 Y1 1107.3 NT Homo sapiens ITGB4 gene for Integrin beta 4 subunit, exons 3-41 2427 7526 12732 0.8 2.OOE-28 A1348634.1 EST-HUMAN qo35b06.xl NCI CGAP Lu5 Homo sapiens cDNA done IMAGE:1910483 3'similar to contains L112 L71 repeti---five element; 1463 6590 11765 0.9 1.0OE-28 D38044.11 NT Human gene for Ah-receptor, exon 7-9 Page 86 of 196 Table 4

2650 7739 12939 1.0 1.0OE-28 AF000995.1 NT Horno sapiens ubiquitous TPR motif, Y isoform (UTY) mRNA, alternative transcript 2, complete cds 1584 6710 11881 0.9 7.OOE-29 AW966447.1 EST HUMAN EST378521 MAGE resequences, MAGI Homo sapiens cDNA 580 5740 10857 2.2 6.OOE-29 A1936748.1 EST-HUMAN wp69b01.xl NCI-CGAP_Bm25 Homo saplens cDNA done IMAGE:2466985 Ysimilar to TR:015475 015475 UNNAMED HERV-H PROTEIN;contains LTR711 LTR7 repetitive element 4928 10035 1.0 5.OOE-29 AL163203.2 NT Homo saplens chromosome 21 segment HS21 C003 3194 8343 1.7 4.OOE-29 A1752367.1 EST HUMAN cnl5c02.xl Normal Human Trabecuiar Bone Cells Homo sapiens cDNA done NHTBC cn15c02 random 4317 9440 14529 1.5 3.OOE-29 AB042297.1 NT Horno sapiens PTS gene for 6- pyruvoyftetrahydroetedn synthase, complete cds 484 5649 10772 1.4 2.OOE-29 AF084869.1 NT Homo saplens envelope protein RIC-6 (env) gene, complete cds 484 5649 10773 1.4 2.0OE-29 AF084869.1 NT Homo saplens envelope protein RiC-6 (env) gene, complete cds 1516 6643 11810 2.2 2.OOE-29 A1963604.1 EST HUMAN wr65d10.xl NCI-CGAP-1. 11:1 Homo sapiens cDNA done IMAGE:2492563 Ysimilar to TR:01 5,546 015546 HERV-E ENVELOPE GLYCOPROTEIN; 1516 6643 11811 2.2 2.OOE-29 A1963604.1 EST HUMAN wr65d10.xl NCI_PGAP_Utl Homo saplens cDNA done IMAGE:2492563 3'sImilar to TR:01 5546 015546 HERWE ENVELOPE GLYCOPROTEIN.

1602 6729 11900 0.5 2.OOE-29 AW962209.1 EST HUMAN EST374282 MAGE resequences, MAGG Homo sapiens cDNA 1602 6729 11901 0.5 2.OOE-29 AW962209.1 EST HUMAN EST374282 MAGE resequences, MAGG Homo saplens cDNA 4182 9308 14387 2.0 2.OOE-29 AL163268.2 NT Horno saplens chromosome 21 segment HS21 C068 1499 6625 1.2 7.OOE-30 SE091 133.1 EST-HUMAN PM4-BT0724-150400-004-di 1 BT0724 Horno, saplens cIDNA 1549' 6676 1.0 6.OOE-30 X51755.1 NT Human lambda4mmunoglobidin constant region comElex (germline) 1736 6859 12037 1.3 6.OOE-30 D25303.1 NT Human mRNA for Integrin alpha subunit, complete cds 3153 8302 13410 2.4 6.OOE-30 BE008026.1 EST HUMAN QV(-BN0147-290400-214- f12 ON0147 Homo sapiens cDNA 3931 9065 14152 31.2 5.OOE-30 A1399992.1 EST-HUMAN t992g03.xl NCLCGAP_CLLI Horno saplens cDNA clone IMAGE:2116276 3'similar to contains Alu repetitive element; 2096 7207 12412 0.6 4.0OE-30 AW937471.1 EST HUMAN C1V3-DT0043-090200-080- c06 DT0043 Homo sapiens cDNA 2096 7207 12413 0.6 4.OOE-30 AW937471.1 EST-HUMAN W3-DT0043-09020"80-c06 DT0043 Horno sapiens cDNA 1134 6270 0.6 3.OOE-30 A1338551.1 EST HUMAN qq93c05.xl Soare!_totaLfetu!_Nb2HFQ_9w Homo sapiens cDNA clone IMAGE: 1938920 3, similar to contains MER29.b2 MER29 repetitive element; 3697 8836 13927 0.9 3.0012-30 AF128893.1 NT Homo saplens telomerase reverse transcriptase (TERT) gene, exons 1-6 659 5815 10943 1,2 2.OOE-30 AW857315.1 EST HUMAN CMO-CT0307-310100-158- h03 CT0307 Homo, saplens cDNA 1068 6208 0.8 2.OOE-30 F08688.1 EST - HUMAN HSC23F051 normalized infant brain cDNA Homo saplens CDNA clone c-23f05 1464 6591 11766 2.1 2.OOE-30 SE175877.1 EST-HUMAN RCS-HT0582-110400-013- HO8 HT0582 Homo sapiens cDNA 2889 8640 13141 6.4 2.OOE-30 AF114156.1 NT Homc, sapiens Y-finked zinc finger protein (ZFY) gene, complete cds 3721 8858 13951 2.1 2.OOE-30 AW206581.1 EST-HUMAN Ul-H-Bil-afo-c-12-D-Ul. sl NCI-CGAP_SuW Homo sapiens cDNA done IMAGE:2722558 3, 4668 9780 14878 1.7 2.OOE-30 BE298945.1 EST-HUMAN 601119860F1 MH MGQ_17 Homo sapiens cDNA done IMAGE:3029438 S' 4668 9780 14879 1.7 2.OOE-30 BE298945.1 EST HUMAN 601119860F1 NIH MGC 17 Homo sapiens cDNA done IMAGE:3029438 5' 284 5471 10601 3.5 1.OOE-30 C18939.1 EST-HUMAN Cl 8939 Human placenta cDNA (rFujiwara) Horno sapiens cONA done GEN-570C01 C 527 5691 10813 0,6 1.OOE-30 AW468897.1 EST_HUMAN W30b04.xl SoareNFL,_GBC - S1 Homo saplens cDNA clone IMAGE:2910991 Ysimilar to contains MERI.t3 MER1 MER1 repetitive element; I- Page 87 of 196 699 5854 10989 1.0 1.OOE-30 AL163203.2. NT Horno sapiens chromosome 21 segment HS21C003 2165 7274 12485 1.2 1.0OE-30 AA664377.1 EST-HUMAN ac77b08.sI Stratagene lung (#937210) Honno sapiens cDNA clone IMAGE:868599 3' 2973 8124 13231 1.0 1.OOE-30 5803091 NT Homo saplens methionine aminopepddase, cIF-2-assodated p67 (MNPEP), mRNA 3015 8161 13268 0.9 1.OOE-30 AA315045.1 EST HUMAN EST186868 HCC cell line (matastasis to liver In mouse) 11 Homo sapiens cDNA Vend 1060 6199 11352 0.6 8.OOE-31 8923389 NT Homc saplens hypothetical protein FLJ20420 (FLJ20420), mRNA 2362 7464 1.9 8.OOE-31 AL163208.2 NT Homo sapiens chromosome 21 segment HS21 C008 694 5B49 0.6 7.0OE-311 AA372637.1 EST HUMAN EST84555 Colon adenocarcinoma IV Homo saplens cDNA Wend 2633 7722 12924 0.6 7.OOE-31 BE326517.1 EST-HUMAN hwO5al 1.xl NCI CGAP Lu24 Homo saplens cIDNA done IMAGE:3182012 X 2633 7722 12925 0.6 7.OOE-31 BE326517.1 EST-HUMAN hwO5al 1.xl NCI CGAP Lu24 Homo sapiens cDNA done IMAGE:3182012 3' 3198 8347 13460 4.5 6.OOE-31 AW881551.1 EST-HUMAN RC4-OT0037-1150200-01 1- 908 OT0037 Homo saplens cIDNA 3198 8347 13461 4.5 6.OOE-31 AW881551.1 EST HUMAN RC4-OT0037-150200-01 1 - g08 OT0037 Homo saplens cDNA 3625 8764 2.8 6.OOE-31 AF223391.1 NT Homo sapiens caldurn channel alphal E subunit (CACNA1 E) gene, exons 7-49, and partial cds, alternatively spliced 3827 8964 14063 1.1 6.OOE-31 AW067805.1 EST-HUMAN cnl9d07.xl Normal Human Trabecular Bone Cells Homo sapiens cDNA done NW13C-cri19d07 random 5379 10505 1.0 5.OOE-31 M60694.11 NT Homo sapiens type 1 DNA topolsornerase gene, exon 8 5379 10506 1.0 5.OOE-31 M60694.1 NT Homo saplens type 1 DNA topolsomerase gene, exon 8 5026 101F7 15200 1.7 5.OOE-31 8924243 NT Homo saplens hypothetical protein SIRP-b2 (SIRP-b2), mRNA 5026 10127 15201 1.7 5.OOE-31 8924243 NT Honno sapiens hypothetical protein SIRP-b2 (SIRP-b2), mRNA 581 5741 1.3 4.OOE-31 AJ271735.1 NT Horno, saplens Xq pseudoautosomal region; segment 112 1594 6720 11889 1,0 4.OOE-31 Q10473 SWISSPROT POILYPEPTIDE NACETYLGALACTOSAMINYLTRANSFERASE (PROTEIN-LIDP ACETYLGALACTOSAMINYLTRANSFERASE) (UDP-GALNAC:POLYPEPTIDE, N ACETYLGALACTOSAMINYLTRANSFERASE) (GAILINAC-TI) 1775 6896 0.9 4.OOE-31 AL163280.2 NT Honno saplens chromosome 21 segment HS21C080 2759 7843 1.4 4.OOE-31 5730038 NT Honno sapiens SET domain and mariner transeosase fusion gene (SETMAR) mRNA 2550 7645 12846 0.5 3.OOE-31 6005871 NT Honno saplens SEC63, endoplasmic retIculurn translocon component (S. cerevisiae) like (SEC63Q, mRNA 3055 8206 1.1 3.OOE-31 4505752 NT Homo saplens phosphoglycerate mutase 1 (brain) (PGAM11 mRNA 4303 9427 14517 1.4 3.OOE-31 A1936829.1 EST HUMAN wp70a02.xl NCI--- WAP_13m25 Horno sapiens cIDNA done IMAGE:2467082 3'sImilar to TR:060794 060794 DJ393P1 2,2; 1875 6993 12179 0.7 2.0011-31 AW838171.1 EST-HUMAN W2-LT0051 -260300- 111403 LT0051 Homo saplens cIDNA 2167 7276 12487 1.3 2.OOE-31 A1393388,1 EST HUMAN tg44g05.xl Soarci_NFL. TGB2.Sl Horno sapiens cDNA done IMAGE:2111672 3, 2292 7396 12606 0.8 2.OOE-31 AL1 19245.1 EST-HUMAN DKFZp761G151_rl 761. (synonym: hamy2) Horno sapiens cDNA clone DKFZp761G1513 5, 2391 7491 12696 1.6 2.ODE-31 AA458824.1 ESTHUMAN aa88fil.sl Stratagene fetal retina 937202 Horno saplens cIDNA clone IMAGE:838413 3' similar to contains THRA2 THR repetitive element; 16 5224 10326 2.8 1.OOE-31 U93163.1 N 1 Homo saplens MAGE-52 (MAGE-B2), MAGE-B3 (MAGE-B3), MAGE-B4 (MAGE-B4), and GE:- 1 (MAGE-Bl) genes, complete cds 16,40 U7-66- 11935 0.7 1.0012-31 095371 SWISSPROT OLFACTORY RECEPTOR 2C1 1640 6766 11936 0.7 1.OOE-31 095371 SWISSPROT OLFACTORY RECEPTOR 2C1 1640 6766 11937 0.7 1.OOE-31 095371 SWISSPROT OLFACTORY RECEPTOR 2C1 Page 88 of 196 Table 4

4535 9654 14741 1.0 11.0OE-31 AL134376.1 EST-HUMAN DKIFZp547151235-rll 547 (synonym: htbrl) Horno sapiens cDNA done DIKIFZp54713235 5' 4535 9654 14742 1.0 11.0OE-31 AL134376.1 ES-r-HUMAN DKFZp547B23_rl 547 (synonym: hfbrl) Homo saplens cDNA clone DIKIFZp54713235 5' 2835 7986 1.0 9.OOE-32 U508711.11 NT Human familial Akhelmer's disease (STM2) gene, complete ods 2032 7145 12347 1.2 8.OOE-32 A1056770.11 EST HUMAN oz15a09.xl Soares_fetaLliveLsplect_INFL$_S1 Homo sapiens cDNA clone IMAGE:1675384 31 4754 9865 14958 1.2 7.OOE-32 P52591 SWISSPROT NUCLEAR ENVELOPE PORE MEMBRANE PROTEIN POM 121 (PORE MEMBRANE PROTEIN OF 121 KD) (P145) 2702 7788 12988 0.9 6.OOE-32 A1478104.1 EST---HUMAN tm34a110.xl NCI-CGAP- Kidll 1 Homo sapiens cIDNA clone IMAGE:2159994 3'sImilar to contains MER29J3 MER29 repetitive element; 1018 6158 11311 10.0 5.OOE-32 AF1 16627.1 NT Homo saplens PRO1 181 mRNA, complete ods 915 6061 0.6 4.OOE-32 AL1163246.2 NT Homo sapiens chromosome 21 segment HS21C046 448 5614 10745 1,2 3.OOE-32 Y17293.11 NT Homo sapiens FILIAgene, partial 4783 9893 14986 0.9 2.OOE-32 BE296613.1 EST HUMAN 601173631 F1 N1H MGC 17 Homo saplens cDNA done WAGE:3529159 5' 3435 8577 5.0 9.OOE-33 SE327112.1 EST HUMAN hw07c05.xl NCLCGAP-LU24 Homo sapiens cDNA done IMAGE:3182216 Ysimilar to TR.088539 088539 WW DOMAIN BINDING PROTEIN 1 l.; 54 5263 10382 0.7 7.0012-33 5031736 NT Homo saelens short-chain alcohol dehydrogenase family member (HEP27) mRNA 54 5263 10383 0.7 7.OOE-33 5031736 NT Homo saelens short-chain alcohol dehydrogenase family member (HEP27) mRNA 2115 7226 12434 1.0 7.OOE-33 A15901 15.1 ESI_HUMAN t012b09.xl NCI CGAF_Ut2 Homo sapiens cDNA done IMAGE:2178809 Ysimilar to contains Offi.JOIFR iepedbve element; 3204 8352 12.9 7.OOE-33 AW971307.1 EST-HUMAN EST383396 MAGE resequencbs, MAGI. Homo sapiens cDNA 3676 8815 0.9 6.OOE-33 AL163285.2 NT Homo sapiens chromosome 21 segment HS21 C085 1856 6974 12156 1.4 5.OOE-33 4507208 NT Homo saplens spermidine synthase (SRM) mRNA 1856 6974 12159 1.4 5.OOE-33 4507208 NT Horno sapiens spermidine synthase (SRM) mRNA 2226 7333 1.3 5.OOE-33 AL163285.2 NT Homo saplens chromosome 21 segment HS21 C085 1112 6249 3.3 4.OOE-33 AL163207.2 NT Homo sapiens chromosome 21 segment HS21 C007 2078 7190 12393 0.6 4.0015-33 4758987 NT Homo sapiens RABI, member RAS oncogene family (RAB1) mRNA 2370 7472 2.7 4.OOE-33 AA626621.1 EST HUMAN ab511bl 1A Stratagene lung carcinoma 937218 Homo sapiens cDNA clone IMAGE:844317 5' similar to contains Alu repetitive element;contains MER2812 MER28. repefitive element 2498 7595 12797 1.4 4.OOE-33 AL163210.2 NT Homo sapiens chromosome 21 segment HS21 C01 0 4382 9504 14589 1,5 4.OOE-33 AW293349.1 EST-HUMAN 01-H-BI2-ahl-c-03-0-Ul. sl NCI-CGAP_Sub4 Homo sapiens cDNA clone IMAGE:2727149 3' 1073 6211 1,5 3.OOE-33 BE350127.11 EST-HUMAN ht09901.xl NCLCGAf_K1d13 Homo sapiens cDNA done IMAGE:3146256 Ysimilar to contains MER2913 MER29 repetitive element; 1074 6211 1.2 3.OOE-33 BE350127.1 EST HUMAN ht09901.xl NCI_CGAP_K1d13 Homo sapiens.cDNA done IMAGE:3146256 Ysimilar to contains MER2913 MER29 repetitive element; 4761 9872 14967 3.1 3.OOE-33 A13035346.1 NT Homo saplens TCL6 gene, exon 12 99 5225 0.8 2.OOE-33 AI 160189.1 EST HUMAN qb67903.xl Soares- fetaLhearLNbHHI9W Homo saplens cDNA done IMAGE:1705204 X similar to contains 0FRA OFR repetitive element; Page 89 of 196 Table 4

4322 9445 4. 3 2.OOE-33 BE159039.1 EST HUMAN MRO-HT0405-160300-202-d08 HT0405 Horno sapiens cDNA 4911 10018 15097 5.1 2.OOE-33 AA626683.1 EST-HUMAN ab51gl 1A Stratagene lung carcinoma 937218 Horno sapiens cDNA clone IMAGE:844388 5' similar to gb:X00734_cW TUBULIN BETA-5 CHAIN (HUMAN); 8 5216 1.4 1.OOE-33 AF003528.1 NT Horno saplens X-linked anhidrolfic ectodermal dysplasia protein gene (EDA), exon 2 and flanking repeat regions 1427 6554 11730 0.7 7.OOE-34 T70845.1 EST HUMAN yd15e05xl Soaresfetal liverspleen WLS Homosaplens cDNAdone IMAGE:108320 5, 463 5628 10757 1.5 6.OOE-34 U10991.1 NT Human G2 protein mRNA, partial cds 463 5628 10758 1.5 6.OOE-34 U10991.1 NT Human G2 protein mRNA, partial cds 1837 6956 0.8 5.OOE-34 7706500 NT Homo sapiens Npw38-binding protein NpwBP (LOC51729), mRNA 4363 W5 1.1 5.OOE-34 AA316404.1 EST-HUMAN EST188123 HCC call line (matastasis to liver In mouse) 11 Homo sapiens c[DNA 5'end similar to similar to SI(D3 4993 10096 15163 4.0 5.OOE-34 U30883.1 NT Human splicing factor SRp55-1 (SRp-55) mRNA, complete cds 1953 7070 12267 0.8 4.OOE-34 A1804667.1 EST-HUMAN tt94c06.xl NCI_WAP_Pr28 Homo saplens cDNA done IMAGE:2249194 3' 2687 7774 12973 1.0 4.OOE-34 8922807 NT Homo sapiens hypothetical protein FLJ10989 (FLA0989), mRNA 1488 6615 11786 3.1 1.OOE-34 P12236 SWISSPROT ADP,ATP CARRIER PROTEIN, LIVER ISOFORM T2 (ADPIATP TRANSLOCASE 3) (ADENINE NUCLEOTIDE TRANSLOCATOR 3) (ANT 3) 3621 8760 13852 1.5 1.OOE-34 AF003528.1 NT Horno sapiens X-linked anhidroidc ectodermal dysplasia protein gene (EDA), exon 2 and flanking repeat regions 4381 9503 4.0 1.OOE-34 BE071414.1 EST-HUMAN RC2-BT0506-240400-016-h08 BT0506 Homo sapiens cDNA 4920 10027 0.9 1.OOE-34 AW845706.1 EST HUMAN MRO-CTO068-280999-002-dl 1 CTO068 Homo saplens cDNA 3594 8733 13828 1.3 9.OOE-35 AW663302.1 EST HUMAN hh77b06.yl NCI_CGAP_GU1 Homo sapiens cDNA done IMAGE:2968787 5' 219 5411 8.3 8.OOE-35 6031190 NT Horno sapie s prohibidn (PHB) mRNA 1391 6518 11686 1.3 6.OOE-35 AA757115.1 EST HUMAN ah53h0IsI Soares tests NHT Homo sapiens cIDNA done 1309397 3, 1925 7042 12231 0.6 6.0012-35 6005975 NT Homo saplens zinc finger protein 208 (ZNF208), mRNA 1681 6805 11986 0.8 5.OOE-35 X63392.1 NT H.sapiens Immunoglobulin kappa light chain variable region L14 4311 9434 14524 2.2 5.OOE-35 AF023268.1 NT Homo saplens dk2 kinase (CLK2), propinl, cotel, glucocerebrosidase (GBA), and metaxin genes, complete cds, metaxin pseudogene and glucocerebrosidase pseudogene; and thrombospondin3 (THI3S3) gene, partial ods 1415 6543 11718 5.4 4.0012-35 BE257907.1 EST-HUMAN 601109719F1 NII- LMGQ_16 Homo sapiens cDNA clone IMAGE:3350405 5' 1776 6897 12084 1.9 4.OOE-35 H91 193.1 EST-HUMAN yu98a07A Soares fetal liver spleen 1NFI-S Homo sapiens cDNA clone IMAGE:241236 S' similar to contains PTR5 repetitive element; 5042 10142 1.3 4.OOE-35 BE409102.1 EST-HUMAN 601300705F1 N1H MGC 21 Homo sapiens cDNA done IMAGE:3635401 5' 1561 6688 11856 3.5 3.OOE-35 BE268182.1 EST---HUMAN 601125260F1 NIH-MGC_8 Homo sapiens cDNA done IMAGE:3345063 5' 2283 7389 0.9 3.OOE-35 AF224492.1 NT Homo sapiens phospholipid scramblase 1 gene, complete cds 103 7881 10434 0.6 2.OOE-35 N88965.1 EST HUMAN K6932F Human fetal heart. Lambda ZAP Express Homo saplens cDNA clone K6932 5' similar to REPETITIVE ELEMENT 1171 6305 11460 1.3 2.OOE-35 T1 1909,1 EST HUMAN A971 F Heart Homo saplens cDNA clone A971 1203 6335 11491 0.7 2.OOE-35 6912459 NT Homo saplens Grb2-associated binder 2 (K1AA0571), mRNA 2171 7280 12493 1.9 2.OOE-35 6912459 NT Homo saplens Grb2-assodated binder 2 (K1AA0571), mRNA 3272 8417 13523 -1.0 2.OOE-35 6912459 NT Homo saplens Girb2-assoclated binder 2 (K1AA0571), mRNA Page 90 of 196 Table 4

3272 8417 13524 1.0 2.OOE-35 6912459 NT Homo sapiens Grb2-associated binder 2 (K1AA0571), mRNA 3511 8652 0.9 2.0OE-35 A13020702.1 NT Homo saplens mRNA for KIAA0895 protein, partial ods 3835 8972 14071 1.1 2.OOE-35 BE247575.1 EST HUMAN TCW2E4328 Pedlatric pre- B cell acute lymphoblasfic leukemia Baylor-HGSC project--TCBA Homo sapiens cDNA done TCBAP4328 3835 8972 14072 1.1 2.OOE-35 BE247575.1 EST-HUMAN TCBAP2E4328 Pedlatric pre-B cell acute lymphoblastic leukemia Baylor-HGSC project=TC13A Horno, saplens cDNA done TCBAP4328 4570 9688 2.6 2.OOE-35 H49239,1 EST HUMAN yq19a12xl Soareafetal liverspleen 1NFLS Hornosaplens cDNAdone IMAGE:2740795' 5250 10360 1.5 1.OOE-35 AA631949.1 EST HUMAN fmfc16Regional genomic DNA specific cDNA library Homo sapiens cDNA clone CR12-1 5250 10361 1.5 1.OOE-35 AA631949.1 EST-HUMAN Well 6 Regional genomic DNA specific cDNA library Homo sapiens cDNA clone CR1 2-1 735 5889 11032 15.0 1.OOE-35 AW389473.1 EST HUMAN IL2-ST0162-131099-006- d12 ST0162 Homo sapiens cDNA 735 5889 11033 15.0 1.0012-35 AW389473.1 EST HUMAN 11-2-ST0162-131099-006- d12 ST0162 Homo sapiens cDNA 891 6039 1.2 1.OOE-35 T87947.1 EST HUMAN yd93a01xl Soares fetal liver spleen INFLS Horno saplens cDNA clone IMAGE:1 15752 5' similar to SP:A44282 A44282 RETROVIRUS-RELATED POL POLYPROTEiN - HUMAN 2495 7591 12794 0.8 1.0OE-35 7705994 NT Homo sapiens hypothetical protein (LOC51233), mRNA 2740 7824 13028 191 1.OOE-35 BE350127.1 EST-HUMAN htOggOl.xl N0 CGAf_K1d13 Homo sapiens cDNA clone IMAGE:3146256 Ysimilar to contains MER2i13 MER29 repetitive element., 2740 7824 'A3029 1.1 1.OOE-35 BE350127.1 EST-HUMAN W09g01.xl NCI_Nd.13 Homo saplens cDNA done IMAGE:3146256 3'sImilar to contains MER29.153. MER29.repedfive element; 3094 8245 13347 5.6 1.0OE-35 R67324.1 EST HUMAN Y132c04.sl Soares placenta N1J2HP Homo saplens cDNA done IMAGE:140934 3' 3094 8245 13348 5.6 1.OOE-35 R67324.1 EST HUMAN y132c04.sl Soares placenta Nb2HP Homo saplens cDNA clone IMAGE:140934 31 3104 8254 13358 1.1 1.OOE-35 6006030 NT Horno saplens transcription elongation factor B (Sill), polypeptide 1-like (TCEB1 L) mRNA 4325 9448 14535 4.7 1.OOE-35 7656905 NT Mds musculus activin receptor Interacting protein 1 (AripI -pending), mRNA 4325 9448 14536 4.7 1.0OE-35 7656905 NT Mus musculus activin receptor interacting protein 1 (Adpl -pending), mRNA 2900 8051 13154 0.9 7.OOE-36 AW857579.1 EST HUMAN CM1-CT0315-091299-063- d07 CTO315 Homo sapiens cDNA 3080 8231 4.0 7.OOE-36 4557498 NT Homo sapiens C-terminal binding protein 2 (CT13P2) mRNA 1959 7076 12273 0.7 6.OOE-36 7706622 NT Horno, sapiens ninjudn 2 (NINJ2), mRNA 2367 7469 2.2 6.OOE-36 AB035346.1 NT Horno sapi ns TCL6 gene, exon 133 5329 10460 2.3 5.OOE-36 AJ271735.1 NT Horno sapiens Xq pseudoautosomal region; segment 112 2722 7806 13010 2.8 5.OOE-36 BE388436.1 EST-HUMAN 601285567F1 N1H MGC 44 Horno sapiens cDNA done IMAGE:3607289 5' 3561 8700 13796 2.0 5.OOE-36 A1.163209.2 NT Horno sapi ns chromosome 21 segment HS21 C009 4678 9790 14890 1.4 5.OOE-36 5729729 NT Homo saplens AP15-like 1 "1 51-1), . mRNA 4678 9790 14891 1.4 5.OOE-36 5729729 NT Homo sapiens AP15-11ke 1 (APf5LI), mRNA 1205 6337 11493 1.4 4.OOE-36 BE0110038.1 EST-HUMAN PM3-BN0176-100400-001- 904 BN0176 Homo, sapiens cDNA 1424 6551 11728 0.6 4.OOE-36 P10266 SWISSPROT RETROVIRUS-RELATED POL POLYPROTEIN [CONTAINS: REVERSE TRANSCRIPTASE ENDONUCLEASE) 1626 6752 11921 0.6 4.ODE-36. BE382574.1 EST-HUMAN 601298574F1 NIH MGQ_19 Homo sapiens cDNA done IMAGE:3628386 5, 2175 7FC4 0.6 4.OOE-36 AW247772.1 ESTHUMAN 2820020.5prime NiLWCJ Homo saplens cDNA done IMAGE:2820020 5' Page 91 of 196 Table 4

2707 7792 12992 0.9 4.OOE-36 A1392661.1 EST HUMAN tg47b011.xl S ares_NFL T G13Q_S1 Homo saplens cIDNA done IMAGE:2111881 3' 2707 7792 12993 0.9 4.OOE-36 A1392661.1 EST HUMAN to47b01.xl Soares NFL T G13Q_S1 Horno saple s cIDNA done IMAGE:2111881 X 3310 8455 13568 3.2 4.OOE-36 BE389299.1 EST HUMAN 601282266F1 N1H MGC44 Homo sapions dDNA done IMAGE:3604168 5, 3310 8455 13569 3.2 4.OOE-36 BE389299.1 EST HUMAN 601282266F1 N1H MGC 44 Homo sapiens cIDNA done IMAGE:3604168 5' 681 5836 10969 0.9 3.OOE-36 AF099810.1 NT Homo sapiens neureAn Ill-alpha gene, partial ods 2252 7358 12565 0.9 3.OOE-36 7662401 NT Homo sapiens KIAA0952 protein (K1AA0952), mRNA 3005 8157 13258 1.8 2.0011-36 BE267054.1 EST HUMAN 601193463F1 N1H MGCJ Horno sapiens cIDNA done IMAGE:3537590 5' 3132 8281 13389 2.7 2.OOE-36 BE259267.1 EST - HUMAN 601106343F1 NIH MGCJ 6 Homo sapiens cDNA done IMAGE:3342706 5' 4877 9984 15066 4.6 2.0012-36 AW880376.1 EST HUMAN QVO-OT0030-240300-174- h04 OT0030 Horno saplens cIDNA 867 6015. 11175 0.7 1.OOE-36 BE409310.1 EST HUMAN 601300938F1 Nib_1VIGQj21 Homo saplens dDNA done IMAGE:3635480 5' 2098 7209 12416 0.9 1.0015-36 BE146523.1 EST HUMAN RCI-HT0217-131199-021- h07 HT0217.Horno sapiens cIDNA 2098 7209 12417 0.9 1.OOE-36 BE146523.1 EST-HUMAN RC1-HT0217-131199-021- h07 HT0217 Homo sapiens cIDNA 2155 7265 12474 1.3 1.OOE-36 AW205546.1 EST-HUMAN Ul-H-Bll-adt-e-09-0-Ul. sl NCI CGAP_Sub3 Horno saplens cDNA clone IMAGE:2718041 3, 5143 10238 15313 1.4 8.OOE-37 A13020684.1 NT Homo sapiens mRNA for KIAA0877 protein, partial cds 1263 6392 0.9 7.OOE-37 AL042800.1 EST HUMAN DOZp434E042g_rl 434 (synonym: htes3) Horno sapiens cDNA clone DKFZp434E0422 5, 2374 7476 12677 0.8 4.OOE-37 AA702794.1 EST HUMAN zi9ObO4.si Soares- fetai_liveLspicen-1 NFI-S-S1 Homo sapiens cDNA clone IMAGE:448015 5160 10255 1.1 4.OOE-37 N62051.1 EST HUMAN. 3' EST52g10 WATM1 Homo sapiens cDNA done 52g10 similar to human STS G04101 1970 7085 12287 1.0 3.OOE-37 AL048956.1 EST HUMAN DOZp4341-2418 rl 434 (synonym: htes3) Horno sapiens dDNA clone DKRp4341-2418 1970 7085 12288 1.0 3.OOE-37 AL048956.1 EST HUMAN DKFZp4341-2418-rl 434 (synonym: htes3) Hor.ho saplens cIDNA done DKRp4341-2418 2465 7563 0.6 3.OOE-37 AW961150.1 EST-HUMAN EST373222 MAGE resequences. MAGF Homo sapiens cIDNA 2936 8087 3.0 3.OOE-37 AW961 150.1 EST-HUMAN EST373222 MAGE resequences, MAGIF Homo saplens cDNA 4072 9199 14285 1.0 3.OOE-37 8923313 NT Homo sapiens hypothetical protein FLJ20337 (FIL.120337), mRNA 1921 7038 12227 0.5 2.OOE-37 AL1 63247.2 NT Horno sapiens chromosome 21 segment HS21C047 3818 8955 14051 5.1 2.OOE-37 4503210 NT Homo saplens cytochrome P450, subfiamily XWIIA (steroid 27-hydroxylase, 1141 6277 11429 0.8 1.OOE-37 AA018293.1 EST-HUMAN carebrotendinous xanthomatosis), polypepfide 1 (CYP27A1 b) mRNA ze40b0S.rl Soares retina N2b4HR Homo sapiens cIDNA clone IMAGE:361425 5' 2041 7154 12360 1.3 1.OOE-37 AL163281.2 NT Homo saplens chromosome 21 segment HS21C081 3878 9014.14109 22.5 1.OOE-37 AF189011.1 NT Homo sapions dbonudease Ill (RN3) mRNA, complete ods 2135 7245 12452 1,47.OOE-38 AW972825.1 EST-HUMAN EST384920 MAGE resequences, MAGI- Horno sapiens cDNA 710 5864 11000 1.2 5.OOE-38 AW971819.1 EST HUMAN EST383908 MAGE resequences, MAGI- Homo sapiens cIDNA 2404 7503 12710 0.7 5.OOE-38 AJ237740.1 NT Homo sapiens RIBIR gene (partial), exon 8 113 5314 10441 2.6 4.OOE-38 Z25466.1 NT B.taurus mitochonddal aspartate aminotransferase mRNA, complete CDS 113 5314 10442 2.6 4.0OE-313 Z25466.1 NT B.taurus mitochonddal aspartate aminotransferase mRNA, complete CDS 1783 6903 1.4 4.OOE-38 AA582476.1 EST.HUMAN nnS4f12.sl NCI CGAP_K1d6 Homo sapiens cDNA done IMAGE:1087727 3' 2053 7165 1.6 3.OOE-38 AF003530.1 NT Homo saplens homeobox protein CDX4 (C1DX4) gene, complete cds and flanking repeat regions Page 92 of 196 Table 4

3.0011-38 7549807 NT Homo sa lens HIRA Interacting protein 4 naJ-111ke. (HIRIP4). mRNA 1 3638 8777 14012 1.1 3.OOE-38 P53538 swisspROT SSU72 PROTEIN 3781 -8918 14013 1.7 3.0012-38 R5-3538 SWISSPROT SSU72 PROTEIN 3781 8 10368 1.7 3.OOE-38 BE279301.1 EST-HUMAN 601157633F1 NIH MGC 21 Horno sapiens cDNA clone IMAGE:3504272 5' 4513 8 - 11652 0.9 2.OOE-38 AL1 63248.2 Nt Homo sapiens chromosome 21 segment HS211C0413 44 1 1.4 2.OOE-38 5902097 NT Homo sapiens SMT3 (suppressor of mif two 3, yeast) homolog 2 (SMT3H2), MRNA 1358 1 0.9 zw30d01.rl Soares ovary tumor NbHOT Homo sapiens cDNA done IMAGE:770785 5'sImBar 8918 to SW.MAII2LRABIT P45701 MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2 8 - 2 6 3 9632 9 2 4 8 6486 6 6 1627 3 11922 0.6 2.OOE-38 AA437353.1 EST HUMAN MANNOSIDASE; 6753 zw30d0I.rl Soares ovary tumor NbHOT Homo saplens cDNA done IMAGE:770785 5'sImilar 6 to SW0A12 RABIT P45701 MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2 7 1627 6753 11923 0.6 2.OOE-38 AA437353.1 EST HUMAN MANNOSID,SE; 2580 675. 12875 0.7 1OE-3' W07111 EST HUMAN za94a04xl Soares_jetal lung NbHL19W Homo sapiens cDNA clone IMAGE:300174 5' 767, 2,OOE-38 W07055.1 zu62b02xl Soares_tasds_NHT Homo sapiens cDNA done IMAGE:742539 5'similar to 7673 1077 6215 12268 0.8 1.OOE-38 AA401570.1 EST HUMAN contains element MER19 repetitive element; 1954 7071 12290 0.9 1.ODE-38 15. NT Homo sapiens guanine nudeodde binding protein-like 1 GNI.1), mRNA 1973 7088 1.0 1.OOE-38 4885288 NT Homo sapiens KIAA0173 gene product (K1AA0173), mRNA 7661969 NT product (K1AA0443), mRNA 7662129 Homo sapiens KIAA0443 gene -M1 2-59 12329 0.8 OE 38 AF270831.1 NT Homo sapiens cyclin K (UUNK) gene, exon 7 016 7 12753 '06 -70-OE-38 A13037863.1 NT Homo sapiens mRNA for KIAA1442 protein, partial ods 2445 1.4 -i-.odE-38 low density llpoproteln receptor-related protein 6 (LIRP6) mRNA, and 4063 Homo sapiens 4223 9347 14428 0.8 1.OOE-38 4505016 NT translated products - 4229 9353 14434 1.3 1.OOE-38 AL1163203.2 NT Homo saplens chromosome 21 segment HS21 C003 4229 9353 14435 1.3 1.0OE-38 ALI 63203.2 NT Homo saRiens chromosome 21 segment HS21 C003 )In FLJ10600 (FLJlobuu), mIRNA 4493 961 14705 1.2 1.0OE-38 8922543 NT ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16k13 (ATP6C) Homo sapiens 48 5258 10374 1.8 8.OOE-39 4502312 NT mRNA 137 -g5-00 11666 0.6 8.OOE-39 4758229 NT Homo sapiens estrogen receptor- binding fra ent-associated gene 9 (EBAG9) mRNA 0.xl NCI CGAP_VJdl 1 Homo sapiens CDNA done IMAGE:2384491 Ysimilar to wh5311 1788 6908 12364 1,1 8.OOE-39 A1823404.1 EST HUMAN TR:P87890 P8i-890 POL PROTEIN; 2047 7160 2.0 7.0012-39 AL163227.2 NT Homo sapiens chromosome 21 segment H821C027 X-linked anhidrolfic ectodermal dysplasta protein gene (EDA), exon 2 and Homo sapiens 991 6134 11289 1,3 5.OOE-39 F003528.1 NT flanking repeat regions Barstead colon HPI-RI37 Homo sapiens cDNA clone IMAGE:2374063 3'simil7r _to at36b04.xl TR:Q15408 Q15408 NEUTRAL PROTEASE LARGE $UBUNIT;contains LTR7.0 LTR7 2957 8108 13214 5.1 5.OOE-39 A1750154.1 EST HUMAN repetitive element; 638 5701 10823 3.6 OE-39 A13015610.1 NT Chlorocebus aethlops mRNA for ribosomal protein S4X, complete cds 21 segment HS21C010 3525 8666 13770 1.0 4MUt:-;j 4 IU.& NT Homo sapiens chromosome 41 5251 10362 3.8 3.OOE-39 AA631949.11 EST_HUMAN Wcl 6 Regional genomic DNA specific cDNA library Homo sapiens cDNA clone CRI 2-1 Page 93 of 196 Table 4

41 5251 10363 3.8 3.OOE-39 AA631949.1 EST-HUMAN fmfcl6 Regional genomic DNA specific cDNA library Homo saplens cDNA clone CR12-1 41 5251 103654 3.8 3.OOE-39 AA631949.1 EST HUMAN fmfcl6 Regional genomic DNA specific cDNA library Homosapiens cDNAcione CR12-1 4902 10009 15089 2.7 3.OOE-39 AA313045.1 EST HUMAN EST183920 Pancreas tumor 1 Homo sapiens cDNA 5' end similar to similar to glucose transporter 879 6027 1.4 2.OOE-39 BE409203.1 EST HUMAN 601301607F1 NIH MGC 21 Homo saplens cDNA done IMAGE:3636289 5' 894 6042 5.9 2.OOE-39 A1525119.1 EST HUMAN promma-7.1)01.r bvtumor Homo saplens cDNA 5' 1015 6155 1.2 2.OOE-39 AF000573.1 NT Homo sapiens homogendsate 1,2- dioxygenase gene, complete cds 1513 6640 3.7 2.OOE-39 AW372318.1 EST-HUMAN PMO-BT0340-211299-003-d02 BT0340 Homo sapiens cDNA 1930 7047 12239 10.0 2.OOE-39 AA720574.1 EST HUMAN nw21g02.sl NCI CGAP GC130 Homo saplens cDNA done IMAGE:1 241138 3'similar to contains THR.t3HR repetitive element; 2587 7680 12881 0.6 2.OOE-39 AL163248.2 NT Horno sapiens chromosome 21 segment HS21 C048 1497 6623 11793 0.6 1.0OE-39 AJ006345.1 NT Homo sapiens WWT1 gene 1497 6623 11794 0.6 11.0OE-39 A.1006345.1 NT Homo sapiens KVLOT1 gene 1514 6641 11807 1.8 1.OOE-39 7657020 NT Homo sapi ns DMp434P211 protein (DKIFW434P21 1), mRNA 2802 7954 13062 1.8 1.OOE-39 A1750362.1 EST HUMAN w02c1O.y2 Normal Human Trabecular Bone Cells Homo sapiens cDNA done NI-ITBC, cri02c10 random 2802 7954 13063 1.8 1.OOE-39 A1750362.1 EST HUMAN w02c1O.y2 Normal Human Trabecular Bone Cells Homo sapiens cDNA clone NI-ITI3C cnO2c10 random.

4561 9679 14771 5.5 1.0OE-391 AW951995.1 EST-HUMAN EST364065 MAGE resequences, MAGB Homo sapiens cDNA 4561 9679 14772 5.5 1.OOE-39 AW951995.1 EST HUMAN EST364065 MAGE resequences, MAGB Homo sapiens cDNA 4604. 9718 14811 8.6 1.OOE-39 7657020 NT Homo saplens DKFZp434P211 protein (DKFZP434P21 1), mRNA 543 5706 10826 0.6 9.OOE-40 5803210 NT Homo saplens UDP-glucose pyrophosphorylase 2 (UGP2), mRNA 1215 6345 11503 3.5 9.OOE-40 4755145 NT Homo saple s AE-binding protein 1 (AE13P1) mRNA 1215 6345 11504 3.5 9.OOE-40 4755145 NT Homo sapiens AE-binding protein 1 (AEBPl) mRNA 1433 6560 11737 1.8 9.OOE-40 4507512 NT Homo sapiens tissue Inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) (TIMP3) mRNA 3892 10297 14118 3.6 9.OOE-40 AB033070.1 NT Horno sapiens mRNA for KIAA1244 protein, partial cds 4250 9375 14455 0.8 9.OOE-40 4507848 NT Homo sapie s ubiquidn spedfic protease 13 (isopepUdase T-3) (USP1 3) mRNA 4398 9375 14455 1.1 9.OOE-40 4507848 NT Homo sapiens ublquidn specific protease 13 (isopepddase T-3) (USP13) mRNA 3004 8156 13257 1.0 8.OOE-40 AA078165.1 EST HUMAN 7H15A04 Chromosome 7 HeLa cDNA Ubrary Homo sapiens cDNA done 7H15A04 3847 8983 2.4 8.OOE-40 BE396541.1 EST-HUMAN 601288958F1 N11-1 MGC 8 Homo saplens cDNA done IMAGE:3619166 5, 2696 7782 12981 1.4 6.OOE-40 AA361275.1 EST-HUMAN EST70527 T-cell lymphoma Homb sapiens ONA V end similar to similar to zinc finger protein family 2696 7782 12982 1.4 6.OOE-40 AA361275.1 EST_HUMAN EST70527 T-cell lymphoma Homo saplens cDNA Vend similar to similar to zinc finger protein family 7655 12858 0.7 5.OOE-40 AL163285.2 NT Homo sapiens chromosome 21 segment HS21C085 6953 12139 1.4 4.OOE-40 A1686005.1 EST HUMAN tt91b01.xl NC!_CGAP_Pr28 Homo sapiens cDNA done IMAGE:2248873 Ysimilar to TR:073505 073505 POL PROTEIN.; Page 94 of 196 Table 4

2061 7173 1.0 4.00E40 AF003528.1 NT Homo sapiens X-linked anhidroidc ectodermal dysplasia protein gene (EDA), exon 2 and flanking repeat regions 4291 9415 14505 7.9 4.00E40 7662117 NT Homo sapiens KIAA0433 protein (K1AA0433), mRNA 1673 6797 11975 0.5 3.00E40 7705948 NT Homo saplons rec (LOC51201), mRNA 2485 7582 12786 0.6 3.00E40 BE386406.1 EST-HUMAN 601273576F1 N1H MGQ_20 Homo sapiens cDNA done IMAGE:3614635 5' 4040 9168 14253 1.0 3.00E40 A1925949.1 EST-HUMAN wh12107.xl NCI CGAP Kidl 1 Horno sapiens cDNA done IMAGE:2380549 3' 322 5505 11929 4.3 2.00E40 A1223036.1 EST HUMAN qg52h08.x Soares tesds NHT Homo sapiens cDNA done IMAGE:1836847 3' 777 5929 11930 0.9 2.OOE-40 AW303868.1 EST_HUMAN xr24c10.xl ISICI_PGAP_W Homo sapiens cDNA done IMAGE:2761098 Ysimilar to 1633 6759 12196 0.7 2.00E40 AW964909.1 EST HUMAN SWIRS5 MOUSE P97461 40S RIBOSOMAL PROTEIN S5.; 1633 6759 0.7 2.00E40 AW964909.1 EST HUMAN EST376877 MAGE rese uences, MAGH Homo saplens cDNA 1892 7009 0.8 2.00E40 4506188 NT EST376877 MAGE resequences, MAGH Homo sapiens cIDNA Homo sapiens proteasome (prosome, macropain) subunit, alpha type, 7 (PSMA7) mRNA, and translated products 1892 7009. 12197 0.8 2.00E40 4506188 NT Horno sapiens proteasome (prosome, macropain) subunit, alpha type, 7 (PSIVIA7) mRNA, and translated products 2026 7139 12339 1.1 2.00E40 A1968562.1 EST-HUMAN wt90al 1.xl NCI-CGAP_WIS Homo sapiens cDNA done IMAGE:2514716 Ysimilar to TR:Q91929 091929 ZINC FINGER PROTEIN---.

2123 7233 12442 0,9 2.00E40 5453592 NT Homo sapiens adenylA cyclaseassodated protein 2 (CAP2) mRNA 2533 7436 12644 0.9 2.00E40 A.1277892.1 NT Homo saplens partial TTN gene for fifin 2658 7747 1.1 2.OOE-40 BE275932.1 EST HUMAN 601121567F1 NIH MGC 20 Homo sapiens cDNA done IMAGE:3345784 5' 3087 8238 13338 -3.6 2.00E40 5453592 NT Homo sapiens adenyly] cyclaseassodated protein 2 (CAP2) mRNA 3913 6759 11929 6.4 2.00E40 AW964909.1 EST-HUMAN EST376877 MAGE resequences, MAGH Horno sapiens cDNA 3913 6759 11930 6.4 2.00E40 AW964909.1 EST HUMAN EST376877 MAGE resequences, MAGH Homo sapiens cIDNA 4807 9917 15010 1,5 2.00E40 AL163280.2 NT Homo sapiens chromosome 21 segment HS21 C080 4807 9917 15011 1.5 2.OOE-40 A1-163280.2 NT Homo sapiens chromosome 21 segment HS21 C080 865 6013 0.6 1.00E40 AA225989.1 EST HUMAN nc09a09.sl NCUGAP Prl Homo sapiens cDNA done IMAGE:1007608 2653 7742 0,7 1.00E40 BE018348.1 EST HUMAN W9a10.y11 NIH-MW_10 Homo sapiens cDNA done IMAGE:3048570 Ssimilar to TR:M1 58 Q9Z1 58 SYNTAXIN 17.; 3258 8405 1.8 1.00E40 4507142 NT Homo sapiens sorting ne)dn 3 (SW3) mRNA 4505 9624 14716 6.3 1.00E40 4508012 NT Homo sapiens zinc finger protein 200 (ZNF200) mRNA, and translated products 4892 9999 15082 0.9 1.0OE-40 7705778 NT Homo sapiens CGI-65 protein (LOC51103), mRNA 811 7900 11117 0.8 7.00E411 A1934364.1 EST HUMAN wp04h04xl NCI_WAP Kidl 1 Homo saplens cDNA done IMAGE:2463895 3, 811 7900 11118 0.8 7.OOE-41 A1934364.1 ESI_HUMAN wp04h04.xl NCI_CGAP_Kidl 1 Homo sapiens cDNA done IMAGE:2463895 3' 279 5466 10596 0.6 6.00E41 A13037163.1 NT Homo sapiens DSCR5b mRNA, complete cds 2064 7176 12383 0.8 6.00E41 7657042 NT Homo sapiens Down syndrome candidate region 1 (IDSCR1), mRNA 1761 6882 12064 1.3 5.00E.41 T62628.1 EST HUMAN yc03e110. 1 Stratagene lung (#937210) Horno saplens cDNA done IMAGE:79626 3' 1957 7074 12271 1.8 5.OOE-41 AW843784.1 EST HUMAN CM4-CN0044-210100-084- e04 CN0044 Homo sapiens cIDNA 4018 9147 1.0 5.00E411 4885636 NT Homo sapiens target of mybl (chicken) homolog (TOM1), mRNA _L85 55541 0.7 4.OOE-41 BE156318.1 EST HUMAN iOVO-HT0367-150200.114-g09 HT0367 Horno sapiens cIDNA Page 95 of 196 Table 4

0w4seo6.si Soares_parathyroldjumor. NbHPA Homo sapiens cDNA done IMAGE: 1649794 3'stmilar to TR:000597 000597 CYTOCHROME C-LIKE POLYPEPTOE,;contains LTR511 1388 6515 11681 3.4 4.OOE-41 A1027117.1 EST HUMAN LTIRS repetitive element; ow45e06.sl Soares_parathyroittumorNbHPA Horno sapiens cDNA done IMAGE: 1649794 3'slmliar to TR:000597 000597 CYTOCHROME C-LIKE POLYPEPTIDE. xontains LTR511 1388 6515 11682 3.4 4.OOE-41 A1027117.1 EST-HUMAN LTR5 repetitive element; 1404 6531 11702 -0.8 4.0012-41 A13008681.1_ NT Horno sapiens gene for activin receptor h" 118, complete ods tm96c04.xl NCI-C_13m25 Homo sapiens cDNA done IMAGE:2165958 Ysimilar to 1618 6744 11912 3,1 4.OOE-41 A1500406.1 EST-HUMAN contains OFR.bl OFR repetitive element; Homo sapiens 959 kb contig between AMLI and CBR1 on chromosome 21 q22; segment 113 2859 8010 13110 3.0 4.OOE-41 AJ229041.1 NT Horno sapiens 959 kb condg between AML1 and CBR1 on chromosome 21 q22; segment 113 2859 8010 13111 3.0 4.OOE-41 AJ229041.1 NT 4052 F79 14262 1.9 4.OOE-41 X92685.1 NT H.saplens DNase i hypersensitive site (HSS-3) enhancer element 932 6079 11236 0.6 3.OOE-41 A8030176.1 NT Homo sapiens PAD-HI g mRNA for pepfidylarginine deiminase type 11, complete cds Horno saplens DNA, DLECI to ORCTL4 gene region. section 112 (DLEC1, ORCTI- 3, 4240 9365 14446 3.1 3.OOE-41 A8026898.1 NT ORCTI-4 genes, complete cds) 5047 10147 0.9 3.0OE-411 A13037748.1 NT Homo sapiens mRNA for KIAA1327 protein, partial ods 1782 6667 11837 2.6 2.OOE-41 U43701.11 NT Human ribosomal protein 1.23a mRNA, complete cds 1915 7032 12220 0.8 2.OOE-41 AA331940.1 EST HUMAN EST35818 Embryo, 8 week 1 Homo saplens cDNA Vend 2172 7281 12494 1.0 2.OOE-41 AJ271366.1 NT Homo sapiens mRNA for putative adaptor protein (GRI310 gene) 2221 7 Y2-8 12542 1.5 2.OOE-41 X89631.1 NT G.godila D for ZNF80 gene homolog 2798 6667 11837 1.9 2.OOE-41 U43701.1 NT Human ribosomat protein L23a mRNA, complete cds 4521 9640 14731 1.1 2.OOE-4i AL163267.2 NT Homo sapiens chromosome 21 segment HS21C067 4521 9640 14732 1.1 2.OOE-41 AL163267.2 NT Horno saplens chromosome - 21 segment HS21 C067 4465 9585 14681 4.6 1.0OE-41 6678468 NT Mus musculus tubulin alpha 6 (Tuba6), mRNA Homo saplens homoobox protein CDX4 (CDX4) gene, complete ods and flanking repeat 455 5621 10748 1.8 8.OOE-42 AF003530.1 NT regions Homo saplens DNA, DLECII to ORCTL4 gene region, section 112 (DI-EC1, ORCTL3, 2062 7174 12381 1.3 8.OOE-42 AB026898.1 NT ORCTL4 genes, complete cds) 636 5795 10918 4.1 7.OOE-42 AF052051.1 NT Homo sapiens glutathione transferase A4 gene, exon 1 636 5795 10919 4.1 7.OOE-42 AF052051.1 NT Homo saplens glutathione transferase A4 gene, exon 1 916 6062 0.6 7,00E42 AL163285.2 NT Horno saplens chromosome 21 segment HS21C085 1812 69-31 12118 1.2 6.OOE-42 AF012872.1 NT Horno saplens phosphaddylinositol 4-kinase 230 (p14K230) mRNA, complete cds 1812 6931 12119 1.2 6.0012-42 AF012872.1 NT Homo sapiens phosphaddylinositol 4-kinase 230 (p14K230) mRNA, complete cds xp29108.xl NCI CGAF_HN10 Homo sapiens cDNA clone IMAGE:2741799 X similar to 2244 7350 1.3 6.OOE-42 AW238656.1 EST-HUMAN contains Ll.tl C, repetitive element; qu24h09.xl NCLWAP_13r112 Homo sapiens cDNA clone IMAGE:1965761 similar to contains 4936 10042 1.0 6.OOE-42 A1284770.1 EST HUMAN Alu repetitive element; 131 5327 1.9 5.OOE-42 AJ271735.1 NT Homo sapiens Xq pseudoautosornal region; segment 112 431 5598 1072 1.2 5.OOE-42 BE217913.1 EST HUMAN 1031el 1.xl NCI CGAP_Lu24 Horno sapiens cDNA done IMAGE:3175052 X eo Page 96 of 196 478 5644 1.0 5.OOE-42 5730038 NT Homo saplens SET domain and mariner transposase fusion gene (SETMAR) mRNA 479 5645 1.3 5.OOE-42 5730038 NT Homo sapiens SET domain and mariner transposase fusion gene (SETMAR) mIRNA 4884 9992 15073 1.1 5.OOE-42 A1541305.1 EST-HUMAN peel.2-4.FO8.r ecnorm Homo saplens cIDNA 5' 736 5890 11034 3.0 4.OOE-42 AFo55oe6,l NT Homo saplens WC class 1 region 736 5890 11035 3.0 4.OOE-42 AF055066.11 NT Homo saplens MI-IC class 1 region 1050 659 11341 0.9 4.OOE-42 AF189011.1 NT Homo sapiens dbonudeas;"11 1 (RN3) mIRNA, complete cds 4100 9226 14311 1.6 4.OOE-42 X594117.11 NT H.sapiens PROS-27 mRNA 4156 9282 14362 4.5 4.0OE-42 4506496 NT Homo sapiens regulatory factor X, 4 (influences HLA class 11 Wression) (R1FX4) mRNA 4480 9600 14694 10.3 4.OOE-42 4508008 NT Homo sapiens zInc finger protein 177 (ZNF177) mRNA 98 5306 1.0 3.OOE-42 AA486105.1 EST HUMAN abl 4el 0.sI Stratagene lung (#9372110) Homo saplens cIDNA. done IMAGE:840810 3' similar to contains THR.1:2 THR repetitive element; 2361 7463 1.4 2.OOE-42 AW898344.1 EST-HUMAN RC3-NNO070-270400-01 1-h10 NNO070 Homo sapiens cIDNA 2375 7477 12678 0.8 2.OOE-42 AW250059.1 EST HUMAN 2819293.3prime N1H MGQ_7 Horno saplens cDNA done IMAGE:2819293 3' 717 5870 11010 1.1 1.OOE-42 X571147.1 NT Human endogenous retrovirus pHE. 1 (ERV9) 1026 6166 11321 1.0 11.0OE-42 AW295809.1 ES-_HUMAN U]-H-Bil-ath-eUi.sl. NCLCGAFSub3 Homo sapiens cDNA done IMAGE:2721871 3' 1085 6223 11374 1.1 11.0OE-42 A.1251818.11 NT Homo saplens partial C9 gene for complement component C9, exon 1 1085 6223 11375 1.1 1.0OE-42 AJ251818.1 NT Homo saplens partial C9 gene for complement component C9, exon 1 1222 7910 11515 4.4 1.OOE-42 AF067166.1 NT Homo saplens NADH-ubiquinone oAdoreductase AGGG subunit precursor homolog mRNA, nuclear gene encoding mitochondrial protein, complete cds 1222 7910 11516 4.4 11.0OE-42 AF067166.1 NT Homo saplens NADH-ubiquinone oxIdoreductase AGGG subunit precursor homolog mRNA, nuclear gene encoding mItochondrial protein, complete cds 1986 7101 12304 0.9 11.0OE-42 AF1 10296.1 NT Homo sapiens PIDNIP1 gene, exon 17 2497 7594 12796 0.7 11.0OE-42 5174458 NT Homo saplens major histocompatibility complex, class It, DM alpha (HLA-DMA) mRNA 2935 8086 13194 8,9 1.0OE-42 4505524 NT Homo saplens origin recognidon complex, subunit 5 (yeast homolog)-like (ORC5L) mRNA, and translated products 3647 8786 13879 2.2 11.0OE-42 7662027 NT Homo sapiens KIAA0255 gene product (K1AA0255), mRNA 3849 8985 14085 1.0 11.0OE-42 AL1 63267.2 NT Homo sapiens chromosome 21 segment HS21C067 4153 9279 14359 1.7 1.OOE-42 AL163280.2 NT Homo sapJens chromosome 21 segment HS21C080 4489 9609 14702 0.9 11.0OE-42 AW813617.1 EST_HUMAN RC3-ST0197-161099-012- a03 ST0197 Homo saplens cIDNA 4640 9754 14848 2.9 11.0OE-42 5803122 NT Homo sapiens proteasome Inhibitor (P131), mRNA 4640 9754 14849 2.9 1.OOE-42 5803122 NT Homo saplens proteasome Inhibitor (P131), mRNA 4669 9781 14880 5.4 1.OOE-42 4506758 NT Homo saplens ryanodine receptor 3 (RYR3) mIRNA 4769 9880 14974 1.2 11.0DE-42 AB03311141 NT Homo saplens mRNA for K1AA11 288 Rrotain, partial ods 5048 10148 15225 1.0 1.0OE-42 4501912 NT Homo sapiens a disintegrin and metalloproteinase domain 23 (ADAM23) mRNA 5048 10148 15226 1.0 11.0OE-42 4501912 NT ns a disintegrin and metalloproteinase domain 23 (ADAM23) mRNA 685 5840 10973 1.5 8.OOE-43 8923276 NT Homo sapiens hypothetical protein FLJ20297 (FU20297), mRNA 685 5840 10974 1.5 8.OOE-43 8923276 NT Homo saplens hypothetical protein FU20297 (FU20297), TRNA 5840 10975 1 5 8.00E43 8923276 NT Horno sapiens hypothetical protein FLJ20297 (FU20297), mRNA 358 8728 13824. 00E43 IAW246442.1 1EST_tiUMAN 2822251.5prime Nit[_MGC 7 Homo sapiens cDNA done IMAGE:2822251 5' Page 97 of 196 Table 4

Page 98 of 196 1320 6449 3.7 6.OOE-43 AA491890.1 EST HUMAN ne72d06.sl NCI-CGAP-Ewl Homo sapiens cDNA done IMAGE:909803 similar to gb105095 60S RIBOSOMAL PROTEIN L30 (HUMAN); 137 5333 0.7 5.OOE-43 AL.163213.2 NT Homo sapiens chromosome 21 segment HS21 C01 3 494 5659 10781 1.0 5.OOE-43 AA382780.1 EST-HUMAN EST96033 Testis 1 Homo sapiens cDNA W end.

957 7865 11260 1.7 4.OOE-43 AF003528.1 NT Homo sapiens X-linked anhidroidc ectodermal dysplasla protein gene (EDA), exon 2 and flanking repeat regions 714 5868 11006 3.3 3.OOE-43 AA083568.1 ESTHUMAN zn09h09.sl Stratagene hNT neuron (#937233) Homo sapiens cIDNA clone I MAGE:546977 X similar to TR:W 136285 G1 136285 UDP-GAL-NACP0LYPEPTIDE N ACETYLGALACTOSAMINYLTRANSFERASE. [1); 1195 6327 1.0 3.OOE-43 AF223391.11 NT Homo saplens calcium channel alphal E subunit (CACNA1 E) gene, exons 7-49. and partial cds, alternatively spliced 1669 6793 11969 0.5 3.OOE-43 X97869.1 NT H.sapiens gene encoding La autoandgen 3524 8665 13769 1.1 3.OOE-43 S69002.1 NT AMO-EVIA=AMLI-EVI-1 fusion protein (rearranged translocation} (human, leukemic cell line SKI-11, mRNA Mutant, 5938 ntl 4193 9319 14404 1.0 3.0012-43 AA548154.1 ESTHUMAN nk55d06.sl NCI CGAP Pr7 Homo saplens cIDNA clone IMAGE:1017419 177 5370 1.5 2.OOE-43 A1190764.1 EST-HUMAN qd61c09.xl Soares_testis_NHT Homo sapiens cIDNA clone IMAGE:1733968 Ysimilar to contains PTIR7.t3 PTR7 PTR7 repetitive element; 1630 6756 11926 1.1 1.0012-43 AF154836.1 NT Homo sapiens Ras-like GTPbinding protein (RAB27A) gene,,exons 1 b and 2 1630 6756 11927 1.1 1.OOE-43 AF154836.1 NT Homo sapiens Ras-like GTP- binding protein (RAB27A) gene, exons I b and 2 1678 6802 11982 1.2 1.00E43 AL163284.2 NT Homo sapiens chromosome 21 segment HS21C084 872 6020 11180 2.0 8.OOE-44 A1222985.1 EST-HUMAN qh23g011.xl Soares NFL T G13p_S1 Homo sapiens cDNA clone IMAGE: 1845552 3' 872 6020 11181 2.0 8.OOE-44 A1222985.1 EST-HUMAN qh23901.xl Soares NFL T G8C S1 Homo sapiens cIDNA done IMAGE:1845552 3' 643 5802 0.9 7.00E44 R06035.11 EST HUMAN ye89e01xl Soares fetal liver spleen 1NIFI.S Homo sapiens eDNA done IMAGE:124920 5' 2187 7296 12510 1.2 7.OOE-44 5031886 NT Homo sapiens LIM domain- containing preferred translocation partner in llpoma (LPP) mRNA 2937 8088 13195 2.2 7.OOE-44 AF048729.1 NT Homo sapiens minisatellite ms32 repeat region 2937 8088 13196 2.2 7.0012-44 AF048729.1 NT Homo sapiens minisatellite ms32 repeat region 3786 8923 14017 2.3 7.00E44 AL163284.2 NT Homo sapiens chromosome 21 segment HS21C084 4148 9274 14353 1.2 7.OOE-44 AF231919.1 NT Homo sapiens chromosome 21 unknown mRNA 4148 9274 14354 1.2 7.00E44 AF231919.1 NT Homo sapiens chromosome 21 unknown mRNA 300 5486 0.9 5.OOE-44 AJ289880.11 NT Homo sapiens KIAA0851 gene (partial), XT3 gene and WFL1 gene 329 5510 0.7 5.OOE-44 AJ289880.1 NT Homo saplens KIAA0851 gene (partial), XT3 gene and LZTFL1 gene 3368 8511 13618 2.9 4.00E44 A1.163303.2 NT Homo sapiens chromosome 21 segment HS21C1 03 1746 6868 1.1 3.OOE-44 6912477 NT Homo sapien karyophedn alpha 6 (impordn alpha 7) (KPNA6), mRNA 3059 8210 13309 5.1 3.OOE-44 AA169851.1 EST HUMAN z18b05.rl Strata ene fetal retina 937202 Homo sapiens cDNA clone IMAGE:609777 5' N 3396 8638 13644 1.5 3.OOE-44 AA683268.1 EST HUMAN ae92b04.sl Stratagene schizo brain S11 Homosapiens cDNACIone IMAGE:1020367 3, 8538 13645 1.5 3.OOE-44 AA683268.1 UST HUMAN ae92b04.sl Stratagene schizo brain S11 Homosapiens cIDNAdone IMAGE:1020367 3, 881 6029 1.4 2.OOE-44 W28189.11 EST ' HUMAN 43c5 Human retina cIDNA randomly primed sublibrary Homo sapiens cIDNA 23396 6173 11325 0.9 2.OOE-44 4826685 NT Homo sapiens DEAD/H (Asp-Glu-Ala- Asp/His) box polypepfide 1 (DDX1) mRNA 103 Table 4

1033 6173 11326 0.9 2.OOE-44 4826685 NT Homo saplens DEAD/H (Asp-Glu-PJaAsl-His) box polypeptide 1 (DDX1) mRNA 1189 6321 11477 1.6 2.OOE-44 5803200 NT Homo sapiens transmembrane trafficking protein (TIVIP21), mRNA 1189 F321 11478 1.6 2.OOE-44 5803200 NT Homo sapiens transmembrane trafficking protein (TMP21), mRNA 1290 U19 11584 1.0 2.OOE-44 AF133586.1 NT Homo sapJens RAB36 (RAB36) mRNA, complete ods 1346 6474 11640 0.5 2.00E44 BE465325.1 EST HUMAN hw14906.xl NCI_WAP_Lu24 Homo saplens cIDNA clone iMAGE:3182938 3'similar to SW:0XYkHUMAN P22059 OXYSTEROL-BINDING PROTEIN.; 2105 7216 12426 0.7 2.OOE-44 AF070651.1 NT Homo saplens Ussue-type bone marrow zinc finger protel 4 mRNA, complete cds 2529 7625 12826 1.1 2.OOE-44 D25303.1 NT Human mRNA for Integrin alpha subunit, complete cds 2567 7660 1.2 2.OOE-44 5901933 NT Homo sapiens adaptor-rotated protein complex 4, sigma 1 subunit (CLAPS4), mRNA 3425 8567 13679 1.4 2.OOE-44 D87675.1 NT Horno sapiens DNA for amytoid precursor protein, complete cds 4466 9588 14684 1.8 2.ODE-44 AW864379.1 EST-HUMAN PM4-SNO01(3-120500-003- a04 SNO016 Homo saplens cDNA 46 5256 10371 1.2 1.OOE-44 7657334 NT Homo sapiens Misshapen/NIK-related kinase (MINK), mRNA 46 5256 10372 1.2 1.0OE-44 7657334 NT Homo saplens Misshap6n/NIK-related kinase (MINK), mRNA 566 5727 10844 0.6 1.00E44 AW853132.1 EST-HUMAN IRC1-CT024"30300-026-h112 CTO249 Romo saRlens cDNA 1179 6312 0.5 1.OOE-44 AW994803.1 EST-HUMAN RC1-BN0039-110300.012-b01 SNO039 Homo saplens cDNA 1555 6682 2.0 1.OOE-44 AL1 63303.2 NT Homo saplens chromosome 21 segment HS21C103 2177 7286 12497 1.3 1.OOE-44 AA434554.1 EST-HUMAN zw53d02xl SoaresjotaLfetus - N152W6Jw Homo saplens cDNA clone IMAGE:773763 5, similar to contains THR.t3 THR repetitive element; 2177 7286 12498 1.3 1.OOE-44 AA434554.1 EST-HUMAN zw53d02xl Soares_totaLfetus_Nb2HF8 - 9w Homo sapiens cDNA clone IMAGE:773763 5' similar to contains THR.t3 THR repetitive element; 2237 7938 12556 1.1 1.0OE-44 AA398099.1 EST HUMAN zt88gl I.rl Soares--- testis_NHT Homo saplens cDNA done IMAGE:729476 5' 2732 7816 130211 1.4 1.00E44 AF196779.1 NT Homo sapiens transcription factor IGHM enhancer 3, JM1 1 protein, JM4 protein, JM5 protein, T54 protein, JM10 protein, A4 differentadon-dependent protein. triple LIM domain protein 6, and synaptophysin genes, complete cds; and L-type calcium channel a> 3664 8803 5.1 1.0OE-44 AA455869.1 EST-HUMAN aaOlcOg.sl Soares_WHIVIPu SI Homo sapiens cDNA done IMAGE:81 1984 3' 5061 10159 15234 0.8 1.OOE-44 AJ130755.1 NT Horno saplens alpha satellite DNA, M1 monomer type 5061 10159 15235 0.8 1.0OE-44 AJ130755.1 NT Homo saplens alpha satellite DNA, M1 monomer type 4476 9596 14691 1.7 9.OOE-45 8922391 NT Homo sapiens hypothedcal protein FLJ 10379. (FLJI 0379). mRNA 4476 9596 14692 1.7 9.OOE-45 8922391 NT Homo sapiens hy2othedcal protein FLJ10379 (FLA0379), mRNA 2477 7575 12777 1.4 8.OOE-45 5174718 NT Homo saplens TRK-fused gene (NOTE: non-standard symbol and name) (TFG) mRNA 5015 10117 15188 7.5 8.OOE-45 5174718 NT Homo saplens TRK-fused gene (NOTE: non-standard symbol and name) (TFG) mRNA 3896 9031 5.3 6.OOE-45 AW157570.1 EST - HUMAN au83h07.xl Schnelder fetal brain 00004 Homo sapiens cDNA clone IMAGE:2782909 3' similar to SCR13A-HUMAN P40429 60S RIBOSOMAL PROTEIN LIM; 874 6022 1.1 5.OOE-45 AL163203.2 NT Homo sapiens chromosome 21 segment HS21 C003 3173 8322 13436 2.0 5.OOE-45 A1523766.1 EST-HUMAN t994f07.xl NCI_CGAP_CLLI Homo sapiens cDNA done IMAGE:2116453 Ysimilar to SW:PAXII-MOUSE P09084 PAIRED BOX PROTEIN PAM.; 1127 6263 11415 3.1 4.OOE-45 X95826.1 NT H.saplens ART4 gene 2246 7352 12559 0.7 4.OOE-45 BE265622.1 EST HUMAN 6011 "MOFI N1H MGS.7 Homo saptens cDNA done IMAGE:3538425 51 1190 6322 0.9 3.OOE-45 AW500307.1 EST HUMAN Ut-HF-BNO-akg-d-02-0-Ut.rl NIH-MGQ_50 Homo sapiens cDNA clone IMAGE:3077019 5' IZ, (1>0 Page 99 of 196 Table 4

3997 8434 1.2 3.OOE-45 T71480.1 EST-HUMAN yd35f07xl Scares fetal liver spleen 1NFL.S Homo sapiens cIDNA clone IMAGE:1102455' 4682 9794 14896 1.1 3.0OE-45 BE297384.1 EST-HUMAN 601178009F1 N1H MGC 17 Homo saplens cDNA done IMAGE:3533091 5' 4682 9794 14897 1.1 3.OOE-45 BE297384.1 EST HUMAN 601178009F1 N1H MGQ_17 Homo sapiens cDNA done IMAGE:3533091 5, 2454 7553 0.8 2.OOE-45 AL-163218.2 NT Homo sapions chromosome 21 segment HS21 C01 8 2996 8148 13248 0.9 2.OOE-45 AJ243213.1 NT Homo saplons partial 5-HT4 receptor gene, exons 2 to 5 3509 8650 13760 0.8 2.OOE-45 BE004686.1 EST HUMAN CM1-BN01 1 1-240300-161- b04 BN01 11 Homo sapiens cDNA 118 5571 0.9 1.OOE-45 BE389855.1 ESTHUMAN 601284360F1 N1H MGC 44 Horno sapiens cDNA done IMAGE:3606183 5, 403 5571 0.8 1.OOE-45 BE389855.1 EST HUMAN 601284360F1 N1H MGC 44 Homo saplens cDNA done IMAGE:3606183 5' 464 5629 10759 0.5 1.OOE-45 4506412 NT Homc, sapiens RAP1A, member of RAS oncogene family (RAP1A), mRNA 1157 6292 11447 0.6 1.OOE-45 7657290 NT Horno, saplens Langerhans cell specific o-type loctin (LANGERIN), mRNA 3065 8216 13316 6.8 1.OOE-45 U32169.1 NT Human pro-a2 chain of collagen type X (COL1 1 A2) gene, complete cds 3266 8413 13519 8.2 1.OOE-45 Y16641.1 NT Rattus norvegicus mRNA for hnRNP protein, partial 3447 8589 13703 1.0 1.OOE-45 8659558 NT Homo saplens chromosome 21 open reading frame 1 (C21orf4), mRNA 4378 9500 14587 4.1 11.0OE-45 BE396633.1 EST HUMAN 601289116F1 MH MGC 8 Homo sdplens cIDNA done IMAGE:3619803 5' 2392 7492 12697 3.2 8.OOE-46 A1433261.1 EST-HUMAN fi32f08.xl NCLCGAP_Gas4 Homo sapiens cDNA done IMAGE:2132199 3, similar to gb:J003114-ma2 TUBULIN BETA-1 CHAIN (HUMAN); 2392 7492 12698 3.2 8.OOE-46 A1433261.1 EST-HUMAN U32f08.xl NCI-CGAP_Gas4 Homo saplens cDNA done IMAGE:2132199 Ysimilar to qb:J003114 ma2 TUBULIN BETA-1 CHAIN (HUMAN); 4478 9598 6.5 7.OOE-46 BE386165.1 EST HUMAN 601277292F1 N1H MGC 20 Homo sapiens cDNA done IMAGE:3618119 5' 4701 9813 1.0 7.00IE-46 BE064386.1 EST HUMAN. RC4-13T0310-110300-01 5410 BT031 0 Homo sapiens cDNA 2726 7810 13015 2.0 6.00IE-46 A1884381.1 EST-HUMAN wm31f08.xl NCI_CGAF_Ut4 Horno sapiens cDNA done IMAGE:2437575 3' similar to contains MER19A2 MER19 repetitive element; 2726 7810 13016 2.0 6.OOE-46 A1884381.1 EST-HUMAN wm31f08xl NCI-PGAP-UW Horno, saplens cDNA done IMAGE:2437575 Ysimilar to contains MER19.t2 MER19 repetitive element; 197 5391 2.2 5.OOE-46 AL1 63210.2 NT Homo sapiens chromosome 21 segment HS21C010 625 5784 0.5 4.OOE-46 AA601143.1 EST-HUMAN no54e09.sI ISICI-CO3AP_SS1 Horno saplens cDNA done IMAGE:1 104520 3'similar to gb:X537411-mal FiBULIN-1, ISOFORM A PRECURSOR (HUMAN); 1676 6800 11978 1.3 4.OOE-46 AW770544.1 EST-HUMAN h186c03.xl NCI CGAP_Lu24 Homo saplens cDNAdone IMAGE:3008836 3'similar to gb:X14008 - mil LYSOZYME C PRECURSOR (HUMAN);contains element MER37 repetitive element; 1676 6800 11979 1.3 4.OOE-46 AW770544.1 EST-HUMAN W86c03.xl NCI-CGAF_Lu24 Homo saplens cDNA clone IMAGE:3008836 Ysimilar to gb:X1400_mal LYSOZYME C PRECURSOR (HUMAN);contains element MER37 repetitive element; 2710 7795 12996 1.3 4,OOE-46 M18048.1 NT Human endogenous retrovirus RWL- H2 4320 9443 14531 1.1 4.OOE-46 A13014522.1 NT Homo sapiens mRNA for KIAA0622 protein, partial cds 4320 9443 14532 1.1 4.0012-46 A13014522.1 NT Horno sapiens mRNA for KIAA0622 protein, partial cds 4294 9418 14508 0.8 3.OOE-46 4506376 NT Homo sapiens mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3), mRNA 4666 9778 14875 1.1 3.OOE-46 Z73660.1 NT H.saplens lg lambda light chain variable region gone (7c.1 1.2) germline; lg-Light-Lambda; VI-ambda Page 100 of 196 Table 4

4666 9778 14876 1.1 3.OOE-46 Z73660.1 NT H.sapiens 19 lambda light chain variable region gene (76.11.2) germline: lg-Light-Lambda; Wambda 819 5969 11126 2.0 2.OOE-46 AA468646.1 EST_HUMAN ne06a09.s11 NCLCGAP._Po3 Homo saplens cIDNA done IMAGE:880408 Ysimilar to 1542 6669 11917 1.3 2.OOE-46 AA678246.1 EST-HUMAN contains THR12 THR repetitive element; 1623 6749 0.9 2.OOE-46 U78027.1. zJ27all I.sl Soares_fetal-liveLspleen_l NKS_S1 Homo sapiens cONA done IMAGE:431996 NT 3' Homo sapiens Bruton's tyrosine kinase (BTK), alpha-D-galactosidase A (GLA), L44-like ribosomal protein (L441---)and FTP3 (FTP3) genes, complete cds 4199 9325 14412 1.0 2.OOE-46 AF016191.1 NT Rattus norvegicus potassium channel (er93) mRNA, complete cds 4899 10006 15087 1.2 2.0OE-46 AA399286.1 EST HUMAN zt59e02xl Soares-tesds- NHT Horno, sapiens cDNA done IMAGE:726650 5' similar to SW:RSP11 MOUSE Q01730RSP-1 PROTEIN.; 1213 6343 11502 1.8 1.00E46 4502694 NT Homo sapiens cell division cycle 10 (homologous to CDC10 of S. corevislae) (CIDC10) mRNA 2236 7343 12555 1.7 1.00E46 AW978516.1 EST-HUMAN EST390625 MAGE resequences, MAGP Homo saplens cIDNA 2351 7453 12660 0.9 1.0012-46 H97330.1 EST-HUMAN EST48b095 WATIVI1 Homo sapiens cIDNA done 48b095 3211 8359 13468 2.8 1.OOE-46 AA631912.1 EST HUMAN np78b02.sl NCI-CGAP_Pr2 Homo sapiens cIDNA done IMAGE: 1132395 similar to gb:X76717 H.sapiens MT-11 mRNA. (HUMAN); 4772 9882 2.6 1.OOE-46 AB023197.1 NT Homo saplens mRNA for KIAA0980 protein, partial ods 749 5901 1.5 9.00E47 AJ271735.1 NT Homo saplens Xq pseudoautosomal region; segment 112 4848 9955 15044 2.6 9.00E47 AW770928.1 ESTHUMAN h193e04.xl NCI_PGAP_Lu24 Homo sapiens cIDNA clone IMAGE:3009534 X similar to TR:075703 075703 HYPOTHETICAL 12.4 KID PROTEIN.; 1766 6887 12071 5.1 8.00E47 Y18536.1 NT Homo sapiens HLA-C gene, exon 5, Individual 19323 1766 6887 12072 5.1 8.OOE-47 Y18536.1 NT Homo sapiens HLA-C gene, exon 5, Individual 19323 2684 7771 12971 0.6 8.00E4 5453955 NT Homo sapiens protein phosphatase 2, regulatory subunit B (B56), epsilon Isoform (PPP2R5E) mRNA 2989 8141 13244 1,7 8.OOE-47 AJ229043.1 NT Homo saplens 959 kb config between AMLI and CBR1 on chromosome 21q22, segment 313 693 5848 10983 2.0 6.OOE-47 7705390 NT Homo sapiens H91620p protein (H91620p), mRNA 2501 7598 12798 1.1 6.OOE-47 AL163246.2 NT Homo sapiens chromosome 21 segment HS21C046 1379 6506 11672 1.2 4.00E47 4557556 NT Homo saplens E1A binding protein p300 (EP300) mRNA 171 7882 0.6 3.OOE-47 BE385662.1 EST-HUMAN 601278193F1 N1H MGQ_20 Homo saplens cDNA done IMAGE:3618934 5' 801 5952 11103 1.8 3.OOE-47 N57483.1 EST-HUMAN yy54b04.sli Soares_muidpie- sderosis_2NbHMSP Homo sapiens cDNA done IMAGE:277327 3' 930 6077 11235 3.0 3.00E47 AL163284.2 NT Homo sapiens chromosome 21 segment HS21C084 1984 7099 12302 0,5 3.OOE-47 AB007899.1 NT Horno saplens KIAA0439 mRNA, partial cds 3235 8383 13489 5.1 3.00E47 AA304095.1 EST HUMAN EST16895 Aorta endothelial cells, TNF alpha-treated Homo sapiens cIDNA 5' end similar to similar to metallopanstimulin 1 3885 9021 14473 5.0 3.OOE-47 U93181.1 NT Homo sapiens nuclear dual- specificity phosphatase (SBF1) mRNA, partial s 4265 9390 1.0 3.00E47 M12959.1 NT Human T-cell recoptor active alpha- chain mRNA from JM cell line, complete ods 142 5338 1046 1.5 2,00E4F 4505318 NT Horno sapiens myosin phosphatase, target subunit 2 (MYPT2), mRNA 952 ja 112 0.7 2.00E47 AL163209.2 NT Homo sapiens chromosome 21 segment HS21C009 6098 Page 101 of 196 1 Table 4

952 6098 11255 0.7 2.OOE-47 A1.163209.2 NT Homo sapiens chromosome 21 segment HS21 C009 1548 6675 1.2 2.OOE-47 A1969279.1 EST-HUMAN wq96b02.xl NCI CGAP GC6 Homo sapiens cDNA clone IMAGE:2479851 3' 1575 6701 11870 1.2 2.OOE-47 7662109 NT Homo saplens KIAA0426 gene product (K1AA0426), mRNA.

