GB2280110B - Pharmaceutically-active hydrophilic carotenoid antioxidants - Google Patents

Pharmaceutically-active hydrophilic carotenoid antioxidants

Info

Publication number
GB2280110B
GB2280110B GB9412938A GB9412938A GB2280110B GB 2280110 B GB2280110 B GB 2280110B GB 9412938 A GB9412938 A GB 9412938A GB 9412938 A GB9412938 A GB 9412938A GB 2280110 B GB2280110 B GB 2280110B
Authority
GB
United Kingdom
Prior art keywords
pharmaceutically
active hydrophilic
carotenoid antioxidants
carotenoid
antioxidants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9412938A
Other versions
GB2280110A (en
GB9412938D0 (en
Inventor
Alan Norman Howard
David I Thurnham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Howard Foundation
Original Assignee
Howard Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939313266A external-priority patent/GB9313266D0/en
Application filed by Howard Foundation filed Critical Howard Foundation
Publication of GB9412938D0 publication Critical patent/GB9412938D0/en
Publication of GB2280110A publication Critical patent/GB2280110A/en
Application granted granted Critical
Publication of GB2280110B publication Critical patent/GB2280110B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GB9412938A 1993-06-28 1994-06-28 Pharmaceutically-active hydrophilic carotenoid antioxidants Expired - Fee Related GB2280110B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939313266A GB9313266D0 (en) 1993-06-28 1993-06-28 Antioxidants for lipoproteins
US21989794A 1994-03-30 1994-03-30

Publications (3)

Publication Number Publication Date
GB9412938D0 GB9412938D0 (en) 1994-08-17
GB2280110A GB2280110A (en) 1995-01-25
GB2280110B true GB2280110B (en) 1997-11-12

Family

ID=26303133

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9412938A Expired - Fee Related GB2280110B (en) 1993-06-28 1994-06-28 Pharmaceutically-active hydrophilic carotenoid antioxidants

Country Status (4)

