GB2359083A - Mutant herpes simplex viruses and uses thereof - Google Patents

Mutant herpes simplex viruses and uses thereof

Info

Publication number
GB2359083A
GB2359083A GB0030820A GB0030820A GB2359083A GB 2359083 A GB2359083 A GB 2359083A GB 0030820 A GB0030820 A GB 0030820A GB 0030820 A GB0030820 A GB 0030820A GB 2359083 A GB2359083 A GB 2359083A
Authority
GB
United Kingdom
Prior art keywords
hsv
herpes simplex
simplex viruses
mutant herpes
mutant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB0030820A
Other versions
GB0030820D0 (en
GB2359083B (en
Inventor
Robert Stuart Coffin
David Seymour Latchman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biovex Ltd
Original Assignee
Biovex Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovex Ltd filed Critical Biovex Ltd
Publication of GB0030820D0 publication Critical patent/GB0030820D0/en
Publication of GB2359083A publication Critical patent/GB2359083A/en
Application granted granted Critical
Publication of GB2359083B publication Critical patent/GB2359083B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A herpes simplex virus (HSV) comprising: (i) an HSV LAT sequence inserted into an essential gene of the HSV; and (ii) a deletion in the endogenous LAT region of the HSV strain. The HSV of the invention can be used in the treatment of disorders of, or injuries to, the nervous system of a mammal.
GB0030820A 1998-05-20 1999-05-20 Mutant herpes simplex viruses and uses thereof Expired - Fee Related GB2359083B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9810904.4A GB9810904D0 (en) 1998-05-20 1998-05-20 Mutant herpes simplex viruses and uses thereof
PCT/GB1999/001598 WO1999060145A1 (en) 1998-05-20 1999-05-20 Mutant herpes simplex viruses and uses thereof

Publications (3)

Publication Number Publication Date
GB0030820D0 GB0030820D0 (en) 2001-01-31
GB2359083A true GB2359083A (en) 2001-08-15
GB2359083B GB2359083B (en) 2003-03-12

Family

ID=10832440

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB9810904.4A Ceased GB9810904D0 (en) 1998-05-20 1998-05-20 Mutant herpes simplex viruses and uses thereof
GB0030820A Expired - Fee Related GB2359083B (en) 1998-05-20 1999-05-20 Mutant herpes simplex viruses and uses thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GBGB9810904.4A Ceased GB9810904D0 (en) 1998-05-20 1998-05-20 Mutant herpes simplex viruses and uses thereof

Country Status (12)

Country Link
EP (1) EP1080215A1 (en)
JP (1) JP2002515256A (en)
KR (1) KR20010071292A (en)
CN (1) CN1192112C (en)
AU (1) AU756892B2 (en)
BR (1) BR9910594A (en)
CA (1) CA2328594A1 (en)
GB (2) GB9810904D0 (en)
HK (1) HK1036085A1 (en)
IL (1) IL139745A0 (en)
MX (1) MXPA00011346A (en)
WO (1) WO1999060145A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0009079D0 (en) * 2000-04-12 2000-05-31 Neurovex Ltd Herpes viruses for immune modulation
US6713067B2 (en) 1998-07-31 2004-03-30 Biovex Limited Herpes viruses for immune modulation
GB9930418D0 (en) * 1999-12-22 2000-02-16 Neurovex Ltd Replication incompetent herpes virus vectors
DE60107203T3 (en) 2000-01-21 2009-07-23 Biovex Ltd. HERPES VIRUSES FOR GENE THERAPY
US7063851B2 (en) 2000-04-12 2006-06-20 Biovex Limited Herpes viruses for immune modulation
CN101824409B (en) * 2003-04-25 2015-11-25 贝克顿·迪金森公司 1 type and herpes simplex types 2 virus is detected by nucleic acid amplification
GB0317511D0 (en) 2003-07-25 2003-08-27 Biovex Ltd Viral vectors
CN105637092B (en) * 2013-07-17 2021-06-11 匹兹堡大学-属高等教育联邦体系 Non-toxic HSV vectors for efficient gene delivery applications and complementing cells for their production
GB201505860D0 (en) 2015-04-07 2015-05-20 Agalimmune Ltd Therapeutic compositions and methods of use for treating cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996027672A1 (en) * 1995-03-08 1996-09-12 Glorioso Joseph C Latency active herpes virus promoters and their use to treat neurological lesions
WO1997013866A2 (en) * 1995-10-11 1997-04-17 University Of British Columbia Recombinant herpes virus vectors for expression in neuronal cells
WO1997020935A2 (en) * 1995-12-06 1997-06-12 Cambridge University Technical Services Limited Viral vectors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996027672A1 (en) * 1995-03-08 1996-09-12 Glorioso Joseph C Latency active herpes virus promoters and their use to treat neurological lesions
WO1997013866A2 (en) * 1995-10-11 1997-04-17 University Of British Columbia Recombinant herpes virus vectors for expression in neuronal cells
WO1997020935A2 (en) * 1995-12-06 1997-06-12 Cambridge University Technical Services Limited Viral vectors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Molecular Medicine Today Sept.(09) 1997. Lachmann R H et.al.pages 404-411 *
Nucl. Acid Res. Vol. 18 (12) 1990. Morgenstern J P & Land H pages 3587-3596 *

Also Published As

Publication number Publication date
MXPA00011346A (en) 2003-05-19
HK1036085A1 (en) 2001-12-21
CN1192112C (en) 2005-03-09
WO1999060145A1 (en) 1999-11-25
GB9810904D0 (en) 1998-07-22
BR9910594A (en) 2001-10-30
AU3946699A (en) 1999-12-06
IL139745A0 (en) 2002-02-10
KR20010071292A (en) 2001-07-28
EP1080215A1 (en) 2001-03-07
GB0030820D0 (en) 2001-01-31
AU756892B2 (en) 2003-01-23
CA2328594A1 (en) 1999-11-25
CN1310765A (en) 2001-08-29
GB2359083B (en) 2003-03-12
JP2002515256A (en) 2002-05-28

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20060520