1654 6779 11952 1.6 2.OOE-47 AA524514.1 EST HUMAN n943h12.sl NCI_PGAF Co3 Homo sapiens cDNA clone IMAGE:937607 3, 2185 7294 12506 0.8 2.0012-47 AF060568.1 NT Homo saplens promyelocytic leukernia zInc; finger protein (PUF) gene, complete ods 2620 7710 12910 0.6 2.OOE-47 AA077092.11 EST HUMAN 7B07G09 Chromosome 7 Fetal Brain cDNA Library Homo sapiens cDNA clone 7B07G09 4251 9376 14456 1.7 2.OOE-47 4504866 NT Homo saplens ring finger protein (C31-11C4 type) 8 (RNF8), mRNA 4287 9412 14499 1.8 2:0OE-47 AA569592.1 EST-HUMAN nf23g07.sli NCI- GAP PrIl Homo sapiens cDNA done IMAGE:91 652 4287 9412 14500 1.8 2.OOE-47 AA569592.1 EST_HUMAN nf23907.sl NCLCGAP PM Homo saRiens cDNA done IMAGE:914652 4406 9526 14616 2.1 2.OOE-47 5174648 NT Homo sapiens RevIRex activation domain binding protein-related (RAB-R) mRNA 4707 9819 14916 1.1 2.0OE-47 AW9651166.1 ESI_HUMAN EST377239 MAGE resequences, MAGI Homo sapiens cDNA 1383 6510 11674 1.6 1.OOE-47 A1333429.1 EST-HUMAN qp99h03.xl Soares feta!_lung_NbHL19W Horno, sapiens eDNA clone IMAGE:1931189 X 3749 8887 13975 0.8 1.0OE-47 BE280477.1 EST_HUMAN 601155321 F1 N1H MGQ_21 Homo sapiens cDNA done IMAGE:3138893 V 3749 8887 13976 0,6 1.0OE-47 BE280477.1 EST HUMAN 601155321F1 NJH MGC 21 Homo saplens cDNA clone IMAGE:3138893 V 5008 10110 15180 2.6 1.OOE-47 AW813906.1 EST HUMAN RC3-ST0197-130400-017h02 ST0197 Homo sapiens cDNA 1595 6721 11890 0.9 9.00E48 AF223391.1 NT Homo sapiens calcium channel alphal E subunit (CACNA1 E) gene, exons 7-49, and partial cds, alternatively spliced 1230 6360 0.5 8.00E48 4501900 NT Homo sapiens aminoacylase 1 (ACY1), mRNA 1231 6560 1.5 8.00E48 4501900 NT Homo sapiens aminoacylase 1 (ACY1), mRNA 3096 8247 13350 3.6 8.OOE-48 AW768477.1 EST HUMAN hk61b03.xl NCLCGAP_Lyml2 Homo sapiens cDNA clone IMAGE:3001133 3' similar to gb:X64707 BREAST BASIC CONSERVED PROTEIN 1 (HUMAN); 3096 8247 13351 3.6 8.0OE-48 AW768477.1 EST_HUMAN hk611b03.xl NCLPGAP_Lym12 Homo sapiens cDNA clone IMAGE:3001133 3'similar to gb:X64707 BREAST BASIC CONSERVED PROTEIN 1 (HUMAN); 482 5648 1.4 7.00E48 AB033035.1 NT Homo sapiens mRNA for KIAA1209 protein, partial ods 483 5648 4.6 7.OOE-48 A13033035.1 NT Homo saplens mRNA for KIAA1209 protein, partial ods 1482 6609 11782 1.1 7.OOE-48 6912719 NT Homo saplens tousled-like kinase 1 LK1), mRNA 1620 6746 11914 1.3 7.00E48 5730038 NT Horno, saplens SET domain and mariner transposase fusion gene (SETMAR) mRNA 1551 6678 11846 0.8 6.OOE-48 AF163441.1 NT Homo sapiens golgin 67 mRNA, complete cds 3269 10295 13521 1.4 5.OOE-48 4826891 NT Horno sapiens phosphodlesterase 1A, calmodulin-deLendent (PDEIA) mRNA 1498 6624 1.3 4.OOE-48 AA1 57453.1 EST-HUMAN zo55c04.sl Stratagene pancreas (#937208) Homo sapiens cDNA done IMAGE:590790 3' similar to contains Ll.t3 L1 repetitive element; 1933 7050 12242 6.9 3.00E48 4885170 NT Homo sapiens chromosome X open reading frame 6 (CXORF6) mRNA 1933. 7050 12243 6.9 3.00E48 4885170 NT Homo sapiens chromosome X open reading frame 6 (CXORF6) mRNA 3579 8718 13816 0.9 3.OOE-48 AW664531.1 EST-HUMAN h114b12.xl NCLCGAP_GUI Homo sapiens cDNA done IMAGE:2972255 3'similar to SW:DMI3-HUMAN P56555 DOWN SYNDROME CRITICAL REGION PROTEIN B.; 39 5249 10359 1.2 2.00E48 AA631940.1 EST HUMAN IMM7 Regional genomic DNA spedfic cDNA library Homo sapiens cDNA clone CR1 7-26 1752 6874 12054 0.9 2.00E48 AA348396.1 EST-HUMAN EST54841 Hippocampus 11 Homo saplens cDNA Vend 1752 6874 12055 0.9 2.00E48 AA348396.1 EST HUMAN EST54841 HIppocampus 11 Horno sapiens cDNA Vend Page 102 of 196 Tabie 4 TC13AP11 D3842 Pediatric pre-B cell acute lymphoblastic leukernia Baylor- HGSC 4431 9552 14646 1.4 2.OOE-48 BE246065.1 EST HUMAN project=TCBA Homo sapiens cDNA clone TCBAP3842 5259 10376 0.9 1.OOE-48 7706534 NT Homo sapiens cisplatin resistance- associated overexpressed protein (LOC51747), mRNA Homo sapiens amyloid beta (A4) precursor protein (protease nexin-li, Alzheirner disease) 855 6004 11164 2.4 1,OOE-48 4502166 NT (APP), mRNA 1274 6404 11564 1.1 11.0OE-48 5032032 NT Homo sapiens RNA binding motif protein 6 (R8M8) mRNA 1876 6994 12180 16.0 1.OOE-48 AL163302.2 NT Homo sapiens chromosome 21 segment HS21 Cl 02 3443 8585 13699 1.2 1.OOE-48 AL163246.2 NT Homo sapiens chromosome 21 segment HS21 C046 5082 10180 15260 1.1 1.0015-48 M10976.1 NT Human endogenous retroviral DNA (4.1),_wmplete retroviral segment 134 5557 10689 1.5 7.OOE-49 5729990 NT Horno sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 4 (PSMC4) mRNA 134 5557 10690 1.5 7.OOE-49 5729990 NT Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 4 (PSMC4) mRNA 388 5557 10689 0,6 7.OOE-49 5729990 NT Homo saplens proteasome (prosome, macropain) 26S subunit, ATPase, 4 (PSMC4) mRNA 388 5557 10690 0.6 7.OOE-49 5729990 NT Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 4 (PSMC4) mRNA 389 5557 10689 0.7 7.00E49 572 9990 NT Homo, sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 4 (PSIVIC4) mRNA 389 5557 10690 0.7 7.OOE-49 5729990 NT Homo saplens proteasome (prosome, macropain) 26S subunit, ATPase, 4 (PSMC4) mRNA 1202 6334 11490 1.4 7.00E49 AL163284.2 NT Homo saplens chromosome 21 segment HS21C084 yc89b07xl Soares infant brain I NIB Homo sapiens cDNA clone IMAGE:23233 Tsimilar to 2129 7239 12447 0.9 7.OOE-49 T75294.1 EST HUMAN SP:ACUA PENCH P36333 ACETYL-COENZYME A SYNTHETASE; 4550 9669 14759 1.0 7.00E49 060811 SWISSPROT HYPOTHETICAL PROTEIN 0J845024.3 ba55905.xl N1H_MGQ_10 Homo saplens cDNA clone IMAGE:2900504 Ysimilar to qb:X117206 40S RIBOSOMAL PROTEIN S4 (HUMAN); gb:M20632 Mouse LI-Rep21 protein 5384 10511 4.0 6.OOE-49 AW731740,1 EST-HUMAN mRNA from a repetitive element, complete (MOUSE); 4935 10041 15113 1.0 6.OOE-49 AW801668.1 EST - HUMAN IL5-11M0068-080400- 057-00 UM0068 Homo, sapiens cDNA 695 5850 10984 1.2 5.OOE-49 AL163210.2 NT Homo sapiens chromosome 21 segment HS21 C01 0 695 5850 10985 1.2 5.OOE-49 AL163210.2 NT Homo sapiens chromosome 21 segment HS21 C01 0 zp29c07.rl Stratagene neuroepithelium (#937231) Horno, sapiens cIDNA done IMAGE:610860 5'similarto TR:G233226 G233226 RTVL-H PROTEIN. xontains LTR7. t3 1753 6875 12056 0.7 5.OOE-49 AA172121.1 EST-HUMAN LTR7 LTR7 repetitive element; 2721 7805 13009 1.9 5.OOE-49 U17714.1 NT Homo, saplens putative tumor suppressor STI 3 (ST1 3) mRNA, complete cds W08b011.xl NCLCGAP_Ut4 Homo, saplens cDNA clone IMAGE:2675593 Ysimilar to 514 5678 10798 13.0 4.OOE-49 AW189533.1 EST HUMAN WIR:130350.213 CE06703; W 5711 10830 0.9 3,00E49 X68968.1 NT H.sapions mRNA for acetyl-CoA carboxylase ze31c05.rl Soares retina N2b4HR Homo sapiens cDNA done IMAGE:360584 5' similar to 2611 7701 0.7 3,OOE-49 AA016131.1 EST---HUMAN contains 1-14 Ll repetitive element; Ri W- Page 103 of 196 Table 4

Page 104 of 196 4909 10016 15096 2.1 3.0OE-49 U46999.1 NT Human type IV collagen (COL4A6) gene, exon 40 645 5804 0.9 2.OOE-49 BE165980.1 EST HUMAN MR3-HT0487-150200-113-901 HT0487 Homo sapiens cDNA 3185 8334 13446 1.4 2.OOE-49 N26446.1 EST HUMAN yx23d06.M Soares melanocyte 2NbHM Homo sapiens cDNA done IMAGE:262571 5, 3521 8662 13767 0.9 2.OOE-49 AF026564.1 NT Homo sapiens RNA binding protein 11 (R13M11) gene, complete cds 4693 9805 14905 1.1 2.OOE-49 AI 167357.1 EST HUMAN oz88d02.xl SoaresLsenescent-fibroblast!k_NbHSF Homo sapiens cDNA clone IMAGE:1682403 3' similar to gb:M31470 RAS-LIKE PROTEIN TC10 (HUMAN), contains Alu repetitive element;contalns element MER22 repetitive element; 5286 10413 0.6 1.OOE-49 4758135 NT Homo, sapiens DEAD/H (Asp-Glu-AJa- Asp/His) box polypeptide 11 (S.cerevislae CHL1 -like helicase) (DDX1 1) mRNA 5286 10414 0.6 1.0OE-49 4758135 NT Homo sapiens DEAD/H (Asp-Glu-AJa- Asp/His) box polypepfide 11 (S.cerevislae CHL1 -like helicase) (DDX1 1) mRNA 1760 6881 12063 0.9 1.0012-49 BE255216.1 EST HUMAN 601115769F1 N1H. MGQ_16 Homo sapiens cDNA done IMAGE:3356273 5' 4923 10030 1.1 9.OOE-50 AF101475.1 NT Homo, sapiens glydne N- methyttransferase (GNMT) gene, complete eds 163 5358 10483 0.9 8.OOE-50 AL1 63202.2 NT Horno sapiens chromosome 21 segment HS21C002 702 5857 10992 0.6 8.OOE-50 X95097.2 NT Homo saplens mRNA for VIP receptor 2 702 5857 10993 0.6 8.OOE-50 X95097.2 NT Homc sapiens mRNA for VIP receptor 2 1016 6156 1.2 8.OOE-50 AF000573.11 NT Homo saplens homogentisate 1,2- dioxygenase gene, complete cds 1727 6850 12029 0.9 8.0OE-50 4501890 NT Homo sapiens actinin, alpha 1 (ACTNI) mRNA 2324 7427 12637 1.1 8.OOE-50 Y166411.1 NT Rattus norvegicus mRNA for hnRNP protein, partial 2432 7531 12736 1.4 8.OOE-50 7706394 NT Horno sapiens p47 (LOC51674), mRNA 2432 7531 12737 1.4 8.OOE-50 7706394 NT Homo, sapiens p47 (LOC51674), mRNA 2666 7753 12953 0.6 8.OOE-50 4826658 NT Homo, sapiens capeing protein (actin filament) muscle Z-1lne, beta (CAPZI3), mRNA 603 5761 10881 1,0 7.OOE-50 BE089591.1 EST HUMAN QVO-BT0703-280400-21 1 - e08 BT0703 Homo sapiens cIDNA 4002 9133 10.0 5.OOE-50 8922586 NT Homo saplens hypothetical protein FLJ10675 (FL.110675), mRNA 899 6046 1,3 4.OOE-50 AA601143.1 EST HUMAN no54e09.sl NCI_PGA12 SS1 Homo sapiens ciDNA done IMAGE:1 104520 3'similar to gb:X53741 mal FIBULiNA, ISOFORM A PRECURSOR (HUMAN); 1896 7013 0.9 3.OOE-50 M18048.1 NT Human endogenous retrovirus RWL-1-12 3259 8406 13513 1.1 3.OOE-50 AA746142.1 EST-HUMAN obOW06.sl NCI_CGAP_K1d3 Homo saplens,cDNA done IMAGE: 1322627 3' 3692 8831 13924 4.6 3.OOE-50 AW755254.1 EST HUMAN CMYA5 Human cardiac muscJ6 expression library Homo sapiens cIDNA done 4151935 similar to CMYA5 Cardlomyopathy associated gene 5 761 5913 1.7 2.OOE-50 AF055066.1 NT Homo, sapiens MI-IC class 1 region 1063 6201 11355 1.6 2.OOE-50 4557752 NT Homo sapiens midline 1 (Opit7JBBB syndrome) (MIDI) mRNA 1425 6552 11729 6.5 2.OOE-50 AF138303.1 NT Homo sapiens decorin D mRNA, complete cds, alternatively spliced 235 5426 10550 1.0 1.0OE-50 BE007080.1 EST-HUMAN PM3-BN01 37-290300-002- gl 1 BN01 37 Homo sapiens cDNA 235 5426 10551 1.0 1.OOE-50 BE007080.1 EST HUMAN PM3-BN0137-290300-002- 911 BN0137 Homo sapiens cDNA 454 5620 10747 0.7 1,OOE-50 AL163209.2 NT Homo sapiens chromosome 21 segment HS21C009 2314 7417 3,3 1.OOE-50 A.1271735.1 NT Homo sapiens Xq pseudoautwomal region; segment 112 1478 6605 8.2 9.OOE-51 Z12962.1 NT H.saplens mRNA for homologue to yeast dbosomal protein L41 28 5237 10342 0.6 8.OOE-51 AA775999.1 EST---HUMAN ae82g10.sli Stratageneschizo brain S1 1 Homo saplens cDNA clone IMAGE:970722 3' 4467 9587 14683 4.9 8.OOE-51 AA610842.1 EST HUMAN np98e09.sli NCI- CGAP_Lul Homo, sapiens cDNA done IMAGE: 1142440 Ysimilar to qb:X12671 mal HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1 (HUMAN); Table 4

3245 8392 13499 1.4 7.0OE-511 AW889219.1 EST-HUMAN OV4-NT0028.200400-180d05 NT0028 Homo sapiens cIDNA 3317 8462 13574 0.8 7.0OE-511 AW274720.1 EST-HUMAN xn34a03xl NCI - CGAP_Wdll 1 Homo saplens cDNA done IMAGE:2695564 3'similar to TR:WD40 Q9540 ATYPICAL PKC SPECIFIC 13INDING PROTEIN.; 3541 8682 13782 7.4 7.0OE-511 7662109 NT Homo sapiens KIAA0426 gene product (K1AA0426), mRNA 4076 9203 14289 1.3 7.0OE-511 AL-079628.1 DKFZp43413222GLrl 434 (synonym: htes3) Homo sapiens cIDNA clone DKFZp434132229 5' EST_HUMAN 4076 9203 14290 1,3 TOOE-51 AL079628.1 EST HUMAN DKFZp434132229J1 434 (synonym: htes3) Homo saplens cIDNA done DKFZp434B2229 5' 4254 9379 14459 2.4 7.OOE-51 AW295603.1 EST-HUMAN Ul-H-BWO-alp-b-05-0-Ul. sl NCI_WAP_S06 Homo saplens cDNA done IMAGE:2729817 3' 1936 7053 12246 1.9 6.0OE-511 7657266 NT Homo sapiens KIAA0929 protein Msx2 Interacting nuclear target (MINT) homolog (K1AA0929). mRNA 3428 8570 13682 12.9 6.OOE-51 7657266 NT Homo sapiens KIAA0929 protein Msx2 interacting nudear target (MINT) homolog (K1AA0929), mRNA 774 5926 11075 3.7 5.OOE-51 AL163203.2 NT Homo sapiens chromosome 21 segment HS21C003 786 5937 11089 1.5 5.OOE-51 4507500 NT Homo sapiens T-cell lymphorna invasion and metastasis 1 (TIAM1) mRNA 975 7904 11277 1,4 5.OOE-51 AL133204.1 NT Novel human gene mapping to chomosome X 1590 6716 11886 0.8 5.OOE-51 5031980 NT Homo sapiens 26S proteasome- assoclated padl homolog (POH I) mRNA 2548 7644 12843 4.2 5.0OE-511 AJ007558.1 NT Homc, sapiens mRNA for nudeoporin 155 3863 8999 14098 1.1 5.OOE-51 M30938.1 NT Human Ku (p701p80) subunit mRNA, complete cds 3863 8999 14099 1.1 5.OOE-51 M30938.1 NT Human Ku (p701p80) subunit mRNA, complete ods 5004 1015-7 15175 2.3 5.0OE-511 A13037832.1 NT Homo sapiens mRNA for K(AA1411 protein, partial ods 5326 10458 0.9 3.0012-51 A1587348.1 EST_HUMAN tr811c09.xl NCI-CGAF_Panl Horno, saplens cDNA done IMAGE:2224720 X similar to gb:M26326 KERATIN, TYPE 1 CYTOSKELETAL 18 (HUMAN); 613 5771 10891 0.6 3.OOE-51 W79058.1 EST_HUMAN zd76b04.rl Soares_fetaLheart-NbHHI9W Homo sapiens cDNA clone IMAGE:346615 5' 613 5771 10892 0.6 3.OOE-51 W79058,11 EST_HUMAN zd76h04xl Soareectat- heart-NbHHI9W Horno, sapiens cIDNA done IMAGE:346615 5, 1159 6294 11449 1.4 3.OOE-51 A1587348,1 EST-HUMAN tr81c09.xl NCI CUP Panll -- Homo saplens cIDNA done IMAGE:2224720 Ysimilar to gb:M26326 KERATIN,YPE 1 CYTOSKELETAL 18 (HUMAN); 4232 9356 14438 2.1 3.OOE-51- AL159142.1 NT Novel human gene mapping to chomosorne 22 362 5540 10671 0.6 2.OOE-51 4507798 NT Horno, saplens ubiquifin protein ligase E3A (human papilloma virus E6-assodated protein, Angelman syndrome) (UBE3A) mRNA 673 5829 10956 1.1 2.OOE-51 BE391063.1 EST-HUMAN 601285694F1 N1H MG2J44 Homo sapiens cIDNA done IMAGE:3607463 5' 673 5829 10957 1.1 2.0011-51 BE391063.1 EST-HUMAN 601285694F1 NiftMG_44 Horno sapiens cIDNA done IMAGE:3607463 5' 1662 6786 11963 0.8 2.OOE-51 AA233352.1 EST HUMAN zr30a05.rl Stratagene NT2 neuronal precursor 937230 Homo sapiens cIDNA clone IMAGE:664880 5'sImilar to TR:G233226 G233226 RTVL-H PROTEIN.;contains LTR7.Q LTR7 repetitive element; 3672 8811 13905 2.2 2.OOE-51 A149241 5.1 EST HUMAN 927903 xl NCI_PGAP Wdl 1 Homo sapiens cDNA clone IMAGE:2131732 3' 4392 9514 14603 1.0 2.OOE-51 AW137826.1 EST_HUMAN U(-H-Bfl-adj-d-02-0-Ul. sl NCI-CGAP_Sub3 Homo sapiens cDNA done IMAGE:2716851 X U^1 c Page 105 of 196 109 5312 10437 1.5 1.0OE-51 4503528 NT Homo sapiens eukaryotic translation initiation factor 4A, isoform 1 (E1F4A1) mRNA 4309 9432 14521 1.0 1.OOE-51 4759071 NT Homo sapiens small inducible cytokine subfamily A (Cys-Cys), member 15 (SCYA1 5) mRNA 4309 9432 14522 1.0 1.OOE-51 4759071 NT Homo sapiens small Inducible cytokine subfamily A (Cys-Cys), member 15 (SCYA15) mRNA 146 5342 10471 2.5 8.OOE-52 AA720574.1 EST HUMAN nw21g02.sl NCI-CGAP-GCBO Homo saplens cDNA clone IMAGE:1241138 Ysimilar to contains THRA3 THR repetitive element; 1481 6608 11781 1.3 8.OOE-52 X84900.1 NT H.sapiens mRNA for laminin-5, alpha3b chain 1170 6304 0.9 6.OOE-52 BE072409.1 EST HUMAN QV3-BT0537-271299-049-d07 BT0537 Homo sapiens cDNA 1668 6792 11968 0.8 6.OOE-52 AF109907.1 NT Homo sapiens S16.4 gene, partial cds; PS1 and hypothetical protein genes, complete cds; and S171 gene, partial cds 751 5903 11049 0.6 5.OOE-52 AW009208.1 EST-HUMAN ws79a10.xl NCI-CGAP-Co3 Homo sapiens cDNA clone IMAGE:2504154 Ysimilar to TR:043789 043789 OLFACTORY RECEPTOR 751 5903 11050 0.6 5.OOE-52 AW009208.1 EST HUMAN ws79a10.xl NCI - CGAP - Co3 Homo sapiens cDNA done IMAGE:2504154 Ysimilar to TR:043789 O4789 OLFACTORY RECEPTOR; 4340 9463 14553 2.1 5.OOE-52 Z78898.1 NT H.sapiens flow-sorted chromosome 6 Hindll 1 fragment, SC6pAl 81-17 1639 6765 11934 0.9 4.0012-52 AF257318.1 NT Homo sapiens SH3-containing protein SH3GLBI mRNA, complete eds 1748 6870 12048 8.6 4.OOE-52 4758843 NT Homo sapiens nudeoporin 155kD (NUP155) mRNA 2706 7791 20.5 4.OOE-52 AF047677.1 NT Homo sapiens dystrophin (DIVID) gene, deletion breakpoints 1-3 In Intron 5 3850 8986 14086 0.8 4.OOE-52 4507500 NT Homo sapiens T-cell lymphoma Invasion and metastasis 1 (TIAM1) mRNA 577 5737 10853 1.5 3.OOE-52 Z20083.1 EST HUMAN HSAAA13JOK S, Human foetal Adrenals tissue Homo sapiens cDNA 487 5652 10776 0.6 2.OOE-52 AA601246.1 EST-HUMAN nol4g09.sl NCi - CGAP - Phel Homo sapiens cDNA clone IMAGE:1 100704 3'simliar to TR:1E239140 E239140 SPALT PROTEIN; 550 5713 10831 1.4 2.OOE-52 M10976.1 NT Human endogenous retroviral DNA (4-11), complete retroviral segment 550 5713 10832 1.4 2.OOE-52 M10976.1 NT Human endogenous retroviral DNA (M), complete retroviral segment 2450 7549 12758 0.6 2.OOE-52 BE207575.1 EST-HUMAN bb66b07.yl N1H - IVIGCJ Homo saplens cDNA clone IMAGE:3030421 Ssimilar to gb:X16493 M.musculus mRNA for ZpM zinc finger protein (MOUSE); 522 5686 10808 1.4 1.OOE-52 AA634445.1 EST HUMAN zu75h12M Scares tesfisjN1HT Homo saplens cDNA done IMAGE:743879 3, 1349 6477 11643 3.0 1.OOE-52 4504026 NT Homo sapiens glutamate-ammonia ligase (glutamine synthase) (GLUL) mRNA 2489 7586 1.2 1.0OE-52 4502238 NT Homo sapiens aryisulfatase D (ARSD), transcript variant 1, mRNA 3021 8173 13273 1.4 1.OOE-52 S61070.1 NT pol=reverse transcriptase hornolog (retroviral element) [human, endogenous retroviral element RIVIL-Hpl, Genomic, 660 nt] 3723 8860 13952 1.0 9.OOE-53 4506064 NT Horno sapiens protein kinase, cAMP-dependent, regulatory, type 11, beta (PRKAR2B) mRNA 4293 9417 14507 1.0 9.OOE-53 AF001446.1 NT Homo sapiens core binding factor alphal subunit (C13FA1) gene, exon 3 4966 10069 15143 0.9 9.OOE-53 7661713 NT Homo saplens predicted osteoblast protein (GS3786),

* mRNA 4009 9140 14222 2.2 5.OOE-53 4758543 NT Homo sapiens heterogeneous nuclear ribonudeoprotein C (Cl/C2) (HNRPC) mRNA 43 5253 10366 0.7 4.OOE-53 AL163285.2 NT Homo saplens chromosome 21 segment HS21C085 43 5253 10367 0.7 4.OOE-53 AL1 63285.2 NT Homo sapiens chromosome 21 segment HS21C085 9827 14919 1.1 4.OOE-53 7705414 NT Homo sapiens hooki protein (HOOK1), mRNA Page 106 of 196 Table 4

2625 7715 12916 0.9 3.OOE-53 A13026898.1 NT Horno sapiens DNA, DLEC1 to ORCTL4 gene region, section 112 (DLEC1, ORCTL3.

ORCTI-4 genes, complete cds) 3670 8809 13903 1.3 3.OOE-53 AW050836.1 EST HUMAN wz22c07.xl Soarci_DieckgraefeLcolon_NHCD Homo saplens cDNA done I MAGE:2558796 3' 4486 9606 14699 1.2 3.OOE-53 AW803563.1 EST-HUMAN IL2-UM0081-240300.055- DO3 UM0081 Homo sapiens cDNA 4833 9941 15030 0.9 3.OOE-53 BE069344.1 EST HUMAN QV3-BT0381-270100-073- d06 BT0381 Homisapiens cIDNA 450 W1-6 1.5 2.OOE-53 AA366556.1 EST-HUMAN EST77525 Pancreas tumor Ill Homo sapiens cDNA Cend 2279 7385 12592 1.1 2.OOE-53 U78027.1 NT Horno saplens Bruton's tyrosIne kinase (M), alpha-D-galactosidase A (GLA), L44-like dbosornal protein (L441---)and FTP3 (FTP3) genes, complete ods 2490 7587 3.8 2.0OE-53 4502316 NT Horno sapiens ATPase, H+ transporting, lysosomal (vacuolar proton pump) 31 kD; Vacuolar proton-ATPase, subunit E; V-ATPase, subunit E (ATP6E), mRNA 2694 7781 12978 6.9 2.OOE-53 4757915 NT Homo saplens core-bJndJng factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D related (C13FA2T11) mRNA 2694 7781 12979 6.9 2.OOE-53 4757915 NT Homo sapiens core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D related (C13FA2T1) mRNA 3207 8355 13465 1.2 2.OOE-53 AF083822.1 NT Horno saplens dihydropyddine receptor alpha 2 subunit (CACNA2D1) gene, exon 6 3970 9102 14185 2.1 -2.OOE-53 M61873.1 NT Human Krueppel-related DNA- binding protein (M4) gene, partial cds 4390 9512 14600 1.1 2.OOE-53 4506962 NT Homo sapiens SKAPS5 homologue (SKAP-HOM) mIRNA 5091 10189 15267 1.1 2.OOE-53 AL163281.2 NT Homo sapiens chromosome 21 segment HS21C081 5091 10189 15268 1.1 2.0012-53 AL163281.2 NT Homo sapiens chromosome 21 segment HS21 C081 1429 6556 11732 0.9 1.0012-53 AJ271736.1 NT Homo sapi ns Xq pseudoa5tosomal region; segment 212 3364 8507 13615 1.0 1.OOE-53 A13026898.1 NT Horno sapiens DNA, DLECI to ORCTIL4 gene region, secdon 112 (DLEC1, ORCTI-3, ORCTIL4 genes, comElete ods) 5152 10247 15319 0.8 9.OOE-54 4507500 NT Horno saplens T-call lymphoma Invasion and metastasis 1 (TIAM1) mIRNA 5152 10247 15320 0.8 9.OOE-54 4507500 NT Homo sapiens T-cell lymphoma Invasion and metastasis 1 (TIAM1) mRNA 5394 10520 1.1 8.OOE-54 BE386785.1 EST-HUMAN 601272863F1 NIH MGC 20 Homo saplens cDNA clone JMAGE:3614031 S' 1794 6914 12100 1.3 8.OOE-54 4504610 NT Horno sapiens Insulin-like growth factor 2 receptor (IMR) mIRNA 4629 9743 14839 1.3 8.OOE-54 4507848 NT Homo saplens ubiquidn specific protease 13 (isopepddase T-3) (USP13) mRNA 4629 9743 14840 1.3 8.0012-54 4507848 NT Homo sapiens ubiquidn specific protease 13 (Isopeptidase T-3) (USP13) mRNA 5030 9743 14839 1.1 8.OOE-54 4507848 NT Homo saplens ubiquifin specific protease 13 (isopepddase T-3) (USP13) mRNA 5030 9743 14840 1.1 8.OOE-54 4507848 NT Horno sapiens ubiquidn specific protease 13 (isopepddase T-3) (USP13) mRNA 379 5585 10718 1.3 7.OOE-54 AA812537.1 EST HUMAN a179c12.si Soares_tesds- NHT Homo saplens cONA done 1377046 Ysimilar to contains MER30A3 MER30 repetitive element; 1789 6909 12095 0.6 7.0OE-54 Y16WA NT Homo sapiens mRNA for monocyte chernotactic pCotein-2 2158 7267 12477 1.7 7.OOE-54 N27177.1 EST-HUMAN yw68d12,sl Soares_piacenta-8t09weeke_2NbHP8togW Homo sapiens cDNA done IMAGE:257399 3'similar to contains LTR713 LTR7 repetitive element; 22 5231 10334 0.5 6.OOE-54 AB003618.1 NT Horno saplens DNA for MIC13, exon 4. 5 and partial cds 1833 6952 12137 0.9 6.OOE-54 4505052 NT Homo sapiens lymphocyte antigen 75 (LY75) mRNA, and translated products 1833 6952 12138 0.9 6.OOE-54 4505052 NT Horno, saplens lymph antigen 75 (LY75) mRNA, and translated products 3246 8393 - 13500 0.8 6.OOE-54 '8922148 NT Horno sapiens hypothetical protein MRp434M035 (DKFZp434M035), mRNA 392 9057 14144 2.4 6.OOE-54 4502872 NT Homo sapiens chloride channel 6 (CLM6) mRNA Page 107 of 196 Table 4

4774 9884 1.7 6.OOE-54 Y09846.1 NT H.sapiens shc pseudogene, p66 Isoform 4930 9884 1.3 6.OOE-54 Y09846.1 NT H.sapions shp pseudogene, p66 Isoform 2104 7215 12425 0.8 5.OOE-54 P51523 SWISSPROT ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN HPF2) 176 5369 36.0 4.OOE-54 AF110103.1 NT Tupala belanged beta-actin mRNA, partial cds EST177696 Jurkat T-cells VI Horno sapiens cIDNA V end similar to glyceraidehyde-3 940 6087 11244 14.0 4.OOE-54 AA306764.11 EST HUMAN phosphate dehydrogenase 1764 6885 12068 1.2 4.OOE-54 D385211.1 NT Human mRNA for KIAA0077 gene. partial ods 1764 6885 12069 1.2 4.OOE-54 D385211.1 NT Human mRNA for KIAA0077 gene, partial cds wd26dl 1.xl SoaresLNFLJ_GBC-SI Homo saplens eDNA clone IMAGE:2329269 3' similar 3168 8317 1.2 4.OOE-54 A1935086.1 EST HUMAN to TR:002711 002711 PRO-POLDUTPASE POLYPROTEIN; 88 5294 10420 1.7 3.OOE-54 AA313487.1 EST HUMAN EST185371 Colon carcinoma (HCC) cell line omosapienscDNA5'end DI(FZp434E073.1jI 434 (synonym: htes3) Horno saplens cDNA clone DKFZp434E0731 5' 2522 7618 12819 0.9 3.OOE-54 AL1 10383.1 EST-HUMAN 2583 7676 0.9 3.OOE-54 A1908757.1 EST HUMAN IL-BT189-190399-007 BT189 Horno sapiens cDNA 626 5785 10906 2.1 2.00FE-54 5031900 NT Homo sapiens killer cell lectin- like receptor subfamily G, member 1 (KLRG1), mRNA 1342 6470 11637 0.7 2.OOE-54 4507164 NT Homosaple s nuclear antigen Sp1100 (SP100) mRNA nt78a09.sl NCI_CGAP_Pr3 Homo sapiens cDNA done IMAGE1204600 similar to contains 1529 6656 11822 0.6 2.OOE-54 AA655008.1 EST-HUMAN element LI repetitive element; au92g03.yl Schneider fetal brain 00004 Horno saplens cIDNA. done IMAGE:2783764 V 2493 7589 12793 1.3 2.OOE-54 AW163175.1 EST-HUMAN similar to SW:WLI_HUMAN 013616 CULUN HOMOLOG 1 2556 7650 12853 0.7 2.OOE-54 AL163210.2 NT Homo sapiens chromosome 21 segment HS21C010 wy60bl 2.xl Soares_NSF_Ffl_9W_OT_PA-P-sl Homo sapiens cDNA done 1.7 2.OOE-54 AW057524.1 EST HUMAN IMAGE:2552927 31 similar to TR:Q62084 Q62084 PHOSPHOLIPASE C NEIGHBORING; 2865 8016 13119 nj45909.si NCI_PGAP_Prg Homo sapiens cIDNA done IMAGE:995488 similar to gb:X53777 3501 8643 4.1 2.OOE-54 AA532925.11 EST-HUMAN 60S RIBOSOMAL PROTEIN L23 (HUMAN); 4110 9236 2.0 2.0012-54 4502642 NT Homo sap ens chaperonin containing Tcomplex subunit 6 (CCT6) mRNA 4343 9466 1.1 2.OOE-54 AL163201.2 NT Homo sapiens chromosome 21 segment HS21C001 4780 9890 14982 1.5 2.OOE-54 7706446 NT Homo sapiens pepddylarginine delminase type Ill (LOC51702), mRNA 5156 10251 15322 0.8 2.OOE-54 AF083823.1 NT Homo saplens dihydropyddine receptor alpha.2 subunit (CACNA2D1) gene, exon 7 1294 6423 14.6 8.OOE-55 Y07829.2 NT Homo sapiens RFB30 gene for RING finge protein1297 6426 0.8 8.OOE-55 Y07829.2 NT Homo sapiens RFB30 gene for RING finger protein yf26c04.rl Soares fetal liver spleen INKS Horno sapiens cIDNA done IMAGE: 127998 5' 1065 6203 11358 1.2 7.OOE-55 R09346.1 EST-HUMAN similar to SP:C561_13OVIN P10897 CYTOCHROME; zj95b09.sI Soare!p_fetal-liveLspleen-1 NIFI-S_SI1 Homo sapiens cIDNA done IMAGE:462617 1732 6855 12032 1.1 5.OOE-55 AA704971.1 EST HUMAN 3' zj95b09.s11 Soares-feta!_iiver-spleen-1 NFI-S-SI1 Homo sapiens cIDNA done IMAGE:462617 1732 6855 12033 1.1 5.OOE-55 AA704971.1 EST-HUMAN 3' 49 7880 10375 1.4 4.OOE-55 AW957994.1 EST HUMAN EST370064 MAGE resequences, MAGE Homo sapiens cIDNA 58131 Homo sapiens RNA binding motif protein, Y chromosome, family 1, member AI (R13MY1 AI) 10941 12.0 4.OOE-55 4826973 NT mRNA 6550 11725 4.OOE-55 7661713 NT Homo sapiens predicted osteoblast protein (GS3786), mRNA Page 108 of 196 Table 4

1422 6550 11726 0.7 4.OOE-55 7661713 NT Homo saplens predicted osteoblast protein (GS3786), mRNA 1979 7094 12295 0.6 4.OOE-55 4506180 NT Homo sapiens proteasome (prosome, macropain) subuffit, alpha type, 2 (PSMA2) mRNA 1979 7094 12296 0.6 4.OOE-55 4W6180 NT Homo saplens proteasome (prosome, macropain) subunit, alpha type, 2 (PSMA2) mRNA 2039 7152 12356 2.8 4.OOE-55 4503314 NT Homo;a-piens diacylgiycerol kinase, gamma (9OkD) (DGKG) mRNA 2039 7152 12357 2.8 4.OOE-55 4503314 NT Homo sapiens dla2Zigiycerol kinase, gamma (9OkD) (DGKG) mRNA 2262 73U8 12578 1.3 4.OOE-55 4507794 NT Homo saplens ubiquifin-conjugadng enzyme E2 variant 1 (UBE2V1) mRNA 2545 7641 1.0 4.OOE-55 AJ271735.1 NT Homo sapiens Xq pseudoautosomal region; segment 112 3242 8389 13496 1.4 4.00IE-55 A1.163300.2 NT Homo sapiens chromosome 21 segment HS21C100 373 5549 10682 0.8 2.OOE-55 X57147.1 NT Human endogenous retrovirus pHE.1 (ERV9) 1 539 5702 0.9 2.0012-55 M10976.1 NT Human endogenous retroviral DNA 14-1), complete retroviral segment 633 5792 10915 1,1 2.OOE-55 4507296 NT Homo sapiens syntaxin-binding protein 1 (STXBPI) mRNA, and translated products 1813 6932 12120 0.8 2.OOE-55 7019494 NT Homo sapiens putative protein 0mannosyttransferase (POMT2), mRNA 1813 6932 12121 0.8 2.0OE-55 7019494 NT Homo sapiens putative protein 0- mann2Ultransferase (POMT2), mRNA 2928 8079 13188 0.8 2.OOE-55 4507798 NT Homo sapiens ubiquldn protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) (U13E3A) mRNA 3141 8290 13396 2,9 2.0012-55 BE070016.1 EST_HUMAN MR1-13TO405-080300-001- c04 BT0405 Homo sapiens cIDNA 3141 8290 13397 2.9 2.OOE-55 BE070016.1 EST HUMAN MR1 -BT0405-080300.001 - c04 BT0405 Homo saplens cDNA 91 5297 10423 0.5 1.OOE-55 4505060 NT Horno sapiens mannose-6-phosphate re-eptor (cation dependent) (M6PR) mRNA 182 5376 10501 4.1 1.OOE-55 U09823.1 NT Orydolagus cuniculus Now Zealand white elongation factor 1 alpha (Rabefla2) mRNA, complete cds 574 5734 1.4 1.0OE-55 A1905421.1 EST_HUMAN RC-BT091-200199.072 BT091 Homo sapiens cDNA 1132 6268 11420 1.2 1.0OE-55 AB020710.1 NT Horno sapiens mRNA For KIAA0903 protein, partial cds 1907 7024 12212 0.9 1.OOE-55 BE277861.1 EST-HUMAN 601120116F1 NIH_MGC 20 Homo sapiens cDNA clone IMAGE:2967027 5' 1907 7024 12213 0.9 I.OOE-55 BE277861,1 EST HUMAN 601120116F1 NIM_MGQ_20 Homo saplens cDNA done JMAGE:2967027 5' 2277 7383 0.8 1.OOE-55 5803174NT Homo sapiens SMA3 (SMA3), mRNA 2290 7673 12603 1.0 1.OOE-55 AF000990.1 NT Homo saplens tesds-specific Testis Transcript Y 1 (TTY1) mRNA, partial cds 2470 7568 12770 12.0 1.OOE-55 AJ278305.1 NT Homo saplens HI-A-ATIO1 gene for MI-IC class 1 antigen, exons 1-8 2507 7603 12803 1.7 1.0OE-55 A8007866.2 NT Homo saplens mRNA for KIAA0406 protein, partial ods 2507 7603 12804 1.7 1.0OE-55 ABOO7866.2 NT Homo saplens mIRNA for KIAA0406 protein, partial cds 2568 7661 12863 1.4 1.OOE-55 L54057.1 NT Homo sapiens CLP mRNA, partial cds 2670 7757 12957 1.6 1.OOE-55 AW027307.1 EST HUMAN wt73a10.xl Soares_thymus_NHFTh Horno sapiens oDNA done IMAGE:2513082 Ysimilar to WRY471-19C.2 CE20263; 2670 7757 12958 1.6 1.OOE-55 AW027307.1 EST - HUMAN wt73a10.xl Soares_thymus_NHFTh Horno saplens cDNA done IMAGE:2513082 3' similar to WRY47H9C.2 CE20263, 3363 8506 13614 1.2 1.OOE-55 W28189.1 EST HUMAN 43c5 Human retina cIDNA randomly primed sublibrary Homo saplens c[DNA 3907 9042 14129 3.5 1 OOE-55 AL163267.2 NT Homo saplens chromWome 21 segment HS21 C067 4197 9323 14410 1,0 1.OOE-55 AL-163210.2 NT Homo saplens chromosome 21 segment HS21 COI 0 4721 9833 14924 1.0 1.OOE-55 A13037163.1 NT Homo sapiens DSCR5b mRNA, complete cds 9833 14925 1.0 1.OOE-55 AB037163.1 NT Homo sapiens DSCR5b mRNA, complete ods s- (S- Page 109 of 196 Table 4

Page 110 of 196 5081 10179 15259 1.2 1.OOE-55 8923125 NT Homo sapiens hypothetical protein FLJ20126 (FI-J20126), mRNA 2703 7789 12989 1.9 7.OOE-56 H19934.1 EST HUMAN yn62903.rl Soares adult brain N2b51-11355Y Homo sapiens cIDNA clone IMAGE:173044 5' similar to contains THR repetitive element; 4261 9386 14470 1.1 6.OOE-56 R96413.1 EST HUMAN yq37e01.0 Scares fetal liver spleen INFLS Homo sapiens dDNA done iMAGE:197976 5' 1666 6790 11966 0.8 5.OOE-56 AW997712.1 EST HUMAN RC3-BN0053-170200-01 1- h01 BN0053 Homo sapiens cDNA 5234 10337 2.1 4.OOE-56 AF141349.1 NT Homo sapiens beta-tubulin mRNA, complete cds 5234 10338 2.1 4.OOE-56 AF141349.1 NT Homo sapiens beta-tubulin mRNA, complete cds 2676 7763 12963 1.5 4.OOE-56 4507728 NT ns tubutin, beta polypepfide (TUBB) mRNA 2676 7763 12964 1.5 4.OOE-56 4507728 NT Homo sapiens tubulin, beta polypeptide (TUBB) mRNA 2781 5679 10800 1.0 4.OOE-56 AF003528.1 NT Homo sapiens X-linked anhidroldc ectodermal dysplasia protein gene (EDA), exon 2 and flanking repeat regions 3138 8287 13394 1.1 4.OOE-56 AW293688.1 EST-HUMAN U1-1-1-B12-aho-d-07-0- Ul.sl NCI C_Sub4 Homo saplens cIDNA clone IMAGE:2727588 3, 1318 6447 11613 9.9 3.OOE-56 8924029 NT Homo sapiens hypothetical protein PRO1 304 (PRO1 304), mRNA 2103 7214 12424 2.7 3.OOE-56 6912697 NT Homo sapiens oncogene TC21 (TC21), mRNA 3086 8237 13336 1.6 3.OOE-56 AA325826.11 ES1-HUMAN EST28889 Cerebellum 11 Homo sapiens cIDNA. & end 3086 8237 13337 1.6 3.OOE-56 AA325826.11 EST HUMAN EST28889 Cerebellum 11 Homo saplens cIDNA C end 3761 8899 1.4 3.OOE-56 AF055068.1 NT Homo sapiens WC class 1 region.:

4327 9450 14538 4.1 3.OOE-56 AL-163268.2 NT Homo saplens chromosome 21 segment HS21 C068 4470 9590 14686 2.1 3.OOE-56 5902085 NT Horno saplens superkiller viralicidic acdvity 2 (S. cerevisiae homolog)4ike (SKIV21---),mRNA 513 5677 1.0 2.OOE-56 AA199818.1 EST HUMAN zq52a08.sli Stratagene neuroepithellum (#937231) Homo sapiens cIDNA clone IMAGE:645206 3@ 716 7897 11008 1.2 2.OOE-56 BE064386.1 ESTHUMAN RC4-BT0310-110300-015-fl 0 BT031 0 Homo sapiens CDNA 716 7897 11009 1.2 2.OOE-56 BE064386.1 EST HUMAN RC4-BT0310-110300-015-fl 0 BT031 0 Homo saplens cIDNA 2334 7437 12645 1.0 2.OOE-56 4585863 NT Homo saplens phosphodlesterase 6A, cGMP-spedfic, rod, alpha (PDE6A), mRNA 2334 7437 12646 1.0 2.OOE-56 4585863 NT Homo saplens phosphodiesterase 6A, cGMP-spedfic, rod, aleha (PDE6A), mRNA 2959 8110 13216 0.9 2.OOE-56 A13037835.1 NT ns mRNA for KIAA1414 protein, partial cds 964 6109 1.4 1.OOE-56 AF190930.1 NT Macaca faselcularls protein tyrosine phosphatase (PRL-1) mRNA, complete cds 3622 8761 13853 1.8 1.OOE-56 AW589833.1 EST HUMAN h923cl 1.xl NCI CGAP GC6 Homo sapiens cDNA done iMAGE:2946452 3' 3622 8761 13854 1.8 1.0OE-56 AW589833.1 EST HUMAN h923cl 1.xl NCI CGAP GC6 Homo sapiens cIDNA done IMAGE:2946452 3' 4963 10066 15138 1,5 1.0011-56 A1905162.1 EST HUMAN QV-BT077-130199-079 BT077 Homo sapiens cDNA 609 5767 0.7 9.OOE-57 AW880885.1 EST-HUMAN CIVO-OT0033-070300-152-h03 OT0033 Homo saplens cDNA 4109 9235 14318 1.2 9.OOE-57 4758279 NT Homo sapiens EphA4 (EPHA4) mRNA 4109 9235 14319 1.2 9.OOE-57 4758279 NT Homo, sapiens EphA4 (EPHA4) mRNA 13 5221 10322 0.5 8.OOE-57 8923349 NT 1.HOM0 saplens hypothetical protein FLJ20371 (FI-J20371), mRNA 294 5480 10611 1.0 8.OOE-57 AW816405.1 EST-HUMAN QV4-ST0234-181199-037- f05 ST0234 Homo sapiens cDNA 866 6014 11174 0 8.0012-57 AW264599.1 EST HUMAN xrO5d10.xl NCI WAIR Bm53 Homo sapiens cDNA done IMAGE:2759251 Ysimilar to gb:1105875 INTERFER6N-GAMMA RECEPTOR 13ETA CHAIN PRECURSOR (HUMAN); 1774 6895 1208 8.OOE-57 AA496109.1 EST HUMAN zv51 b12.rl Scares testis NHT Homo saplens cDNA done IMAGE:757151 5' Table 4

3335 8479 13592 1.0 8.OOE-57 4758279 NT Homo sapiens EphA4 (EPHA4) mRNA 3335 8479 13593 1.0 8.OOE-57 4758279 NT Homo sapiens EphA4 (EPHA4) MRNA 5107 10203 15282 1.0 8.OOE-57 AA9710011.1 EST HUMAN op67h02.sl Soares NFL, GBC S1 Homo sapiens cDNA done IMAGE:1581939 3' 2592 7684 12885 0.7 7.OOE-57 7657592 NT Homo sapiens srng GDS-ASSOCIATED PROTEIN (SMAP), mRNA 2592 7684 12886 0.7 7.OOE-57 7657592 NT Homo sapiens srng GDS-ASSOCIATED PROTEIN (SMAP), mRNA 3212 8360 13469 0.9 7.OOE-57 7242158 NT Homo saplens NME7 (NME7), mRNA 3212 8360 13470 0.9 7.OOE-57 7242158 NT Homo sapiens NME7 (NME7, mRNA 3233 8381 13488 6.5 7.OOE-57 6005979 NT Homo sapiens Kruppel-like factor 8 (KI-F8), mRNA 3801 8938 14032 2,2 7.0OE-57 AF012872.1 NT Homo sapiens phosphaddylinositol 4-kinse 230 (p14K230) mRNA, complete cds 3801 8938 14033 2.2 7.OOE-57 AF0112872.1 NT Homo saplens phosphaddyllnosbi 4-kinase 230 (04K230) mRNA, complete cds 3694 8833 13925 1,2 4.OOE-57 A13026898.1 NT Homo saplens DNA, DLECI to ORCTL4 gene region, section 112 (OLEC1, ORCTL3, ORCTL4 genes, complete cds) 787 5938 11090 0.8 3.OOE-57 4507796 NT Homo saplens ubiquith protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) (UBE3A) mRNA 1309 6437 3.9 3.OOE-57 AA230279.1 EST-HUMAN nc13107.sl NCLCGAf..PM Homo saplens cDNA clone IMAGE:1008037 similar to SW:RS10-HUMAN P46783 40S RIBOSOMAL PROTEIN S10.; 2342 7444 12651 1.0 3.OOE-57 AA348335.1 EST-HUMAN ESTS4770 Hippocampus 11 Homo sapiens cDNA Vend 3514 8655 13762 1.2 3.OOE-57 AF232708.1 NT Homo sapiens cell-line tsA201a chloride Ion current Inducer protein I(Cin) gene, complete cds 3639 8778 115.9 3.OOE-57 AW853964.1 EST HUMAN RC3-CT0254-110300-027-00 CT0254 Horno saplens cDNA 2699 7785 12985 1.2 2.OOE-57 AA845419.1 EST-HUMAN ak02b02.sl Soare"arathyroic_tumor_NbHPA Homo sapiens cDNA clone IMAGE:1404747 Ysimilar to contains Alu repetitive elementcontains element MER22 repetitive element; 3392 8534 2.9 2.OOE-57 AL-163204.2 NT Homo saplens chromosome 21 segment HS21 C004 3M 8646 13755 0,8 2.OOE-57 R07702.1 EST-HUMAN yeg8h0I.rl Soares fetal liver spleen INFLS Homo saplens cDNA clone IMAGE:125809 5, 3504 8646 13756 0.8_ 2.OOE-57 R07702.1 EST-HUMAN ye98h01.rl Soares fetal liver spleen 1 NFLS Homo sapiens ONA done IMAGE: 125809 51 4409 9529 14618 6.9 2.OOE-57 AL163283.2 NT Homo sapiens chromosome 21 segment HS21 C083 2184 7293 12505 1.1 1.0OE-57 AW503208.1 EST-HUMAN Ul-HF-BNO-akt-07-0-Ul. rl NiM_MC 50 Homo saplens cDNA done IMAGE:3078348 51 638 5797 10921 0.9 8.OOE-58 A1798376.1 EST-HUMAN tr34b07.xl NCI-CGAP-Ov23 Homo saplens cDNA done IMAGE:2220181 Ysimilar to TR:015475 015475 UNNAMED HERV-H PROTEIN; 638 5797 10922 0.9 8.OOE-58 A1798376.1 EST_HUMAN tr34h07.xl NCI-CGAP_0v23 Homo sapiens cDNA done IMAGE:2220181 3'simiJar to TR:015475 015475 UNNAMED HERV-H PROTEIN:

2945 8096 2.8 8.OOE-58 7706132 NT Homo sapiens OWC1 protein (LOC51304), mRNA 3382 8525 13631 4.2 7.OOE-58 BE263616.11 EST HUMAN 601192037F1 NIH MGCJ Horno saplens cDNA done IMAGE:3535977 5, 3382 8525 13632 4.2 7.0OE-513 BE2636116.1 EST_HUMAN 601192037F1 N1H 1GC 7 Homo sapiens cDNA done IMAGE:3535977 5' 2207 7316 12529 0.9 6.OOE-58 BE395061.1 ESTHUMAN 601309465F1 NIHMGC 44 Homo sapiens cDNA done IMAGE:3631000 5' 8022 13124 1.2 6.OOE-58 BE242150.1 EST_HUMAN TCAAP1 E121 9 Pedlatric acute myelogenous leukernia call (FAB M1) Baylor-HGSC project=TCAA Homo sapiens cDNA done TCAAP1219 Page 111 of 196 Table 4

2871 8022 13125 1,2 6.OOE-58 BE242150.1 EST-HUMAN TCAAP1E1219 Pediatric acute myelogenous leukemia cell (FAB M1) Baylor-HGSC project=TCAA Horno sapiens cDNA clone TCAA1P1 219 297 5483 10613 1.0 5.0OE-513 4507334 NT Homo sapiens synapManin 1 (SYNJI), mRNA 1176 6310 11464 1.5 5.OOE-58 AW797948.1 EST---HUMAN CM3-UM0043-240300-127- 607 UM0043 Horno sapiens cDNA 1176 6310 11465 1.5 5.OOE-58 AW797948.1 EST_HUMAN CM3-UM0043-240300-1127- e07 UM0043 Homo sapiens cIDNA 1177 6310 11464 1.0 5.OOE-58 AW797948.1 EST HUMAN CM3-UM0043-240300-127- e07 UM0043 Horno sapiens cIDNA 1177 6310 11465 1.0 5.OOE-58 AW797948.1 E9T'HUMAN CM3-UM0043-240300-127- e07 UM0043 Homo sapiens cDNA 3281 8456 13534 3,6 5.OOE-58 AA988183.1 EST HUMAN or98e07.al NCl-WAP Lu5 Homo sapiens cDNA clone IMAGE:1603908 3' 369 5547 106791 6.1 4.OOE-58 4502302 NT Homo sapiens ATP synthase, H+ transporting, mItochondrial F1 complex, 0 subunit (oligomydn sensitivity conferring protein) (ATP50) mRNA 779 5931 11080 0.5 4.OOE-58 4504634 NT Homo sapiens Interleukin 10 receptor, beta (11-1 ORB), mRNA 1452 6579 11753 1,2 4.OOE-58 4503648 NT Homo sapiens coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) (F9) mRNA 2531 7627 12829 1.0 4.OOE-58 AF265555.1 NT Homo sapiens ublquitin- conjugating BIR-domain enzyme APOLLON mRNA, complete cds 2590 7683 12883 1,0 4.OOE-58 U36251.1 NT Human beta-prime-adapfin (BAM22) gene, exon 3 3283 842g 13536 1.1 4.OOE-58 D16470.1 NT Human mRNA, Xq terminal portion 3680 8819 13912 2.1 4.OOE-58 5031660 NT Homo sapiens EGIF-11ke repeats and discoidin Mike domains 3 (EDIL3), mRNA 332 5513 1.2 3.OOE-58 R17879.1 EST HUMAN yg10e02xl Soares Infant brain 1 NIB Homo saplens cDNA done IMAGE:31693 5' 1367 6495 11661 -6.9 3.OOE-58 4758981 NT Homo saplens peptide YY (PYY) mRNA 925 6072 11230 2.8 2.OOE-58 AF068624.1 NT Homo saiens raminoievuiinate synthase 2 (ALAS2) gene, complete cds 1040 6180 11333 0.5 2.OOE-58 AW881145.1 EST-HUMAN OVO-OT0033-010400-182- a07 OT0033 Homo saplens cDNA 1268 6397 4.1 2.OOE-58 BE208532.1 EST HUMAN baO8b07.yl NIH-MGCJ Homo sapiens cIDNA done IMAGE:2823733 Ssimilar to gb:X69391 60S RIBOSOMAL PROTEIN L6 (HUMAN); gb:X81987 M.musculus mRNA for TAX responsive element binding protein (MOUSE); 705 5860 10995 0.9 1.OOE-58 M65134.1 NT Human complement component C5 mRNA, Yend 1052 6191 11343 1.9 1.OOE-58 6274549 NT Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9 (22k1D, B22) (NDUFB9), mRNA 1305 6434 11599 0.7 1.0OE-58 AW957182.1 EST-HUMAN EST369252 MAGE resequences, MAGI) Homo sapiens cIDNA 1305 6434 11600 0.7 1.0012-58 AW957182.1 EST-HU EST369252 MAGE resequences, MAGI) Homo sapiens cIDNA 1375 6503 11668 1.1 1.0OE-58 AJ238093.1 NT Homo sapiens partial AF-4 gene, exons 2 to 7 and AW repeat elements 1641 6767 11938 2.0 1.OOE-58 BE466132.1 EST HUMAN hylOfQB.xl NC1-WAP GC6 Homo sapiens cIDNA done IMAGE:3196935 3 2771 7855 13059 1.0 1.OOE-58 4759169 NT Homo sapiens sterol regulatory element binding transcription factor 2 (SREI3F2) mRNA 3493 8634 13747 1.0 1.OOE-58 4758081 NT Horno sapiens chondroltin sulfate proteoglycan 2 (versican) (CSPG2) mRNA 3493 8634 13748 1.0 1.0OE-58 4758081 NT Homo sapiens chondrolfin sulfate proteoglycan 2 (versican) (CSPG2) mRNA 3659 8798 13892 0.8 1.OOE-58 4507628 NT Homo sapiens transition protein 1 (during histone to protamine replacement) (TNP1) mRNA 4627 9741 14838 0.9 1.OOE-58 M95963.1 NT Human prohonnone converting enzyme (NEC2) gene, exon 4 4895 1000 15085 4.9 1.0OE-58 A1141063.1 EST-HUMAN oz43h01.xl Soares NhHMPu S1 Horno sapiens cDNA done IMAGE:1678129 3' 2182 72911 12503 9.9 8.OOE-59 4507378 NT Homo sapiens TATA box binding protein (TBP) mRNA 3088 8239 13339,2 5.OOE-59 Ai807484.1 EST HUMAN wf48cl 1.xl SoareLNFL T GBC 81 Homo sapiens cIDNA done IMAGE:2358836 3' Page 112 of 196 Table 4

3338 2 3.9 5.0OE-591 AL159142.1 NT Novel human gene mapping to chomosome 22 4559 9677 14769 5.9 5.OOE-59 X83497.1 NT H.sapiens DNA for ZW80-1inked ERV9 long terminal repeat 776 5928 11078 0.8 4.OOE-59 D80006.1 NT Human mRNA for KIAA0184 gene, partial ods 4685 9797 14900 1.2 4.OOE-59 4506758 NT Homo saplens ryanodine receptor 3 (RYR3) mRNA 4685 9797 14901 1.2 4.0012-59 4506758 NT Homo sapiens ryanodine receptor 3 (RYR3) mRNA 9 5217 2.0 3.OOE-59 AW965524.1 ESTHUMAN EST377582 MAGE resequences, MAGI Homo saplens cDNA 221 5413 10534 1.4 3.OOE-59 7662247 NT Homo saplens KIAA0680 gene product (K1AA0680), mRNA 1682 6806 11987 3.6 3.OOE-59 4505860 NT Homo sapiens plasminogen activator, fissue (PLATa) mRNA 1682 6806 11988 3.6 3.OOE-59 4505860 NT Homo sapiens plasminogen activator, tissue (PLATa) mRNA 2082 7194 12398 2.8 3.OOE-59 AF249745.1 NT Homo saplens chromosome 2q22 RhoGEF mRNA, complete cds 2082 7194 12399 2,8 3.OOE-59 AF249745.1 NT Homo sapiens; chromosome 2q22 RhoGEF mRNA, complete ods 3090 8241 13343 3.7 3.OOE-59 4502014 NT Homo sapiens A kinase (PRKA) anchor protein 1 (AKAPI), mRNA 3090 8241 13344 3.7 3.OOE-59 4502014 NT Homo sapiens A kinase (PRKA) anchor protein 1 (AKAP1), mRNA 3753 8891 13981 1.2 3.OOE-59 4508044 NT Homo sapiens zona pellucida glycoprotein 2 (sperm receptor) (ZP2) mRNA 4683 9795 14898 1,1 3.OOE-59 4759329 NT Horno sapiens Testis-specific XK- related protein on Y (XKRY) mRNA 4734 9845 14938 1.9 3.OOE-59 7427522 NT Homo sapiens protein tyrosine phosphatase, receptor type, T (PTPRT), mRNA 157 5353 1,2 1.OOE-59 BE296411.1 ES'-HUMAN 601176757F1 N11-1-MGCJ7 Homo sapiens cDNA clone IMAGE:3531927 5, 2575 7668 0.9 1.OOE-59 AA748.1 EST-HUMAN oa56bl 1.s11 NCI_PGAP_GC131 Homo sapiens cDNA clone IMAGE: 1309029 Ysimilar to TR:Q13537 013537 MER37 TRANSPOSABLE ELEMENT, COMPLETE CONSENSUS SEQUENCE.; 1455 6582 11756 1.0 8.OOE-60 4759159 NT Homo sapiens small nuclear dbonudeoprotein D3 polypeptIde (1 BW) (SNRPD3) mRNA 2125 7235 12443: 1.0 8.OOE-60 5174656 NT Homo sapiens differentiation- related gene 1 (nickel-specAfic Induction protein) (RTP) mRNA 2125 7235 12444 1.0 8.OOE-60 5174656 NT Homo sapiens differendadonrelated gene 1 (nickel-specific Induction protein) (RTP) mRNA 737 5891 11036 2.3 7.OOE-60 AF055066.1 NT Homo sapiens MI-IC. class 1 region 738 5891 11036 11.0 7.OOE-60 AF055066.1 NT Homo sapiens MHC class 1 region 798 5949 11099 1,2 7.OOE-60 4504634 NT Homo saplens intedeukin 10 receptor, beta (ILIORB), mRNA 2081 7193 12397 0.6 7.OOE-60 AF077188.1 NT Homo saplens cullin 4A (CUL4A) mRNA, complete ods 4088 9214 14297 2.6 7.OOE-60 4505488 NT Homo saplens omithine decarboxylase 1 (QDCI) mRNA 78 5284 10410 0.7 5.OOE-60 A1807917.1 EST-HUMAN W52c07.xl Soare_NFkT_GB(_SI Homo saeiens cDNA done IMAGE:2359212 3' 78 5284 10411 0.7 5.OOE-60 Af807917.1 EST HUMAN W52c07.xl Soares_NFL T GBC S1 Homo sapiens cDNA done IMAGE:2359212 3' 2188 7297 12511 0.9 4.ODE-60 AW503208.1 EST HUMAN Ul-HF-BNO-akt-9-07-0-Ul. rl N11-1 MCC 50 Homo saplens cDNA clone IMAGE:3078348 5' 2188 7297 12512 0.9 4.OOE-60 AW503208.1 EST_HUMAN Ul-HF-BNO-akt-g-07-0-Ul. rl NIH MGC 50 Homo sapiens cDNA cJone IMAGE:3078348 5' 2942 8093 1.1 4.OOE-60 AA299037.1 ESI-HUMAN EST1 1498 Uterus Homo saplens cDNA Vend similar to similar to retroArus-related pol 1826 6945 0.8 3.OOE-60 6031190 NT Homo sapiens prohibifin (PHB) mRNA 4354 9476 14567 2.1 3.OOE-60 AJ271735.1 NT Homo sapiens Xq pseudoautosomal region; segment 112 1405 6532 11703 1.0 2.OOE-60 Z1 1694.1 NT H.sapiens 41kDa protein kinase related to rat ERK2 1691 681R 11994 1.3 2.OOE-60 M24603.1 NT Human bcr protein mRNA, S' end 3839 8975 14075 0.8 2.OOE-60 AF231919.1 NT Homo sapiens chromosome 21 unknown mRNA 5675 10796 0.5 1.OOE-60 BE178586.1 ES7_HUMAN - PM3-HT0605-270200-001-e06 HT0605 Homo saplens cDNA p Page 113 of 196 Table 4

