GB2225942A - Topical veterinary treatment containing calcium soap - Google Patents

Topical veterinary treatment containing calcium soap Download PDF

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Publication number
GB2225942A
GB2225942A GB8928185A GB8928185A GB2225942A GB 2225942 A GB2225942 A GB 2225942A GB 8928185 A GB8928185 A GB 8928185A GB 8928185 A GB8928185 A GB 8928185A GB 2225942 A GB2225942 A GB 2225942A
Authority
GB
United Kingdom
Prior art keywords
calcium soap
grease
treatment
use according
calcium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB8928185A
Other versions
GB8928185D0 (en
GB2225942B (en
Inventor
May Edwina Julianne Le
May David Swinburne Le
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888829025A external-priority patent/GB8829025D0/en
Application filed by Individual filed Critical Individual
Publication of GB8928185D0 publication Critical patent/GB8928185D0/en
Publication of GB2225942A publication Critical patent/GB2225942A/en
Application granted granted Critical
Publication of GB2225942B publication Critical patent/GB2225942B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Detergent Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)

Abstract

A topical medicament containing a calcium soap is used to prevent or treat inflammatory skin disease in horses and ponies. The soap may be calcium stearate or 12-hydroxy stearate. The medicament preferably includes a paraffinic mineral oil to form a grease. Skin diseases mentioned are sweet-itch, mud fever and rain scald.

Description

VETERINARY TREATMENT This invention is concerned with a novel medicament for veterinary use, particularly in the treatment or prophylaxis of sweet-itch in horses and ponies.
Sweet-itch is a seasonal allergic inflammation of the skin of horses and ponies caused by a hypersensitive reaction. Insect bites, particularly from culicoides midges, are suspected of causing or exacerbating the condition. Hitherto treatment has been by application of soothing materials, such as calamine and anti-histamine creams, and anti-parasite preparations such as benzyl benzoate. Anti-inflammatory drugs such as corticosteroids have also been used, but prolonged use of such strong remedies is undesirable. The effect of topical application of water/oil emulsions is generally of short duration. As a preventive treatment, fly repellents have generally been too short-acting.
Similar inflammatory reactions can be caused by contact with mud and rain, giving rise to mud fever and rain scald.
The present invention is based on the discovery that calcium soap grease not only has a soothing effect on existing problems, but inhibits further outbreaks, and when applied early enough can prevent the onset of the condition.
In one )aspect the present invention provides calcium soap grease for the treatment or prophylaxis of inflammatory skin reactions in horses and ponies.
In another aspect the present invention provides the use of . calcium soap grease for the manufacture of a medicament for the treatment or prophylaxis of inflammatory skin reactions in horses and ponies.
The calcium soap grease medicament has been found particularly useful in respect of sweet-itch problems, but it may also be used in cases of mud fever and rain scald.
The calcium soap grease preferably comprises a mineral oil thickened with a calcium soap. The calcium soap is preferably calcium stearate, particularly calcium 12-hydroxy stearate.
The mineral oil is preferably a paraffinic oil which has been solvent refined and with a low aromatic hydrocarbon content, preferably less that 4%. A mineral oil having an initial boiling point of about 210-C and a final boiling point of about 495-500"C is especially suitable.
To prepare the grease, the calcium soap is blended with the mineral oil and the mixture is heated, for example at a temperature of about 130*C, with constant mixing until a desired penetration value of the cooled product is reached.
A product with a penetration value of 265-295 at 25 C is particularly suitable (Cone Penetration - ASTM D 217/82).
The calcium soap is used in an amount which will provide a desired thickening effect to the mineral oil. An amount of about 15% by weight of the combined soap/oil mixture has been found to give a suitable product.
Alternatively the calcium soap grease may comprise a blend of calcium stearate and a mineral oil or grease.
The calcium soap grease is preferably used directly as the medicament, without the addition of additives. However conventional veterinarially acceptable additives may be incorporated provided that they do not effect the efficacy of the product. For example dyestuffs, colouring agents, or additional thickeners or viscosity modifiers may be used to adjust the appearance or feel of the product. The pure product is preferred.
In ponies and horses known to suffer from sweet-itch, the calcium soap grease is typically applied to the potential sites of irritation, usually around the mane and tail, at the beginning of the midge season usually at weekly intervals.
Further applications are made if signs of sweet-itch are noticed. When animals are already suffering more frequent application may be necessary around the sites of irritation and to soften and remove any crusts that have formed.
The medicament may also be similarly used for prevention or treatment of mud fever or rain scald by applying the medicament to an inflamed area or an area of skin likely to be affected by the problem. In the case of mud fever this will primarily be the legs and possibly the stomach of the horse or pony. In the case of rain scald the upper body portions, primarily the back, will be the area to be treated.
In the absence of an inflammatory problem the medicament may be used in similar fashion as an insect-repellent, especially a fly-repellent.
In an alternative embodiment of the invention the medicament comprises a calcium soap alone or blended with veterinarially acceptable emollients.

