GB2360284B - Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart - Google Patents

Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart

Info

Publication number
GB2360284B
GB2360284B GB0024263A GB0024263A GB2360284B GB 2360284 B GB2360284 B GB 2360284B GB 0024263 A GB0024263 A GB 0024263A GB 0024263 A GB0024263 A GB 0024263A GB 2360284 B GB2360284 B GB 2360284B
Authority
GB
United Kingdom
Prior art keywords
analysis
nucleic acid
gene expression
human
acid probes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0024263A
Other versions
GB0024263D0 (en
GB2360284A (en
Inventor
Sharron Gaynor Penn
David R Rank
Wensheng Chen
David Kagen Hanzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Annomax Inc
Integenx Acquisition Corp
Aeomica Inc
Original Assignee
Integenx Acquisition Corp
Aeomica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US18031200P priority Critical
Priority to US20745600P priority
Priority to US23468700P priority
Application filed by Integenx Acquisition Corp, Aeomica Inc filed Critical Integenx Acquisition Corp
Priority claimed from GB0115281A external-priority patent/GB2361238B/en
Publication of GB0024263D0 publication Critical patent/GB0024263D0/en
Priority claimed from PCT/US2001/002967 external-priority patent/WO2001057251A2/en
Priority claimed from GB0406170A external-priority patent/GB2396352B/en
Priority claimed from GB0406165A external-priority patent/GB2396351B/en
Priority claimed from GB0408566A external-priority patent/GB2397376B/en
Priority claimed from US09/864,761 external-priority patent/US20020048763A1/en
Priority claimed from AU6343201A external-priority patent/AU6343201A/en
Priority claimed from PCT/US2001/016981 external-priority patent/WO2001092524A2/en
Priority claimed from US09/866,108 external-priority patent/US6686188B2/en
Priority claimed from GB0227802A external-priority patent/GB2380197A/en
Priority claimed from US09/895,040 external-priority patent/US20020123474A1/en
Publication of GB2360284A publication Critical patent/GB2360284A/en
Priority claimed from PCT/US2001/029656 external-priority patent/WO2002024750A2/en
Priority claimed from AU9295701A external-priority patent/AU9295701A/en
Publication of GB2360284B publication Critical patent/GB2360284B/en
Application granted granted Critical
Application status is Expired - Fee Related legal-status Critical
Anticipated expiration legal-status Critical

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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809Methods for determination or identification of nucleic acids involving differential detection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/075Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/60Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/178Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
GB0024263A 2000-02-04 2000-10-04 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart Expired - Fee Related GB2360284B (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US18031200P true 2000-02-04 2000-02-04
US20745600P true 2000-05-26 2000-05-26
US23468700P true 2000-09-21 2000-09-21

Applications Claiming Priority (61)