2739 7823 13027 0.7 11.0OE-60 L41825.1 NT Homo saplens CYP17 gene, Cend 4874 9981 15065 1.1 1.OOE-60 AL1 63285.2 NT Homo sapiens chromosome 21 segment HS21C085 2635 7724 12927 1.4 8.OOE-61 AW006478.1 EST-HUMAN M05b10.xl NCI_WAR_CO Homo sapiens cIDNA clone IMAGE:2506555 3' 2635 7724 12928 1.4 8.OOE-61 AW006478.1 EST-HUMAN wt05b10.xl NCI_PGAP Co3 Homo sapiens cDNA clone IMAGE:2506555 3' 2921 8072 1.7 8.OOE-61 X57147.1 NT Human endogenous retrovirus pHE.1 (ERV9) 122 5320 10450 0.9 7.OOE-61 7706670 NT Homo sapiens PXR2b protein (PXR2b), mIRNA 122 5320 10451 0.9 7.OOE-61 7706670 NT Homo saplens PXR2b protein (PXR2b), mRNA 123 5320 10450 0.9 7.OOE-61 7706670 NT Homo saplens PX112b protein (PXR2b), mRNA 123 5320.10451 0.9 7.OOE-61 7706670 NT Homo sapiens PXR2b protein (PXR2b). mRNA 265 5452 10577 0.7 6.0012-61 BE40931 0.1 EST - HUMAN 601300938F1 NIH MGC_21 Homo sapiens cDNA clone IMAGE:3635480 5' 794 5945 11096 0.6 6.OOE-61 BE409310.1 EST HUMAN 601300938F1 NIH MGC 21 Homo sapiens cDNA done IMAGE:3635480 5' 1299 6428 11592 3.5 6.OOE-61 AF1 19860.1 NT Homo sapiens PR02014 mRNA, complete ods 1612 6738 11908 1.0 6.OOE-61 BE257400.1 EST HUMAN 601109238F1 NIH MGC 16 Homo sapiens cDNA clone IMAGE:3350145 5, 1628 6754 11924 0.8 6.OOE-61 AA596033.1 EST-HUMAN rin66h09.sl NCI CGAP Larl Homo sapiens cDNA done IMAGE: 1088897 3' 1655 6780 11953 0.6 5.OOE-61 4506008 NT Homo saplens protein phosphatase 1. regulatory subunit 10 (PPP1 R1 0) mRNA 3000 8152 13252 1.9 5.OOE-61 AL163279.2 NT Homo sapiens chromosome 21 segment HS21 C079 3114 8263 13367 0.8 5.OOE-61 A13020632.1 NT Homo sapiens mRNA for KIAA0825 protein, partial cds 3161 8310 13422 1.9 5.OOE-61 4502166 NT Homo sapiens arnylold beta (A4) precursor protein (protease nexin-l I, Alzhelmer disease) (APP), mRNA 3899 9034 1.7 5.0OE-611 AJ229041.1 NT Homo saplens 959 kb config between AML1 and CBRI on chromosome 21q22; segment 113 1434 6561 1,3 4.OOE-61 W28189.1 EST-HUMAN 43c.5 Human retina cDNA randomly primed sublibrary Homo sapiens cDNA 4119 9245 14329 1.1 3.OOE-61 BE396279.1 EST HUMAN 601309785F1 N1H MGC 44 Homo sapiens cDNA done IMAGE:3631220 5' 490 5655 16778 0.5 2.OOE-61 8922829 NT Homo sapiens hyeothefical protein FL.1 11026 (FLA 1026), mRNA 1194 6326 11482 1.4 2.OOE-61 BE168410.1 EST HUMAN QV3-HT0513-060400-147- d01 HT0513 Homo saplens cDNA 1194 6326 11483 1.4 2.OOE-61 BE168410.1 EST HUMAN QV3-HT0513-060400-147- d01 HT0513 Homo sapiens cDNA 1642 6768 11939 1 2.OOE-61 N53039.1 EST-HUMAN yv53dl 1.sl Soares fetal liver spleen 1NFLS Homo saplens cDNA done IMAGE:246453 3' similar to gb125444 60S RIBOSOMAL PROTEIN L35A (HUMAN); 2109 1220 12429 0.5 2.OOE-61 4758003 NT Homo sapi ns calmegin (CLGN), mRNA 2604 7694 1.2 2.OOE-61 BE384973.1 EST HUMAN 601276829F1 N1H MGC 20 Homo sapiens cDNA done IMAGE:3617767 5' 428 5595 0.9 1.0OE-61 AL163203.2 NT Homo sapiens chromosome 21 segment HS21C003 756 5908 11056 1.3 1.OOE-61 5453829 NT Homo sapiens origin recognition complex, subunit 2 (yeast homologlike (ORC2L) mRNA 1377 6505 11670 1.1 1.OOE-61 AL1 63203.2 NT Homo sapions chromosome 21 segment HS21C003 1731 6854 1.0 1.OOE-61 U32657.1 NT Human polymorphic trinudeodde repeat In X-linked refinifis pigmentosa (RP3) gene region 1814 6933 12122 1.6 1.OOE-61 6005983 NT Homo sapiens zona pelludda glycoprotein 3A (sperm receptor) (ZP3A), mIRNA 2150 7260 12467 0.5 1.OOE-61 AW827281.1 EST-HUMAN xnl 1 b09.yl NCLCGAP_L15 Homo saplens cDNA done IMAGE:2693369 5'simiiar to contains element MSR1 repetitive element; 2804 7956 13065 1.7 1.OOE-61 BE386363.1 EST HUMAN 601273513F1 NIH MGC 20 Homo sapiens cDNA done IMAGE:3614667 5' 3330 8474 13587 0.9 1.OOE-61 7662319 NT Homo saplens KIAA0806 gene product (K1AA0806), mRNA Page 114 of 196 Table 4

3671 8810 13904 1.5 1.OOE-61 BE174455.1 EST HUMAN QV2-HT0577-140300-077906 HT0577 Homo sapiens cDNA 4339 9462 14551 1.0 1.OOE-61 4759249 NT Homo sapiens TRAF family member- assodated NFKB activator (TANK) mRNA 4339 9462 14552 1.0 1.OOE-61 4759249 NT Homo sapiens TRAF family member- associated NFKB activator (TANK) MRNA 4751 9862 14954 7.6 1.OOE-61 AW298181.1 EST& HUMAN Ul-H-BWO.ajt-b-08-0-Ut. sl NCI_PGAP_Sub6 Homo sapiens cDNA done IMAGE:2732871 3' 4751 9862 14955 7.6 1.0OE-61 AW298181.1 EST HUMAN Ul-H-SWO-ajt-b-08-0-Ul. sl NC(_CGAP_Sub6 Homo saplens eDNA done IMAGE:2732871 3' 4878 9985 15067 0.9 1.0OE-61 AL163210.2 NT Homo sapiens chromosome 21 segment HS21C010 4451 9571 14670 0.8 8.0OE-62 AA830420.1 ESTHUMAN oc66h11.sl NCI_PGAP_GCBI Horno sapiens cDNA done IMAGE:1354725 Ysimilar to SW:POL-MLVRK P31795 POL POLYPROTEIN:

3462 8603 13716 0.8 7.OOE-62 P17480 SWISSPROT NUCLEOLAR TRANSCRIPTION FACTOR 1 (UPSTREAM BINDING FACTOR 1) (U13F.1) (AUTOANTIGEN NOR-90) 2969 8120 1.1 6.OOE-62 U094110.1 NT Human dric finger protein ZNF131 mRNA, partial ods 410 5578 10715 1.5 5.OOE-62 A1950528.1 EST-HUMAN wx5le07.xl NCI_CGAP_Lu28 Homo saplens cDNA done IMAGE:2547204 3' similar to SW:GG9-HUMAN Q08379 GOLGIN-95. xontains element MER22 repetitive element; 2356 7458 12664 1.2 5.OOE-62 A.1271735.1 NT Homo saplens Xq pseudoautosomal region; segment 112 2356 7458 12665 1.2 5.OOE-62 AJ271735.1 NT Horno sapiens Xq pseudoautosomal region: segment 112 3372 8515 13622 2.2 5.00IE-62 4506758 NT Homo saplens ry@nodine receptor 3 (RYR3) mRNA 4233 9357 14439 1.7 5.OOE-62 AA431093.1 EST-HUMAN zw78e09.sl Soaresjesfij_NHT Horno sapiens cDNA clone IMAGE:782344 X sim ar to SW:1NIRDQ_RAT P47245 NARDILYSIN; 822 5972 11129 1.2 4.OOE-62 AW161479.1 EST-HUMAN au71d03j11 Schnelder fetal brain 00004 Homo sapiens cDNA done iMAGE:2781701 V similar to gb:M37104 ATP SYNTHASE COUPLING FACTOR 6, MITOCHONDRIAL PRECURSOR(HUMAN); 822 5972 11130 1.2 4.OOE-62 AW161479.1 EST-HUMAN au71d01y11 Schnelder fetal brain 00004 Homo sapiens cONA done IMAGE.2781701 5, similar to gb:M37104 ATP SYNTHASE COUPLING FACTOR 6, MITOCHONDRIAL PRECURSOR(HUMAN); 823 5972 11129 1.6 4.OOE-62 AW161479.1 EST-HUMAN au71 d03.yl Schneider fetal brain 00004 Homo sapiens cDNA done IMAGE.2781701 5' similar to qb:M37104 ATP SYNTHASE COUPLING FACTOR 8, MITOCHONDRIAL PRECURSOR(HUMAN); 823 5972 11130 1.6 4.OOE-62 AW161479.1 EST HUMAN au71c103.yl Schnelder fetal brain 00004 Homo sapiens cDNA done IMAGE:2781701 5' similar to qb.M371104 ATP SYNTHASE COUPLING FACTOR 6, MITOCHONDRIAL PRECURSOR(HUMAN); 1446 6573 0.9 4.OOE-62 AA311281.1 EST-HUMAN EST182043 Jurkat T-cells V Homo sapiens cDNA T end 2409 7508 12715 1.4 4.OOE-62 A1827900.1 EST-HUMAN wfl 2b08.xl Soares-NFL.. GBC-Sl Homo saplens cDNA clone IMAGE:2350359 3'similar to gb:X57138_mal HISTONE H2B.2 (HUMAN); 2409 7508 12716 1.4 4.OOE-62 A1827900.1 EST-HUMAN wl12b08.xl Soares- NFLTGBC_Sl Horno sapiens cDNA clone IMAGE:2350359 3'sImilar to gb:X57138 mal HISTONE H2B.2 (HUMAN); 2821 7972 13074 1.1 4.OOE-62 L10391.1 NT Rabbit flavin-containing monooxygenase FM03 mRNA, complete cds 3353 8497 6.6 4.OOE-62 4557887 NT Homo saplens keratin 18 (KRT18) mRNA 4947 110052 2.0 4.OOE-62 A.1243213.1 NT Homo saplens partial 5-HT4 receptor gene, exons 2 to 5 68 5275 10400 1.1 3.0012-62 4557794 NT Homo saplens neurofibrornin 2 (bilateral acoustic neuroma) (NF2) mRNA 1^ Page 115 of 196 Table 4

Page 116 of 196 3008 8160 13260 1.0 3.OOE-62 AB040909.1 NT Horno sapiens mRNA for KIAA1476 protein, partial cds 3008 8160 13261 1.0 3.OOE-62 AB040909.1 NT Homo sa-plens mRNA for KIAA1476 protein, partial ods 3640 8779 13872 1.9 3.OOE-62 X52858.1 NT Human cyclophilin-r61ated processed pseudogene 1211 6342 11501 0.5 2.0OE-62 AL163284.2 NT Homo sapiens chromosome 21 segment HS21 C084 1028 6168 11323 1.2 1.OOE-62 AF248540.1 NT Homo sapiens intersectin 2 (SH3D1 B) mRNA, complete cds 1526 6653 11820 2.5 1.0012-62 L7881 0.1 NT Horno, sapiens ADPIATIP carder protein (ANT-2) gene, complete cds 1758 6879 12060 1.0 1.OOE-62 AA625207.1 EST-HUMAN af7Oel 1.rl Soares-Nhi- IMPu_S1 Homo sapiens cDNA done IMAGE:1047404 5'similar to WRI(O11-112.1 CE03453; 2884 8035 13138 1.1 1.OOE-62 AL039044.1 E 1 ST_HUMAN DKFZp566F104-rl 566 (synonym: hfkd2) Horno sapiens cIDNA clone DKFZp566F1104 5' 4426 9547 14640 1.3 1.0OE-62 8923201 NT Homo sapiens hypothetical protein FLJ20212 (FU20212), mRNA 335 5516 10641 0.7 9.OOE-63 AW816405.1 EST-HUMAN QV4-ST0234-181199-037405 ST0234 Homo sapiens cIDNA 2297 7401 0.6 9.OOE-63 C18159.1 EST-HUMAN Cl 8159 Human placenta cIDNA (TFujiwara) Honno sapiens cDNA clone GEN-558C10 5 3955 9088 14170 7.4 9.OOE-63 A13002348.2 NT Homo saplens mRNA for KIAA0350 protein, partial cds 3955 9088 14171 7.4 9.OOE-63 A13002348.2 NT Horno sapiens mRNA for KIAA0350 protein, partial cds 2296 7400 12609 0.6 8.0012-63 4557734 NT Homo sapiens moncamine oxidase A (MAOA), nuclear gene encoding mitochonddal protein, mRNA 2322 7425 12634 0.8 8.OOE-63 5031810 NT Horno sapiens. 112-inducible T- ced kinase (ITK), mRNA 3415 8557 13666 3.8 8.OOE-63 AF1 98349.1 NT Gallus gallus Dach2 protein (Dach2) mRNA, complete ods 3415 8557 13667 3.8 8.OOE-63 AF198349.1 NT s Dach2 protein (Dach2) mRNA, complete cds 4168 9294 14375 3.4 8.OOE-63 AL163268.2 NT Horno saplons chromosome 21 segment HS21 C068 913 6059 0.6 7.OOE-63 A1872137.1 EST HUMAN wm55gl 1.xl NCI CGAP Ut2 Homo saplens cIDNA clone IMAGE:2439908 3, 3279 8424 13533 1.0 4.OOE-63 AL163278.2 NT Horno sapiens chromosome 21 segment HS21 C078 1893 7010 12198 0,7 3.OOE-63 AB018260.1 NT Homo sapiensmIRNA for KIAA0717 protein, partial cds 2753 7837 13038 1.3 3.OOE-63 J00310.1 NT Human Met-tRNA-i gene 1 2791 6349 11510 3.1 3.OOE-63 6005963 NT Homo saplens dric finger protein 144 (Mel-1 p) (ZNF144), mRNA 4445 9565 14661 3.2 3.OOE-63 AW954734.1 EST HUMAN EST366804 MAGE resequences, MAGC Horno sapiens cDNA 184 5378 10504 1.1 2.OOE-63 U07804.11 NT Human DNA topolsornerase 1 mRNA, partial cds 191 5385 10512 0.6 2.OOE-63 4885226 NT Homo saplens eyes absent (Drosophila) h molog 2 (EYA2), mIRNA 489 5654 1.4 2.OOE-63 4557624 NT Homo sapiens glutamate-cystelne ligase (gamma-glutamylcysteine synthetase), catalytic (72.8kID) (GLCLC) mIRNA 809 5960.11115 1.8 2.0OE-63 7657042 NT Horno saplens Down syndrome candidate region 1 (DSCR1), mRNA 1547 6674 11844 0.9 2.OOE-63 AB030388.1 NT Horno saplens RHCE mIRNA for Rh blood CE group antigen polypepfide, complete cds 1547 6674 11B45 0.9 2.OOE-63 AB030388.1 NT Homo saplens RI-ICE mRNA for Rh blood CE group andgen polypeptide, complete cds 3119 8268 13373 1.7 2.OOE-63 4502166 NT Horno sapiens amyloid beta (A4) precursor protein (protease neyin-l I, Aizheimer disease) (APP), mRNA 3248 8395 13502 1.8 2.OOE-63 AF109718A NT Homo saplens chromosome 3 subtelomeric region 3831 8968 14067 1.9 2.OOE-63 L39891.1 NT Horno saplens polycystic kidney disease-assodated protein (PKD1) gene, complete cds 4760 9871 14966 1.1 2.OOE-63 AFI 11167.2 NT Homo saplens jun dimedzadQn protein gene, partial cds; dos gene, complete cds; and unknown gene Table 4

4246 9371 14450 2.9 1.OOE-63 F08485.11 EST HUMAN HSWVD1 11 normalized Infant brain CDNA Homo sapiens eDNA done c-zvdl 1 4246 9371 14451 2.9 1.0012-63 F08485.11 EST-HUMAN HSWVD1 11 normalized Infant brain cIDNA Homo saplens CIDNA done c-zvd 11 1307 6436 11602 0.6 9.OOE-64 H30687.1 EST HUMAN yo78c02.rl Soares adult brain N2b4H12155Y Homo sapiens cIDNA, clone IMAGE: 184034 5' 1307 6436 11603 0.6 9.OOE-64 H30687.1 EST HUMAN yo78c02.rl Soares adult brain N2b41,11355Y Horno saplens cDNA clone IMAGE:184034 5' 1030 6170 2.7 8.OOE-64 BE280796.1 EST HUMAN 601155232F1 N1H MGC 21 Homo saplens cIDNA done IMAGE:3139038 5, 4674 9786 5.2 8.OOE-64 AL163213.2 NT Homo sapiens chromosome 21 segment HS21 C01 3 3486 8627 1.0 7.OOE-64 BE394321.1 EST HUMAN 601311455F1 N1H MGC 44 Homo sapiens cDNA done IMAGE:3633204 5' 4625 9739 14835. 2.4 7.OOE-64 4507490 NT Homo sapiens thimet oligopepfidase 1 (THOP1) mRNA 4625 9739 14836 2.4 7.OOE-64 4507490 NT Homo saplens thimet oligopepddase 1 (THOP1) mRNA 1692 6816 11995 0.6 6.0012-64 A1651992.1 EST-HUMAN w1J51c07.xl NCI_PGAP- GC6 Homo sapiens cIDNA done IMAGE:2309220 3'sImilar to gb:M15182 BETA-GLUCURONIDASE PRECURSOR (HUMAN); 1692 6816 11996 0.6 6.OOE-64 A1651992.1 EST HUMAN wb51e07.xl NCI WAP_QC6 Homo sapiens cIDNA done iMAGE:2309220 Ysimilar to 82351 gb:M15182 BET-GLUCURONIDASE PRECURSOR (HUMAN); 2675 7762 12962 1.1 6.OOE-64 BE252937.1 EST HUMAN 601117525F1 N111_1VIGC__16 Homo sapiens cIDNA done IMAGE:3357966 5' 3084 8239 13333 3.7 6.OOE-64 AW026445.1 EST-HUMAN w03e03.xl NCI CGAP 13m23 Homo saplens cIDNA done IMAGE:2529436 3' 3084 13334 3.7 6.0012-64 AW026445.1 EST HUMAN wv13e03.xl NCI_PGAP---13m 3 Homo sapiens cIDNA done IMAGE:2529436 3' 803 5954 11106 0.8 5.OOE-64 AF231 919.1 NT Homo sapiens chromosome 21 unknown mRNA 803 5W 11107 0.8 5.0OE-64 AF231919.1 NT Homo sapiens chromosome 21 unknown mRNA 1402 6529 11699 0.9 5.OOE-64 L40933.11 NT Homo sapiens phosphoglucomutaserelated protein (PG1VIRP) gene. complete cds 1402 6529 11700 0.9 5.OOE-6.4 L40933.11 NT Homo sapiens phosphoglucomutase-related protein (PG1VIRP) gene, complete cds 1683 6807 11989 0.6 5.OOE-64 U89358.1 NT Human 1(3)mbt protein homolog mRNA, oomplete cds 2796 6592 11767 1.0 5.OOE-64 7662205 NT Homosaplens KIAA0618 gene product (K1AA0618), mRNA 2796 65U2 11768 1,0 5.OOE-64 7662205 NT Horno sapiens KIAA0618 gene product (K1AA0618), mRNA 3876 9OU 14107 5.6 5.OOE-64 AF01 7433.1 NT Homo sapiens putative transcription factor CR53 (CR53) mRNA, partial ods 2151 7261 12468 1.4 3.OOE-64 C18895.11 EST HUMAN Cl 8895 Human placenta cIDNA (TFujiwara) Homo sapiens cDNA done GEN-569E02 5' 1072 6210 11363 0.9 2.OOE-64 AA609940.1 EST HUMAN afO9d08.sl Soares testis NHT Homo sapiens cDNA.done IMAGE:1031151 3' 1376 6504 11669 1.3 2.OOE-64 4757701 NT Homo saplens e1F4E-like cap- binding protein (4El-IP) mRNA 2478 7576 0.6 2.OOE-64 A1927030.1 EST HUMAN wo87b01.xl NCI_CGAP_KJdl 1 Homo saplens cDNA done IMAGE:2462281 3' similar to contains element Ll repetitive element; 2484 7581 12784 1.1 2.OOE-64 AL163246.2 NT Horno sapiens chromosome 21 segment HS21 C046 2484 7581 12785 1.1 2.OOE-64 AL1 63246.2 NT Homo sapiens chromosome 21 segment HS21 C046 3101 8251 13355 2.6 2.00IE-64 4504068 NT Homo saplens glutamic-oxaloacetc transaminase 2, mitochonddal (aspartate aminotransferase 2) (GOT2), nuclear gene encoding mitochondrial protein, mRNA 3719 8856 13948 1.3 2.OOE-64 AW958145.1 EST HUMAN EST370215 MAGE resequences, MAGE.Homo sapiens cIDNA 3719 8856 13949 1.3 2.OOE-64 AW958145.1 ESTHUMAN EST370215 MAGE resequences, MAGE Homo saplens cIDNA 258 5446 10571 0.6 1.OOE-64 AF231919.1 NT Homo sapiens chromosome 21 unknown mRNA 1740 6863 12040 2.1 1.OOE-64 A1929419.1 EST_HUMAN au60c01.xl Schnelder fetal brain 00004 Homo sap!ens cIDNA done IMAGE:2519136 3' similar to gb:L2169Q_cdsl PROTHYMOSIN ALPHA (HUMAN);contains element MSR1 repetitive element; Page 117 of 196 Table 4

3466 8607 13720 5,6 1.OOE-64 AF196779.1 NT Homo saplens transcription factor IGHM enhancer 3, JM1 1 protein, JM4 protein, JM5 protein, M54 protein, JMIO protein, A4 differentlation-dependent protein, triple LIM domain protein 6, and synaptophysin genes, complete cds. and L-type calcium channel a> 3536 8677 13780 1.3 1.0OE-64 AF228527.1 NT Homo sapiens TRIAD3 mRNA, partial cds 3536 8677 13781 1.3 1.OOE-64 AF228527.1 NT Homo sapiens TRIAD3 mRNA, partial cds 4142 9268 2.7 1.OOE-64 8922772 NT Horno sapiens hypothetIcal protein FLJ10923 (FU10923), mRNA 1598 6725 11895 0.5 9.OOE-65 8922772 NT Homo saplens hypothedcal protein FLJ10923 (FU10923), mRNA 2230 7337 12549 0.9 9.OOE-65 X8921 1.1 NT H.saplans DNA for endogenous retroviral like element 2230 7337 12550 0.9 9.OOE-65 X8921 1.1 NT H.sapiens DNA for endogenous retroviral like element 1880 6998 3.0 6.0OE-65 AA550929.1 EST HUMAN n186d1O.s11 NCI - CGAP_Prl l Homo sapiens cIDNA done IMAGE:999379 similar to gb:K03002 60S RIBOSOMAL PROTEIN L32 (HUMAN); 615 5773 10894 0.9 5.0OE-65 AF064604.1 NT Homo saplens KE03 protein mRNA, partial cds ' 1331 WO 11626 0.6 5.OOE-65 7661951 NT Homo saplens K1AA01 56 gene product (K1AA01 56), mRNA 1331 WO 11627 0.6 5.OOE-65 7661951 NT Homo saplens KIAA01 56 gene product (K1AA01 56), mIRNA 2110 7221 12430 1.0 5.OOE-65 A13033768.1 NT Homo sapiens hIPAD-colony1O mRNA for peptidylarginine delminase type 1, complete cds 2336 7438 12648 1.0 5.OOE-65 BE311673.1 EST-HUMAN 601142861 F1 NIH MGC_14 Homo sapiens cIDNA done IMAGE:3506774 5' 3217 8365 13476 1.9 5.OOE-65 4507 NT Homo sapiens ubiquidn specific protease 13 (isopepfidase T-3) (USP13) mRNA 3217 8365 13477 1.9 5.OOE-65 4507848 NT Homo sapiens ubiquifin specific protease 13 (isopepfidase T-3) (USP1 3) mRNA 186 5380 10507 1.1 4.OOE-65 AL1 20419.1 EST-HUMAN DKFZp761G108-rl 761 (synonym: hamy2) Homo sapiens cIDNA clone DKI'Zp761G108 5, 728 5882 11023 0,5 4.OOE-65 A1266468.1 EST-HUMAN qm46e01.xl Soares_piacentp_8togweeks2NbHP8togW Homo sapions cIDNA clone IMAGE:1891800 3' 728 5882 11024 0.5 4.OOE-65 A1266468.1 EST-HUMAN qm46e01.xl Soares_ptacenta-8togweeks-2NbHP8togW Homo saffiens cDNA clone IMAGE:1891800 X 1062 6200 11354 0.6 4.OOE-65 4826735 NT Homo sapiens fragile X mental retardation, autosornal homolog 1 (FXIR1), mRNA 1470 6597 11772 3.0 4.OOE-65 4506636 NT Homo sapiens ribosomal protein L34 (RPL34) mRNA 2288 7393 12600 1.0 4.OOE-65 BE221469.1 EST-HUMAN hu25e04.xl NCI CGAP Mall 5 Homo saplens cDNA clone IMAGE:3171102 3' 2288 7393 12601 1.0 4.OOE-65 BE221469.1 EST HUMAN hu25e04.xl NCI CGAP Me115 Homo sapiens cDNA done IMAGE:3171102 3' 5138 10233 15307 1.0 4.OOE-65 9055269 NT Horno, sapiens low density lipoproteln receptor related protein-deleted in tumor (LRPDIT), mRNA 5138 10233 15308 1.0 4.OOE-65 9055269 NT Horno sapiens low density lipoprotein receptor related protein-deleted In tumor (LRPDIT), mRNA 1212 7868 1.8 3.OOE-65 X78932.1 NT H.sapions HW9!nRNA for zinc finger protein 1780 6901 12089 1,1 3.OOE-65 A1000692.1 EST-HUMAN ov23103.sl Soares_testis-NI-IT Homo sapiens cDNA clone IMAGE:1 638173 3, similar to contains element IVISR1 repetitive element., 3239 8386 13494 1.4 3.OOE-65 4504950 NT Horno, sa lens faminin, beta 1 (LAMB1), mRNA 8799 13893 1.0 3.OOE-65 A1000692.1 EST-HUMAN ov23f01s11 Soares-tesds_NHT Horno sapiens cIDNA clone IMAGE:1638173 3' similar to contains element MSR1 repetitive element; JC c Page 118 of 196 Table 4

4551 9670 14760 1.4 3.OOE-65 6912385 NT Homo saplens rab6 GTPase activating protein (GAP and centrosome-associated) (GAPCENA), mRNA 528 5692 10814 1.3 1.0OE-65 7657495 NT Homo sapiens putative Rab5 GDPIGTP exchange factor homologue (RABEX5), mRNA 1994 7110 12313 0.9 1.0OE-65 AB040946.1 NT Homo sapiens mRNA for K1AA1 513 protein, partial cds 3326 8470 13564 0.9 1.0OE-65 BE466681.1 EST-HUMAN hz2469-xl NCI CGAP GC6 Homo saplens cDNA done IMAGE:3208888 3' 3917 9051 14138 2.1 1.0OE-65 4504082 NT Homo saplens glypican 4 (GPC4) mRNA 3917 9051 14139 2.1 1.0OE-65 4504082 NT Homo sapiens glypican 4 (GPC4) mRNA 4112 9238 14321 2.4 1.0OE-65 AW029340.1 EST_HUMAN wxOgcOg.xl NCLCGAP Gas4 Homo sapiens cDNA done IMAGE:2543152 3, 4112 9238 14322 2.4 1.OOE-65 AW029340.1 EST-HUMAN wxO9cO9.xl NCI CGAP Gas4 Homo sapiens cDNA done IMAGE:2543152 3' 4415 9535 14624 1.1 1.OOE-65 AW136725.1 EST-HUMAN UPH-Bil-adm-a-1 1-0-Ul. si NCLWAP-SuW Homo sapiens cDNA clone IMAGE:2717108 3' 4415 9535 14625 1.1 1.0OE-65 AW136725.1 ESI_HUMAN Ul-H-Bil-adm-a-1 1-0-Ul. si NCLWAP-SuW Homo sapiens cDNA clone IMAGE:2717108 3, 5273 10396 0.5 9.OOE-66 A1.160311.1 NT Novel human gene mapping to chomosome 22 5273 10397 0.5 9.ODE-66 AL160311.1 NT Novel human gene mapping to chomosome 22 1332 6461 11628 0.9 9.ODE-66 5031980 NT Horno sapiens 26S proteasome- assodated padl homoiog (POH I) mRNA 1332 6461 11629 0.9 9.0012-66 5031980 NT Homo sapiens 26S proteasome- assodated padl homolog (P01-11) mRNA 1468 6595 1.5 9.OOE-66 M87299.1 NT Human transposon-like element, partial 2480 7578 12779 1.0 9.OOE-66 8923943 NT Homo sapiens transcription factor NRF (NRF), mRNA 2480 7578 12780 1.0 9.OOE-66 8923943 NT Homo saplens transcription factor NRF (NRF), mRNA 3826 8963 14061 0.9 9.OOE-66 M72393.1 NT Human calcium-dependent phospholipid-binding protein (PLA2) mRNA, complete ods 3826 8963 14062 0.9 9.OOE-66 M72393.1 NT Human calcium-dependent phospholipid-binding protein PLA2) mRNA, complete cds 4591 9705 14798 0.9 8.OOE-66 AA424304.1 ESTHUMAN zv90c05.rl Soare NhHMPu S1 Horno saplens cDNA done IMAGE:767048 5 4269 9394 14476 1.2 6.OOE-66 A1924653.1 EST-HUMAN wn57b07.xl NCI-CGAP- Lulg Homo saplens cDNA done IMAGE:2449597 Ysimilar to WP.FI5G9.4A CE18595; 4269 9394 14477 1.2 6.OOE-66 A1924653.1 ESHUMAN wn57h07.xl NCI.CGAP-1.09 Homo saplens cIDNA done IMAGE:2449597 Ysimilar to WRF15G9.4ACE18595; 4269 9394 14478 1.2 6.OOE-66 A1924653.1 EST HUMAN wn57b07.xl NCLCGAP_Lul g Horno sapiens cDNA done IMAGE:2449597 Ysimilar to WRF15G9.4A CE18595; 1344 6472 11639 0.8 5.OOE-66 BE064410.1 ESYH-UMAN RC4.13T0311-141 19"11 - h06 BT0311 Homo saplens eDNA 773 5925 11074 0.8 4.OOE-66 6679816 NT Mus musculus fragile X mental retardation syndrome 1 homolog (Fmrl), mRNA 2235 7342 12554 0.7 4.OOE-66 X89211.1 NT H.sapiens DNA for endogenous retroAral like element 2425 7524 1.3 4.OOE-66 AJ223364.1 NT Homo sapiens germ-line DNA upstream of Jkaepa locus 1408 6535 11707 8.9 3.OOE-66 4502098 NT Homo saplens solute carrier family 25 (mitochonddal carrier; adenine nudeotide translocator), member 5 (SLC25AS), nuclear gene encoding mitochondrial protein, mRNA 1408 6535 11708 8.9 3.OOE-66 4502098 NT Homo saplens solute carder family 25 (mitochonddal carrier; adenine nudeotide translocator), member 5 (SLC25A5), nuclear gene encoding mitochondrial protein, mRNA T (9_ Page 119 of 196 Table 4

1939 7056 12249 0.8 3.OOE-66 N55323.1 EST-HUMAN yz27g112xl Soares multiple - sderosis-2NbHMSP Homo sapiens cIDNA clone IMAGE:284326 5'simiiartoSW:H.2Bl-TIGCAP35068HISTONEH2B.1/H2B.2.[2]PIR:B56612; 1939 7056 12250 0.8 3.OOE-66 N55323.1 EST-HUMAN yz27912.rl Soare_mulfiple- scierosis 2NbHMSP Homo sapiens cIDNA clone IMAGE:284326 6similar to SW:H2BljiGCA P35068 HISTONE H2B.1/H2B.2. [2] PIR:1356612; 1939 7056 12251 0.8 3.OOE-66 N55323.1 EST-HUMAN yz27g12.rl Soares- mulfiple-sderosis_2NbHMSP Homo sapiens cIDNA clone IMAGE:284326 Csimilar to SW:H2Bl-TIGCA P35068 HISTONE H2B.1/H2B.2.[21 PIR:1E156612; 3079 8230 13329 5.5 3.00IE-66 7662223 NT Homo sapiens KIAA0649 gene product (K1AA0649), mRNA 5255 10369 1.0 2.00IE-66 7657334 NT Homo sapiens Misshapen/NIK-related kinase (MINK), mIRNA 5255 10370 1.0 2.0012-66 7657334 NT Homo saFe-ns Misshapen/NIK-related kinase (MINK), mIRNA 416 5205 10306 0.9 2.OOE-66 4505524 NT Homo saplens origin recognition complex, subunit 5 (yeast homologlike (ORC51---)mRNA, and translated products 416 5205 10307 0.9 2.OOE-66 4505524 NT Homo saplens origin recognition complex, subunit 5 (yeast homologlike (ORC51---)mRNA, and translated products 1784 6904 12092 0.7 2.00IE-66 AL163301.2 NT Homo sapiens chromosome'l segment HS21 Cl 01 2944 8095 13201 1.0 2.00IE-66 X65859.1 NT H.sapiens euclogene for the low affinity IL-8 receptor 3975 9107 14189 0.9 2.OOE-66 AF108389.1 NT Homo sapiens sodium/calcium exchanger isofonil NaCa3 (NCM) mRNA, complete cds 4556 9674 14765 12.7 2.OOE-66 AJ133267.2 NT Homo saplens HLA-B gene for human leucocyte antigen 8 455 9 74 14766 12.7 2.OOE-66 AJ133267.2 NT Homo sapiens HLA-B gene for human 1e922!4e antigen B 4829 9937 0.8 8.OOE-67 M78158.1 EST-HUMAN EST01750 Subtracted Hippocampus, Stratagene (cat. #936205) Homo sapiens cIDNA done HHCPN31 similar to Ll repetitive element 376 5582 10716 2.1 7.OOE-67 AW162232.1 EST HUMAN au75d02.xl Schnelder fetal brain 00004 Homo saplens cIDNA done IMAGE:2782083 X similar to qb:M37104 ATP SYNTHASE COUPLING FACTOR 6, MITOCHONDRIAL PRECURSOR(HUMAN); 1360 6488 11654 1,0 7.OOE-67 AA383416.1 EST HUMAN EST96812 Testis 1 Horno sapiens cIDNA. 5' end similar to similar to C. elegans hypothetical protein, cosmid ZK353 1535 6661 11828 1.0 7.OOE-67 W85947.1 EST-HUMAN zh56b05.rll Soares- fetaifiver-spleen-1NFLS-Sl Homo sapiens cDNA clone IMAGE:416049 5' 1535 6661 11829 1.0 7.00IE-67 W85947.1 EST HUMAN zh56JJ05xl Soares-fetal- liveLspleen-1 WLS-S1 Homo sapiens cIDNA clone IMAGE:416049 5' 1988 7103 12305 1.1 7.OOE-67 7657243 NT Homo sapiens Inositol 1,3,4- triphosphate 516 kinase (ITPK1), mRNA 1988 7103 12306 1.1 7.OOE-67 7657243 NT Homo sapiens Inositol 1,3,4- tdphosphate 516 kinase (ITPK1), mRNA 2779 5582 10716 2.4 7.OOE-67 AW162232.1 EST-HUMAN au75d02.xl Schnelder fetal brain 00004 Homo sapiens cIDNA clone IMAGE:2782083 3, similar to gb:M37104 ATP SYNTHASE COUPLING FACTOR 6, MITOCHONDRIAL PRECURSOR(HUMAN); 547 5710 10829 1.3 6.00IE-67 X68968.1 NT H.sapiens mRNA for acetyl-CoA carboxylase 778 5930 11079 0.5 6.OOE-67 Z17227.1 NT Homo saplens mIRNA for transmebrane receptor protein 1252 6381 11540 0.9 6.OOE-67 Y14320.1 NT Homo sapiens PMP69 gene, exons 3, 4,5,6 & 7 31311 13388 1.2 6.OOE-67 4506434 NT Homo saplens retinoblastorna 1 (including osteosarcoma) (R131) mRNA Page 120 of 196 Table 4

3391 8533 -13638 1.2 6.OOE-67 4507332 NT Synapsin Ill (SYN3) mRNA, and translated productS mRNA, and translated products 3391 8533 --36-39 1.2 6.OOE-67 4507332 NT Homo sapiens Synapsinffi SYN3) 21 segment HS21C001 4035 9163 14246 1,3 6.OOE-67 AL163201.2 NT Horno sapiens chromosome HS21C001 21 4035 9163 14247 1.3 6.OOE-67 AL163201.2 NT segment Homo sapiens chromosome (DKIFZP434P211), mRNA 4607. 9721 14815 3.4 6.OOE-67 7657020 NT HomosapiensIDKFZp434P2111 protein (DKIFZP434P21 1), mRNA 4607 9721 14816 3.4 6.OOE-67 7657020 NT Homo saplens WFZp434P211 protein 13 (isopeptidase T-3) (USP13) MRNA 5125 9988 2.1 6.OOE-67 4507848 NT Homo saelens ubiquitin specific protease beta locus, TCRBV7S3A2 to TCRBV12S2 region 3184 8333 13445 2. 5.OOE-67 AF009660.1 NT)r 1306 6435 11601 0.6 4.0 1 OE-67 R9081 9.1 EST HUMAN yn02d11.rl Soares adult brain N2b41-IBS5Y Homo sapiens cIDNA done IMAGE:167253 5' 0.9 33OE-67 AA333768.1 EST_HUMAN EST37903 Embryo, 9 week Homo sapiens cDNA Cend 82 5775 10897 1.1 3.OOE-67 BE064410.1 EST HUMAN RC4-BT0311-141 199-01 11- h06 BT031 1 Horno sapiens cIDNA 782 3407 8549 13657 3.1 3.OOE-67 AW86915 AliAEST HUMAN MR3-SNO066M0500-008- f01 SNO065 Morno sapiens cIDNA 7 9710 14802 NCI-Ci3AP-Lu24 Homo sapiens cDNA clone IMAGE:3183136 Ysimilar to 9 W6g09.xl 046 5374 10499 0,7 2.0OE-67 BE348354.1 EST HUMAN WPY231-11 1.9 CE09617; 5976 11136 2.0 2.OOE-67 AW816405.1 EST HUMAN C1V4-ST0234-181199-037405 ST0234 Homo sapiens cIDNA 8277 double stranded RNA activated protein kinase (PKR) gene, exons 2a, 2, 3.

Homo sapiens 1089 62 12146 0.6 2.0OE-67 AF167460.1 NT and 4 1841 6959 0.5 2.OOE-67 BE303037.1 EST_HUMAN ba72905.yl N11-1_1v1GQj20 Homo sapiens cDNA done IMAGE:2905976 C similar to TR:094892 094892 KIAA0798 PROTEIN.; Homo sapiens cDNA done IMAGE:2905976 5'similar to 1841 6959 12147 0.5 2.OOE-67 BE303037.1 EST HUMAN ba72g05.y11 NIM_MGC_20 2381 7483 12685 1.2 2.OOE-67 4758795 NT- TR:094892 094892 KIAA0798 PROTEIN.; g3422 8564 13676 3.9 2.OOE-67 AA625755.1 EST HUMAN Homo sapiens developmentally regulated GT12-binding protein 1 (DRG1), mRNA 3921 9055 14142 2.3 2.OOE-67 AL1 63300.2 NT zu91901.sl Soar s $tis NHT Homo sapiens cIDNA done IMAGE:745392 3' 4716 9828 1.1 2.OOE-67 AA41853Sel EST HUMAN Homo saplans chromosome 21 segment HS21 Cl 00 zv92nO9.rl Soares_NhHMPu S1 Morno, sapiens cDNA done IMAGE:767296 51 amytold beta (A4) precursor protein (protease nexin-li, Alzheirner disease) Homo sapiens 253 5441 10568 1.5 1.OOE-67 4502166 NT (APP), mRNA 3794 8931 14024 5.0 8.OOE-68 AA209456.1 EST-HUMAN zq82h1O.rl Stratagene 1INT neuron (#937233) Homo sapiens ciDNA done IMAGE:648163 5' similar to SW:SA\-SULAC Q07590 SAV PROTEIN.; hNT neuron (#937233) Horno sapiens ciDNA done IMAGE:648163 51 3794 8931 14025 5.0 8.OOE-68 AA209456.1 EST HUMAN - 1849 6W7 10386 -0.8 6.OOE-68 AW503842.1 EST HUMAN - 66 5265 10387 0.9 5.OOE-68 AA304324.1 EST HUMAN zq82h10xl Stratagene 56 5265 10386 0.9 5.0OE-68 AA304324.1 EST HUMAN similar to SW:SA\_SULAC Q07590 SAV PROTEIN.:

57 5265 11087 1.0 5.OOE-68 AA304324.1 EST-HUMAN - 57 C26-5 11088 1-0387-1.0 -70-OE-68 AA304324.1 EST HUMAN Ul-HF-t3NO-alb-c- 07-0-Ul. 1 IH WC_50 Homo sapiens cDNA clone IMAGE:3078924 S' 7864 11088 0.9 5.OOE-68 AF231919.1 NT EST17103 Aorta endothelial cells, TNF alpha-treated Homo sapiens cDNA 5' end 785 7864 11104 0.9 5.OOE-6 919.1 NT EST17103 Aorta endothelial cells, TNF alpha-treated Homo sapiens cDNA Vend 8022 5953 1110 1A.3.0OE-68 AF23191 9.1 NT EST17103 Aorta endothelial cells, TNF alpha-treated Homo sapiens cDNA 5' end 0 b7C8 11105 7a 4 EST17103 Aorta endothelial calls, TNF alpha-trea dHomosapienscDNA5'end 8022 5953 1.1 known mRNA Horno saplens chromos me un Homo saplens chromosome 21 unknown mRNA Horno sapiens chromosome 21 unknown mRNA.

ms chromoscime 21 unknown mRNA Page 121 of 196 Table 4

Page 122 of 196 3108 8258 13362 2.6 5.OOE-68 A13037852.1 NT Homo sapiens mRNA for KIAA1431 protein, partial ods 4900 10007 17.2 4.OOE-68 P04406 SWISSPROT GLYCERAL-DEHYDE 3-PHOSPHATE DEHYDROGENASE, LIVER 3611 8750 13844 5.6 3.OOE-68 AF236082.1 NT Mus musculus G-protein coupled receptor GPR73 (Gpr73) mRNA, complete cds 2832 7983 12.3 2.OOE-68 D00522.1 NT Cricetulus longicaudatus mRNA for EF- 1 alpha, complete cds 4583 9699 14793 1.7 2.OOE-68 ABOO8681.1 NT Homo sapiens gene for activin receptor type I I B, complete cds 72 5278 10405 1.3 1.0OE-68 4505222 NT Homo sapiens meningloma (disrupted In balanced translocation) 1 (MN1), mRNA 293 5479 10610 3.2 1.OOE-68 AW816405.1 EST HUMAN QV4-ST0234-181199-037- f05 ST0234 Homo sapiens cIDNA 2205 7314 12526 1.3 1.OOE-68 AF1 19860.1 NT Homo sapiens PR02014 mRNA, complete cds 2205 7314 12527 1.3 1.OOE-68 AF1 19860.1 NT Homo saplens PR02014 mRNA, complete cds 2728 7812 13018 1.0 1.OOE-68 AW451832.1 EST HUMAN Ul-H-B]3-alk-f-01-0-Ul. sl NCI-CGAP-Sub5 Homo sapiens cDNA clone IMAGE:2737272 3' 3928 9062 14149 1.0 1.OOE-68 BE296032.1 EST HUMAN 601177002F1 NIH MGQ_17 Homo sapiens cIDNA clone IMAGE:3532344 5' 4954 10059 15130 1.0 1.0OE-68 AA897343.1 EST HUMAN a147g12.sl Soares NFL T GBC S1 Homo sapiens cIDNA done IMAGE:1460518 X 19 5228 10329 0.6 9.OOE-69 5031976 NT Homo sapiens pre-B-cell colonyenhancing factor (PBEF) mRNA 19 5228 10330 0.6 9.OOE-69 5031976 NT Homo sapiens pre-B-cell colony- enhancing factor (PBEF) mRNA 1011 6151 11304 0.6 9.OOE-69 5031980 NT Homo sapiens 26S proteasome- associated padl homolog (P0H1) mRNA 1011 6151 11305 0.6 9.OOE-69 5031980 NT Homo sapiens 26S proteasome- associated padl homolog (P0H1) mRNA 4037 9165 14250 0.8 9.OOE-69 4757867 NT Homo sapiens waf mudne sarcoma viral oncogene homolog B1 (BRAF) mRNA 3340 8484 1.2 8.OOE-69 A.1237744.1 NT Homo sapi ns RIBI1R gene (partial), exon 12 509 5673 0.6 4.OOE-69 A1873630.1 EST-HUMAN wrn26hl 1.xl NCI CGAP UW Homo sapiens cIDNA done IMAGE:2437125 3' 380 5586 10719 1.0 3.OOE-69 BE258012.1 EST-HUMAN 601110371 F1 NIH MGC 16 ilomo sapiens cIDNA clone IMAGE:3351352 5 596 5754 10872 0.6 3.OOE-69 AF221712.1 NT Homo sapiens Smad- and Olf- Interacting zinc finger protein mRNA, partial cds 1536 6662 1.4 3.OOE-69 T80514.1 EST HUMAN yd08a02xl Soares Infant brain 1 NIB Homo sapiens cDNA done IMAGE:24880 5'similar to SP:A48836 A48836 SPEW 111=EGF REPEAT-CONTAINING FIBROPELLIN-LIKE PROTEIN SEA URCHIN; 2325 7428 0.9 3.OOE-69 5729910 NT Homo saplens lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) mRNA 3990 9122 14206 0.9 3.OOE-69 A1765888.1 EST-HUMAN wh66g08.xl NCI CGAP Kidl 1 Homo sapiens cDNA done IMAGE:2385758 3, 124 5566 10702 1.0 2.OOE-69 AF160252.1 NT Homo sapiens KIAA0553 protein gene, complete cds; and alphallb protein gene, partial cds 124 5566 10703 1.0 2.OOE-69 AF160252.1 NT Homo sapiens KIAA0553 protein gene, complete cds; and alphallb protein gene, partial cds 398 5566 10702 1.7 2.OOE-69 AF160252.1 NT Homo sapiens KIAA0553 protein gene, complete cds; and alphallb protein gene, partial cds 398 5566 10703 1.7 2.OOE-69 AF160252.1 NT Homo sapiens KIAA0553 protein gene, complete cds; and alphallb protein gene, partial cds 1842 6960 12148 1.2 2.OOE-69 BE257857.1 EST-HUMAN 601109444F1 NIM_MGQ_16 Horno sapiens cIDNA clone IMAGE:3350074 5 2813 7964 2.7 2.OOE-69 AA431157.1 EST HUMAN zw71902.rl Soares tesd!_NHT Homo saplens cDNA done IMAGE:781682 5, 1675 6799 11977 0.9 1.0OE-69 AF053768.1 NT Rattus noryegicus brain specific cortactin-binding protein CBP90 mRNA, partial cds 2284 7939 12597 0.6 8.OOE-70 AA230303.1 EST-HUMAN ncl3d12.rl NCI_WAP_Prl Homo sapiens cIDNA done IMAGE:1008023 4277 9402 14486 2.2 8.0OE-70 1.77566.1 NT Homo sapiens DGS-1 mRNA, Yend 1771 6 0.7 7- A1497807.1 ES1.HUMAN tm89f01.xl NCI WAP,13m25 Homo sapiens cDNA done IMAGE:2165305 3' OOE-70 Table 4

1771 6892 12080 0.7 7.OOE-70 AW97807.1 EST-HUMAN tm89f01.xl NCI_PGAP Bm25 Homo saplons cDNA clone IMAGE:2165305 3, 1888 7006 12192 0.6 7.OOE-70 AA282955.1 EST HUMAN zt11 5h04.rl NCI_PGAP GCB1 Homo sapiens cIDNA done IMAGE:713239 5' 2018 7131 1.3 7.OOE-70 5031668 NT Homo sapiens tumor suppressor deleted In oral cancer-related 1 (DOC-1 R) mRNA 4132 9 14339 3.9 7.OOE-70 4757723 NT Horno sapiens adenylate cyclase 3 (ADCY3) mRNA 853 6002 11162 0.7 6.OOE-70 4502166 NT Homo saplens amylold beta (A4) precursor protein (protease ne)dn-li, Alzhelmer disease) (APP), mRNA 2090 7201 12406 1,4 6.OOE-70 M30938.1 NT Human Ku (p701p80) subunit mRNA, complete ods 2461 7560 12764 1.0 6.OOE-70 8923899 NT Homo sapiens CMP-Nacetyineuraminic acid synthase (LOC55907), mRNA 2505 75Z5 12800 0.7 5.OOE-70 7662307 NT Homo saplens KIAA0792 gene product (K1AA0792), mRNA 2505 7945 12801 0.7 5.0012-70 7662307 NT Homo sapiens KIAA0792 gene product (K1AA0792), mRNA 1571 6697 11864 0.9 3.0012-70 BE071796.1 EST-HUMAN RCO-ST0522-071299-01 1- a12 BT0522 Homo sapiens cDNA 1571 6697 11865 0.9 3.OOE-70 BE071796.1 EST HUMAN RCO-BT0522-071299-01 1 - all 2 BT0522 Homo saplens cDNA 674 5830 10958 4.5 2.OOE-70 N42161.1 EST HUMAN yy07a10xl Scares melanocyte 2Nb)-IM Horno sapiens cDNA clone IMAGE:270522 5' similar to SW:1D31-11-RAT P29266 3-HYDROXYISOBUTYRATE DEHYDROGENASE PRECURSOR; 674 5830 10959 4.5 2.0012-70 N42161.1 EST HUMAN yy07a10xl Scares melanocyte 2NbHM Homo sapiens cDNA clone IMAGE.270522 Tsimilar to SW:1331-11-RAT P29266 3-HYDROXYISOBUTYRATE DEHYDROGENASE PRECURSOR; 689 5844 10981 0.7 2.OOE-70 A1246899.1 EST-HUMAN qx51 h011.xl NCI CGPanl Homo sapions cDNA done IMAGE:2004913 3' 1004 6144 11298 0.6 2.OOE-70 8923669 NT Homo sapiens hypothetical protein FLJ20758 (FLJ20758), mRNA 1167 6301 11456 0.7 2.OOE-70 7661983 NT Homo saplens K(AA0193 gene product (K1AA0193), mRNA 1167 6301 11457 0.7 2.OOE-70 7661983 NT Homo, sapiens K1AA01 93 gene product (K1AA011 93), mRNA 1387 6514 11680 1.0 2.OOE-70 BE46731 1.1 EST-HUMAN hz64c12.xl NCI WAP_Lu24 Homo saplens eDNA done IMAGE:3212758 3' 1708 6831 12011 0.8 2.0012-70 AL163202.2 NT Homo sapiens chromosome 21 segment HS21 C002 2272 7378 1.3 2.OOE-70 AA054010.1 EST HUMAN 048904.rl Soares retina N2b4HR Homo sapiens cDNA done IMAGE:380214 Csimilar to SW:GAGLI-ITI.1A P03345 GAG POLYPROTEIN; 2344 7446 12653 2.9 2.OOE-70 AW961822.1 ESI-HUMAN EST373895 MAGE resequences, MAGG Homo sapiens cDNA 2344 7446 12654 2.9 2.OOE-70 AW961822.1 ES7_HUMAN EST373895 MAGE resequences, MAGG Homo saplens cDNA 3963 9095 14180 4.0 2.OOE-70 M691811.1 NT Human nonmusde myasin heavy chain-B (MY1-110) mRNA, partial cds 3347 8491 3.0 1.OOE-70 4507476 NT Homo sapions transgiutaminase 3 (E polypepfide, protein-glutamin"amma glutamyltransfemse) (TGM3) mRNA 3469 8610 13722 1.0 9.OOE-71 AW936999.1 EST_HUMAN CM21-DT0032-151299-055- h12 DT0032 Horno saffiens cDNA 1743 6866 12044 0.6_ 8.OOE-71 AA594019.1 EST-HUMAN nn28e07.si NCI_CGAF_Gasl Homo saplons cDNA done IMAGE:1085220 3' 3717 8W 13946 0.9 7.OOE-71 BE244676.1 EST-HUMAN TCBAP2E0520 Pediatric preB cell acute lymphoblastic leukernia Baylor-HGSC project=TCBA Homo saplens cDNA done TCBAP0520 1818 657 12127 1.0 6.OOE-71 7705404 NT Homo saplens home-binding protein (HEBP), mRNA 1818 6937 12128 1.0 6.OOE-71 7705404 NT Homo s51ens heme-binding protein (HEBP) mRNA 2576 7669 0.8 6.OOE-71 BE266255.1 ESTHUMAN 601191652F1 NIM_MElC 7 Homo, sapiens cDNA done IMAGE:3535549 5' 2163 7272 12483 1.3 5.OOE-71 AF056322.1 NT Homo saplens SP1100-HIVIG nuclear autoandgen (SP100) mRNA, complete ods 4030 9158 14242 1.4 5.OOE-71 AW816405.1 EST-HUMAN OV4-ST0234-181199-037- f05 ST0234 Homo saplons cDNA 5144 10239 15314 3.2 5.OOE-71 A182M6.1 ESTHUMAN wil 8h10.xl NCI CGAP Utl Homo sapiens cDNA done IMAGE:2425315 3' Page123of196 Table 4

97 5304 10431 1.1 4.OOE-71 4507592 NT Homo sapiens tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10) mRNA 347 5528 10655 39.0 4.OOE-71 AF157626.1 NT Equus caballus glyceraidehyde- 3-phosphate dehydrogenase mRNA, partial cds 347 5528 10656 39,0 4.OOE-71 AF157626.1 NT Equus caballus glyppraidehyde- 3-phosphate dehydrogenase mRNA, partial cds 2850 8001 13098 0.9 4.OOE-71 7705414 NT Homo saplens hookli protein (HOOK1), mRNA 2850 8001 13099 0.9 4.OOE-71 7705414 NT Homo sapiens hookl protein (HOOKI), mRNA 2857 8008 13107 1,6 4.0OE-711 4505880 NT Horno sapiens plasminogen (PLG) mRNA 4330 9453 14541 3,4 4.0012-71 AF056322.1 NT Horno sapiens SP100-HMG nuclear autoanfigen (SP100) mRNA, complete cds 4913 10020 15099 5.0 4.0012-71 7657602 NT Homo sapiens putative hernebinding protein (SOUL), mRNA 1210 11500 0.9 2.OOE-71 AL163206.2 NT Homo sapiens chromosome 21 segment HS21C006 622 5781 10903 0.7 1.OOE-71 A1077927.1 EST_HUMAN oyl5e03.sl Soares_senescent - fibroblaste_NbHSF Homo sapiens cDNA clone IMAGE:1665916 3'sImilar to contains LOR112 LOR1 repetitive element:

926 6073 11231 0.7 1.OOE-71 7706281 NT Homo sapiens neuronal cell deathrelated protein (LOC51616), mRNA 1084 6222 11373 1.4 1.OOE-71 AF205890.1 NT Horno sapiens disabled-2 gene, exons 2through 15 and complete cds 1317 6446 11612 3.8 1.0OE-71 AF012872.1 NT Homo sapiens phosphafidylinositol 4-kinase 230 (p14K230) mRNA, complete cds 2036 7149 12363 1.2 1.OOE-71 AB017007.1 NT Homo sapiens PMS2L16 mRNA, partial cds 2036 7149 12354 1.2 1.OOE-71 AB017007.1 NT Homo sapiens PMS2LI6 mRNA, partial cds 2661 7750 12948 1.8 1.OOE-71 7657153 NT Homo sapiens hairylenhancor-of- split related vAth YRM modflike (HEYL), mRNA 3457 8598 13711 1.2 1.OOE-71 AF119665.1 NT Homo saplens Inorganic pyrophosphatase mRNA, complete cds 3546 8687 13788 4.7 1.OOE-71 AF246219.1 NT Homo sapiens SNARE protein kinase SNAK mRNA, complete cds 3546 8687 13789 4.7 1.OOE-71 AF246219.1 NT Homo sapiens SNARE protein kinase SNAK mRNA, complete ods 3597 8736 13830 0.9 1.OOE-71 BE122850.1 EST-HUMAN 0215 Human Epidermal Keradnocyte Subtraction Library- Upregulated Transcripts Homo sapiens cDNA clone 02 15 Wsimilar to Horno taplens chromosome 19 3597 8736 13831 0,9 1.ODE-71 BE122850.1 EST-HUMAN 0:2.15 Human Epidermal Keradnocyte Subtraction Library. Upregulated Transcripts Homo saplens cIDNA done 02 15 Wsimilar to Homo sapiens chromosome 19 3681 8820 13913 1.9 1.OOE-71 AF218904.1 NT Homo saplens attractin precursor (ATRN) gene, exon 1 4370 9492 14582 1.9 1.OOE-71 D28476.1 NT Human mRNA for KIAA0045 gene, complete cds 401 5569 10705 1.2 9.OOE-72 A1857635.1 EST-HUMAN M95g03.xl NCLWAP_Lulg Homo sapiens cIDNA done IMAGE:2423188 Ysimilar to TR:086705 086705;HYPOTHETICAL 38,6 KID PROTEIN, contains Alu repetitive element; 401 5569 10706 1.2 9.OOE-72 A1857635.1 EST-HUMAN wk95903.xl NCJ-CGAP_Lulg Homo sapiens cIDNA done IMAGE:2423188 3'similar to TR:086705 086705 HYPOTHETICAL 38.6 KID PROTEIN.;contains Alu repetitive element; 4023 9151 14232 5.2 7.OOE-72 4501866 NT Homo sapiens aconitase 2, mitochonddal (AC02), nuclear gene encoding mitocondrial protein, mRNA 4023 9151 14233 5.2 7.OOE-72 4501866 NT Horno saplens awnitase 2, mitochonddal (AC02), nuclear gene encoding mitocondrial protein, mRNA 4023 9151 14234 5.2 7.OOE-72 4501866 NT Homo sapiens aconitase 2, mitochondrial (AC02), nuclear gene encoding mitocondrial protein, mRNA 1122 6259 0.9 5.OOE-72 L1 1645,1 NT Homo sapiens alpha-tubulin mRNA, complete cds --W0-4 10528 1.1 4.OOE-72 8922990 NT Homo sapiens hypothetical protein FU l 1316 (FU l 1316), mRNA -A Page 124 of 196 Table 4

885 6033 4.9 3.OOE-72 AA723823.1 EST HUMAN ah$3a06.sl Soaress NHT Horno sapiens cDNA clone 1310290 X Human chondroitin suillate proteoglycan versican VO splice-vadant precursor peptide mRNA, 1139 6275 11426 2.1 3.OOE-72 U16306.1 NT complete cds Human chondrolfin sulfate proteoglycan versican VO splice-variant precursor peptide mRNA, 1139 6275 11427 2.1 3.OOE-72 U16306.1 NT complete cds 3037 8189 13291 10.5 3.OOE-72 AJ229043.1 NT Homo sapiens 959 kb config between AMLI and CBR1 on chromosome 21q22, segment 313 3241 8388 13495 2.6 3.OOE-72 8923548 NT Horno sapiens hypothetical protein FLJ20585 (FLJ20585), mRNA TCR V delta 2-C alpha =T-cell receptor delta and C alpha fusion gene (alternatively spliced, 3750 8888 13977 2.5 3.OOE-72 S77589.1 NT splice Junction) [human, precursor B-cell line REH, mRNA Partial, 211 ntl 4835 9943 15032 0.9 3.OOE-72 A1654337.1 EST-HUMAN wb31a08.xl NCI CGAP GC6 Homo saplens cIDNA clone IMAGE:2307254 3' a183c102.sl Soares_parathyrold-tumor_NbHPA Homo saplens cDNA done IMAGE: 1387395 2030 7143 12344 0.9 1.OOE-72 AA846225.1 EST HUMAN X 1443 6570 11745 1.2 9.0015-73 AW374968.1 EST-HUMAN MRO-CT0063-071099-002- h11 1 CTO063 Homo sapiens cDNA 5102 10198 15278 1.0 9.OOE-73 AW867850.1 EST HUMAN MRO-SNO040-050500.002- 401 SNO040 Homo sapiens cDNA ws55c06.xl NCI-CGAF_9m25 Homo sapiens cIDNA done IMAGE:2501098 3'sImflar to 1022 6161 11314 1.0 8.OOE-73 AW071755.1 EST HUMAN TR:Q59050 Q59050 HYPOTHETICAL PROTEIN MJ1656.; 1399 6526 11695 1.1 8.OOE-73 A1024877.1 EST HUMAN ov39h08.xl Soares testis NHT Homo sapiens cDNA clone iMAGE:1639743 3' 1118 6255 11407 0.8 7.OOE-73 8923290 NT Homo sapiens hypothetical protein FLJ20309 (FLJ20309), mRNA 3261 8408 13515 1.1 7.OOE-73 AL163206.2 NT Horno saplens chromosome 21 segment HS21 C006 4863 9970 1.6 7.OOE-73 AL163282.2 NT Homo saplens chromosome 21 segment HS21 C082 152 5348 0.8 6.OOE-73 AL163218.2 NT Homo saplens chromosome 21 segment HS21C018 HSBIOE082 STRATAGENE Human skeletal muscle cDNA library, cat. #936215. Homo 1247 6376 11534 1.4 3.OOE-73 F00548.1 EST HUMAN sapiens cDNA done 1 0E08 HS131 0E082 STRATAGENE Human skeletal muscle cDNA library, cat. #936215. Homo 1247 6376 11535 1.4 3.OOE-73 F00548.1 EST HUMAN sapiens cDNA done 1 0E08 833 5982 11142 0.6 2.OOE-73 AF139897.1 NT Homo sap] ns BASSI (BASSI) mRNA, partial ods 1902 7020 0.5 2.OOE-73 AW898081.1 EST HUMAN RC3-NNO066-270400-011-c04 NNO066 Homo sapiens cIDNA 2251 7357 1.1 2.OOE-73_ U01317.1 NT Human beta globin region on chromosome 11 3144 8293 13401 3.5 2.OOE-73 4502582 NT Homo sapiens caspase 8, apoptosis- related cysteine protease (CASP8) mRNA Homo saplens Parkinson disease (autosomal recessive, juvenile) 2, parkin (PARK2), 3503 8645 13753 1.0 2.OOE-73 7669539 NT transcript variant 3, mRNA Homo sapiens Parkinson disease (autosomal recessive, juvenile) 2, parkin (PARK2), 3503 WS 13754 1.0 2.OOE-73 7669539 NT transcript variant 3, mRNA 2434 7 F3-3 12739 0.9 1.OOE-73 AF198349.1 NT s Dach2 protein (Dach2) mRNA, complete cds ws60d04.xl NCLWAP-Bm25 Homc, saplens cDNA done IMAGE:2501575 Ysimilar to 2073 7185 12388 1,0 9.OOE-74 AW054828.1 EST HUMAN TR:01 3541013541 4EBINDING PROTEIN 1.

