BR9910594A - Herpes simplex virus, use of a herpessimplex virus, pharmaceutical composition and processes to study the function of a heterologous gene in a mammalian cell, to produce a herpes simplex virus and to treat a disorder or injury of a mammalian nervous system - Google Patents
Herpes simplex virus, use of a herpessimplex virus, pharmaceutical composition and processes to study the function of a heterologous gene in a mammalian cell, to produce a herpes simplex virus and to treat a disorder or injury of a mammalian nervous systemInfo
- Publication number
- BR9910594A BR9910594A BR9910594-2A BR9910594A BR9910594A BR 9910594 A BR9910594 A BR 9910594A BR 9910594 A BR9910594 A BR 9910594A BR 9910594 A BR9910594 A BR 9910594A
- Authority
- BR
- Brazil
- Prior art keywords
- virus
- herpes simplex
- simplex virus
- study
- mammalian
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
- C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"VìRUS DE HERPES SIMPLEX, USO DE UM VìRUS DEHERPES SIMPLEX, COMPOSIçãO FARMACêUTICA EPROCESSOS PARA ESTUDAR A FUNçãO DE UM GENEHETERóLOGO EM UMA CéLULA DE MAMìFERO, PARAPRODUZIR UM VìRUS DE HERPES SIMPLEX E PARA TRATARUM DISTúRBIO OU UMA LESãO DO SISTEMA NERVOSO DEUM MAMìFERO". Um virus de herpes simplex (HSV)compreendendo: (i) uma seq³ência de LAT de HSV inserida em umgene essencial do HSV; e (ii) uma deleção na região de LATendógena da cepa de HSV. O HSV da invenção pode ser usadono tratamento de distúrbios ou de lesões do sistema nervoso de ummamífero."SIMPLEX HERPES VIRUS, USE OF A SIMPLEX DEHERPES VIRUS, PHARMACEUTICAL COMPOSITION EPROCESSES TO STUDY THE FUNCTION OF A GENEHETEROLOGIST IN A MAMMALIAN CELL, PARAPRODUCING A MUSHROOM HERPERS VIRUS. A herpes simplex virus (HSV) comprising: (i) an HSV LAT sequence inserted into an essential HSV gene; and (ii) a deletion in the LATendogen region of the HSV strain. The HSV of the invention can be used in the treatment of disorders or injuries of the mammalian nervous system.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9810904.4A GB9810904D0 (en) | 1998-05-20 | 1998-05-20 | Mutant herpes simplex viruses and uses thereof |
PCT/GB1999/001598 WO1999060145A1 (en) | 1998-05-20 | 1999-05-20 | Mutant herpes simplex viruses and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9910594A true BR9910594A (en) | 2001-10-30 |
Family
ID=10832440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9910594-2A BR9910594A (en) | 1998-05-20 | 1999-05-20 | Herpes simplex virus, use of a herpessimplex virus, pharmaceutical composition and processes to study the function of a heterologous gene in a mammalian cell, to produce a herpes simplex virus and to treat a disorder or injury of a mammalian nervous system |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1080215A1 (en) |
JP (1) | JP2002515256A (en) |
KR (1) | KR20010071292A (en) |
CN (1) | CN1192112C (en) |
AU (1) | AU756892B2 (en) |
BR (1) | BR9910594A (en) |
CA (1) | CA2328594A1 (en) |
GB (2) | GB9810904D0 (en) |
HK (1) | HK1036085A1 (en) |
IL (1) | IL139745A0 (en) |
MX (1) | MXPA00011346A (en) |
WO (1) | WO1999060145A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0009079D0 (en) * | 2000-04-12 | 2000-05-31 | Neurovex Ltd | Herpes viruses for immune modulation |
US6713067B2 (en) | 1998-07-31 | 2004-03-30 | Biovex Limited | Herpes viruses for immune modulation |
GB9930418D0 (en) * | 1999-12-22 | 2000-02-16 | Neurovex Ltd | Replication incompetent herpes virus vectors |
US7223593B2 (en) | 2000-01-21 | 2007-05-29 | Biovex Limited | Herpes virus strains for gene therapy |
US7063851B2 (en) | 2000-04-12 | 2006-06-20 | Biovex Limited | Herpes viruses for immune modulation |
US7291488B2 (en) * | 2003-04-25 | 2007-11-06 | Becton, Dickinson & Company | Detection of herpes simplex virus types 1 and 2 by nucleic acid amplification |
GB0317511D0 (en) | 2003-07-25 | 2003-08-27 | Biovex Ltd | Viral vectors |
RU2714259C2 (en) * | 2013-07-17 | 2020-02-13 | Юниверсити Оф Питтсбург-Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн | Non-toxic vectors on hsv basis for applications in effective gene delivery and complementing cells for their production |
GB201505860D0 (en) | 2015-04-07 | 2015-05-20 | Agalimmune Ltd | Therapeutic compositions and methods of use for treating cancer |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5849571A (en) * | 1990-10-10 | 1998-12-15 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Latency active herpes virus promoters and their use |
US5763217A (en) * | 1993-11-10 | 1998-06-09 | University Of British Columbia | Method of using, process of preparing and composition comprising recombinant herpesvirus vectors |
GB9524973D0 (en) * | 1995-12-06 | 1996-02-07 | Lynxvale Ltd | Viral vectors |
-
1998
- 1998-05-20 GB GBGB9810904.4A patent/GB9810904D0/en not_active Ceased
-
1999
- 1999-05-20 AU AU39466/99A patent/AU756892B2/en not_active Ceased
- 1999-05-20 BR BR9910594-2A patent/BR9910594A/en not_active IP Right Cessation
- 1999-05-20 EP EP99922369A patent/EP1080215A1/en not_active Withdrawn
- 1999-05-20 IL IL13974599A patent/IL139745A0/en unknown
- 1999-05-20 WO PCT/GB1999/001598 patent/WO1999060145A1/en not_active Application Discontinuation
- 1999-05-20 MX MXPA00011346A patent/MXPA00011346A/en unknown
- 1999-05-20 CA CA002328594A patent/CA2328594A1/en not_active Abandoned
- 1999-05-20 GB GB0030820A patent/GB2359083B/en not_active Expired - Fee Related
- 1999-05-20 JP JP2000549751A patent/JP2002515256A/en active Pending
- 1999-05-20 KR KR1020007012952A patent/KR20010071292A/en not_active Application Discontinuation
- 1999-05-20 CN CNB998089281A patent/CN1192112C/en not_active Expired - Fee Related
-
2001
- 2001-09-26 HK HK01106782A patent/HK1036085A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO1999060145A1 (en) | 1999-11-25 |
CN1192112C (en) | 2005-03-09 |
GB0030820D0 (en) | 2001-01-31 |
IL139745A0 (en) | 2002-02-10 |
HK1036085A1 (en) | 2001-12-21 |
AU3946699A (en) | 1999-12-06 |
CA2328594A1 (en) | 1999-11-25 |
CN1310765A (en) | 2001-08-29 |
GB2359083A (en) | 2001-08-15 |
AU756892B2 (en) | 2003-01-23 |
KR20010071292A (en) | 2001-07-28 |
GB2359083B (en) | 2003-03-12 |
EP1080215A1 (en) | 2001-03-07 |
JP2002515256A (en) | 2002-05-28 |
GB9810904D0 (en) | 1998-07-22 |
MXPA00011346A (en) | 2003-05-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8O, 9O E 10O ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFENTE AO DESPACHO 8.6 DA RPI 2012 DE 28/07/2009. |