Claims (12)

1. The use of a calcium soap for the manufacture of a medicament for the treatment or prophylaxis of inflammatory skin reactions in horses and ponies.
2. The use of a calcium soap grease for the manufacture of a medicament for the treatment or prophylaxis of inflammatory skin reactions in horses and ponies.
3. The use according to Claim 2 in which the calcium soap grease is a mineral oil thickened by heating with a calcium soap.
4. The use according to Claim 3, in which the mineral oil is an oil having an initial boiling point of about 210*C and a final boiling point of about 495-500'C.
5. The use according to Claim 2 in which the calcium soap grease is a blend of a calcium soap and a mineral oil or grease.
6. The use according to any one of Claims 2 to 5, in which the calcium soap comprises about 15% of the grease.
7. The use according to any one of Claims 1 to 6 in which the calcium soap is calcium stearate.
8. The use according to any one of Claims 1 to 7, in which the medicament is for the treatment of sweet-itch.
9. The use according to any one of Claims 1 to 7, in which the medicament is for the treatment of mud fever or rain scald.
10. A veterinary composition comprising a calcium soap dispersed in a veterinarially acceptable carrier.
11. A calcium soap as a therapeutic agent for the treatment or prophylaxis of inflammatory skin reactions in horses and ponies.
12. A calcium soap grease as a therapeutic agent for the treatment or prophylaxis of inflammatory skin reactions in horses and ponies.
GB8928185A 1988-12-13 1989-12-13 Calcium soap for the treatment of inflammatory skin conditions Expired - Lifetime GB2225942B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888829025A GB8829025D0 (en) 1988-12-13 1988-12-13 Veterinary composition
GB898902908A GB8902908D0 (en) 1988-12-13 1989-02-09 Non-veterinary composition(c)

Publications (3)

Publication Number Publication Date
GB8928185D0 GB8928185D0 (en) 1990-02-14
GB2225942A true GB2225942A (en) 1990-06-20
GB2225942B GB2225942B (en) 1992-04-15

Family

ID=26294718

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8928185A Expired - Lifetime GB2225942B (en) 1988-12-13 1989-12-13 Calcium soap for the treatment of inflammatory skin conditions

Country Status (1)

Country Link
GB (1) GB2225942B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002036130A1 (en) * 2000-11-03 2002-05-10 H-10 Limited Veterinary composition for the topical treatment of traumatized or inflamed skin
GB2409159A (en) * 2003-12-15 2005-06-22 Donald Henry Yates A preparation for treating mud fever in horses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB844683A (en) * 1955-07-14 1960-08-17 Edmond Hustinx Process for the manufacture of water-insoluble salts of polyvalent metals

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6056122B2 (en) * 1980-05-21 1985-12-09 塩野義製薬株式会社 sustained release formulation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB844683A (en) * 1955-07-14 1960-08-17 Edmond Hustinx Process for the manufacture of water-insoluble salts of polyvalent metals

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002036130A1 (en) * 2000-11-03 2002-05-10 H-10 Limited Veterinary composition for the topical treatment of traumatized or inflamed skin
GB2388028A (en) * 2000-11-03 2003-11-05 H 10 Ltd Veterinary composition for the topical treatment of traumatized or inflamed skin
GB2409159A (en) * 2003-12-15 2005-06-22 Donald Henry Yates A preparation for treating mud fever in horses
GB2409159B (en) * 2003-12-15 2008-02-20 Donald Henry Yates A preparation for use in the treatment of mud fever in horses

Also Published As

Publication number Publication date
GB8928185D0 (en) 1990-02-14
GB2225942B (en) 1992-04-15

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Expiry date: 20091212