723 5877 11017 1.4 8.OOE-74 4557426 NT Homosa ens CD394We 4 (CD39L4) mRNA 1906 7023 12211 1,1 7.OOE-74 AJ001689.1 Homo saplens NKG2D gene, exon 10 IAL163246.2 8431 13539 OOE-74 NT Homo sapiens chromosome 21 segment HS21 C046 V) C Page 125 of 196 Table 4

1106 6244 11397 0.9 6.0012-74 AF109907.11 NT Homo sapiens S164 gene, partial cds; PS1 and hypothetical protein genes, complete ods; and S171 gene, partial cds 1609 6736 11905 1.0 6.OOE-74 AW263177.1 ESTHILIMAN xn78g07.xl Soares NFL T GBC S1 Homo sapiens cDNA done IMAGE:2700636 X 2268 7374 12582 3.6 6.OOE-74 BE388260.1 EST HUMAN 601283521F1 NIH MGQ_44 Homo sapiens cIDNA done IMAGE:3605453 5 2268 7374 12583 3.6 6.OOE-74 BE388260.11 EST-HUMAN 601283521F1 N11-11-MGC 44 Homo sapiens cDNA done IMAGE:3605453 5' 2834 7985 13085 1.4 6.OOE-74 AW014039.1 EST-HUMAN U]-H-BIO-aah-h-03-0-Ul. sl NCi-CGAP-Subl Homo saplens cDNA clone IMAGE:2709365 3' 2834 79'5 13086 1.4 6.OOE-74 AW014039.1 EST HUMAN Ul-H-BIO-aah-h-03-0-Ul. sl NCl-WAP_Subl Homo sapiens cDNA clone IMAGE:2709365 3, 7985 3652 8791 13884 2.6 6.OOE-74 BE048846.1 EST HUMAN hr54e111.xl NCI CGAP Wdll 1 Homo sapiens cDNA clone IMAGE:3132332 3' "91 3652 8791 13885 2,6 6.OOE-74 BE048846.1 ESI_HUMAN hr54el 1.xl NCI CGAP Kidll 1 Homo saplens cDNA done IMAGE:3132332 3, 4826 9934 15024 1.2 6.0012-74 H09912.1 EST HUMAN ym05g03xl Soares Infant brain INIB Homo sapiens cDNA clone IMAGE:46895 S' 887 51465 11193 0.9 5.OOE-74 AW020986.1 EST HUMAN dfl7c09.yl Morton Fetal Cochlea Horno sapiens cDNA done IMAGE:2483704 5, 6035 2669 7756 5.2 5.OOE-74 AW362756.1 EST-HUMAN PMO-CTO289-271099-001-h07 CTO289 Homo sapiens cDNA 278 10595 0.6 4.OOE-74 D87675.1 NT Homo sapiens DNA for arnylold precursor protein, complete cds 834 5983 11143 1.7 4.OOE-74 AB028942.1 NT Homo sapiens mRNA for KIAA101 9 protein, partial cels 1919 7036 12224 0.9 A13026898.11 NT Homo sapiens DNA, DLEC1 to ORCTI.4 gene region, section 112 (DLEC1, ORET-1.3, ORCT11-4 genes, oomplete cds) 1919 7036 12225 0.9 4.OOE-74 AB026898.1 NT Homo sapiens DNA, DLEC1 to ORCTIL4 gene region, section 112 (DLEC1, ORCTO, ORCTL4 genes, complete cds) 2027 7140 12340 1.6 4.OOE-74 4506192 NT Homo sapiens proteasome (prosorne, macropain) subunit, beta type, 1 (PSMB1) mRNA 2027 7140 12341 1.6 4.OOE-74 4506192 NT Homo sapiens proteasome (prosome, macropain) subunit, beta type, 1 (PSMB1) mRNA 2085 7197 12402 1.2 4.OOE-74 AB032994.1 NT Homo sapiens mRNA for K1AA11 168 protein, partial ods 2377 7479 12681 1.0 4.OOE-74 AJ006976.1 NT Homo sapiens PLP gene 3052 8203 13304 4.4 4.OOE-74 AJ006976.1 NT Homo sapiens 121-P gene 3483 8624 13736 0.9 4.OOE-74 AL1 63210.2 NT Homo saplens chromosome 21 segment HS21 C01 0 3973 9 TO-5 14187 1.3 4.OOE-74 AL163247.2 NT Homo sap ens chromosome 21 segment HS21 C047 4457 W-7 14674 1.6 4.OOE-74 7662183 NT Homo sapiens KIAA0569 gene product (K1AA0569), mIRNA 4512 9631 14724 0,8 4.OOE-74 Z117227.1 NT Homo sapiens mRNA for transmebrane receptor protein 5006 10108 15176 3.8 4.0012-74 4504326 NT Homo sapiens hydroxyacylCoenzyme A dehydrogenase/3-ketoacyi-Coenzyme A thiolaselenoyl-Coenzyme A hydratase (trifunctional protein), beta subunit (HADHB) mRNA 5006 10108 15177 3.8 4.OOE-74 4504326 NT Homo sapiens hydroxyacyl- Coenzyme A dehydrogenase/3-ketoacyi-Coenzyme A thiciaselenoyi-Coenzyme A hydratase (trifunctional protein), beta subunit (HADHB) mRNA 2849 8000 13096 1.1 3.OOE-74 AA234789.1 EST-HUMAN zr78b1O.rl Scares- NhHMPu - S1 Homo sapiens cDNA done IMAGE:669499 5'simiiar to gb:X0410Q_odsl CALCIUM-DEPENDENT PROTEASE, SMALL (HUMAN); 2849 8000 13097 1.1 3.OOE-74 AA234789.1 EST HUMAN zr78b10.rl Soares - Nhi- IMPu-SI1 Homo saplens cDNA done IMAGE:669499 Esimilar to gb:X04106 odsI CALCIUM-DEPENDENT PROTEASE, SMALL (HUMAN); 3203 8351 2.2 3.OOE-74 A1796960.1 EST HUMAN we25c07.xl NCI_PGAF_Lu24 Homo sapiens cDNA done IMAGE:2342124 3'similar to TR:Q113537 Q13537 SIMILAR TO POGO ELEMENT.; X Page 126 of 196 Table 4

3703 8000 13096 4.8 3.OOE-74 AA234789.1 EST-HUMAN zr78b1O.rl Soares_NhiIMPu S1 Homo saplens cDNA done IMAGE:669499 5'similar to gb:X0410Q_cdsl CALCIUM-ISEPENDENT PROTEASE, SMALL (HUMAN); 3703 8000 13097 4.8 3.OOE-74 AA234789.1 EST-HUMAN zr78b1O.rl Soares_NhHMPt_SI Homo sapiens cIDNA done IMAGE.669499 5'similar to gb:X0410p_cdsl CALCIUM-DEPENDENT PROTEASE, SMALL (HUMAN); 942 6089 11246 126.2 2.OOE-74 7669491 NT Homo sapiens glycoraidehyde-3- phosphate dehydrogenase (GAPD), mRNA 942 6089 11247 126.2 2.OOE-74 7669491 NT Homo saplens glyceraidehyde-3- phosphate dehydrogenase (GAPD), mRNA 1158 6293 11448 1,0 2.OOE-74 AF020092.1 NT Human endogenous retrovirus HERV-K-T47D 1224 6354 11518 1,2 2.0OE-74 A)950528.1 EST-HUMAN vwSle07.xl NCLCGAP_Lu28 Homo sapiens cDNA done IMAGE:2547204 Ysimilar to SW:GG9_HUMAN Q08379 GOLGIN-95.:contains element MER22 repetitive element; 1577 6703 11872 1.1 2.OOE-74 4885198 NT Homo saplens epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) (EGFR) mRNA 1577 6703 '11873 1.1 2.OOE-74 4885198 NT Homo sapiens epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) (EGFR) mRNA 2558 7652 12855 1.1 2.OOE-74 A1557280.1 EST HUMAN PT2.1 15 G1 1.r tumor2 Homo sapiens cDNA 3' 4937 10043 15114 2.0 2.0012-74 A1-355092.1 NT Novel human gene mapping to chomosome 22 4937 10043 15115 2.0 2.OOE-74 AL355092.1 NT Novel human gene mapping to chomosome 22 4942 10048 15120 1,9 2.0OE-74 J02963.1 NT Human platelet glycoprotein lib mRNA, Yend 47 5257 10373 1.0 1.OOE-74 7657334 NT Homo sapiens MisshaperVNIK-related kinase (MINK), mRNA 334 5515 10640 1.2 1.OOE-74 AW816405.1 EST HUMAN QV4-ST0234-181199-037f05 ST0234 Homo saplens cONA 491 5656 10779 1.2 1.OOE-74 8922829 NT Homo saplens hypothetical protein FUll 1026 (F1J1 1026), mRNA 497 5661 10784 0.9 1.00674 X02344.1 NT Homo saplens beta 2 gene 586 5746 10863 1.4 1.00674 4508020 NT Homo sapiens 7Jnc finger protein 259 (ZNF259) mRNA 983 6128 11283 0.7 1.0OE-74 A1-163246.2 NT Homo saRlens chromosome 21 segment HS21 C046 2179 7288 12500 2.2 1.0OE-74 A13002059.1 NT Homo sapiens DNA for Human P2^. complete ods 3100 8250 13354 6.0 1.0OE-74 4758697 NT Homo sapiens mannosidase, alpha, class 2A, member 1 (MAN2A1), mRNA 3887 9023 14116 4.6 1.00674 AL163268.2 NT Homo sapiens chromosome 21 segment HS21 C068 3974 9106 14188 0.9 1.OOE-74 BE083080.1 EST-HUMAN RC2-13T0642-270300019406 BT0642 Homo saelens cDNA 4170 9296 14377 0.9 1.0OE-74 BE467769.1 EST-HUMAN hz73h08.xl NCI---C_Lu24 Homo saplens, cDNA done IMAGE,3213663 Ysimilar to WP:130511.12 CE17351; 5112 10208 15286 1.2 1.OOE-74 D83327.1 NT Homo sapiens WRR1 mRNA, pardal cds 2607 7697 1.5 8.00675 AF176228.1 NT Homo sapiens DNA cytosine-5 methyttransferase 313 (DNMT3B) mRNA, complete ods 2273 7379 12587 0.9 6.OOE-75 A1817415.1 EST-HUMAN wk38a08.xl NC(_CGAP_Pr22 Homo saptens cDNA clone IMAGE.2417654 Ysimilar to gb:M14123 cds4 RETROVIRUS-RELATED POL POLYPROTEIN (HUMAN); 5128 10223 0.9 6.OOE-75 AA789285.1 EST-HUMAN aj28c06.sl Soaree_tesds-NHT Homo sapiens cIDNA done 1391626 3 similar to TR:W 5377 Q15377 Y-CHROMOSOME RNA RECOGNITION MOTIF PROTEIN; 107 5310 10435 1.1 4.00675 BE081333.1 EST_HUMAN OV1-BT0632-210200-07"02 BT0632 Homo sapiens cDNA 451 5617 1.2 4.OOE-75 N36757.1 EST-HUMAN yx90h08.0 Soares melanocyte 2NbHM Homo saplens cDNA done IMAGE:269055 6 1728 6851 12030 0.5 4.00675 AW897230.1 EST-HUMAN CM0-NN0057-11 SUOO-335- al 1 NNO057 Homo saplens cDNA 2818 7969 13072 4.7 4.OOE-75 BE409464.1 EST-HUMAN 601303866F1 NIH_MGC 21 Homo saRlens cIDNA done IMAGE:3638344 5' 986 6131 11286 1.0 3.OOE-75 AF157623.1 NT Homo sapiens HTRA sedne protease (PRSS1 1) gene, complete cds 1 r----9-8-7 -6131 11286 0.8 3.OOE-75 AF157623.1 NT Homo sapiens HTRA sedne protease (PRSS1 1) gene, complete ods 1_ Page 127 of 196 Table 4

1795 6915 12101 0.7 3.OOE-75 AB01 1153.1 NT Horno sapiens mRNA for KIAA0581 protein, partial cds 2065 7177 12384 1,1 3.OOE-75 4507334 NT Horno sapiens synaptojanin 1 (SYNJ1), mRNA 2373 7475 12676 1.3 3.OOE-75 4759153 NT Homo sapien synaptosomakassociated protein, 29k1D (SNAP29) mRNA 2402 7501 12708 1.0 3.OOE-75 AA042813.1 EST HUMAN zk53c07.sl Soares_pregnant-uterus-NbHPU Homo saplens cDNA clone I MAGE:486540 3, 2988 8140 13243 1.2 3.OOE-75 AL163201.2 NT similar to gb:X65857_cdsl OLFACTORY RECEPTOR-LIKE PROTEIN HG1VIP07E (HUMAN); 3152 8301 13409 1.3 3.OOE-75 AB01 1153.1 NT Horno saplens chromosome 21 segment HS21 C001 3306 8451 13562 1.0 3.OOE-75 M72393.1 NT Homo sapiens mRNA for KIAA0581 protein, partial cds 3306 8451 13563 1.0 3.OOE-75 M72393.1 NT Human calcium-dependent phospholipid-binding protein (PLA2) mRNA, complete cds 4077 9204 14291 1.4 3.00IE-75 D87675.1 NT Human calcium-dependent phospholipid-binding protein (PLA2) mRNA, complete cds 4336 W9 14547 1,0 3.OOE-75 7662421 NT Homo sapiens DNA for arnyloid precursor protein, complete cds 1 Homo sapiens KIAA0971 pro in (K1AA0971), mRNA xg60d02.xl NCl-WAP_1.1M Homo sapiens ODNA clone IMAGE:2632707 Ysimilar to 2255 7361 12569 1.8 1.OOE-75 AW168135.1 EST HUMAN contains PT117All PTR7 repetitive clement; 2916 8067 13176 3.2 1.OOE-75 X52221.1 NT H.sapiens ERCC2 gene, exons 1 & 2 (partial) cIDNA done IMAGE:2307163 3'similar to Homo wb30b10.xl NCI-PGAP_GC6 sapiens 38 5248 10357 1.5 9.0012-76 A1652648.1 EST HUMAN TR:075235 075235 TRAP1 wb30b10.xl NCLWAP_PC6 Homo sapiens cDNA done IMAGE:2307163 Ysimilar to 38 5248 10358 1.5 9.OOE-76 A1652648.1 EST HUMAN TR:075235 075235 TRAP1; infant brain cIDNA Homo sapiens cIDNA done c-zvc06 214 5407 10530 0.9 9.OOE-76 Z45834.11 EST HUMAN HSCZVC061 normalized A85b07.sli Soares-fetaLliver-spleerLl NFI-SSI Homo sapiens cIDNA clone IMAGE:447541 2364 7466 11227 1.2 9.OOE-76 AA702415.1 EST-HUMAN 3 923 6016 11228 0.6 8.OOE-76 4504374 NT Homo sapiens H factor 1 (complement) (HF1) mRNA 923 6070 0.6 8.0012-76 4504374 NT Homo sapiens H factor 1 (complement) (HF1) mRNA 2880 8031 13135 1.1 8.00IE-76 7706724 NT Homo sapiens mediator (Sur2), mRNA Homo sapiens dihydrollpoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex) (DLD) 759 5911 11059 1.4 7.OOE-76 5016092 NT mRNA 3254 8401 13507 2,6 7.OOE-76 AF056490.1 NT Homo sapiens cAMP-specific phosphodlesterase BA (PDE8A) mRNA, partial cds 3260 8407 13514 7.1 7.OOE-76 4505052 NT Homo sapiens lymphocyte antigen 75 (LY75) mRNA, and translated products Homo sapiens core-binding factor, runt domain, alpha subunit 2: translocated to, 1; cyclin D- 3293 8439 13549 1.1 7.0OE-76 4757915 NT related (CBFA2T1) mRNA Homo sapiens seplaptedn reductase (7,8-dihydrobioptedn:NADP+ oxidoreductase) (SPR) 4275 9400 14483 4.3 7.OOE-76 4507184 NT mRNA Horno sapiens seplaptedn reductase (7,8-dihydrobioptedn:NADP+ oxldoreductase) (SPR) 4275 9400 14484 4.3 7.OOE-76 4507184 NT mRNA 1214 6344 6.7 6.OOE-76 BE396253.1 EST HUMAN 601312019F1 NII-l_ly1GC 44 orno sapiens cIDNA done IMAGE:3658757 5' 1899 7017 12205 1.3 5.OOE-76 D63874.1 NT Human mRNA for HIVIG-11, complete ods 1899 7017 12206 1.3 5.OOE-7 D638. NT Human mRNA for HMG-1, complete cds 1899 7017 12207 1.3 5 E_76 D63874.1 NT Human mRNA for I-IMGA, complete ods 1581 6707 11877 1.0 3.OOE-76 4503476 NT Homo sapiens eukaryofic translation elongation factor 1 beta 2 (EEF1 B2) m NA Page 128 of 196 Table 4

1581 6707 11878 1.0 3.OOE-76 4503476 NT Homo saplens eukaryodc translation elongation flactor 1 beta 2 (EEF11 B2) mRNA 280 5467 10597 1.2 2.OOE-76 D84295.1 NT Human mRNA for possible protein TPRDII, complete eds 339 5520 10644 1,3 2.OOE-76 D84295.1 NT Human mRNA for possible protein TPRDII, complete cds 339 5520 10645 1.3 2.OOE-76 D84295.1 NT Human mRNA for possible protein T12RDII, complete ods 453 5619 0.7 2.OOE-76 4557662 NT Homo sapiens Immunoglobulin (CD7UA binding protein 1 (1 13P1) mRNA 575 5735 10852 1.1 2.OOE-76 4503944 NT Homo saplens glucagon (GCG) mRNA 1014 6154 11310 1.0 2.OOE-76 4758053 NT Homo sapiens cAMP responsive element binding protein 1 (CREB1) mRNA 1518 6645 11813 0.6 2.OOE-76 4504028 NT Homo sapiens GM2 ganglioside activator protein (GIVI2A) mRNA 1518 6645 11814 0.6 2.OOE-76 4504028 NT Homo, sapiens GM2 ganglioside activator protein (GIVI2A) mRNA 1886 7004 12190 0.5 2.OOE-76 AA253954.1 EST-HUMAN zs60111 I.sl Stratagene schizo brain S1 1 Homo saplens cDNA done IMAGE:701925 3' 2811 7962 13068 2.8 2.OOE-76 P23266 SWISSPROT OLFACTORY RECEPTOR-LIKE PROTEIN F5 3257 8404 13511 2.0 2.0012-76 AA445992.1 EST-HUMAN zw64a02.sl SoarestesdúLNHT Homo saplens cDNA done IMAGE:780986 Ysimilar to SW:1TP-5-HUMAN P18084 INTEGRIN BETA-5 SUBUNIT PRECURSOR.; 3257 8404 13512 2.0 2.OOE-76 AA445992.1 EST-HUMAN zw64e02.sl SoarestestiELNI-IT Homo sapiens cDNA clone IMAGE:780986 Ysimilar to SW:1TI35-HUMAN P18084 INTEGRIN BETA-5 SUBUNIT PRECURSOR.; 4043 5467 10597 0.9 2.OOE-76 D84295,1 NT Human mRNA for possible protein TPRDII, complete cds 4600 9714 14806 4.5 2.0012-76 4758981 NT Homo saplens pepdde YY (PYY) mRNA 4867 9974 15059 6.3 2.OOE-76 AW879618.1 EST-HUMAN QV3-OT0028-220300-132- bl 1 OT0028 Homo sapiens eDNA 5068 10166 15242 1.3 2.OOE-76 503 1660 NT Homo sapiens EGF-like repeats and discoldin i-like domains 3 (EDIL3), mRNA 4200 9326 14413 2.2 1.0OE-76 D63874.1 NT Human mRNA for HIVIG-11, complete cds 4200 9326 14414 2.2 1.0012-76 D63874.1 NT Human mRNA for HIV[GA, complete cds 715, 5869 11007 0.9 7.OOE-77 AW370405.1 EST-HUMAN RC2-13T0256-2411 099-01 '1402 BT0256 Homo sapiens cDNA 1887 7005 12191 1.2 7.0012-77 AA625755.1 EST-HUMAN zu91g01.sl Soare tesds NHT Homo saplens cDNA clone IMAGE:745392 3' 2360 7462 12668 0.8 7.OOE-77 4505944 NT Horno sapiens polymerase (RNA) 11 (DNA directed) polypepfide E (25kD) (POLR2E) mRNA 2360 74 2 12669 0.8 7.OOE-77 4505W NT Homo sapiens polymerase (RNA) 11 (DNA directed) polypeptide E (25kD) (POLR2E) mRNA 262 5449 10575 1.5 6.OOE-77 4504600 NT Homo saplens Interferon (alpha, beta and omega) receptor 2 (IFNAR2) mRNA 1125 6262 11414 0.9 6.OOE-77 AW957753.1 EST-HUMAN EST369823 MAGE resequences, MAGE Homo, sapiens cDNA 1524 6651 11819 17.6 6.OOE-77 A1204066.1 EST HUMAN qe77h12.xl Soares--- fetaUung_. Nbi-11-19W Homo sapiens d3NA clone IMAGE:1745063 3, 1216 6346 11505 0.6 5.OOE-77 AF041015.1 NT 7 Homo sapiens gluwkinase (GCK) gene, exon 2 1337 6465 11633 1.2 5.OOE-77 4557250 NT Horno saplens disintegrin and metalloprotease domain 10 (ADAM10) mRNA 2736 7820 13024 1,0 5.OOE-77 4503160 NT Homo sapiens cullin 1 (CUL1) mRNA 4605 9719 14812 2.0 5.OOE-77 5031660 NT Homo saplens EGF-like repeats and discoldin Wilke domains 3 (EDIL3), mRNA 4605 9719 14813 2.0 5.OOE-77 5031660 NT Homo, sapiens EGF-like repeats and discoidin 1-like domains 3 (EDIL3), mRNA 4853 9960 15046 2.1 5.OOE-77 AL043953.1 EST-HUMAN DOZp434G1172Q_rl 434 (synonym: htes3) Homo, sapiens cDNA done DKFZp434G1728 5, 1859 6977 12162 0.7 4.OOE-77 7706762 NT Homo sapJens viilJn-like (VILL), mRNA 1929 7046 12237 1.1 3.OOE-77 5730038 NT Homo saplens SET domain and madner transposase fusion gene (SETMAR) mRNA 7046 12238 1.1 3.OOE-77 5730038 NT Homo saplens SET domain and mariner transposase fusion gene (SETMAR) mRNA (Yr Page 129 of 196 Table 4

Page 130 of 196 3214 8362 13473 6.9 3.OOE-77 A1963236.1 EST-HUMAN wt29c03.xl NCI CGAP_Utl Homo saplens cDNA done IMAGE:2508868 3' similar to g15:1K00558 TUBULIN ALPHA-1 CHAIN (HUMAN); 1414 6542 11717 0,6 2.OOE-77 AW997712.1 F-ST HUMAN RC3-BN0053.17020"1 11- h01 BN0053 Homo saplens cDNA 2044 7157 12362 0.8 2.OOE.77- L41825.1 NT Homo sapt CYP17 gene, Send 2056 7168 12374 1.0 2.OOE-77 7706315 NT Homo sapiens CGI-79 protein (LOC51634), mRNA 2549 7946 12844 0.7 2.OOE-77 AB037836.11 NT Homo sapiens mRNA for KIAA1415 protein, partial cds 2549 7946 12845 0,7 2.OOE-77 A13037836.11 NT Homo sapiens mRNA for KIAA1415 protein, partial cds 3305 8450 13560 0.9 2.0012-77 AF016191.1 NT Rattus norvegicus potassium channel (erg3) mRNA, complete cds 3305 8450 13561 0.9 2.OOE-77 AF016191.1 NT Rattus norvegicus potassium channel (er93) mRNA, complete cds 3947 9080 14161 1.3 2.OOE-77 BE044316.1. EST HUMAN ho43b05.xl Soares NFGBC_Sl Homo sapiens cDNA done IMAGE:3040113 3'similar to SW:GAG2 HUMAN P10264 RETROVIRUS-RELATED GAG POLYPROTEIN; 4315 9438 14527 0.9 2.OOE-77 A1613519.1 EST HUMAN tw22g02.xl NCI_WAP-Bm52 Homo sapiens cDNA done IMAGE:2260466 Ysimilar to TR:065245 065245 F21E10.7 PROTEIN.; 4315 9438 14528 0.9 2.OOE-77 A1613519.11 EST HUMAN tw22g02.xl NCLWAP_IE1m52 Horno saplens c1DNA done JMAGE:2260466 Ysimilar to TR:065245 065245 F21E10.7 PROTEIN.; 4492 9612 3.5 2.OOE-77 4504068 NT Homo sapiens glutamic-oxaloacefic transaminase 2, mitochondrial (aspartate aminotransferase 2) (GOT2), nuclear gene encoding mitochondrial protein, mRNA 4659 9771 14866 3.6 2.OOE-77 AA653025.11 EST HUMAN ns68g12.sl NCl-WAP-Pr2 Homo saplens cDNA done IMAGE:1 188838 similar to SW:R1-29 HUMAN P47914 60S RIBOSOMAL PROTEIN L29. [11;contains element MSR1 repetitiveilement; 37 5246 10353 1.0 1.OOE-77 AB033102.1 NT Homo saplens mRNA for KIAA1276 protein, partial ods 37 5246 10354 1.0 1.OOE-77 A13033102.1 NT Horno saplens mRNA for KIAA1276 protein, partial cds 271 5459 10586 0.6 1.OOE-77 4502166 NT Homo sapiens arnyloid beta (A4) precursor protein (protease nexin-11. Alzheimer disease) (APP), mRNA 271 5459 10587 0.6 1.OOE-77 4502166 NT Homo saplens arnyloid beta (A4) precursor protein (protease nexin-I I. Alzheimer disease) (APP), mRNA 857 7901 11167 17 1.OOE-77 4502166 NT Homo sapiens amytold beta (A4) precursor protein (protease nexin-1 1,.6jzheimer disease) 857 7901 11168 1.7 11.0OE-77 4502166 NT (APP), mRNA Homo saplens arnylold beta (A4) precursor protein (protease nexin-11, Ajzheimer disease) (APP), mIRNA 2394 7494 12700 1.2 11.0OE-77 AB029024.11 NT Homo saplens mRNA for K1AA11 101 protein, complete cds 3007 8159 13259 2.8 11.0OE-77 4503300 NT Homo sapiens 2,4-diengyl CoA reductase 1, mitochonddal (DECR1), mRNA 4256 9381 14462 3.0 11.0OE-77 7706299 NT Homo saplens CGI-60 protein (LOC51626), mRNA 4423 9543 14635 14.7 11.0OE-77 AJ229041.1 NT Homo sapiens 959 kb condg between AM1.11 and CBR1 on chromosome 21q22; segment 113 4552 9671 14761 2.0 1.OOE-77 6552322 NT Homo sapiens breast cancer 1, early onset (BRCAI), transcript variant BRCAl-exon4, mRNA 5179 10271 15342 2.9 1.OOE-77 AW755254.1 EST HUMAN CMYA5 Human cardiac muscle expression library Homo saplens cDNA clone 4151935 similar to CIVIYAS Cardlomyopathy associated gene 5 2515 7 2813 1.5 5.0012-78 AW673424.1 EST-HUMAN ba54h03.yZI N1H - MGC - 10 Homo saplens cIDNA clone IMAGE:2900405 5'simiiar to WPM8B6A.6 CE22121; Table 4

Page 131 of 196 3339 8483 13598 3.8 5.OOE-78 M55586.1 NT Human collagenase type IV (CLG4) gene, exon 6 4610 9724 14819 1.4 5.OOE-78 AB002348.2 NT Horno sapiens mRNA for KIAA0350 protein, partial cds 1502 6628 11797 0.6 4.OOE-78 A1.355841.1 NT Novel human gene mapping to chomosome 22 1629 6755 11925 0.6 4.OOE-78 A1985094.1 EST HUMAN wr97b12.xl NCI- CGAF_KJdl 1 Homo sapiens cDNA done IMAGE:2495615 Ysimilar to SW:WAP_PIG 046655 WHEY ACIDIC PROTEIN PRECURSOR; 2270 7376 12585 0.8 4.OOE-78 AF107405.1 NT Homo saplens pre-mRNA splicing factor (SFRS3),mRNA, complete ods 4227 9351 14431 1.4 4.OOE-78 7656876 NT Homo sapiens syncydn (LOC30816); mRNA 4664 9776 14872 1,3 4.OOE-78 4505806 NT Homc, sapiens phosphaddylinositol 4-kinase, catalytic, alpha polypepfide (PIMCA) mRNA 4664 9776 14873 1.3 4.OOE-78 4505806 NT Homo sapiens phosphatidylinositol 4-kinase, catalytic, alpha polypeptide (PIMCA) mRNA 5351 10476 0.6 3.OOE-78 AF095901.1 NT Homo sapiens eRF1 gene, complete cds 5351 10477 0,6 3.OOE-78 AF095901.1 NT Homo sapiens eRF1 gene, complete cds 3178 8327 13440 0.9 3.OOE-78 4507164 NT Homo sapiens nuclear antigen Sp100 (SP100) mRNA 4015 8882 13971 0.9 3.OOE-78 4507334 NT Homo sapiens synaptojanin 1 (SYNJ1), mRNA 3083 8234 2.2 2.OOE-78 U04489.1 NT Homo sapiens type IV collagen alpha 5 chain (COL4A5) gene, exon 20 3932 9066 1.7 2.OOE-78 AA311872.1 ESTHUMAN EST182583 Jurkat T-cells V1 Homo sapiens cDNA V end 1860 6978 12163 1.8 9.OOE-79 AA601246.1 EST-HUMAN nol4gO9.sl NCII CGAF_Phel Homo sapiens cDNA done IMAGE:1 100704 Ysimilar to TR5239140 E239140 SPALT PROTEIN; 4758 9869 14963 2.5 9.OOE-79 BE000837.1 EST-HUMAN RC2-BN0074-090300-014- c12 BN0074 Horno sapiens cDNA 3682 8821 13914 1.2 8.OOE-79 AL163210,2 NT Homo sapiens chromosome 21 segment HS21C010 4391 9513 14601 0.9 8.OOE-79 D28476.1 NT Human mRNA for KIAA0045 gene. complete cds 4391 9513 14602 0.9 8.OOE-79 D28476.1 NT Human mRNA for KIAA0045 gene, complete ods 4805 9915 15007 1.7 8.OOE-79 AF083655.1 NT Homo sapiens procollagen Cproteinase enhancer protein (PCOLCE) gene, 5' flanking region and complete cels 4805 9915 15008 1.7 8.0OE-79 AF083655.1 NT Homo sapiens procollagen C- proteinase enhancer protein (PCOLCE) gene, 5'flanking region and complete cds 3139 8288 1.1 4.OOE-79 8922325 NT Horno sapiens hypothetical protein FLJ 10283 (FLJ 10283). mRNA 310 5494 10623 1.4 3.OOE-79 AF1 14488.1 NT Homo sapiens intersectin short isoform (ITSN) mRNA, complete ods 962 6107 11265 0.9 3.OOE-79 AF232708.1 NT Homo sapiens cell-line tsA201 a chlorlde.lon current Inducer protein I(Cin) gene, complete cds 3060 8211 13310 1.4 3.OOE-79 U09410.1 NT Human 7Jnc finger protein ZNF131 mRNA, partial cds 3727 8 F-4 13957 2.8 3.OOE-79 BE265169.1 EST HUMAN 601192921F1 N11- 1_1VIGCJ Homo sapiens cDNA done IMAGE:3536740 5' 4818 9927 5.0 3.OOE-79 AF116627.1 NT Homo sapiens PRO1 181 mRNA, complete cds 618 5777 10899 1.1 2.OOE-79 BE379926.1 EST-HUMAN- 60115941 5F2 NIM_MGC_53 Horno sapiens cDNA done IMAGE:3511107 5, 912 6058 11217 1.1 2.OOE-79 4757841 NT Horno sapiens BCL2-like 2 (BCL2L2) mRNA 1019 6159 1.4 2.OOE-79 A1523747.1 EST-HUMAN th18h07.xl NCI CGAP Pr28 Homo saplens cDNA clone IMAGE:2118685 3' 2101 7212 12420 5.1 2.0012-79 4585863 NT Homp saplens phosphodlesterase 6A, cGMP-specific, rod, alpha (PDE6A), mRNA 2101 7212 12421 5.1 2.OOE-79 4585863 NT Horno sapiens phosphodlesterase BA, cGMP-specific, rod, alpha (PDE6A), mRNA 2146 7256 12463 1.0 2.0012-79 AJ271408.1 NT - Homo sapiens mRNA for Fas- assodated factor, FAF1 (Fafl gene) Table 4

2265 7371 12581 0.6 2.OOE-79 AF244138.1 NT Homo sapiens hepatocellular cardnoma-associated antigen 88 (HCA88) mRNA, complete cds 3838 8974 14074 0.9 2.OOE-79 AF170492.1 NT Homo saplens chloride channel CLC4 (C1C4) mRNA, complete cdS 4074 9201 14287 1.2 2.OOE-79 AJ271408.1 NT Homo sapiens mRNA for Fas- associated factor, FAF1 (Fafl gene) 4590 9704 14797 1,0 2.OOE-79 AL1 63206.2 NT Homo sapien_s chromosome 21 segment HS21 C006 204 5397 10525 1.5 1.OOE-79 BE252804.1 EST-HUMAN 601112953F1 Nib_1VIGC 1 g Homo sapiens cIDNA done IMAGE:3353581 5, 3107 8257 13360 3.8 9.OOE-80 AA725848.1 EST_HUMAN a123e05.sl Soares testis NHT Homo sapiens cDNA clone 1343648 X 3107 8257 13361 3.8 9.OOE-80 AA725848.1 EST-HUMAN a123e05.sI Soares. testis NHT Homo saplens cDNA clone 1343648 3' 3551 8691. 1.0 8.OOE-80 U94387.1 NT Homo saplens Y chromosome spermatogenesis candidate protein (RBM) pseudogene mRNA, partial cds 882 6030 11189 0.8 6.OOE-80 A1422197.1 EST-HUMAN tf58d02.xl Wi_pGAP Bm23 Homo sapiens cIDNA clone IMAGE:2103459 Ysimilar to SW:NUEM HUMAN j16795 NADH-UBIQUINONE OXIDOREDUCTASE 39 KID SUBUNIT PRECURSOR; 1624 6750 11918 0.7 6.OOE-80 U64898.1 NT Homo saplens NRD convertase mRNA, complete cds 4188 9314 14397 1.1 6.OOE-80 AB032981.1 NT Homo sapiens mRNA for K1AA11 155 protein, partial eds 4188 9314 14398 1.1 6.OOE-80 AS032981.1 NT Homo saplens mRNA for K1AA1 155 protein, partial cds 573 1 10851 1.1 5.OOE-80 4506228 NT Homo sapiens proteasome (prosorne, macropain) 26S subunit, non-ATPase, 3 (PSIVID3) 5733 mRNA 817 967 11124 1,3 5.OOE-80 AF108830.1 NT Homo sapiens sedne-threonine protein kinase (MNBH) mRNA, complete cds 817 5967 111251.3 5.OOE-80 AF108830.1 NT Homo sapiens sedne-threonine protein kinase (MNBH) mRNA, complete cds 1172 6306 4.8 5.OOE-80 X91647.1 NT H.sapiens ncxl gene (exon 12) 1440 6567 0.8 5.OOE-80 ALI 63283.2 NT Homo sapiens chromosome 21 segment HS21 C083 2311 7414 12623 0.9 5.OOE-80 U89358.1 NT Human 1(3)mbt protein homolog mRNA, complete ods 2380 7482 12684 1.4 5.OOE-80 AB037855.5 NT Homo saffiens mRNA for KIAA1434 protein, partial ods 2764 7848 13050 1.1 5.OOE-80 4504292 NT Homo sapiens H3 histone family, member J (H3FJ) mRNA 3953 9086 14168 1.1 5.OOE-80 AB019038.1 NT Homo sapiens HMT-1 mRNA for beta-11,4 mannosyttransferase, complete cds 3953 9086 14169 1.1 5.OOE-80 AB019038.1 NT Horno, sapiens HMT-1 mRNA for beta-1,4 mannosyttransferase, complete cds 4872 9979 15063 1.7 5.OOE-80 AL1 63268.2 NT Homo sapiens chromosome 21 segment HS21 C068 210 5403 1.6 3.OOE-80 AL1 63210.2 NT Homo saplens chromosome 21 segment HS21C010 1308 7912 11604 1.8 2.OOE-80 AA215796.1 ESTHUMAN zr98d04xl NCI_PGAF GC131 Homo sapiens cDNA done IMAGE:683719 5' 1308 7912 11605 1.8 2.OOE-80 AA215796.1 EST-HUMAN zr98d04.rl NCI CGAP GCBI Homo sapiens cIDNA done IMAGE:683719 5' 1757 6878 12059 2.3 2.OOE-80 R35321.1 EST HUMAN Y05a08xl Soares Infant brain 1 NIB Homo sapiens cIDNA done IMAGE:38060 5' 1816 6935 12125 0.7 2.0OE-80 A821.1 EST HUMAN RET4B7 subtracted retina cIDNA library Homo sapiens cDNA clone RET4B7 2009 7123 12323 2.4 2.OOE-80 AL043116.2 EST HUMAN DKEp434D1 323-rl 434 (synonym: htes3) Homo sapiens cDNA done DKFZp434D1 323 5' 337 5518 0.6 1.OOE-80 AL1 63303.2 NT Homo saplens chromosome 21 segment HS21 Cl 03 782 5934 11083 1.1 1.OOE-80 AF231920.1 NT Homo saplens chromosome 21 unknown mRNA 1911 7028 1.1 1.OOE-80 A1732656.1 EST-HUMAN nnOlf12.x5 NCLWAP-Co9 Homo saplens cDNA done IMAGE:1076495 Ysimilar to contains OFR.tl OFR repetitive element; 3515 8656 13763 1.0 1.0015-80 8922391 NT Homo sapiens hypothetical protein FLJ10379 (FLJ10379), mRNA 4358 9480 14571 1.0 1.0012-80 AF077188.1 NT Horno saplens cullin 4A (CUL4A) mRNA, complete cds Page 132 of 196 Table 4

5192 10283 15351 1.0 1.OOE-80 AL163278.2 NT Homo saplens chromosome 21 segment HS21 C078 4290 9414 14503 4.8 6.oorz-ai BE256829.1 EST-HUMAN 601111970F1 NIH MGC 16 Homo sapiens cDNA done IMAGE:3352840 5, 4290 9414 14504 4.8 6.OOE-81 BE256829.1 EST-HUMAN 601111970F1 NI!j. 10GQ_16 Homo sapiens cONA clone IMAGE:3352840 V 2170 7279 12492 1,1 5.OOE-81 BE268042.1 ES-_HUMAN 601125505F1 N1H MGC 8 Homo sapiens cDNA done IMAGE:3345480 5' 1779 6900 12088 1.0 4.OOE-81 AW779612.1 EST_HUMAN hn9M02.xl NCI_QGAP_Col4 Homo sapiens cIDNA dons IMAGE:3035907 Ysimilar to SW:COPGLBOVIN P53620 COATOMER GAMMA SUBUNIT; 2058 7170 12377 2.1 4.OOE-81 8923056 NT Homo sapiens heUcal protein FU20048 (FLJ20048), mRNA 2058 7170 12378 2.1 4.OOE-81 8923056 NT Homo saplens hypothetical protein FLJ20048 (F1,120048), mRNA 3134 8283 13390 3,8 4.0RE-81 A13037766.1 NT Homo sapleins mRNA for K1AA1 345 protein. partial cds 3576 8715 13812 1.2 4.OOE-81 AW004608.1 EST-HUMAN ws9OhO3.xl NCI_PGAP-Co3 Homo saplens eDNA done IMAGE:2505269 3'simiiar to TR:043815 043815 STRIATIN.

1246 6375 11532 3,2 3.OOE-81 Y18000.1 NT Homo sapiens NF2 gene 1246 6375 11533 3,2 3.OOE-81 Y18000.1 NT Homo, saplens NF2 gene 2320 7423 12632 0,6 3.OOE-81 AF077188.1 NT Homo saplens cullin 4A (CUL4A) mRNA, complete cds 2961 8112 13217 5.1 3.OOE-81 4506280 NT Homosaplens plelotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) (PTN) mRNA 2961 8112 13218 5.1 3.OOE-81 4506280 NT Homo sapiens ptelotrophin (hepadn binding growth factor 8, neurite growth-promoting factor 1) (PTN) mRNA 4933 10039 0.9 3.OOE-81 AL163283.2 NT Homo sapiens chromosome 21 segment HS21 C083 3707 8845 13936 1.0 2,0012-81 AW611542.1 EST-HUMAN hg85c01.xl NCI_CGAF_Kidl 1 Homo sapiens cIDNA done IMAGE:2952384 3' 4579 9695 14788 0.9 2.OOE-81 5453871 NT Homo saplens platelet-derived growth factor receptor-like (PDGFRLI mRNA 1403 6530 11701 1.2 1.0OE-81 W26539.1 EST_HUMAN 33M Human retina cDNA randomly primed sublibrary Homo sapiens cIDNA 2144 7254 12462 0.9 1.0OE-81 N66951.1 EST - HUMAN za48112.sl Scares fetal liver spleen INFLS Homo sapiens cDNA done IMAGE:295823 3' 3662 8741 13836 2.0 1.OOE-81 AW960658.1 ESTHUMAN EST372729 MAGE resequences, MAGF Homo sapiens cDNA 4414 9534 14623 3.1 1.0OE-81 AA040370.1 ESTHUMAN zk45h09xl Soares_pregnant uteru!_NbHPU Homo saplens c1DNA done IMAGE:485825 V similar to PIR:S52437 S524377 CDPAlacyIglycerol synthase fruit fly; 4546 9665 14754 7.9 1.OOE-81 BE047996.1 ESTHUMAN tz45c04.yl NCLC_Pm52 Homo saplens cDNA done IMAGE:2291526 S' 12 5220 10321 0.6 8.OOE-82 AF161406.1 NT Homo saplens HSPC288 mRNA, parfial ods 101 5220 10321 1.3 8.OOE-82 AF161406.1 NT Homo sapiens HSPC288 mRNA, partial cds 263 5450 10576 0.6 8.OOE-82 U08988.1 NT Human CRFB4 gene. partial cds 797 5M 11098 0.7 8.OOE-82 U08988.1 NT Human CRF84 gene, partial cds 869 6017 11177 1.1 8.OOE-82 U08988.1 NT Human CRFB4 gene, partial ods 1475 6602 11776 1.1 8.OOE-82 A13037748.1 NT Homo sapiens mRNA for KIAA1327 protein, partial cds 1636 6762 11932 1.2 8.OOE-82 6715601 NT Homo sapiens glutathione peroxidase 5 (epididymal androgen-related protein) (GPX5), transcript variant 2, mRNA 4150 9276 14357 0.8 8.OOE-82 8923432 NT Horno saplens hypothetical protein FLJ20461 (FL.120461), mRNA 4034 9162 14245 0.8 5.OOE-82 AA515512.1 EST-HUMAN nf69el I.sl NCI, _PGAP_Co3 Homo saplens ciDNA clone IMAGE:925196 3' 1647 6773 11944 2.4 4.OOE-82 AF081484.1 NT Horno sapiens alpha-tubulin Isoform 1 mRNA, complete cds 4638 9752 14845 0.8 4.OOE-82 H17755.1 EST_HUMAN ym40e08xl Soares Infant brain 1 NIB Homo saplens cDNA done IMAGE:50499 V 97521 4638 14846 0.8 4.00 -82 H17755.1 EST-HUMAN ym40e08xl Soares infant brain 1NIB Homo sapiens cDNA done IMAGE:50499 5' 1^ r Page 133 of 196 Table 4

276 5464 10593 4.7 3.0012-82 4502166 NT Homo sapiens amyioid beta (A4) precursor protein (protease nexin-l I, Alzheimer disease) (APP), mRNA 687 5842 10978 0.8 3.0012-82 BE005705.1 EST HUMAN RC2-BN0120-010400-013- f02 BN0120 Homo sapiens cIDNA 703 5858 1.0 3.OOE-82 4502506 NT Homo saplens complement component 5 (C5) mIRNA 770 5922 11071 1.5 3.OOE-82 5174702 NT Homo sapiens transforming growth factor beta-activated kinase-binding protein 1 (TAB 1), mRNA 852 6001 11161 1.1 3.OOE-82 4502166 NT Homo sapiens amylold beta (A4) precursor protein (protease nexin-l I. Alzheirner disease) (APP), mRNA 1045 6185 4.7 3.OOE-82 AA725848.1 EST-HUMAN M23e05.sl Soares testis NW Homo saplens cDNA clone 1343648 3' 1333 6462 11630 5.5 3.OOE-82 AW875073.1 EST-HUMAN RC6-PT0001-190100-021BO2 PT0001 Homo saplens cIDNA 1450 6577 11751 0.7 3.OOE-82 AL163285.2 NT Homo sapiens chromosome 21 segment HS21 C085 1961 7077 12276 0.9 3.OOE-82 4501922 NT Homo saplens adenylate cyclase activating polypeptide 1 (pituitary) receptor type 1 (ADCYAPIR1) mRNA 3234 8382 2.1 3.OOE-82 5453811 NT Homo saplens neurotrophic tyrosine kinase, receptor, type 2 (NTIRK2) mRNA 4836 9944 15033 0.9 3.OOE-82 AA1 35979.1 EST-HUMAN zn93b04.rl Stratagene lung carcinoma 937218 Homo saplens cIDNA clone IMAGE:565711 5, similar to SW:PAGTBOVIN Q07537 POLYPEPTIDE N ACETYLGALACTOSAMINYLTRANSFERASE; 582 5742 10858 0.7 2.OOE-82 AB023216.1 NT Homo sapiens mRNA for KIAA0999 protein, partial cds 582 5742 10859 0.7 2.OOE-82 AB023216.1 NT Homo sapiens mRNA for KIAA0999 protein, partial cds 1660 6784 11960 0,6 2.OOE-82 AL046390.1 EST HUMAN DKFZp434M1 17-rl 434 (synonym: htes3) Homo saplens cDNA done DKFZp434M1 17 V 2176 7285 12496 1.1 2.OOE-82 5453855 NT Homo sapiens pericentriolar material 1 (PCMI) mRNA 3231 8379 1.8 2.OOE-82 6997248 NT ns sal (Drosophila)-like 1 (SALL1), mRNA 3772 8909 13998 1.1 2.0012-82 D87675.1 NT Homo saplens DNA for amylold precursor protein, complete cds 4140 9266 14347 1.1 2.OOE-82 450 4116 NT Homo sapiens glutamate receptor, lonotropic, kainate 1 (GRIK1) mRNA 4458 9578 14675 1,0 2.OOE-82 AB02901 9.1 NT Homo sapiens mRNA for KIAA1096 protein, partial cds 4458 9578 14676 1.0 2.OOE-82 AB029019.1 NT Homo saplens mRNA for K1AA1 096 protein, partial ods 4768 9879 14973 3.2 2.OOE-82 AF045555.1 NT Homo sapiens wbscri (WBSCR1) and wbscr5 (WBSCR5) genes, complete cds, alternatively spliced and replication factor C subunit 2 (RFC2) gene, complete cds 5013 10115 15185 1.7 2.0012-82 4507580 NT Homo sapiens tumor necrosis factor receptor superfamily, member 5 (TNFRSF5) mIRNA 5013 10115 15186 1.7 2.OOE-82 4507580 NT Homo sapiens tumor necrosis factor receptor superfamily, member 5 (TNIFIRSF5) mRNA 1264 6393 11552 0.7 1.0011-82 BE064386.1 EST-HUMAN RC4-BT0310-110300-015- flO BT0310 Homo saplens cDNA 1265 6394 11553 0.8 1.OOE-82 AB01 1110.2 NT Homo saplens mRNA for KIAA0538 protein, partial ods 1392 6519 11687 0.7 8.OOE-83 BE383973.1 EST HUMAN 601273346F1 N1H MGQ_20 Homo saplens cIDNA clone IMAGE:3614362 5, 1656 7869 11954 0.7 8.OOE-83 N66951.1 EST-HUMAN za48112.sl Soares fetal liver spleen WLS Homo saplens cIDNA done IMAGE:295823 3, 2836 7987 1.6 7.OOE-83 AA584655.1 ESTHUMAN nol2h0I.sl NCI_CGAP_Phol Horno sapiens cDNA done IMAGE:1 100497 3'similar to contains Alu repetitive element; 4864 9971 15055 8.7 7.OOE-83 N27808.1 EST HUMAN e09.rl Soares melanocyte 2NbHM Horno sapiens cIDNA clone IMAGE:265576 5' .1 Page 134 of 196 Table 4

397 5565 10701 1,3 6.OOE-83 M33320.1 NT Human platelet Glycoprotein lib (GPI1b) gene, exons 2-29 1747 6869 12047 0.5 6.OOE-83 AW573088.1 EST-HUMAN W31h03.xl Soares_NFL, _GBC - S1 Horno saplens cDNA done IMAGE:2933525 Ysimilar to SCYBEELHAIEIN P44471 HPOTHETICAL PROTEIN H10034.; 2984 8136 13241 1,1 6.OOE-83- AW816405.1 EST-HUMAN. QV4-ST0234-181199-037- f05 ST0234 Homo sapiens cIDNA 3031 8183 13283 0.9 6.OOE-83 AA701457.1 EST-HUMAN z159c05.sl Soares_fetal- liveLspicen-1 NFI.SS1 Homo saplens cONA done IMAGE:435080 3' 931 6078 1.4 5.0OE-83 U17883.1 NT Human succinate dehydrogenase iron-pro In subuffit (sdhB) gene, exon 5 2004 7871 0.8 5.OOE-83 AF006305.1 NT Homo sapiens 26S proteasome regulatory subunit (SUG2) mRNA, complete cds 3586 8725 13821 0.9 5.OOE-83 A1-133207.2 NT Novel human gene mapping to chomosome X 5011 10113 15183 11.0 5.OOE-83 4557013 NT Horno saplens catalase (CAT) mRNA 5011 10113 15184 11.0 5.OOE-83 4557013 NT Homo sapiens catalase (CAT) mRNA 5094 10192 15271 019 5.OOE-83 AF083827.1 NT Homo sapiens dihydropyddine receptor alpha 2 subunit (CACNA2D1) gene, exon 11 624 5783 10905 1.5 4.OOE-83 AF224669.1 NT Homo saplens mannosidase, beta A, lysosomal (MANBA) gene, and ubiquitin-conjugating enzyme E2D 3 (UBE2D3) genes, complete cds 981 6126 1.5 3.OOE-83 AA36831 1.1 EST-HUMAN EST79542 Placenta 1 Homo sapiens cDNA similar to similar to endogenous retrovirus ERV9 2750 7834 0.7 3.OOE-83 AA632654.1 EST HUMAN np87c07.si NCLMAPJhyll Homo saplens cDNA done IMAGE:1 133292 similar to contains THR.Q THR repetitive elemenC, 1759 6880 12061 0.7 2.OOE-83 AA993492.1 EST_HUMAN ot64g05.sl Soares_jtestis_NI-IT Homo sapiens cDNA done IMAGE:1621592 Ysimilar to TR:Q92614 Q92614 MYELOBLAST K1AA0216.; 1759 6880 12062 0.7 2.OOE-83 AA993492.1 EST_HUMAN ot64905.sl Soarei_tesfis_NHT Homo sapiens eDNA done IMAGE:1621592 3'sImilar to TR:Q92614 Q92614 MYELOBLAST KIAA021 6.; 1883 7001 12186 0.8 2.OOE-83 N66951.1 EST HUMAN za48fl 2M Soares fetal liver spleen 1 NFLS Homo sapiens cIDNA done IMAGE:295823 3, 1983 7098 12301 1,1 2.OOE-83 AW247459.1 EST-HUMAN 2819246.5prirneNIH MGC 7 Homo saplens d3NA done IMAGE:2819246 5' 3708 8846 1.0 2.OOE-83 A1.163202.2 NT Homo sapiens chromosome 21 segment HS21 C002 4241 9366 14447 4.5 2.0OE-83 AF202879.1 NT Homo saplens hematopoiefic progenitor wit antigen CD34 precursor (C1334) mRNA, partial cds 4553 9672 14762 8.1 2.OOE-83 7706398 NT Homo sapiens ankydn repeatcontaining protein AS13-2 (LOC51676), mRNA 4553 9672 14763 8.1 2.OOE-83 7706398 NT Homo sap)ens ankyrin repeat- containing protein AS13-2 (LOCS1 676), mRNA 1273 6402 11560 1.4 1.0OE-83 4W5492 NT Homo sa-plens oxoglutarate dehydrogenase (lipoamide) (OGDH) mRNA 1273 6402 11561 1.4 11.0OE-83 4505492 NT Homo saplens oxoglutarate dehydrogenase (lipoamide) -OGIDH) mRNA 1390 6517 11684 6.0 1.0OE-83 4504326 NT Homo saplens hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolaselenoyl-Coenzyme A hydratase (hifunctional protein), beta subunit (HADHB) mRNA 1390 6517 11685 6.0 1.0OE-83 4504326 NT Homo sapiens hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyi-Coenzyme A thiolaselenoyi-Coenzyme A hydratase (trifunctional protein), beta subunit (HADHB) mRNA 3146 8295 13404 0.8 1.OOE-83 7662349 NT Homo saplens cell recognition molecule Caspr2 (K1AA0868), mRNA 3793 8930 14023 3.6 1.0OE-83 AF053768.1 NT Rattus norvegicus brain specific cortactin-binding protein C9P90 mRNA, partial cds INT 4151 9277 14358 2.2 1.OOE-83 Z25822.1 sapiens gene for mitochondrial dodecenoy]-CoA delta-isomerase, exon 3 \,P Page 135 of 196 Table 4

Page 136 of 196 4789 9900 14993 1.4 1.OOE-83 45021 66 NT Homo sapiens arnylold beta (A4) precursor protein (protease nexin-li, Adheimer disease) (APP), mRNA 2348 7450 12657 1.7 6.OOE-84 AA776574.1 EST-HUMAN ac86a03.sl Stratagene schizo brain S1 1 Homo sapiens cDNA clone IMAGE:971020 3' 697 5852 10988 1.1 5.OOE-84 AA38281 1.1 EST HUMAN EST96094 Testis 1 Horno, saplens cDNA Wend 2981 8132 1.0 5.OOE-84 AF109718.1 NT Homo sapiens chromosome 3 subtelomedo region 1354 6482 11648 1.1 4.OOE-84 A13037735.1 NT Homo sapiens mRNA forRIAA1314 protein, partial ods 1389 6516 11683.1.5 4.OOE-84 A1685321.1 EST-HUMAN wa76c04.xl Soare_NFL, _GBC_Sl Homo sapiens cDNA done IMAGE:2302086 Ysimilar to SW:WDQ_HUMAN 043847 NARDILY.SIN PRECURSOR; 4869 9976 15061 1.8 4.OOE-84 AF069601.2 NT Homo sapiens myosin light chain kinase lsoforrn 2 (MI-CK) mRNA, complete cds 5060 10158 15233 1,3 4.OOE-84 U94982.1 NT Human 2,4-dienoyl-CoA reductase gene, exons 3 and 4 313 5497 10626 1.4 3.OOE-84 AF026200.1 NT Homo saplens Bachl protein homolog mRNA, partial cds 1137 6273 11423 0.9 3.OOE-84 4758081 NT Homo sapiens chondroldn sulfate prote2giy"n 2 (versican) (CSPG2) mRNA 1917 7034 12222 1.2 3.OOE-84 5453855 NT Homo sapiens pericentriolar material 1 (PCM1) mRNA 1962 7078 12277 1,1 3.OOE-84 AL096880.1 NT Novel human mRNA containing Zinc finger C2H2 type domains 3542 8683 13783 1.2 3.OOE-84 A13026898.1 NT Homo sapiens DNA, DLEC1 to ORCTL4 gene region, section 112 (DLEC1, ORCTI-3, ORCTL4 genes, complete ods) 3689 8827 13921 4.1 3.OOE-84 AF014459.1 NT Homo sapiens X-linked juvenile rednoschisis precursor protein (Xl-RS1) mRNA, complete cds 2913 8064 13172 9.6 2.OOE-84 AF036943.1 NT Homo sapiens myelin transcription factor 1-like (MYT14) mRNA, complete cds 2932 8083 13191 0.9 2.OOE-84 X8921 1.1 NT H.sapiens DNA for endogenous retroviral like element 309 5493 10622 0.5 1.0OE-84 AF1 14488.1 NT Homo sapiens Intersectin short lsoform (ITSN) mRNA, complete cds 537 5700 10822 1.8 1.OOE-84 4507952 NT Homo sapiens tyrosine 3monooxygenaseltryptophan 5-monooxygenase activation protein, zeta polypeptide (YWHAZ) mRNA 1271 6400 1158 0.7 1.0OE-84 AA984379.1 EST HUMAN am85bl 1.sl Stratagene schizo brain.Sl 1 Homo sapiens cDNA done IMAGE:1 629885 3 2008 7122 12322 1.1 1.0012-84 BE392137.1 EST HUMAN 601308006F1 N111_1VIGQ_44 Homo saplens cDNA clone IMAGE:3626257 5' 3691 8830 13923 2.1 1.OOE-84 AA720851.1 EST HUMAN nw12e06.sl NCI CGAP SS1 Homo sapiens cDNA clone IMAGE:1239106 3' 4319 9442 14530 5.6 1.OOE-84 AJ229041.1 NT Homo sapiens 959 kb contiq between AML1 and CBRI on chromosome 21 q22; segment 113 4601 9715 14807 3.8 1.OOE-84 AL043314.2 ESTHUMAN DKFZ034N0323.0 434 (synonym: htes3) Homo saplens cDNA clone DKFZp434NO323 5' 4601 9715 14808 3.8 1.OOE-84 AL043314.2 EST HUMAN DKFZp434N0323j1 434 (synonym: htes3) Homo sapiens cDNA clone DKFZp434NO323 5' 4823 9442 14530 4.3 1.0012-84 AJ229041.1 NT Homo sapiens 959 kb condg between AML1 and CBR1 on chromosome 21q22; segment 113 951 6097 1.2 9.OOE-85 AL163209.2 NT Homo sapiens chromosome 21 segment HS21 C009 1057 6196 11348 08 9.OOE-85 U51432.1 NT Homo saplens nuclear protein Skip mRNA, complete cds 1057 6196 11349 0.8 9.OOE-85 U61432.11 NT Homo saplens nuclear protein Skip mRNA. complete cds 6687 11854 1.1 9.OOE-85 M33282.1 NT Human plasminogen gene, exon 7 6687 11855 1,1 9.OOE-85 M33282.1 NT Human plasminogen gene, exon 7 6776 11949 1.8 9.OOE-85 7657020 NT Homo saplens WFZp434P2111 protein (13KFZP434P21 1), mRNA Table 4

4158 9284 14364 0.9 -9.OOE-85 AL163280.2 NT Homa saplens chromosome 21 segment HS21 C080 4778 9888 14981 1.1 9.0OE-85 5901979 NT Homo sapiens heat shock transcription factor 2 binding protein (HSF2BP), mRNA 4825 9933 15023 1.0 9.OOE-85 AL163268.2 NT Homo saions chromosome 21 segment HS21 C068 1120 6257 11409 1.1 7.OOE-85 L05094.1 NT Homo saplens rfbosomal protein L27 mRNA, complete cds 2285 7390 12598 1.2 5.OOE-85 AL163284.2 NT Homo saplens chromosome 21 segment HS21 C084 2530 7626 12827 1,1 5.OOE-85 F08331.1 EST HUMAN HSCZQH081 normalized Infant brain cDNA Homo sapiens cDNA clone c-zqhO8 2530 7626 12828 1.1 5.OOE-85 F08331.1 EST HUMAN HSCZQH081 normalized infant brain cDNA Homo saplens cIDNA done c-zqhO8 1277 6407 11567 1.2 3.OOE-85 AF096157.1 NT Horno sapiens protein phosphatase 2A BR gamma subunit gene, exon 6 1741 6864 12041 1.2 3.OOE-85 T97495.1 EST HUMAN ye53909.rl Soares fetal liver spleen 1NFI.S Homo saplens cIDNA clone IMAGE: 121504 5' 4219 9343 14426 0.9 3.OOE-85 SE267189.1 EST-HUMAN 601189704F2 NIH MGC 7 Homo saplons cDNA done IMAGE:3533616 5' 4883 9991 15072 0.9 3.OOE-85 7363442 NT Homo sapiens olfactory receptor, family 12, subfamily D, member 2 (OR12D2), mIRNA 947 6093 11251 0.9 2.OOE-85 7657266 NT Homo saplens KIAA0929 protein Msx2 Interacting nuclear target (MINT) homolog (K1AA0929), mIRNA 1024 6164 11318 0,6 2.OOE-85 AF248540.1 NT Homo sapiens intersectin 2 (SH3D1 B) mRNA, complete cds 1400 6527 11696 2,6 2.0OE-85 5174775 NT Homo saplens apolipoprotein C-0 (APOC2) mRNA 1400 6527 11697 2.6 2.OOE-85 5174775 NT Homo sapiens apolipoproteln C-11 (APOC2) mRNA 2183 7292 12504 0,8 2.OOE-85 U10525.1 NT Human DNA polymerase beta gene, exons 12 and 13 2793 6444 1.4 2.OOE-85 7657468 NT Homo saplens similar to rat integral membrane glycoprotein POM121 (POM121 Ll), MIRNA 4239 9364 14445 5.4 2.OOE-85 4505880 NT Homo saplens plasminogen (PLG) mRNA 4822 9931 15021 1.3 2.0012-85 AL163284.2 NT Homo saplens chromosome 21 segment HS21 C084 2241 7347 0.9 1.OOE-85 BE277489.1 EST-HUMAN 601179190F1 Nih_1v1G2.20 Homo sapiens cIDNA done IMAGE:3546959 5, 1410 6537 2.8 9.OOE-86 BE274217.1 EST-HUMAN 601120778F1 N1H MGC 20 Homo saplens cIDNA done IMAGE:2967690 5' 220 5412 10533 1,3 7.OOE-86 7662247 NT Homo saplens KIAA0680 gene product (K1AA0680), mRNA 921 6067 11223 1.3 7.OOE-86 AA860801.1. EST HUMAN a]88f08.si Soares_pamthyrolc!_tumo_NbHPA Horno saplens cDNA clone IMAGE:1403559 X 921 6067 11224 1.3 7.OOE.:86 AA860801.1 EST_HUMAN aj88fO8.sl Soares_parathyroldjumor NbHPA Homo sapiens cDNA done IMAGE:1403559 3' 1272 6401 11559 3.2 6.0OE-86 4505492 NT Homo sapiens oxoglutarate dehydrogenase (lipoamide) (OGDH) mRNA 4380 9502 3.2 6.OOE-86 8923209 NT Homo saplens hypothetical protein FU20220 {FU20220), mRNA 266 W3 10578 1.3 2.OOE-86 AA306264.1 EST-HUMAN EST1 77232 Jurkat T-cells V1 Horno saplens d3NA Cend 408 5576 0.6 2.OOE-86 AL163203.2 NT Homo sapiens chromosome 21 segment HS21C003 1173 6307 11461 0.7 2.OOE-86 N58977.1 EST-HUM AN yzl9aO8.rl Soares_mulfiple_sderosi_2NbHMSP Homo sapiens cONA done IMAGE:283478 5' 2222 7329 12543 1,1 2.OOE-86 A13033103.1 NT Homo sapiens mRNA for KIAA1277 protein, partial ods 3369 8512 13619 1.4 2.OOE-86 AW966142.1 ES-_HUMAN EST378215 MAGE resequences, MAGI Homo saplens cIDNA 3686 8824 13917 2,2 2.OOE-86 AF156776.1 NT orno sap ens ysophosphaddic add acyltransferase-delta (LPAAT-delta) mRNA, complete cds 3686 8824 13918 2.2 2.OOE-86 AF156776.1 NT Homo sapiens lysophosphaddic acid acyltransferase-delta (LPAAT-delta) mRNA, complete cds r- j Page 137 of 196 Table 4

3954 9087 2.4 2.OOE-86 AW515742.1 EST HUMAN hd87908.xl NCI CGAP GC6 Homo sapiens cDNA cAone IMAGE:2916542 3' 4679 9791 14892 2.8 2.OOE-86 AF056490.1 NT Homo saplens cAMP-specific hosphodiesterase 8A (PDE8A) mRNA, partial cds 1579 6705 11875 1.1 1.OOE-86 4826855 NT Homo saplens NADH dehydrogenase (ubiquinone) Fe-S protein 1 (75kD) (NADH-coanzyme 0 reductase) (NDUFS1) mRNA 3125 8274 13379 2.1 1.OOE-86 5453649 NT Homo saplens fibulin 5 (FBI.N5) mRNA 3197 8346 13459 2.4 1.OOE-86 L20492.1 NT Human gamma-glutamyl transpeptidase mRNA, complete cds 3256 8403 13509 1.3 1.OOE-86 AL163209.2 NT Homo saplens chromosome 21 segment HS21C009 3256 8403 13510 1.3 1.0OE-86 AL163209.2 NT Homo saplens chromosome 21 segment HS21 C009 3864 9000 14loo 11.5 1.OOE-86 7706161 NT Homo sapiens hypothetical protein (LOC51318), mRNA 3864 9000 14101 11.5 1.OOE-86 7706161 NT Horno sapiens hypothedcal protein (LOC51318), mRNA 4167 9293 14374 5.8 1.OOE-86 A1.163300.2 NT Homo saplens chromosome 21 segment HS21 Cl 00 1AA382811.1 4832 9940 15029 1.1 1.0OE-86 AF100751.1 NT Homo saPiens FK506-binding protein FK1323.1soform mRNA, complete cds 471 5636 10765 4.8 8.OOE-87 X62245.1 NT O.cuniculus mRNA for elongation factor 1 alpha 3482 8623 13735 0.9 6.OOE-87 7657213 NT Horno sapiens hormonally upregulated neu tumor-associated kinase (HUNK), mRNA 1142 6278 11430 0.6 5.0012-87 EST HUMAN EST96094 Testis 1 Homo sapiens cDNA Wend 950 6096 11253 1.3 4.OOE-87 AL163210.2 NT Homo saplens chromosome 21 segment HS21 C01 0 1155 6290 11444 3,6 4.OOE-87 AB037835.1 NT Horno sapiens mRNA for KIAA1414 protein, partial cds 1411 6538 11711 0.9 4.OOE-87 R78133.1 EST HUMAN y180f1O.rl Soares placenta Nb2HP Homo sapiens cDNA clone IMAGE:145579 5'simiiar to contains Su repetitive element; 1985 7100 12303 0.9 4.OOE-87 AB007925.1 NT Homo sapiens mRNA for KIAA0456 protein, partial cds 2372 7474 12674 1.1 4.OOE-87 7706299 NT Homo saplens CGI-60 protein (LOC51626), mRNA 2372 7474 12675 1.1 4.OOE-87 7706299 NT Homo sapiens CGI-60.protein (LOC51626), mRNA 3419 8561 13672 2,2 4.OOE-87 5174574 NT Homo sapiens myeloldllymphold or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 4 (MI-LT4) mRNA 2749 7833 13034 1.1 2.OOE-87 4885420 NT Homo sapiens high-mdbility group (nonhistone chromosomal) protein 4 (HIVIG4) mRNA 4880 9987 15069 0.8 2.OOE-87 BE175478.1 EST - HUMAN RCS-HT0580-200300-031- GO4 HT0580 Horno sapiens cDNA 1165 7867.0.8 1.OOE-87 7705683 NT - Homo sapiens putative glycolipid transfer protein (LO. C51054), mRNA 1413 6540 11713 0.9 1.OOE-87 AW361977.1 EST-HUMAN PM2-CTO265-141099-001- g04 CTO265 Homo saplens cDNA 1413 6540 11714 0.9 1.OOE-87 AW361977.1 EST HUMAN PM2-CTO265-141099-001- 904 CT0265 Homo sapiens cDNA 3649 8788 13881 3.2 1.OOE-87 Y00052.1 NT Human mRNA for T-cell cyclophilin 3673 8812 13906 2.5 1.OOE-87 4758827 NT Homo saplens neurexin Ill (NRXN3) mRNA 5057 10155 15231 1.0 1.OOE-87 U50949.1 NT Rattus norvegicus taste bud receptor protein TB 641 (TB 641) gene, complete cds 1090 6228 11379 2.5 9.OOE-88 AF167465.1 NT Homo sapiens double stranded RNA activated Protein kinase (PKR) gene, exon 12 1327 6456 11622 0.7 9.OOE-88 AB037820.1 NT Homo sapiens mRNA for KIAA1399 protein, partial cds 1327 6456 11623 0.7 9.OOE-88 AB037820.1 NT Homo sapiens mRNA for K1AA1 399 protein, parUal cds 3574 8713 13811 1.1 9.OOE-88 A1.163209.2 NT Homo sapiens chromosome 21 segment HS21 C009 4172 9298 14379 2.6 9.OOE-88 X91929.1 NT H.sapiens ECE-1 gene (exon 9) 4172 9298 14380 2.6 9.OOE-88 X91929.1 NT H.sapiens ECE-1 gene (exon 9) 4934 10040 15112 1.2 9.OOE-88 AB026898.1 NT Homo sapiens DNA, DLEC1 to ORCTL4 gene region, section 112 (DLECI, ORCTO, ORCTL4 genes, complete ods) 1787 6907 1.2 5.OOE-88 7661887 NT Homo sapiens KIAA0063 gene product (K1AA0063), mRNA Page 138 of 196 Table 4

2602 7692 12898 1.1 5.OOE-88 N89399.1 EST HUMAN K9719F Human fetal heart, Lambda ZAP Express Homo saplens cDNA done K9719 5' similar to ZINC FIN. GER PROTEIN HZF1 2970 8121 13228 0.9 5.OOE-88 AF1 14488.1 NT Homo saplens Intersectin short Isoform (ITSN) mRNA, complete ods 2978 8129 13236 0.9 5.OOE-88 AF1 14488.1 NT Homo sapiens Intersectin short Isoform (ITSN) mRNA, complete ods 2978 8129 13237 0.9 5.OOE-88 AF1 14488.1 NT Homo saplens Intersectin short Isolbrm (ITSN) mRNA, complete cds 3343 8487 2.3 5.OOE-88 A1693217.1 EST HUMAN wd68h08.xl NCI_CGAP_Lu24 Homo sapiens cIDNA done IMAGE:2336799 Ysimilar to contains Alu repetitive element;contains element MER22 MER22 repetitive element:

3491 8632 13744 0.9 5.OOE-88 AF1 14488.1 NT Homo saplens Interse Wn short isoform (ITSN).miRNA, complete ods 4631 9745 14842 0.9 5.OOE-88 AF1 14488.1 NT Homo sapiens Intersectin short Isoform (ITSN) mRNA, complete cds 207.5400 10527 1.5 3.OOE-88 4826831 NT Homo saplens Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) (MJD) mRNA 1770 6891 4.8 3.OOE-88 49038020 NT Homo sapiens zinc finger protein 259 (ZNF259) mRNA 2918 8069 13179 4.3 3.OOE-88 N66951.1 EST HUMAN za48f12.sl Scares fetal liver spleen INKS Homosapiens cDNA clone IMAGE:2958233' 4147 9273 14351 1.2 3.OOE-88 4501912 NT Homo sapiens a disintegrin and metalloproteinase domain 23 (ADAM23) mIRNA 4147 9273 14352 1,2 3.OOE-88 4501912 NT Horno saplens a disintegrin and metalloproteinase domain 23 (ADAM23) mRNA 1020 6160 11312 1.4 2.OOE-88 7305198 NT Homo saplens Calsenllin, presenilin-binding protein, EF hand transcription factor (CSEN), mRNA 1607 6734 11904 0.9 2.OOE-88 AF24621 9.1 NT Horno saplens SNARE protein kinase SNAK mRNA, complete cds 1716 6839 12018 1.5 2.OOE-88 AF246219.1 NT Homo sapiens SNARE protein kinase SNAK mRNA, complete cds 4328 9451 14539 1.9 2.OOE-88 5031666 NT Homo sapiens dynein, axonemal, light polypeptide 4 (DNAL4), mRNA 1710 6833 12013 0.6 9.OOE-89 4759149 NT Homo sa lens SMC (mouse) homolog, Y chromosome (SIVICY) mIRNA 2705 7790 12991 0.5 8.0OE-89 BE311557.1 EST-HUMAN 601142409F1 NIH MGQ_14 Homo sapiens cDNA done IMAGE:3506186 5' 426 5593 10726 1.4 7.OOE-89 7657213 NT Homo sapiens hormonally upregulated neu tumor-assodated kinase (HUNK), mRNA 426 5593 10727 1.4 7.OOE-89 7657213 NT Horno saplens hormonaliX upregulated neu tumor-assoclated kinase (HUNK), mRNA 4785 9896 14989 2.9 7.OOE-89 4557390 NT Homo saplens complement component 8. beta polypeptide (C813) mIRNA 4847 9954 15043 5.1 7.OOE-89 A1.045748.1 EST-HUMAN DKRp434E24q-rl 434 (synonym: htes3) Homo sapiens c[DNA clone WZp434E246 5' 1006 6146 11300 1.1 6.OOE-89 5803114 NT Homo sa lens Inner membrane protein, mitochonddal (mitofilin) (IMMT), mRNA 1601 6728 11898 1.9 6.OOE-89 4827015 NT Horno sapiens solute carrier family 4, anion exchanger, member 3 (SI-C4A3) mRNA 1601 6728 11899 1.9 6.OOE-89 4827015 NT Homo saffiens solute carrier family 4, anion exchanger, member 3 (SLC4A3) mRNA 2166 7275 12486 1.1 6.OOE-89 4506124 NT Homo saplin"s sednelthreonine- protein kinase PRP4 homolog (PRP4) mRNA 2383 7485 12686 0.7 6.OOE-89 4507788 NT Homo sapiens ubiquifinconjugafing enzyme E2L 3 (UBE2L3) mRNA 2383 7485 12687 0.7 6.OOE-89 4507788 NT Homo sapiens ubigultin- conjugating enzyme E2L 3 (UBE2L3) mRNA 3480 8621 13733 0.8 6.OOE-89 7661817 NT Homo sapiens I-ISPC1 59 protein (HSPC1 59), mRNA 4537 9656 14743 3.5 6.OOE-89 A13007866.2 NT Homo sapiens mIRNA for KIAA0406 protein, partial cds 4537 9656 14744 3.5 6.OOE-89 A13007866.2 NT Homo saplens mRNA for KIAA0406 protein, partial cds 5007 10109 15178 2.8 5.OOE-89 BE244323.1 EST-HUMAN TCBAP2E0383 Pedlatric pre-B cell acute lymphoblastic leukernia Baylor-HGSC proJect=TCBA Homo saplens cDNA done TCBAP0383 5007 10109 15179 2,8 5.0OE-89 BE244323.1 ESI_HUMAN TCBAP2E0383 Pedlatric pre-B cell acute lymphoblastic leukemia Baylor-HGSC project--TCBA Homo sapiens cDNA done TCBAP0383 Page 139 of 196 Table 4

Page 140 of 196 2847 7998 13095 1.6 3.OOE-89 AW976181.1 ESI.HUMAN EST388290 MAGE resequences, MAGN Homo sapiens cDNA 121 5570 10707 0.7.2.OOE-89 7706670 NT Homo saplens PXR2b protein (PXR2b), mRNA 121 5570 10708 0.7 2.OOE-89 7706670 NT Homo saplens PXR2b protein (PXR2b), mRNA 402 5570 10707 0.9 2.OOE-89 7706670 NT Horno saplens KR2b protein (PXR2b), mRNA 402 5570 10708 0.9 2.OOE-89 7706670 NT Homo saplens PXR2b protein (PXR2b), mRNA 519 5683 10804 0.8 2.OOE-89 AB037763.1 NT Homo sapiens mRNA for KIAA1342 protein, partial cds 1778 6899 12086 1,3 2.OOE-89 4503314 NT Homo saplens dlaWgjycerol kinase, gamma (90kID) (DGKG) mRNA 1778 6899 12087 1,3 2.OOE-89. 4503314 NT Homo saplens diacylgiycerol kinase, gamma (90k0) (DGKG) mRNA 2852 8003 13101 2.0 2.OOE-89 A1222095.1 EST-HUMAN q996c08.xl Soares_NFL. GBC-Sl Homo saplens cIDNA done IMAGE:1843022 Ysirn lar to gb:J04131 GAMMA-GLUTAMYLTRANSPEPTWASE 1 PRECURSOR (HUMAN);contains AJu repefidve element; 4053 9180 14263 1.5 2.OOE-89 AF089897.1 NT Homo saplens topolsomerase- related function protein (TRF4-2) mRNA, partial s4061 9188 14272 6.2 2.OOE-89 X58742.1 NT H.sapiens HCK gene for tyrosine idnase (M), exons 10-11 4061 9188 14273 6.2 2.OOE-89 X58742.1 NT H.sapiens I-ICK gene for tyrosine kinase (M), exons 10-11 4396 9518 14608 1.1 2.OOE-89 AJ007378.1 NT Horno sapiens GGT gene, exon 5 372 5548 10681 1.1 1.OOE-89 A1652927.1 EST-HUMAN wb40h06.xl NCLWAP - GC6 Horno sapions cDNA done IMAGE:2308187 YsimiJar to SW:BACI- HUMAN O1867 TRANSCRIPTION REGULATOR PROTEIN BACH1 1047 6187 11338 0.6 8.OOE-90 AL-163246.2 NT Homo sapiens chromosome 21 segment HS21C046 1048 6187 11338 1.0 8.OOE-90 AL163246.2 NT Homo saplens chromosome 21 segment HS21 C046 818 5968 0.9 7.OOE-90 AF223391.1 NT Homo saplens calcium channel alphal E subunit (CACNA1 E) gene, exons 7-49, and partial ods, alternatively spliced 3029 8181 13281 1.1 6.OOE-90 X91926.1 NT H.sapiens ECE-1 gene (exon 6) 3029 8181 13282 1,1 6.OOE-90 X91926.1 NT H.saplens ECE-1 gene (exon 6) 4134 9260 14341 7.3 6.OOE-90 8922398 NT Horno sapiens hypothefical protein FLJ10388 (FLA0388), mRNA 4134 9260 14342 7.3 6.OOE-90 8922398 NT Homo sap] ns hypothetical protein FLJ10388 (FI-J10388), mRNA 149. 5345 3.6 5.OOE-90 AB035344.1 NT Horno saplens TCL6 gene, exon 1-10b.

1175 6300 11463 0.5 5.OOE-90 U80226.1 NT Human gamma-aminobutyric acid transaminase mRNA, partial cds 2508 7604 12805 0.8 5.OOE-90 AF1 14487.1 NT Homo saplens intersectin long Isoform (ITSN) mRNA, complete cds 4440 9560 14656 3.1 5.OOE-90 4506354 NT Homo sapiens pregnancy-zone protein (PZP) mRNA 4507 9626 14718 1.1 5.OOE-90 AA705222.1 EST HUMAN zj82g10.si Soares_fetaLliveLspleen-INFLSS1 Homo sapiens cDNA clone IMAGE:461442 3' 4507 9626 14719 1.1 5.OOE-90 AA705222.1 EST-HUMAN zj82g10.sI Soaresfeta!_ilvei spleerLl NFL-S-S1 Homo saplens cDNA clone IMAGE:461442 3' 4571 9689 14783 1 0 5.OOE-90 AL135549.1 EST HUMAN DKFZP762P161-rl 762 (synonym: hme12) Homo saplens cDNA done DKFZp762P1616 5' 299 5485 10615 0.6 4.OOE-90 AF231920.1 NT Horno sapiens chromosome 21 unknown mRNA 299 5485 10616 0.6 4.OOE-go AF231920.1 NT Homo saplens chromosome 21 unknown mRNA 587 5747 10864 0.6 4.OOE-90 A1905559.1 EST-HUMAN CM-BT092-030299-022 BT092 Homo sapiens cDNA 1070 6208 11361 1.0_ 4.OOE-90 4505316 NT Horno saplens myosin phosphatase, target subunit 1 (MYPT1), mRNA 1663 6787 11964 3.3 4.OOE-90 X99033.1 NT H.sapiens gene encoding discoldin receptor tyrosine kinase, exon 16 4557 9675 14767 4.1 4.OOE-90 D87675.1 NT Homo sapiens DNA for arnylold precursor protein, complete cds Table 4

4691 9803 14904 2.0 4.OOE-90 A13033070.1 NT Homo sapiens mRNA for KIAA1244 protein, partial cds 4713 9825 14917 1.9 4.OOE-90 M95967.1 NT Human prohormone converting enzyme (NEC2) gene, exon 8 718 5872 0.6 3.OOE-90 W28189.1 EST HUMAN 43c5 Human retina cIDNA randomly primed sublibrary Homo sapiens cDNA 1156 6291 11445 1.2 2.OOE-90 5031748 NT Homo sapiens high-mobility group (nonhistone chromosomal) protein 17 (HMG17), mRNA 1156 6291 11446 1.2 2.OOE-90 5031748 NT Homo sapiens high-mobility group (nonhistone chromosomal) protein 17 (HMG1 7), mRNA 3771 8908 13997 2.8 2.OOE-90 A1138213.1 EST-HUMAN qc54c02.xl Soares_piacentk_Ctogweeks-2NbHP8togW Homo sapiens cDNA clone IMAGE:1713410 3'stmilar to SW..OLF3 MOUSE P23275 OLFACTORY RECEPTOR OR3.