Application Number Priority Date Filing Date Title
GB0115281A GB2361238B (en) 2000-02-04 2000-10-04 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart
PCT/US2001/002967 WO2001057251A2 (en) 2000-02-04 2001-01-29 Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
US09/774,203 US20020081590A1 (en) 2000-02-04 2001-01-29 Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
GB0123361A GB2373500B (en) 2000-02-04 2001-01-29 Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
PCT/US2001/003003 WO2001057252A2 (en) 2000-02-04 2001-01-29 Methods and apparatus for high-throughput detection and characterization of alternatively spliced genes
EP01905211A EP1290217A2 (en) 2000-02-04 2001-01-29 Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
AU3658901A AU3658901A (en) 2000-02-04 2001-01-29 Methods and apparatus for high-throughput detection and characterization of alternatively spliced genes
AU3087801A AU3087801A (en) 2000-02-04 2001-01-29 Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human breast and hbl 100 cells
AU3311401A AU3311401A (en) 2000-02-04 2001-01-29 Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
PCT/US2001/000669 WO2001057277A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human fetal liver
GB0406165A GB2396351B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human lung
AU3088001A AU3088001A (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human placenta
AU3088301A AU3088301A (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human hela cells or other human cervical epithelial cells
EP01904810A EP1309725A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human fetal liver
GB0217112A GB2375539B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human adult liver
GB0217835A GB2385053B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human breast and HBL 100 cells
PCT/US2001/000667 WO2001057275A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human brain
GB0217805A GB2378754B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human breast and BT 474 cells
PCT/US2001/000668 WO2001057276A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human bone marrow
AU3275701A AU3275701A (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human adult liver
GB0408566A GB2397376B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart
GB0217811A GB2382814B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human hela cells or other human cervical epithelial cells
PCT/US2001/000662 WO2001057271A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human breast and bt 474 cells
EP01903005A EP1325149A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart
AU3087901A AU3087901A (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human breast and bt 474 cells
PCT/US2001/000665 WO2001086003A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human lung
GB0217714A GB2374872A (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human bone marrow
AU3275901A AU3275901A (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human brain
GB0218673A GB2376237A (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human lung
PCT/US2001/000663 WO2001057272A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human placenta
GB0216928A GB2374929A (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart
GB0406170A GB2396352B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human bone marrow
PCT/US2001/000670 WO2001057278A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human hela cells or other human cervical epithelial cells
GB0217188A GB2375111B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human fetal liver
EP01904808A EP1332224A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human lung
AU3088201A AU3088201A (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human bone marrow
AU3276001A AU3276001A (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human fetal liver
AU3275801A AU3275801A (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human lung
EP01903002A EP1309723A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human breast and hbl 100 cells
PCT/US2001/000661 WO2001057270A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human breast and hbl 100 cells
AU3088101A AU3088101A (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human heart
EP01903006A EP1292705A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human bone marrow
EP01903004A EP1292704A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human placenta
EP01903003A EP1309724A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human breast and bt 474 cells
PCT/US2001/000666 WO2001057274A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart
EP01903007A EP1290216A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human hela cells or other human cervical epithelial cells
GB0217049A GB2383043B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human brain
GB0217861A GB2376018B (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human placenta
PCT/US2001/000664 WO2001057273A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human adult liver
EP01904807A EP1341930A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human adult liver
EP01904809A EP1325150A2 (en) 2000-02-04 2001-01-30 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human brain
US09/864,761 US20020048763A1 (en) 2000-02-04 2001-05-23 Human genome-derived single exon nucleic acid probes useful for gene expression analysis
AU6343201A AU6343201A (en) 2000-05-26 2001-05-23 Myosin-like gene expressed in human heart and muscle
JP2002500716A JP2004501617A (en) 2000-05-26 2001-05-25 Myosin-like genes expressed in human cardiac and muscle
GB0227802A GB2380197A (en) 2000-05-26 2001-05-25 Myosin-like gene expressed in human heart and muscle
PCT/US2001/016981 WO2001092524A2 (en) 2000-05-26 2001-05-25 Myosin-like gene expressed in human heart and muscle
US09/866,108 US6686188B2 (en) 2000-05-26 2001-05-25 Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle
US09/895,040 US20020123474A1 (en) 2000-10-04 2001-06-29 Human GTP-Rho binding protein2
PCT/US2001/029656 WO2002024750A2 (en) 2000-09-21 2001-09-21 Human kidney tumor overexpressed membrane protein 1
AU9295701A AU9295701A (en) 2000-09-21 2001-09-21 Human kidney tumor overexpressed membrane protein 1
US10/723,361 US20040137589A1 (en) 2000-05-26 2003-11-26 Human myosin-like polypeptide expressed predominantly in heart and muscle

Publications (3)

Publication Number Publication Date
GB0024263D0 GB0024263D0 (en) 2000-11-15
GB2360284A GB2360284A (en) 2001-09-19
GB2360284B true GB2360284B (en) 2002-02-27

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Application Number Title Priority Date Filing Date
GB0024263A Expired - Fee Related GB2360284B (en) 2000-02-04 2000-10-04 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030194704A1 (en) * 2002-04-03 2003-10-16 Penn Sharron Gaynor Human genome-derived single exon nucleic acid probes useful for gene expression analysis two

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1043405A2 (en) * 1999-04-05 2000-10-11 Affymetrix, Inc. Proportional amplification of nucleic acids
WO2001009369A2 (en) * 1999-07-30 2001-02-08 Affymetrix, Inc. Single-phase amplification of nucleic acids

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1043405A2 (en) * 1999-04-05 2000-10-11 Affymetrix, Inc. Proportional amplification of nucleic acids
WO2001009369A2 (en) * 1999-07-30 2001-02-08 Affymetrix, Inc. Single-phase amplification of nucleic acids

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GB0024263D0 (en) 2000-11-15
GB2360284A (en) 2001-09-19

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