GB2360284B - Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart - Google Patents

Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart

Info

Publication number
GB2360284B
GB2360284B GB0024263A GB0024263A GB2360284B GB 2360284 B GB2360284 B GB 2360284B GB 0024263 A GB0024263 A GB 0024263A GB 0024263 A GB0024263 A GB 0024263A GB 2360284 B GB2360284 B GB 2360284B
Authority
GB
United Kingdom
Prior art keywords
analysis
nucleic acid
gene expression
human
acid probes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0024263A
Other versions
GB2360284A (en
GB0024263D0 (en
Inventor
Sharron Gaynor Penn
David R Rank
Wensheng Chen
David Kagen Hanzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ANNOMAX Inc
Integenx Acquisition Corp
Aeomica Inc
Original Assignee
ANNOMAX Inc
Aeomica Inc
Molecular Dynamics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ANNOMAX Inc, Aeomica Inc, Molecular Dynamics Inc filed Critical ANNOMAX Inc
Priority to GB0115281A priority Critical patent/GB2361238B/en
Publication of GB0024263D0 publication Critical patent/GB0024263D0/en
Priority to GB0123361A priority patent/GB2373500B/en
Priority to PCT/US2001/003003 priority patent/WO2001057252A2/en
Priority to AU2001236589A priority patent/AU2001236589A1/en
Priority to US09/774,203 priority patent/US20020081590A1/en
Priority to EP01905211A priority patent/EP1290217A2/en
Priority to AU2001233114A priority patent/AU2001233114A1/en
Priority to AU3087801A priority patent/AU3087801A/en
Priority to PCT/US2001/002967 priority patent/WO2001057251A2/en
Priority to PCT/US2001/000666 priority patent/WO2001057274A2/en
Priority to GB0217049A priority patent/GB2383043B/en
Priority to PCT/US2001/000667 priority patent/WO2001057275A2/en
Priority to AU2001230883A priority patent/AU2001230883A1/en
Priority to PCT/US2001/000668 priority patent/WO2001057276A2/en
Priority to AU2001232759A priority patent/AU2001232759A1/en
Priority to AU2001232757A priority patent/AU2001232757A1/en
Priority to EP01904810A priority patent/EP1309725A2/en
Priority to GB0217714A priority patent/GB2374872A/en
Priority to EP01903006A priority patent/EP1292705A2/en
Priority to GB0218673A priority patent/GB2376237A/en
Priority to AU2001232758A priority patent/AU2001232758A1/en
Priority to EP01904809A priority patent/EP1325150A2/en
Priority to AU2001232760A priority patent/AU2001232760A1/en
Priority to PCT/US2001/000661 priority patent/WO2001057270A2/en
Priority to GB0217811A priority patent/GB2382814B/en
Priority to EP01903007A priority patent/EP1290216A2/en
Priority to GB0406165A priority patent/GB2396351B/en
Priority to EP01903004A priority patent/EP1292704A2/en
Priority to GB0217805A priority patent/GB2378754B/en
Priority to GB0408566A priority patent/GB2397376B/en
Priority to EP01903002A priority patent/EP1309723A2/en
Priority to GB0217112A priority patent/GB2375539B/en
Priority to PCT/US2001/000662 priority patent/WO2001057271A2/en
Priority to AU2001230879A priority patent/AU2001230879A1/en
Priority to GB0216928A priority patent/GB2374929A/en
Priority to PCT/US2001/000665 priority patent/WO2001086003A2/en
Priority to PCT/US2001/000663 priority patent/WO2001057272A2/en
Priority to GB0217835A priority patent/GB2385053B/en
Priority to EP01903003A priority patent/EP1309724A2/en
Priority to AU2001230881A priority patent/AU2001230881A1/en
Priority to EP01904808A priority patent/EP1332224A2/en
Priority to PCT/US2001/000664 priority patent/WO2001057273A2/en
Priority to GB0217188A priority patent/GB2375111B/en
Priority to EP01903005A priority patent/EP1325149A2/en
Priority to AU2001230880A priority patent/AU2001230880A1/en
Priority to GB0406170A priority patent/GB2396352B/en
Priority to EP01904807A priority patent/EP1341930A2/en
Priority to PCT/US2001/000670 priority patent/WO2001057278A2/en
Priority to AU2001230882A priority patent/AU2001230882A1/en
Priority to PCT/US2001/000669 priority patent/WO2001057277A2/en
Priority to GB0217861A priority patent/GB2376018B/en
Priority to AU6343201A priority patent/AU6343201A/en
Priority to US09/864,761 priority patent/US20020048763A1/en
Priority to US09/866,108 priority patent/US6686188B2/en
Priority to PCT/US2001/016981 priority patent/WO2001092524A2/en
Priority to JP2002500716A priority patent/JP2004501617A/en
Priority to GB0227802A priority patent/GB2380197A/en
Priority to US09/895,040 priority patent/US20020123474A1/en
Publication of GB2360284A publication Critical patent/GB2360284A/en
Priority to AU2001292957A priority patent/AU2001292957A1/en
Priority to PCT/US2001/029656 priority patent/WO2002024750A2/en
Application granted granted Critical
Publication of GB2360284B publication Critical patent/GB2360284B/en
Priority to US10/723,361 priority patent/US20040137589A1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/20—Polymerase chain reaction [PCR]; Primer or probe design; Probe optimisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Life Sciences & Earth Sciences (AREA)
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Microbiology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
GB0024263A 2000-02-04 2000-10-04 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart Expired - Fee Related GB2360284B (en)