4588 9702 14796 1,1 2.0012-90 AB006627.1 NT Homo saplens mRNA for KIAA0289 gene, partial cds 4820 9929 15020 8.3 2.OOE-90 5729855 NT Homo sapiens GR132-related adaptor protein (GRAP) mRNA 275 5463 10592 1.2 1.OOE-90 4502166 NT Homo saplens arnylold beta (A4) precursor protein (protease nexin-li, Alzheimer disease) (APP), mRNA 370 7861 10680 1.2 1.OOE-90 AF231920.1 NT Homo saplens chromosome 21 unknown mRNA 371 7861 10680 1.0 1.OOE-90 AF231920.1 NT Homo saplens chromosome 21 unknown mRNA 680 5835 10967 0.7 1.0OE-90 AJ237589.1 NT Homo saplens mRNA for T-box transcription factor (T13X20 gene), partial 680 5835 10968 0.7 1.0OE-90 AJ237589.1 NT Homo sapiens mRNA for 7Wx transcription factor (T13X20 gene), partial 713 5867 11004 2.6 1.0OE-90 AF264750.11 NT Homo saplens ALR-like protein mRNA, partial ods 713 5867 11005 2.6 1.OOE-90 AF264750.1 NT Homo sapiens ALR-like proWn mRNA, partial cds 1094 6232 -0.8 1.0OE-90 4507828 NT Horno saplens Kruppel-like factor 7 (ubiquitous) (KLF7), mRNA 1284 6414 11576 1.2 1.OOE-90 AF096154.1 NT Homo sapiens protein phosphatase 2A BR gamma subunit gene, exon 3 1284 6414 11577 1.2 1.0OE-90 AF096154.1 NT Homo saplens protein phosphatase 2A BR gamma subunit gene, exon 3 1644 6770 4,0 1.OOE-90 BE379884.1 EST - HUMAN 601159563F2 N11-1 MGC 53 Homo saplens cIDNA done IMAGE:3511118 51 2823 7974 13077 8,4 1.0OE-90 6005720 NT Horno sapiens chromosome 8 open reading frame 2 (C80 F2), mRNA 3777 8914 14005 1.2 1.0OE-90 A13020710.1 NT Homo sapiens mRNA for KIAA0903 protein, partial ods 3777 8914 14006 1.2 1.OOE-90 A8020710.1 NT Homo saplens mRNA for KIAA0903 protein, partial cds 4326 9449 14537 1.0 1.OOE-90 AF167340.1 NT Homo sapiens soluble Interleukin 1 receptor accessory protein (11-1 RAP) gene, exon 8, alternative exons 9 and complete ods, alternatively spliced 4101 9227 14312 5.5 8.OOE-91 D12234.1 EST - HUMAN HUM000S381 Liver HepG2 cell line. Homo saplens cDNA clone $3813' 1428 6555 11731 0.9 7.OOE-91 AF053768.1 NT Rattus norvegicus brain specific cortactin-binding protein CBP90 mRNA, partial cds 151 5347 10475 0.8 6.OOE-91 AW961150.1 EST-HUMAN EST373222 MAGE resequences, MAGF Horno sapiens cDNA 3429 8571 13683 1.5 5.OOE-91 AA702794.1 EST-HUMAN z190b04.sI Soares_fetaltiveLspicen-1 NFI.S_$11 Homo sapiens cDNA clone IMAGE:448015 3' 3601 8740 13834 6.0 5.OOE-91 BE074985.1 EST-HUMAN PM3-BT0583-170200-001- e06 BT0583 Homo sapiens cDNA 3601 8740 13835 6.0 5.OOE-91 BE074985.1 EST-HUMAN PM3-BT0583-170200-001- e06 BT0583 Homo saplens cDNA 4703 9815 14911 0.8 5.OOE-91 7110634 NT Homo sapiens chromosome 22 open reading frame 5 (W2ORF5), mRNA 4703 9815 0.8 5.OOE-91 7110634 NT Horno, sapiens chromosome 22 open reading frame 5 (C220RF5), mRNA 1223 6353 11517 2.5 4.0012-91 BE259124.1 EST HUMAN 601115508F1 NI!:LWC, _16 Homo sapiens cIDNA clone IMAGE:3356376 5' 3166 8315 13427 1.3 4.OOE-91 AF156776.1 NT Homo sapiens lysophosphaddic add acyltransferase-delta (I.PAAT-delta) mRNA, complete cds c C4 Page 141 of 196 Table 4

3166 8315 13428 1.3 4.OCE-91 AF156776.1 NT Homo saplens 1Y5OPhosphaddic acid acyltransferase-delta (I.PAAT-delta) mRNA, complete cds 2624 7714 12914 1,0 3.OOE-91 7706508 NT Homo saplens beta- ureldoproplonase (LOC51733), mRNA 2624 7714 12915 1.0 3.OOE-91 7706508 NT H6mo sapiens beta- ureldopropionase (LOC51733), mRNA 3297 8443 13552 1.8 3.OOE-91 AL-163283.2 NT Homo sapiens chromosome 21 segment HS21 C083 3416 8558 13668 3.0 3.OOE-91 A13033104.1 NT Homo saplens mRNA for KIAA1278 protein, partial cds 3416 8558 13669 3.0 3.OOE-91 AB033104.1 NT Homo saplens mRNA for KIAA1278 protein, partial cds 3720 8857 13950 0.8 3.OOE-91 AF084530.1 NT Horno sapiens cydin-D binding MyWilke protein mRNA, complete cds 4487 9607 14700 j.0 3.0012-91 M30938.11 NT Human Ku (p701p80) subunit mRNA, complet6 cds 4905 10012 15092 1.2 3.0012-91 AL163285.2 NT Homo saplens chromosome 21 segment HS21 C085 4905 1001 15093 1.2 3.OOE-91 AL163285.2 NT Homo sapiens, chromosome 21 segment HS21 C085 1699 7924 12004 0.9 2.OOE-91 AW845499.1 EST HUMAN MR1-CTO056-2411199-009- b07 CTO056 Homo sapiens cDNA 42 5252 10365 1.0 1.0OE-91 AL-163284.2 NT Homo sapiens chromosome 21 segment HS21 C084 1225 6355 11519 1.2 1.OOE-91 AW449746.1 EST HUMAN Ul-H-B]3-aks-d-01-0-Ul. sl NO-CGAP-SubS Homo sapiens cIDNA clone IMAGE:2735280 3, 435 7888 10733 0.8 9.0OE-92 AW858856.1 EST HUMAN RC3-CTO347-220300-015- 912 CTO347 Homo sapiens cIDNA 435 7888 10734 0.8 9.OOE-92 AW858856.1 EST-HUMAN RC3-CTO347-220300-01 "12 CTO347 Homo sapiens cDNA 1221 6352 11513 2.9 9.OOE-92 AJ001689.1 NT Homo sapiens NKG2D gene, exon 10 1221 6352 11514 2.9 9.OOE-92 A.1001689.1 NT Homo saplens NKG21) gene, exon 10 87 5293 10419 0.7 8.0OE-92 W26367.1 EST HUMAN 26f3 Human retina cIDNA randomly primed sublibrary Homo sapiens cIDNA 283.5470 10600 2.0 8.OOE-92 BE386363.1 EST HUMAN 601273513F1 NIH WQ_20 Homo saplens cDNA cJone IMAGE:3614667 5, 2738 7622 13026 0.9 B.DOE-92 BE396819.1 EST HUMAN 601290085F1 NiftiVIGCJ Homo sapiens cDNA clone IMAGE:3620469 S' 5268 10390 0.9 7.0OE-92 M60676.1 NT Human von Willebrand tctor pseud2gehe corresponding to exons 23 through 34 236 7884 10552 0.9 7.0OE-92 A13018301.1 NT Homo sapiens mRNA for KIAA0758 protein, partial cds 236 7884 10553 0.9 7.OOE-92 AB018301.1 NT Horno sapiens mRNA for KIAA0758 protein, partial cds 576 5736 1.3 7.OOE-92 AF007822.1 NT Homo saplens cytoplasmic Seprase truncated ltoform mRNA, complete cds 1259 6388 11549 0.7 7.OOE-92 4502384 NT Homo sapiens B-cell CLLAymphoma 7b (BCL7B) mRNA 2139 7249 12455 0.6 7.OOE-92 5031570 NT Homo sapiens ARP2 (actin-related protein 2, yeast) hornolog (ACTR2), mRNA 2139 7249 12456 0.6 7.OOE-92 5031570 NT Homo sapiens ARP2 (addn-related protein 2, yeast) homolog (ACTR2), mRNA 2517 7613 12815 0.8 7.OOE-92 AF167706.1 NT Homo sapiens cysteine-rich repeat-wntaining protein S52 precursor, mRNA, complete cds 2693 7780 12977 1.8 7.OOE-92 6005738 NT Homo sapiens NRAS-related gene (DIS155E), mRNA 2724 7808 13013 1.0 7.OOE-92 AB031007.1 NT Horno sapiens DNA, MI-IC class 1 region, 7.1 ancestral haplotype 3301 10296 13555 0.9 7.OOE-92 4507500 NT Homo sapiens T-cell lymphorna Invasion and metastasis 1 (TIAM1) mRNA 3301 10296 13556 0.9 7.OOE-92 4507500 NT Homo saplens T-cell lymphorna Invasion and metastasis 1 (TIAM1) mRNA 4484 9604 14697 1.6 7.OOE-92 S71824.1 NT N-CAM=145 kda neural cell adhesion molecule (human, small cell lung cancer cell line OS2 R, mRNA, 2960 nil 4484 9604 14698 1,6 7.OOE-92 S71824.1 NT N-CAM=145 kda neural cell adhesion molecule [human, small cell lung cancer cell line OS2 R, mRNA, 2960 ntl 5110 10206 15284 1.5 7.OOE-92 4506118 NT Homo sapiens prospero-related homeobox 1 (PROX1) mRNA 1569 6695 0.9 5.OOE-92 BE390882.1 EST_HUMAN 601283012F1 N11-1-1VIGQ_44 Homo saplens cDNA clone IMAGE:3605018 5' C1) r Page 142 of 196 Table 4

Page 143 of 196 23 552 10335 0.5 2.OOE-92 4501898 NT Homo saplens activin A receptor, type IIB (ACVR213) MRNA 732 5886 11029 1.4 2.OOE-92 BE299190.11 EST-HUMAN 601118337F1 NIM_MW 17 Homo sapiens cIDNA done IMAGE.3028304 f 732 5886 11030 1.4 2.OOE-92 BE299190.1 EST HUMAN 601118337F1 N1H MGCJ7 Homo sapiens cIDNA done IMAGE:3028304 5' 1686 6810 1.0 2.OOE-92 S78653.11 NT mrg=mas-related [human, Genomic, 2416 nt] 1894 7011 12199 0.6 2.OOE-92 A1818119.1 EST%_HUMAN wk27d07.xl NCI- CGAF_Bm25 Homo saplens cIDNA done IMAGE:2413549 3, similar to TR:012844 Q12844 BREAKPOINT CLUSTER REGION PROTEIN; 1894 7011 12200 0.6 2.OOE-92 A1818119.1 EST HUMAN wk27d07.xl NCI- CGAP_Brn25 Homo saplens cIDNA done IMAGE:2413549 Ysimilar to TR:Q12844 012844 BREAKPOINT CLUSTER REGION PROTEIN; 2002 7117 12319 1.7 2.OOE-92 4506860 NT Homo sapiens syndecan 4!Lamphigtycan, ryudocan) (SDC4) mRNA 2623 7713 12913 14.0 2.OOE-92 6912457 NT Homo saplens caldneurin binding protein 1 (K1AA0330), mRNA 3562 8701 13797 1.0 2.OOE-92 AF231919.1 NT Homo sapiens chromosome 21 unknown mRNA 3562 8701 13798 1.0 2.OOE-92 AF231919.1 NT Homo sapions chromosome 21 unknown mIRNA 3631 8770 13864 5.0 2.OOE-92 5803180 NT Homo saplens stress-inducedphosphoprotein 1 (Hsp70IHspgO-organizing protein) (STIP1), mRNA 4191 9317 14401 1.0 2.OOE-92 M10976.11 NT Human endogenous retroviral DNA (4-1), complete retroviral segment 4648 9760 14855 0.8 2.OOE-92 AF136523.1 NT Homo sapiens bile salt eMort pump (BSEP) mRNA, complete cds 4922 10029 2.5 2.OOE-92 AL040437.1 EST HUMAN DKFZp434C04114-rll 434 (synonym: htes3) Homo sapiens cDNA clone DKFZp434C04114 5' 1807 6926 12114 1.1 11.0OE-92 R78078.11 ESrHUMAN yi80e08.rl Soares placenta N1J2HIP Homo saplens cIDNA done IMAGE: 145574 5, 1807 6926 12119 1.1 11.0OE-92 R78078.11 EST HUMAN y180c08.rl Soares placenta Nb21r1P Homo sapiens cIDNA done IMAGE:145574 5, 2028 7141 12342 13.0 11.0OE-92 4506668 NT Homo sapiens dbosoffial protein, large, 121, (RPLP1) mRNA 1996 7112 3.3 9.OOE-93 AA316723.1 EST HUMAN EST188414 HW cell line (matastasis to liver In mouse) 11 Homo sapiens cIDNA Vend similar to dbosomal protein L29 2610 7700 0,5 9.OOE-93 AF223391.1 NT Homo saplens calcium channel alphalE subunit (CACNA11 E) gene, exons 7-49, and partial cds, alternatively ppliced 3563 8702 13799 1.0 9.OOE-93 BE388571.1 EST-HUMAN 601281867F1 NII- i_ffiGQ_44 Homo sapiens cIDNA done IMAGE:3603832 5' 246 5434 10560 2.1 7.0OE-93 AF231919.1 NT Homo saplens chromosome 21 unknown mRNA 3030 8182 2.4 7.0012-93 AL1163247.2 NT Homo saplens chromosome 21 segment HS21 C047 1359 6487 11653 1.3 5.OOE-93 AB014511.1 NT. Homo saplens mRNA for KIAA0611 protein, partial cds 1385 6512 11677 2.0 5.OOE-93 A1674184,1 EST_HUMAN wcO9cO8.xl NCI CGAP Pr28 Homo sapiens cIDNA done IMAGE:2314670 3, 1385 6512 11678 2.0 5.00IE-93 A1674184.1 EST_HUMAN wcO9cO8.xl NCI CGAP Pr28 Homo saplens cIDNA done IMAGE:2314670 3' 1459 6586 1.0 5.OOE-93 A1.163201.2 NT Horno saplens chromosome 21 segment HS21 C001 3195 8W 13457 2.4 5.0OE-93 X042011.1 NT Human skeletal muscle 1 3 kb mRNA for tropomyosin 82 5288 1.6 4,OOE-93 AA459933,11 ESTHUMAN zx50c09.sl Soares_tesdsLNHT Horno sapiens cDNA done IMAGE:795688 Ysimilar to SWCLIPkRAT P37397 CALPONIN, ACiDIC ISOFORM; 437 5603 10736 0.6 4.OOE-93 4557879 NT Homo sapiens Interferon gamma receptor 1 (IFNGR1) mRNA 437 5603 10737 0.6 4.00IE-93 4557879 NT Homo sapiens interferon gamma receptor 1 (IFNGRI) mRNA 755 5907 11054 1.3 4.2OE-93 7657454 NT Homo sapiens pescadlito (zebrafish) homolog 1, containing BRCT domain (PES1), mRNA 755 5907 11055 1.3 4.OOE-93 7657454 NT Homo sapiens pescadillo (zebrafish) homolog 1, cc. ntaining BRCT domain (PES1), mRNA Table 4

Page 144 of 196 1166 6300 11455 0,7 4.0012-93 8923658 NT Homo sapiens hypothetical protein FLJ20731 (FLJ20731), mRNA 1934 7051 12244 1.8 4.OOE-93 AF047677.1 NT Horno sa ns dystrophin (DIVID) gene, deletion breakpoints 1-3 in intron 5 2349 7451 12658 0.8 4.OOE-93 AL1 63301.2 NT Homo saplens chromosome 21 segment HS21 Cl 01 2564 7657 12860 0.8 4.OOE-93 7656972 NT Homo sapi ns TNIF-Inducible protein CG12-1 (CG1 2-11), mRNA 3962 9094 14179 1.4 4.OOE-93 4504654 NT Homo saplens interleukin 18 receptor 1 (11-18R1) mRNA 183 5377 10502 2.8 2.OOE-93 AB01 5610.1 NT Chlorocebus aethlops mRNA for dbosomal protein S4X, complete ods eds tein S4X, 183 5377 10503 2.8 2.OOE-93 AB015610.1 NT Chlorocebus aethlops mRNA for dbosomal p complete 320 5504 10632 2.3 2.OOE-93 AL163285.2 NT Homo sapiens chromosome 21 segment HS21C085 321 5504 10632 2.6 2.OOE-93 AL1 63285.2 NT Homo sapiens chromosome 21 segment HS21 C085 2083 7195 12400 1.0 2.OOE-93 4758105 NT Homo saplens C11k-assoclating RS- cydoph lin (CYP) mRNA 2436 7535 12742 069 2.OOE-93 BE2532011.1 EST HUMAN 601116810F1 NIH MGQ_116 Homo saplens cDNA done IMAGE:3357243 5' 5088 10186 15264 1.0 2.OOE-93 BE253201.1 ESI_HUMAN 601116810F1 NIH MGC 16 Homo saplens cIDNA clone IMAGE:3357243 5' 96 5303 10429 0.6 11.0OE-93 AF238997.1 NT Homo saplens CTR1 pseudogene 96 5303 10430 0.6 1.0OE-93 AF238997.1 NT Homo sapiens CTR1 pseudogene 507 5671 10794 0.9 1.OOE-93 7657016 NT Homo sapiens hypothetical protein (13.1328E1 9.Cl. 1), mRNA 585 5745 10862 1.3 11.0OE-93 A1146755.11 EST HUMAN oy84b08.xl NCI - WAP_CLI-11 Homo saplens cDNA clone IMAGE:1 672503 3'similar to TR:Q62384 Q62384 ZINC FINGER PROTEIN.; 854 66-0-3 11163 1.1 1.OOE-93 D87675.11 NT Horno sapiens DNA for arnylold precursor pro In, complete cds 1217 6347 11506 2,2 1.0012-93 8923270 NT Homo sa ns hypothetical protein FLJ20291 (FU20291), mRNA 1217 6347 11507 2,2 11.0OE-93 8923270 NT Homo saplens hypothetical protein FLJ20291 (FI-JJ20291), mRNA 1323 6452 11617 0.6 1.0OE-93 AF167706.11 NT Homo sapiens cysteine-rich repeat-containing protein S52 precursor, mRNA, complete cds 2289 7394 12602 1.0 1.OOE-93 AF231981.1 NT Homo sapiens long chain polyunsaturated fatty acid elongation enzyme (HEL01) mRNA, complete cds 2415 7514 12722 1.5 11.0OE-93 AF055066.1 NT Homo saplens MI-IC class 1 region 2459 7658 1.1 1.0012-93 A13037846.1 NT Horno sapiens mRNA for KI7uk1425 protein, partial cds 2792 6403 11562 0.9 1.0OE-93 BE297369.1 EST HUMAN 601177686F1 N1H MGC 17 Homo sapiens cIDNA done IMAGE:3532965 5' 2792 6403 11563 0.9 1.0012-93 BE297369.11 EST HUMAN 601177686F1 NIM_MGC 17 Homo sapiens cIDNA done IMAGE:3532965 5' 2903 8054 13159 4.3 11.0OE-93 D87675.1 NT Homo sapiens DNA for amytoid precursor protein, complete cds 4331 9454 14542 1.4 11.0OE-93 AIL163284.2 NT Homo saplens chromosome 21 segment HS21 C084 3880i 9016 14111 1.7 6.OOE-94 AF142482.1 NT Homo sapiens transcription; nhancer factor-5 mRNA, complete cels 1799 6919 1.7 4.OOE-94 L05094.1 NT Homo saplens dbosomal protein L27 mRNA, complete ods 2621 7711 12911 0.9 4.OOE-94 4506008 NT Homo saplens protein phosphatase 1, regulatory subunit 10 (PPP1R10) mRNA 4618 9732 14827 3.0 4.OOE-94 A1591312.1 EST-HUMAN twIl Ifl 0.xl NCI_WAP_Bm52 Horno, sapiens cDNA clone IMAGE:2259403 3'similar to TR:Q15265 015265 PROTEIN TYROSINE PHOSPHATASE; 595 57W 10871 1,2 3.OOE-94 A13022785.1 NT Horno sapiens ASH2L gene, complete cds, similar to Droso hila ash2 gene 704 5859 10994 1.2 3.OOE-94 4502506 NT Homo saplens complement component 5 (C5) mIRNA 1706 6829 12009 1.1 3.OOE-94 AF1167706.1 NT Homo sapiens cystelne-rich repeat-containing protein S52 precursor, mRNA, complete cds 1706 6829 12010 1.1 3.OOE-94 AF167706.1 NT Homo saplens cystelne-rich repeat-contalning protein S52 precursor, mRNA, complete cds Table 4

1735 6858 12036 1.3 3.OOE-94 4557556 NT Honno sapiens E1A binding protein p300 (E13300) mRNA 4695 9221 14304 0.8 3.OOE-94 AA464805.1 EST HUMAN zw63908.rl Soares- totaljetus_Nb2HF8._gw Homo saplens cDNA clone IMAGE:774782 5' 143 5339 10469 0.8 11.0OE-94 BE295714.1 EST-HUMAN 601175762F1 NiLMGC_17 Honno saplens cDNA done IMAGE:3531038 5' 616 5774 10895 1.5 1.ODE-94 8394483.1 EST-HUMAN tf79f03.xl NCI-CGAP_8m23 Honno saplens cIDNA done IMAGE:2105501 Ysimilar to TR:008764 008764 ANKYRIN.; 616 5774 10896 1.5 11.0OE-94 A1394483.1 EST HUMAN C79f03.xl NCLWAP3m23 Honno sapiens cDNA done IMAGE:2105501 Ysimilar to TR:008764 008764 ANKYRIN.; 3050 8201 13301 1,9 11.0OE-94 BE253433.1 EST HUMAN 601111696F1 Nit MGQ_116 Homo sapiens cIDNA done IMAGE:3352559 5' 3050 8201 13302 1.9 11.0OE-94 BE253433.1 EST-HUMAN 601111696F1 NIH MGC 16 Honno saplens cDNA done IMAGE:3352559 5' 1461 6588 11762 0.6 9.OOE-95 AF027302.1 NT Homo sapiens TNF.aipha stimulated ABC protein (ABC50) mRNA, complete cds 3118 8267 13371 1.1 9.OOE-95 7662027 NT Horno saplens KIAA0255 gene product (K1AA0255), mRNA 3118 8267 13372 1.1 9.OOE-95 7662027 NT Horno sapiens KIAA0255 gene product (K1AA0255), mRNA 4436 9557 14651 1.6 8.OOE-95 A1700998.1 EST HUMAN weO9eO4.xl NCI. _PGAP_Lu24 Horno saplens cDNA clone IMAGE:2340606 Ysimilar to gb:1K00558 TUBULIN ALPHA-1 CHAIN (HUMAN); 4436 9557 14652 1.6 8.0OE-95 A1700998.1 EST-HUMAN we09e04.xl NCLCGAP_Lu24 Horno saplens cDNA done IMAGE:2340606 3'similar to gb:1K00558 TUBULIN ALPHA-1 CHAIN (HUMAN); 274 SW- 10590 3.2 7.OOE-95 D87675.1 NT Horno sapiens DNA for amytold precursor protein, complete cds 274 5462 10591 3.2 7.OOE-95 b87675.1 NT Horno sapiens DNA for amyloid precursor protein, complete cds 4270 9395 14479 5.9 7.OOE-95 M95708.11 NT Homo sapiens LyMike protein (C1)59) mRNA, complete cds 4316 9439 1.4 7.OOE-95 AL163246.2 NT Horno saplens chromosome 21 segment HS21 C046 4982 10085 15155 1.0 7.0OE-95 M95929.1 NT Human homcobox protein (PHOX1) mRNA, 3' end 922 6069 11226 0.9 2.0012-95 4504374 NT Homo sapiens H factor 1 (compliament) (HFI) mRNA 1625 6751 11919 0.6 2.OOE-95 7662027 NT Horno sapiens KIAA0255 gene product (K1AA0255), mRNA 1625 6751 11920 0.6 2.OOE-95 7662027 NT Horno sapiens KIAA0255 gene product (K1AA0255), mRNA 1897, 7015 12204 2.8 2.OOE-95 4507512 NT Horno sapiens Ussue Inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) (TIMP3) mRNA 1900 7018 12208 1.2 2.OOE-95 BE393873.1 EST - HUMAN 601312161 F1 NIH_MGC 44 Homo sapiens cDNA clone IMAGE:3658862 5' 2376 7478 12679 1.3 2.0012-95 5453665 NT Homo saplens G protein-coupled receptor 19 (G1PR19) mRNA 2376 7478 12680 1.3 2.OOE-95 5453665 NT Homo sapiens G protein-coupled receptor 19 (GPRI9) mIRNA 2417 7516 12723 16.6 2.OOE-95 7657185 NT Homo saplens hyethedcal ptote)n (HS322BIA), mRNA 2466 7564 12767 0.9 2.OOE-95 4758423 NT Horno sapiens glydne deay;ge system protein H (aminomethA carder) (GCSH) mRNA 2787 6068 11225 0.9 2.OOE-95 4504374 NT Horno saplens H factor 1 (complement) (HF1) mRNA 3120 8269 13374 3.5 2.OOE-95 AF015452.1 NT Homo sapiens Usurpin-gamma mRNA, complete cds 3517 8658 13764 2.8 2.OOE-95 7705900 NT Horno, saplens unconventional myAin-15 (LOC51168), mRNA 3517 8658 13765 2.8 2.OOE-95 7705900 NT Homo saplens unconventional myosin-1 5 (LOC51 168), mIRNA 3565 8704 13800 1.0 2.OOE-95 AB037807.11 NT Horno, sapiens mIRNA for KIAA1386 protein, partial cds 3690 8829 13922 1.0 2.OOE-95 A1290264.1 EST HUMA qm011c02.xl SoareaLNhHMPLLSI Homo sapiens ciDNA clone IMAGE:1880546 Ysimilar to :T23G7.4 CE03705; 9389 14472 2.3 2.OOE-95 7657185 NT Homo saplens hypothetical protein (HS322BIA), mIRNA 4971 10074 15147 2,6 2.OOE-9 7661979 NT Horno sapiens K1AA01 87 gene product (K1AA01 87), mRNA lil C.1 C Page 145 of 196 Table 4

Page 146 of 196 5022 10123 15195 1.0 2.OOE-95 AA447931.1 EST-HUMAN zxl 1d07.rl Soares- total_letus-Nb2HF8-gw Horno sapiens cDNA eJone IMAGE:786157 5' 5022 10123 15196 1.0 2.OOE-95 AA447931.1 EST-HUMAN =1 1d07.rl SoareE_totai_jetus-Nb2HF8-gw Homo sapiens cIDNA. ejone IMAGE:786157 5' 1693 6817 11997 0.8 8.OOE-96 7657185 NT Homo sapiens hypothetcal protein (HS322B1A), mRNA 1693 6817 11998 0.8 8.OOE-96 7657185 NT Homo saplens hypothetical protein (HS322BIA). mRNA 3834 8971 14070 1.0 7.OOE-96 AF231920.1 NT Homo saplens chromosome 21 unknown mRNA 4450 9570 14668 2.0 7.OOE-96 AW404800.1 EST HUMAN Ul-HF-131-0-acm-d-1 1-0- Ul.rl NIH-MGC-37 Homo saplens cDNA clone IMAGE:3059397 5, 4450 9570 14669 2,0 7.OOE-96 AW404800.1 EST-HUMAN Ul-HF-BLO-acm-d-11-0-Ul, rl NIH-MGC-37 Homo sapiens cIDNA clone IMAGE:3059397 5' 2213 7321 12535 0.9 6.OOE-96 BE171984.1 ESTHUMAN MRO-HT0559-250200-002- d07 HT0559 Homo sapiens cDNA 3276 8421 13529 1.0 6.OOE-96 AL163201.2 NT Homo saplens chromosome 21 segment HS21 C001 3437 8579 13691 26.2 6.OOE-96 M26873.11 NT Human gi raidehyde-3-p7osphate dehydrogenase pseudogene Yend 317 5501 10628 0.9 5.OOE-96 AB032998.1 NT Honno saplens mRNA for K1AA1 172 protein, pardal cds 824 5973 1.1131 1.0 5.OOE-96 AB032998.1 NT Homo saplens mRNA for K1AA1 172 protein, partial cds 824 5973 11132 1.0 5.OOE-96 A13032998.1 NT Homo sapiens mRNA for K1AA1 172 protein, partial cds 2991 8143 13245 1.0 5.OOE-96 6912735 NT Homo sapi ns transient receptor potential channel 5 (TRPC5), mRNA 4810 9920 1.2 5.OOE-96 X608112.1 NT H.sapiens DNA for monoamine o)ddase type A (7) (partial) 4097 9223 6.2 3.OOE-96 H68656.1 EST-HUMAN yr87h12xl Scares fetal liver spleen 1 NFLS Homo sapiens cIDNA clone IMAGE:212327 5 409 5577 1 2 2.OOE-96 4503098 NT Homo sapiens chondroidn sulfate proteoglycan 4 (melanoma-associated) (CSPG4). mRNA 730 58B4 11026 0.5 2.OOE-96 AL1 63248.2 NT Horno sapiens chromosome 21 segment HS21 C048 4651 9763 14858 1.6 2.OOE-96 BE148074.1 EST-HUMAN RC3-HT0230-040500-1 1 0- g02 HT0230 Homo sapiens cDNA 655 5F172 10940 0.6 1.OOE-96 Y18890.1 NT Human endogenous retroArus type K (HERV-K), gag, pol and env genes 1742 6865 12042 0.7 1.0012-96 AW955054.1 EST HUMAN EST367124 MAGE resequences, MAGC Homo sapiens cDNA 1742 6865 12043 0.7 1.OOE-96 AW955054.1 EST HUMAN EST367124 IMAGE resequences, MAGC Homo saplens cDNA 1806 6925 12112 0.9 1.OOE-96 4503756 NT Honno saplens flavin containing monooxygenase 2 (FM02) mRNA 1806 6925 2113 0.9 1.OOE-96 4503756 NT Homo saplens flavin containing monooxygenase 2 (FIVI02) mRNA 2080 7192 12395 0.9 1.OOE-96 AF167706.1 NT Homo sapiens cystelne-rich repeat-containing protein S52 precursor, mRNA, complete cds 2080 7192 12396 0.9 1.OOE-96 AF167706.1 NT Homo sapiens cystelnedch repeat-containing protein S52 precursor, mRNA, complete cds 2181 7290 12501 1.3 1.OOE-96 M75967.1 NT Human hepatopM growth factor gene, exon 1 2181 7 5-0 12502 1.3 1.OOE-96 M75967.1 NT Human hepatocyte growth factor gene, exon 1 2219 7872 12541 0.7 1.OOE-96 U51472.2 NT Fells catus superfast myosin heavy chain (sMyHC) mRNA, complete cds 924 6071 11229 1.3 4.OOE-97 BE004436.1 ESTHUMAN CMO-BN0106-170300-293-a06 BN0106 Horno saplens cDNA 1868 6986 12170 1 1 4.OOE-97 5453572 NT Homo sapiens brefeldin A- inhibited quanine nucleofide-exchange protein 2 (BIG2), mRNA 5432 10558 1 3.OOE-97 AB03 998.1 NT Homo sapiens mRNA for K1AA1 172 protein, partial cds Table 4

Page 147 of 196 520 5684 10805 1.1 3.OOE-97 AA042813.1 EST-HUMAN zk53c07.si Soares_pregnant - uterup_NbHPU Homo saplens cIDNA done IMAGE:486540 3' similar to qb:X65857_Msli OLFACTORY RECEPTOR-LIKE PROTEIN HGW07E (HUMAN); 856 6005 11165 3.7 3.OOE-97 4502166 NT Homo sapiens arnylold beta (A4) precursor protein (protease nexin-l I, Alzheimer disease) (APP), inRNA 856 6005 11166 3.7 3.OOE-97 4502166 NT Homosaplens arnylold beta (A4) precursor protein (protease nexin-li, Alzheirrier disease) (APP), mRNA 1423 7916 11727 0.6 3.OOE-97 4758g13 NT Homo saplens N-myc (and STAT) interactor (NMI), mRNA 2389 7874 12693 0.7 3.OOE-97 U36255.1 NT Human beta-pdme-adapfin (BAM22) gene, exon 7 3223 8371 13480 1.1 3.OOE-97 5174478 NT Horno sapiens pericentrin (PCNT) mRNA 4670 9782 14881 12.6 1.0OE-97 4503470 NT Homo sapiens eukaryobc translation elongation factor 1 alpha 1 (EEFIA11) mRNA 883 6031 11190 2,7 9.OOE-98 BE090973.1 EST HUMAN PM4-13T0724-010400-008- a12 BT0724 Homo sapiens cIDNA.

1255 6384 11544 1.3 9.OOE-98 8393092 NT Homo sapiens cat eye syndrome critical region gene 1 (CECR1), mRNA 62 5270 10391 0.5 8.OOE-98 4759329 NT Horno sapiens Tesds-specific M- related protein on Y (WRY) mRNA 62 5270 10392 0.5 8.OOE-98 4759329 NT Homo saplens Testis-specific W- related protein on Y (WRY) mRNA 1350 6478 11644 0.9 8.OOE-98 AB033768.1 NT Homo saplens WAD-colony10 mRNA for pepfidylarginine deiminase type 1, complete cds 1540 6666 11835 1.0 8.0015-98 5031810 NT Horno sapiens IL2-1nducibleTcell kinase (ITK), mRNA 1540 6666 11836 1.0 8.OOE-98 5031810 NT Homo saplens 111-2-1ndudble T- cell kinase (ITIK), mRNA 1695 6819 12000 1.0 8.OOE-98 AB017007.1 NT Homo sapiens PMS2LI6 mRNA, partial ods 1695 6819 12001 1.0 8.OOE-98 AB017007.1 NT Homo sapiens PMS2LI6 mRNA, partial ods 3726 8863 13956 5.0 8.OOE-98 J04469.1 NT Human mitochondrial creatilne kinase (CKMT) gene, complete cds 5049 10149 0.9 8.OOE-98 AL163201.2 NT Horno sapiens chromosome 21 segment HS21C001 2565 7658 12861 0.7 3.OOE-98 AB014607.1 NT Homo sapiens mRNA for KIAA0707 protein, partial ods 2720 7804 0.8 3.OOE-98 AA077498.1 EST-HUMAN 7B18Hol Chromosome 7 Fetal Brain cIDNA Library Homo sapiens cIDNA done 7B18H01 2033 7146 12348 11.0 2.0015-98 BE294281.1 EST HUMAN 601172658F1 N1H MGQ_17 Horno sapiens cDNA done IMAGE:3528134 5' 2191 7300 12515 0.5 2.00IE-98 AL163202.2 NT Homo sapiens chromosome 21 segment HS21C002 2674 7761 12961 0.7 2.OOE-98 7662405 NT Homo s ens KIAA0957 protein (K1AA0957), mRNA 4244 9369 14448 4.9 2.OOE-98 4758331 NT Horno sapiens fatty-add-Coegzyme A ligase, long-chaJn 4 (FACL4) mRNA 4720 9832 14922 1.5 2.OOE-98 AF218902.1 NT Homo sapiens attractin precursor (ATRN) gene, exon 16 4720 9832 14923 1.5 2.OOE-98 AF218902.1 NT Homo sapiens attractin precursor (ATRN) gene, exon 16 5069 10167 15243 6.4 2.0012-98 9055269 NT Horno sapiens low density llpoprotein receptor related protein-deleted In tumor (LRPDIT), mRNA 5069 10167 15244 6.4 2.OOE-98 9055269 NT Homo saplens low density 11poproteln receptor related protein-deleted In tumor (LRPDIT), mRNA 5163 10257 15327 1.1 2.OOE-98 4758975 NT Homo saplens protein tyrosine kinase 2 beta (PTK2B) mIRNA 399 5567 10704 18.9 11.0OE-98 A1862007.1 ES7_HUMAN tw36b04.xl NCI- CGAP_Utl Homo sapiens cDNA done IMAGE:2261743 3' similar to SW:R1.2kHUMAN P29316 60S RIBOSOMAL PROTEIN L23A.; 447 5613 10744 0.8 11.0OE-98 AW99861 1.1 EST_HUMAN PMO-BN0065-100300-001- c06 8NO065 Homo sapiens cIDNA 1756 687 12058 6.1 1.OOE-98 N49818.1 EST&-HUMAN yv23f05.rl Soares fetal liver spleen I NFLS Homo sapiens cDNA clone IMAGE:243585 5' similar to PIR:S54204 S54204 ribosomal protein L29 - human; Table 4

1975 7090 12291 0.9 7.OOE-99 4759149 NT Homo sapiens SIVIC (mouse) homolog, Y chromosome (SMCY) mRNA 1975 7090 12292 0.9 7.OOE-99 4759149 NT Homo sapiens SMC (mouse) homolog, Y chromosome (SMCY) mRNA 3814 8951 14049 1.9 6.OOE-99 AW976364.1 EST-HUMAN EST388473 MAGE resequpnces, MAGN Homo sapiens cDNA 4642 9756 148W 1.2 6.OOE-99 4502660 NT Homo saplens CD34andgen (CD34) mRNA 902 6549 11203 0.9 5.00IE-99 U35464.1 NT Human protein C inhibitor (PCI- B) mIRNA, complete cds 902' 6049 11204 0.9 5.OOE-99;U35464.1 NT Human prote) C inhJbJtor (PCI-B) mRNA, complete cds 19= 7039 12228 0.9 5.OOE-99 Y1 1365.1 NT H.sapiens IMPA gene, exon 8 4463 9583 14680 1.4 5.OOE-99 AF009660.1 NT Homo sapiens T cell receptor beta locus, TCRBV7S3A2 to TCRBVI 2S2 region 5066 10164 15241 2.5 5.OOE-99 4758697 NT Homo sapiens mannosidase, alpha, class 2A, member 1 (MAN2A1), mRNA 375 5551 10684 1.0 2.OOE-99 AW385237.1 EST HUMAN PM1-HT0454-301299-001- 904 HT0454 Homo sapiens cDNA 1219 6350 1.2 2.OOE-99 AW274792.1 EST-HUMAN xpO9eO6.xl NCI - CGAF_HN9 Homo saplens cIDNA clone IMAGE:2739874 Ysimilar to qb:M31212 MYOSIN LIGHT CHAIN ALKALI, NON-MUSCLE ISOFORM (HUMAN); 3220 8368 13479 1.1 2.OOE-99 M30938.1 NT Human Ku (p7WO) subunit mRNA, complete cos 4443 9563 14659 3.2 2.OOE-99 AF095703.1 NT Homo sapiens short chain L-3- hydroxyacyl-CoA dehydrogenase precursor (HADHSC) gene, nuclear gene encoding mitochondrial protein, complete cds 312 5496 10625 0.5 1.OOE-99 AF1 14487.1 NT Homo saplens intersectin long Isoform (ITSN) mRNA, complete cds 1401 6528 11698 0.8 1.OOE-99 M30938.1 NT Human Ku (p701p80) subunit mRNA, complete cds 1537 6663 11830 0,5 1.OOE-99 AF192523.1 NT Homo sapiens truncated Niemann- Pick C3 protein (NPC3) mRNA, complete eds 1537 6663 11831 0.5 1.OOE-99 AF192523.1 NT Homo sapJens truncated Niemann- Pick C3 protein (NPC3) mRNA, complete cds 1885 7003 12188 1.1 1.OOE-99 4503730 NT Homo saplens FK506-binding protein 6 (36kD) (FKBP6) mIRNA, and translated products 1885 7003 12189 1.1 1.OOE-99 4503730 NT Horno sapiens FlKW6-binding protein 6 (36kD) (FKBP6) mR A, and translated products 3046 8197 13298 0.9 1.OOE-99 J03171.1 NT Human Interferon-alpha receptor (HuIFN-alpha-Rec) mRNA, complete cds 4283 9408 14492 2.7 1.OOE-99 AF098018.1 NT Homo saplens fatty acid amide hydrolase (FAAH) gene, exon 14 4283 9408 14493 2.7 1.OOE-99 AF098018.1 NT Homo saplens fatty acid amide hydrolase (FAAH) gene, exon 14 5200 10291 1.2 1.OOE-99 AL1 63281.2 NT Homo sapiens chromosome 21 segment HS21 C081 1 5211 10312 1.1 1.0OE-100 A1.163247.2 NT Homo sapiens chromosome 21 segment HS21 C047 2 5211 10312 0.7 1.OOE-100 AL1 63247.2 NT Homo sapiens chromosome 21 segment HS21 C047 81 5287 10415 0.5 1.0OE-100 AW275237.1 EST-HUMAN xv78bl 1.xl NCI_WAP Bm53 Homo sapiens cDNA done IMAGE:2824605 3' 162 5357 10482 1.2 1.OOE-100 A1.163206.2 NT Homo sapiens chromosome 21 segment HS21 C006 314 5498 10627 1.0 1.OOE-100 AL163249.2 NT Homo saplens chromosome 21 segment HS21 C049 340 5521 10646 0.8 1.0012-100 T05087.1 EST HUMAN EST02975 Febl brain, Stratagene (cat#936206) Homo sapiens cDNA done HFBCR32 430 5597 0.5 1.OOE-100 AF003528.1 NT Homo sapiens X-linked anhidrolfic ectodermal dysplasia protein gene (EDA), exon 2 and flanking repeat regions 481 5647 2,4 1.OOE-100 X89631.1 NT G.gorilia DNA for ZNF80 gene homolog 500 5664 10787 1.4 1.OOE-100 BE180609.1 EST HUMAN RC3-HT0625-040500-022- b09 HT0625 Homo sapiens cDNA 969 6114 11273 4.3 1.OOE 100 7705430 NT Homo sapiens hypothe cal protein (HSPC016), mRNA 1002 6142 11295 0.8 1.OOE-100 7661685 NT Homo saplens DKFZP586M0122 protein (DKFZP586M0122), mIRNA 1002 6142 11296 0.8 1.0OE-100 7661685 NT Homo sapiens DKFZP586M0122 protein (1)KFZ12586M0122), mRNA 1528 6655 1.3 1.0012-100 AW207555.1 ES-_HUMAN Ul-H-B 11-afk-o-07-0-Ul.sl NCI-CGAP-Sub3 Homo sapiens cIDNA clone IMAGE:2722164 31 rIja m C Page 148 of 196 Table 4 qf62f09.xl Soares---testis - NHT Homo saplens cIDNA clone IMAGE:1754633 Ysimilar to 1533 6659 11826 0.5 1.0012-100 A1200857.1 EST HUMAN SW:CW _ COTJA P81061 CYSTATIN; 2195 7304 0.5 1.OOE-100 D83349.1 NT Rat mRNA for short type PB-cadherin, complete cds 2294 7398 12607 1.5 1.0012-100 AW937782.1 EST HUMAN QV3-DT0045.140200-082- el 1 DT0045 Homo sapiens cIDNA 2388 7489 12692 1.1 1.OOE-100 AF164788.1 NT Pan troglodytes interferon gamma precursor (ifnG) mRNA, partial ods 2464 7562 12766 0.7 1.OOE-100 W26450.1 EST HUMAN 30a2 Human retina cDNA randomly primed sublibrary Homo sapiens cIDNA.

2985 8137 2.5 l.QOE-1 D1 1078.1 NT Homo saplens RGH2 gene, retrovirusAlke element 4116 9242 14328 1.5 1.OOE-100 AF057354.1 NT Homo saplens myotubularIn- related protein la mRNA, partial cds 4143 9269 14348 1.9 1.OOE-100 4503792 NT Homo sapiens follicle stimulating hormone receptor (FSHR) mRNA 5024 10125 15197 3.1 1.0OE-100 5032104 NT Homo sapiens small optic lobes (Drosophila) homolog (SOLH) mRNA 5024 10125 15198 3.1 1.6OE-100 5032104 NT Homc, sapiens' small opfic lobes (Drosophila) homolog (SOLF1) mRNA 5277 10403 1.2 1.0OE-101 7110714 NT Homo saplens SEC14 (S. cerevislac)- iike 2 (SEC141-2), mRNA 5277 10404 1.2 1.OOE-101 7110714 NT Homo saplens SEC14 (S. cereAsiae)41ke 2 (SEC141.2), mRNA 671 5827 10954 1.2 1.OOE-101 AB007915.2 NT Homo sapiens mRNA for KIAA0446 protein, partial cds 688 5843 10979 1.5 1.0OE-101 7110734 NT Homo sapiens ventral anterior homeobox 2 (VAX2), mRNA 688 5843 109801 1.5 1.0OE-101 7110734 NT Homo saplens ventral anterior homeebox 2 (VAX2), mRNA 754 5906 11053 1.3 1.OOE-101 7657454 NT Horno sapiens pescadillo (zebrafish) homolog 1, containing BRCT domain (PES1), mRNA Homo sapiens phosphodbosyigiycJnamide formyitransferase, phosphortbosyigiycinamide 835 5984, 11144 1.3 1.OOE-101 4503914 NT synthetase, phosphodbosylaminolmidazole synthetase (GART) mRNA 908 6054 11211 1.2 1.0012-101 Z20656.1 NT Horno sapiens of cardiac alphamyosin heavy chain gene 1036 6176 11328 0.6 1.OOE-101 A1221878.1 EST-HUMAN qg99e09.xl Soares NFk T GE1Q_S1 Homo sapiens cDNA done IMAGE:1 843336 3' 1712 6835 12015 0.9 1.OOE-101 7662183 NT Homo sapiens KIAA0569 gene product (K1AA0569), mRNA 1712 6835 12016 0.9 1.OOE-101 7662183 NT Horno saplens KIAA0569 gene product (K1AA0569), mRNA 1901 7019, 12209 0.6 1.OOE-101 4502996 NT Homo sa lens carboxypeptidase Al (pancreatic) (CPA1) mRNA 2010 7124 12324 0.6 1.OOE-101 X97869.1 NT H.sapiens gene encoding La autoandgen 2301 7940 12612 0.6 1.OOE-101 " 5729892 NT Homo sapiens A kinase (PRKA) anchor protein 6 (AKAP6), mRNA 2572 7665 12867 1.6 1.0012-101 Y07848.11 NT Homo saplens EWS, gar22, rrp22 and barn22 genes 2714 7798 13000 0.9 1.OOE-101 AJ237744.1 NT Homo sapiens RIBOR gene (partial), exon.12 2714 7798 130011 0.9 1.OOE-101 AJ237744.1 NT Homo saplens RIBI1R gene (partial), exon 12 2925 8076 12.1 1.OOE-101 AJ252312.1 NT Homo sapiens genomic downstream Rhesus box 3167 8316 13429 2.5 1.OOE-101 4885270 NT Homo saplens gamma- glutamyitransferase 1 (GGT1) mRNA 3334 8478 13591 1.7 1.OOE-101 AW965556.1 EST HUMAN EST377629 MAGE resequences, MAGI Horno sapiens cDNA 3354 7798 13000 1.8 1.OOE-101 AJ237744.1 NT Homo sapiens RIBI1R gene (partial), exon 12 3354 77981 13001 1.8 1.0OE-1101 AJ237744.1 NT Homo sapi ns RIBI1R gene (pardal), exon 12 3757 88951 13986 1.4 1.0OE-101 AF145712.1 - NT Homo sapiens soluble neuropilin-1 mRNA, complete ods 3800 89371 14031 4.8 1.OOE-101 AB022785.1 NT Homo saelens ASH2L gene, complete ods, similar to Drosophila ash2 gene 4965 100681 15141 1.7 1.OOE-101 5921460 NT Horno saplens butyrophilin, subfamily 2, member AI (STN2A1), mRNA 4965 100681 15142 1.7 1.OOE-101 5921460 NT Horno sa lens butyrophifin, subfamily 2, member A1 (BTN2A1), mRNA F- Homo sapiens chromosome 21 segment HS21 Cl 03 338 5519 1OW 1.1 1 1.6OE-102 JAL1 63303.2 INT Page 149 of 196 Table 4

604 5762 10882 0,9 11.0OE-102 BE252470.11 EST-HUMAN 601108292F1 N1H MGC16 Homo saplens cIDNA done IMAGE:3344326 5' 748 5900 11047 0.7 11.0OE-1 02 D30612.11 NT Homo saplens mIRNA for repressor protein, partial cds 758 5910 11058 1.5 11.0OE-102 4557534 NT Homo sapiens down-regulated In adenoma (DRA) mIRNA 1101 6239 11391 0.7 1.OOE-102 M10976.1 NT Human endogenous retroviral DNA (4-11), complete retroviral segment 1398 6525 11694 33.0 11.0OE-1 02 BE408447.1 EST HUMAN 601299982F1 N1H MGC 21 Homo sapiens cIDNA done IMAGE:3629901 5' 2157 7266 12476 0,7 1.OOE-102 AF182645.1 NT Homo sapiens chondrosarcoma- associated protein 2 (CSA2) mIRNA, complete cds 2261 7367 12576 1.3 11.0OE-102 A1950528.11 EST-HUMAN wx51e07.xl NCI CGAP Lu28 Horno sapiens cDNA clone IMAGE:2547204 Ysimilar to SW:GG95 HUNiAN Q08379 GOLGIN-95.;contains element MER22 repetitive element; 2261 7367 12577 1,3 11.0OE-102 A1950528.1 EST HUMAN wx51e07.xl NCI_MAP- LU28 Homo saplens cDNA done IMAGE:2547204 Ysimilar to SW:GG95 HUMAN Q08379 GOLGIN-95.;contains element MER22 repetitive element; 3026 8178 13279 1.5 1.0OE-1102 7661979 NT Homo sapiens KIAA0187 gene product (K1AA0187), mRNA 4139 9265 14346 1.5 1.OOE-102 AIL163207.2 NT Homo saplens chromosome 21 segment HS21 C007 4314 9437 14526 2,1 11.0OE-102 BE251310.1 EST-HUMAN 601107843F1 N1H MGQ_116 Homo sapiens cDNA done IMAGE:3343882 5' 5063 10161 15237 1.1 11.0OE-102 R66488.1 EST-HUMAN y132c04.rl Soares placenta Nb2HP Homo sapiens cIDNA done IMAGE: 140934 51 93 6300 10426 2.8 1.OOE-103 D87078.2 NT Horno sapiens mIRNA for KIAA0235 protein, partial ods 201 5395 10521 0.8 11.0OE-103 5453793 NT Horno saplens nudeolar protein (KKE/D repeat) (NOP56) mIRNA 1578 6704 11874 0.8 11.0OE-103 AF012872.1 NT Homo saplens phosphafidylinositol 4-kinase 230 (p14K230) mIRNA, complete cds 1872 6990 12175 1.0 1.0OE-1103 7657592 NT Homo sapiens srng GIDS- ASSOCIATED PROTEIN (SMAP), mRNA 1932 7049 12240 1.3 1.OOE-103 4502428 NT Homo sapiens bone morphogenetic protein 8 (osteogenic protein 2) (BMP8) mRNA 1932 7049 12241 1.3 1.OOE-103 4502428 NT Homo saplens bone morphogenetic protein 8'.(osteogenic protein 2) (13MP8) mIRNA 2257 7363 12572 0.6 1.0OE-1103 5803184 NT Homo sap! ns synaptophysin-like protein (SYPIL), mRNA 2401 7500 12707 0.8 11.0OE-103 AF060568.1 NT Homo sapiens promyelocytic leukernia zinc finger protein (PLZF) gene, complete cds 2578 7671 12872 0.9 11.0OE-103 N32770.1 EST HUMAN yw9ldO8.sl Soares_piaoenta-8togweeks-2NbHP8togW Homo sapiens cDNA clone IMAGE:259599 3 3333 8477 13590 3.4 11.0OE-103 AW298245.1 EST-HUMAN W-H-13WO-ajt-h-11 1-0- 1.11s11 NCI-CG,AIR-SO6 Homo sapiens cDNA clone IMAGE:2733165 3, 3393 8535 13640 1.1 11.0OE-103 AB040892.1 NT Horno sapiens mRNA for KIAA1459 protein, partial cds 3592 8731 1,3 11.0OE-1103 AL.048453.2 EST HUMAN DIKIFZp586J11 1124j11 586 (synonym., hutel) Horno sapiens cDNA clone DKFZp586J1 124 3695 8834 2.4 11.0OE-103 AF023861.1 NT Macaca mulatta cyclophilin A mIRNA, complete cds 3725 8862 13955 1.2 1.0OE-1103 AA485663.1 EST-HUMAN ablOdl2.sl Stratagene lung (#937210) Horno sapiens cDNA clone IMAGE:840407 Ysimilar to contains element LTR10 repetitive element; 3922 9056 14143 3.0 1.OOE-103 T23683.1 EST HUMAN seq340 b4HB3MA-CotlOg+10- Bio Homo sapiens cIDNA done b4HB3MA-CotlOg+10-Bio-7 3 233 5424 1OW 0.9 11.0OE-104 AL037549.3 EST-HUMAN DKRip564H1072-rl 564 (synonym: Mbr2) Homo sapiens cDNA clone 13KFZp5641-11072 S' 233 5424 10549 0.9 1.0OE-104 AL037549.3 EST HUMAN DKFZp5641-111072_rl 564(synonym: Wbr2)1-1omosapiens eDNAcione DKFZp5641-110725' 579 5739 108551 1.1 11.0OE-104 AA4961139.1 EST-HUMAN zv511f11 1.sl Soares- tesds-NHT Homo sapiens c1DNA done IMAGE:757197 Ysimilar to TR:G487738 G487738 PUTATIVE POTASSIUM CHANNEL SUBUNIT.; 579 5739 10856 1.1 1.OOE-104 AA496139.1 EST-HUMAN zv51f11.sl Soares - testis NHT Homo saplens cIDNA. done IMAGE:757197 3'sImilar to TR:G487738 G487738 PUTATIVE POTASSIUM CHANNEL SUBUNIT.; C Page 150 of 196 Table 4

1845 6963 12149 0.7 11.0OE-104 4502428 NT Homo sapiens bone morphogenedc protein 8 (osteogenic protein 2) (13MP8) LnRNA 1898 7016 1.9 1.OOE-104 AW054828.1 EST HUMAN ws60d04.xl NCI - CGAF_Bm25 Homo sapiens cDNA clone IMAGE:2501575 Ysimilar to TR:Q13541 Q13541 4E-BINDING PROTEIN l.; 2147 7257 12464 2.6 1.OOE-104 M34671.1 NT Human lymphocydc antigen CD59/MEM43 mRNA, complete cds 2318 7421 12629 1,2 1.0012-104 AF167706.1 NT Homo sapiens cystelne-dch repeat-containing protein S52 precursor, mRNA, complete cds 2318 7421 12630 1.2 1.OOE-104 AF1 67706.1 NT Homo sapiens cystelne-dch repeat-containing protein S52 precursor, mRNA, complete cds 2387 7488 12691 0.6 1.OOE-104 5031570 NT Homo sapiens ARP2 (actin-related protein 2, yeast) homolog (ACTR2), mRNA 2842 7993 13091 7.6 1.OOE-104 M346711.1 NT Human lym hocydc antigen CD59/MEM43 mRNA, complete cds 2886 8037 2.8 1.0012-104 Y1 1151.1 NT H.sapiens gene encoding phenylpyruvate tautomerase 11 3345 8489 1.5 11.0OE-104 AA319436.1 EST HUMAN EST21658 Adrenal gland tumor Homo saplens cDNA 5' end 3550 8690 13792 1.0 1.OOE-1o4 AB0331102.1 NT Homo sapiens mRNA for WAA1276 protein, partial cds 3550 8690 13793 1,0 11.0OE-1104 AB033102.1 NT Homo saplens mRNA for KIAA1276 protein, partial cds 3861 8997 14096 0.9 1.OOE-104 AB032998.1 NT Homo sapiens mRNA for K1AA1 172 protein, partial cds 4280 9405 14489 4.3 1.OOE-104 X02761.11 NT Human mRNA for fibronectin (FN precursor) 4504 9623 14714 0.9 1.OOE-104 AF231920.1 NT Homo sapiens chromosome 21 unknown mRNA 4504 9623 14715 0.9 1.OOE-104 AF231920.1 NT Homo sapiens chromosome 21 unknown mRNA 4735 9846 2.8 1.0OE-104 AW054828.1 EST-HUMAN ws60d04.xl NCII CGAF_Bm25 Homo saplens cDNA clone IMAGE:2501575 Y similar to TR:Q13541 Qll 4E.BINDING PROTEIN l.; 277 7859 10594 1.0 11.0OE-105 4502166 NT Homo saplens amylold beta (A4) precursor protein (protease nexin-I l, Alzheirner disease) (APP), mRNA 419 5208 10309 5.7 11.0OE-105 4505150 NT Homo saplens Meisl (mouse) homolog (MEIS1) mRNA 1777 6898 12085 1.2 1.OOE-105 AL163280.2 NT Homo saplens chromosome 21 segment HS21 C080 1884 7002 12187 0.6 11.0OE-105 D509118.1 NT Human mRNA for KIAA0128 gene, partial cds 2142 7252 12460 0.6 1.OOE-105 J04977.11 NT Human Ku autolmmune antigen gene, complete ods 2689 7776 0.9 1.OOE-105 AA584808.1 EST HUMAN nolOdO5.sl NCI CGAP Phel Homo sapiens cONA. done IMAGE: 1100265 X 2975 8126 2.6 11.0OE-105 AJ229041.1 NT Homo sapiens 959 kb contig between AM1.1 and CBR1 on chromosome 21q22; segment 113 3307 8452 13564 0.9 1.OOE-105 7304922 NT Homo sapiens bromodomain adjacent to zinc finger domain, 2B (BAZ213), mRNA 3307 8452 13565 0.9 1.OOE-105 7304922 NT Homo sapiens bromodomain adjacent to 7Jnc finger domain, 2B (BAZ213), mRNA 4008 9139 14221 2.2 1.0OE-105 AW961688.1 EST HUMAN EST373761 MAGE resequendes, MAGG Homo sapiens cDNA 4855 9962 3.7 1.0OE-105 AL163208.2 NT Homo saple s chromosome 21 segment HS21 C008 5044 10144 15222 1.0 1.OOE-105 A13018339.1 NT Homo sapiens mRNA for KIAA0796 protein, partial cds 5095 10193 15272 2.2 1.OOE-105 A13020673.11 NT Homo sapiens mRNA for KIAA0866 protein, complete cds 5161 10144 15222 1.3 1.OOE-105 A13018339.1 NT Homo saplens mRNA for KIAA0796 protein, partial ods 5341 1.0 1.OOE-106 AW503208.1 EST-HUMAN Ul-HF-BNO-akt-9-07-0-Ul.rl N1H MGC 50 Horno, saplens cDNA done IMAGE:3078348 5' 198 5392 10519 0.5 1.OOE-106 A1565065.1 EST-HUMAN tg79c011.xl NCI_CGAP Utl Homo sapiens cDNA clone IMAGE:2215008 3' 212 5405 10529 0.9 11.0OE-106 8922990 NT Homo sapiens hypothetical protein FU1 1316 (FU1 1316), mRNA 533 1 5695 10818 0.6 1.OOE-106 AW965556.1 EST HUMAN EST377629 MAGE resequences, MAGI Homo sapiens cDNA 589 5749 10866 0.8 1.0OE-106 J00156 NT ___ Human lhydrofolate reductase pseudogene (psi-hdl) Page 151 of 196 Table 4

* Page 152 of 196 590 5749 10866 1.2 1.OOE-106 J00146.1 NT Human dihydrofolate reductase pseudogene (psi-hdl) 1508 6635 11804 1.0 1.OOE-106 AF145712.1 NT Homo sapiens soluble neuropilin-1 mRNA, complete cds 1674 6798 11976 1.6 1.OOE-106 U48724.1 NT Human epidermal growth factor receptor (EGFIR) precursor-mRNA, exon 4, partial cds 1762 6883 12065. 1.9 1.OOE-106 AA527446.1 EST HUMAN ng41c05.sl NCLCGAF_Co3 Homo saplens cDNA cJone IMAGE:937352 Ysimilar to contains element LTR3 repetitive element; 1762 6883 12066 1.9 1.OOE-106 AA527446.1 EST-HUMAN n941 c05.sl NCLCGAP_Co3 Homo sapiens.cDNA clone IMAGE:937352 3' similar to contains element LTR3 repetitive element; 2075 7187 12390 1.1 1.OOE-106 BE144286.1 EST-HUMAN MRO-HT0165-140200-008- d10 HT0165 Homo saplens cDNA 2269 7375 12584 3.0 1.OOE-106 4504184 NT Homo saplens glutathione S- fransferase theta 1 (GSTT1), mRNA 2456 7555 12761 0.6 1.0OE-106 AF003528.1 NT Homo sapiens X-linked anhidroific ectodermal dysplasia protein gene (EDA), exon 2 and flanking repeat regions 2557 7651 12854 1.3 1.OOE-106 U64675.2 NT ns sperm membrane protein BS-63 mRNA, complete cds 2559 7653 12856 0.7 1.OOE-106 BE313721.1 EST-HUMAN 601149352F1 N1H MGC 19 Homo sapiens cDNA clone IMAGE:3502117 5' 2729 7813 13019 1.5 1.OOE-106 A1276526.1 EST HUMAN g176h10.xl Soares NhirIMPu_S1 Homo sapiens cDNA cJone IMAGE:1878307 3' 2795 6541 11715 1.1 1.OOE-106 4504184 NT Homo saplens glutathione Stransferase theta 1 (GSTT1), mRNA 2795 6541 11716 1.1 1.OOE-106 4504184 NT Homo saplens glutathione S- transferase theta 1 (GSTT1), mRNA 2911 8061 13167 5.0 1.OOE-106 AB037747.1 NT Homo saplens mRNA for KIAA1326 protein, partial cels 2911 8061 13168 5.0 1.OOE-106 AB037747.1 NT Homo sapiens mRNA for KIAA1326 protein, partial cds 3143 8292 13399 2.4 1.OOE-106 8922965 NT Homo sapiens hypothetical protein FW1 1273 (FL,11 1273), mRNA 3143 8292 13400 2.4 1.OOE-106 8922965 NT Homo saplens hypothetical protein FLA 1273 (FLJ1 1273), mRNA 3328 8472 13585 0.8 1.OOE-106 ABOO8681.1 NT Homo sapiens gene for activin receptor type 1JB, complete ods 3350 8494 13605 3.0 1.OOE-106 AW503073,1 EST HUMAN Ul-HF-BPOp-aje-h-06-0- Ul.rl NIM_MGC_51 Homo saplens cDNA clone IMAGE:3074170 5' 3394 8536 13641 1.0 1.0012-106 AB033104.1 NT Homo sapiens mIRNA. for KIAA1278 protein, partial ods 3394 8536 13642 1.0 1.OOE-106 A13033104.1 NT Homo sapiens mRNA for KIAA1278 protein, partial ods 3840 8976 14076 1.8 1.OOE-106 BE145043.1 EST HUMAN PM4-HT01 91-281099-002- d06 HTOI 91 Homo sapiens cDNA 3952 9085 14166 7.2 1.OOE-106 AW974650.1 EST HUMAN EST386875 MAGE resequences, MAGN Homo sapiens cDNA 3952 9085 14167 7.2 1.OOE-106 AW974650.1 EST HUMAN EST386875 MAGE resequences, MAGN Homo sapiens cDNA 4497 9617 14708 1.2 1.OOE-106 BE144286.1 EST HUMAN MRO-HT0165-140200-008- d10 HT0165 Horno sapiens ONA.

