GB2284608A - 06-Methylguanine-DNA-methyltransferase (mgmt) specific antibodies - Google Patents

06-Methylguanine-DNA-methyltransferase (mgmt) specific antibodies

Info

Publication number
GB2284608A
GB2284608A GB9503702A GB9503702A GB2284608A GB 2284608 A GB2284608 A GB 2284608A GB 9503702 A GB9503702 A GB 9503702A GB 9503702 A GB9503702 A GB 9503702A GB 2284608 A GB2284608 A GB 2284608A
Authority
GB
United Kingdom
Prior art keywords
mgmt
hybridoma ecacc
methylguanine
methyltransferase
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9503702A
Other versions
GB9503702D0 (en
GB2284608B (en
Inventor
Benjamin Fuk Loi Li
Teck Choon Ayi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National University of Singapore
Original Assignee
National University of Singapore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929224888A external-priority patent/GB9224888D0/en
Application filed by National University of Singapore filed Critical National University of Singapore
Priority to GB9503702A priority Critical patent/GB2284608B/en
Publication of GB9503702D0 publication Critical patent/GB9503702D0/en
Publication of GB2284608A publication Critical patent/GB2284608A/en
Application granted granted Critical
Publication of GB2284608B publication Critical patent/GB2284608B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention provides antibodies capable of discriminating between native human MGMT and an active site alkylated form of this enzyme in an immunoprecipitation procedure. Monoclonal antibodies having such discriminating ability are obtainable from hybridoma ECACC 92112510 and hybridoma ECACC 93112514, which were deposited at the European Collection of Animal Cell Cultures, UK under the Budapest Treaty on 25th November 1992 and 25th November 1993 respectively. The monoclonal antibody of hybridoma ECACC 92112510 has been designated Mab 5H7. The monoclonal antibody of hybridoma ECACC 93112514 has been designated Mab 3C7.
GB9503702A 1992-11-27 1993-11-29 O6-methylguanine-DNA-methyltransferase (MGMT) specific antibodies Expired - Fee Related GB2284608B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9503702A GB2284608B (en) 1992-11-27 1993-11-29 O6-methylguanine-DNA-methyltransferase (MGMT) specific antibodies

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929224888A GB9224888D0 (en) 1992-11-27 1992-11-27 Monoclonal antibody
PCT/GB1993/002449 WO1994012660A1 (en) 1992-11-27 1993-11-29 06-methylguanine-dna-methyltransferase (mgmt) specific antibodies
GB9503702A GB2284608B (en) 1992-11-27 1993-11-29 O6-methylguanine-DNA-methyltransferase (MGMT) specific antibodies

Publications (3)

Publication Number Publication Date
GB9503702D0 GB9503702D0 (en) 1995-04-12
GB2284608A true GB2284608A (en) 1995-06-14
GB2284608B GB2284608B (en) 1996-08-21

Family

ID=26302056

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9503702A Expired - Fee Related GB2284608B (en) 1992-11-27 1993-11-29 O6-methylguanine-DNA-methyltransferase (MGMT) specific antibodies

Country Status (1)

Country Link
GB (1) GB2284608B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993024837A1 (en) * 1992-05-22 1993-12-09 Applied Genetics Inc. Assays for o6-methylguanine-dna methyltransferase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993024837A1 (en) * 1992-05-22 1993-12-09 Applied Genetics Inc. Assays for o6-methylguanine-dna methyltransferase

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Biosis Accession no. 90134717, & Biochemistry 29 (39). 1990.9234-9240. *
Cancer Research, Volume 50, January 1991, page 1897 - page 1903. *
Cancer Research, Volume 51, July 1991, page 3339 - page 3344 *
Cancer Research, Volume 52, December 1992, page 6423 - page 6430 *
Carcinogenesis, Volume 12, No 9, 1991, page 1739 - page 1744 *
NLM accession no. 89288527, & Carcinogenesis 1989 Jul;10(7):1203-8. *
The Journal of Biological Chemistry, Volume 266, No 2, January 1991, page 1064 - page 1070. *

Also Published As

Publication number Publication date
GB9503702D0 (en) 1995-04-12
GB2284608B (en) 1996-08-21

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Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20081129