Country Link
AU (1) AU7005694A (en)
GB (1) GB2280110B (en)
IL (1) IL110139A0 (en)
WO (1) WO1995000130A1 (en)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
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US6329432B2 (en) 1993-06-28 2001-12-11 The Howard Foundation Mesozeaxanthin formulations for treatment of retinal disorders
GB2289406A (en) * 1994-04-15 1995-11-22 Britannia Health Products Ltd Vitamin, betacarotene and zinc composition for sperm health
US5527533A (en) * 1994-10-27 1996-06-18 Board Of Trustees Of The University Of Illinois Method of retarding and ameliorating central nervous system and eye damage
AU705467C (en) * 1994-12-22 2002-12-19 Cognis Corporation Pharmaceutical compositions comprising lycopene
US6262109B1 (en) 1995-12-22 2001-07-17 Henkel Corporation Methods of preventing and/or treating high serum levels of cholesterol and/or lipids
ES2283002T3 (en) * 1995-06-07 2007-10-16 The Howard Foundation PHARMACEUTICALLY ACTIVE CAROTENOIDS.
JP2750281B2 (en) * 1995-06-15 1998-05-13 睦憲 藤原 Hypercholesterolemia treatment
JPH09124470A (en) 1995-10-26 1997-05-13 Suntory Ltd Antistress composition
US6140309A (en) * 1996-03-12 2000-10-31 University Of South Florida Vasoactive effects and free radical generation by β-amyloid peptides
WO1997048388A1 (en) * 1996-06-17 1997-12-24 The Board Of Trustees Of The University Of Illinois Method of retarding and ameliorating central nervous system and eye damage
IT1283143B1 (en) * 1996-07-12 1998-04-07 Indena Spa METHOD OF EXTRACTION OF THE LYCOPENE AND EXTRACTS THAT CONTAIN IT
EP0966960A1 (en) * 1996-11-27 1999-12-29 Dainippon Ink And Chemicals, Inc. Agent for inhibiting carcinogenesis or tumor metastasis
JP2001511153A (en) * 1997-02-04 2001-08-07 ブイ． コスバブ，ジョン Compositions and methods for prevention and treatment of vascular degenerative diseases
SE522246C2 (en) 1997-02-27 2004-01-27 Astacarotene Ab Oral preparation for prophylactic and therapeutic treatment of Helicobacter Sp. infection
AU752468B2 (en) * 1997-04-04 2002-09-19 Phyllis E. Bowen Lutein esters having high bioavailability
SE512531C2 (en) * 1997-09-04 2000-03-27 Astacarotene Ab Use of at least one type of xanthophyll for the manufacture of a medicament for the prophylactic and / or therapeutic improvement of mammalian muscle function and / or treatment of mammalian muscle disorders or disorders
SE524337C2 (en) * 1998-10-16 2004-07-27 Astacarotene Ab Use of at least one type of xanthophyll for the manufacture of a medicament for the prophylactic and / or therapeutic treatment of indigestion
NL1010351C2 (en) * 1998-10-19 2001-01-08 Werklust & Beheer B V Carotenoid esters for use in the prevention and treatment of eye diseases.
IL129442A0 (en) * 1999-04-14 2000-02-29 Lycored Natural Prod Ind Ltd Compounds useful in reducing the level of insulin like growth factor-1 (IGF-1) in blood
ES2283318T3 (en) * 1999-10-04 2007-11-01 John Carter PHARMACEUTICAL COMPOSITIONS CONTAINING COPPER, SALICILIC ACID AND VITAMIN C.
HU227182B1 (en) * 2000-03-06 2010-09-28 Andras Javor Lecitin-ascorbic acid combination
AU2001283528A1 (en) * 2000-07-31 2002-02-13 Neuronautics, Inc. Improved methods for identifying reagents which inhibit tau polymerization
GB2374008B (en) * 2001-04-04 2005-03-16 John Carter Pharmaceutical compositions comprising copper and zinc
GB0119052D0 (en) * 2001-08-03 2001-09-26 Mars Uk Ltd Foodstuff
GB0202900D0 (en) 2002-02-07 2002-03-27 Laxdale Ltd Novel formulations of drugs
US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
JP2005518453A (en) 2002-02-25 2005-06-23 ディフュージョン・ファーマシューティカルズ・エルエルシー Bipolar trans carotenoid salts and their use
EP1667954B1 (en) * 2003-08-25 2018-11-14 Diffusion Pharmaceuticals LLC Bipolar trans carotenoid salts and their uses
US7351424B2 (en) 2004-07-22 2008-04-01 Bio Lut S.A. De C.V. Enhanced purity trans-lutein-ester compositions and methods of making same
EP2540696B1 (en) 2005-02-24 2020-01-01 Diffusion Pharmaceuticals LLC Trans carotenoids, formulation and uses
JP5099812B2 (en) * 2006-04-07 2012-12-19 株式会社カネカ Blood sugar level rise inhibitor
JPWO2007116980A1 (en) * 2006-04-07 2009-08-20 国立大学法人 北海道大学 Blood sugar level rise inhibitor
US20070293568A1 (en) 2006-06-16 2007-12-20 Yamaha Hatsudoki Kabushiki Kaisha Neurocyte Protective Agent
JP5223083B2 (en) * 2006-06-21 2013-06-26 国立大学法人京都大学 Angiogenesis inhibitor
EP3483140A1 (en) 2007-04-13 2019-05-15 Diffusion Pharmaceuticals LLC Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease
CA2703946A1 (en) 2007-10-31 2009-05-07 Diffusion Pharmaceuticals Llc A new class of therapeutics that enhance small molecule diffusion
KR101875843B1 (en) 2009-06-22 2018-07-06 디퓨젼 파마슈티컬즈 엘엘씨 Diffusion enhancing compounds and their use alone or with thrombolytics
TWI492744B (en) 2009-12-04 2015-07-21 Abbott Lab Methods of modulating inflammation in preterm infants using carotenoids
AU2011262361A1 (en) 2010-06-02 2013-01-10 Diffusion Pharmaceuticals Llc Oral formulations of bipolar trans carotenoids
US20130189382A1 (en) * 2010-09-30 2013-07-25 Beijing Gingko Group Biological Technology Co., Ltd. Use of fucoxanthin in the preparation of product for improving memory and having neuroprotective effect associated with neurodegenerative disorder
CN105120853A (en) * 2013-03-28 2015-12-02 奥米尼埃克蒂夫健康科技有限公司 Neuroprotective effect of carotenoids in brain
US11185523B2 (en) 2016-03-24 2021-11-30 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer
GB201618350D0 (en) * 2016-10-31 2016-12-14 Ip Science Ltd Methods and compositions comprising carotenoids