5183 10275 1.2 1.0OE-106 141644.1 NT Homo saplens dystrophin gene, exon 41 222 5414 10535 0.5 1.OOE-107 4506454 NT Homo sapiens redculocalbin 1, EFhand calcium binding domain (RCN 1), mRNA 234 5425 1.2 1.OOE-107 AJ271735.1 NT Homo sapiens Xq pseudoautosomal region; segment 112 264 5451 1.1 1.OOE-107 X60459.1 NT Human IFNAR gene for interferon - alphalbeta receptor 606 5764 1.1 1.0OE-107 4826863 NT Homo sapiens neuronal cell adhesion molecule (NIRCAM) mRNA 614 5772 10893 0.6 1.OOE-107 AF155103.1 NT Homo sapiens NY-REN-25 antigen mRNA, partial ods 796 5947 11097 0.9 1.OOE-107 X60459.1 NT Human WNAR gene for Interferon alphalbeta receptor 868 6016 11176 1.2 1.OOE-107 X60459.1 NT Human WNAR gene for interferon alphalbeta receptor 953 6099 1 OOE-107 AF154121.1 NT Homo sapiens sodium-dependent high- affinity dicarboxylate transporter (NADC3) mRNA, complete cds 1257 6386 11547 0.8 1.OOE-107 AB032253.1 NT Homo saplens BAZ1 B mRNA for bromodomain adjacent to zinc finger domain 1 B, complete cds Table 4

1718 6841 12020 0.5 1.OOE-107 AF136275.1 NT Homo saplens cathepsin precursor (CTSZ) gene, exon 3 1797 6917 12103 1.0 1.OOE-107 AB007922.2 NT Homo saplens mRNA for KIAA0453 protein, pardal cds 1797 6917 12104 1.0 1.OOE-107 ABOO7922.2, NT Horno saplens mRNA for KI1AA0453 protein, pardal cds 2161 7270 12481 1.3 1.OOE-107 U113729.1 NT Human dipepfido pepfidase IV (CD26) gene, egon 20 2487 7584 12789 0.9 1.OOE-107 4759153 NT Homo sapiens synaptosomakassodated protein, 29k1D (SNAP29) mIRNA 2487 7584 12790 0.9 1.OOE-107 4759153 NT Homo sapiens synaptosomakassodated protein, 29k1II) (SNAP29) mRNA 2976 8127 13233 1.9 1.OOE-107 AW842451.1 EST-HUMAN PM1-CN0031-190100-001- d03 CN0031 Homo sapiens cIDNA 2976 8127 13234 1.9 1.0OE-107 AW842451.1 EST-HUMAN PMI-CN0031-190100-001- d03 CN0031 Horno saplens cIDNA 3061 8212 13311 2.6 1.OOE-107 5902097 NT Honno sapiens SMT3 (suppressor of mif two 3, Least) homolog 2 (SMT3H2), mRNA 3754 8892 13982 3.9 1.OOE-107 AF020671.1 NT Homo sapiens myotubularin (MTM1) gene, exon 9 939 6086 11243 1.5 1.OOE-108 SE296042.1 EST-HUMAN 601177018F1 NIH.MGC 17 Homo saplens cIDNA clone IMAGE:3532348 S' 1244 6373 11531 0.5 1.OOE-108 Y18000.1 NT Homo saplens NF2 gene 2012 7126 0.7 1.OOE-108 AiO89548.1 EST-HUMAN qJJ06102.xl Soares_pregnant- uterus_NbHPU Homo saplens cDNA clone IMAGE: 1 69W3 3, 2282 7368 12595 2.7 1.OOE-108 AF1138303.1 NT Homo saplens decorin D mRNA, complete cds, alternalively spliced 2282 7388 12596 2.7 1.OOE-108 AF138303.1 NT Homo saplens decorin D mRNA, complete cds, altematively spliced 2378 7480 12682 2.6 1.OOE-108 BE206694.1 EST_HUMAN Ibb25b10.xl NIH-MGC-14 Homo saptens cDNA clone IMAGE:2963899 Ysirnflar to gb:X53777 60S RIBOSOMAL PROTEIN L23 (HUMAN); gb:J05277 Mouse hexokinase mRNA, complete cds (MOUSE); 3158 8307 13417 1.9 1.OOE-108 4506354 NT Homo sapiens pregnancy-zone protein (PZP) mRNA 3158 8307 13418 1.9 1.0OE-108 4506354 NT Homo sapiens pregnancy-zone protelnjPZP) mRNA 3742 8879 13969 0.9 1.0OE-108 5453855 NT Homo sapiens pericentdolar material 1 (PCM1) mIRNA 4065 9192 14276 1.3 1.0OE-108 AW664438.1 EST-HUMAN h112al 1.xl NCI..PGAP. GU1 Homo saplens cDNA done IMAGE:2972060 3'similar to SW:313P11-MOUSE P55194 SH3-BINDING PROTEIN 3BP-l.; 4425 9546 14638 2.0 1.0OE-108 U72961.1 NT Human hepatocyte nuclear factor 4-alpha gene, exon 2 4425 9546 14639 2.0 1.OOE-108 U72961.1 NT Human hepatocyte nuclear factor 4-alpha gene, exon 2 4555 9673 14764 2.1 1.0OE-108 AA186965.1 EST- HUMAN zp66f01.rl Stratagene endothelial cell 937223 Homo saplens cDNA done IMAGE:625177 5 4699 9F1 11 14908 2.9 1.OOE-108 7661979 NT Homo sapiens KIAA0187 gene product (K1AA0187), mRNA 4868 9975 15060 2.2 1.OOE-108 AJ008005.1 NT Honno saplens PSW gene, alternative transcript 58 5266 10388 0.9 1.0OE-109 D86974.1 NT Human mRNA for KIAA0220 gene, pardal cds 459 5625 10751 1.2 1.OOE-109 4507712 NT Homo sapiens tetratricopepfide repeat domain 2 (TTC2) mIRNA 583 5743 10860 5.0 1.OOE-109 AB023216.1 NT Homo saplens mIRNA for KIAA0999 protein, partial cds 583 5743 10861 5.0 1.OOE-109 AB023216.1 NT Homo sapiens mIRNA for KIAA0999 protein, partial ods 1184 6317 11473 3.3 1.OOE-109 M28699.11 NT Homo sapiens nudeolar phosphoprotein B23 (NPM11) mRNA, complete ods 1185 631 11473 1.7 1.0OE-109 M28699.1 NT Honno sapiens nudeolar phosphoprotein B23 (NPMI) mIRNA, complete cds 1831 6950 12134 0.5 1.OOE-109 D13643.2 NT Homoapiens mIRNA for KIAA001 8 protein, pardal cds 2194 7353 12517 0.7 1.OOE-109 AL16328M4. NT Homo sapiens chromosome 21 segment HS21C084 2204 7313 12525 0,7 1.0OE-109 Y17123.1 NT Homo sapiens SNF51INI I gene, exon 6 7674 12876 1.4 1.OOE-109 A1022328.1 EST HUMAN ow95a01.xl SoareE_fetaUlver- spleerk_l NIFILS-SI Homo sapiens cDNA clone IMAGE:1654536 Ysimilar to TR:002197 002197 CIRCULATING CATHODIC ANTIGEN.; C.r d c Page 153 of 196 Table 4

2581 7674 12877 1.4 1.OOE-109 A1022328.1 EST HUMAN ow95a01.xl Soaresfetal-liveLspleen_l NFLS-Sl Homo sapiens cDNA clone IMAGE:1654536 X similar to TR:002197 002197 CIRCULATING CATHODIC ANTIGEN. ', 2582 7675 12878 1.0 1.OOE-109 4504206 NT Horno sapiens quanylate cyclase activator 1A (retina) (GUCA1A) mRNA 2907 8057 13162 1.3 1.OOE-109 BE243668.1 EST HUMAN TCBAP1D1367 Pediatric pre-B cell. acute lymphoblastic leukernia Baylor-HGSC project=TCBA Homo sapiens cDNA done TCBAP1367 2907 8057 13163 1.3 1.OOE-109 BE243668.1 EST HUMAN TCBAP1D1367 Pediatric pre-B call acute lymphoblastic leukemia Baylor-HGSC project=TCBA Homo sapiens cDNA done TCBAP1367 3020 8172 13272 1.9 1.OOE-109 N85190.1 EST-HUMAN J2816F Human fetal heart, Lambda ZAP Express Homo sapiens cDNA clone J2816 W similar to ZINC FINGER PROTEIN ZNF43 3342 8486 13600 1.5 1.OOE-109 AW893192.1 EST-HUMAN CM3-NNO009-190400-150- flO NNO009 Homo saplens cDNA 3342 8486 13601 1.5 1.OOE-109 AW893192.1 EST-HUMAN C1V13-NN0009-11 90400- 150-fl 0 NNO009 Homo sapiens cDNA 3474 8615 13727 1,2 1.0OE-109 AF240698.1 NT Homo saplens retinol dehydrogenase homolog Isoform-1 (RDH) mRNA, complete ods 3767 8905 1.5 1.OOE-109 BE146144.1 EST HUMAN MRO-HT0209-110400-108-a04 HT0209 Homo sapiens cDNA 3911 9046 14133 1.5 1.0OE-109 AB01 1181,2 NT Homo sapiens mRNA for KIAA0609 protein, Partial cds 3911 9046 14134 1.5 1.OOE-109 AB011181.2 NT Horno sapiens mRNA for KIAA0609 protein, partial cds 4054 9181 14264 3.7 1.OOE-109 A1655417.1 EST HUMAN ts98e06.xl NCLWAP-GC6 Homo sapiens cDNA done IMAGE:2239330 Ysimilar to WP:F53A2.8 CE161100; 4070 9197 14281 1.0 1.OOE-109 AA662274.1 EST-HUMAN nu93c12.sl NCI - CGAP Pr22 Horno saplens cDNA done IMAGE:1218262 Ysimilar to SW:WT2 HUIAN P3C712 GLUTHATHIONE S-TRANSFERASE THETA 2; 4070 9197 14282 1.0 1.OOE-109 AA662274.1 EST HUMAN nu93c12.sl NCLWAP Pr22 Horno sapiens cDNA done IMAGE:1218262 Ysimilar to SW:WT2 HUMAN P3j712 GLUTHATHIONE S-TRANSFERASE THETA 2 4304 9458 14518 2.3 1.0OE-109 4504206 NT Homo saplens quanylate cyclase activator 1A (retina) (GUCA1A) mRNA 4496 9616 14707 1.2 1.OOE-109 7662083 NT Horno sapiens KIAA0377 gene product (K1AA0377), mRNA 4839 9946 15035 1.0 1.00FE-109 R15400.1 EST HUMAN ya48e06xl Soares infant brain 1 NIB Homo sapiens cDNA clone IMAGE:53057 5' 4984 10087 15158 0.9 1.OOE-109 BE293673.1 ESTHUMAN 601186922F2 NIH_MGC 15 Homo saplens cDNA clone IMAGE:2959636 5' 4984 10087 15159 0.9 1.0OE-109 BE293673.1 EST HUMAN 601186922F2 NIFI MGC 15 Homo sapiens cDNA done IMAGE:2959636 S' 3 5212 10313 0.5 1.OOE-110 7549804 NT Homo sapiens delodinase, lodothyronine, type 11 (D102), transcript variant 2, mRNA 34 5243 10349 1.3 1.0OE-11 10 5803073 NT Horno sapiens leudne-zipper-like transcriptional regulator, 1 (LZTRI1), mRNA 34 5243 10350 1.3 1.OOE-110 5803073 NT Horno sapiens leudne-zipper-like transcriptional regulator, 1 (LZTRI1), mRNA 5281 10408 10.0 1.OOE-110 C04498.11. EST-HUMAN C04498 Human heart cDNA (YNakamura) Homo sapiens cDNA done 3NHC3467 104 5212 10313 0.6 1.OOE-110 7549804 NT Homo sapiens delodinase, lodothyronine, type 11 (D102), transcript va ant 2, mRNA 291 5477 10608 0.9 1.OOE-110 D87291.1 NT Human mRNA for inward rectifier potassium channel, complete cds 516 5680 10801 1.2 1.OOE-1 70 U84550.11 NT Human dystrobrevin (DTN)ene, exon 20 1163 6298 11453 1.1 1.OOE-110 5031620 NT Horno sapiens caldtonin receptorlike (CALCRIL) mRNA 1258 6387 11548 1.0 1.0OE-110 AB032253.1 NT Homo sapiens BAZ1 B mRNA for bromodomain adjacent to zinc finger domain 1 B, complete cds 1879 6997 12182 0.5 1.OOE-110 BE379477,1 EST-HUMAN 601237545F1 NIFI MGC 44 Homo saplens cDNA done IMAGE:3609683 5' 2810 7961 1.0 1.OOE-110 4503098 NT Horno sapiens chondroifin sulfate proteoglycan 4 (melanoma-assocJiated) (CSPG4), mRNA 3048 8199 1.1 1.OOE-110 U78027.1 NT Homo saplens Bruton's tyrosine kinase (BTK), alpha-D-galactosidase A (GLA), L44-like dbosomal protein (1.441---)and FTP3 (FTP3) genes, complete cds It ir r Page 154 of 196 Table 4

3966 9098 14182 0,9 1.0OE-110 BE018556.1 EST-HUMAN bb82a05.Y1 NiltMGQ-10 Horno sapiens cIDNA done iMAGE:3048848 5'similar to TR:060312 060312 KIAA0566 PROTEIN; 4533 9652 14739 2.1 1.OOE-110 A1017213.1 EST HUMAN ou32b10.xl Soares - NFL,:GBC-Sl Homo sapiens cDNA done IMAGE:1627963 3'similar to SW:W211---RATP52591 NUCLEAR ENVELOPE PORE MEMBRANE PROTEIN POM 121 4898 10005 2.3 1.OOE-110 7662441 NT Homo sapiens KIAA1002 protein (K1AA1002), mRNA 168 5362 5.7 1.OOE-1 11 U43701.1 NT Human dbosomal protein L23a mRNA, complete ods 189 5383 10510 1.0 1.0OE-1 11 4758807 NT Homo sapiens ras GTPase activating protein-like (NGAI) mRNA 726 5880 11021 1.2 1.00EA 11 8393092 NT Homo sapiens cat eye syndrome critical region gene 1 (CECR1), mRNA 911 6057 11216 25.0 1.00EA 11 M25142.1 NT Human cardiac alpha-myosin heavy chain (MYH6) gene, exons 32 to 34 1564 6691 11860 2.0 1.0OE-1 11 AA213434.1 EST-HUMAN zq93f12xl Stratagene hNT neuron (#937233) Homo saplens cDNA done IMAGE:649583 5' 1564 6. 691 11861 2,0 1.00EA 11 AA213434.1 EST HUMAN zq93f12xl Stratagene hNT neuron (#937233) Homo sapiens cDNA clone IMAGE:649583 5' 3642 8781 13874 1,2 1.0OE-1 11 6912641 NT Homo, sapiens sex comb on midleg homolog 1 (SCM1-11), mRNA 3642 8781 13875 1.2 1.00EA 11 6912641 NT Homo sapiens sex comb on midleg homolog 1 (SCMH1), mRNA 4080 9207 14292 1.1 1.00EA 11 7661569 NT Homo sapiens DKFZP434D156 protein (DKFZP434D156), mRNA 4235 9359 14441 4.5 1.0DE-1 11 K02268.1 NT Human enkephalin B (enkB) gene, exon 4 and Yflank and complete cds 592 5750 10867 0.9 1.00EA 12 4501854 NT Homo sapiens acetyl-Coenzyme A carboxylase beta (ACACB), mRNA 594 5752 10869 1.5 1.00EA 12 U29103.1 NT Human steroidogenic acute regulatory protein (StAR) gene, exon 5 594 5752 10870 1.5 1.0OE-1 12 U291103.1 NT Human steroldogenic acute regulato!y protein (StAR) gene, exon 5 985 6130 11285 1.0 1.OOE-112 AF157623.1 NT Homo sapiens HTRA sedne protease (PRSSI 1) gene, complete cds 1046 6186 11337 0.6 1.0OE-11 12 P52742 SWISSPROT ZINC FINGER PROTEIN135 1658 6782 11956 2,1 1.OOE-112 7662125 NT Homo sapiens KIAA0440 protein (K1AA0440), mRNA 1658 6782 11957 2.1 1.0OE-11 12 7662125 NT Horno sapiens KIAA0440 protein (K1AA0440), mRNA 2460 7559 12763 0.9 1.00EA 12 AF004713.1 NT Horno sapiens DNA-dependent DNA polyrnerase (hREV3) RNA, partial cds 3135 8284 13391 1.2 1.0OE-112 AF247662.1 NT Homo sapiens SR-related protein LD2 mRNA partial cds 3809 8W6 14042 0.8 1.00EA 12 BE076073.1 EST-HUMAN MR2-13T0590-090300- 113409 BT0590 Homo sapiens cDNA 4646 9759 14853 5.1 1.00EA 12 AB037832.1 NT Homo sapiens mRNA for KIAA1411 protein, partial cds 4646 9759 14854 5.1 1.OOE-112 AB037832.1 NT Homo sapiens mRNA for K1AA1 411 protein, partial ods 5170 10264 15336 0.9 1.00EA 12 9055269 NT Homo sapiens low density lipoprotein receptor related protein-deleted In tumor (LRPDIT), mRNA 725 5879 11019 1.3 1.00EA 13 A1365586.1 EST_HUMAN ao95f01.xl Schiller meningioma Homo saplens cDNA done IMAGE:1953625 3' 725 5879 11020 1.3 1.00EA 13 A1365586.1 EST-HUMAN ao95f01.xl Schiller meningloma Horno saplens cIDNA done IMAGE:1953625 31 927 6074 11232 2.2 1.00EA 13 M1 1965.1 NT Human X-linked phosphoglycerate kinase gene, exon 8 1523 6650 11818 1.1 1.0011-113 A1365586.1 EST-HUMAN ao95f01.xl Schiller meningloma Homo saplens cDNA done IMAGE:1953625 3' 2048 7161 12365 1.2 1.00EA 13 5453699 NT Homo saplens Interferon regulatory factor 6 (IRF6) mRNA 2405 7504 12711 1.0 1.OOE-113 AJ006976.1 NT Homo saplens PLP gene 3091 8242 13345 2.3 1.0OE-1 13 AJ223948.1 NT Homo sapiens mRNA for putative RNA helicase, 3' end 15209 1.0 1.00EA 13 7657065 NT Homo sapiens v-ets avian crythroblastosis virus E26 oncogene related (ERG), mRNA 10135 15210 1.0 1.00EA 13 7657065 NT - Homo sapiens v-ets avian orCrobtastosis virus E26 oncogene related (ERG), mRNA Page 155 of 196 Table 4

629 5788 10911 2.6 1.00EA 14 T70551.1 EST HUMAN yd15c01.51 Scares fetal liver spleen INFI.S Homosapiens cDNA done IMAGE:108288 3' similar to gb:A21187 ALPHA-2-MACROGLOBULIN PRECURSOR (HUMAN);contains Alu repetitive element; 1055 6194 11347 1.3 1.00EA 14 8923087 NT Homo sapiens hypothetical tein FLJ20080 (FLJ20080), mRNA 1291 6420 11585 1.2 1.00EA 14 7657529 NT Homo sapiens rhabdold tumor deletion region protein 1 (RTDR1), mRNA 1648 6774 11945 2.0 1.00EA 14 6679073 NT Homo sapiens nudeoporin-like protein 1 (NLP 1), mRNA 1980 7095 12297 1.2 1.00EA 14 BE165972.1 EST HUMAN MR3-HT0487-150200-116- d01 HT0487 Homo sapiens cDNA 2773 5247 10355 0.8 1.00EA 14 A13033102.1 NT Homo sapiens mRNA for KIAA1276 protein, partial cds 2773 5247 10356 0.8 1.OOE-114 A13033102.1 NT Homo sapiens mRNA for KIAA1276 protein, partial cds 3092 8243 13346 2.3 1.00EA 14 X04086.1 NT Human gene for catalase (EC 1, 11.1.6) exon 2 mapping to chromosome 11, band pl 3 3934 9068 14153 2.0 1.0OE-11 14 AF149773.1 NT Homo sapiens NOD1 protein (NOD1) gene, exons 1, 2, and 3 5120 10216 15294 1.2 1.00EA 14 AA194468.1 EST HUMAN zq05e05xl Stratagene musde 937209 Homo sapiens cDNA clone IMAGE:628832 5'similar to contains MER22.t21 MER22 repetitive element; 5121 10217 15295 2.3 1.00EA 14 AF004849.1. NT Horno sapiens PKY protein kinase mRNA, complete eds 21 5230 10333 1.2 1.0OE-11 15 4758111 NT Homo sapiens HLA-B associated transcript-11 (D6S81 E) mRNA 5321 10452 1.0 1.00EA 15 4505938 NT Homo sapiens polymerase (RNA) 11 (DNA directed) polypeptide A (220kD) (POLR2A) mRNA 129 5325 0.7 1.00EA 15 4557887 NT Horno sapiens keratin 18 (KRT18) mRNA 289 5475 10605 0.7 1.00EA 15 AW804759.1 EST HUMAN OV4-UM0094-300300-156- b08 UM0094 Horno sapiens cDNA 374 5550 10683 1.0 1.00EA 15 014867 SWISSPROT TRANSCRIPTION REGULATOR PROTEIN BACH1 (BTB AND CNC HOMOLOG 1) (HA2303) 525 5689 10810 1.1 1.00EA 15 A1339206.1 EST HUMAN qt06f011.xl NCl-WAP-GC4 Homo sapiens cDNA done IMAGE:1946809 3'similar to TR:000536 000536 TTF-1 INTERACTING PEPTIDE 5; 525 5689 10811 1.1 1.00EA 15 A1339206.1 EST-HUMAN qt06f01.xl NCI CGAP_GC4 Homo sapiens cDNA clone IMAGE:1946809 Ysimilar to 769 5921 11069 0.6 1.00EA 15 5174702 NT TR:000536 0j0536 TTF-1 INTERACTING PEPTIDE 5; Homo sapiens transforming growth factor beta-actvated kinase-binding protein 1 (TAB1), mRNA 769 5921 11070 0.6 1.00EA 15 5174702 NT Homo sapiens transforming growth factor beta-activated kinase-binding protein 1 (TAB1), mRNA 771 5923 11072 17,0 1.OOE-115 4503794 NT Homo sapiens ferritin, heavy polypepfide 1 (FTH1) mRNA 1539 6665 11833 0.9 1.00EA 15 AF229180.1 NT Horno sapiens alpha- aminoadipate semialdehyde synthase mRNA, complete cds 1539 6665 11834 0.9 1.OOE-115 AF229180.1 NT Homo sapiens alphaaminoadipate sernialdehyde synthase mRNA, complete cds 1785 6905 12093 1,1 1.00EA 15 AJ277892.1 NT Homo sapiens partial TTN gene for Edn 1798 6918 12105 0.5 1.00EA 15 U78027.1 NT Homo sapiens Bruton's tyrosine kinase (BTK), alpha-D-galactosidase A (GLA), L44-like dbosomal protein (L441---)and FTP3 (FTP3) genes, complete cds 2034 7147 12349 0.9 1.00EA 15 BE296353.1 EST HUMAN 601174384F1 N1H MGC 17 Homo sapiens cDNA done IMAGE:3529773 5, 2034 7147 12350 0.9 1.0OE-11 15 BE296353.1 EST-HUMAN 601174384F1 NIH MGC 17 orno sapiens cDNA done IMAGE:3529773 5' 2704 7878 12990 0.8 1.0OE-11 15 475811_1 NT Homo sapiens HLA-B associated transcdpt-1 (D6S81 E) mIRNA 2820 7971 1.8 1.00EA 15 AW804759.1 EST HUMAN QV4-UM0094-300300-156-b08 UM0094 Homo sapiens cIDNA 3077 8228 13327 2.1 1.00EA 15 AJ245922.1 NT Homo sapi ns mIRNA for alpha- tubulin 8 (TUBA8 gene) 8228 13328 2.1 11.0OE-1 15 AJ245922.1 NT Homo sapiens mRNA for alpha- tubulin 8 (TUBA8 gene) Page 156 of 196 Table 4

3427 8569 13681 4.0 1.0OE-11 15 AJ277892.1 NT Horno sapiens partial TTN gene for titin 3956 9089 14172 4.0 1.00EA 15 A13002348.2 NT Homo saplens mRNA for KIAA0350 protein, partial ods 4169 9295 14376 1.1 1.00EA 15 AL1 37163.1 NT Novel human gene mapping to chomosome X 4301 9425 14515 3.4 1.0OE-1 15 6912659 NT Homo saplens sir2-like 3 (SIRT3), mRNA 4335 9458 14546 3.8 1.00EA 15 4758279 NT Homo sapiens EphA4 (EPHA4) mRNA 4578 9694 14766 2.6 1.00EA 15 AL.096857.1 NT Novel human mRNA from chromosome 1, whichtas similarities to BAT2 genes 4578 9694 14787 2.6 1.OOE-115 AL096857.1 NT Novel human mRNA from chromosome 1, whIch'has similarities to BAT2 genes 4813 9922 15014 3.0 1.00EA 15 AL163268.2. NT Homo saplens chromosome 21 segment HS21 C068 4813 9922 15015 3.0 1.0OE-1 15 AL.163268.2 NT Homo saplens chromosome 21 segment HS21 C068 560 5722 10838 1.4 1.00EA 16 BE275502.1 EST_HUMAN 601121347F1 NIH MGQ_20 Homo saplens cDNA done IMAGE:2988875 5' 783 5935 11084 1.3 1.00EA 16 4507334 NT Homo sapiens synaptojanin 1 (SYNJ1), mRNA 841 5990 6.9 1.00EA 16 4507334 NT Horno saplens synaptojanin 1 (SYNJ1), mRNA 1952 7069 12265 0.9 1.OOE-1 16 5174478 NT Homo sapiens pericentrin (PCNT) mRNA 1952 7069 12266 0.9 1.00EA 16 5174478 NT Homo saplens pericentrin (PCNT) mRNA 2050 7933 12366 1.0 1.00EA 16 M19824.1 NT Human apolipoprotein 8-100 (apoB) gene, exons 17 and 18 2050 7933 12367 1.0 1.OOE-116 M191324.1 NT Human apollpoproteln B-100 (aRoB) gene, exons 17 and 18 2259 7365 12574 0.7 1.OOE-1 16 5453941 NT Homo saplens protein phosphatase,'EF hand calcium-binding domain 1 (PPEF1) mRNA 2293 7397 0.5 1.0012-116 U78308.1 NT Human olfactory receptor olfr17-201- 1 (OR17-201-1) gene, olfactory receptor olfr17-32 (OR17 32) gene and olfactory receptor pseudo_olfrl7-01 (OR17-01) pseudogene, complete ods 2407 7506 12713 1.6 1.OOE-116 AB0118333.1 NT Homo sapiens mRNA for KIAA0790 protein, partial cds 3137 8286 13392 4.7 1.0OE-1 16 L77570.1 NT Homo saplens DIGeorge syndrome critical region, centromeric end 3137 8286 13393 4.7 1.00EA 16 L77570.1 NT Homo saplens DIGeorge syndrome critical region, centromedc end 4281 9406 14490 2.0 1.00EA 16 5031954 NT Horno saplens sodium phosehate transporter 3 (NPT3) mRNA 4747 9858 14950 2.2 1.0OE-1 16 A1907096.1 ES-_HU N PM-BT135-070499-016 BT135 Homo sapiens cDNA 5122 10218 15296 1.2 1.00EA 16 AJ243213.1 NT Homo saplens partial 5-HT4 receptor gene, exons 2 to 5 267 5454 10579 1.4 1.00EA 17 4507500 NT Homo, sapiens T-cell lymphoma invasion and metastasis 1 MAM1) mRNA 546 5709 10828 1.2 1.0OE-1 17 4826636 NT Homo sapiens acetyl-Coenzyme A carboxyase alpha (ACACA), mRNA 1061 7906 11353 0.5 1.00EA 17 AF124393.1 NT Mus musculus fragile.X- telated protein 1 (Fxrl h) gene, exons 13a through 15 1719 6842 12021 6.3 1.00EA 17 AF123320.1 NT Homo sapiens lymphocyte activation-assoclated protein mRNA, complete ods 1772 6893 12081 2.1 1.00EA 17 H26662.11 EST_HUMAN y114d0S.sl Soares breast 2NbHBst Horno saplens eDNA done IMAGE:158217 X similar to gbWO9850 ZINC FINGER PROTEIN 76 (HUMAN); 1790 6910 12096 0.8 1.00EA 17 M19816.11 NT Human apolipoproteln B-100 (apoB) gene, exon 10 216.4 7273 12484 1.1 1.OOE-117 AW957699.1 EST - HUMAN EST369769 MAGE resequences, MAGE Horno saplens cDNA 3230 8378 13485 1.8 1.00EA 17 AA978114.1 EST HUMAN op32c1I.si Soares_NFLj_GBC S1 Homo sapiens cDNA done IMAGE:15785483' 3908 9043 14131 3.6 1.0OE-1 17 AA316723.1 EST-HUMAN EST188414 HCC cell line (matastasis to liver in mouse) 11 Horno sapiens cDNA 5' end similar to ribosomal protein L29 4247 9372 14452 1.9 1.00EA 17 8659564 NT Homo saplens collagen, type IV, alpha 5 (Alport syndrome) COL4A5), mIRNA 4475 9595 14690 1.9 1.00EA 17 AL042120.1 EST HUMAN DKFZp434C1 120-rl 434 (synonym: htes3) Homo sapiens cDNA done DKFZp434C1 120 5' 4622 9736 14831 1.4 1.00EA 17 X89670.1 NT H.sapiens mRNA for TPCR16 protein 1 j C) Page 157 of 196 Table 4

4622 9736 14832 1,4 11.0OE-1 17 X89670.11 NT H.sapiens mRNA for TIPC1R1 6 protein 4705 9817 14914 9.2 1.0OE-11 17 AF134304.2 NT Homo sapiens Scar2 (SCAR2) gene, partial cds 4705 9817 14915 9.2 1.OOE-117 AF134304.2 NT Horno saplens Scar2 (SCAR2) gene, partial ods 4856 9963 15048 3.4 11.0OE-11 17 AB020673.11 NT Homo sapiens mRNA for KIAA0866 protein, complete cds 64 5272 10395 3.3 1.OOE-118 AF161500.1 NT Homo sapiens HSPC151 mRNA, complete eds 5296 10422 0.9 11.0OE-118 AL045854.1 EST HUMAN DKFZp4341056 r11 434 ( ynonym: htes3) Homo sapiens cDNA done DKFZp4341056 5' 355 5534 10664 0.5 1.OOE-1 18 4507500 NT Homo saplens T-cell lymphoma invasion and metastasis 1 (TIAM1) mRNA 506 5670 10793 1.7 1.OOE-1 18 7657016 NT Homc, saplens hypothetical protein (DJ328E19.CII.1), mRNA 896 7902 11199 1.0 1.0OE-11 18 5174680 NT Homo saplens sine oculls homeobox (Drosophila) hornolog 1 (SIX1) mRNA 2186 7295 12507 0.9 1.OOE-118 BE389705.1 EST HUMAN 601281947F1 NIH_MW 44 Horno saplens cDNA clone IMAGE:3604019 5' 2186 7295 12508 0,9 11.0OE-11 18 BE389705.1 EST HUMAN 601281947F1 NI G 44 Horno saplens cDNA done IMAGE:3604019 5, 2186 7295 12509 0.9 1.00EA 18 BE389705.11 EST HUMAN 601281947F1 N1H MGC 44 Homo sapiens cDNA cJone IMAGE:3604019 5' 2281 7387 1.4 1.0012-118 AW951729.1 ESTHUMAN EST363799 MAGE resequences, MAGB Homo sapiens cDNA 2711 7796 12997 0.9 11.0012-118 U07000.1 NT Human breakpoint cJuster region (BCR) gene, complete cds 2711 7796 12998 0.9 1.OOE-1 18 U07000.1 NT Human breakpoint duster region (BCR) gene, complete cds 3066 8217 3.7 1.OOE-118 Y113932.1 NT Homo sapiens PRKY exon 3159 8308 13419 4.5 11.0OE-1118 A1347694.1 EST HUMAN qpOlfOS.xl NCI_WAP KidS Horno sapiens cDNA done IMAGE:1916769 X 3159 8308 13420 4.5 1.OOE-118 A1347694.1 EST HUMAN qpOlfO5.xl NCI CGAP Kid5 Homo saple s cDNA clone IMAGE:1916769 3, 3998 9129 14211 7.7 1.00EA 18 D23660.11 NT Human mRNA for ribosomal protein, corn lete ods 741 5894 11040 0.8 1.0OE-1119 AF1170492.1 NT Homo saplens chloride channel CLC4 (C1C4) mRNA, complete cds 1021 7905 11313 0.5 1.OOE-119 7705607 NT HomosapiensCGI-10 protein (LOC51011), ffiRNA 1891 7008 12195 0.8 1.OOE-119 AB0231147.1 NT Homosapi nsmRNAforKlAA0930pro In,partialcds 3054 8215 13315 1.8 1.0012-119 8922205 NT Homc, sapiens hypothetical protein FLJ10052 (FLJ10052), mRNA 3202 8350 1.1 1.OOE-119 AA916760.1 EST HUMAN onlObO5.sl NCl-WAP-Lu5 Homo sapiens cDNA clone IMAGE:1556241 3'similar to WRE04F6.2 CE01214; 3870 9006 14105 1,2 1.OOE-119 4504116 NT Horno, sapiens glutamate receptor, lonotroplc, kainate 1 (GRIM) mIRNA 5111 10207 15285 1.0 11.0OE-119 AA077394.1 EST-HUMAN 7B14F03 Chromosome 7 Fetal Brain cDNA Library Homo sapiens cDNA clone 7BI4F03 237 5427 10554 1.4 1.OOE-120 AB018301.1 NT Homo sapi ns mRNA for KIAA0758 protein, partial ods 298 5484 10614 1,3 1.0OE-120 4507334 NT Homo saplens synaptojanin 1 (SYNA), mRNA 1025 6165 11319 0.6 1.OOE-120 AF248540.1 NT Homo saplens Intersectin 2 (SH3DII B) mRNA, complete ods 1025 6165 11320 0.6 11.0OE-120 AF248540.1 NT Horno sapiens intersectin 2 (SH3DII B) mRNA, complete ods 1406 6533 11704 1.6 1.0OE-120 N44873.1 EST HUMAN yy40912.rl Scares melanocyte 2NbHM Horno sapiens cDNA clone IMAGE:273766 5' 1583 6709 11880 1.4 1.OOE-120 AF1167706.1 NT Homo sapiens cystelne-rich repeat-containing protein S52 precursor, mRNA, complete cds 1684 6808 11990 0.7 1.0OE-1120 5729777 NT Homo sapiens collagen, type YJ1, alpha 1 (COL12A1), mRNA 1684 6808 11991 0.7 1.OOE-120 5729777 NT Homo sapiens collagen, type X11, alpha 1 (COL12A1), mRNA 2060 7172 12379 0.9 1.0012-120 5174574 NT Homo saplens myeloldllymphold or mixed-lineage leukernia (trithorax (Drosophila) hornolog); 2060 7172 12380 0.9 1.OOE-120 5174574 NT translocated to, 4 (MI-LT4) mRNA Homo sapiens myelolcinymphoid or mixed-lineage leukernia (trithorax (Drosophila) homolog); translocated to, 4 (MI-LT4) mIRNA 2482 7580 12782 0.8 1.00E.120 4755124 NT Homo sapiens aquaporin 4 (AQP4), splice variant b, mRNA Page 158 of 196 Table 4

3267 5484 10614 1.1 1.0OE-120 4507334 NT Homo sapiens synaptojanin 1 (SYNA), mRNA 4260 9385 14468 1,2 1.OOE-120 AF05649Y1 NT Homo sapiens cAMP-spedfic phosphodlesterase 8A (PIDEBA) mRNA, partial cds 4260 9385 14469 1.2 1.0OE-120 AF056490.1 NT Homo sapiens cAMP-specific phosphodiesterase 8A (PDE8A) mRNA, partial cds 4543 9662 14752 1.2 1.OOE-120 AW378049.1 ESTHUMAN MRO-HT0209-301 199-101- d04 HT0209 Homcsoplons cDNA 4563 9681 14774 2.8 11.0OE-120 AF098463.1 NT Homo saplens stanniocaldn (STC) gene, partial ods 4563 9681 14775 2.8 1.OOE-120 AF098463.1 NT Homo sapiens stanniocaldn (STC) gene. partial ods 5168 10262 15333 0.9 1.OOE-120 A11190903.1 EST-HUMAN qd61f03.xl Soares testis NHT Homo sapiens cIDNA done IMAGE:1733981 3' 67 5274 10399 1.0 11.0OE-121 Y18000.11 NT Homo saplens NF2 gene.

707 7896 10997 1.2 1.0OE-121 5032192 NT Homo saplens TINIF receptorassociated factor 1 (TRAF1) mRNA 1556 6683 11851 1.0 1.OOE-121 AB01 1153,1 NT Homo sapiens mIRNA for KIAA0581 protein, partial ods 1923 7040 12229 0.9 1.OOE-121 4755139 NT Homo saplens Inositol polyphosphate-4-phosphatase, type 1, 107k1D (INPP4A), splice variant a, mRNA 1923 7040 12230 0.9 1.OOE-121 4755139 NT Homo sapiens inosital polyphosphate-4-phosphatase, type), IORD (INPP4A), splice variant a, mRNA 2055 7167 12373 1.2 1.OOE-121 6006005 NT Homo saplens glutamate receptor, metabotropic 1 (GRM1) mRNA 3042 8193 13295 3.1 1.OOE-121 Y19208.1 NT Homosaplens hHb3 g" for hair keratin, exons 1 to 9 3042 8193 13296 3.1 11.0OE-121 Y1 9208.1 NT Horno saplens hi-1153 gene for hair keratin, exons 1 to 9 3492 8633 13745 1.1 1.OOE-121 A13037758.1 NT Homo saplens mRNA for K1AA11 337 protein, partial cds 3492 8633 13746 1.1 1.OOE-121 A13037758.1 NT Homo sapiens mRNA for KIAA1337 protein, partial ods 3624 8763 13857 6.6 1.0OE-11211 AF155156.2 NT Homo sapiens adaptor- related protein complex AP-4 epsilon subunit mRNA, complete cds 4236 9360 14442 1.2 1.0OE-121 A1263294.1 EST-HUMAN Qx57b011.xINCII. GAPPanIHomosapienscDNAcJonelMAGE:20054173' 4565 9683 14777 5.5 1.OOE-121 4506118 NT Homo saplens prospero-related homeobox 1 (PROX1) mIRNA 4901 10008 15088 2.6 1.0OE-1121 X911937.11 NT H.saplens ECE-1 gene (exon 17) 5050 10150 15227 1.0 11.0OE-1211 A1904151.1 EST_HILIMAN CM-BT043-090299075 BT043 Homo sapiens cONA 333 5514 10639 0.8 11.0OE-122 AFI 14488.1 NT Homo saplens Intersectin short isoform (ITSN) mRNA, complete cds 864 6012 11173 1.0 11.0OE-122 AF1 14488,1 NT Homo sapiens Intersectin short isoform (ITSN) mRNA, complete cds 1201 6333 11489 1.2 1.OOE-122 M20707.11 NT Human kappa-lmmunoglobulin germline pseudogene (Chr22.4) variable region (subgroup V kappa 11) 1667 6791 11967 1.3 1.OOE-122 AF167706.1 NT Homo saplens cystelne-rich repeat-containing protein S52 precursor, mRNA, complete cds 2441 7540 12747 3.8 1.0OE-1122 4506662 NT Homo sapiens dbosomal protein L8 (RPL8) mRNA 2441 7F40 12748 3.8 1.OOE-122 4506662 NT Homo sapiens ribosomal protein L8 (RPL8) mRNA 4738 9849 14941 1.8 11.0OE-122 4502166 NT Homo sapiens arnylold beta (A4) precursor protein (protease nexin-ii, Aizheimer disease) (APP), mRNA 4918 10025 1.2 11.0OE-122 AW504WA EST-HUMAN Ul-HF-BNO-all-a-03-0-Ul.rl NIM_WCL50 Homo sapiens cDNA clone IMAGE:3079948 5' 181 5375 10500 1.1 11.0OE-123 U3115119'.1 NT Human phosphoenolpyruvate carboxyikinase (PCK1) gene, promoter region and partial cds 996 673-8 11292 1.3 1.0OE-123 AL163249.2 NT Homo sapJens chromosome 21 segment HS21 C049 1005 6145 11299 1.7 11.0012-123 5803114 NT Homo saplens Inner membrane protein, mitochondrial (mitofilin) (IMMT), mRNA C_ Page 159 of 196 Table 4

1218 6348 11508 1.1 1.OOE-123 4505818 NT Homo sapiens phosphaddylinositol4-phosphate 5-kinase, type 11, beta (P1P5K2B) mRNA, and translated products 1218 6348 11509 1.1 1.OOE-123 4505818 NT Homo saplens phosphaddylinositol- 4-phosphate 5-kinase, type 11, beta (P1P5K2B) mRNA, and translated products 1293 6422 11588 0.9 1.OOE-123 AW362922.1 EST HUMAN RC1-CTO295-241199-01 1- a03 CT0295 Homo sapiens cDNA 1439 6566 11743 0.6 1.OOE-123 AJ388641.1 NT Homo sapiens partial mRNA for immunoglobuifn kappa chain variable region (IGVK gene), sample GNO2 2052 7164 12369 1.1 1.OOE-123 4502072 NT Homo saplin amelogenin (Y chromosomey (AMELY) mRNA 2052 7164 12370 1.1 1.0OE-123 4502072 NT Homo sapiens amelogenin (Y chromosome) (AMELY) mRNA 2052 7164 12371 1.1 1.OOE-123 4502072 NT Homo saplens amelogenin (Y chromosome) (AMELY) mRNA 2267 7373 1.6 1.OOE-123 7705962 NT Homo saplens RAB941ke protein (LOC51209), mIRNA 268 5455 10580 1.1 1.00E.1F4 4507500 NT Homo sapiens T-cell lymphoma invasion and metastasis 1 (TIAM1) mRNA 268 5455 10581 1.1 1.OOE-124 4507500 NT Homo sapiens T-cell Jymphoma Invasion and metastasis 1 (TIAM1) mRNA 273 5461 0.7 1.0012-124 D87675.1 NT Homo sapiens DNA for amytoid precursor protein, complete cds 477 5643 10770 0.7 1.OOE-124 AL163246.2 NT Homo sapiens chromosome 21 segment HS21 C046 676 5831 10961 0.7 1.OOE-124 AA397551.1 EST HUMAN zt81b04.rl Stratagene schizo brain S1 1 Homo sapiens cDNA done IMAGE:728719 5'similar to TR:G300482 G300482 P01---=REVERSETRANSCRIPTASE HOMOLOG {RETROVIRAL ELEMENT); 676 5831 10962 0.7 1.OOE-124 AA397551.1 EST-HUMAN zt81 b04.rl Stratagene schizo brain S1 1 Homo sapiens cIDNA done IMAGE:728719 5' similar to TR.G300482 G300482 P01---=REVERSETRANSCRIPTASE HOMOLOG (RETROVIRAL ELEMENT}; 742 5895 11041 1.3 1.00E72-4 AF155654.1 NT Human puta ve ribosomal protein S1 mRNA 791 5942 11093 1.1 1.OOE-124 4507500 NT Homo sapiens T-cell lymphoma Invasion and metastasis 1 (TIAM1) mIRNA 886 6034 11192 0.6 1.0OE-124 7705446 NT Homo saplens hypothetical protein (HSPC068), mRNA 1324 6453 11618 2.0 1.OOE-124 AF274892.1 NT Homo saplens glucose transporter 3 gene, exon 9, 10, and complete cds 1324 6453 11619 2.0 1.OOE-124 AF274892.1 NT Homo sapiens glucose transporter 3 gene, exons 9, 10, and complete cds 1773 6894 12082 0.9 1.OOE-124 AJ131712.1 NT Homo saplens mRNA for nudeolar RNA-helicase (nol-161 gene) 1802 6921 12107 0.9 1.OOE-124 4508032 NT Homo sapiens zinc finger protein 76 (expressed in tesds) (ZNF76) mRNA 2309 7412 0.8 1.009-124 AW846943.1 EST HUMAN IRC3-CTO1 97-150999-011 -GO5 CTO1 97 Homo sapiens eDNA 2408 7507 12714 0.9 1.OOE-124 A13024069.1 NT Homo saplens gene for B120, exon 11 3319 8464 13577 0.9 110OE-124 4504116 NT Homo sapiens glutarnate receptor, lonotroplc, kainate 1 (GRIK1) mRNA 3446 8588 13701 1.0 1.0012-124 S78684.1 NT Homo sapiens ATP-sensitive inwardly rectifying K-channel subunit (KCNJ6/BIR1) gene, exon 3446 8588 13702 1.0 1.0DE-124 S78684.1 NT Homo sapiens ATP-sensitive inwardly rectifying K-channel subunit (KCNJ6/BIR1) gene, exon 3598 8737 13832 3.0 1.0OE-124 X1 3794,1 NT H.saplens lactate dehydrogenase B gene exon 1 and 2 (EC 1. 1. 1.27) (and joined CDS) 3825 8962 14060 1.1 1.OOE-124 4507500 NT Homo sapiens T-cell lymphoma Invasion and metastasis 1 (TIAM1) mRNA 3983 9115 14198 1.2 1.OOE-124 4504116 NT Homp saplens glutamate receptor, ionotroplc, kainate 1 (GRIKI) mRNA 4639 9753 14847 1.6 1.OOE-124 A13024069.1 NT Homo saplens gene for B1 20, exon 11 1.OOE-1241A1204535.1 4850 9957 1.1 1.OOE-124 M18178.1 NT Human fibronectin gene extra type Iti repeat (EDII), exon x+l 5039 10139 15217 2.7 EST HUMAN qf56h03.xl Soares tests NHT Homo sapiens cDNA clone IMAGE: 1754069 3' Page 160 of 196 Table 4

316 5500 1.8 1.OOE-125 AB032998.1 NT Horno sapiens mRNA for K1AA1 172 protein, partial cds 628 5787 10909 0.6 1.OOE-125 All 10656.1 EST HUMAN HA0086 Human fetal liver cIDNA library Homo sapiens cDNA 628 5787 10910 0.6 1.OOE-125 A1110656.1 EST HUMAN HA0086 Human fetal liver cDNA library Horno sapiens cDNA 711 5865 11001 1.2 1.OOE-125 AF264750.1 NT Homo sapiens ALR-like protein mRNA, partial cds 842 5991 11151 0.7 1.0OE-125 AA042613.1 EST-HUMAN zk53c07.sl Soares_pregnant uterus NbHPU Homo sapiens cDNA done IMAGE:486540 X similar to gb:X65857_0sl 0EFACT5RY RECEPTOR-LIKE PROTEIN HG1VIP07E (HUMAN); 982 6127 11282 0.5 1.0OE-125 AL163210.2 NT Homo saplens chromosome 21 segment HS21 C01 0 1136 6272 11422 0.6 1.0012-125 7662279 NT Homo sapiens KIAA0744 gene product; histone deacetylase 7 (K1AA0744), mRNA 1649 7922 11946 1.1 1.OOE-125 7661867 NT Homo saplens KIAA0022 gene product (K1AA0022), mRNA 1769 6890 12077 1.4 1.OOE-125 AF01WO.1 NT Homo sapiens Usurpin-alpha mRNA, complete cds 1769 6890 12078 1.4 1.OOE-125 AF015450.1 NT Homo saplens Usurpin-alpha mRNA, complete cds 2395 7495 0.9 1.OOE-125 6005756 NT Homo sapiens chromafin-spedfic transcription elongaton factor, 140 kDa subunit (FACTP140), mRNA 2455 7554 12760 1.2 1.OOE-125 AA042813.1 EST-HUMAN zk53c07.sl Soares_pregnanLuterus-NbHPU Homo sapiens cDNA clone IMAGE:486540 X similar to gb:X65857_cdsl OLFACTORY RECEPTOR-LIKE PROTEIN HGMP07E (HUMAN); 2551 7646 12847 0.6 1.0OE-125 4504696 NT Homo sapiens Inhibin, alpha (INHA) mRNA 2551 7646 12848 0.6 1.OOE-125 4504696 NT Homo saplens inhibin, alpha (INHA) mRNA 2555 7649 12852 0.9 1.OOE-125 A1732966.1 ESI-HUMAN. oh64d02.x5 NCI_PGAP Kid5 Horno, saplens cDNA done IMAGE:1471779 X 3089 8240 13340 1.4 1.0OE-125 P52742 SWISSPROT ZINC FINGER PROTEIN 135 3089 8240 13341 1.4 1.00IE-125 P52742 SWISSPROT ZINC FINGER PROTEIN 135 3089 8240 13342 1.4 1.0OE-125 P52742 SWISSPROT ZINC FINGER PROTEIN 135 4516 9635 14727 0.8 1.0OE-125 SE315412.1 EST-HUNIAN 601141152F1 NIK_WL9 Homo spúiens cDNA done IMAGE:3140796 5' 757 5909 11057 0.9 1.OOE-126 4758007 NT Homo sapiens CDC-like kinase (CLK) mRNA 760 5912 11060 1.2 1.0OE-126 M61936.11 NT Human laminin 81 chain gene, exon 20 645 5994 2.5 1.OOE-126 AW578952.1 EST-HUMAN PM2-CT0328-100100-001-h12 CT0328 Homo saplens cDNA 901 6048 11202 0.7 1.OOE-126 X68735.1 NT H.sapiens gene for alphal- antichymotrypsin, exon 3 2371 7473 0.7 1.0OE-126 BE258140.1 EST-HUMAN 601114764F1 NIHMGC16 Homo sapions cDNA done IMAGE:3355622 51 2552 7647 12849 0.8 11.0OE-126 6382078 NT Homo sapiens RAN binding protein 2 (RANI3P2), mRNA 2754 7838 13039 1.8 1.0012-126 BE2792-50.1 EST-HUMAN 601122073F1 NIH_MGQ_20 Homo sapiens cDNA done IMAGE:3346075 5' 3035 8187 13289 6.1 1.0OE-126 AA160709.1 EST_HUMAN zo72c03.rl Stratagene pancreas (#937208) Horno sapiens cDNA clone IMAGE:592420 5, 3035 8187 13290 6.1 1.OOE-126 AA160709.1 EST HUMAN zo72c03xl Stratagene pancreas (#937208) Horno sapiens cDNA clone IMAGE:592420 5' 3577 8716 13813 1.2 1.OOE-126 X53941.1 NT H.sapiens DNA for liver cytochrome b5 pseudogene 3605 8744 13839 2.0 1.OOE-126 7657038 NT Homo saplens death receptor 6 (DR6), mRNA 4677 9789 14888 1.0 1.00E.126 AF101108.1 NT Homo saplens collagen type Xl alpha-1 (COL1 1A1) gene, exon 63 4677 9789 14889 1.0 1.0OE-126 AF101108.1 NT Homo sa lens collagen type XI alpha-1 (COLI1A1) gene, exon 63 4728 9840 14932 1.6 1.OOE-126 N34078.1 EST HUMAN yx78c06xl Scares melanocyte 2NbHM Homo sapiens cDNA done IMAGE:267850 S' 5360 10486 1.2 1.OOE-127 AB024597.1 NT Homo saplens mRNA for casein kinase 1 epsilon, complete ods \P (1 Page 161 of 196 Table 4

5360 10487 1.2 1.0OE-127 A13024597.11 NT Horno sapiens mRNA for casein kinase 1 epsilon, complete cds 166 5360 10486 0.8 1.OOE-127 AB024597.1 NT Homo sapiens mRNA for casein kinase 1 epsilon, complete cds 166 5360 10487 0.8 1.0OE-127 AB024597.1 NT Homo sapiens mRNA for casein kinase 1 epsilon, complete cds 272 5460 10588 0.8 1.0012-127 D87675.1 NT Homo saplens DNA for arnylold precursor protein, complete cds 272 5460 10589 0.8 1.OOE-127 D87675.11 NT Homo sapiens DNA for arnylold precursor protein, complete cds 863 6011 11172 1.3 1.0OE-127 AF1 14488.1 NT Homo saplens intersectin short isoform (tTSN) mRNA, complete cds 898 6045 11201 1.3 1.OOE-127 U72621.2 NT Homo saplens lost on transformation LOT1 mRNA, complete cds 1665 6789 11965 1.0 1.OOE-127 4827053 NT Homo sapiens ubiquifin specific protease 8 (USP8) mRNA 2020 71313 12332 0.6 1.OOE-127 5803065 NT Homo sapiens leukocyte immunoglobutin-like receptor, subfamily A (with TM domain), member 1 (LILRA1), mRNA 2020 7133 12333 0.6 1.OOE-127 5803065 NT Homo sapiens leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 (LILRA1), mRNA 2153 7263 12471 2.7 1.OOE-127 4506620 NT Homo sapiens ribosomal protein L26 (RPL26) mRNA 2566 7659 12862 1.0 1.OOE-127 4557887 NT Homo sapiens keratin 18 (KRT18) mRNA 2579 7672 12873 1.0 1.OOE-127 AW403790.1 EST HUMAN Ut-HF-BKO-abn-a-06-0- Ut.rl NIM_MGC_36 Homo sapiens eDNA clone IMAGE:3056555 5' 2579 7672 12874 1.0 1.0012-127 AW403790.1 EST HUMAN U]-HF-BKO-abn-a-06-0- Ul.rl N11-1-1VIGC_36 Homo sapiens cDNA clone IMAGE:3056555 5' 3436 8578 13689 1.0 1.OOE-127 AW610485.1 EST-HUMAN RCO-ST0379-210100-032- h12 ST0379 Homo sapiens cDNA 3436 8578 13690 1.0 1.OOE-127 AW610485.1 EST HUMAN RCO-ST0379-210100-032h12 ST0379 Homo saRiens cDNA 3740 8877 13967 0.9 1.OOE-127 AW161297.1 EST&HUMAN au80e06.yl Schnelder fetal brain 00004 Homo sapiens cDNA clone IMAGE:2782594 5' similar to TR:Q15170 Q15170 TRANSCRIPTION FACTOR S-II-RELATED PROTEIN xontains element MER22 repetitive element; 4026 9154 14238 1.1 1.OOE-127 AF135188.1 NT Hamo sapiens delayed rectifier potassium channel subuffit IsK mRNA, complete cds 4128 9254 14334 0.9 1.0OE-127 A1.163247.2 NT Homo sapiens chromosome 21 segment HS21C047 4160 9286 14365 21.5 1.00EA 27 7706239 NT Homo sapiens neuroblastoma- amplified protein (LOC51 594), mRNA 4160 9286 14366 21.5 1.ODE-127 7706239 NT Homo sapiens neuroblastoma- amplified protein (LOC51594), mRNA 4395 9517 14607 0.9 1.OOE-127 AF252297.11 NT Homo sapiens cytochrome F450 rednold metabolizing protein P45ORAI-2 mRNA, complete cds 4499 9619 14710 4.2 1.OOE-127 4506384 NT Homo saplens RAD1 (S. pombe) homolog (RAD1) mRNA, and translated products 4532 9651 1.9 1.OOE-127 AL163268.2 NT Homo sapiens chromosome 21 segment HS21 C068 4575 9692 14784 1.0 1.00EA27 6912639 NT Homo sapiens Rin91 and YY1 binding protein (RYBP), mRNA 452 5618 10746 1.5 1.0OE-128 BE385617.1 EST HUMAN 601278127F1 N1H MGS.20 Homo saplens cDNA done IMAGE:3618822 5, 1138 6274 11424 1.5 1.OOE-128 4758081 NT Homo saplens chondroffin sulfate proteoglycan 2 (versican) (CSPG2) mRNA 1138 6274 11425 1.5 1.OOE-128 4758081 NT Homo sapiens chondroitin sultate proteoglycan 2 (versican) (CSPG2 mRNA 2025 7138 12337 4.4 1.00EA28 U02523.1 NT Human FAUll P pseudogene, binucleotde repeat regions 2025 7138 12338 4.4 1.OOE-128 U02523.11 NT Human FAU1 P Rseudogene, tdnucleofide repeat regions 2162 7271 12482 4.8 1.00EA28 4506718 NT Homo sapiens dbosomal protein S2 (RPS2) mRNA 3348 8492 13603 1.1 1.OOE-128 AB033073.1 NT Horno sapiens mRNA for K1AA11 247 protein, partial cds 1 5575 10714 2.2 1.00EA29 S37722.1 NT insulin-like growth factor binding protein-2 (human, placenta, Genomic, 1019 nt, segment 2 of 4) N V\ (-l Page 162 of 196 Table 4

407 5575 10714 0.8 1.OOE-129 S37722.1 NT Jnsulin-like growth factor binding protoin-2 [human, placenta, Genomic, 1019 nt, segment 2 of 41 1689 6813 11993 1.0 1.OOE-129 AL096880.1 NT Novel human mRNA containing ZInc finger C2H2 type domains 2751 7835 13035 1.2 1.OOE-129 4505682 NT Homo sapiens platetel-derived growth factor receptor, beta polypeptide (PDGFRB) mRNA 2751 7835 13036 1.2 1.OOE-129 4505682 NT Homo saplens platelet-derived growth factor receptor, beta poiypepdde (PDGFRB) mIRNA 4004 9135 14217 6.1 1.OOE-129 4504686 NT Homo sapiens IMP (inosine monophosphate) dehydrogenase 1 (IMPIDH1) mRNA 4073 9200 14286 2.2 1.OOE-129 A13040892.1 NT Homo sapiens mRNA for KIAA1459 potein, partialcds 4183 9309 14388 9.7 1.0OE-129 AW755254.1 EST-HUMAN CMYA5 Human cardiac muscle expression library Homo sapiens cDNA clone 4151935 similar to CMYA5 Cardiomyopathy associated gene 5 4183 9309 14389 9.7 1.OOE-129 AW755254.1 EST HUMAN CMYAS Human cardiac muscle expression library Homo sapiens cDNA clone 4151935 similar to CMYA5 Cardiomyopathy associated gene 5 192 5386 10513 1.0 1.OOE-130 AF233453.1 NT Homo saplens RACK-like protein PIRKC13P1 (PRKCBPl mRNA, complete cds 192 5386 10514 1.0 1.OOE-130 AF233453.1 NT Homo sapiens RACK-like protein PIRKCBP1 (PIRKC13P1) mRNA, complete eds 993 6136 0.7 1.OOE-130 AJ133269.1 NT Homo saplens caveolin-11-2 locus, Conti91, D7S522, genes CAV2 (exons 1, 2a, and 2b), CAV1 (exons 1 and 2) 994 6136 1.2 1.OOE-130 AJ133269.1 NT Homo sapiens caveolin-11-2 locus, Conti91, D7S522, genes CAV2 (exons 1, 2a, and 2b), CAV1 (exons 1 and 2) 1643 6769 11940 2.5 1.0OE-130 BE275192.1 EST HUMAN 601121995F1 NIKffiC 20 Hom6 sapiens cIDNA done IMAGE:3346366 5' 1643 6769 119.41 2.5 1.0OE-130 BE275192.1 EST-HUMAN 601121995F1 NIH-MG,20 Homo sapiens cDNA done IMAGE:3346366 5' 1M 7057 0.8 1.0OE-130 X04092.1 NT -Human gene for catalase (EC 1.11.1.6) exo 9 mapping to chromosome 11, band p13 2253 7359 12566 1.5 1.OOE-130 BE280697.1 ES7_HU 601155971F1 NIH MGC 21 Homo sapiens cIDNA done IMAGE:3139408 5' 2253 7359 12567 1.5 1.0OE-130 BE280697.1 EST-HUMAN 601155971 Fl NIM_MGC 21 Homo sapiens cIDNA done IMAGE:3139408 5' 2743 7827 2.8 1.OOE-130 AJ010230.1 NT Homo sapiens RET Anger protein-like 1 andsense transcript, partial 2952 8103 13209 0.8 1.0012-130 4505458 NT Homo sapiens neuropilin 2 (NIRP2) mRNA 2952 8103 13210 0.8 1.OOE-130 4505458 NT Homo sapiens'neuropilin 2 (NIRP2) mRNA 3530 8671 13775 1.1 1.0OE-130 AF240698.1 NT Homo sapiens rednol dehydrogenase homolog lsoform-1 (RDH) mRNA, complete cds 3857 8993 14092 1.1 1.OOE-130 AW503580.1 EST-HUMAN Ul-HF-BNO-aky-g-06-0- Ul.rl N11-1-1VIGQ_50 Homo sapiens cDNA clone IMAGE:3078731 5, 4438 9559 14654 7.5 1.OOE-130 AW843993.1 EST HUMAN CM4.CN0045-180200-51 1402 CN0045 Homo sapiens cDNA 5029 10130 15205 1.1 1.OOE-130 AW363299.1 EST-HUMAN RCO-CTO318-201199-031 -all CT0318 Homo sapiens cDNA 5029 10130 15206 1.1 1.00EA 30 AW363299.1 EST-HUMAN RC(CT0318-201199-031 - all CT0318 Homo sapJens cDNA 4 5213 10314 0.9 0 AA228126.1 EST HUMAN zr58c04xl Soares-Nhi-IMPLLS1 Homo sapiens cIDNA done IMAGE:667590 5'slmilar to TR:G2228111 G222811 ALPHA 1 CHAIN OF TYPE XII COLLAGEN.; 4 5213 10315 0.9 0 AA228126.1 EST-HUMAN zr58c04xl Soares_Nhi-IMPq_S1 Homo sapiens cONA done IMAGE:667590 5'similar to TR:G2228111 G222811 ALPHA 1 CHAIN OF TYPE XII COLLAGEN.; 7 5215 10318 1.4 0 4885136 NT Homo sapiens checkpoint suppressor 1 (CHES1), mIRNA 15: 5223 10324 1.3 0 8923349 NT Homo sapiens hypothetical protein FLJ20371 (FLJ20371), mRNA 5223 10325 1.3 0 8923349 NT Homo sapiens hypothetical protein FLJ20371 (RJ20371), mRNA 5229 10331 2.5 0 D83327.1 NT Homo sapiens DCRRI mRNA, partial ods C( kJ- Page 163 of 196 Table 4

5229 10332 2,5 0 D83327.1 NT Homo sapiens DCRR1 mRNA; partial cds 24 5233 10336 1.9 0 AF141349.1 NT Homo sapiens beta-tubulin mRNA, complete ods 33 5242 10348 1.0 0 M58600.1 NT Human heparin cofactor 11 (HCF2) gene, exons 1 through 5 5244 10351 0.8 0 6857825 NT Homo sapiens RNA-binding protein S1, sedne- rich domain (RNPS1), mRNA 51 5260 10377 1.4 0 Y1 7151.2 NT Homo sapiens mRNA for mulfidrug resistance protein 3 (ABCC3) 51 5260 103781 1.4 0 Y17151.2 NT Homo sapiens mRNA for mulddrug resistance protein 3 (ABCC3) HUM516HO8B Human placenta polyA+ (TFujiwara) Homo, sapiens cIDNA clone GEN-5161-10Y 52 5261 10379 1.2 0 D78804.1 EST HUMAN 5' HUM516HO8B Human placenta polyA+ (TFujiwara) Homo sapiens cIDNA clone GEN- 516H08 52 5261 10380 1.2 0 D78804,1 EST-HUMAN 5' 53 5262 10381 1.4 0 L16558.1 NT Human dbosoffial protein L7 (RPL7) mRNA, complete cds 5264 10384 2.8 0 AW069534.1 EST-HUMAN cr48e07.xl Jia bone marrow stroma Horno sapiens cDNA done HBMSC cr48e07 3' 5264 10385 2.8 0 AW069534.1 EST HUMAN cr48e07.xl Jia bone marrow stroma Homo sapiens cIDNA clone I-IBIVISC cr48e07 3, 59 5267 10369 2.0 0 M60676.1 NT Human von Willebrand factor pseudogene corresponding to exons 23 through 34 61 5269 0.9 0 M60676.1 NT Human von Willebrand factor pseudogene corresponding to exons 23 through 34 Homo sapiens protein tyrosine phosphatase, non-receptor type substrate 1 (PTPNS1) mRNA 69 5276 104011 0.6 0 4758977 NT 69 5276 10402 0.6 0 4758977 NT Homo sapiens protein tyrosine phosphatase, non-receptor type substrata 1 (PWNS1) mRNA 71 5276 10401 0.5 0 4758977 NT Homo sapiens protein tyrosine phosphatase,. non-receptor type substrate 1 (PTPNS1) mRNA 71 5276 104021 0.5 0 4758977 NT Homo sapiens protein tyrosine phosphatase, non-receptor type substrate 1 (PTPNS1) mRNA on89c04.sl Soares_NFL-T-Gl3Q_S1 Horno saplens cDNA clone IMAGE:1563870 3' similar 74 5280 10407 14.0 0 AA953770.1 EST HUMAN to SW:TMOD-HUMAN P28289 TROPOMODULIN.; Homo sapiens amiloride binding protein 1 (amine oyJdase (copper- containing)) (A13P1), 76 5282 10409 1.1 0 4501850 NT nuclear gene encoding mitochondrial protein, mRNA 77 52831 5.0 0 4504444 NT Homo sapie a heterogeneous nuclear dbonucleoprotein A1 (HNRPA1) mRNA 86 5292 10418 16.0 0 5016088 NT Homo sapiens actin, beta (ACTB) mRNA 89 5295 10421 4.6 0 U89277.1 NT Human polyhomeofic 1 homolog (HPH1) mRNA, partial cds 94 5301 10427 1.5 0 A] 114743.1 EST HUMAN HA1 347 Human fetal liver cDNA library Horno sapiens cDNA 5302 10428 1.0 0 AB037784.1 NT Homo sapiens mIRNA for K[AA1 363 protein, partial cds 102 5307 10433 2.1 0 X91213.1 NT H.sapiens ncxl gene (exon 2) ts38b05.xl NCI-CGAP-Ut4 Homo, sapiens cDNA clone IMAGE:2230833 3'similar to TR:Q99551 Q99551 MITOCHONDRIAL TRANSCRIPTION TERMINATION FACTOR 53131 10438 1.4 0 A1623701.1 EST HUMAN PRECURSOR.; ts38b05.xl NCI_CGAP_Ut4 Homo sapiens cDNA clone IMAGE:2230833 3' similar to TR:Q99551 Q99551 MITOCHONDRIAL TRANSCRIPTION TERMINATION FACTOR 111 5313 10438 0. ECURSOR.; 112 7858 10439 0.6 0 N36040.1 EST HUMAN yy01h09xl Soares melanocyte 2NbHM Homo sapiens cDNA clone IMAGE:270017 5' 112 7858 104401 0.6 1 0 IN36040.1 1EST HUMAN 501 hOg.rl Soares. melanocyte 2NbHM Horno sapiens cDNA clone IMAGE:27001 Page 164 of 196 Table 4

V\ Page 165 of 196 5316 10445 0.9 0 4505458 NT Homo sapiens neuropilin (NRP2) mRNA 126 5322 10453 1.1 0 4505938 NT Homo sapiens polymerase (RNA) 11 (DNA directed) polypeptide A (220k13) (POLR2A) MRNA 126 5322 1 1.1 04505938 NT Homo sapiens polymerase (RNA) 11 (DNA directed) polypeptide A (220k13) (POLR2A) mRNA 5330 10461 0.5 0 T56945.1 EST HUMAN ya83g04x2 Stratagene fetal spleen (#937205) Homo sapiens cDNA done IMAGE:68310 5, 5330 10462 0.5 0 T56945.1 EST HUMAN ya83g044 Stratagene fetal spleen (#937205) Homo sapiens cDNA Clone IMAGE:68310 5, 147 5343 3.1 0 4504444 NT Homo sapiens heterogeneous nuclear dbonudeoproteiti A1 ( RPA1) mRNA 153 5349 10478 5.4 0 4504444 NT Homo sapiens heterogeneous nuclear dbonudeoprotein A1 (HNRPA1) mRNA 156 5352 1.4 0 AF1 11168.2 NT Homo sapiens serine paimitoyl transferase, subunit 11 gene, complete cds; and unknown genes 158 5354 10479 1.1 0 BE295973.1 EST HUMAN 601174270F1 Nffl_1VIGC 17 Homo sapiens cDNA clone IMAGE:3529864 5' 159 5354 10479 1.2 0 BE295973.1 EST HUMAN 601174270F1 NIH-WC-1 7 Homo saplens cDNA clone IMAGE:3529864 5' 5355 10480 1.0 0 W73973.1 EST HUMAN zd62b05xl Scares fetal - heark_NbHH19W Homo sapiens cDNA clone IMAGE:345201 5, similar to gb:X16282 cdsl ZINC FINGER PROTEIN CLONE 647 (HUMAN); 161 5356 10481 0.5 0 AF244088.1 NT Homo sapiens zinc finger protein mRNA, complete cds 164 5359 10484 6.3 0 AL163202.2 NT Homo sapiens chromosome 21 segment HS21 C002 16.4 5359 10485 6.3 0 AL163202.2 NT Homo sapiens chromosome 21 segment HS21 C002 174 5367 10492 1.5 0 BE018970.1 EST-HUMAN bb24c12.yl N1H IVIGQ_114 Homo sapions cDNA done IMAGE:2963854 Csimflar to WP:Y57A10A.Z'E22631; 174 5367 10493 1.5 0 BE018970.1 EST HUMAN bb24e12.yl N1H - MGQ_14 Homo sapiens cD.NA done IMAGE:2963854 Ysimilar to WIP:Y57A1 OA.Z CE22631; 179 5372 10496 0.7 0 A13018327.1 NT Homo sapiens mRNA for KIAA0764 protein, partial cds 179 5372 10497 0.7 0 A13018327.1 NT Homo saple s mRNA for KIAA0784 protein, partial ods 187 5381 10508 44.0 0 D50659.1 NT Human gamma-cytoplasmic actin (ACTGP9) pseudogene, 194 5388 10516 1.0 0 AF167174.1 NT Homo saplens chromosome X MS1-3-2 protein mRNA, complete cds 194 5388 10517 1.0 0 AF167174.1 NT Homo sapiens chromosome X MSL3-2 protein mRNA, complete cds 203 7883 10523 3.2 0 A1587308.1 EST HUMAN tqO4f08.xl NCI-C_W Homo sapiens eDNA done IMAGE:2207847 Ysimilar to gb:J031191 PROFILIN 1 (HUMAN); 203 7883 10524 3.2 0 A1587308.1 EST HUMAN tq0008.xl NCI_PGAP---W Homo sapiens cDNA clone IMAGE:2207847 3'similar to gb:J03191 PROFILIN 1 (HUMAN); 205 5398 10526 0.7 0 AF195658A NT Homo sapiens DNA mismatch repair protein (M1-1-13) gene, co plete cds 208 5401 5.7 0 4506632 NT Homo sapiens dbosomal protein L31 (RPL31) mRNA 209 5402 1.2 0 AF132000.1 NT Homo sapiens TADAII protein mIRNA, complete ods 215 5408 10531 0.9 0 AB01 8264.1 NT Homo sapiens mRNA for KIAA0721 protein, partial cds 216 5408 10531 0.7 0 A13018264.1 NT Homo saplens mRNA for KIAA0721 protein, partial cds 5409 10532 0.6 0 5578444 NT Mus musculus tesds-specific proteh, Y-encoded- like (TspA), mRNA 5417 10536 1.2 0 BE246780.1 EST HUMAN TCBAP1E4466 Pedlatric pre-B cell acute lymphoblastic leukernia Baylor-HGSC project=TCBA Homo saplens cDNA done TCBAP4466 Table 4

Page 166 of 196 224 5417 10537 1.2 0 BE246780.1 EST HUMAN TCBAP1E4466 Pediatric pre-B cell acute lymphoblastic leukemia Baylor-HGSC project--TC13A Horno sapiens cDNA clone TCBAP4466 224 5417 10538 1.2 0 BE246780.1 EST-HUMAN TCBAPIE4466 Pediatric pre-B cell acute lymphoblastic leukemia Baylor-HGSC 225 5417 10536 1.4 0 BE246780.1 EST HUMAN project=TC13A Homo saplens cDNA done TCBAP4466 TC13AP1 E4466 Pediatric pre-B cell acute lymphoblastic leukemia Baylor- HGSC project=TCBA Homo sapiens cDNA clone TCBAP4466 225 5417 10537 1.4 0 BE246780.1 EST HUMAN TCBAP19 66 Pediatricpre-B cell acute lymphoblastic leukemia Baylor-HGSC project=TCBA Homo sapiens cDNA cAone TCBAP4466 225 5417 10538 1.4 0 BE246780.1 EST-HUMAN TCBAPIE4466 Pediatric pre-B cell acute lymphoblastic leukemia Baylor-HGSC project=TCBA Homo sapiens cDNA clone TCBAP4466 226 5417 10536 4.3 0 BE246780.1 EST HUMAN TC13AP1 E4466 Pediatric pre-B cell acute lymphoblastic leukemia Baylor-HGSC project--TCBA Homo sapiens cDNA clone TCBAP4466 226 5417 10537 4.3 0 BE246780.1 EST HUMAN TWAP1 E4466 Pedlatric pre-B cell acute lymphoblastic leukemia Baylor-HGSC project--TC13A Homo sapiens cDNA clone TCBAP4466 226 5417 10538 4.3 0 BE246780.1 EST HUMAN TCBAP1E4466 Pediatric pre-B cell acute lymphoblastic leukemia Baylor-HGSC project=TCBA Homo sapiens cDNA clone TCBAP4466 238 5428 10555 1.6 0 5453805 NT Homo sapiens NS1-assoclated protein 1 (NSAP1) mRNA 240 5430 2.2 0 AL163201.2 NT Homo sapiens chromosome 21 segment HS21 C001 247 5435 10561 1,3 0 AF231919.1 NT Homo saplens; chromosome 21 unknown mRNA 249 5437 10564 1.5 0 X89772.1 NT H.sapiens mRNA for interferon alphalbeta receptor (long form) 257 5445 2.3 0 AF231919.1 NT Homo sapiens chromosome 21 unknown mRNA 269 5456 10582 1.1 0 4507500 NT Homo saplens T-cell lymphoma invasion and metastasis 1 (TIAM1) mRNA 269 W6 10583 1.1 0 4507500 NT Homo sapiens T-cell lymphoma Invasion and metastasis 1 (TIAM1) mRNA 270 5458 10585 0.9 0 7706028 NT Homo sapiens hypothetical protein (LOC51250), mRNA 281 5468 1059g 1.1 0 D83327.1 NT Horno sapien DCRR1 mRNA, partial ods 281 5468 10599 1.1 0 D83327.1 NT Homo saplens DCRR1 mRNA, partial cds 282 5469 0,9 0 AW845293.1 F-ST HUMAN 11-2-CT0031-181199-020-1303 CTO031 Homo sapiens cDNA 290 5476 10606 1.8 0 4557029 NT Homo sapiens potassium inwardiy-recdfying channel, subfamily J, member 15 (KCNJ 15) 290 5476 10607 1.8 0 4557029 NT mRNA Homo sapiens potassium inwardly-rectifying channel. subfamily J, member 15 (KCNJ 15) mRNA 301 5487 10617 1.4 0 A13028942.1 NT Homo sapiens mRNA for KIAA1019 protein, partial cds 302 5488 10618 1.1 0 AB028942.1 NT Homo saplens mRNA for K1AA1 019 protein, partial cds 303 7886 1.8 0 4506728 NT Homo saplens dbosomal protein S5 (RPS5) mRNA 304 5489 10619 0.7 0 4503914 NT Homo sapiens phosphodbosyiglydnamide formyltransferase, phosphodbosyiglycinamide synthetase, phosphodbosylaminoimidazole synthetase (GART) mRNA 305 5490 0.7 0 AA480002.1 EST HUMAN zvl8cO6.rl Soares_Nhi-IMPu S1 Homo sapiens cDNA clone IMAGE:753994 5' 306 5491 10620 3.3 0 4507152 NT Horno saplens SON DNA binding protein (SON) mRNA 307 5491 10620 4.5 0 4507152 NT Homo sapiens SON DNA binding protein (SON) mRNA 311 549 0.8 0 AF1 14488.1 NT Homo sapiens Intersectin short lsoform (ITSN) mRNA, complete cds Table 4

Page 167 of 196 324 5507 10633 0.9 0 014867 SWISSPROT TRANSCRIPTION REGULATOR PROTEIN BACH1 (BTB AND MC HOMOLOG 1) (HA2303) 324 5507 10634 0.9 0 014867 SWISSPROT TRANSCRIPTION REGULATOR PROTEIN BACH1 (BTB AND CNC HOMOLOG 1) (HA2303) 325 5508 10635 1.4 0 7657213 NT Homo saplens hormonally upregulated nou tumor-associated kinase (HUNK), mRNA 326 5508 10635 0.8 0 7657213 NT Homo sapiens hormonally upregulated neu turnor-associated kinase (HUNK), mRNA 341 5522 10647 1.3 0 5174574 NT Homo sapiens mycloidilymphold or mixed- lineage leukernia (trithorax (Drosophila) homolog); translocated to, 4 (MI-LT4) mRNA 342 5523 10648 0.9 0 4505256 NT Homo sapiens moesin (MSN), mRNA 345 5526 10652 1.3 0 4827057 NT Horno sapiens X-box binding protein 1 (XBPl) mRNA 348 5529 10657 0.8 0 U71600.1 NT Human dric finger protein zfp31 (zf311) mRNA, partial cds 353 5533 10661 0.7 0 AF23191 9.1 NT Homo saplens chromosome 21 unknown mRNA 353 5533 10662 0.7 0 AF231919.1 NT Homo sapiens chromosome 21 unknown mRKA 354 7887 10663 1.2 0 AF231919.1 NT Homo sapiens chromosome 21 unknown mRNA 356 5535 10665 0.9 0 4507500 NT Homo sa lens T-cell lymphoma Invasion and metastasis 1 (TIAM1) mRNA 358 5537 10668 1.4 0 4503854 NT Homo sapiens GA-binding protein transcription factor, alpha subunit (60kD) (GABPA), mRNA 359 5538 10669 1.4 0 D80006.1 NT Human mRNA for KIAA0184 gene, partial ods 360 5538 10669 0.5 0 D80006.1 NT Human mRNA for KIAA0184 gene, partial ods 381 5587 10720 1.8 0 A8028942.1 NT Horno sapiens mRNA for K1AA10119f protein, partial cds 382 5588 10721 1 0 A1363014.1 EST HUMAN qy81h05.xl NCI-CGAP_Bm25 Homo, sapiens cDNA cone IMAGE:2018457 Ysimilar to gb:X54199 PHOSPHORIBOSYLAMINE-GLYCINE LIGASE (HUMAN); 387 5556 10688 3.4 0 AW754180.1 EST HUMAN RC2-CTO320-300100-016-a09 CT0320 Horno sapiens cDNA 390 5558 10691 1.4 0 4503680 NT Homo saplens 19G Fc binding protein (FC(GAMMA)BP) mRNA 391 5559 10692 0.7 0 4503680 NT Homo saplens IgG Fc binding protein (FC(GAMMA)BP) mRNA 391 5559 10693 0.7 0 4503680 NT Homo sapi ns 19G Fc binding protein (FC(GAMMA)121P) mRNA 392 5560 10694 1.2 0 4503680 NT Horno sapiens IgG Fc binding protein (FC(GAMMA)BP) mRNA 393 5561 10695 0.6 0 4503680 NT Homo saplens 19G Fc binding protein (FC(GAMMA)121P) mRNA 393 5561 10696 0.6 0 4503680 NT Homo sapiens IgG Fc binding protein (FCI(GAMMA)BP) mRNA 394 5562 10697 2.4 0 4503680 NT Homo sapiens 19G Fc binding protein (FC(GAMMA)BP) mRNA 395 5563 10698 0.9 0 4503680 NT Homo saple s IgG Fc binding protein (FC(GAMMAfflP) mRNA 396 5564 10699 0.8 0 X74870.11 NT H.sapiens gene for RNA poll 11 largest subuffit, exons 23-29 396 5564 10700 0.8 0 X74870.1 NT H.saplens gene for RNA pold largest subunit, exons 23-29 400 5568 15.0 0 4506608 NT Homo sapiens ribosomal protein L19 (RPL19) mRNA 414 5203 10304 1.3 0 R17795.1 EST HUWAN ygO9aO2.rl Soares Infant brain I NIB Homo sapiens cDNA done IMAGE:31652 5' 422 5589 OW9 0 4506728 NT Homo saple s ribosomal protein S5 (RPS5) mRNA 423 5590 10722 0.8 0 AB028942.1 NT Homo saplens mRNA for KIAA1019 protein, partial cds 424 5591 10723 1.6 0 4507152 NT Horno sapiens SON DNA binding protein (SON) mRNA 424 5591 10724 1,6 0 4507152 NT Homo sapiens SON DNA binding protein (SON) mRNA 425 5592 10725 1.2 0 AF193607.1 NT Mus musculus truncated SON protein (Son) mRNA, complete cds 438 5604 10738 0.7 0 4557879 NT Horno saplens interferon gamma receptor 1 (IFNGR1) mIRNA _ Table 4