Priority Applications (61)

Application Number Priority Date Filing Date Title
GB0115281A GB2361238B (en) 2000-02-04 2000-10-04 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart
GB0123361A GB2373500B (en) 2000-02-04 2001-01-29 Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
PCT/US2001/003003 WO2001057252A2 (en) 2000-02-04 2001-01-29 Methods and apparatus for high-throughput detection and characterization of alternatively spliced genes
AU2001236589A AU2001236589A1 (en) 2000-02-04 2001-01-29 Methods and apparatus for high-throughput detection and characterization of alternatively spliced genes
US09/774,203 US20020081590A1 (en) 2000-02-04 2001-01-29 Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
EP01905211A EP1290217A2 (en) 2000-02-04 2001-01-29 Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
AU2001233114A AU2001233114A1 (en) 2000-02-04 2001-01-29 Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
AU3087801A AU3087801A (en) 2000-02-04 2001-01-29 Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human breast and hbl 100 cells
PCT/US2001/002967 WO2001057251A2 (en) 2000-02-04 2001-01-29 Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
PCT/US2001/000666 WO2001057274A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart
GB0217049A GB2383043B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human brain
PCT/US2001/000667 WO2001057275A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human brain
AU2001230883A AU2001230883A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human hela cells or other human cervical epithelial cells
PCT/US2001/000668 WO2001057276A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human bone marrow
AU2001232759A AU2001232759A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human brain
AU2001232757A AU2001232757A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human adult liver
EP01904810A EP1309725A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human fetal liver
GB0217714A GB2374872A (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human bone marrow
EP01903006A EP1292705A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human bone marrow
GB0218673A GB2376237A (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human lung
AU2001232758A AU2001232758A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human lung
EP01904809A EP1325150A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human brain
AU2001232760A AU2001232760A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human fetal liver
PCT/US2001/000661 WO2001057270A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human breast and hbl 100 cells
GB0217811A GB2382814B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human hela cells or other human cervical epithelial cells
EP01903007A EP1290216A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human hela cells or other human cervical epithelial cells
GB0406165A GB2396351B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human lung
EP01903004A EP1292704A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human placenta
GB0217805A GB2378754B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human breast and BT 474 cells
GB0408566A GB2397376B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart
EP01903002A EP1309723A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human breast and hbl 100 cells
GB0217112A GB2375539B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human adult liver
PCT/US2001/000662 WO2001057271A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human breast and bt 474 cells
AU2001230879A AU2001230879A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human breast and bt 474 cells
GB0216928A GB2374929A (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart
PCT/US2001/000665 WO2001086003A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human lung
PCT/US2001/000663 WO2001057272A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human placenta
GB0217835A GB2385053B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human breast and HBL 100 cells
EP01903003A EP1309724A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human breast and bt 474 cells
AU2001230881A AU2001230881A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart
EP01904808A EP1332224A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human lung
PCT/US2001/000664 WO2001057273A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human adult liver
GB0217188A GB2375111B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human fetal liver
EP01903005A EP1325149A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart
AU2001230880A AU2001230880A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human placenta
GB0406170A GB2396352B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human bone marrow
EP01904807A EP1341930A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human adult liver
PCT/US2001/000670 WO2001057278A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human hela cells or other human cervical epithelial cells
AU2001230882A AU2001230882A1 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human bone marrow
PCT/US2001/000669 WO2001057277A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human fetal liver
GB0217861A GB2376018B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human placenta
AU6343201A AU6343201A (en) 2000-05-26 2001-05-23 Myosin-like gene expressed in human heart and muscle
US09/864,761 US20020048763A1 (en) 2000-02-04 2001-05-23 Human genome-derived single exon nucleic acid probes useful for gene expression analysis
US09/866,108 US6686188B2 (en) 2000-05-26 2001-05-25 Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle
PCT/US2001/016981 WO2001092524A2 (en) 2000-05-26 2001-05-25 Myosin-like gene expressed in human heart and muscle
JP2002500716A JP2004501617A (en) 2000-05-26 2001-05-25 Myosin-like gene expressed in human heart muscle and muscle
GB0227802A GB2380197A (en) 2000-05-26 2001-05-25 Myosin-like gene expressed in human heart and muscle
US09/895,040 US20020123474A1 (en) 2000-10-04 2001-06-29 Human GTP-Rho binding protein2
AU2001292957A AU2001292957A1 (en) 2000-09-21 2001-09-21 Human kidney tumor overexpressed membrane protein 1
PCT/US2001/029656 WO2002024750A2 (en) 2000-09-21 2001-09-21 Human kidney tumor overexpressed membrane protein 1
US10/723,361 US20040137589A1 (en) 2000-05-26 2003-11-26 Human myosin-like polypeptide expressed predominantly in heart and muscle

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US20030194704A1 (en) * 2002-04-03 2003-10-16 Penn Sharron Gaynor Human genome-derived single exon nucleic acid probes useful for gene expression analysis two
CN108766527B (en) * 2018-04-20 2021-11-30 拉扎斯网络科技（上海）有限公司 Method and device for determining food calorie
CN112980948B (en) * 2020-08-28 2023-03-21 中山大学附属口腔医院 Application of NFAT3 as therapeutic target in screening or preparing head and neck squamous cell carcinoma drugs
CN112280902B (en) * 2020-11-17 2022-04-01 武汉大学 Method for detecting molluscum virus by TaqMan probe fluorescent quantitative PCR and application

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