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1323800A (en) * 1970-07-10 1973-07-18 Hoffmann La Roche Light-screening agents
DE2923032A1 (en) * 1979-06-07 1980-12-11 Waldemar Hankin Pharmaceutical compsn. contg. heron egg yolk - for restoring balance between iron and gold in the blood
WO1985003225A1 (en) * 1984-01-25 1985-08-01 L'oreal Medicinal composition for the treatment or prevention of acne by topical application
JPH0249091A (en) * 1988-08-11 1990-02-19 Suntory Ltd Astaxanthin-containing composition
US4929774A (en) * 1988-01-29 1990-05-29 Basf Aktiengesellschaft Stable mixture containing oxidation-sensitive compounds, preparation thereof and use of a combination of substances for stabilizing oxidation-sensitive compounds
EP0385335A2 (en) * 1989-02-28 1990-09-05 Nisshin Flour Milling Co., Ltd. Stabilized fat-soluble vitamin compositions
US4957681A (en) * 1988-04-15 1990-09-18 Basf Aktiengesellschaft Preparation of pharmaceutical mixtures
DE4020874A1 (en) * 1989-06-29 1991-01-24 Niva Dr Shapira Soft drink giving protection against sun-light exposure - contains carotenoid and Vitamin=C or Vitamin=E
WO1991006292A1 (en) * 1989-11-02 1991-05-16 Danochemo A/S Process of preparing a water dispersible hydrophobic or aerophilic solid
WO1992005780A1 (en) * 1990-10-01 1992-04-16 Brigham And Women's Hospital Beta-carotene and vitamin e therapy for inhibition of major vascular events
DE4141351A1 (en) * 1991-12-14 1993-06-17 Basf Ag STABLE POWDERFUL VITAMIN AND / OR CAROTINOIDE PREPARATES AND PROCESS FOR THEIR PREPARATION

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1323800A (en) * 1970-07-10 1973-07-18 Hoffmann La Roche Light-screening agents
DE2923032A1 (en) * 1979-06-07 1980-12-11 Waldemar Hankin Pharmaceutical compsn. contg. heron egg yolk - for restoring balance between iron and gold in the blood
WO1985003225A1 (en) * 1984-01-25 1985-08-01 L'oreal Medicinal composition for the treatment or prevention of acne by topical application
US4929774A (en) * 1988-01-29 1990-05-29 Basf Aktiengesellschaft Stable mixture containing oxidation-sensitive compounds, preparation thereof and use of a combination of substances for stabilizing oxidation-sensitive compounds
US4957681A (en) * 1988-04-15 1990-09-18 Basf Aktiengesellschaft Preparation of pharmaceutical mixtures
JPH0249091A (en) * 1988-08-11 1990-02-19 Suntory Ltd Astaxanthin-containing composition
EP0385335A2 (en) * 1989-02-28 1990-09-05 Nisshin Flour Milling Co., Ltd. Stabilized fat-soluble vitamin compositions
DE4020874A1 (en) * 1989-06-29 1991-01-24 Niva Dr Shapira Soft drink giving protection against sun-light exposure - contains carotenoid and Vitamin=C or Vitamin=E
WO1991006292A1 (en) * 1989-11-02 1991-05-16 Danochemo A/S Process of preparing a water dispersible hydrophobic or aerophilic solid
WO1992005780A1 (en) * 1990-10-01 1992-04-16 Brigham And Women's Hospital Beta-carotene and vitamin e therapy for inhibition of major vascular events
DE4141351A1 (en) * 1991-12-14 1993-06-17 Basf Ag STABLE POWDERFUL VITAMIN AND / OR CAROTINOIDE PREPARATES AND PROCESS FOR THEIR PREPARATION

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Annals New York Academy of Sciences, Vol. 69, 1992, pp 7-20 *
Chemical Abstracts 107: 161484 & Acta Pharm. Hung. 57(3-4), pages 153-8 (1987) *
Chemical Abstracts 109:215833 & Khim. Prir.Soedin, 4, pages 524-9 (1988) *
Chemical Abstracts 113:65273 & JP 02 049 091 A *
Chemical Abstracts 119:56200 & DE 4141351 A *
WPI Abstract Accession No.1980-90343C & DE 2923032 A *

Also Published As

Publication number Publication date
WO1995000130A1 (en) 1995-01-05
IL110139A0 (en) 1994-10-07
GB2280110A (en) 1995-01-25
AU7005694A (en) 1995-01-17
GB9412938D0 (en) 1994-08-17

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20010628