Page 168 of 196 443 560911 1.0 0 AA324262.1 iEST HUMAN EST27054 Cerebellum 11 Homo sapiens cDNA Vend 444 5610 0.9 0 BE254447.1 EST HUMAN 601111520F1 N1H MGC 16 Homo saplens cDNA done IMAGE:3352348 5' 460 5626 10752 1.1 0 4504532 NT Homo saplens 5-hydroxytryptamine (serotonin) receptor 18 (HTR1 B) mRNA 460 5626 10753 1.1 0 4504532 NT Homo sapiens 5-hydroxy"ptamine (serotonin) receptor 1 B (HTR1 B) mRNA 465 5630 10760 1.3 0 4557887 NT Homo sapiens keratin 18 (KIRT18) mRNA 465 5630 10761 1.3 0 4557887 NT Homo saplens keratin 18 (KRT1 8) mRNA 475 5641 10767 0.8 0 AL163246.2 NT Homo sapiens chromosome 21 segment HS21C046 476 5642 10768 2.4 0 A1-163246.2 NT Homo sapiens chromosome 21 segment HS21 C046 476 5642 10769 2.4 0 AL163246.2 NT Homo saplens chromosome 21 segment HS21 C046 485 5650 10774 0.9 0 AB033035.1 NT Homo sapiens mRNA for K1AA1 209 protein, partial cds 495 5660 10782 0.7 0 BE385144.1 EST HUMAN 601274951 F1 NIH MGC 20 Homo sapjens cDNA done IMAGE:3615756 5, 496 7890 10783 1.1 0 AW938825.1 EST HUMAN PMO-DT0065-130400-002-c06 DT0065 Homo sapiens cIDNA 498 5662 10785 1.1 0 AL1 17233.1 NT Novel human gene mapping to chomosome 1 499 5663 10786 0,6 0 8923955 NT Homo saplens PC326 protein (PC326), mRNA 508 5672 10795 1.3 0 A1.1632110.2 NT Homo saplens chromosome 21 segment HS21 C01 0 515 7891 10799 0.7 0 BE081527.1 EST-HUMAN QV2-BT0635-160400-142-h05 BT0635 Homo sapiens cDNA 526 5690 10812 1.2 0 A13040909.1 NT Homo saplens mRNA for KIAA1476 protein, partial eds 529 5693 10815 3.8 0 6006030 NT Homo sapiens transcription elongation factor B (Sill), polypeptide 1-like (TCEB1 L) mRNA 530 5694 10816 1.4 0 4504036 NT Homo saplens guanine nucleodde binding protein (G protein), alpha 11 (Gq class) (GNA1 1) mRNA 530 5694 10817 1.4 0 4504036 NT Homo sapiens guanine nudeotide binding protein (G protein), alpha 11 (Gq c ass) (GNA1 1) mRNA 536 5699 2.0 0 AF003528.1 NT Homo saplens X-linked anhidroldc ectoderrnal dysplasia protein gene (EDA), exon 2 and flanking repeat regions 544 5707 10827 0.6 0 AW135324.1 EST HUMAN Ul-H-Bil-acb-b-04-0-Ul.sl NCI- CGAP-Sub3 Homo saplens cIDNA clone IMAGE:2713951 3, 554 5717 1.1 0 D10083.1 NT Homo sapiens RGH1 gene, retrovirus-like element 571 5732 10850 0.9 0 5174742 NT Homo sapiens ubiquinol-"chrome c reductase, Rieske iron-sulfur polypepfide 1 (UQCRFSI), nuclear gene encoding mitochonddal protein, mRNA 584 5744 1.8 0 J04066.1 NT Human apolipoprotein A-1 (ApoA-1) gene, exon 1 593 5751 10868 1.5 0 4501854 NT Homo saplens acey-Coonzyme A carboxylase beta (ACACB), mRNA 598 5756 10874 1.1 0 AF2211712.1 NT Homo sapiens Smad-and Olf-interacting zinc finger protein mRNA, partial cds 598 5756 10875 1.1 0 AF221712.1 NT Homo saplens Smad- and Olf-Interacting dric finger protein mRNA, partial cds 607 5765 10883 1.4 0 AF149773.1 NT Homo saplens NODI protein (NOD1) gene, exons 1, 2, and 3 610 5768 10886 1,0 0 6806918 NT Homo sapiens low density lipoprotein- related protein 2 (LRP2), mRNA 611 5769 10887 0.8 0 6806918 NT Homo sapiens low density lipoprotein- related protein 2 (LRP2), mRNA 611 5769 108881: 0.8 0 6806918 NT Homo saplens low density lipoprotein- related protein 2 (LRP2), mRNA 612 5770 16889 0.9 0 6806918 NT Homo saplens low density lipoprotein- related protein 2 (LRP2), mRNA 612 5770 10890 0.9 0 6806918 NT Horno sapiens low density lipoprotein- related protein 2 (LRP2), mRNA 619 5778 10900 1,3 0 AA399486.1 EST HUMAN zt60c07.rl Soares tesfi!_NHT Homo sapiens cIDNA done IMAGE:726732 5' Table 4

623 5782 10904 2.2 0 D111078.1 NT Homo sapiens RGH2 gene, retrovirus-like element 627 5786 10907 1.1 0 W7881 1,1 EST-HUMAN zh51 b04.rl SoaresJetaUlver spleen 1 NFLS S1 Homo sapiens cDNA clone IMAGE:415567 5'sImilar to qj21 1C7 ALPHA--2-MACROGLOBULIN PRECURSOR (HUMAN); 627 5786 10908 1.1 0 W7881 1.1 EST HUMAN zh51 b04.rl Soares-fetal- tiveLspleen 1 NFLS S1 Homo sapiens cDNA clone IMAGE:415567 5'sImilar to gb:A211877 ALPHA-2-MACROGLOBULIN PRECURSOR (HUMAN); 630 5789 1.1 0 4885526 NT Homo saplens novel SH2-containing protein 3 (NSP3) mRNA 637 5796 10920 1,0 0 6006003 NT Homo saplens glutamate receptor, ionotroplc, N-methyl D-aspartate 213 (GRIN213) mRNA 639 5798 10923 1.1 0 5031624 NT Homo saplens CCAAT-box-binding transcription factor (CBF2) mRNA 642 5801 10927 1.4 0 U05235.1 NT Human neutral amino add transporter (ASCT1) gene, exon 8 646 5805 10930 0.7 0 AF108389.1 NT Homo saplens sodium/caidum exchanger Isoform NaCa3 (NCXI) mRNA, complete cds 646 5805 10931 0.7 0 AF108389.1 NT Homo sapiens codiunilcaidum exchanger Isoform NaCa3 (NCX1) mRNA, complete cds 652 5810 10936 1.4 0 4826947 NT Homo sapiens protein kinase, X-linked (PRKX) mRNA 652 5810 10937 1.4 0 4826947 NT Homo, sapiens protein kinase, XAinked (PRKX) mRNA 0 71894 658 1.0 0 X57147.1 NT Human endogenous retrovirus pHE.1 (ERV9) 667 5823 10951 1.6 0 4504424 NT Homo sapiens high-mobility group (nonhistone chromosomal) protein 1 (HIVIG1) mRNA 672 5828 10955 1.5 0 A13029012.1 NT Homo sapiens mRNA for KIAA1089 protein, partial cds 682 5837 10970 0.7 0 7657468 NT Homo sapiens similar to rat integral membrane glycoprotein POM121 (POM121 Ll), mRNA 692 5847 10982 6,6 0 AA614537.1 EST-HUMAN np49d01.sl INICI_CGAP BrIA Homo, saplens cIDNA done IMAGE:1 129633 3, similar to gb:X57352 INTERFERON-INDUCIBLE PROTEIN 1-8U (HUMAN); 696 5861 10986 2.6 0 M60675.11 NT Human von Willebrand factor gene, exons 23 through 34 696 5851 10987 2.6 0 M60675.11 NT Human von Willebrand factor gene,'exons 23 through 34 706 5861 10996 1.5 0 5032192 NT ns TNF receptor-assodated factor 1 (TRAF1) mRNA 712 5866 11002 1.3 0 AF264750.1 NT Homo sapiens ALR-like protein mRNA, partial ods 712 5866 11003 1.3 0 AF264750.1 NT Homo saplens ALR-tike protein mRNA, partial cds 719 5873 11013 0.6 0 BE241577.1 EST HUMAN TCAAPID0779 Pedlatric acute myelogenous leukernia cell (FAB M1) Baylor-HGSC project=TCAA Homo saplens cIDNA clone TCAAP0779 739 5892 11037 1.1 0 AF226990.2 NT Homp saplens MI-IC class 1 antigen (HLA-G) mRNA, HLA-GI allele, complete cds 739 5892 11038 1.1 0 AF226990.2 NT Homo saplens WC class 1 antigen (HLA- G) mRNA, HLA-Gl allele, complete cds 740 5893 11039 2.4 0 AF170492.1 NT Homo saplens chloride channel CLC4 (C1C4) mRNA, complete cds 743 589M 11042 0.5 0 J03764.1 NT Human, plasminogen activator Inhibitor- 11 gene, exons 2 to 9 743 5896 11043 0.5 0 J103764.1 NT Human, plasminogen activator Inhibitor- 11 gene, exons 2 to 9 745 5808 11044 0.8 0 AB037760.11 NT Homo saplens mRNA for K1AA11 339 protein, partial ods 746 5899 11045 1.1 0 6912749 NT Homo sapiens zinc finger protein 212 (ZNF212), mRNA 747 7898 11046 0.8 0 D30612.1 NT Homo saplens mRNA for repressor protein, partial cds 752 5904 11051 1.2 0 R4891 5.1 EST HUMAN yj69g08.M Soares breast 2NbHBst Homo sapiens cIDNA done IMAGE:1 54046 51 753 5905 11052 0.8 0 5032086 NT Homo sapiens splicing factor 3a, subunit 1, 120k13 (SF3A1), mRNA 14 11061 0,5 0 AB011399.1 NT Horno saplens gene for AF-6, complete cds 765 5918 11065 1.0 0 7661965 NT Homo sapiens KIAA0170 gene product (K1AA0170), mRNA - Page 169 of 196 Table 4

775 5927 11076 1.2 0 D80006.1 NT Human mRNA for KIAA01 84 gene, partial cds 775 5927 11077 1.2 0 D80006.1 NT Human mRNA for KIAA0184 gene, partial cds form) 780 5932 11081 0.9 0 X89772.1 NT H.sapiens mRNA for Interferon alphalbeta receptor (long 784 5936 11085 0.8 0 A13020717.1 NT Homo sapiens mRNA for KIAA0910 protein, partial cds 784 5936. 11086 0.8 0 AB020717.1 NT Horno sapiens mRNA for KIAA0910 protein, partial cds 789 5940 11092 2.3 0 5174478 NT Homo saplens pericentrin (PCNT) mIRNA 790 5941 2.4 0 4507500 NT Homo saplens T-cell lymphoma invasion and metastasis 1 (TIAM1) mRNA kinase (HUNK), mRNA 807 5958 11113 0.5 0 7657213 NT Homo sapiens hormonally upregulated neu tumor-associated 808 5959 11114 1.5 0 7657213 NT Homo sapiens hormonally upregulated neu tumor-associated kinase (HUNK), mRNA 810 5961 11116 1.3 0 4557686 NT Homo sapiens potassium voltage-gated channel, Isk-related family, member 1 (KCNE1) 816 5966 11122 1.2 0 AF108830.1 NT mRNA 816 5966 11123 1.2 0 AF108830.1 NT Homo saplens sedne-threonine protein kinase (MNBH) mRNA, complete cds Homo sapiens sedne-threonine protein kinase (MNBH) mIRNA, complete cds 821 5971 11128 1.1 0 4503854 NT Homo sapiens GA-binding protein transcription factor, alpha subunit (6OkD) (GABPA), mRNA 825 5974 11133 0.5 0 4507500 NT Homo saplens T-cell lymphoma Invasion and metastasis 1 (TIAM1) mRNA 825 5974 11134 0.5 0 4507500 NT Homo sapiens T-cell lymphoma Invasion and metastasis 1 (TIAM1) mRNA 832 5981 11145 0.5 0 AF0271153.1 NT Homo sapiens sodium/myMnositol cotransporter (SLC5A3) gen, complete cds 836 5985 1.2 0 A13028942.1 NT Homo sapiens mRNA for KIAA1019 protein, partial cds 836 5985 11146 1.2 0 A13028942.1 NT Homo sapiens mIRNA for KIAA1019 protein, partial cds 837 5986 11147 2.5 0 4507152 NT Homo sapiens SON DNA binding protein (SON) mRNA 838 5987 11148 1.0 0 A13028942.1 NT Homo sapiens mRNA for KIAA1019 protein, partial cds 839 5988 11149 0.7 5 4506728 NT Homo sapiens ribosomal protein S5 (RPS5) mRNA 843 5992 11152 1.3 0 A13020717.1 NT Homo sapiens mRNA for KIAA0910 protein, pardal cds 843 5992 11153 1.3 0 A13020717.1 NT Homo sapiens mRNA for KIAA0910 protein, partial cds 844 5993 11154 0.7 0 AA533272.1 EST-HUMAN nj66d07.sl CI_CGAP_PrlO Homo sapiens cDNA done IMAGE:997453 844 5993 11155 0.7 0 AA533272.1 EST-HUMAN n]66d07.sl NCI CGAP Pr11 0 Homo saplens cDNA done IMAGE:997453 849 5998 11156 1.3 0 7657213 NT Homo sapiens hormonally upregulated neu tumor-assodated kinase (HUNK), mRNA 849 5998 11157 1.3 0 7657213 NT Homo sapiens hormonally upregulated neu tumor-associated kinase (HUNK), mRNA 850 5999 11158 0.7 0 7657213 NT Homo sapiens hormonally upregulated neu tumor-associated kinase (HUNK), mRNA 850 5999 11159 0.7 0, 7657213 NT Homo saple s hormon "11 upregulated neu turnor-assoclated kinase (HUNK), mRNA 873 6021 11182 0.9 0 A1.163203.2 NT Homo sapiens chromosome 21 segment HS21 C003 880 6028 11187 0.6 0 BE089592.1 EST HUMAN QVO-BT0703-280400-21 1 -911 BT0703 Horno sapiens cDNA 880 6F28 11188 0.6 0 BE089592.1 EST-HUMAN QVO-BT0703-280400-21 1 -gl 1 BT0703 Homo sapiens cDNA 890 6038 11197 1.3 0 AL-163203.2 NT Homo sapiens chromosome 21 segment HS21C003 900 6047 2.5 0 4504958 NT Homo sapiens laminin receptor 1 (67kD, ribosornal protein SA) (LAMR1), mRNA 903 6047 1.1 0 4504958 NT Homo sapiens laminin receptor 1 (67kD, ribosomal protein SA) (LAMR1), mIRNA 904 6050 11205 0.5 0 AF089747.1 NT Homo sapiens alpha-l-andchymotrypsin precursor, mRNA, partial cds 905 6051 11206 1.0 0 S69354.1 NT pro In C Inhibitor [human, leukocytes, Genomic, 1216 nt, segment 2 of 53 905 6051 11207 1.0 0 S69364.1 NT protein C Inhibitor [human, leukocytes, Genomic, 1216 nt, segment 2 of 5) 905 6051 11208 1.0 0 S69364.1 NT protein C Inhibitor [human, leukoeytes, enomic, 1216 nt, segment 2 of 51 Page 170 of 196 Table 4

906 6052 11209 0.7 0 L28101.1 NT Horno saplens Icallistatin (P14) gene, exons 1-4, complete ccis 909 6055 11212 36.0 0 Z20656.1 NT Homo sapiens of cardiac alpha-m)"ln heavy chain gene 909 6055 11213 36.0 0 Z20656.11 NT Homo saplens of cardiac alpha-myosin heavy chain gene 910 6056 11214 57.0 0 Z20656.1 NT Homo sapiens of cardiac alpha-myosin heavy chain gene 910 6056 11215 57.0 0 Z20656.1 NT Homo sapiens of cardiac alpha-myosin heavy chain gene 935 6082 11238 12.0 0 M37190.1 NT Human ras Inhibitor mRNA, 3' end 936 6083 11239 4.5 0 M371 90.1 NT Human ras Inhibitor mRNA, Yend 937 6084 11240 18.0 0 M37190.1 NT Human ras Inhibitor mRNA, Y end 938 6085 11241 0.7 0 4507430 NT Homo sapiens thyrotrophic embryonic factor (TEF), mRNA 938 W85 11242 0.7 0 4507430 NT Homo sapiens thyrotrophic embryonic factor (TEF), mRNA 946 7903 11249 0.8 0 A1001948.1 EST-HUMAN os98e03.sl NCI CGAP_GC3 Homo sapiens cDNA done IMAGE:1613404 3' 946 7903 11250 0.8 0 A1001948.1 ESTHUMAN os98e03.sl NCl-WAP-GC3 Homo saplens cDNA done IMAGE:1613404 3' 948 6094 11252 2,5 0 7657266 NT Homo saplens KIAA0929 protein Msx2 Interacting nuclear target (MINT) homolog (K1AA0929), mRNA 968 6113 11271 1.3 0 X52207.1 NT Homo saplens partial c-fgr gene. exons 2 and 3 968 6113 11272 1.3 0 X52207.1 NT Horno sapiens partial cfgr gene. exons 2 and 3 977 6122 11279 1.3 0 4757969 NT Horno saplens chromodomain protein, Y chrornosome-like (CDYL) mRNA 988 6132 11287 1.1 0 U83668.1 NT Human beta-tubulin (TUB4q) gene. complete cds 989 6133 11288 2.6 0 U83668.1 NT Human beta-tubulln (TUS4q) gene, complete cds 990 6133 11288 2.3 0 U83668.1 NT Human beta-tubulin (TUB4q) gene. complete cds 997 613911293 0.8 0 AF1 11170.3 NT Horno sapiens 14g32 Jagged2 gene, omplete cds. and unknown gene 99W 6139 11293 1,4 0 AF111170.3 NT Homo sapiens 14g32 Jaggec12 gene, complete cds; and unknown gene 999 6139 11293 0.6 0 AF1 11170,3 NT Homo saplens 14g32 Jagged2 gene, complete cds, and unknown gene 1000 6140 11294 0.8 0 AF1 11170.3 NT Homo sapiens 14g32 Jagged2 gene, oomplete cds; and unknown gene 1003 6143 11297 0.8 0 7661685 NT Homo sapiens DKFZP586M0122 protein (OKFZ12586M0122), mRNA 1007 6147 11301 0.9 0 5803114 NT Homo sapiens i ner membrane protein, mitochonddal (mitofilin) (IMMT), mRNA 1009 6149 0.7 0 AA458680.1 EST HUMAN aa86g07.sl Stratagene fetal retina 937202 Homo, sapiens cDNA done IMAGE:838236 3' similar to SW:PRS8LI-11.1MAN P47210 26S PROTEASE REGULATORY SUBUNIT 8:

1012 6152 11306 1.0 0 N43182.1 EST-HUMAN EST51 124 WATM1 Homo sapiens cDNA done 51124 similar to DNA-DIRECTED RNA POLYMERASE 11 (alignment Ser and Pro Wth MSTx or p) 1012 6152 11307 1.0 0 N43182.1 EST HUMAN EST51124 WATM1 Homo, sapiens cDNA done 51124 similar to DNA-DIRECTED RNA POLYMERASE 11 (alignment Ser and Pro vAth BLASTx or p) 1013 6153 11308 1.0 0 4759249 NT Homo sapiens TRAF family member- associated NFKB activator (TANK) mRNA 1013 6153 11309 1.0 0 4759249 NT Homo, saplens TRAF family memberassociated NFKB activator (TANK) mRNA 1017 6157 1.5 0 8922933 NT Homo sapiens hypothetical protein FLA 1196 (FU1 1 196y, mRNA 1031 6171 11324 0.8 0 4758569 NT Horno sapiens heat shock 7OkD protein 9B (mortalin-2) (HSPA913) mRNA 1049 6188 11339 0.6 0 4826672 NT Homo sapiens cadhedn 6, K-mdhedn (fetal kidney) (CDH6) mRNA 1049 6188 11340 0.6 0 4826672 NT Homo saplens cadhedn 6, K--adhedn (fetal kidney) (CDH6) mRNA 1053 6192 11344 0.9 0 8923624 NT Homo sapiens hypothetical protein FLJ20695 (FLJ20695), mRNA 1053 61W 11345 0.9 0 8923624 NT)lens hypothetical protein FLJ20695 (FLJ20695), mRNA 1054 6193 11346 3.0 0 1.1AKGI)13.4)lens mRNA for alpha-tubulin 8 (TUBA8 gene) IS G.

Page 171 of 196 Table 4

1056 6195 0.9 0 8923087 NT Homo sapiens hypothetical protein FU20080 (FU20080), mRNA 1058 6197 11350 1.1 0 5174384 NT Homo sapiens alkylation repair; alkB homolog (ABH), mRNA 1066 6204 11359 1.2 0 4758117 NT Homo sapiens Death associated protein 3 (DAP3) mRNA 1080 6218 11369 1.2 0 BE005208.1 EST-HUMAN MRO-BN01 15-200300-003-h08 BN01 15 Homo sapiens cDNA 1103 6241 11393 1.3 0 7706134 NT Homo sapiens potassium channel, subfamily K, member 9 (KiCNK9), mRNA 1103 6241 11394 1.3 0 7706134 NT Homo sapiens potassium channel, subfamily K, member 9 (KCNK9), mRNA 1116 6253 11404 1.1 0 4826947 NT Homo saplens protein kinase, X-linked (PM) mRNA 1116 6253 11405 1.1 0 4826947 NT Horno saplens protein kinase, X-linked (PM) MRNA 1117 6254 11406 1.9 0 4506712 NT Homo sapiens ribosomal protein S27a (RPS27A) mRNA 1119 6256 11408 0.9 0 8923290 NT Homo saplens hypothetical protein FU20309 (FU20309), mRNA 1121 6258 11410 3.5 0 AB002059.1 NT Homo saplens DNA for Human P2XM, complete cds 1123 6260 11411 4.1 0 A13002059.1 NT Homo saplens DNA for Human P2XM, complete cds 1124 6261 11412 0.7 0 7657468 NT Homo sapiens similar to rat Integral membrane glycoprotein POM1 21 (POM1 21 Ll), mRNA 1124 6261 11413 0.7 0 7657468 NT Homo sapiens similar to rat Integral membrane glycoproteln POMI 21 (POM1 21 Ll), mRNA 1128 6264 11416 1.0 0 7706500 NT Homo sapiens Npw38-binding protein NpwBP (LOC51729), mRNA 1129 6265 11417 1.0 0 A1147650.1 EST HUMAN qb22d10.xl Soares_pregna nt- uterus-NbHPU. Homo sapiens cDNA clone IMAGE:1 697011 X 1131 6267 11419 1.4 0 AB020710.1 NT Homo saplens mRNA for KIAA0903 protein, partial cds 1152 6287 11440 0.8 0 7305076 NT Homo sapiens glutamate decarboxylase 1 (brain, MD) (GAD1), transcript variant GAD25.

mRNA 1152 6287 11441 0.8 0 7305076 NT Homo sapiens glutamate decarboxylase 1 (brain, 67kD) (GAD1), transcript variant GAD25, mRNA 1154 6289 11443 0.5 0 A13037835.1 NT Homo sapiens mRNA for KIAA1414 protein, partial cds 1161 6296 11452 1.0 0 4557887 NT Homo saple s keratin 18 (KIRT18) mRNA 1191 6323 1.1 0 7657336 NT Homo saplens mutL (E. coli) homolog 3 (MLH3), mRNA 1206 6338 11494 1.1 0 AF264750.1 NT Honno sapiens ALR-like protein mRNA, pardal ods 1206 6338 11495 1.1 0 AF264750.1 NT Homo saplens ALR-like protein mRNA, partial cds 1207 6339 11496 1.3 0 AF264750.1 NT Homo sapiens ALR-like protein mRNA, partial cds 1208 7909 11497 1.0 0 AF264750.1 NT Homo saplen ALR-like protein mRNA, partial cds 1226 6356 11520 3.6 0 AF1 09718.1 NT Homo sapiens chromosome 3 subtelomeric region 1227 6357 11521 1.3 0 4503098 NT Homosapiens chondrolfin sulfate proteoglycan 4 (melanoma-associated) (CSPG4), mRNA 1245 6374 1.5 0 Y118000.1 NT Homo sapiens NF2 gene 1253 6382 11541 16.0 0 4506718 NT Homo saple s dbosomal protein S2 (RPS2) mRNA 1260 6389 _11550 1.3 0 AF084479.1 NT Homo sapiens Williams-Bcuren syndrome deletion transcript 9 (WBSCR9) mRNA, complete cds 6395 11554 0.6 0 AB040940.1 NT Homo saplens mRNA for KIAA1507 protein, partial cds 6395 1155 0 A13040940.1 NT Homo sapiens mRNA for K1AA1 507 protein, partial cds 6408 11568 2.2 0 5174748 NT Homo sapiens Wolfram syndrome (WFS) mRNA Page 172 of 196 Table 4

1278 6408 11569 2.2 0 5174748 NT Homo sapiens Wolfram syndrome (WIFS) mRNA 1278 6408 11570 2.2 0 5174748 NT Horno sapiens Wolfram syndrome (WFS) mRNA 1279 6409 0.9 0 AF096156.1 NT Horno sapiens protein phosphatase 2A BR gamma subunit gene, exon 5 1289 7911 11582 1.1 0 7657529 NT Homo saplens rhabdoid tumor deletion region protein 1 (RTDR1), mRNA 1289 7911 11583 1.1 0 7657529 NT Horno saplens rhabdold tumor deletion region protein 1 (RTDR1), mRNA 1295 6424 11589 0.6 0 5803146 NT Homo saplens ring finger protein 9 (RNF9), mRNA 1296 6425 11590 0.8 0 4508004 NT Horno sapiens Anc finger protein 173 (ZNF173) mRNA 1298 6427 11591 1.1 0 5803146 NT Horno saplens ring finger protein 9 (RNF9), mRNA 1300 6429 11593 1.4 0 AB01 1149.1 NT Homo saplens mRNA for KIAA0577 protein, complete cds 1301 6430 11594 1.1 0 7661965 NT Homo saplens KIAA01 70 gene product (K1AA01 70), mRNA 1302 6431 11595 1.6 0 7661965 NT Homo sapiens KIAA0170 gene product (K1AA0170), mRNA 1303 6432 11596 1.4 0 8567387 NT Homo sapiens period (Drosophila) homolog 3 (PER3), mRNA 1303 6432 11597 1.4 0 8567387 NT Homo sapiens period (Drosoghlia) homolog 3 (PER3), mRNA 1315 6443 11610 1.4 0 M14123.1 NT Human endogenous retrovirus HERM10 1386 6513 11679 0.9 0 AJ250014.1 NT Homo saplens mRNA for Familial Cylindromatosis cyid gene 1393 6520 11688 3.3 0 AJ277892.1 NT Homo sapiens partial TTN gene for titin 1396 6523 11692 1.0 0 A1208756.1 EST HUMAN q938b06.xl Soares-testis-NHT Homo sapiens cDNA done IMAGE:1837427 Ysimilar to WRT27A1.5 CE14213; 1397 6524 11693 3.0 0 6042206 NT RAN, member RAS oncogene familyHomo sapiens RAN, member RAS oncogene family (RAN), mRNA 1407 6534 11705 0.5 0 4505646 NT Homo sapions proproteln convertase subblisinlke)dn type 2 (PCSK2) mRNA 1407 6534 11706 0.5 0 4505646 NT Homo sapi ns proprotein convertase subdilsinlkeyJn type 2 (PCSK2) mRNA 1409 653-6 11709 0.9 0 7705565 NT Horno saplens K1AA1 114 protein (K1AA1 114), mRNA 1409 6536 11710 0.9 0 7705565 NT Homo saplens K1AA1 114 protein (K1AA1 114), mRNA 1412 6539 11712 1.9 0 AJ238093.1 NT Homo saplens partial AF-4 gene, exons 2 to 7 and AM repeat elements 1421 6549 11724 1,3 0 AF038280.1 NT Homo saplens alphd I - 6fucosyitransferase (alphal6FucT) gene, exon 7 1432 6559 11735 3.5 0 4507720 NT Homo sapiens tifin (TTN) mRNA 1432 6569 11736 3,5 0 4507720 NT Homo sapiens Ubn (TTN) mRNA 1437 6564 11740 1.0 0 U35637.1 NT Human nebulin mRNA, partial ccis 1437 6564 11741 1.0 0 U35637.1 NT Human nebulin mRNA, partial ccis 1445 6572 11746 1.1 0 AL132999.1 NT Novel human gene on chromosome 20 1447 6574 11747 1.0 0 AL137764.1 NT Novel human gene mapping to chomosome 1 1451 6578 11752 1.2 0 D87077.1 NT Human mRNA for KIAA0240 gene, pardai_cds 1454. 6581 11755 1.8 0 6912457 NT Homo sapiens caldneurin binding protein 1 (K1AA0330), mRNA 1456 6563 11757 0.6 0 7661965 NT Homo sapiens KM0170 gene product (K1AA0170), mRNA 1456 6583 11758 0.6 0 7661965 NT Homo sapiens KIAA0170 gene product (K1AA0170), mIRNA 1457 6584 1.0 0 Y07829.2 NT Horno saRiens RFB30 gene for RING finger protein 1462 6589 11763 1.3 0 M60676.11 NT Human von Willebrand factor pseudogene corresponding to exons 23 through 34 1462 6589 11764 1.3 0 M60676.1 NT Human von Willebrand factor Oseudogene ooffesponding to exons 23 through 34 1495 6621 11791 1.3 0 7706434 NT Homo sapiens hHDC for homolog of Drosophila headcase (LOC51696), mRNA 1509 6636 11805 1.0 0 AA481172.1 EST---HUMAN aa34a03.rl NCI CGAP GC131 Homo sapiens cIDNA done IMAGE:815116 5' C--\ -3L C Page 173 of 196 Table 4

Page 174 of 196 1515 6642 11808 4,3 0 AF023860.1 NT Cercopithecus aethlops cyclophilin A mRNA, complete cds 1515 6642 11809 4.3 0 AF023860.1 NT Cercopithecus aethiops cyclophilin A mRNA, complete cds 1517 6644 11812 1.0 0 D10884.1 NT Bovine mRNA for nourocalcin- 1519 6646 0.7 0 U78027.1 NT Homo sapiens Bruton's tyrosine kinase (BTK), alpha-D-galactosidase A (GLA), L44-like dbosomal protein (L441---)and FTP3 (FTP3) genes, complete cds 1520 6647 11815 3,9 0 4505404 NT Homo saplens transmembrane glycoprotein (GPNMB) mRNA 1520 6647 11816 3,9 0 4505404 NT Homo sapiens transmembrane glycoproteln (GPNMB) mRNA 1521 6648 11817 1.1 0 7662405 NT Homo sapiens KIAA0957 protein (K1AA0957), mIRNA 1522 6649 3.0 0 7656972 NT Homo sapiens TWAnducible protein CG12-1 (CG12- 1), mRNA 1527 6654 11821 1.8 0 M98478.1 NT Human transgiutaminase mRNA, complete ods 1530 6F577 11823 2.1 0- 4507720 NT Homo sapt ns ddn (TTN) mRNA 1530 6657 11824 2.1 0 4507720 NT Homo sapiens fifin (TTN) mRNA 1531 7919 10.1 0 4506654 NT Homo saplens dbosomal protein L5 (RPL5) mRNA 1532 6658 11825 4.0 0 M14199.1 NT Human laminin receptor (21-15 epitope) mRNA. Yend 1541 6668 11838 2.1 0 4507720 NT Homo saplens fifin (TTN) mRNA 1541 6668 11839 2,1 0 4507720 NT Homo sapi ns litin (TTN) mRNA 1543 6670 11840 4.7 0 4503098 NT Horno sapiens chondroifin sulfate proteoglycan 4 (melanoma-associated) (CSPG4), mRNA 1562 6689 11857 0.6 0 Z83738.1 NT H.sapiens hH2B/e gene 1563 6690 11858 1.4 0 5921460 NT Homo saplens butyrophiiin, subfamily 2, member AI (STN2A1), mRNA 1563 6690 11859 1.4 0 5921460 NT Homo sapiens butyrophilin, subfamily 2, member A1 (BTN2A1), mRNA 1566 7920 11862 0.5 0 A13040905.1 NT Horno sapiens mRNA for KIAA1472 protein, partial cds 1570 6696 11863 1.0 0 AF157476.1 NT Homo sapi ns DNA polymerase zeta catalytic subunit (REV3) mRNA, complete cds 1572 6698 11866 0.9 0 7662183 NT Homo sapiens KIAA0569 gene product (K1AA0569), mRNA 1572 6698 11867 0.9 0 7662183 NT Homo sapiens KIAA0569 gene product (K1AA0569), mRNA 1574 670-0 11868 5.1 0 5729876 NT Homo sapi ns beat shock 70W protein 10 (HSC71) (HSPA10), mRNA 1574 6700 11869 5,1 0 5729876 NT Horno sapiens heat shock 70ki) protein 10 (I-ISC71) (H5PA10), mRNA 1576 6762 11871 0.9 0 M91803.1 NT Human sodium channel mRNA 1591 6717 11687 1.7 0 H26973.1 EST HUMAN yo76c05.si Soares adult brain N2b41-11355Y Homo sapiens cDNA clone IMAGE: 183848 3' 1645 6771 11942 1.3 0 A1768104.1 EST HUMAN wg81b07.xl Soares_NSF-F8- 9VV_QT^_P_S1 Homo sapiens cDNA clone IMAGE:2371477 3' similar to TR:Q62788 Q62788 CYS2/HiS2 ZINC FINGER PROTEIN.

1646 6772 11943 1.2 0 AF057177.1 NT Homo saplens T-cell receptor gamma V1 gene region 1650 6775 11947 0.6 0 M29580.1 NT Human zinc-finger protein 7 (WP7) mRNA, complete cds 1650 6775 11W 0.6 0 M29580.1 NT Human zinc-finger protein 7 (ZFP7) mRNA, complete ods 1652 6717 11950 1.2 0 4557887 NT Homo saplens keratin 18 (KRT1 8) mRNA 1653 6778 11951 0.9 0 7657065 NT Homo sapiens v-ets avian erythroblastosis virus E26 oncogene related (ERG), mRNA 1657 6781 1195 1,1 0 4557610 NT Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABIRG2) mRNA 1659 6783 11958 1.1 0 H30132.1 EST_HUMAN - yo59e08xl Soares breast 3NbHBst Homo, saplens cIDNA done IMAGE:182246 Csimilar to gb:M64099 GAMMA-GLUTAMYLTRANSPEPTIDASE 5 PRECURSOR (HUMAN); Table 4

Page 175 of 196 1659 6783 119591 1.1 0 H30132.1 EST HUMAN Y059e0C1 Scares breast 3NbHBst Homo sapiens cDNA done IMAGE:182246 5'similar to Qb:M64099 GAMMA-GLUTAMYLTRANSPEPTIbASE 5 PRECURSOR (HUMAN); 1661 6785 11961 1.2 0 Z80780.1 NT H.sapiens H2131h gene 1661 6785 11962 1.2 0 Z80780.1 NT H.sapiens H2131h gene 1654 6788 11974 2.8 0 5031748 NT Homo sapiens high-mobility group (nonhistone chromosomal) protein 17 (HMG17), mRNA 1672 6796 11980 1.6 0 8923841 NT Homo sapiens FOXJ2 forkhead factor (C0C55810), mRNA 1677 6801 11981 1.0 0 M75980.1 NT Human hep tocyte growth factor gene, exon 15 1677 6801 -1.0 0 M75980.1 NT 11 Human hepatocyte growth factor gene, exon 15 Homo saplens RNA binding motif protein, Y chromosome, family 1, member AI (R13MY1A1) 1680 6804 11985 0.5 0 4826973 NT mRNA 1685 6809 11992 0.9 0 AB026542,1 NT Homo sapiens WAVE2 mRNA for WASP- faMly protein, complete cds 1687 6811 12049 0.9 0 S94400.1 NT TCR zeta [human, Genornic/mRNA, 365 nt, segment 1 of 81 1745 7925 5.0 0 4506718 NT Homo saplens dbosoma]12!in S2 (RPS21mRNA 1749 6871 0.9 0 4557556 NT Homo saplens E1A binding protein p300 (EP300) mRNA roteln p300 (EP300) mRNA 749 6871 12050 0.9 0 4557556 NT Homo sapiens EIA binding complete cds, and (SMF) gene, partial cds 1751 6873 12053 1.2 0 U63963.1 NT Human CSFA receptor (FMS) gene, 1754 6876 12057 1.1 0 W76571.1 EST-HUMAN zd66909.rl Soares-fetaLbeart- NbHHI9W Horno sapiens cDNA clone IMAGE:345664 5' 11755 7926 12070 1.4 0 4505332 NT Homo sapiens; nuclear autoandgenic sperm protein (histone-binding) (NASP) mRNA 1765 6886 2.6 0 U14967.1 NT Human ribosomal protein L21 mRNA, complete cds KIAA0333 partial cds 1767 6888 12073 1.7 0 A13002331.1 NT Human mRNA for gene, transcription factor 4 (tax-responsive enhancer element B67) (ATF4) Homo, saplens activating 1768 6889 12074 1.6 0 4502264 NT mRNA Homo sapiens activating transcription factor 4 (tax-responsive enhancer element 1367) (ATF4) 1768 6889 12075 1.6 0 4502264 NT mRNA Homo saplens activating transcription factor 4 (tax-responsive enhancer element B67) (ATF4) 1768 6889 12076 1.6 0 4502264 NT mRNA Homo sapiens immunoglobin superfamily, member 3 (IGSF3) mRNA, and translated 1781 6902 12090 1.0 0 4504626 NT products Homo sapiens lmmunoglobin superfamily, member 3 (IGSF3) mRNA, and translated 1781 6902 12091 1.0 0 4504626 NT products 1793 6913 12098 3.7 0 6005855 NT Horno sapiens Retina-derived POU-domain factor-l. (RPRNA Retina-derived POU-domain factor-1 (RPF-1), mRNA 1793 6913 12099 3.7 0 6005855 NT Homo sapiens channel, Shab-relat subfamily, member 1 Homo sapiens potassium voltage-gated 1804 6923 12108 1.2 0- 4826783 NT (KCNBI) mRNA Homo saplens potassium voltage-gated channel. Shab-related subfamily, member 1 1804 6923 12109 1,2 0 4826783 NT (KCNBI) mRNA 1805 6924 12110 1 0 U07147.1 NT Human refinal degeneration slow (RDS) gene, exon 1 1805 6924 12111 F-1.6 0 U07147.1 NT Human rednal degeneration slow (RDS) gene, exon 1 Table 4

1809 6928 12116 0.5 0 AW207280.1 EST-HUMAN Ul-H-Bil-afn-f-07-0-Ul.sl NCICGAP-Sub3 Honno sapiens cIDNA clone IMAGE:2722333 3, 1809 6928 12117 0,5 0 AW207280.1 EST HUMAN Ul-H-Bil-afn-f-07-0-Ul.sl NCI CGAP_Sub3 Homo sapiens cDNA clone IMAGE:2722333 3, 1832 6951 12135 0.8 0 SE277465.1 EST HUMAN 601179164F1 NIH_MGQ_20 Homo sapiens cDNA done IMAGE:3547239 5' 1832 6951 12136 0.8 0 BE277465.1 EST HUMAN 601179164F1 N11-1 MGC 20 Homo sapiens cDNA done IMAGE:3547239 5' 1852 6970 12155 1.0 0 BE006292.1 EST-HUMAN RC2-BN0126-200300-012-b04 BN0126 Horno sapiens cIDNA 1881 6999 12183 1.3 0 4506384 NT Homo sapiens RAD1 (S. pombe) homolog- MD71) mRNA, and translated products 1881 6999 12184 1.3 0 4506384 NT Homo sapiens RADI (S. pombe) homolog (RAD1) mRNA, and translated products 1689 7007 0.6 0 AF1157476.1 NT Homo sapiens DNA polymerase, ieta catalytic subunit (REV3) mRNA, complete cds 1890 7929 12193 1,5 0 M98478.11 NT Human transgiutaminas mRNA, complete cds 1890 7929 12194 1.5 0 M98478.11 NT Human transgiutaminase mRNA, complete cds 1895 7012 12201 0.8 0 4507464 NT Homo sapiens transforming growth factor, beta 3 (TGFB3), mRNA 1895 7012 12202 0.8 0 4507464 NT Homo saplens transforming growth factor, beta 3 (TGFB3), mIRNA 1903 7021 0.7 0 M55632.1 NT Human topolsomerase 1 pseudogene 1 1905 7930 12210 0.9 0 5901905 NT Homo sapiens butpophilin, subfamily 3, member A2 (BTN3A2), mRNA 1913 7030 12217 0.7 0 4809282 NT Homo sapiens hisfidine ammonia-lyase (HAL) mRNA 1913 7030 12218 0.7 0 4809282 NT Homo sapiens hisfidine ammonia-lyase (HAL) mRNA 1924 7041 1.1 0 AL1 63252.2 NT Homo saplens chromosome 21 segment HS21 C052 1926 7043 12232 1.2 0 8400716 NT Horno sapiens nebulin ( EB), mRNA 1926 7043 12233 1.2 0 8400716 NT Homo sapiens nebulin (NEB), mRNA 1927 7044 12234 2.9 0 4826638 NT Homo sapiens actinin, alpha 4 (,ACTN4) mRNA 1927 7044 12235 2.9 0 4826638 NT Homo saple s actinin, alpha 4 (ACTN4) mRNA 1937 7054 12247 1.2 0 AB018333.1 NT Homo sapiens mRNA for KIAA0790 protein, partial cds 1937 7054 12248 1.2 0 AB0118333.1 NT Homo sapiens mRNA for KIAA0790 protein, partial cds 1943 7060 12252 0.7 5 M33782.11 NT Human TFEB protein mRNA, partial cds 1943 7060 12253 0.7 0 M33782.11' NT Human TFEB protein mRNA, partial cds 1945 7062 12254 1.3 0 AW193024.1 EST HUMAN W69b011.xl NCI CGAP_Panl Homo sapiens cDNA clone IMAGE:2679913 3' 1945 7062 12255 1.3 0 AW193024.1 EST HUMAN A69b01.xl NCI_PGAP-Panl Homo sapiens cIDNA done IMAGE:2679913 3' 1946 7063 12256 3.0 0 6912457 NT Horno sapiens caldneurin binding protein 1 (K1AA0330), mIRNA 1946 7063 12257 3.0 0 6912457 NT Homo saplens caldneurin binding protein 1 (K1AA0330), mRNA 1948 7065 12259 0.9 0 Z47556.1 NT H.sapiens genes for semenogelin 1 and semenogelin 11 1948 7065 12260 0.9 0 Z47556.11 NT H.saplens genes for semenogelin 1 and semenogelin 11 1955 7072 12269 0.8 0 AB040946.11 NT Horno sapiens mIRNA for KIAA1513 protein, partial cds 2011 7125 12325 1.1 0 4557887 NT Homo saplens keratin 18 (KIRT118) mRNA 2011 7125 12326 1.1 0 4557887 NT Homo sapie s keratin 18 (KIRT1 8) mRNA 2013 7127 12327 1.0 0 4503648 NT Homo saplens coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) (F9) mIRNA 2014 7128 12328 2.0 0 4 05606 NT Homo sapiens pregnancy-assodated plasma protein A (PAPPA) mRNA 2015 6536 11709 1.0 0 7705565 NT Homo saplens K1AA11 114 protein (K1AA1 114), mIRNA 2015 6536 11710 1.0 0 7705565 NT Homo saRiens K1AA11 114 protein (K1AA1 114), mIRNA Page 176 of 196 ' Table 4

2017 7130 12330 0.7 0 AA077589.1 EST-HUMAN 7B22E10 Chromosome 7 Fetal Brain cDNA Library Homo sapiens cDNA done 7B22E10 2017 7130 12331 0.7 0 AA077589.1 EST HUMAN 7B22E10 Chromosome 7 Fetal Brain cIDNA Library Homo sapiens cDNA done 7B22E10 2019 7132 0.9 0- 7657468 NT Homo sapiens similar to rat integral membrane glycoprotein POM121 (POM1211-1), mRNA 2021 7134 0.6 0 4585863 NT Homo sapiens phosphodlesterase 6A, cGMP- specific. rod, alpha (PDE6A), mRNA 2022 7135 12334 0.9 0 AF124250.1 NT Homo saplens SH2-containing protein Nsp2 mRNA, complete cds 2024 7137 0,7 0 A1244247.1 EST - HUMAN qv9OfO8.xl NCLCGAP_Ut2 Homo saplens cDNA clone IMAGE:1988871 Ysimilar to contains AW repetitive element; 2029 7142 12343 0.9 0 X92841.1 NT H.saplens MICA gene 2031 7144 12345 0.5 0 BE326593.1 EST_HUMAN hr62a08.xl NCI-CGAP_Kidl 1 Homo sapiens cIDNA clone IMAGE:3133046 Ysimilar to TR.P97307 P97307 SIDIF2.; 2031 7144 12346 0.5 0 BE326593.1 EST HUMAN hr62a08.xl NCI_PGAP-WII 1 Homo sapiens cDNA done IMAGE:3133046 3' similar to TR:P97307 P97307 SIDF2.; 2035 7148 12351 0.9 0 7662007 NT Homo sapiens KIAA0218 gene product (K1AA0218), mRNA 2036 7148 12352 0.9 0 7662007 NT Homo saplens KIAA0218 gene product (K1AA0218), mRNA 2040 7153 12358 0.9 0 4757807 NT Homo sapiens ATPase, Ca++ transporting, plasma membrane 2 (ATP2B2) mIRNA 2040 7153 12359 0.9 0 4757807 NT Homo sapiens ATPase, Ca++ transporting, plasma membrane 2 (ATP2B2) mIRNA 2045 7158 12363 1,3 0 4758489 NT Homo sapiens GT12 binding protein 1 (GTPBPI) mIRNA 2067 7179 1.0 0 U90552.11 NT Human butyrophilin (BTF5) mRNA, complete cds 2068 7180 1.1 0 AF018963.1 NT Homo sapiens X-linked juvenile refinoschisis protein (XLIRS1) gene, exon 6 and complete ods 2070 7182 12386 1,1 0 U54777.2 NT Homo sapiens hMSH6 protein (MSH6) mRNA, complete cds 2071 7183 12387 0.7 0 4503756 NT Homo saplens flavin containing monooxygenase 2 (FIVI02) mRNA 2074 7186 12389 1.2 0 AW752708.1 ES-_HUMAN IL3-CTO219-27109M22-GIO CTO219 Homo saplens cDNA 2076 7188 12391 0.7 0 _ EST HUMAN W-BTOIS"2039"92 BT065 Homo saplens cDNA A1904640.1 2076 7188 12392 0.7 0 A1904640.1 EST_HUMAN QV-BT065-020399-092 BT065 Homo saplens cDNA 2112 7223 1.2 0 7657252 NT Homo saplens potassium large conductance caldum-activated channel. subfamily M, beta member 3-like (KCNMB3L), mIRNA 2132 7242 0.6 0 L14787.1 NT Human DNA-binding protein mRNA, Yend 2138 7248 12454 1.0 0 BE274696.1 EST_HUMAN 601122338F1 NIM IVIG2.20 Homo sapiens cIDNA done IMAGE:3346688 9 2140 7250 12457 1.1 0 7662017 NT Horno sapiens KIAA0244 protein (K1AA0244), mRNA 2141 7251 12458 3.8 0 AB015610.1 NT Chlorocebus aethlops mRNA for ribosomal protein S4X, complete cds 2141 7251 12459 3.8 0 A8015610.1 NT Chlorocebus aethlops mRNA for dbosomal protein S4X, complete cds 2143 7253 12461 0.5 0 7661569 NT Horno sapiens DKFZP434D156 protein (DKFZP434D156), mRNA 2145 7255 0.9 0 M19828.1 NT Human apolipoprotein B-100 (apoB) gene, exons 22 through 29 2148 558 12465 6.2 0 Y18552.11 NT Horno sapiens HI-A-BEInull gene 2149 7259 12466 4.1 0 4506648 NT Horno sapiens dbosomal protein L3 (RPL3) mRNA 2152 7262 12469 0.9 0 U21556.1 NT Human membrane protein-like protein mRNA, partial cds 2152 7262 12470 0.9 0 U21556.1 NT Human membrane proteln41ke protein mRNA, partial cds 2156 79.36 12475 0.6 0 AF044962.1 NT Homo sapiens polio virus related protein 2 gene, exon 2 Page 177 of 196 Table 4

2159 7268 12478 0.7 0 BE0118750.1 EST-HUMAN bb84e02.y11 NIM_MGQ_10 Homo sapiens cDNA done IMAGE:3049082 Tsimilar to TR:Q15170 Q15170 TRANSCRIPTION FACTOR S-II-RELATED PROTEIN; 2160 7269 12479 0.9 0 AA042813.1 EST-HUMAN zk53c07.sli Soares_pregnant- uterus-NbHPU Homo sapiens cDNA clone IMAGE:486540 3' similar to gb:X65857odsl OLFACTORY RECEPTOR-LIKE PROTEIN HG1VIP07E (HUMAN); 2160 7269 12480 0.9 0 AA042813.1 EST-HUMAN zk53c07.sli SoareMregnantuterus-NbHPU Homo sapiens cDNA clone IMAGE:486540 X similar to gb:X65857cdsl OLFACTORY RECEPTOR-LIKE PROTEIN HG1VIP07E (HUMAN); 2168 727 12488 0.8 0 AL163204.2 NT Homo sapiens chromosome 21 segment HS21C004 2168 7277 12489 0.8 0 AL1 63204.2 NT Homo sapiens chromosome 21 segment HS21 C004 2169 7278 12490 1.0 0 7662401 NT Homo sapiens KIAA0952 protein (K1AA0952), mRNA 2169 7278 12491 1.0 0 7662401 NT Homo saplens KIAA0952 protein (K1AA0952), mRNA 2174 7283 1.0 0 U36264.1 NT Human beta-prime-adaptIn (BAM22) gene, exon 16 2193 7302 12516 2.7 0 4557556 NT Homo sapiens E1A binding protein p300 (EP300) mRNA 2199 7308 12520 0.5 0 7662401 NT Homo saplens KIAA0952 protein (K1AA0952), mRNA 2206 7315 12528 1.1 0 AB0231 95.1 NT Homo sapiens mRNA for KIAA0978 protein, partial ods 2209 7318 12531 0.9 0 7661965 NT Homo saplens KIAA0170 gene product (K1AA01170), mRNA 2209 7318 12532 0.9 7661965 NT Homo sapiens KIAA01 70 gene product (K1AA01 70), mRNA 2212 7320 12534 1.4 0 A13037784.11 NT Homo sapiens mRNA for K1AA1 363 protein, partial cds 2254 7360 12568 0.9 0 A1076404.1 EST-HUMAN ozO9cO7.xl Soares_fetal- tiverl_spie6n_l INIFI-S_S1 Homo sapiens cIDNA clone IMAGE: 1674828 3' 2256 7362 12570 0,8 0 AA429001.11 EST-HUMAN zv78al 1.rl Soares_total- fetus_N1J2HFfiL9w Homo sapiens cIDNA done IMAGE:759740 5' 2256 7362 12571 0,8 0 AA429001.11 EST HUMAN zv78al I.rl Soares-totai-fe. tus-Nb2HFQ_gw Homo sapiens cIDNA clone IMAGE.759740 5' 2258 7364 12573 0.8 0 AJ010230.1 NT Homo sapiens RET fing r r-oPej;:ii; i; nusense transcript, partial 2263 7369 12579 1.2 0 4826783 NT Homo sapiens potassium voltage-gated channel, Shab-related subfamily, member 1 (KCNB1) mRNA 226.4 7370 12580 0.7 0 6325466 NT Homo sapiens flavin containing monooxygenase 3 (FIVIO3), mRNA 2271 7377 12586 1.0 0 A1.347926.1 EST HUMAN gp60f09.xl NCI CGAP Co8 Homo sapiens cDNA done IMAGE: 1927433 3' 2274 7380 12588 3.7 0 AF0445711.1 NT Horno sapiens phosphorylase kinase alpha subunit (PHIKA2) gene, exon 32 2275 7381 12589 -1.0 0 A1625542.1 EST HUMAN ty57c08.xl NCI CGAP U1:2 Horno sapiens cIDNA done IMAGE:2283182 3' 2280 7386 12593 0.6 0 5803178 NT Horno sapiens sperm specific antigen 2 (SSFA2), mRNA 2280 7386 12594 0.6 0 5803178 NT Horno, sapiens sperm specific andgen 2 (SSFA2), mRNA 2291 7395 12604 1.5 5 AF058332.11 NT Homo sapi ns titin (TTN) gene, alternative splice products, pgrfiaf cds 2291 7395 12605 1.5 0 AF058332.1 NT Homo sapiens fifin (TTN) gene, alternative splice products, partial cds 2300 7404 12611 1.0 0 5174678 NT Homo sapiens signal regulatory protein, beta. 1 (SIRP-BETA-1) mRNA 2304 7407 12615 0.6 0 AF2463021 NT Homo sapiens peroxtisome proliferative activated receptor delta (PPARD) gene, exons 7 and 8 2305 7408 2.1 0 4506596 NT Homo sapiens dbosomal protein L1 2 (RPL1 2) mRNA 74091 2306 12616 1 ' 0 0 AW867076.1 EST HUMAN MR1-SNO033-120400-002-a04 SNO033 Homo sapiens cIDNA v 1 Page 178 of 196 Table 4

2307 7410 12617 0.7 0 7662017 NT Homo sapiens KIAA0244 protein K1770-244), mIRNA 2308 7411 12618 0.5 0 475B497 NT Horno saplens hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (H6PD), mRNA 2308 7411 12619 0,5 0 4758497 NT Homo saplens hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (H6PD), mIRNA 2310 7413 12620 2.7 0 4505332 NT Homo sapiens nuclear autoandgenic sperm protein (histone-binding (NASP) mRNA 2310 7413 12621 2.7 0 4505332 NT Horno saplens nuclear autoondgenic spenn protein (histone-binding) (NASP) mRNA 2310 7413 12622 2.7 0 4505332 NT Homo sapiens nuclear autoandgenic sperm protein (histone-binding) (NASP) mIRNA 2327 7430 1.0 0 8922550 NT Homo saplens hyE2!efical protein FLJ10618 (FLA0618), mIRNA 2366 7468 1.3 0 AF012872.1 NT Homo sapi ns phosphaddyfinositol 4-kinase 230 (p14K230) mRNA, complete cds 2369 7471 12673 1.0 0 AW303998.1 EST HUMAN M 5f07.xl SoaresNFLT_GBC_Sl Homo sapiens cIDNA done IMAGE:2813221 Ysimilar to TR:054924 054924 EX084.; 2382 7484 0.6 0 AF056332.1 NT Homo saplens AK2B processed pseudogene 2386 7487 12690 2.0 0 6006002 NT Homo saplens glutamate receptor, lonotroplc, N-methyl D-aspartate 2A (GRIN2A) mIRNA 2390 7490 12694 0.9 0 D85606.1 NT Homo sapiens gene for cholecystokinin We-A receptor, complete cds 2390 7Z90 12695 0.9 0 D85606.1 NT Homo sapiens gene for cholecystokfnin type-A receptor, complete ods 2398 7498 12704 0.8 0 AF106275.1 NT Homo saplens immunoglobutin-like transcript 1 c variant 4 (ILT1c) gene, exon 6 2410 7W9 12717 1.4 -0 5729777 NT Homo sapiens collagen, type X11, alpha 1 (COL12A1), mRNA 2414 7513 12720 0.9 0 4507280 NT Homo saplens serineithreonine kinase 9 (STK9) mIRNA 2414 751-3 12721 0.9 0 4507280 NT Homo saplens sedneithreonine kinase 9 (ST1K9) mIRNA 2419 7518 12725 0.8 0 4557887 NT Homo saplens keratin 18 (KIRT18) mIRNA 2428 7527 12733 1,0 0 AW466922.1 EST HUMAN ha041104.xl NCI CGAP K1d12 Homo s!plens cDNA done IMAGE:2872759 3' 2430 7529 12734 1.3 0 AW501010.1 EST-HUMAN Ul-HF-BPOp-als-c-07-0-Ul.rl NIH_WC---51 Homo sapiens cIDNA done IMAGE:3072780 5, 2444 7543 12751 0.8 0 5453965 NT Homo sapiens protein kinase, AMP- activated, alpha 2 catalytic subunit (PIRKAA2) mRNA 2444 7543 12752 0.8 0 5453965 NT Horno sapiens protein kinase, AMP- activated, alpha 2 catalytic subunit (PIRKAA2) mIRNA 2457 7556 0,9 0 AW813853.1 EST-HUMAN RC3-ST0197-300300-016-rM ST0197 Homo sapiens cIDNA 2462 7561 12765 5.8 0 4506744 NT Homo sapiens dbosomal protein S9 (RP -9) mIRNA 2463 7014 12203 1.2 0 7657038 NT Homo saplens death receptor 6 (DR6), mRNA 2467 7565 12768 0,8 0 Z32684.2 NT Homo sapiens mIRNA for membrane transport protein (XK gene) 2469 7567 2.0 0 5453871 NT Homo sapiens platelet-derived growth factor reoeptor-like (PIDGFIRL) mIRNA 2471 7569 12771, 0.7 0 AF058953.1 NT Homo saplens ATP-spedfic succinyi- CoA synthetase beta subunit (SCS) mRNA, partial eds 2472 7570 12 0.7 0 7657468 NT Homo sapiens similar to rat integral rinembrane glycoprotein POM121 (POM121 L1), mRNA 2473 7571 12773 20,0 0 4507 Horno sapiens fidn (TTN) mRNA 2474 7572 12774 1.1 0 8923340 NT Homo saplens hypothetical protein FLJ20366 (RJ20366), mIRNA 2475 7573 12775 __1.2 0 4507524 NT Horno saplens translocadon protein 1 (TLOCI) mRNA Page 179 of 196 Table 4

2481 7579 12781 0.6 0 8051635 NT Horno sapiens exportin, tRNA (nuclear export receptor for tRNAs) (XPOT), mRNA 2486 7583 12787 1.6 0 A1804747.1 EST HUMAN tu42cl 1.xl NCLWAP-Pr28 Homo saplens cDNA done IMAGE:2253716Ysimilar to contains element MSR1 repetitive element; 2486 7583 12788 1.6 0 A1804747.1 EST HUMAN tu42cl 1.xl NCI - CGAP - Pr28 Homo sapiens cIDNA done IMAGE:2253716 3'similar to contains element MSR1 repetitive element; 2488 7585 12791 1.0 0 AW888221.1 EST HUMAN WRAS Human matrix tissue expression library Homo sapiens cDNA clone Incyte 1996726 similar to WRA5 Matrix remodeling associated gene 5 2509 7605 12806 1.4 0 4557336 NT Horno sapiens argininosuccinate synthetase (ASS), mRNA 2509 7605 12807 1.4 0 4557336 NT Homo sapiens argininosuccinate synthetase (ASS), mRNA 2510 7606 12808 1.2 0 4506402 NT Horno saplens refinolc acid induced 3 (RA13) mRNA 2510 7606 12809 1.2 0 4506402 NT Homo sapiens refinolc acid Induced 3 (RA13) mRNA 2511 7607 12810 1.0 0 AW589700.1 EST HUMAN hg19e07.xl NCI CGAP - GC6 Homo sapiens cDNA done IMAGE.2946084 Ysimilar to TR:000246 00C246 HIPOTHETICAL 9,3 KI) PROTEIN; 2514 7610 12812 2.8 0 AW937782.1 EST-HUMAN QV3-DT0045-140200-082-el 1 DT0045 Horno sapiens cIDNA 2540 7636 12836 1.1 0 BE296613.1 EST HUMAN 601173631 F1 NIH MGC 17 Homo sapiens cDNA clone IMAGE:3529159 5, 2553 7876 12850 0.9 0 AB037836.1 NT Horno saplens mRNA for KIAA1415 protein, partial ods 2553 7876 12851 0,9 0 AB037836.1 NT Homo sapiens mRNA for KIAA1415 protein, partial cds 2554 7W 1.4 0 BE084725.1 EST HUMAN MR0-13T0659-280200-003-c06 BT0659 Homo sapiens cDNA 2560 7654 12857 1.0 0 8923955 NT Horno sapiens PC326 protein (PC326), mRNA 2562 7656 1.2 0 45M66 NT Horno sapiens ring finger protein (C31-IC4 type) 8 (RNF8), mRNA 2569 7662 12864 1.3 0 A13037742.1 NT Homo sapiensrnRNA for K1AA1 321 protein, partial cds 2570 7663 12865 1.0 0 A1571737.1 EST HUMAN tnlgbO8.xl NCI-CGAP_Bm25 Horno, saplens cIDNA done IMAGE:2168055 Ysimilar to gb:L20977 CALCIUM-TRANSPORTING ATPASE PLASMA MEMBRANE, BRAIN ISOFORM 2 (HUMAN); 2571 7664 12866 0.8 0 5032150 NT Homo sapiens TATA box binding protein (TBPassociated factor, RNA polymerase 11, 1, 28k1D (TAF21) mRNA 2573 7666 12868 2.1 0 AB037859.1 NT Homo sapiens mRNA for KIAA1438 protein, partial cds 2574 7667 12869 1.0 0 AF129756.1 NT Homo sapiens MSH55 gene, partial cds; and CLIC1, DDAH, G6b, G6c, G5b, G6d, G6e, G6f, BAT5, G5b, CSK2B, BAT4, G4, Apo M, BAT3, BAT2, AIF-1, 1C7, LST-1, LTB, TW, and LTA genes, complete cds 2574 7667 12870 1.0 0 AF129756.1 NT Homo sapiens MSH55 gene, partial cds; and CLIC1, DDAH, G6b, G6c. G5b, G6d, G6e, G6f, BAT5, G5b, CSK2B, BAT4, G4, Apo M, BAT3, BAT2, AIF-1, 1C7, LST-1, LTB, TW, and LTA genes. complete cds 2577 7670 12871 1.1 0 BE293328.1 EST-HUMAN 601143722F1 NIH MGC 15 Horno sapiens cDNA done IMAGE:3051389 5' 2585 7678 3.8 0 L19185.1 NT Human natural killer cell enhancing factor (NKEFS) mRNA, complete cds 2595 7687 12890 0.9 0 4504686 NT Homo sapiens IMP (inosine monophosphate) dehydrogenase 1 (IMPDH1) mRNA 2601 7949 12897 2.5 0 4507720 NT Horno saplens fifin CTN) mRNA 2608 7698 1.1 0 U78027.1 NT Horno, saplens Bruton's tyrosine kinase (BTK), alpha-D-galactosidase A (GLA), L44-like dbosomal protein (L441---)and FTP3 (FTP3) genes, complete cds 2609 7699 12901 1.9 0 AF173227.1 NT Homo sapiens guanylate cyclaseactivating protein 2 (GLICA1 B) gene, exon 1 3 7703 12902 1,2 0 AB01 1108.1 NT o sapiens mRNA for KIAA0536 protein, partial cds Page 180 of 196 Table 4

2616 7706 12905 1.0 0 A13002299.1 NT Human mRNA for KIAA0301 gene, partial cds 2617 7707 12906 0.5 0 4502442 NT Homo sapiens bullous pemphigoid andgen 1 (2301240kID) (13PAG1) mRNA 2619 7709 12908 1.2 0 U22377.1 NT Human Zn-1 5 related dric finger protein (rlo mRNA, comelete cds 2619 7709 12909 1.2 0 U22377.1 NT Human Zn-15 related zinc finger protein (d mRNA, complete cds 2622 7712 12912 1.3 0 AW887015.1 EST HUMAN RC1 -OT0086-220300-01 1-d07 OT0086 Homo saplens cDNA 2626 7716 12917 1.0 0 AA994842.1 EST HUMAN ou58e08.sli NCI_OGAP R Homp sapiens cDNA done IMAGE: 1632038 3' 2627 7717 12918 1.2 0 AF265208.1 NT Homo sapiens SW1-SW complex protein p270 mRNA, partial cds 2628 7718 1.0 0 7662223 NT Homo saplens KIAA0649 gene product (K1AA0649), mRNA 2656 7745 12945 0.6 0 8922843 NT Homo saplens hypothetical protein FILA 1052 (FU1 1052), mRNA 2690 7777 3.2 0 AA316723.1 EST HUMAN EST188414 HCC cell line (matastasis to liver in mouse) 11 Homo sapiens cDNA 5' end similar to ribosomal protein L29 2691 7778 12975 0,9 0 J03537.11 NT Human ribosomal protein S6 mRNA, complete cds 2698 7784 12984 1.3 0 U36253.1 NT Human beta-prirne-adaptin (SAM22) gene, exon 5 2700 7166 12986 1.1 0 7669517 NT Homo saplens neuregulin 1 (NRGI), transcdpt variant SIVII3F, mRNA 2701 7787 12987 3.7 0 AF1 10763.1 NT Homo sapiens skeletal muscle LIM- protein 1 (FHLI) gene, complete cds 2708 7793 12994 10.4 0 Y00052.1 NT Human mRNA for T-cell cydoehilin 2709 7794 12995 3.2 0 T07303.1 EST HUMAN EST05192 Fetal brain, Stratagene (cat#936206) Horno sapiens cIDNA done HFBEG84 similar to Ring canal protein 2712 7953 12999 13.5 0 4506696 NT - Homo sapiens dbosomal protein S20 (RPS20) mRNA 2713 7797 1.3 0 A1065139.1 EST-HUMAN HA0977 Human fetal liver cIDNA library Horno sapiens cDNA 2715 7799 13002 0.8 0 5174486 NT Homo sapiens spermatogenesis associated PID1 (K1AA0757) mRNA 2715 7799 13003 0.8 0 5174486 NT Homo saplens spermatogenesis associated PD1 (K1AA0757) mRNA 2716 7800 13004 0.9 0 8923441 NT Homo sapiens hypothetical protein FLJ20477 (FLJ20477), mRNA 2716 7800 13005 0.9 0 8923441 NT Homo sapiens hypothetical protein FLJ20477 (FU20477), mRNA 2717 7801 13006 0.8 0 7661839 NT Homo sapiens HT002 protein (HT002), mRNA 2718 7802 5.7 0 M11147.1 NT Human ferritin L chain mRNA, complete cds 2719 7803 13007 0,6 0 U21556.1 NT Human membrane protein-like protein mRNA, partial ods 2719 7803 13008 0.6 0 U21556.1 NT Human membrane protein-like protein mRNA, partial cds 2723 7807 13011 1.2 0 4757963 NT Horno sapiens cerebellar degeneration- related protein (3413) (CDR1) mRNA 2723 7807 13012 1.2 0 4757963 NT Homo saplens cerebellar degeneradon- related protein (3413) (CDR1) mRNA 2727 7811 13017 0.8 0 4504918 NT Horno saplens keratin 8 (KRT8) mIRNA 2730 7814 13020 1.0 0 BE176836.1 ES-T_HUMAN RC4-HT0587-170300-012-dl 1 HTOW7 Horno sapiens cIDNA 2741 785 1.3 0 AL163201.2 NT Horno sapiens chromosome 21 segment HS21C001 2742 7826 13030 1.3 0 D63879.1 NT Human mIRNA for KIAA0156 gene, comRiete ods 2748 7832 1.1 0 4503098 NT Homo saplens chondroidn sulfate proteoglycan 4 (melanoma-associated) (CSPG4), mRNA 2758 7842 13045 0.6 0 7427522 NT Horno sapiens protein tyrosine phosphatase, receptor type, T (PTPRT), mRNA 2761 7845 13047 3.5 0 AA490647.1 EST_HUMAN aaOlgO4.rl Soares NhHIVIPu_S1 Homo sapiens cIDNA done IMAGE:812022 5'similar to SW21\122LHUMAjP17026 ZINC FINGER PROTEIN 22;contains element LTR6 repetitive element; Page 181 of 196 Table 4

2761 7845 13048 3,5 0 AA490647.1 EST HUMAN aa01g04xl Soares_Nhi-IMPu - S1 Homo sapiens cDNA done IMAGE:812022 5'similar to SW21N122 HUMAN P17026 ZINC FINGER PROTEIN 22;contains element LTR6 repetitive element; 2763 7847 4.0 0 6912633 NT Homo saplens ribosomal protein L1 3a (RPL1 3A), mRNA 2766 7850 13053 0.7 0 AF036943.1 NT Homo sapiens myelin transcription factor 1-like (MYT1-1) mRNA, complete ods 2767 7851 13054 1.1 0 4504918 NT Horno sapien kerafin 8 (KIRT8) mIRNA.

2769 7853 13055 1.1 0 AW505486.1 EST HUMAN Ul-HF-BNO-amb-d-02-0-Ul.rl NIHMGC._50 Homo sapiens cDNA done IMAGE:3081626 5, 2769 7853 13056 1.1 0 AW505486.1 EST-HUMAN U]-HF-BNO-amb-d-02-0-Ul.rl N11- 1-1VIGQ_50 Homo sapiens cIDNA clone IMAGE:3081626 5, 2770 7854 13057 3.7 0 4506648 NT Homo, saplens ribosomal protein L3 (RPL3) mRNA 2770 7854 13056 3.7 0 4506648 NT Homo, sapiens ribosomal protein L3 (RPL3) mRNA 2775 5373 10498 1.6 0 S76830.11 NT glycoprotein D=Duffy group antigen [human, blood, Genomic DNA, 3068 nt) 2778 7860 0.7 0 A130332811.1 NT Homo sapiens BTRCP2 mRNA for F-box and WD- repeats protein isoform C, complete cds 2784 5871 11011 1.4 0 AF264750.1 NT Homo sapiens ALR-like protein mRNA, partial cds 2784 5871 11012 1.4 0 AF264750.11 NT Homo sapiens ALR-like protein mRNA, pardal cds 2789 6163 11316 1.2 0 4503202 NT Homo, sapiens cytochrome P450, subfamily 1 (dio)Cin-inducible), polypeptide 1 (glaucoma 3, primary Infantile) (CYPI131) mRNA 2789 6163 11317 1.2 0 4503202 NT Homo sapiens cytochrome P450, subfamily 1 (dioxin-inducible), polypeptide 1 (glaucoma 3, primary Infantile) (CYP1Bl) mIRNA 2805 7957 13066 2.4 0 X85980.1 NT H.sapiens sedne, hydroxymethyltransferase pseudogene 2806 7958 1.3 0 AF068624.11 NT Homo sapiens 5-aminolevulinate synthase 2 (ALAS2) gene. complete cds 2808 7960 1.1 0 A13040960.11 NT Homo sapiens mRNA for KIAA1527 protein, pardal cds 2814 7965 1.1 0 AJ238852.1 NT Homo sapiens pardal rp13 gene for dbosomal protein L3, U82 snoRNA, U83a snoRNA and U83b snoRNA genes 2815 7966 13070 2.2 0 A1.1163201.2 NT Homo saplens chromosome 21 segment HS21C001 2819 7970 13073 5.9 0 M80902.1 NT Human AHNAK nudeoprotein mRNA, W end 2822 7973 13075 1.6 0 BE154504.1 EST_HUMAN PM0-HT0343-2811299-003-e02 HT0343 Horno sapiens cDNA 2822 7973 13076 1.6 0 BE154504.1 EST HUMAN PIVIO-HT0343-2812WO03-e02 HT0343 Homo sapiens cDNA 2824 7975 1.4 0 X73428.11 NT H.saplens W3 gene for H1-H type transcription factor 2826 7977 2.8 0 AIL163268.2 NT Homo, saplens chromosome 21 segment HS21C068 2828 7979 13079 2.6 0 M98478.11 NT Human transgiutaminase mRNA, complete cds 2833 7984 13083 43.5 0 D50657.11 NT Homo sapiens gammma-cytoplasmic addn (ACTG133) pseudogene 2833 7984 13084 43.5 0 D50657.11 NT Homo sapiens gammma-c)doplasmic actin (ACTGP3) pseudogene 2837 7988 13087 1.3 0 A1.096857.1 NT Novel human mRNA from chromosome 1, which has similarities to BAT2 genes 2838 7989 4.6 0 Y10658.11 NT H.sapiens mRNA for nuclear DNA helicase 11 2839 7990 1.0 0 AF152303.1 NT Homo sapiens protocadhedn alpha Cl (PCDH- alpha-Cl) mRNA, complete cds 2840 7991 13088 25.1 0 4503470 NT Homo sapiens eukaryodc translation elongation factor 1 alpha 1 (EEF1A1) mRNA 2840 7991 13089 25.1 0 4503470 NT Homo sapiens eukaryofic translation elongation factor 1 alpha 1 (EEF1A11) mRNA 2851 8002 13100 2.4 0 4507280 NT Horno sapiens sednelthreonine kinase 9 (ST1K9) mRNA Page 182 of 196 Table 4

2854 8005 13104 1.4 0 AL047599.1 EST HUMAN DKFZp586G06211j1 586 (synonym: hutel) Homo sapiens cDNA clone UFZp586G0621 2855 8006 13105 1.3 0 7661883 NT Homo saplens WAA0054 gene product; Helicase (K1AA0054), mRNA 2665 8006 13106 1.3 0 7661883 NT Homo sapiens KIAA0054 gene product. Helicase (K1AA0054), mRNA 2856 8007 3.4 0 4503098 NT Homo saplens chondroldn sulfate proteoglycan 4 (metanoma-associated) (CSPG4), mRNA 2858 8009 13108 5.0 0 BE081896.1 EST HUMAN QV2-ST0636-130400-138-h03 BT0636 Homo saplens cDNA 2858 8009 13109 5.0 0 BE081896.1 EST HUMAN QV2-BT0636-130400-138-h03 BT0636 Homo saplens cDNA 2866 8017 13120 1.6 0 AL163206.2 NT Homo sapiens chromosome 21 segment HS21 C006 2866 8017 13121 1.6 0 AL1 63206.2 NT Homo saplens chromosome 21 segment HS21 C006 2867 8018 13122 1.1 0 AA215579.1 EST HUMAN zrg6b11.sl NCI_PGAP GCBI Homo sapiens cDNA clone IMAGE:683517 Ysimilar to contains Alu repetitive element:

2874 8025 3.1 0 Y1 9210.1 NT Homo sapiens hHb5 gene for hair keratin, exons 1 to 9 2877 8028 13131 1.2 0 4758279 NT Homo sapiens EphA4 (EPHA4) mRNA 2878 8029 13132 18.7 0 4503470 NT Homo sapiens eukaryodc translation elongation factor 1 alpha 1 (EEFIA1) mRNA 2879 8030 13133 1.3 0 A1561002.1 EST-HUMAN tnl8d07.xl INICI_WAP---13m25 Homo, sapiens cDNA clone IMAGE:2167981 Ysimilar to TR:01 6247 016247 F44E7.2 PROTEIN.; 2879 8030 13134 1.3 0 A1561002.1 EST HUMAN W8d07.xl NCI_QGAP_Bm25 Homo saplens cIDNA clone IMAGE:2167981 Ysimilar to TR:01 6247 016247. F44E7.2 PROTEIN.; 2881 8032 13136 1.9 0 P52740 SWISSPROT ZINC FINGER PROTEIN 132 2882 8033 13137 1.5 0 AF1152338.1 NT Homo saplens protocadherin gamma C4 (PCDH-gamma-C4) mRNA, complete cds 2897 8048 13149 1.3 0 A13033093.1 NT Homo sapiens mIRNA for KIAA1267 protein, partial cds 2897 8048 13150 1.3 0 A13033093.1 NT Homo saplens mRNA for KIAA1267 protein, pardal cds 2898 8049 13151 5.0 0 A13040941.1 NT Homo sapiens mRNA for K1AA1 508 protein, partial ods 2898 8049 13152 5.0 0 A13040941.1 NT Homo saplens mRNA for KtAA1508 protein, partial ods 2901 8052 13155 2.7 0 7661903 NT Homo sapiens KIAA0100 gene product (K1AA0100), mRNA 2901 8052 13156 2.7 0 7661903 NT Homo sapiens KIAA0100 gene product (K1AA0100), mRNA 2902 8053 13157 3.2 0 5174574 NT Homo saplens myeloldnymphold or mixed4Ineage leukemia (trithorax (Drosophila) homolog); translocated to, 4 (MILLT4) mIRNA 2902 8053 13158 3.2 0 5174574 NT omo sapiens myeloidAymphold or mixed- lineage leukemia (trithorax (Drosophila) homolog); translocated to, 4 (MI-LT4) mRNA 2915 8066 13174 2,0 0 4505084 NT Homo sapiens melanoma andgen, family B, 4 (MAGEB4), mRNA 2915 8066 13175 2.0 0 4505084 NT Homo sapiens melanoma antigen. family B, 4 (MAGEB4), mRNA 2917 8068 13177 0.9_ 0 4885214 NT Homo sapiens v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4 (ER13134) mRNA 2917 8068 13178 0.9 0 4885214 NT Homo sapiens v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4 (ERBB4) mRNA 2924 8075 13183 1.6 0 4758827 NT Homo sapiens neurexin Ill (NRXN3) mIRNA 2927 8078 13186 1.3 0 X15309.11 NT H.sapiens NF-H gene, exon 4 2927 8078 13187 1.3 0 X15309.11 NT H.sapjens NF-H gene, exon 4 2929 8080 13189 7.9 0 AF106275.1 NT Homo sapiens lmmunoglobulin-like transcript 1 c variant 4 (ILT1 c) gene, exon 6 V Page 183 of 196 Table 4

Page 184 of 196 2943 8094 1.1 0 A1149880.1 EST HUMAN qf43f09.xl Soares testis NHT Homo sapiens cDNA done IMAGE:1752809 3' 2953 8104 13211 1.0 0 4506118 NT Homo sapiens prospero-related homeobox 1 (PROX1) mRNA 2954 8105 13212 2.2 0 A13004884.1 NT Homo saplens mIRNA for PIKU-alpha, partial cds 2964 8115 13221 1.3 0 7662273 NT Homo sapiens KIAA0737 gene product (K1AA0737), mRNA 2965 8116 13222 1.6 0 5729755 NT Homo sapiens calcium channel, voltage- dependent, gamma subunit 3 (CACNG3), mRNA 2965 8116 13223 1.6 0 5729755 NT Homo sapiens calcium channel, voltage- dependent, gamma subunit 3 (CACNG3), mRNA 2990 8142 0.9 0 A1.163246.2 NT Homo sapiens chromosome 21 segment HS21 C046 2992 8144 13246 1.0 0 M74099.1 NT Human displacement protein (CCAAT) mRNA 3001 8153 13253 6_.8 0 4506882 NT Homo saplens semenogelin 1 (SEIVIG1) mRNA 3009 8161 13262 7.9 0 5579469 NT Homo saplens heat shock 70k1D protein 1 (HSPA1A), mRNA 3009 8161 13263 7.9 0 5579469 NT Homo sapiens heat shock 70ki) protein 1 (HSPAIA), mRNA 3011 8163 5.1 0 AL359403.1 NT lsoform 2 of a novel human mRNA from chromosome 22 3014 8166 13267 2.0 0 AF017433.1 NT Homo sapiens putative transcription factor CR53 (CR53) mRNA, partial cds 3017 8169 1.7 0 AF196779.1 NT Homo saplens transcription factor IGHM enhancer 3, JM1 1 protein, JM4 protein, JIVIS protein, T54 protein, JM10 protein, A4 differentlation-dependent protein, triple LIM domain protein 6, and synaptophysin genes, complete cds; and L-type calcium channel a> 3019 8171 13271 1.0 0 4504664 NT Homo sapiens Interleukin 2 receptor. beta (IL2RB) mRNA 3038 8190 13292 2,8 0 X03529.11 NT Human germline gene 16.1 for]g lambda L-chain C region (19L-C16.1) 3043 8194 1.9 0 AF199355.11 NT Horno saplens F-box protein F131-5 (FBL5) mRNA, complete cds 3047 8198 13299 1.9 0 AF064589.11 NT Homo sapiens melanoma-assoclated antigen (MAGE-Cl) gene, complete cds 3068 8219 13318 2.9 0 AF265208.1 NT Homo sapiens SW1-SNIF complex protein p270 mRNA, partial cds 3069 8220 13319 4.0 0 AF149773.1 NT Homo saplens NOD1 protein (NOD1) gene, exons 1, 2, and 3 3074 8225 13323 4.2 0 7662139 NT Horno sapiens KIAA0469 gene product (K1AA0469), mRNA 3075 8226 13324 1.6 0 AF042075.1 NT Homo sapiens olfactory receptor-like protein (OLFR 4213) gene, OLFR 4213-9110 allele, partial cds 3102 8252 13356 3.5 0 4826783 NT Homo sapiens potassium voltage-gated channel, Shab-related subfamily, member 1 (KCN131) mRNA 3111 8260 13364 19.6 0 L20941.1 NT Human fenitin heavy chain mRNA, complete cds 3115 8264 13368 1.8 0 AB011121.1 NT Homo saplens mRNA for KIAA0549 protein, partial cds 3115 8264 13369 1.8 0 AB01 1121.1 NT Homo sapiens mRNA for KIAA0549 protein. partial cds 3123 8272 13377 9.4 0 T94870.1 EST-HUMAN ye32f01s11 Stratagene lung (#937210) Homo saplens cDNA clone IMAGE:1 19453 Ysimilar to SRS29539 S29539 BASIC PROTEIN, 23K -; 3140 8289 13395 1.0 0 A1968086.1 EST HUMAN wul2h10.xl NCI CGAP GC6 Homo sapiens cDNA clone IMAGE:2516803 X 3145 8294 13402 4.0 0 X98922.1 NT H.saplens mIRNA for gamma- glutamyitransferase 3145 8294 13403 4.0 0 X98922.11 NT H.sapiens mRNA for gamma- glutamyitransferase 3156 8305 13415 1.5 0 4758827 NT Homo saplens neurexin Ill (NIIXN3) mRNA 3156 8305 13416 1.5 0 4758827 NT Homo saplens neurexin Ill (NRXN3) mRNA 8312 134241 7.7 0 4504658 NT Homo sapiens Intedeukin 1 receptor,!Zpe 1 (11-11 RI) mRNA Table 4

3164 8313 13425 3.3 0 4507720 NT Homo sapiens tifin (TTN) mRNA 3164 8313 13426 3.3 0 4507720 NT Homo shple s Udn (TTN) mRNA 3180 8329 13442 2.4 0 M28699.1 NT Homo sapiens nudeolar phosphoprotein B23 (INIPM1) mRNA, complete ods 3183 8332 13444 2.2 0 4502098 NT Homo sapiens solute carder family 25 (mitochondflal carrier; adenine nucleofide 3188 8337 13450 0.8 0 4758055 NT translocator), member 5 (SILC25A5), nuclear gene encoding mitochonddal protein, mRNA 3188 8337 13451 0.8 0 4758055 NT Homo sapiens CREB binding proteinARubinstein-Taybi syndrome) (CREBBP) mRNA Homo sapiens CREB binding protein (Rubinstein-Taybi syndrome) (CREBBIR) mRNA 3190 8339 13452 26.3 0 AA774783.1 EST-HUMAN ae87bl I.sl Stratagene schizo brain S1 1 Homo sapiens cDNA clone IMAGE:971133 3' 3210 8358 13467 1.6 0 4557590 NT Homo sapiens fibrillin 1 (Marfan syndrome) (FBNI) mRNA 3215 8363 13474 3.4 0 4507720 NT Homo sapiens fitin (TTN) mIRNA 3224 8372 13481 4.4 0 M651189.1 NT Human conneWn 43 processed pseudogene 3225 8373 1.2 0 AF019413.1 NT Homo sapiens HLA class Ill region containing tenascin X (tenascin-X) gene, partial cds:

cytochrome P450 21-hydroxylase (CYP21B), complement component C4 (C413) G1 1, helicase (SK12W), RID, complement factor B (B0. and complement component C2 (C2) genes,> 32271 8375 13483 4.2 0 AF055084.1 NT Homo sapiens very large G-protein couple receptor-1 (VILGR1) mRNA, complete cds 3237 10294 13491 3,5 0 4502014 NT Homo sa ns A kinase (PRIKA) anchor protein 1 (AKAP1), mRNA 3237 10294 13492 3.5 0 4502014 NT Homo sapiens A kinase (PRIKA) anchor protein 1 KAP1), mRNA 3252 8399 13505 2.0 0 AF265208.11 NT Homo saplens SWI-SNF complex proteinp270 mRNA, partial cds 3253 8400 13506 0.9 0 8923624 NT Homo sapiens hypothetical protein FLJ20695 (FU20695), mRNA 3282 8427 13535 4.9 0 A1589294.1 EST HUMAN tr58f08.x2 NCLWAP - Peril Horno sapiens cDNA done IMAGE:2222535 Ysimilar to SW:RL1 1-RAT P251 il 60S R1130SOMAL PROTEIN L1 1.;contains Alu repetitive element; 3289 8435 13543 3.0 0 AF128893.1 NT Homo saplens telomerase reverse transcriptase (TERT) gene, exons 1-6 3289 8435 13544 3.0 0 AF128893.1 NT Homo sapiens telomerase reverse transcriptase (TERT) gene, exons 1-6 8436 13545 1.0 0 7657213 NT Homo sapiens hormonally upregulated ne turnor- associated kinase (HUNK), mRNA 3290 8436 13546 1.0 0 7657213 NT Homo saplens hormonally upregulated neu tumor-assodated kinase (HUNK), mRNA 3292 8438 13547 1.0 0 4502582 NT Homo sapiens caspase 8, apoptosis- related cysteine protease (CASP8) mRNA 3292 8438 13548 1.0 0 4502582 NT Homo saplens caspase 8, apoptosis- related cystelne protease (CASP8) mIRNA 3296 8442 13551 11.1 0 AF1 11163.1 NT Homo sapl;ns pyrin (MEFV) gene, complete ods 3298 8444 13553 1.0 0 A13040940.1 NT Homo sapie2s mRNA for K1AA11 507 protei, partial eds 3357 8500 13608 1.7 0 7363436 NT Homo sapi ns olfactory receptor. family 10, subfamily C, member 1 (OR10C1), mRNA 3357 8500 13609 1.7 0 7363436 NT Homo sapiens olfactory ceptor, family 10, subfamily C, member 1 (OR110C1), mRNA 3360 8503 13611 1.4 0 7706239 NT Homo sapiens neuroblastoma-amplified protein (LOC51594), mRNA 3361 8504 13612 1.0 0 AF211189.1 NT Homo saplens T-type calcium channel alphal subunit Alphal 1-a isoform (CACNA1 1) mRNA, S 3377 8520 13626 1.4 0 7662401 NT Homo sapi ns KIAA0952 protein (K1AA0952), mRNA 3377 8520 13627 1.4 0 7662401 NT Homo sapiens KIAA0952 protein (K1AA0952, mRNA 3378 8521 13628 1,0 0 4502398 NT Homo sapiens beaded filament structural protein 1, filensin (B SP1) mRNA Page 185 of 196 Table 4

Page 186 of 196 3381 8524 13630 1.7 0 5803067 NT Homo sapiens leukocyte immunoglobulin- like receptor, subfamily A (with TIV1 domain), member 2 (LILRA2), mRNA 3390 7787 12987 6.0 0 AF110763.1 NT Homo saplens skeletal muscle UM- proteln 1 (FHL1) gene, complete cds 3395 8537 13643 2.1 0 7657038 NT Homo sapiens death receptor 6 (DR6), mRNA 3398 8540 13647 1.5 0 AJ277276.1 NT Homo sapiens mRNA for rapa-2 (rapa gene) 3398 8540 13648 1.5 0 AJ277276.1 NT Homo sap[ ns mRNA for rapa-2 (rapa gene) 3400 8542 13650 5.5 0 K02380.1 NT Bacterlophage P1 replication region including repA, parA, and parS genes and IncA, Inc13, and IncC Incompatibility determinants 3402 8544 13652 1.2 0 7427522 NT Homo sapiens protein tyrosine phosphatase, receptor type, T (PTPRT), mRNA 3409 8551 13658 3.7 0 A1935159.1 EST-HUMAN wpl4d10.xl NCI-CGAP-Lulg Horno sapiens cONA clone IMAGE:2464819 3'Similar to TR:073634 073634 NEURAL CELL ADHESION MOLECULE.:

3409 8551 13659 3.7 0 A1935159.1 EST HUMAN wp14c110xl NCI---CGAP-LU1119 Homo sapiens cIDNA done IMAGE:24W19 3'similar to TR:073634 073634 NEURAL CELL ADHESION MOLECULE.; 3413 8555 13664 2.7 0 AJ278120.1 NT Homo sapiens mIRNA for putative ankyrin-repeat containing protein (ORF1) 3420 8562 13673 2.9 0 6552332 NT Homo sapiens v-fos F13,1 mudne osteosarcoma viral oncogene homolog (FOS), mRNA 3420 8562 13674 2.9 0 6552332 NT Homo sapiens v-fos FBJ mudne osteosarcoma viral oncogene homolog (FOS), mRNA 3426 8568 13680 1.1 0 M14123.1 NT Human endogenous retrovirus HERV-1(10 3431 8573 13685 6.2 0 U43293.11 NT Human MIDSIA (AMLIMS1 fusion) mIRNA, partial cds 3440 8582 13695 2.1 0 AF045452.1 NT Homo saplens cell-line KG1 transcriptional regulatory protein p54 mIRNA, complete eds 3440 8582 13696 2.1 0 AF045452.1 NT Horno sapiens cell-line KZ51 transcriptional regulatory protein p54 mRNA, complete cds 3448 8590 13704 1,2 0 AF231922.1. NT Homo saplens chromosome 21 unknown mRNA 3455 8596 13707 0.9 0 AA626677.1 EST HUMAN ab51f12xl Stratagene lung carcinoma 937218 Homo sapiens c1DNA clone IMAGE:844367 S' 3455 8596 13708 0.9 0 AA626677.1 EST HUMAN ab51f12xl Stratagene lung carcinoma 937218 Homo sapiens cIDNA done IMAGE:844367 S' 3455 8596 13709 0.9 0 AA626677.1 EST HUMAN ab51f12xl Stratagene lung carcinoma 937218 Homo sapiens cIDNA done IMAGE:844367 5' 3458 8599 13712 1.1 0 4508028 NT Homo sapiens zinc finger protein 45 (a Kruppel-assodated box (KRAB) domain polypeptide) (ZNF45) mRNA 3461 8602 13714 2.2 0 BE304791.1 EST-HUMAN 601143853F1 N1H MGC 15 Homo sapiens cIDNA clone IMAGE:3051373 5 3461 8602 13715 2.2 0 BE304791.1 EST HUMAN 601143853F1 NIH_MCJ5 Homo sapiens cIDNA done IMAGE:3051373 5' 3463 8604 13717 1,4 0 4826795 NT Homo sapiens potassium voltage-gated channel, lsk-related family, member 2 (KCNE2) mRNA 3470 8611 13723 0.9 0 A1384007.1 EST HUMAN te35912.xl Soares NhHMPt_Sl Homo sapiens cDNA clone IMAGE:2088742 3' similar to TR:000498 0004C8 MYASTHENIA GRAVIS AUTOANTIGEN GRAVIN:

3473 8614 13726 1.0 0 M110976.1 NT Human endogenous retroviral DNA (M), complete retroviral segment 3495 8637 13749 0.8 0 4506884 NT Horno sapiens semenogelin 11 (SEIVIG2) mIRNA 3497 8639 1.3 0 AF078868.1 NT Homo sapiens homologous yeast-44.2 protein mIRNA, complete cds 3505 8647 13757 1.4 0 AL133204.1 NT Novel human gene mapping to chomosome X 3567 8648 13758 1.0 0 AB040909.1 NT Horno saplens mRNA for KIAA1476 protein, partial cds Table 4

3527 8668 1.0 0 A1081907.1 EST HUMAN ox77cl 1.xl Soares_NhHMPu_Sl Homo sapiens cDNA clone iMAGE:1662356 Ysimilar to WP:T19B4.4 CE13742; 3529 8670 13774 1.3 0 6325463 NT Homo saplens butyrophilin, subfamily 3, member A3 (BTN3A3), mRNA 3533 8674 4.5 0 AW852217.1 ES-T_HUMAN QVO-CTO225.230300-169-e01 CTO225 Homo sapiens cl) 3540 8681 1.0 0 AF1 18846.1 NT Horno sapiens gamma-glutamylcystaine synthetase (GLCLC) gene, partial cds 3564 8703 1.1 0 4826967 NT Homo sapiens rednoblastoma-binding protein 2 (RBBP2) mRNA 3566 8705 13801 1.0 0 AW664693.1 EST-HUMAN h184p01.xl Soares_iNFL T GBC S1 Homo saplens cDNA done IMAGE:2979024 3' 3566 8705 13802 1.0 0 AW664693.1 EST - HUMAN h184o01.xl Soares_NF T_GBCSl Horno sapiens cDNA clone IMAGE:2979024 3, 3569 8708 13806 1,1 0 4826763 NT Homo sapiens heparan sulfate (glucosamine) 3-0-sulfbtransferase 1 (HS3ST1) mRNA 3571 8710 13809 1.0 0 7662319 NT Homo sapiens KIAA0806 gene product (K1AA0806), mRNA 3578 8717 13814 0.8 0 4557752 NT Homo sapiens midline 1 (OpitzJBBB syndrome) (MIDI) mRNA 3578 8717 13815 0.8 0 4557752 NT Homo sapiens midline 1 (Oph7JB8B syndrome) (MIDI) mRNA 3596 8735 13829 1,5 0 D87327.1 NT Homo sapiens mRNA for G protein-coupled Inward rectifier potassium channel, complete cds 3600 8739 28.7 0 7669491 NT Homo sapiens glycoraldehyde-3-phosphate dehydrogenase (GAPD), mRNA 3616 8755 13848 4.3 0 A13026542.1 NT Homo sapiens WAVE2 mRNA for WASP- family protein, complete cds 3619 8798 13850 3.3 0 AF124250.1 NT Homo sapiens SH2-containing protein Nsp2 mRNA, complete cds 3619 8758 13851 3.3 0 AF124250.1 NT Homo saplens SH2-contaiffing protein Nsp2 mRNA, complete cds 3623 8762 13855 1.5 0 AA852743.1 EST---.HUMAN NI-ITBCae1590911 Normal Human Trabecular Bone Cells Homo sapiens c[DNA clone NHT13Cae15g09 3623 8762 13856 1.5 0 AA852743.1 EST-HUMAN NI-ITBCae1590911 Normal Human Trabecular Bone Cells Homo sapiens cDNA clone NHTBCae15909 3626 8765 13858 2.2 0 AL163204.2 NT Homo sapiens chromosome 21 segment HS21 C004 3626 8765 13859 2.2 0 AL163204.2 NT Homo saplens chromosome 21 segment HS21C004 3630 8769 13863 1.8 0 5729928 NT Homo sapiens matrix metalloproteinase 24 (membrane-inserted) (MMP24), mRNA 3632 8771 13865 1.3 0 AB018339.1 NT Homo sapiens mRNA for KIAA0796 protein, partial eds 3645 8784 13876 3.5 0 AW298134.1 EST-HUMAN Ul-H-BWO-aj"-12-0-Ul.sl NCI- CGAP_Sub6 Homo sapiens cDNA clone IMAGE:2733022 3, 3645 8784 13877 3.5 0 AW298134.1 EST-HUMAN L11-H-BWO-ajs-e-12-0-ULsI NCI- CGAP_Sub6 Homo sapiens cDNA done IMAGE:2733022 3' 3668 8807 13901 1.0 0 AB004630.1 NT Human gene for Type XIX collagen al chain, exon 6 3669 8808 13902 1.0 0 AA463659.1 EST HUMAN aa06g01xl SoaresLNhi-IMPq_S1 Homo sapiens cDNA clone IMAGE:812496 V similar to SW:KRB4-SHEEP P02445 KERATIN, HIGH-SULFUR MATRIX PROTEIN, 111B4. [11; 3677 8816 13909 3.4 0 7657468 NT Homo sapiens similar to rat Integral membrane glycoprotein POM121 (POM121L1), mRNA 3687 8825 13919 0.9 0 A13037835.1 NT Homo sapiens mRNA for KIAA1414 protein, partial ods 3699 8838 13929 3.9 0 7662183 NT Homo sapiens KIAA0569 gene product (K1AA0569), mRNA 3701 8840 13931 7.9 0 4506718 NT Homo sapiens dbosomal protein S2 (RPS2) mRNA 3705 8843 13933 1.0 0 7657065 NT Homo sapiens v-eta avian erythroblastosis virus E26 oncogene related (ERG), mRNA 3705 8843 13934 1.0 0 7657065 NT Homo sapiens v-ets avian erythroblastosis virus E26 oncogene related (ERG), mRNA 3746 8884 13973 1.1 AF145712.1 NT Homo sapiens soluble neuropilin-1 mRNA, complete cds f f- Page 187 of 196 Table 4

3747 8885 1.0 0 AF195658.1 NT Homo sapiens DNA mismatch repair protein (MLH3) gene, mplete cds 3748 8886 13974 2.3. 0 AF179733.1 NT Pan troglodytes olfactory receptor (PTR208) gene, partial cds 3751 8889 13978 1.7 0 7657468 NT Homo saplens similar to rat integral membrane glycoprotein POM121 (POM121L1), mRNA 3751 8889 13979 1.7 0 7657468 NT Homo sapiens similar to rat integral membrane glycoprotein POM121 (POM1211-1), mRNA 3752 8890 13980 1.5 0 AF020091.1 NT Homo sapiens smooth muscle myosin heavy chain SM1 mRNA, alternatively spliced, partial eds 3758 8896 13987 1.1 0 A1377699.1 EST HUMAN te62f10.xl Scares NFL T GBC S1 Homo sapiens cIDNA done IMAGE:2091307 3' 3759 8897 1.7 0 AF152496.1 NT Homo sapi s protocadherin beta 3 (PCDH- beta3) mRNA, complete cds 3760 8898 13988 4.5 0 4758199 NT Homo sapiens desmoplakin (DPI, DPI1) (DSP) mRNA 3763 8901 13990 11.7 0 S78685.1 NT Homo sapiens ATP-sensifive Inwardly rectifying K-channel subunit (KCNJ6/BIR1) gene, complete cds 3764 8902 13991 2.0 0 7710148 NT Homo sapiens methyl CpG binding protein 2 (MECP2), mRNA 3765 8903 13992 2.4 0 7662183 NT Homo saple s KIAA0569 gene product (K1AA0 69), mRNA 3768 8906 13994 1.3 0 AF069601.2 NT Homo saplens myosin light chain kinase Isoform 2 (MI-CK) mRNA, complete cds 3768 8906 13995 1.3 0 AF069601.2 NT Homo saplens myosin light chain kinase Isoform 2 (MLCK) mIRNA, complete cds 3769 8907 13996 2.0 0 4504534 NT Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1 D (HTR1 D) mRNA 3773 8910 139991.6 0 AL163279.2 NT Homo sapiens chromosome 21 segment HS21 C079 3775 8912 14002 1.1 0 6912735 NT Homo sapiens transient receptor potential channel 5 (TRIDC5), mRNA 3780 8917 14010 5.7 0 4503178 NT Homo sapiens chromosome X open reading frame 5 (WORF5) mRNA 3780 8917 14011 5.7 0 4503178 NT Homo saplens chromosome X open reading frame 5 (WORF5) mRNA 3782 8919 14014 3.9 0 U09412.1 NT Human zinc finger protein ZNF134 mRNA, complete cds 3784 8921 14015 1.6 0 4826783 NT Horno sapiens potassium voltage-gated channel, Shab-related subfamily, member 1 (KCN131) mRNA 3787 8924 14018 1.0 0 AF012615.1 NT Homo saplens familial mental retardation protein 2 (FIVIR2) gene, exon 11 3788 8925 14019 1.9 0 4759171 NT Homo sapiens SC354nteracting protein 1 (SIRRP1 29), mRNA 3790 8927 14021 0.8 0 AF099117.1 NT Homo sapiens amphiphysin gene, partial ods 3799 8936 14030 2.5 0 A1864727.1 EST_HUMAN M01f01.xl NCI - C_Lym12 Homo sapiens cIDNA done IMAGE:2411065 Ysimilar to TR:043340 043340 R2883p---2.;contains element PTR7 repetitive element; 3802 8939 14034 6,1 0 4506742 NT Homo sapiens dbosomal protein S8 (RPS8), mIRNA 3807 8944 14040. 1.4 0 AL040338.1 EST HUMAN DKIFZp434NO413-M 434 (synonym: btes3) Homo sapiens cIDNA clone DKFZp434NO413 5, 3813 8950 14047 1.0 0 6005887 NT Homo sapi ns AP1 gamma subunit binding protein 1 (AP1 G13P1), mRNA 3813 8950 14048 1.0 0 6005887 NT Homo sapie s AP1 gamma subunit binding protein 1 (AP1GBPl), mIRNA 3815 8952 14050 2.5 0 4504138 NT ns glutamate receptor, metabotropic 3 (GRIVI3) mIRNA 3816 8953 1.8 0 4505078 NT Homo sapiens melanoma antigen, family B, 1 (MAGEB1) mRNA 3820 8957 14053 0.9 0 AF149412.1 NT Homo sapiens I-IBM 7 heparin-binding and FGF-binding protein gene, complete cds 1Homo 3830 8967 14066 1.3 0 4506758 NT Homo sapiens ryanodine receptor 3 (RYR3) mIRNA 3833 8970 14069 1.6 0 4585642 NT sapiens zinc finger protein (K1AA0412) mRNA Page 188 of 196 Table 4

3842 8976 1 1.4 0 AW888221.1 EST HUMAN WRA5 Human matrix tissue expression library Homo sapiens ONA done Incyte 1996726 14078, similar to IVIXIRA5 Matrix remodeling associated gene 5 3842 8978 14079 1.4 0 AW888221.1 EST-HUMAN WRA5 Human matrix tissue expression library Horno sapiens ONA clone Incyte 1996726 similar to IVIXIRA5 Matrix remodeling associated gene 5 3848 8984 14084 1.8 0 AF129533.1 NT Homo saplens F-box protein F1J13b (FB1-38) mRNA, partial cds 3853 8989 14089 3.2 0 BE378602.1 EST-HUMAN 601236966F1 NIM_OWGC 44 Homo sapiens cDNA done IMAGE:3608800 & 3854 8990 14090 1.3 0 BE313146.1 EST-HUMAN 601153727F1 NIM_MGQ_19 Homo sapiens cDNA clone IMAGE:3509743 V 3860 8996 14095 1.0 0 AW580740.1 EST-HUMAN PM3-LT0031-100100-003-h09 LT0031 Homo sajblens cDNA 3893 9028 14119 4.6 0 AF116195.1 NT Homo sapiens cancer-teds andgen CT1 0 (CTI 0) gene, complete ods 3893 9028 14120 4.6 0 AF116195.1 NT Homo sapiens cancer-tesds antigen CT10 (CT10) gene, complete cds 3903 9038 3,9 0 M23910.1 NT Human WC class 11 lymphocyte andgen D%4-beta- 2 pseud2gene, exon 2 3905 9040 5.4 0 AL163303.2 NT Homo sapiens chromosome 21 segment HS21 Cl 03 3912 9047 14135 1,5 0 ALI 18494.1 NT Novel human gene mapping to chomosome 20 3916 9050 14137 2.9 0 AL163284.2 NT Homo sapiens chromosome 21 segment HS21C084 3924 9058 14145 1.5 0 AL1 63268.2 NT Homo sapiens chromosome 21 segment HS21 C068 3935 9069 25.8 0 4503470 NT Homo saplens eukaryotic translation elongation factor 1 alpha 1 (EEFIAI) mRNA 3939 9072 14155 1.2 0 7662183 NT Horno, sapiens KIAA0569 gene product (K1AA0569), mRNA 3940 9073 14156 2.1 0 U09366.1 NT Human zinc finger protein ZNF133 3960 9092 14177 6.2 0 A13015610.1 NT Chlorocebus aethiops mRNA for ribosomal protein S4X, complete cds 3968 9100 3.8 0 AJ238617.11. NT Homo sapiens mRNA for UGA suppressor tRNA- assodiated antigenic protein (tRNA48 gene) 3976 9108 14190 3.3 0 AJ277276.1 NT Homo saplens mRNA for rapa-2 (rapa gene) 3976 9108 14191 3.3 0 AJ277276.1 NT Homo sapiens mRNA for rapa-2 (rapa gene) 3981 9113 14195 5.6 0 5032026 NT Homo saplens rednoblastonia-binding protein 4 (RBBP4) mIRNA 3981 9113 14196 5.6 0 5032026 NT Homo sapiens rednoblastoma-binding protein 4 (R138P4) mIRNA 3993 9125 14209 0.8 0 4503914 NT Homo saplens phosphodbosyiglycJnamide formyitransferase, phosphodbosyfgiycinamide synthetase, phosphodbosylaminolmidazote synthetase (GART) mRNA 4000 9131 14214 4,9 0 4885306 NT Horno sapjens G protein-coupled receptor 21 (GPR21), mRNA 4001 9132 14215 1.9 0 A8006625.1 NT Homo sapiens mRNA for KIAA0287 gene, partial ods 4003 9134 14216 1.3 0 4758807 NT Homo saplens ras GTIPase activating protein-like (NGAP) mRNA 4005 9136 14218 1.6 0 AL096857.1 NT Novel human mRNA from chromosome 1, which has similarities to BAT2 genes 4013 9144 14227 2.7_ 0 AF165527.1 NT Homo sapiens DGCR8 (DGCR8) mRNA, complete cds 4017 10299 14229 0.9 0 AF157476.1 NT Homo saplens DNA polymerase zeta catalytic subunit (REV3) mRNA, complete ods 4022 6253 11404 0.8 0 4826947 NT Homo saplens protein kinase, X-linked (PIRKX) mIRNA 4022 6253 11405 0.8 0 4826947 NT Homo saplens protein kinase, X-linked (PRKX) mIRNA 4028 9156 14239 1.0 0 5901905 NT Homo sapiens butyrophilin, subfamily 3, member A2 (BTN3A2), mRNA 4029 9157 14240 1.2 0 4503854 NT Homo. saplens GA-binding protein transcription factor, alpha subunit (600) (GABPA), mRNA 9157 14241 1.2 0 4503854 NT Homo sapiens GA-binding protein transcription factor, alpha subunit (6OkD) (GA9PA), mRNA (17 I-- C Page 189 of 196 Table 4

Page 190 of 196 4032 9160 14243 1.1 0 8922391 NT Homo saplens hypothetical protein FLJ10379 (FU10379), mRNA 4032 9160 14244 1.1 0 8922391 NT Homo sapiens hypothetical protein FLJ10379 (FU10379), mRNA 4041 9169 14254 4.6 0 A1982597.1 EST HUMAN wuO4d04.xl NCI CGAP GC6 Homo saplens cDNA done IMAGE:2515975 3' 4041 9169 14255 4,6 0 A1982597.1 EST HUMAN wu04d04.xl NCI CGAP,_GC6 Homo saplens cDNA done IMAGE:2515975 3' 4044 9171 14257 0.9 0 BE184856.1 EST HUMAN MR1-HT0707-100500-001-a02 HT0707 Homo sapiens cDNA 4044 9171 14258 0.9 0 BE184856.1 EST-HUMAN MR1-HT0707-100500-001-a02 HT0707 Homo saplens cDNA 4048 9175 2.0 0 BE274217.1 ESI_HUMAN 601120778F1 N1H MGC 20 Homo saplens cIDNA clone IMAGE:2967690 5' 4055 9182 14265 1.0 0 4507476 NT Homo saplens transgiutaminase 3 (E polypepfide, protein-glutamine-gamma glutarnyttransferase) (TGM3) mRNA 4056 9183 14266 2.0 0 5729725 NT Homo sapiens nuclear receptor coactivator 3 XNCOA3), mRNA 4064 9191 6,2 0 AW675599.1 EST-HUMAN ba51f04.xl N11-1 WC---10 Horno, sapiens cIDNA done IMAGE:2900095 Ysimilar to SW:TH12 OVNQ95108MITOCHONC)RIALTHIOREDOX;N PRECURSOR; 4069 9196 14280 1.5 0 AW408788.1 EST-HUMAN Ul-HF-BMO-adx-c-02-0-Ul.rl NIH- MGC-38 Homo sapiens cDNA done IMAGE:3063147 5' 4071 9198 14283 1.3 0 8922466 NT Homo saplens hypothetical protein FLJ10498 (FU10498), mIRNA 4071 9198 14284 1.3 0 8922466 NT Homo saplens hypothetical protein FU1 0498 (FU1 0498), mRNA 4081 9208 2.0 0 5174632 NT Homo sapiens polyeysfic kidney disease (polycysfin) and REJ (sperm receptor for egg jelly, sea urchin homologlike (PKDREJ) mIRNA 4098 9224 14307 7.8 0 AA401438.1 EST HUMAN zu68h07.sl Soares_testis-NHT Homo saplens cIDNA done IMAGE:743197 3' similar to contains Alu repetitive element;contains element MER35 repetitive element; 4098 9224 14308 7.8 0 AA401438.1 EST-HUMAN zu68h07.si SoareE_tesfis-NHT Horno sapiens cDNA done IMAGE:743197 X similar to contains Alu repetitive element;contalns element MER35 repetitive element; 4113 9239 14323 3.8 0 4507720 NT Homo sapiens fitin (TTN) mRNA 4113 9239 14324 3.8 0 4507720 NT Homo saplens fitin CIN) mRNA 4126 9252 14333 0.9 0 4506882 NT Homo saplens semenogelin 1 (SEIVIG1) mRNA 4130 9256 14335 8.2 0 4758199 NT Homo sapi ns desmoplakin (DPI, DPI1) (DSP) mRNA 4130 9256 14336 8.2 0 4758199 NT Homo sapiens desmoplakin (DIRI, DPI I) (DSP) mIRNA 4137 9263 0.9 0 AL163303.2 NT Homo saplens chromosome 21 segment HS21C103 4163 9289 14369 1.1 0 AJ003145.1 NT Horno sapiens mRNA for olfactory receptor protein, pseudogene 4176 9302 14383 7.8 0 J0261 0.1 NT Human apollpoproteln B-100 mRNA, complete cds 4190 9316 14400 1.0 0 AW936689.1 EST HUMAN PM2-DT0023.080300-004'-a08 DT0023 Homo sapiens cIDNA 4196 9322 14408 0,9 0 4826827 NT Homo saplens myelodysplasla syndrome 1 (MDS1) mRNA 4196 9322 14409 0.9 0 4826827 NT Homo sapiens myelodysplasia syndrome 1 (MDS1) mRNA 4198 9324 14411 5.7 0 AF174590.1 NT Homo saplens F-box protein Fb14 (F1314) mIRNA, partial cds 4206 9331 1.9 0 AI 189844.1 EST HUMAN qd23f06.xl SoareMiacente_8to9weeks - 2NbHP8togW Homo sapiens cDNA clone IMAGE:1724579 3' similar to contains MER2012 MER20 repetitive 61ement; 4210 9334 4.1 0 U14520.1 NT Human C13FA3 (Cbfa3) gene, partial cds 4224 9348 14429 1.0 0 4505646 NT Homo saplens proprotein convertase subfllisinlkexin type 2 (PCS1(2) mRNA 4230 9354 14436 0.9 0 6563384 NT Homo sapiens protein kinase C, nu (PRKCN), mIRNA 0 9354 14437 0.9 0 6563384 NT Homo sapiens protein kinase C, nu (PRKCN), mIRNA d4237 A-Human E4230 9361 14443 1.2 0 U10991.1 NT G2 Rrotein mRNA, partial ods Table 4

4237 9361 14444 1.2 0 U10991.1 NT Human G2 protein mRNA, partial ccis 4245 9370 14449 10.2 0 6912281 NT Homo sapiens COMPLEMENT COMPONENT Clq RECEPTOR (C1QIR), MRNA 4263 9388 1.2 0 AF153047.2 NT Homo sapiens gap Junction protein conneyfl- 36 (CX36) gene, complete cds 4268 9393 14475 1.6 0 U03901.1 NT Human 19 Ught: chain V1.1 region germline (humivlc2c) gene, partial cds 4274 9399 14482 5.2 0 1.14561.1 NT Homo sapiens plasma membrane calcium ATPase lsoform 1 (ATP2B1) gene, alternative splice products, partial ods 4278 9403 14487 2.8 0 Z80780.1 NT H.saLens H281b gene 4278 9403 14488 2.8 0 Z80780.1 NT H.sapiens H2B/h gene 4284 9409 14494 1.6 0 X60483.1 NT H.saplens H4/d gene for H4 histone 4284 9409 14495 1.6 0 X60483.1 NT H.saplens H4/d gene for H4 histone 4289 9413 14501 9.0 0 7662091 NT Homo sapiens KIAA0390 gene product (K1AA0390), mRNA 4289 9413 14502 9.0 0 7662091 NT Homo saplens KIAA0390 gene product (K1AA0390), mRNA 4299 9423 14514 10.8 0 4885126 NT ype homeo box transcription factor 4 (CDX4), mRNA Homo saplens caudal t, 4302 9426 14516 1.0 0 A13037781.1 NT Homo saplens mRNA for KIAA1360 protein, pardai,ods 4333 9456 14544 1.1 -0 7019456 NT Homo sapiens myosin regulatory light chain interacting protein (MIR), mRNA 4346 9469 14557 8.1 0 A.1249765.1 NT Homo sapiens ACTN2 gene for alpha- Actiffin 2, exon 10 4346 9469 14558 8.1 0 AJ249765.1 NT Homo sapiens ACTN2 gene for alpha- Actinin 2, exon 10 4368 9490 1.9 0 AF200629.1 NT Homo sapiens HPS1 gene, intron 5 4401 9522 14612 40.2 0 AW084964.1 EST HUMAN xc68e08.xl ISICI-PGAP-Eso2 Homo saplens cDNA done IMAGE:2589446 Ysimilar to WAHNK-HUMAN 009666 NEUROBLAST DIFFERENTIATION ASSOCIATED PROTEIN AHNAK; 4403 10301 1.9 0 8051619 NT Homo sapiens LIM domain kinase 2 (LIMK2), transcript variant 2a,' mRNA 4405 9525 14615 1.4 0 AF016050.1 NT Homo sapiens vascular endothelial cell growth factor 165 receptorineuropilin (VEGFl 65) mRNA, complete cds 4408 9528 7,5 0 A1.163207.2 NT Horno sapiens chromosome 21 segment HS21C007 4410 9530 14619 1.3 0 AW381570.1 ESI-HUMAN PM1-HT0305-101199-002-d03 HT0305 Homo sapiens cDNA 4416 9536 14626 1.8 0 AJ278120.1 NT Homo sapiens mRNA for putative ankydn- ropeat containing protein (ORF1) 4416 9536 14627 1.8 0 AJ278120.1 NT Homo saplens mRNA for putative ankydn- repeat containing protein (ORF1) 4418 9538 14629 3.9 0 4758467 NT Homo sapiens G protein-coupled receptor 50 (GPRW) mRNA 4419 9539 14630 2.3 0 AF108830.1 NT Homo saplens sedne-threonine protein kinase (MNBH) mRNA, complete cds 4424 9544 14636 1.5 0 Z66526.1 NT H.saplens pancreatic Rolypepfide receptor PP1 gene 4429 9550 14643 1.1 0 S78684.1 NT Homo sapiens ATP-sensifive inwardly rectifying K-channel subunit (KCNJ6/BIR1) gene, exon 4430 9551 14644 2.0 0 AF1 11163.1 NT Horno sapiens pyrin (MEFV) gene, complete ods 4430 9551 14645 2.0 0 AF1 11163.1 NT Homo saplens pyrin (MEFV) gene. complete ods 4439 10302 14655 3.1 0 6005973 NT Homo saplens 7Jnc finger protein 195 (ZNFI 95), mRNA 4444 9564 14660 5.4 0 AF208161.1 NT Homo sapiens syncydn precursor, mRNA, complete cds 4449 9569 14667 1.9 0 AF152337.1 NT Homo saplens protocadhedn gamma C3 (PCD1-1-9amma-C3) mRNA, complete cds 4452 9572 14671 1.4 0 5454175 NT Homo sapiens zinc finger protein 211 (ZW21 1), mRNA 4462 9582 14679 15.2 0 4503470 NT Horno sapiens euka!yofic translation elongation factor 1 alpha 1 (EEF1A1) mRNA Page 191 of 196 Table 4

Page 192 of 196 4473 9593 14688 1.5 0 4503098 NT Homo sapiens chondroldn sulfate proteoglycan 4 (melanoma-associated) (CS1PG4), mRNA 4477 9597 14693 1.6 0 4502556 NT ns calcium/calmodulin-dependent protein kinase IV (CAMM) mRNA 4481 9601 2.8.0 L35485.1 NT Homo saplens Iduronate sulphate sulphatase (MS) gene, mplete cds 4483 9603 14695 9.8 0 7662091 NT Homo saplens KIAA0390 gene product (K1AA0390), mRNA 4483 9603 14696 9.8 0 7662091 NT Homo saple s KIAA0390 gene product (K1AA0390), mRNA 4498 9618 14709 2.0 0 AF143314.1 NT Homo sapiens PTEN (PTEN) gene, exons 3 through 5 4500 9620 14711 8.7 0 AJ245418.1 NT Homo sapiens mRNA for G7c protein (G7c gene located in the class Ill region of the major histocompatibility complex) 4500 9620 14712 8.7 0 AJ245418.1 NT Homo sapiens mIRNA for G7c protein (G7c gene located in the class Ill region of the major histocompatibility complex) 4511 9 F3-0 0.8 0 D87675.1 NT Homo sapiens DNA for amyloid precursor protein, complete cds 4523 9642 1.5 0 AA174072.1 EST HUMAN zpl8g08.sl Stratagene fetal retina 937202 Homo sapiens eDNA clone IMAGE:609854 X 4526 9645 1.6 0 7657410 NT Homo saplens odz (odd OzIten-m, Drosophil) homolog 1 (ODZ1), mRNA 4528 9647 1.2 0 AL163284.2 NT Homo sapiens chromosome 21 segment HS21 C084 4529 9648 14737 1.7 0 AF184110.1 NT Homo sapiens cydophilin-related protein (NKTR) gene, complete cds 4530 9649 14738 4.4 0 AL1 63300.2 NT Homo sapiens chromosome 21 segment HS21 Cl 00 4531 9650 1.9 0 AB037521.1 NT Homo sapiens gene for natriuretic protein, partial eds 4541 9660 14748 1.9 0 4557887 NT Homo sapiens keratin 18 (KIRT18) mRNA 4541 9660 14749 1.9 0 4557887 NT Homo sapiens keratin 18 (KIRT18) mRNA 4542 9661 14750 1.3 0 AF153819.1 NT Homo sapiens Inwardly-rectifying potassium channel K4.1 (KCNJ2) gene, exon 2 and complete ods 4542 9661 14751 1.3 0 AF153819.1 NT Homo saplens Inwardly-rectifying potassium channel Kir2.1 (KCNJ2) gene, exon 2 and complete cds 4554 9239 14323 7.4 0 4507720 NT Homo sapiens tifin MN) mRNA 4554 9239 14324 7.4 0 4507720 NT Homo sapiens fitin (TTN) mRNA 4560 9678 14775 22.0 0 Yl 8890.1 NT Human endogenous retrovirus type K (HERV-K), gag, pol and env genes 4566 9684 14778 2.3 0 BE081527.1 EST-HUMAN QV2-BT0635-160400-142-h05 BT0635 Homo sapiens cIDNA 4574 9691 2.0 0 AF086641.1 NT Homo sapiens truncated tenascin XB (MB) gene, pardal ods and TWA gene recombination breakpoint region 4580 9696 14789 2,7 0 AB037820.1 NT Homo saplens mIRNA for KIAA1399 protein, partial cds 4580 9696 14790 2.7 0 AB037820.1 NT Homo saplens mRNA for KIAA1399 protein, partial ods 4581 9697 14791 2.6 0 M74099.1 NT Human displacement protein (CCAAT) mRNA 4585 9700 14794 1.8 0 6453812 NT Homo sapiens butyrophilin, subfamily 2, member A2 (BTN2A2), mRNA 4585 9700 14795 1.8 0 6453812 NT s butyrophilin, subfamily 2, member A2 (BTN2A2), mRNA 4586 5330 10461 1.0 0 T56945.1 EST-HUMAN ya83g04.r2 Stratagene feta. 1 spleen (#937205) Homo sapiens cIDNA clone IMAGE:68310 5' 4586 5330 10462 1.0 0 T56945.1 EST HUMAN ya839044 Stratagene fetal spleen (#937205) Homo sapiens cDNA clone IMAGE:68310 5' 4587 9701 1.0 0 BE278730.1 EST-HUMAN 60115893F1 N1H-MGQ_21 Homo sapiens cDNA clone IMAGE:3505521 5' Table 4

4593 9707 14799 1.1 0 BE390050.1 EST-HUMAN 601285246F1 NIH MGC 44 Homo sapiens ciDNA done IMAGE:3607067 5' 4614 9728 14822 37.4 0 M80902.11. NT Human AHNAK nucleoproteln mRNA, Wend 4617 9731 14825 3.1 0 M69197.1 NT Human haptoglobin and haptoglobin- related protein (HP and HPR) genes, complete cds 4617 9731 14828 3.1 0 M69197.1 NT Human haptoglobin and haptoglobin- related protein (HP and HPR) genes, complete cds 4620 9734 14829 1.1 0 AF184110.1 NT Homo sapiens cydophilin-retated protein (NKTR) gene, complete cds 4621 9735 14830 1.3 0 7662181 NT Homo sapiens KIAA0563 gene product (K1AA0563), mRNA 4636 9750 1.5 0 X58467.1 NT Human CYP2D7AP pseudogene for cytochrome P450 2D6 4644 975-8 14851 1.0 0 7304922 NT Homo sapiens bromodomain adjacent to Mc finger domain, 2B (BAZ2B), mRNA 4644 9758 14852 1.0 0 7304922 NT Homo sapiens bromodomain adjacent to Mc finger domain, 2B (BAZ213), mRNA 4652 9764 14859 1.1 0 AF026801.1 NT Homo sapiens alpha-3 type IX collagen (COL9A3) gene, promoter region, and exons 11-2266 4655 9767 14862 0.9 0 7019320 NT Homo saplens protelnx0008 (AD013), mRNA 4655 9767 14863 0.9 0 7019320 NT Homo saplens proteinx0008 (AD013), mRNA 4676 9788 14887 1.8 0 AW444637.1 EST_HUMAN Ul-H-B13-ajw-c-04-0-Ul.sl NCICGAP_Sub5 Homo sapiens cDNA clone IMAGE:2733294 3' 4686 9798 1.8 0 AF083242.1 NT Homo sapiens HSPC024-1so mRNA, complete cds 4697 9809 2.0 0 M65189.1 NT Human connexin 43 processed pseudogene 4737 99Z8 14940 2.8 0 X137205.1 NT M.fasdculads mRNA for metalloprotease- like, disintegrin-like protein. 1Va 4739 9850 14942 1.3 0 AF084479.1 NT Homo sapiens Williams-Bcuren syndrome deletion transcript 9 (WBSCR9) mRNA, complete cds 4740 9851 14943 1.5 0 AF097416.1 NT Mus musculus zinc finger transcription factor Kaiso mRNA, complete cds 4741 9852 149.44 3.5 0 4503766 NT Homo sapiens fragile X mental retardation 2 (FMR2) mRNA 4743 9854 14946 61.8 0 4885048 NT Homo sapiens actin, alpha, cardiac muscle (ACTC), mRNA 4744 9855 14947 1.4 0 P52740 SWISSPROT ZINC FINGER PROTEIN 132 4746 9857 14949 1.0 0 8922180 NT Horno saplens hypothetical protein WZp762Ell 312 (MFZp762E1 312), mRNA 4748 9859 14951 0,8 0 A1-163203.2 NT Homo sapiens chromosome 21 segment HS21 C003 4752 9863 14956 7.8 0 8923080 NT Homo sa lens hypothedl protein FLJ20073 (FU20073), mRNA 4756 9867 14960 1.0 0 7661979 NT Homo sapiens KIAA0187 gene product (K1AA0187), mRNA 4757 9868 14961 1.7 0 M94081.1 NT Human Tcr-C-delta gene, exons 14; Tcr-V- delta gene, exons 1-2; T-cell receptor alpha (Tcr alpha) gene, J1-M segments; and Tcr-C-alpha gene, exons 1-4 4757 9868 14962 1.7 0 M94081.1 NT Human Tcr-C-delta gene, exons 14; Tcr-V- delta gene, exons 1-2; T-coli receptor alpha (Tcr alpha) gene, J1-J61 segments; and Tcr-C-alpha gene, exons 1-4 4759 9870 1496.4 1.7 0 X94628.1 NT H.sapiens MeCP-2 gene 4759 9870 14965 1.7 0 X94628.1 NT H.sapiens MeCP-2 gene 4762 9873 14968 1.1 0 M55582.11 NT Human collagenase pe IV (CLG4) gene, exon 2 4763 9874 14969 3.2 0 AL163280.2 NT Homo saplens chromosome 21 segment HS21C080 4776 9886 14979 1.0 0 5032150 NT Homo saplens TATA box binding protein (TBPassodated factor, RNA polymerase 11, 1, 28k1D (TAF21) mRNA 4786 9897 14990 0.8 0 6806918 NT Homo sapiens low density lipoprotein- related protein 2 (LRP2), mRNA 4788 9899 14992 1.4 0 X92841.1 NT H.sapiens MICA gene 4791 9902 14995 2.0 0 4585642 NT Homo saplens zinc finger protein (K1AA0412) mRNA C( (>C 0 Page 193 of 195 Table 4

J_ Page 194 of 196 4792 9903 14996 1.2 0 AB014533.1 NY Homo sapiens mRNA for KIAA0633 protein, partial cds 4794 9905 14998 2.3 0 6677648 NT Mus musculus zinc finger protein Interacting with K protein 1 (Zikl), mRNA 4795 9906 14999 1.1 0 5174560 NT Homo sapiens moningioma expressed antigen 6 (coiled-coil proline-rich) (MGEA6), mRNA 4797 9908 15001 8.6 0 4758199 NT Homo saplens desmoplakin (DPI, Will) (DSP) mRNA 4799 9910 15003 1.2 0 Y1 6723.1 NT Homo saplens gene encoding filensin, exon 8 4800 99TT1 15004 1.6 0 7705W NT Homo sapiens zinc-finger DNA-binding protein (HUMHOXY1), mRNA 4801 9912 1.3 0 AJ010442.1 NT Homo saleens mRNA for Immunoglobulin kappa light chain, and-RhD, therad 7 4806 9916 15009 24.9 0 AF055066.1 NT Homo saplens WC class 1 region 4808 9918 2.4 0 4505508 NT Homo sapiens oplold receptor, delta 1 (OPRD1) mRNA 4809 9919 15012 2.5 0 AF091711.1 NT Homo saplens splice variant AKAP350 mRNA, partial cds 4812 9239 14323 5.5 0 4507720 NT Homo sapiens litin (TTN) mRNA 4812 9239 14324 5.5 0 4507720 NT Homo sapiens tifin (TTN) mRNA 4814 9923 15016 0.9 0 A.1277892.1 NT Homo saplens partial TTN gene for titin 4824 9932 15022 12.0 0 4507720 NT Homo sapiens titin (TTN) mRNA 4827 9935 15025 1,0 0 D63562.11 NT Homo sapiens COL4A6 gene for a6(1V) collagen, exon 44 and partial ods 4831 9939 15028 1.5 0 4503684 NT Homo sapiens famesyl diphosphate synthase (famesyl pyrophosphate synthetase, dimethylallyWans"nsferase, geranyltranstransferase) (FDPS) mRNA 4837 9545 14637 1.1 0 4506952 NT Horno sapiens slalyltransferase 8 (alpha- N-acetylneuraminate: alpha-2,8-sialytransferase, GD3 synthase) (SIAT8) mRNA 4845 9952 15040 1.3 0 D15050.1 NT Human mRNA for transcirlption factor AREB6, complete cds 4845 9952 15041 1.3 0 D15050.1 NT Human mRNA for transcripfion factor AREB6, complete ods 4854 9961 15047 0.9 0 A13026898.1 NT Homo sapiens DNA, DLECI to ORCTIL4 gene region, section 112 (DLEC1, ORCTO, ORCTI-4 genes, complete cds) 4871 9978 15062 1.3 0 AL163284.2 NT Horno sapiens chromosome 21 segment HS21 C084 4879 9986 15068 1.5 0 AW452728.1 EST HUMAN Ul-H-B13-alv-f-02-0-Ul.sl NCLWAP-Sub5 Homo sapiens cDNA clone IMAGE:3068691 3, 4885 9993 15074 1.2 0 8922926 NT Homo saplens hypothetical protein FLJI 1190 (FLJI 1190), mIRNA 4886 9932 15022 8.0 0 4507720 NT Homo saplens tifin (rrN) mIRNA 4888 9995 15676 2.8 0 AF058332.1 NT Homo sapiens fitin (TTN) gene, alternative splice products, partial cds 4888 9995 15077 28 0 AF058332.1 NT Homo sapiens fifin CrTN) gene, alternative splice products, partial ods 4894 10001 15084 3.0 0 4507720 NT Homo saplens tifin (TTN) mIRNA 4897 10004 4.3 0 U14967.1 NT Human ribosornal protein L21 mRNA, complete cds 4910 10017 2.6 0 BE408863.1 EST-HUMAN 601303729F1 NIFI.MGQj211 Homo sapiens cDNA clone IMAGE:3638118 5' 4915 10022 15101 5.4 0 4758199 NT Homo saplens desmoptakin (DPI, DPI1) (DSP) mIRNA 4925 10032 15106 1.0 0 A13028966.1 NT Homo sapiens mIRNA for K1AA1 043 protein, partial cds 4939 10045 15116 1 7W 0 8923441 NT Homo sapiens hypothetical protein FLJ20477 (RJ20477), mRNA 4939 10045 15117 1.7 0 8923441 NT Horno saplens hypothetical protein FLJ20477 (FU20477), mRNA Table 4

Homo sapiens chromosome Xq28 melanoma antigen family A2a (MAGEA2A), melanoma antigen family A12 (MAGEA12), melanoma antigen family A2b (MAGEA2B), melanoma antigen family A3 (MAGEA3), caltractin (CALT), NAD(P)H dehydrogenase-like protein 4953 10058 15128 1.1 0 U82671.2 NT (NSDHL), and Li> Homo saplens chromosome Xq28 melanoma antigen family A2a (MAGEA2A), melanorna antigen family A12 (MAGEA12), melanoma antigen family A2b (MAGEA213), melanoma antigen family A3 (MAGEA3), caltractin (CALT), NAD(P)1-1 dehydrogenase- like protein 4953 10058 151291 1.1 0 U82671.2 NT (NSDHL), and U> 4957 9239 143231 5.8 0 4507720 NT Homo saplens tifin CIN) mRNA 4957 9239 143241 5,8 0 4507720 NT Homo sapiens titin (TTN) mRNA 4959 10062 15134 3,5 0 4507120 NT Homo sapiens Edn (TTA) mRNA 4960 10063 15135 7.8 0 4507720 NT Homo saplens fifin (TTN) mRNA 4968 10071 1.2 0 4758225 NT Homo sapiens E2F transcription factor 2 (E2F2) mRNA 4978 10081 15151 1.4 0 AF016705.1 NT Homo sapiens E6-AP ubiquidn-protein ligase (UBE3A) gene, exon 3 4987 10090 1.3 0 AL163209.2 NT Homo sapiens chromosome 21 segment HS21 C009 4990 10093 37,8 0 D50657.1 NT Homo sapiens gammma-cytoplasmic actin (, kCTGP3) pseudogene 5000 10103 151711 2,3 0 AJ277892.1 NT Homo saplens partial TTN gene for fifin 5001 10104 15172 3.0 0 4507720 NT Homo sapiens dUn (TTN) mRNA 5003 10106 15174 4.2 0 4507720 NT Homo saplens fitin (TTN) mRNA 5005 9239 14323 2.9 0 4507720 NT Homo saplens titin 07N) mRNA 5005 9239 14324 2.9 0 4507720 NT Homo sapiens tifin (TTN) mRNA 5018 10120 15192 2.4 0 X52988.1 NT Bacillus amyloliquefadens sacB gene for levansucrase (EC 2.4.1.10) 5037 10137 152131 1.8 0 AF240635.1 NT Horno saplens vascular endothelial cadherin 2 mRNA, complete cds W37 10137 15214 1.8 0 AF240635.1 NT Homo saplens vascular endothelial cadherin 2 mRNA, complete cds 5040 10140 15218 1.0 0 5454153 NT Homo saplens cyclophilin (USA-CYP) mRNA 5054 10154 15230 1.2 0 6677700 NT Homo sapiens G-protein coupled receptor (RE2), mRNA 5055 9239 14323 11.2 0 4507720 NT Homo saplens fitin (nN) mRNA 5055 -9239 14324 11.2 0 4507720 NT Horno saple s tifin (TTN) mRNA 5056 92319 143231 14.9 0 4507720 NT Homo saplens fifin (TTN) mRNA 5056 9239 14324 14.9 0 4507720 NT Homo sapiens titin (TTN} mRNA 5065 10163 15240 1.3 0 4557362 NT Homo saplens PR domain containing 1, vAth ZNF domain (PR13M1) mRNA 5070 10168 15245 1.0 0 M10905.1 NT Human cellular fibronectin MRNA 5070 10168 15246 1.0 0 M10905.1 NT Human cellular fibronectin mRNA Human hereditary haemochromatosis region, histone 2A-like protein gene, hereditary haemochromatosis (HLA-H) gene, RoRet gene, and sodium phosphate transporter (NPT3) 5071 10169 152471 1.1 0 U91328.1 NT gene, complete cds 5080 10178 152581 3.0 0 4507720 NT Homo sapiens tifin (TTN) mRNA 5096 9232 143231 6,3 0 4507720 NT Homo saplens fitin (TTN) mRNA 5096 9232 143241 6.3 0 4507720 NT Homo saplens tifin (TTN) mRNA 5098 10195 152751 1.3 0 L35475.1 NT Human olfactory receptor-like gene, complete cds 5098 10195 15276 1.3 0 L35475.1 NT Human olfactory receptor-like gene, complete cds Page 195 of 196 Table 4

5099 9239 14323 9.4 0 4507720 NT Homo saplens Udn (TTN) mRNA 5099 9239 14324 9.4 0 4507720 NT Homo sapiens titin (TTN) mRNA 5124 10220 15297 0.9 0 AF1 95658.1 NT Homc saplens DNA mismatch repair protein (MLH3) gene, complete cds 5126 10221 15298 1.4 0 5360213 NT Horno sapiens glypican 3 (GPC3) mRNA 5130 10225 15300 0.8 0 AE000327.11 NT Escherichla coil K-1 2 MG1 655 section 217 of 400 of the complete genome 5140 10235 15310 1.1 0 4885474 NT Homo saplens melanoma andgen, family C, 1 (MAGECI). mRNA 5159 10254 15325 1.0 0 4885474 NT Homo saplens melanoma antigen, family C, 1 (MAGEC1), mRNA 5162 10256 15326 1.6 0 4758697 NT Homo saplens mannosidase, alpha, class 2A, member 1 (MAN2A1), mRNA 5165 10259 15329 1.1 0 AF245703.1 NT Homo saplens toll41ke receptor 8 (TLR8) mRNA, complete cds 5165 10259 15330 1.1 0 AF245703.1 NT Homo saplens toll-like receptor 8 (TLR8) mRNA, complete cds 5186 10278 15346 1.7 0 AF006061.1 NT Homo saplens placental growth hormone Isoform hGH-W (hGH-V) mRNA, complete cds 5187 9239 14323 10.4 0 4507720 NT Homo sapiens titin (TTN) mRNA 5187 9239 14324 10.4 0 4507720 NT Homo, saplens fifin (TTN) mRNA 5189 10280 15348 6.8 0 4507720 NT Homo saplens titin (TTN) mRNA 5193 10284 1.4 0 AL1 63285,2 NT Horno, saplens chromosome 21 segment HS21 C085 5195 10286 15354 4.0 0 4507720 NT Horno saplens fitin (TTN) mRNA 5195 10286 15355 4.0 0 4507720 NT Horno saplens fifin (TTN) mRNA 10287 15356 1.0 0 4502398 NT Homo saplens beaded filament structural protein 1, filensin (BFSP1) mRNA Page 196 of 196 2-8-7-

Claims (15)

1. A spat ially- addressable set of single exon nucleic acid probes for measuring gene expression in a sample derived from human heart comprising a plurality single exon nucleic probes, said probes comprising any one of the nucleotide sequences set out in SEQ ID NOs: 1 - 5,202 or a complementary sequence, or a portion of such a sequence.

2. A spatially addressable set of single exon nucleic acid probes as claimed in claim 1 wherein each of said plurality of probes is separately and addressably amplifiable.

3. A spatially- addressable set of single exon nucleic acid probes as claimed in claim 1 wherein each of said plurality of probes is separately and addressably isolatable from said plurality.

4. A spat i al ly- addres sable set of single exon nucleic acid probes as claimed in any of claims 1 to 3 wherein said probes comprise any one of the nucleotide sequences set out in SEQ ID NOS.: 5,203 - 10, 283.

5. A spatially- addressable set of single exon nucleic acid probes as claimed in any of claims 1 to 4, wherein each of said plurality of probes is amplifiable using at least one common primer.

6. A spatial ly- addres sable set of single exon nucleic acid probes as claimed in any of claims 1 to 5 wherein the set comprises between 50 20,000 single exon nucleic acid probes.

7. A spatially-addressable set of single exon nucleic acid probes as claimed in any of claims 1 to 6, wherein the 2-C % average length of the single exon nucleic acid probes is between 200 and 500 bp.

8. A spatial ly- addressable set of single exon nucleic acid probes as claimed in any of claims 1 to 7, wherein at least 50% of said single exon nucleic acid probes lack prokaryotic and bacteriophage vector sequence.

9. A spatial ly- addressable set of single exon nucleic acid probes as claimed in any of claims 1 to 8, wherein at least 50% of said single exon nucleic acid probes lack homopolymeric stretches of A or T.

10. A spatial ly-addressable set of single exon nucleic acid probes as claimed in any of claims 1 - 9 characterised in that said set of probes is addressably disposed upon a substrate.

11. A spatial ly- addressable set of single exon nucleic acid probes as claimed in claim 10 wherein said substrate is selected from glass, amorphous silicon, crystalline silicon and plastic.

12. A microarray comprising a spatially addressable set of single exon nucleic acid probes as claimed in any of claims 1 - 11.

13. A single exon nucleic acid probe for measuring human gene expression in a sample derived from human heart comprising a nucleotide sequence as set out in any of SEQ ID N0s.: 1 - 5, 202 or a complementary sequence or a fragment thereof wherein said probe hybridizes at high stringency to a nucleic acid molecule expressed in the human heart.

14. A single exon nucleic acid probe as claimed in claim 13 comprising a nucleotide sequence as set out in any of SEQ ID N0s.: 5, 203 - 10,283 or a complementary sequence or a fragment thereof. 5 15. A single exon nucleic acid probe for measuring human gene expression in a sample derived from human heart which is a nucleic acid molecule having a sequence encoding a peptide comprising a peptide sequence as set out in any of SEQ ID N0s.: 10, 284 - 15, 322, or a complementary sequence or a fragment thereof wherein said probe hybridizes at high stringency to a nucleic acid expressed in the human heart.

16. A single exon nucleic acid probe as claimed in any one of claims 13 to 15 wherein said single exon nucleic acid probe comprises between 15 and 25 contiguous nucleotides of said SEQ ID NO.

17. A single exon nucleic acid probe as claimed in any one of claims 13 to 15, wherein said probe is between 3 - 25 kb in length.

18. A single exon nucleic acid probe as claimed in any one.of claims 13 17, wherein said probe is DNA, RNA or PNA.

19. A single exon nucleic acid probe as claimed in any one of claims 13 18, wherein said probe is detectably labeled.

20. A single exon nucleic acid probe as claimed in any one of claims 13 19, wherein said probe lacks prokaryotic and bacteriophage vector sequence.

21. A single exon nucleic acid probe as claimed in any one 0 of claims 13 - 20, wherein said probe lacks homopolymeric stretches of A or T.

22. A method of measuring gene expression in a sample derived from human heart, comprising: contacting the microarray of claim 12, with a first collection of detectably labeled nucleic acids, said first collection of nucleic acids derived from mRNA of human heart; and then measuring the label detectably bound to each probe of said microarray.

23. A method of identifying exons in a eukaryotic genome, comprising:

algorithmically predicting at least one exon from genomic sequence of said eukaryote; and then detecting specific hybridization of detectably labeled nucleic acids to a single exon probe, wherein said detectably labeled nucleic acids are derived f rom mRNA f rom the heart of said eukaryote, said probe is a single exon probe having a fragment identical in sequence to, or complementary in sequence to, said predicted exon, said probe is included within a microarray according to claim 12, and said fragment is selectively hybridizable at high stringency.

24. A method of assigning exons to a single gene, comprising:

identifying a plurality of exons from genomic sequence according to the method of claim 23; and then measuring the expression of each of said exons in a plurality of tissues and/or cell types using hybridization to single exon microarrays having a probe with said exon, 7-91 wherein a common pattern of expression of said exons in said plurality of tissues and/or cell types indicates that the exons should be assigned to a single gene.

25. A nucleic acid sequence as set out in any of SEQ ID NOs: 1 - 10,283 which encodes a peptide.

26. A peptide encoded by a sequence as set out in any of SEQ ID Nos: 1 10,283. 10 27. A peptide comprising a sequence as set out in any of SEQ ID Nos: 10,284 - 15,322.

2612- Amendments to the claims have been filed as follows 1. A spatially-addressable set of single exon nucleic acid probes for measuring gene expression in a sample derived from human heart comprising at least 50 single exon nucleic probes, said probes comprising any one of the nucleotide sequences set out in SEQ ID NOs: 1 5,202 or a complementary sequence, or a unique fragment of such a sequence wherein at least 50% of said single exon nucleic acid probes lack prokaryotic and bacteriophage vector sequence and wherein at least 50% of said single exon nucleic acid probes lack homopolymeric stretches of A & T.

2. A spati a lly-addres sable set of single exon nucleic acid probes as claimed in claim 1 wherein each of said plurality of probes is separately and addressably amplifiable.

3. A spatial 1 y-addres sable set of single exon nucleic acid probes as claimed in claim 1 wherein each of said plurality of probes is separately and addressably isolatable from said plurality.

4. A spat i al ly-addres sable set of single exon nucleic acid probes as claimed in any of claims 1 to 3 wherein said probes comprise any one of the nucleotide sequences set out in SEQ ID NOS.: 5,203 - 10,283.

5. A spati ally-addre s sable set of single exon nucleic acid probes as claimed in any of claims 1 to 4, wherein each of said plurality of probes is amplifiable using at least one common primer.

2C1 3 6. A spatially-addre s sable set of single exon nucleic acid probes as claimed in any of claims 1 to 5 wherein the set comprises between 50 20, 000 single exon nucleic acid probes.

7. A spatially- addre s sable set of single exon nucleic acid probes as claimed in any of claims 1 to 6, wherein the average length of the single exon nucleic acid probes is between 25 and 500 bp.

10. A spat i al lyaddre s sable set of single exon nucleic acid probes as claimed in any of claims 1 - 9 characterised in that said set of probes is addressably disposed upon a substrate.

11. A spatial ly-addres sable set of single exon nucleic acid probes as claimed in claim 10 wherein said substrate is selected from glass, amorphous silicon, crystalline silicon and plastic.

12. A microarray comprising a spatially addressable set of single exon nucleic acid probes as claimed in any of claims 1 - 11.

13. A method of measuring gene expression in a sample derived from human heart, comprising: contacting the microarray of claim 12, with a first collection of detectably labeled nucleic acids, said first collection of nucleic acids derived f rom mRNA of human heart; and then measuring the label detectably bound to each probe of said microarray.

09- cl t- 14. A method of identifying exons in a eukaryotic genome, comprising: algorithmically predicting at least one exon from genomic sequence of said eukaryote; and then detecting specific hybridization of detectably labeled nucleic acids to a single exon probe, wherein said detectably labeled nucleic acids are derived from mRNA from the heart of said eukaryote, said probe is a single exon probe having a fragment identical in sequence to, or complementary in sequence to, said predicted exon, said probe is included within a microarray according to claim 12, and said fragment is selectively hybridizable at high stringency.

15. A method of assigning exons, to a single gene, comprising: identifying a plurality of exons from genomic sequence according to the method of claim 14; and then measuring the expression of each of said exons in a plurality of tissues and/or cell types using hybridization to single exon microarrays having a probe with said exon, wherein a common pattern of expression of said exons in said plurality of tissues and/or cell types indicates that the exons should be assigned to a single gene.